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PMC:2817507 / 15746-17947 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T6219 0-148 Sentence denotes Recent studies demonstrated that ICH initiates inflammatory responses, which are associated with secondary growth of hemorrhage and cell death [18].
T153 0-148 Sentence denotes Recent studies demonstrated that ICH initiates inflammatory responses, which are associated with secondary growth of hemorrhage and cell death [18].
T6220 149-265 Sentence denotes It is now believed that TLR4-mediated-NFκB pathway activates and regulates immunological and inflammatory responses.
T154 149-265 Sentence denotes It is now believed that TLR4-mediated-NFκB pathway activates and regulates immunological and inflammatory responses.
T6221 266-520 Sentence denotes To investigate the mechanisms underlying the increased inflammatory responses in the brain after ICH, in the present study, we evaluated the activation of TLR4-mediated NFκB signaling by detecting the p-IκB and the activity of NFκB in hemorrhagic brains.
T155 266-520 Sentence denotes To investigate the mechanisms underlying the increased inflammatory responses in the brain after ICH, in the present study, we evaluated the activation of TLR4-mediated NFκB signaling by detecting the p-IκB and the activity of NFκB in hemorrhagic brains.
T6222 521-613 Sentence denotes NFκB is an important transcription factor downstream in the TLR4-mediated signaling pathway.
T156 521-613 Sentence denotes NFκB is an important transcription factor downstream in the TLR4-mediated signaling pathway.
T6223 614-829 Sentence denotes Activation of TLR4 stimulates IκBα phosphorylation and degradation, resulting in nuclear translocation of NFκB, which initiates transcription of genes associated with innate immune responses and inflammation [5, 6].
T157 614-829 Sentence denotes Activation of TLR4 stimulates IκBα phosphorylation and degradation, resulting in nuclear translocation of NFκB, which initiates transcription of genes associated with innate immune responses and inflammation [5, 6].
T6224 830-964 Sentence denotes We observed that the levels of phosphorylation of IκB and the activity of NFκB were significantly increased in brain tissue after ICH.
T158 830-964 Sentence denotes We observed that the levels of phosphorylation of IκB and the activity of NFκB were significantly increased in brain tissue after ICH.
T6225 965-1086 Sentence denotes The temporal profile of the expression of p-IκB and the activation of NFκB was similar to that of the expression of TLR4.
T159 965-1086 Sentence denotes The temporal profile of the expression of p-IκB and the activation of NFκB was similar to that of the expression of TLR4.
T6226 1087-1294 Sentence denotes Our data suggest that ICH stimulates activation of the TLR4/NFκB signaling pathway, which is consistent with previous reports that activation of NFκB is regulated through the TLR4-mediated signaling pathway.
T160 1087-1294 Sentence denotes Our data suggest that ICH stimulates activation of the TLR4/NFκB signaling pathway, which is consistent with previous reports that activation of NFκB is regulated through the TLR4-mediated signaling pathway.
T6227 1295-1607 Sentence denotes TLR4 plays an important role in the recognition of microbial components [19, 20] and can also recognize endogenous molecules such as the degradation products of macromolecules, products of proteolytic cascades, intracellular components of ruptured cells, and products of genes that are activated by inflammation.
T161 1295-1607 Sentence denotes TLR4 plays an important role in the recognition of microbial components [19, 20] and can also recognize endogenous molecules such as the degradation products of macromolecules, products of proteolytic cascades, intracellular components of ruptured cells, and products of genes that are activated by inflammation.
T6228 1608-1804 Sentence denotes For instance, HSP70, HSP32, HSP27, and enzymes involved in oxidative stress are found to be upregulated in the brain after ICH, which may be produced by injured neuronal cells or blood cells [21].
T162 1608-1804 Sentence denotes For instance, HSP70, HSP32, HSP27, and enzymes involved in oxidative stress are found to be upregulated in the brain after ICH, which may be produced by injured neuronal cells or blood cells [21].
T6229 1805-2052 Sentence denotes It may be speculated that these molecules produced in damaged brain or came from blood cells and constituents of plasma server as endogenous TLR4 ligands, activate TLR4-mediated NFκB signaling, and initiate the inflammatory responses in IHC brain.
T163 1805-2052 Sentence denotes It may be speculated that these molecules produced in damaged brain or came from blood cells and constituents of plasma server as endogenous TLR4 ligands, activate TLR4-mediated NFκB signaling, and initiate the inflammatory responses in IHC brain.
T6230 2053-2200 Sentence denotes However, the specific endogenous ligands for TLR4 in hemorrhagic brain have not been determined and need to be identified through further research.
T164 2053-2200 Sentence denotes However, the specific endogenous ligands for TLR4 in hemorrhagic brain have not been determined and need to be identified through further research.