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PMC:394351 / 36840-39645 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T10961 0-7 JJ denotes Biliary
T10962 8-17 NN denotes secretion
T10963 18-20 IN denotes of
T10964 21-25 NN denotes bile
T10965 26-31 NNS denotes salts
T10966 31-33 , denotes ,
T10967 33-39 NN denotes sterol
T10968 40-43 CC denotes and
T10969 44-57 NNS denotes phospholipids
T10970 58-60 IN denotes in
T10971 61-66 NN denotes Abcg8
T10973 66-67 HYPH denotes /
T10972 67-75 NN denotes sterolin
T10975 75-76 HYPH denotes -
T10976 76-77 CD denotes 2
T10974 78-87 JJ denotes deficient
T10977 88-92 NNS denotes mice
T10978 92-204 sentence denotes Sitosterolemic individuals have an impaired ability to secrete cholesterol and plant sterols into bile [40,41].
T10979 93-107 JJ denotes Sitosterolemic
T10980 108-119 NNS denotes individuals
T10981 120-124 VBP denotes have
T10982 125-127 DT denotes an
T10984 128-136 JJ denotes impaired
T10983 137-144 NN denotes ability
T10985 145-147 TO denotes to
T10986 148-155 VB denotes secrete
T10987 156-167 NN denotes cholesterol
T10988 168-171 CC denotes and
T10989 172-177 NN denotes plant
T10990 178-185 NNS denotes sterols
T10991 186-190 IN denotes into
T10992 191-195 NN denotes bile
T10993 196-197 -LRB- denotes [
T10995 197-199 CD denotes 40
T10996 199-200 , denotes ,
T10994 200-202 CD denotes 41
T10997 202-203 -RRB- denotes ]
T10998 203-204 . denotes .
T10999 204-282 sentence denotes We analyzed the knockout mice for any alterations in biliary sterol handling.
T11000 205-207 PRP denotes We
T11001 208-216 VBD denotes analyzed
T11002 217-220 DT denotes the
T11004 221-229 NN denotes knockout
T11003 230-234 NNS denotes mice
T11005 235-238 IN denotes for
T11006 239-242 DT denotes any
T11007 243-254 NNS denotes alterations
T11008 255-257 IN denotes in
T11009 258-265 JJ denotes biliary
T11010 266-272 NN denotes sterol
T11011 273-281 NN denotes handling
T11012 281-282 . denotes .
T11013 282-578 sentence denotes Analyses of the initial basal bile secretion showed that the sterol and phospholipid contents in Abcg8-/- mice were reduced as compared to wild-type mice, (Figure 8a,8b,8c, bile salt secretion not statistically significant, for sterol secretion P = 0.01 and for phospholipid secretion P = 0.03).
T11014 283-291 NNS denotes Analyses
T11016 292-294 IN denotes of
T11017 295-298 DT denotes the
T11019 299-306 JJ denotes initial
T11020 307-312 JJ denotes basal
T11021 313-317 NN denotes bile
T11018 318-327 NN denotes secretion
T11015 328-334 VBD denotes showed
T11022 335-339 IN denotes that
T11024 340-343 DT denotes the
T11026 344-350 NN denotes sterol
T11027 351-354 CC denotes and
T11028 355-367 NN denotes phospholipid
T11025 368-376 NNS denotes contents
T11029 377-379 IN denotes in
T11030 380-385 NN denotes Abcg8
T11032 385-386 SYM denotes -
T11033 386-387 HYPH denotes /
T11034 387-388 SYM denotes -
T11031 389-393 NNS denotes mice
T11035 394-398 VBD denotes were
T11023 399-406 VBN denotes reduced
T11036 407-409 IN denotes as
T11037 410-418 VBN denotes compared
T11038 419-421 IN denotes to
T11039 422-426 JJ denotes wild
T11041 426-427 HYPH denotes -
T11040 427-431 NN denotes type
T11042 432-436 NNS denotes mice
T11043 436-438 , denotes ,
T11044 438-439 -LRB- denotes (
T11046 439-445 NN denotes Figure
T11047 446-448 NN denotes 8a
T11048 448-449 , denotes ,
T11049 449-451 NN denotes 8b
T11050 451-452 , denotes ,
T11045 452-454 NN denotes 8c
T11051 454-456 , denotes ,
T11052 456-460 NN denotes bile
T11053 461-465 NN denotes salt
T11054 466-475 NN denotes secretion
T11056 476-479 RB denotes not
T11057 480-493 RB denotes statistically
T11055 494-505 JJ denotes significant
T11059 505-507 , denotes ,
T11060 507-510 IN denotes for
T11061 511-517 NN denotes sterol
T11062 518-527 NN denotes secretion
T11063 528-529 NN denotes P
T11064 530-531 SYM denotes =
T11058 532-536 CD denotes 0.01
T11065 537-540 CC denotes and
T11066 541-544 IN denotes for
T11068 545-557 NN denotes phospholipid
T11069 558-567 NN denotes secretion
T11070 568-569 NN denotes P
T11071 570-571 SYM denotes =
T11067 572-576 CD denotes 0.03
T11072 576-577 -RRB- denotes )
T11073 577-578 . denotes .
