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PubMed:10024618 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
S1 0-148 Sentence denotes Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations.
S2 149-381 Sentence denotes Daidzein and genistein glucuronides (DG and GG), major isoflavone metabolites, may be partly responsible for biological effects of isoflavones, such as estrogen receptor binding and natural killer cell (NK) activation or inhibition.
S3 382-465 Sentence denotes DG and GG were synthesized using 3-methylcholanthrene-induced rat liver microsomes.
S4 466-595 Sentence denotes The Km and Vmax for daidzein and genistein were 9.0 and 7.7 micromol/L, and 0.7 and 1.6 micromol/(mg protein. min), respectively.
S5 596-744 Sentence denotes The absence of ultraviolet absorbance maxima shifts in the presence of sodium acetate confirmed that the synthesized products were 7-O-glucuronides.
S6 745-804 Sentence denotes DG and GG were further purified by a Sephadex LH-20 column.
S7 805-920 Sentence denotes DG and GG competed with the binding of 17beta-(3H) estradiol to estrogen receptors of B6D2F1 mouse uterine cytosol.
S8 921-1168 Sentence denotes The concentrations required for 50% displacement of 17beta-(3H) estradiol (CB50) were: 17beta-estradiol, 1.34 nmol/L; diethylstilbestrol, 1.46 nmol/L; daidzein, 1.6 micromol/L; DG, 14.7 micromol/L; genistein, 0.154 micromol/L; GG, 7.27 micromol/L.
S9 1169-1345 Sentence denotes In human peripheral blood NK cells, genistein at <0.5 micromol/L and DG and GG at 0.1-10 micromol/L enhanced NK cell-mediated K562 cancer cell killing significantly (P < 0.05).
S10 1346-1428 Sentence denotes At > 0.5 micromol/L, genistein inhibited NK cytotoxicity significantly (P < 0.05).
S11 1429-1494 Sentence denotes The glucuronides only inhibited NK cytotoxicity at 50 micromol/L.
S12 1495-1620 Sentence denotes Isoflavones, and especially the isoflavone glucuronides, enhanced activation of NK cells by interleukin-2 (IL-2), additively.
S13 1621-1819 Sentence denotes At physiological concentrations, DG and GG were weakly estrogenic, and they activated human NK cells in nutritionally relevant concentrations in vitro, probably at a site different from IL-2 action.