2020PubMed@AikoHIRAKI:re32744052 JSONTXT

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Covid19_manual_annotation

Id Subject Object Predicate Lexical cue ForCovid19 Memo correct/standard/original word tao:has_database_id typo
10 37-45 Disease denotes COVID-19 MESH:C000657245
100 919-933 Species denotes coronavirus-19 Tax:2697049
101 1079-1102 Disease denotes respiratory dysfunction MESH:D012131
102 1104-1112 Species denotes Patients Tax:9606
103 1118-1126 Disease denotes COVID-19 MESH:C000657245
104 1195-1207 Disease denotes inflammation MESH:D007249
105 1209-1235 Disease denotes intravascular coagulopathy MESH:D004211
106 1254-1278 Disease denotes thrombotic complications MESH:D013927
107 1284-1306 Disease denotes venous thromboembolism MESH:D054556
108 1335-1339 Gene denotes IL-1 Gene:3552
109 1344-1358 Species denotes these patients Tax:9606
11 54-66 Disease denotes inflammation MESH:D007249
110 1473-1483 Biological denotes fibrinogen MESH:D005340
111 1520-1539 Disease denotes respiratory failure MESH:D012131
112 1563-1567 Gene denotes IL-1 Gene:3552
113 1637-1640 Gene denotes TNF Gene:7124
114 1699-1713 Disease denotes shock syndrome MESH:D012769
115 1717-1725 Disease denotes COVID-19 MESH:C000657245
116 1732-1736 Gene denotes IL-1 Gene:3552
117 1741-1744 Gene denotes TNF Gene:7124
118 1751-1766 Disease denotes pulmonary edema MESH:D011654
12 111-135 Gene denotes IL-1 receptor antagonist Gene:3557
120 1808-1819 Disease denotes hypotension MESH:D007022
121 1863-1867 Gene denotes IL-1 Gene:3552
122 1875-1885 Disease denotes leukopenia MESH:D007970
123 1890-1906 Disease denotes thrombocytopenia MESH:D013921
124 2067-2076 Die denotes mortality MESH:D009026
125 2078-2082 Gene denotes IL-1 Gene:3552
127 2186-2200 Biological denotes thromboxane A2 MESH:D013928
128 2250-2254 Gene denotes IL-1 Gene:3552
129 2305-2310 Disease denotes fever MESH:D005334
13 137-143 Gene denotes IL-1Ra Gene:3557
130 2354-2370 Biological denotes arachidonic acid MESH:D016718
132 2461-2471 Disease denotes thrombosis MESH:D013927
133 2482-2494 Disease denotes inflammation MESH:D007249
134 2716-2730 Chemical denotes thromboxane B2 MESH:D013929
135 2808-2813 Species denotes human Tax:9606
137 2916-2920 Gene denotes IL-1 Gene:3552
138 2929-2943 Biological denotes thromboxane B2 MESH:D013929
139 2945-2949 Biological denotes TxB2 MESH:D013929
140 3017-3028 Chemical denotes thromboxane MESH:D013931
141 3075-3087 Disease denotes inflammation MESH:D007249
142 3148-3165 Disease denotes organ dysfunction MESH:D009102
143 3174-3178 Gene denotes IL-1 Gene:3552
144 3384-3394 Biological denotes ecosanoids
145 3403-3407 Biological denotes TxA2 MESH:D013928
146 3462-3474 Disease denotes inflammation MESH:D007249
147 3479-3499 Biological denotes platelet aggregation
148 3571-3579 Disease denotes COVID-19 MESH:C000657245
149 3624-3646 Biological denotes clotting abnormalities
150 3725-3744 Disease denotes thrombotic diseases MESH:D013927
151 3817-3821 Gene denotes IL-1 Gene:3552
152 3870-3874 Biological denotes TxA2 MESH:D013928
153 4039-4043 Gene denotes IL-1 Gene:3552
154 4084-4088 Gene denotes IL-1 Gene:3552
155 4148-4153 Die denotes death MESH:D003643
156 4161-4168 Species denotes patient Tax:9606
157 4217-4221 Gene denotes IL-1 negative Gene:3552
158 4227-4251 Gene denotes IL-1 receptor antagonist inhibitor Gene:3557
159 4253-4259 Gene denotes IL-1Ra inhibitor Gene:3557
