BB-kb+ner@ldeleger:BB-kb+ner-18687046 JSONTXT

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bionlp-ost-19-BB-kb-ner-train

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Id Subject Object Predicate Lexical cue OntoBiotope
T1 0-125 Title denotes Impact of intracranial pressure monitor prophylaxis on central nervous system infections and bacterial multi-drug resistance.
T2 126-586 Paragraph denotes Routine intracranial pressure monitor (ICP) prophylaxis is not practiced at our institution. Nevertheless, some patients receive de facto prophylaxis as a result of the use of antibiotics for injuries such as open or facial fractures. We tested the hypothesis that prophylactic antibiotics do not reduce the incidence of central nervous system (CNS) infections but instead are associated with the acquisition of multi-drug resistant (MDR) bacterial infections.
T3 587-1634 Paragraph denotes Patients admitted to the trauma intensive care unit (TICU) from January, 2001 through December, 2004 with blunt, non-operative traumatic brain injury who were managed solely with an ICP monitor were identified from our trauma registry and divided into two groups: (1) Those receiving no antibiotics prior to or during ICP monitoring (NONE; n = 71); and (2) those already receiving antibiotics at the time of ICP monitor insertion (PRO; n = 84). Groups were stratified on the basis of age, Injury Severity Score (ISS), Glasgow Coma Scale (GCS) Score, base excess (BE), ICP days, transfusions in 24 h, ICU days, ventilator days, head Abbreviated Injury Score (AIS), and chest AIS. The study groups did not differ with respect to age, ISS, GCS, BE, ICP days, 24-h transfusions, ICU days, ventilator days, head AIS, or length of stay. In all, 183 patients were identified, of whom 28 died within seven days and were excluded from the analysis. All patients were followed until discharge for both CNS infections and subsequent infectious complications.
T4 1635-2119 Paragraph denotes Only two patients, both in the PRO group, developed CNS infection. Both infectious complications (0.7 vs 1.4 per patient; p < 0.05) and infections secondary to MDR pathogens (0.03 vs. 0.33 per patient; p < 0.01) were significantly more common in the PRO group. Twenty-nine percent of the ventilator-associated pneumonias and 33% of the blood stream infections in the PRO group were MDR, whereas only two blood stream infections in the NONE group (4% of the total infections) were MDR.
T5 2120-2346 Paragraph denotes The routine use of prophylactic antibiotics for ICP monitor insertion is not warranted. This practice does not reduce the CNS infection rate and is associated with more MDR pathogens in any subsequent infectious complications.
T6 55-77 Habitat denotes central nervous system OBT:001028
T7 103-124 Phenotype denotes multi-drug resistance OBT:000598
T8 238-246 Habitat denotes patients OBT:003220
T9 318-326 Habitat denotes injuries OBT:000970
T10-1 335-339,350-359 Habitat denotes open fractures
T11 343-359 Habitat denotes facial fractures OBT:000526
T12 343-349 Habitat denotes facial OBT:001142
T13 447-469 Habitat denotes central nervous system OBT:001028
T14 471-474 Habitat denotes CNS OBT:001028
T15 538-558 Phenotype denotes multi-drug resistant OBT:000598
T16 560-563 Phenotype denotes MDR OBT:000598
T17 587-595 Habitat denotes Patients OBT:003220
T18 612-638 Habitat denotes trauma intensive care unit OBT:000328
T19 640-644 Habitat denotes TICU OBT:000328
T21 724-736 Habitat denotes brain injury OBT:000970
T20 724-729 Habitat denotes brain OBT:002689
T22 1187-1190 Habitat denotes ICU OBT:000328
T23 1362-1365 Habitat denotes ICU OBT:000328
T24 1430-1438 Habitat denotes patients OBT:003220
T25 1531-1539 Habitat denotes patients OBT:003220
T26 1579-1582 Habitat denotes CNS OBT:001028
T27 1644-1652 Habitat denotes patients OBT:003220
T28 1687-1690 Habitat denotes CNS OBT:001028
T29 1748-1755 Habitat denotes patient OBT:003220
T30 1795-1798 Phenotype denotes MDR OBT:000598
T31 1799-1808 Phenotype denotes pathogens OBT:000375
T32 1828-1835 Habitat denotes patient OBT:003220
T33 1971-1983 Habitat denotes blood stream OBT:000521
T34 2017-2020 Phenotype denotes MDR OBT:000598
T35 2039-2051 Habitat denotes blood stream OBT:000521
T36 2115-2118 Phenotype denotes MDR OBT:000598
T37 2242-2245 Habitat denotes CNS OBT:001028
T38 2289-2292 Phenotype denotes MDR OBT:000598
T39 2293-2302 Phenotype denotes pathogens OBT:000375