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Id Subject Object Predicate Lexical cue
T1 0-134 Sentence denotes Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.
T1 0-134 Sentence denotes Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.
T2 135-279 Sentence denotes Tissue-specific expression of interleukin-3 (IL-3) is mediated via cis-acting elements located within 315 base pairs of the transcription start.
T2 135-279 Sentence denotes Tissue-specific expression of interleukin-3 (IL-3) is mediated via cis-acting elements located within 315 base pairs of the transcription start.
T3 280-386 Sentence denotes This is achieved in part through the positive activities of the AP-1 and Elf-1 sites in the IL-3 promoter.
T3 280-386 Sentence denotes This is achieved in part through the positive activities of the AP-1 and Elf-1 sites in the IL-3 promoter.
T4 387-672 Sentence denotes The contribution to T cell-specific expression by other promoter sites was assessed in a transient expression assay with IL-3 promoter constructs linked to a luciferase gene, focusing initially on the core binding factor (CBF) site, which is footprinted in vivo upon T cell activation.
T4 387-672 Sentence denotes The contribution to T cell-specific expression by other promoter sites was assessed in a transient expression assay with IL-3 promoter constructs linked to a luciferase gene, focusing initially on the core binding factor (CBF) site, which is footprinted in vivo upon T cell activation.
T5 673-771 Sentence denotes Activity of the CBF site is shown to be critically dependent on the adjacent activator site Act-1.
T5 673-771 Sentence denotes Activity of the CBF site is shown to be critically dependent on the adjacent activator site Act-1.
T6 772-857 Sentence denotes Together the Act-1 and CBF sites form a functional unit (AC unit) with dual activity.
T6 772-857 Sentence denotes Together the Act-1 and CBF sites form a functional unit (AC unit) with dual activity.
T7 858-957 Sentence denotes The AC unit is demonstrated to enhance basal activity of promoters both in fibroblasts and T cells.
T7 858-957 Sentence denotes The AC unit is demonstrated to enhance basal activity of promoters both in fibroblasts and T cells.
T8 958-1038 Sentence denotes This activity is further inducible in activated T cells, but not in fibroblasts.
T8 958-1038 Sentence denotes This activity is further inducible in activated T cells, but not in fibroblasts.
T9 1039-1197 Sentence denotes In addition to the already identified NIP repressor site, evidence is presented for a second repressor region that restricts promoter activity in fibroblasts.
T9 1039-1197 Sentence denotes In addition to the already identified NIP repressor site, evidence is presented for a second repressor region that restricts promoter activity in fibroblasts.
T10 1198-1359 Sentence denotes Finally, a novel positive regulatory element has been mapped in the IL-3 promoter between nucleotide -180 and -210 that leads to increased expression in T cells.
T10 1198-1359 Sentence denotes Finally, a novel positive regulatory element has been mapped in the IL-3 promoter between nucleotide -180 and -210 that leads to increased expression in T cells.
T11 1360-1653 Sentence denotes Together these results demonstrate that T cell expression of IL-3 is not specified by the activity of a single tissue-specific element, but instead involves multiple interacting elements that provide both specific positive regulation in T cells and specific negative regulation in fibroblasts.
T11 1360-1653 Sentence denotes Together these results demonstrate that T cell expression of IL-3 is not specified by the activity of a single tissue-specific element, but instead involves multiple interacting elements that provide both specific positive regulation in T cells and specific negative regulation in fibroblasts.