BB-kb+ner@ldeleger:BB-kb+ner-12109661 JSONTXT

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bionlp-ost-19-BB-kb-ner-dev

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T1 0-110 Title denotes Long-term Helicobacter pylori infection and the development of atrophic gastritis and gastric cancer in Japan.
T2 111-1577 Paragraph denotes The incidence of gastric cancer and the prevalence of Helicobacter pylori are high in Japan, so it is an important issue whether long-term H. pylori infection leads to chronic atrophic gastritis, considered one of the precursors of gastric cancer. We have reported that the grade of atrophy was higher in H. pylori-positive subjects than in H. pylori-negative subjects. It has also been reported that the atrophy of gastric mucosa increased in H. pylori-infected monkeys compared with control monkeys in a 5-year follow-up study. Most H. pylori infections occur in children, and atrophy of the gastric mucosa progresses during aging. Long-term data show that H. pylori infection can lead to gastric atrophy and may play an important role in the development of gastric cancer. Interestingly, there was no difference in the prevalence of H. pylori between patients with chronic gastritis and gastric cancer in Japan, but the prevalence of H. pylori in young Japanese gastric cancer patients was significantly higher than in the control group. These data clearly show that H. pylori infection is one of the risk factors of gastric cancer in young Japanese people, There is no answer to whether curing H. pylori infection can reverse the atrophy of the gastric mucosa and decrease the risk of gastric cancer development. To clarify this issue, an intervention study must be done. A large clinical trial called the Japanese Intervention Trial of H. pylori is in progress.
T3 10-29 Microorganism denotes Helicobacter pylori 210
T4 86-93 Habitat denotes gastric OBT:001792
T5 128-135 Habitat denotes gastric OBT:001792
T6 165-184 Microorganism denotes Helicobacter pylori 210
T7 250-259 Microorganism denotes H. pylori 210
T8 343-350 Habitat denotes gastric OBT:001792
T10 416-443 Habitat denotes H. pylori-positive subjects OBT:003269
T9 416-425 Microorganism denotes H. pylori 210
T12 452-479 Habitat denotes H. pylori-negative subjects OBT:002712
T11 452-461 Microorganism denotes H. pylori 210
T14 527-541 Habitat denotes gastric mucosa OBT:001577
T13 527-534 Habitat denotes gastric OBT:001792
T16 555-581 Habitat denotes H. pylori-infected monkeys OBT:000491|OBT:003107|OBT:000700
T15 555-564 Microorganism denotes H. pylori 210
T17 596-611 Habitat denotes control monkeys OBT:003107|OBT:000700
T18 646-655 Microorganism denotes H. pylori 210
T19 676-684 Habitat denotes children OBT:003188
T20 705-719 Habitat denotes gastric mucosa OBT:001577
T21 705-712 Habitat denotes gastric OBT:001792
T22 770-779 Microorganism denotes H. pylori 210
T23 802-809 Habitat denotes gastric OBT:001792
T24 871-878 Habitat denotes gastric OBT:001792
T25 947-956 Microorganism denotes H. pylori 210
T26 965-996 Habitat denotes patients with chronic gastritis OBT:003220
T27-1 965-978,1001-1015 Habitat denotes patients with gastric cancer
T28 1001-1008 Habitat denotes gastric OBT:001792
T29 1048-1057 Microorganism denotes H. pylori 210
T30 1061-1099 Habitat denotes young Japanese gastric cancer patients OBT:003188|OBT:003220
T31 1076-1083 Habitat denotes gastric OBT:001792
T32 1137-1150 Habitat denotes control group OBT:003188
T33 1181-1190 Microorganism denotes H. pylori 210
T34 1231-1238 Habitat denotes gastric OBT:001792
T35 1249-1270 Habitat denotes young Japanese people OBT:003188
T36 1309-1318 Microorganism denotes H. pylori 210
T38 1360-1374 Habitat denotes gastric mucosa OBT:001577
T37 1360-1367 Habitat denotes gastric OBT:001792
T39 1400-1407 Habitat denotes gastric OBT:001792
T40 1552-1561 Microorganism denotes H. pylori 210
E3 416-425 Lives_In denotes H. pylori
E4 555-564 Lives_In denotes H. pylori
E5 646-655 Lives_In denotes H. pylori
E6 947-956 Lives_In denotes H. pylori
E7 947-956 Lives_In denotes H. pylori
E9 1048-1057 Lives_In denotes H. pylori
E10 1181-1190 Lives_In denotes H. pylori
R1 E3 T9 Microorganism H. pylori,H. pylori
R2 E3 T10 Location H. pylori,H. pylori-positive subjects
R3 E4 T15 Microorganism H. pylori,H. pylori
R4 E4 T16 Location H. pylori,H. pylori-infected monkeys
R5 E5 T18 Microorganism H. pylori,H. pylori
R6 E5 T19 Location H. pylori,children
R7 E6 T25 Microorganism H. pylori,H. pylori
R8 E6 T27-0 Location H. pylori,
R9 E7 T25 Microorganism H. pylori,H. pylori
R10 E7 T26 Location H. pylori,patients with chronic gastritis
R11 E9 T29 Microorganism H. pylori,H. pylori
R12 E9 T30 Location H. pylori,young Japanese gastric cancer patients
R13 E10 T33 Microorganism H. pylori,H. pylori
R14 E10 T35 Location H. pylori,young Japanese people