pubmed-sentences-benchmark  

PubMed:7853483 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
S1 0-124 Sentence denotes Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus.
S2 125-254 Sentence denotes The mechanisms regulating human immunodeficiency virus (HIV) persistence in human monocytes/macrophages are partially understood.
S3 255-337 Sentence denotes Persistent HIV infection of U937 monocytic cells results in NF-kappa B activation.
S4 338-469 Sentence denotes Whether virus-induced NF-kappa B activation is a mechanism that favors continuous viral replication in macrophages remains unknown.
S5 470-661 Sentence denotes To further delineate the molecular mechanisms involved in the activation of NF-kappa B in HIV-infected monocytes and macrophages, we have focused on the regulation of the I kappa B molecules.
S6 662-799 Sentence denotes First, we show that persistent HIV infection results in the activation of NF-kappa B not only in monocytic cells but also in macrophages.
S7 800-910 Sentence denotes In HIV-infected cells, I kappa B alpha protein levels are decreased secondary to enhanced protein degradation.
S8 911-1099 Sentence denotes This parallels the increased I kappa B alpha synthesis secondary to increased I kappa B alpha gene transcription, i.e., increased RNA and transcriptional activity of its promoter-enhancer.
S9 1100-1312 Sentence denotes Another protein with I kappa B function, p105, is also modified in HIV-infected cells: p105 and p50 steady-state protein levels are increased as a result of increased synthesis and proteolytic processing of p105.
S10 1313-1450 Sentence denotes Transcriptional activity of p105 is also increased in infected cells and is also mediated by NF-kappa B through a specific kappa B motif.
S11 1451-1669 Sentence denotes These results demonstrate the existence of a triple autoregulatory loop in monocytes and macrophages involving HIV, p105 and p50, and MAD3, with the end result of persistent NF-kappa B activation and viral persistence.
S12 1670-1840 Sentence denotes Furthermore, persistent HIV infection of monocytes and macrophages provides a useful model with which to study concomitant modifications of different I kappa B molecules.