160 4292-4304 Disease denotes septic shock MESH:D012772
161 4315-4327 Disease denotes inflammation MESH:D007249
162 4374-4382 Disease denotes COVID-19 MESH:C000657245
163 4394-4404 Species denotes SARS-CoV-2 Tax:2697049
7 0-4 Gene denotes IL-1 Gene:3552
8 13-26 Biological denotes throboxane-A2 MESH:D013928
89 147-151 Gene denotes IL-1 Gene:3552
9 28-32 Biological denotes TxA2 MESH:D013928
91 268-279 Disease denotes hypotension MESH:D007022
92 409-413 Gene denotes IL-1 Gene:3552
93 421-444 Disease denotes endothelial dysfunction MESH:C536439
96 760-764 Gene denotes IL-1 Gene:3552
98 854-864 Species denotes SARS-CoV-2 Tax:2697049
99 880-888 Disease denotes COVID-19 MESH:C000657245
T1 71-84 Disease denotes micro-thrombi
T100 293-302 Decrease denotes reduction
T101 287-292 Severity denotes rapid
T102 331-338 Decrease denotes reduced
T103 360-369 Increase denotes increased
T104 525-534 Disease denotes infection MESH:D007239
T105 516-524 Species denotes pathogen
T106 607-614 Biological denotes protein
T107 615-627 Property denotes permeability MESH:D010539
T108 580-592 Function denotes intervention
T109 832-842 Disease denotes infections MESH:D007239
T110 815-831 Species denotes pathogenic viral
T111 768-787 Disease denotes various pathologies
T112 747-756 Induce denotes induction
T113 715-728 Result denotes These effects
T115 890-900 Activate denotes Activation
T116 904-915 Biological denotes macrophages
T117 975-984 Biological denotes cytokines
T118 1146-1176 Status_of_Care denotes hospitalized in intensive care
T119 1178-1185 Show denotes present
T12 536-552 Disease denotes This dysfunction MESH:C536439
T121 1425-1433 Increase denotes increase
T122 1391-1403 Target denotes target organ
T123 1568-1575 PositiveRegulation denotes induces
T125 1576-1582 Gene denotes itself Gene:3552
T126 1610-1626 Type denotes pro-inflammatory
T127 1945-1957 Disease denotes complication comorbidity
T128 1965-1983 Biological denotes circulatory system
T129 1988-2001 Function denotes functionality
T13 674-683 Biological denotes cytokines
T130 2009-2014 Biological denotes organ
T131 2090-2098 Biological denotes platelet
T132 2099-2107 Biological denotes vascular
T133 2108-2123 Function denotes thrombogenicity
T134 2173-2182 Function denotes formation
T135 2157-2168 PositiveRegulation denotes stimulating
T136 2210-2218 Release denotes released
T138 2377-2386 Increase denotes increases
T139 2340-2350 Metabolism denotes metabolism
T14 688-713 Biological denotes arachidonic acid products
T140 2731-2738 Release denotes release
T141 2707-2715 PositiveRegulation denotes enhanced
T142 2921-2928 PositiveRegulation denotes induces
T143 2951-2959 Release denotes releases
T144 3040-3061 Biological denotes leukocyte aggregation
T146 3005-3013 Increase denotes increase
T147 3179-3189 PositiveRegulation denotes stimulates
T148 3190-3206 Biological denotes endothelial cell
T149 3207-3216 Biological denotes leukocyte
T15 569-579 Biological denotes macrophage
T150 3231-3235 Biological denotes TxB2 MESH:D013929
T151 3236-3246 Produce denotes production
T152 3421-3425 Biological denotes TxB2 MESH:D013929
T153 3348-3356 Decrease denotes decrease
T154 3335-3339 Biological denotes lung
T155 3292-3300 Increase denotes increase
T156 3321-3327 Bind denotes adhere
T158 3602-3618 Biological denotes cell aggregation
T159 3409-3417 Detect denotes detected
T16 597-606 Increase denotes increased