T11074 578-787 sentence denotes To investigate whether the defect in biliary sterol secretion could be (partly) restored by forced biliary sterol secretion, we infused mice with stepwise increasing doses of tauroursodeoxycholic acid (TUDC).
T11075 579-581 TO denotes To
T11076 582-593 VB denotes investigate
T11078 594-601 IN denotes whether
T11080 602-605 DT denotes the
T11081 606-612 NN denotes defect
T11082 613-615 IN denotes in
T11083 616-623 JJ denotes biliary
T11085 624-630 NN denotes sterol
T11084 631-640 NN denotes secretion
T11086 641-646 MD denotes could
T11087 647-649 VB denotes be
T11088 650-651 -LRB- denotes (
T11089 651-657 RB denotes partly
T11090 657-658 -RRB- denotes )
T11079 659-667 VBN denotes restored
T11091 668-670 IN denotes by
T11092 671-677 VBN denotes forced
T11094 678-685 JJ denotes biliary
T11095 686-692 NN denotes sterol
T11093 693-702 NN denotes secretion
T11096 702-704 , denotes ,
T11097 704-706 PRP denotes we
T11077 707-714 VBD denotes infused
T11098 715-719 NNS denotes mice
T11099 720-724 IN denotes with
T11100 725-733 JJ denotes stepwise
T11101 734-744 VBG denotes increasing
T11102 745-750 NNS denotes doses
T11103 751-753 IN denotes of
T11104 754-774 JJ denotes tauroursodeoxycholic
T11105 775-779 NN denotes acid
T11106 780-781 -LRB- denotes (
T11107 781-785 NN denotes TUDC
T11108 785-786 -RRB- denotes )
T11109 786-787 . denotes .
T11110 787-936 sentence denotes Mice were first depleted of their endogenous bile salt pools for 90 min and subsequently infused via the jugular vein with increasing doses of TUDC.
T11111 788-792 NNS denotes Mice
T11113 793-797 VBD denotes were
T11114 798-803 RB denotes first
T11112 804-812 VBN denotes depleted
T11115 813-815 IN denotes of
T11116 816-821 PRP$ denotes their
T11118 822-832 JJ denotes endogenous
T11119 833-837 NN denotes bile
T11120 838-842 NN denotes salt
T11117 843-848 NNS denotes pools
T11121 849-852 IN denotes for
T11122 853-855 CD denotes 90
T11123 856-859 NN denotes min
T11124 860-863 CC denotes and
T11125 864-876 RB denotes subsequently
T11126 877-884 VBN denotes infused
T11127 885-888 IN denotes via
T11128 889-892 DT denotes the
T11130 893-900 JJ denotes jugular
T11129 901-905 NN denotes vein
T11131 906-910 IN denotes with
T11132 911-921 VBG denotes increasing
T11133 922-927 NNS denotes doses
T11134 928-930 IN denotes of
T11135 931-935 NN denotes TUDC
T11136 935-936 . denotes .
T11137 936-1096 sentence denotes As shown in Figure 8d, bile salt secretion was no different between the different genotypes during the depletion or the TUDC infusion phases of the experiment.
T11138 937-939 IN denotes As
T11139 940-945 VBN denotes shown
T11141 946-948 IN denotes in
T11142 949-955 NN denotes Figure
T11143 956-958 NN denotes 8d
T11144 958-960 , denotes ,
T11145 960-964 NN denotes bile
T11146 965-969 NN denotes salt
T11147 970-979 NN denotes secretion
T11140 980-983 VBD denotes was
T11148 984-986 RB denotes no
T11149 987-996 JJ denotes different
T11150 997-1004 IN denotes between
T11151 1005-1008 DT denotes the
T11153 1009-1018 JJ denotes different
T11152 1019-1028 NNS denotes genotypes
T11154 1029-1035 IN denotes during
T11155 1036-1039 DT denotes the
T11156 1040-1049 NN denotes depletion
T11157 1050-1052 CC denotes or
T11158 1053-1056 DT denotes the
T11160 1057-1061 NN denotes TUDC
T11159 1062-1070 NN denotes infusion
T11161 1071-1077 NNS denotes phases
T11162 1078-1080 IN denotes of
T11163 1081-1084 DT denotes the
T11164 1085-1095 NN denotes experiment
T11165 1095-1096 . denotes .
