| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-90 |
Sentence |
denotes |
Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus. |
| S2 |
91-186 |
Sentence |
denotes |
The hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg. |
| S3 |
187-275 |
Sentence |
denotes |
We have investigated whether this antigen is a target structure for human T-lymphocytes. |
| S4 |
276-524 |
Sentence |
denotes |
Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patients with acute hepatitis B virus infection (6 of 6) and chronic hepatitis B virus infection (6 of 17) but not in healthy individuals. |
| S5 |
525-609 |
Sentence |
denotes |
With HBxAg-specific synthetic polypeptides, several T-cell epitopes were identified. |
| S6 |
610-677 |
Sentence |
denotes |
Most were located in the carboxyterminal half of the HBxAg protein. |
| S7 |
678-857 |
Sentence |
denotes |
Five T-cell clones specific for a T-cell epitope located at the carboxyterminal region of HBxAg were established and found to belong to the CD2/CD4-positive, CD8-negative subtype. |
| S8 |
858-950 |
Sentence |
denotes |
These data establish for the first time HBxAg as an antigen in the cellular immune response. |