T160 3699-3709 BecomeReduce denotes prevention
T161 3806-3813 Induce denotes induced
T162 3746-3756 Prevent denotes Prevention
T163 3763-3772 Induce denotes induction
T164 3781-3787 Prevent denotes avoids
T165 3906-3915 Difficult denotes difficult
T166 3919-3926 NegativeRegulation denotes inhibit
T167 3966-3973 NegativeRegulation denotes prevent
T168 3978-3987 Induce denotes induction
T169 3992-4002 Produce denotes generation
T17 947-954 Increase denotes release
T170 4019-4028 Induce denotes inductors
T171 3848-3863 Biological denotes vascular events
T172 3840-3847 Severity denotes serious
T173 3951-3962 Easy denotes much better
T174 4089-4095 BecomeReduce denotes avoids
T175 4187-4206 Biological denotes innate immune cells
T176 4207-4216 Produce denotes producing
T177 4265-4270 NegativeRegulation denotes avoid
T178 4174-4183 Therapy denotes treatment
T18 958-974 Type denotes pro-inflammatory
T19 986-1004 Biological denotes metalloproteinases
T2 212-219 Change denotes changes
T20 1009-1034 Biological denotes other proteolytic enzymes
T21 1072-1078 Severity denotes severe
T22 1050-1067 Disease denotes thrombi formation
T23 1128-1141 Severity denotes seriously ill
T24 1186-1194 Severity denotes systemic
T25 1241-1250 BecomeSevere denotes high risk
T26 1363-1368 Biological denotes lungs
T27 1502-1515 Disease denotes organ lesions
T28 1488-1495 Biological denotes D-dimer MESH:C036309
T3 198-211 Biological denotes hematological
T30 1441-1461 Biological denotes degradation products
T31 1465-1471 Biological denotes fibrin MESH:D005337
T32 1627-1635 Biological denotes cytokine
T34 1768-1778 Disease denotes thrombosis MESH:D013927
T36 1783-1791 Disease denotes bleeding MESH:D006470
T37 1824-1861 Disease denotes resistance of systemic blood pressure May be "http://purl.obolibrary.org/obo/HP_0030972".
T38 1912-1932 Biological denotes formation of thrombi
T39 3126-3143 Disease denotes thrombi formation
T4 184-193 Biological denotes metabolic
T40 3515-3535 Biological denotes formation of thrombi
T41 3788-3805 Biological denotes thrombi formation
T42 2053-2062 Index denotes morbidity MESH:D009017
T43 2132-2153 Biological denotes non-endothelial cells
T44 2228-2248 Biological denotes inflamed environment
T45 2427-2439 Biological denotes hypothalamus
T46 2392-2419 Biological denotes vascular endothelial organs
T47 2570-2593 Gene denotes thromboxane A2 receptor Gene:6915
T49 2499-2510 Biological denotes angigenesis angiogenesis t
T5 306-329 Biological denotes systemic blood pressure
T50 2541-2551 Activate denotes activation
T51 2473-2481 Biological denotes vascular
T52 2963-2972 Activate denotes activated
T53 2973-2984 Biological denotes neutrophils
T54 2989-3000 Biological denotes macrophages
T57 2826-2839 Gene denotes interleukin 1 Gene:3552
T58 2814-2825 Recombinant denotes recombinant
T6 339-358 Biological denotes vascular resistance
T61 2775-2786 Biological denotes macrophages
T62 2742-2770 Biological denotes polymorphonuclear leukocytes
T64 3066-3074 Severity denotes systemic
T65 3117-3125 Severity denotes dramatic
T66 3217-3225 Bind denotes adhesion
T68 2698-2706 Condition denotes In vitro
T69 3304-3315 Biological denotes neutrophils
T7 251-261 Therapy denotes treatments
T70 3360-3371 Biological denotes lymphocytes
T71 3453-3461 Biological denotes vascular
T73 3776-3780 Biological denotes TxA2 MESH:D013928
T74 3541-3555 Biological denotes thrombogenesis May be MESH:D013927?