T11166 1096-1180 sentence denotes However, a different pattern emerged for the secretion of phospholipid (Figure 8f).
T11167 1097-1104 RB denotes However
T11169 1104-1106 , denotes ,
T11170 1106-1107 DT denotes a
T11172 1108-1117 JJ denotes different
T11171 1118-1125 NN denotes pattern
T11168 1126-1133 VBD denotes emerged
T11173 1134-1137 IN denotes for
T11174 1138-1141 DT denotes the
T11175 1142-1151 NN denotes secretion
T11176 1152-1154 IN denotes of
T11177 1155-1167 NN denotes phospholipid
T11178 1168-1169 -LRB- denotes (
T11180 1169-1175 NN denotes Figure
T11179 1176-1178 NN denotes 8f
T11181 1178-1179 -RRB- denotes )
T11182 1179-1180 . denotes .
T11183 1180-1356 sentence denotes There was no difference between wild-type and heterozygous mice, but knockout mice showed a trend of lower phospholipid secretion during both the depletion and infusion phase.
T11184 1181-1186 EX denotes There
T11185 1187-1190 VBD denotes was
T11186 1191-1193 DT denotes no
T11187 1194-1204 NN denotes difference
T11188 1205-1212 IN denotes between
T11189 1213-1217 JJ denotes wild
T11191 1217-1218 HYPH denotes -
T11190 1218-1222 NN denotes type
T11193 1223-1226 CC denotes and
T11194 1227-1239 JJ denotes heterozygous
T11192 1240-1244 NNS denotes mice
T11195 1244-1246 , denotes ,
T11196 1246-1249 CC denotes but
T11197 1250-1258 NN denotes knockout
T11198 1259-1263 NNS denotes mice
T11199 1264-1270 VBD denotes showed
T11200 1271-1272 DT denotes a
T11201 1273-1278 NN denotes trend
T11202 1279-1281 IN denotes of
T11203 1282-1287 JJR denotes lower
T11205 1288-1300 NN denotes phospholipid
T11204 1301-1310 NN denotes secretion
T11206 1311-1317 IN denotes during
T11207 1318-1322 CC denotes both
T11209 1323-1326 DT denotes the
T11210 1327-1336 NN denotes depletion
T11211 1337-1340 CC denotes and
T11212 1341-1349 NN denotes infusion
T11208 1350-1355 NN denotes phase
T11213 1355-1356 . denotes .
T11214 1356-1580 sentence denotes Even more dramatic was the effect on biliary sterol secretion although the sterol contents were determined enzymatically and no distinction is made as to whether this is sitosterol or cholesterol (Figure 8e, but see below).
T11215 1357-1361 RB denotes Even
T11216 1362-1366 RBR denotes more
T11217 1367-1375 JJ denotes dramatic
T11218 1376-1379 VBD denotes was
T11219 1380-1383 DT denotes the
T11220 1384-1390 NN denotes effect
T11221 1391-1393 IN denotes on
T11222 1394-1401 JJ denotes biliary
T11223 1402-1408 NN denotes sterol
T11224 1409-1418 NN denotes secretion
T11225 1419-1427 IN denotes although
T11227 1428-1431 DT denotes the
T11229 1432-1438 NN denotes sterol
T11228 1439-1447 NNS denotes contents
T11230 1448-1452 VBD denotes were
T11226 1453-1463 VBN denotes determined
T11231 1464-1477 RB denotes enzymatically
T11232 1478-1481 CC denotes and
T11233 1482-1484 DT denotes no
T11234 1485-1496 NN denotes distinction
T11236 1497-1499 VBZ denotes is
T11235 1500-1504 VBN denotes made
T11237 1505-1507 IN denotes as
T11238 1508-1510 IN denotes to
T11239 1511-1518 IN denotes whether
T11241 1519-1523 DT denotes this
T11240 1524-1526 VBZ denotes is
T11242 1527-1537 NN denotes sitosterol
T11243 1538-1540 CC denotes or
T11244 1541-1552 NN denotes cholesterol
T11245 1553-1554 -LRB- denotes (
T11247 1554-1560 NN denotes Figure
T11246 1561-1563 NN denotes 8e
T11248 1563-1565 , denotes ,
T11249 1565-1568 CC denotes but
T11250 1569-1572 VB denotes see
T11251 1573-1578 RB denotes below
T11252 1578-1579 -RRB- denotes )
T11253 1579-1580 . denotes .
