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{"target":"https://pubannotation.org/docs/sourcedb/@dpavot/sourceid/28877067","sourcedb":"@dpavot","sourceid":"28877067","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/28877067","text":"We examined the diagnostic and prognostic value of altered reticulin framework and the immunoprofile of biomarkers including IGF-2, proteins involved in cell proliferation and mitotic spindle regulation (Ki67, p53, BUB1B, HURP, NEK2), DNA damage repair (PBK, γ-H2AX), telomere regulation (DAX, ATRX), wnt-signaling pathway (beta-catenin) and PI3K signaling pathway (PTEN, phospho-mTOR) in a tissue microarray of 50 adenomas and 43 carcinomas that were characterized for angioinvasion as defined by strict criteria, Weiss score, and mitotic rate-based tumor grade.","tracks":[{"project":"PGR-FAL","denotations":[{"id":"T1","span":{"begin":228,"end":232},"obj":"4751"},{"id":"T2","span":{"begin":431,"end":441},"obj":"HP:0030731"}],"relations":[{"id":"R1","pred":"false","subj":"T2","obj":"T1"}],"attributes":[{"subj":"T1","pred":"source","obj":"PGR-FAL"},{"subj":"T2","pred":"source","obj":"PGR-FAL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PGR-FAL","color":"#a293ec","default":true}]}]}}