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PubMed:19358333 JSONTXT 16 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndrome.
T1 0-111 Sentence denotes Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndrome.
TextSentencer_T2 112-227 Sentence denotes Recent studies have demonstrated an association between mutations in CACNA1c or CACNB2b and Brugada syndrome (BrS).
T2 112-227 Sentence denotes Recent studies have demonstrated an association between mutations in CACNA1c or CACNB2b and Brugada syndrome (BrS).
TextSentencer_T3 228-346 Sentence denotes Previously described mutations all caused a loss of function secondary to a reduction of peak calcium current (I(Ca)).
T3 228-346 Sentence denotes Previously described mutations all caused a loss of function secondary to a reduction of peak calcium current (I(Ca)).
TextSentencer_T4 347-477 Sentence denotes We describe a novel CACNB2b mutation associated with BrS in which loss of function is caused by accelerated inactivation of I(Ca).
T4 347-477 Sentence denotes We describe a novel CACNB2b mutation associated with BrS in which loss of function is caused by accelerated inactivation of I(Ca).
TextSentencer_T5 478-620 Sentence denotes The proband, a 32 year old male, displayed a Type I ST segment elevation in two right precordial ECG leads following a procainamide challenge.
T5 478-620 Sentence denotes The proband, a 32 year old male, displayed a Type I ST segment elevation in two right precordial ECG leads following a procainamide challenge.
TextSentencer_T6 621-679 Sentence denotes EP study was positive with induction of polymorphic VT/VF.
T6 621-679 Sentence denotes EP study was positive with induction of polymorphic VT/VF.
TextSentencer_T7 680-773 Sentence denotes Interrogation of implanted ICD revealed brief episodes of very rapid ventricular tachycardia.
T7 680-773 Sentence denotes Interrogation of implanted ICD revealed brief episodes of very rapid ventricular tachycardia.
TextSentencer_T8 774-819 Sentence denotes He was also diagnosed with vasovagal syncope.
T8 774-819 Sentence denotes He was also diagnosed with vasovagal syncope.
TextSentencer_T9 820-862 Sentence denotes Genomic DNA was isolated from lymphocytes.
T9 820-862 Sentence denotes Genomic DNA was isolated from lymphocytes.
TextSentencer_T10 863-945 Sentence denotes All exons and intron borders of 15 ion channel genes were amplified and sequenced.
T10 863-945 Sentence denotes All exons and intron borders of 15 ion channel genes were amplified and sequenced.
TextSentencer_T11 946-1016 Sentence denotes The only mutation uncovered was a missense mutation (T11I) in CACNB2b.
T11 946-1016 Sentence denotes The only mutation uncovered was a missense mutation (T11I) in CACNB2b.
TextSentencer_T12 1017-1108 Sentence denotes We expressed WT or T11I CACNB2b in TSA201 cells co-transfected with WT CACNA1c and CACNA2d.
T12 1017-1108 Sentence denotes We expressed WT or T11I CACNB2b in TSA201 cells co-transfected with WT CACNA1c and CACNA2d.
TextSentencer_T13 1109-1262 Sentence denotes Patch clamp analysis showed no significant difference between WT and T11I in peak I(Ca) density, steady-state inactivation or recovery from inactivation.
T13 1109-1262 Sentence denotes Patch clamp analysis showed no significant difference between WT and T11I in peak I(Ca) density, steady-state inactivation or recovery from inactivation.
TextSentencer_T14 1263-1374 Sentence denotes However, both fast and slow decays of I(Ca) were significantly faster in mutant channels between 0 and + 20 mV.
T14 1263-1374 Sentence denotes However, both fast and slow decays of I(Ca) were significantly faster in mutant channels between 0 and + 20 mV.
TextSentencer_T15 1375-1485 Sentence denotes Action potential voltage clamp experiments showed that total charge was reduced by almost half compared to WT.
T15 1375-1485 Sentence denotes Action potential voltage clamp experiments showed that total charge was reduced by almost half compared to WT.
TextSentencer_T16 1486-1602 Sentence denotes We report the first BrS mutation in CaCNB2b resulting in accelerated inactivation of L-type calcium channel current.
T16 1486-1602 Sentence denotes We report the first BrS mutation in CaCNB2b resulting in accelerated inactivation of L-type calcium channel current.
TextSentencer_T17 1603-1720 Sentence denotes Our results suggest that the faster current decay results in a loss-of-function responsible for the Brugada phenotype
T17 1603-1720 Sentence denotes Our results suggest that the faster current decay results in a loss-of-function responsible for the Brugada phenotype