T75 3589-3597 Biological denotes platelet
T76 3607-3618 Biological denotes aggregation
T78 3652-3682 Chemical denotes anti-clotting inhibitor agents inhibitor|drug
T8 370-380 Biological denotes heart rate
T82 4006-4014 Prevent denotes blocking
T83 3885-3898 Severity denotes significantly
T84 3875-3884 Increase denotes increases
T85 4071-4080 Structure denotes formation
T86 4049-4059 NegativeRegulation denotes inhibition
T87 4063-4067 Cleave denotes lack
T88 4309-4314 Biological denotes organ
T9 385-407 Biological denotes leukocyte aggregations
T90 4271-4290 Biological denotes hemodynamic changes
T93 5-12 PositiveRegulation denotes induces
T94 97-103 Result denotes effect
T95 86-96 Negative denotes inhibitory
T96 152-159 PositiveRegulation denotes induces
T97 224-244 Species denotes experimental animals
T99 246-250 Gene denotes IL-1 Gene:3552
R1 159 158 abbreviation IL-1Ra,IL-1 receptor antagonist
R2 139 138 abbreviation TxB2,thromboxane B2
R3 T75 T76 - platelet,aggregation
R4 9 8 abbreviation TxA2,throboxane-A2
R6 7 T93 is_a IL-1,induces
R125 T143 T53 to releases,neutrophils
R126 T143 T54 to releases,macrophages
R127 T52 T53 is_a activated,neutrophils
R128 T52 T54 is_a activated,macrophages
R129 T57 T141 using interleukin 1,enhanced
R130 T50 T47 is_a activation,thromboxane A2 receptor
R131 T47 133 cause_of thromboxane A2 receptor,inflammation
R132 T47 T49 cause_of thromboxane A2 receptor,angigenesis
R133 T47 132 cause_of thromboxane A2 receptor,thrombosis
R134 T146 140 is_a increase,thromboxane
R151 144 146 cause_of ecosanoids,inflammation
R5 13 12 abbreviation IL-1Ra,IL-1 receptor antagonist
R7 T93 8 is_a induces,throboxane-A2
R8 8 11 cause_of throboxane-A2,inflammation
R9 8 T1 cause_of throboxane-A2,micro-thrombi
R10 89 T96 is_a IL-1,induces
R11 T96 T2 is_a induces,changes
R12 T4 T2 of_a metabolic,changes
R13 T3 T2 of_a hematological,changes
R14 T99 T7 of_a IL-1,treatments
R15 T7 T100 is_a treatments,reduction
R16 T100 T5 is_a reduction,systemic blood pressure
R17 T7 T102 is_a treatments,reduced
R18 T102 T6 is_a reduced,vascular resistance
R19 T7 T103 is_a treatments,increased
R20 T103 T8 is_a increased,heart rate
R21 T103 T9 is_a increased,leukocyte aggregations
R22 T100 91 cause_of reduction,hypotension
R23 T102 91 cause_of reduced,hypotension
R24 T103 91 cause_of increased,hypotension
R25 T101 T100 of_a rapid,reduction
R26 92 93 cause_of IL-1,endothelial dysfunction
R27 T105 T104 cause_of pathogen,infection
R28 T12 93 coreference This dysfunction,endothelial dysfunction
R29 T106 T107 of_a protein,permeability
R30 T16 T107 is_a increased,permeability
R31 T15 T108 of_a macrophage,intervention
R32 96 T112 is_a IL-1,induction
R33 T112 T113 is_a induction,These effects
R34 T113 T108 coreference These effects,intervention
R35 T113 T107 coreference These effects,permeability
R36 T110 T109 cause_of pathogenic viral,infections
