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bionlp-ost-19-BB-kb-test

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Id Subject Object Predicate Lexical cue
T1 0-146 Title denotes Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells.
T3 0-12 Phenotype denotes Pathogenesis
T4 38-51 Phenotype denotes Gram-negative
T6 111-145 Habitat denotes liver sinusoidal endothelial cells
T5 111-116 Habitat denotes liver
T7 128-139 Habitat denotes endothelial
T2 147-1551 Paragraph denotes The Gram-negative bacterium Pseudomonas aeruginosa is one of the most common opportunistic pathogens, especially after liver transplantation. Pathophysiological alterations of liver sinusoidal endothelial cells (LSECs) have far-reaching repercussions on the liver and on metabolism. LSECs are perforated with fenestrations, pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Gram-negative bacterial endotoxin (lipopolysaccharide, LPS) and the P. aeruginosa toxin, pyocyanin, have marked effects on LSECs. Initial loss of LSEC porosity (defenestration) induced by P. aeruginosa pyocyanin and LPS may confer subsequent immune tolerance to circulating bacterial antigens and toxins. This review collates the known immune responses of the liver to Gram-negative bacterial toxins, with a focus on LSECs. Hyperlipidemia is an important response to Gram-negative bacterial sepsis. The mechanisms proposed for sepsis-associated hyperlipidemia include tissue lipoprotein lipase inhibition and upregulated hepatic triglyceride production. In this review, we propose defenestration of the LSECs by bacterial toxins as an additional mechanism for the hyperlipidemia of sepsis. Given the role of LSECs in hyperlipidemia and liver allograft rejection, LSEC changes induced by P. aeruginosa toxins including LPS and pyocyanin may have significant clinical implications.
T8 151-164 Phenotype denotes Gram-negative
T9 175-197 Microorganism denotes Pseudomonas aeruginosa
T10 217-247 Phenotype denotes common opportunistic pathogens
T11 266-271 Habitat denotes liver
T12 323-357 Habitat denotes liver sinusoidal endothelial cells
T13 323-328 Habitat denotes liver
T14 340-351 Habitat denotes endothelial
T15 359-364 Habitat denotes LSECs
T16 405-410 Habitat denotes liver
T17 430-435 Habitat denotes LSECs
T18 549-554 Habitat denotes blood
T19 559-570 Habitat denotes hepatocytes
T20 572-585 Phenotype denotes Gram-negative
T21 640-653 Microorganism denotes P. aeruginosa
T22 695-700 Habitat denotes LSECs
T23 718-722 Habitat denotes LSEC
T24 760-773 Microorganism denotes P. aeruginosa
T25 932-937 Habitat denotes liver
T26 941-954 Phenotype denotes Gram-negative
T27 989-994 Habitat denotes LSECs
T28 1039-1052 Phenotype denotes Gram-negative
T29 1275-1280 Habitat denotes LSECs
T30 1380-1385 Habitat denotes LSECs
T31 1408-1413 Habitat denotes liver
T32 1435-1439 Habitat denotes LSEC
T33 1459-1472 Microorganism denotes P. aeruginosa