BB-norm+ner@ldeleger:BB-norm+ner-10496597 JSONTXT

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bionlp-ost-19-BB-norm-ner-dev

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T1 0-137 Title denotes The differential diagnosis of early gastric mucosa-associated lymphoma: polymerase chain reaction and paraffin section immunophenotyping.
T2 138-2048 Paragraph denotes The distinction between benign florid lymphoid hyperplasia and low-grade gastric mucosal-associated lymphoid tissue (MALT) lymphoma may be a challenge. The presence of monoclonal B cells in Helicobacter pylori-chronic active gastritis has suggested that polymerase chain reaction (PCR) data should be viewed with caution. We investigated the reliability of PCR versus immunophenotyping in diagnosing early gastric MALT lymphoma. We studied 1511 biopsies from eight patients with high-grade primary gastric lymphoma, 25 with low-grade MALT lymphoma, 32 with atypical lymphoid infiltrates, and 39 with Helicobacter pylori-chronic active gastritis. Paraffin sections from all cases were stained with antibodies to CD20, CD3, AE1/AE3, kappa and lambda. PCR was performed on paraffin sections using the primer set VH-FR3/J(H). Using histopathology as the gold standard in diagnosis, we confirmed monoclonality in 22 of 25 MALT lymphomas (88%); a clonal band was found in 38% (15 of 39) of patients with chronic active gastritis. An immunophenotype pattern with predominance of CD20-positive cells in lymphocytic infiltrates was associated with monoclonality in 92% of cases. The presence of an enlarged irregular mantle zone was found in both monoclonal and polyclonal areas. An equal prevalence of B and T cells in lymphocytic infiltrates was associated with a polyclonal pattern in 24 of 31 cases (77%). Immunostaining of sIg (kappa and lambda) was difficult in paraffin sections and convincing proof of monoclonality was not obtained. Lymphoepithelial lesions were infrequent in gastric biopsies and their presence was highlighted with keratin stains. Because monoclonal B cells are observed in Helicobacter pylori-associated gastritis, the correct interpretation of clonality by PCR remains unclear. Paraffin section IHC using CD20 and CD3 is especially useful to confirm the diagnosis of gastric MALT lymphoma.
T4 36-50 Habitat denotes gastric mucosa OBT:001577
T3 36-43 Habitat denotes gastric OBT:001792
T5 211-253 Habitat denotes gastric mucosal-associated lymphoid tissue OBT:000334
T6 211-226 Habitat denotes gastric mucosal OBT:001577
T7 211-218 Habitat denotes gastric OBT:001792
T8 255-259 Habitat denotes MALT OBT:000334
T9 306-324 Habitat denotes monoclonal B cells OBT:001623
T10 328-347 Microorganism denotes Helicobacter pylori 210
T12 544-556 Habitat denotes gastric MALT OBT:000334
T11 544-551 Habitat denotes gastric OBT:001792
T16 603-652 Habitat denotes patients with high-grade primary gastric lymphoma OBT:003220
T14-1 603-611,657-685 Habitat denotes patients with low-grade MALT lymphoma
T13-1 603-611,690-724 Habitat denotes patients with atypical lymphoid infiltrates
T15-1 603-611,733-782 Habitat denotes patients with Helicobacter pylori-chronic active gastritis
T17 636-643 Habitat denotes gastric OBT:001792
T18 672-676 Habitat denotes MALT OBT:000334
T19 738-757 Microorganism denotes Helicobacter pylori 210
T20 849-853 Habitat denotes CD20 OBT:001623
T21 855-858 Habitat denotes CD3 OBT:001623
T22 1055-1059 Habitat denotes MALT OBT:000334
T23 1122-1160 Habitat denotes patients with chronic active gastritis OBT:003220
T24 1210-1229 Habitat denotes CD20-positive cells OBT:001623
T25 1233-1244 Habitat denotes lymphocytic OBT:001623
T26-1 1432-1433,1440-1445 Habitat denotes B cells
T27 1438-1445 Habitat denotes T cells OBT:001623
T28 1449-1460 Habitat denotes lymphocytic OBT:001623
T30 1671-1695 Habitat denotes Lymphoepithelial lesions OBT:000332
T29 1671-1687 Habitat denotes Lymphoepithelial OBT:000334|OBT:001091
T32 1715-1731 Habitat denotes gastric biopsies OBT:000110
T31 1715-1722 Habitat denotes gastric OBT:001792
T33 1796-1814 Habitat denotes monoclonal B cells OBT:001623
T34 1831-1850 Microorganism denotes Helicobacter pylori 210
T35 1964-1968 Habitat denotes CD20 OBT:001623
T36 1973-1976 Habitat denotes CD3 OBT:001623
T37 2026-2038 Habitat denotes gastric MALT OBT:000334
T38 2026-2033 Habitat denotes gastric OBT:001792