R37 98 99 cause_of SARS-CoV-2,COVID-19
R38 T109 96 cause_of infections,IL-1
R39 99 96 cause_of COVID-19,IL-1
R40 100 T115 is_a coronavirus-19,Activation
R41 T115 T116 is_a Activation,macrophages
R42 T116 T17 is_a macrophages,release
R43 T17 T117 is_a release,cytokines
R44 T17 T19 is_a release,metalloproteinases
R45 T17 T20 is_a release,other proteolytic enzymes
R46 T117 T22 cause_of cytokines,thrombi formation
R47 T19 T22 cause_of metalloproteinases,thrombi formation
R48 T20 T22 cause_of other proteolytic enzymes,thrombi formation
R49 T18 T117 of_a pro-inflammatory,cytokines
R50 T117 101 cause_of cytokines,respiratory dysfunction
R51 T19 101 cause_of metalloproteinases,respiratory dysfunction
R52 T20 101 cause_of other proteolytic enzymes,respiratory dysfunction
R53 T21 101 of_a severe,respiratory dysfunction
R54 105 T25 is_a intravascular coagulopathy,high risk
R55 T25 106 is_a high risk,thrombotic complications
R56 T25 107 is_a high risk,venous thromboembolism
R57 T24 104 of_a systemic,inflammation
R58 108 104 cause_of IL-1,inflammation
R59 108 105 cause_of IL-1,intravascular coagulopathy
R60 103 102 has_a COVID-19,Patients
R61 T23 103 of_a seriously ill,COVID-19
R62 103 T118 has_status COVID-19,hospitalized in intensive care
R63 109 102 coreference these patients,Patients
R64 T122 T26 is_a target organ,lungs
R65 T121 T30 is_a increase,degradation products
R66 T31 T30 of_a fibrin,degradation products
R67 T31 T30 of_a fibrin,degradation products
R68 T28 T30 of_a D-dimer,degradation products
R69 T30 T27 cause_of degradation products,organ lesions
R70 T30 111 cause_of degradation products,respiratory failure
R71 T26 T121 in lungs,increase
R72 109 T26 of_a these patients,lungs
R73 112 T123 is_a IL-1,induces
R74 T123 T125 is_a induces,itself
R75 T125 112 coreference itself,IL-1
R76 T123 113 is_a induces,TNF
R77 T126 T32 of_a pro-inflammatory,cytokine
R78 113 114 cause_of TNF,shock syndrome
R79 116 118 cause_of IL-1,pulmonary edema
R80 116 T34 cause_of IL-1,thrombosis
R81 116 T36 cause_of IL-1,bleeding
R82 117 118 cause_of TNF,pulmonary edema
R83 117 T34 cause_of TNF,thrombosis
R84 117 T36 cause_of TNF,bleeding
R85 121 122 cause_of IL-1,leukopenia
R86 121 123 cause_of IL-1,thrombocytopenia
R87 121 T37 cause_of IL-1,resistance of systemic blood pressure
R88 121 120 cause_of IL-1,hypotension
R89 T130 T129 of_a organ,functionality
R90 T129 T127 of_a functionality,complication
R91 T128 T127 of_a circulatory system,complication
R92 T38 T42 cause_of formation of thrombi,morbidity
R93 T38 124 cause_of formation of thrombi,mortality
R94 T127 T38 is_a complication,formation of thrombi
R95 125 T135 is_a IL-1,stimulating
R96 T135 T134 is_a stimulating,formation
R97 T134 127 is_a formation,thromboxane A2
R98 T132 T133 on vascular,thrombogenicity
R99 T43 T133 on non-endothelial cells,thrombogenicity
R100 T131 T133 of_a platelet,thrombogenicity
R101 T135 T133 cause_of stimulating,thrombogenicity
