BB-kb+ner@ldeleger:BB-kb+ner-21917915 JSONTXT

{"project":"bionlp-ost-19-BB-kb-ner-train","denotations":[{"id":"T1","span":{"begin":0,"end":92},"obj":"Title"},{"id":"T2","span":{"begin":93,"end":1013},"obj":"Paragraph"},{"id":"T3","span":{"begin":43,"end":64},"obj":"Microorganism"},{"id":"T4","span":{"begin":93,"end":102},"obj":"Phenotype"},{"id":"T5","span":{"begin":163,"end":170},"obj":"Habitat"},{"id":"T6","span":{"begin":234,"end":243},"obj":"Phenotype"},{"id":"T7","span":{"begin":355,"end":370},"obj":"Phenotype"},{"id":"T8","span":{"begin":355,"end":360},"obj":"Habitat"},{"id":"T9","span":{"begin":372,"end":393},"obj":"Microorganism"},{"id":"T10","span":{"begin":723,"end":732},"obj":"Microorganism"},{"id":"T11","span":{"begin":866,"end":875},"obj":"Phenotype"},{"id":"E1","span":{"begin":372,"end":393},"obj":"Lives_In"},{"id":"E2","span":{"begin":372,"end":393},"obj":"Exhibits"}],"relations":[{"id":"R1","pred":"Microorganism","subj":"E1","obj":"T9"},{"id":"R2","pred":"Location","subj":"E1","obj":"T8"},{"id":"R3","pred":"Microorganism","subj":"E2","obj":"T9"},{"id":"R4","pred":"Property","subj":"E2","obj":"T7"}],"attributes":[{"id":"A5","pred":"OntoBiotope","subj":"T8","obj":"OBT:002488"},{"id":"A3","pred":"OntoBiotope","subj":"T5","obj":"OBT:001625"},{"id":"A2","pred":"OntoBiotope","subj":"T4","obj":"OBT:000375"},{"id":"A1","pred":"NCBI_Taxonomy","subj":"T3","obj":"1280"},{"id":"A7","pred":"NCBI_Taxonomy","subj":"T9","obj":"1280"},{"id":"A4","pred":"OntoBiotope","subj":"T6","obj":"OBT:000375"},{"id":"A8","pred":"NCBI_Taxonomy","subj":"T10","obj":"1280"},{"id":"A6","pred":"OntoBiotope","subj":"T7","obj":"OBT:002806"},{"id":"A9","pred":"OntoBiotope","subj":"T11","obj":"OBT:000375"}],"text":"Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH.\nPathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin (Hb) represents the largest reservoir of iron, and pathogens express Hb-binding proteins to access this source. Here, we show how one of the commonest and most significant human pathogens, Staphylococcus aureus, captures Hb as the first step of an iron-scavenging pathway. The x-ray crystal structure of Hb bound to a domain from the Isd (iron-regulated surface determinant) protein, IsdH, is the first structure of a Hb capture complex to be determined. Surface mutations in Hb that reduce binding to the Hb-receptor limit the capacity of S. aureus to utilize Hb as an iron source, suggesting that Hb sequence is a factor in host susceptibility to infection. The demonstration that pathogens make highly specific recognition complexes with Hb raises the possibility of developing inhibitors of Hb binding as antibacterial agents.\n\n"}