BB-norm+ner@ldeleger:BB-norm+ner-16263187 / 136-1930 JSONTXT

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bionlp-ost-19-BB-norm-ner-train

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T2 0-1794 Paragraph denotes The ability of Lactobacillus (Lb.) gasseri K 7 to inhibit adhesion of Escherichia coli O8:K88 to intestinal mucosa was studied on cultured Caco-2 cells and ex vivo on pigs' small intestinal tissue. Lactobacilli were added simultaneously with E. coli, before E. coli and after E. coli for competition, exclusion and displacement assays. The concentration of lactobacilli on fully differentiated Caco-2 cells was 4.5+/-0.3 x 10(8) cfu/well, while the concentration of E. coli varied from 1.5 x 10(6) to 4.3 x 10(8) cfu/well. The number of E. coli adhered to Caco-2 monolayer (cfu/well) was lineary correlated (R(2)=0.97) to the concentration of added cells. In the assay simulating exclusion, E. coli adhesion was reduced by Lb. gasseri K 7 strain by 0.1 to 0.6 log cfu/well. The binding of E. coli was inhibited even more when incubated simultaneously with lactobacilli, particularly at the lowest concentration of E. coli (ratio E. coli/lactobacilli 1:248), where five-times reduction (or 0.7 log) was observed. When adhesion to tissue derived from pigs' jejunum was tested, concentration of E. coli was constant (6.9+/-0.14 x 10(7) cfu/ml), while the concentration of Lb. gasseri K 7 was 5.9 x 10(7) and 1.3 x 10(7) cfu/ml in two independent experiments, respectively. The adhesion of E. coli and Lb. gasseri K 7 cells to jejunal mucosa was similar (1.0+/-0.17 x 10(6) and 1.54+/-0.10 x 10(6) cfu/cm(2)) when the concentrations of single strains in suspensions were approximately the same. No significant competition, exclusion or displacement of E. coli by lactobacilli was observed on jejunal tissue. In conclusion, Lb. gasseri K 7 was found to be effective in reducing E. coli adhesion to Caco-2 enterocytes, but it was not able to do so in ex vivo conditions tested for pig jejunal tissue.
T10 15-46 Microorganism denotes Lactobacillus (Lb.) gasseri K 7 1334627
T11 58-66 Phenotype denotes adhesion OBT:000029
T12 70-93 Microorganism denotes Escherichia coli O8:K88 1010796
T13 97-114 Habitat denotes intestinal mucosa OBT:002993
T14 97-107 Habitat denotes intestinal OBT:002810
T15 130-151 Habitat denotes cultured Caco-2 cells OBT:000268|OBT:000062
T16 167-196 Habitat denotes pigs' small intestinal tissue OBT:002993
T17 167-171 Habitat denotes pigs OBT:003337
T18 173-189 Habitat denotes small intestinal OBT:003303
T19 198-210 Microorganism denotes Lactobacilli 1334627
T20 242-249 Microorganism denotes E. coli 1010796
T21 258-265 Microorganism denotes E. coli 1010796
T22 276-283 Microorganism denotes E. coli 1010796
T23 357-369 Microorganism denotes lactobacilli 1334627
T24 373-406 Habitat denotes fully differentiated Caco-2 cells OBT:000061
T25 466-473 Microorganism denotes E. coli 1010796
T26 537-544 Microorganism denotes E. coli 1010796
T27 556-562 Habitat denotes Caco-2 OBT:000061
T28 691-698 Microorganism denotes E. coli 1010796
T29 699-707 Phenotype denotes adhesion OBT:000029
T30 723-738 Microorganism denotes Lb. gasseri K 7 1334627
T31 778-785 Phenotype denotes binding OBT:000029
T32 789-796 Microorganism denotes E. coli 1010796
T33 856-868 Microorganism denotes lactobacilli 1334627
T34 914-921 Microorganism denotes E. coli 1010796
T35 929-936 Microorganism denotes E. coli 1010796
T36 937-949 Microorganism denotes lactobacilli 1334627
T37 1017-1025 Phenotype denotes adhesion OBT:000029
T38 1029-1062 Habitat denotes tissue derived from pigs' jejunum OBT:002993
T39 1049-1062 Habitat denotes pigs' jejunum OBT:001605
T40 1049-1053 Habitat denotes pigs OBT:003337
T41 1092-1099 Microorganism denotes E. coli 1010796
T42 1169-1184 Microorganism denotes Lb. gasseri K 7 1334627
T43 1274-1282 Phenotype denotes adhesion OBT:000029
T44 1286-1293 Microorganism denotes E. coli 1010796
T45 1298-1313 Microorganism denotes Lb. gasseri K 7 1334627
T47 1323-1337 Habitat denotes jejunal mucosa OBT:002993
T46 1323-1330 Habitat denotes jejunal OBT:001605
T48 1548-1555 Microorganism denotes E. coli 1010796
T49 1559-1571 Microorganism denotes lactobacilli 1334627
T51 1588-1602 Habitat denotes jejunal tissue OBT:002993
T50 1588-1595 Habitat denotes jejunal OBT:001605
T52 1619-1634 Microorganism denotes Lb. gasseri K 7 1334627
T53 1673-1680 Microorganism denotes E. coli 1010796
T54 1681-1689 Phenotype denotes adhesion OBT:000029
T55 1693-1711 Habitat denotes Caco-2 enterocytes OBT:000268
T56 1775-1793 Habitat denotes pig jejunal tissue OBT:000196|OBT:002993
T57 1775-1778 Habitat denotes pig OBT:003337
T58 1779-1786 Habitat denotes jejunal OBT:001605