R102 127 T136 is_a thromboxane A2,released
R103 T136 T44 to released,inflamed environment
R104 T45 T46 of_a hypothalamus,vascular endothelial organs
R105 T46 T138 from vascular endothelial organs,increases
R106 130 T138 is_a arachidonic acid,increases
R107 128 T139 cause_of IL-1,metabolism
R108 T139 129 cause_of metabolism,fever
R109 130 T139 of_a arachidonic acid,metabolism
R110 T51 133 of_a vascular,inflammation
R115 T58 T57 is_a recombinant,interleukin 1
R116 135 T57 of_a human,interleukin 1
R117 T62 T141 is_a polymorphonuclear leukocytes,enhanced
R118 T141 T140 is_a enhanced,release
R119 T140 134 is_a release,thromboxane B2
R120 T61 T141 is_a macrophages,enhanced
R121 T68 T141 of_a In vitro,enhanced
R122 137 T142 is_a IL-1,induces
R123 T142 T143 is_a induces,releases
R124 T143 138 is_a releases,thromboxane B2
R135 140 T144 cause_of thromboxane,leukocyte aggregation
R136 140 141 cause_of thromboxane,inflammation
R137 T64 141 of_a systemic,inflammation
R138 140 T39 cause_of thromboxane,thrombi formation
R139 140 142 cause_of thromboxane,organ dysfunction
R140 T65 T39 of_a dramatic,thrombi formation
R141 143 T147 is_a IL-1,stimulates
R142 T147 T66 is_a stimulates,adhesion
R143 T148 T66 of_a endothelial cell,adhesion
R144 T149 T66 of_a leukocyte,adhesion
R145 143 T151 is_a IL-1,production
R146 T151 T150 is_a production,TxB2
R147 T69 T156 is_a neutrophils,adhere
R148 T156 T154 to adhere,lung
R149 T155 T69 is_a increase,neutrophils
R150 T153 T70 is_a decrease,lymphocytes
R152 T71 146 of_a vascular,inflammation
R153 144 147 cause_of ecosanoids,platelet aggregation
R154 145 146 cause_of TxA2,inflammation
R155 145 147 cause_of TxA2,platelet aggregation
R156 T152 146 cause_of TxB2,inflammation
R157 T152 147 cause_of TxB2,platelet aggregation
R158 144 T40 cause_of ecosanoids,formation of thrombi
R159 145 T40 cause_of TxA2,formation of thrombi
R160 T152 T40 cause_of TxB2,formation of thrombi
R161 T78 T160 is_a anti-clotting inhibitor agents,prevention
R162 T160 150 is_a prevention,thrombotic diseases
R163 T160 149 is_a prevention,clotting abnormalities
R164 T160 T158 is_a prevention,cell aggregation
R165 T160 T75 is_a prevention,platelet
R166 T167 153 is_a prevent,IL-1
R167 T166 152 is_a inhibit,TxA2
R168 T165 T166 is_a difficult,inhibit
R169 T173 T167 is_a much better,prevent
R170 T165 T173 against difficult,much better
R171 T86 154 is_a inhibition,IL-1
R172 154 T174 is_a IL-1,avoids
R173 T174 155 is_a avoids,death
R174 155 156 is_a death,patient
R175 158 T177 is_a IL-1 receptor antagonist,avoid
R176 T177 T90 is_a avoid,hemodynamic changes
R177 T177 160 is_a avoid,septic shock
R178 T177 161 is_a avoid,inflammation
R179 T88 161 of_a organ,inflammation
R180 163 162 cause_of SARS-CoV-2,COVID-19
R181 162 T90 cause_of COVID-19,hemodynamic changes
R182 162 160 cause_of COVID-19,septic shock
R183 162 161 cause_of COVID-19,inflammation