T11254 1580-1708 sentence denotes In the knockout mice, almost no stimulated sterol secretion was noted, with an intermediate phenotype in the heterozygous mice.
T11255 1581-1583 IN denotes In
T11257 1584-1587 DT denotes the
T11259 1588-1596 NN denotes knockout
T11258 1597-1601 NNS denotes mice
T11260 1601-1603 , denotes ,
T11261 1603-1609 RB denotes almost
T11263 1610-1612 DT denotes no
T11264 1613-1623 VBN denotes stimulated
T11265 1624-1630 NN denotes sterol
T11262 1631-1640 NN denotes secretion
T11266 1641-1644 VBD denotes was
T11256 1645-1650 VBN denotes noted
T11267 1650-1652 , denotes ,
T11268 1652-1656 IN denotes with
T11269 1657-1659 DT denotes an
T11271 1660-1672 JJ denotes intermediate
T11270 1673-1682 NN denotes phenotype
T11272 1683-1685 IN denotes in
T11273 1686-1689 DT denotes the
T11275 1690-1702 JJ denotes heterozygous
T11274 1703-1707 NNS denotes mice
T11276 1707-1708 . denotes .
T11277 1708-1910 sentence denotes In the heterozygous mice, sterol secretion increased to reach a maximal level of about 50% of the wild type suggesting that Abcg8/sterolin-2 is a rate-limiting step for biliary 'cholesterol' secretion.
T11278 1709-1711 IN denotes In
T11280 1712-1715 DT denotes the
T11282 1716-1728 JJ denotes heterozygous
T11281 1729-1733 NNS denotes mice
T11283 1733-1735 , denotes ,
T11284 1735-1741 NN denotes sterol
T11285 1742-1751 NN denotes secretion
T11279 1752-1761 VBD denotes increased
T11286 1762-1764 TO denotes to
T11287 1765-1770 VB denotes reach
T11288 1771-1772 DT denotes a
T11290 1773-1780 JJ denotes maximal
T11289 1781-1786 NN denotes level
T11291 1787-1789 IN denotes of
T11292 1790-1795 IN denotes about
T11293 1796-1798 CD denotes 50
T11294 1798-1799 NN denotes %
T11295 1800-1802 IN denotes of
T11296 1803-1806 DT denotes the
T11298 1807-1811 JJ denotes wild
T11297 1812-1816 NN denotes type
T11299 1817-1827 VBG denotes suggesting
T11300 1828-1832 IN denotes that
T11302 1833-1838 NN denotes Abcg8
T11304 1838-1839 HYPH denotes /
T11303 1839-1847 NN denotes sterolin
T11305 1847-1848 HYPH denotes -
T11306 1848-1849 CD denotes 2
T11301 1850-1852 VBZ denotes is
T11307 1853-1854 DT denotes a
T11309 1855-1859 NN denotes rate
T11311 1859-1860 HYPH denotes -
T11310 1860-1868 VBG denotes limiting
T11308 1869-1873 NN denotes step
T11312 1874-1877 IN denotes for
T11313 1878-1885 JJ denotes biliary
T11315 1886-1887 `` denotes '
T11316 1887-1898 NN denotes cholesterol
T11317 1898-1899 '' denotes '
T11314 1900-1909 NN denotes secretion
T11318 1909-1910 . denotes .
T11319 1910-2052 sentence denotes In the knockout mice, sterol secretion remained at a constant level during the depletion phase and increased minimally upon infusion of TUDC.
T11320 1911-1913 IN denotes In
T11322 1914-1917 DT denotes the
T11324 1918-1926 NN denotes knockout
T11323 1927-1931 NNS denotes mice
T11325 1931-1933 , denotes ,
T11326 1933-1939 NN denotes sterol
T11327 1940-1949 NN denotes secretion
T11321 1950-1958 VBD denotes remained
T11328 1959-1961 IN denotes at
T11329 1962-1963 DT denotes a
T11331 1964-1972 JJ denotes constant
T11330 1973-1978 NN denotes level
T11332 1979-1985 IN denotes during
T11333 1986-1989 DT denotes the
T11335 1990-1999 NN denotes depletion
T11334 2000-2005 NN denotes phase
T11336 2006-2009 CC denotes and
T11337 2010-2019 VBN denotes increased
T11338 2020-2029 RB denotes minimally
T11339 2030-2034 IN denotes upon
T11340 2035-2043 NN denotes infusion
T11341 2044-2046 IN denotes of
T11342 2047-2051 NN denotes TUDC
T11343 2051-2052 . denotes .
T11344 2052-2176 sentence denotes Since the Abcg8-/- mice still secreted some sterols we were interested in which biliary sterol species were being secreted.
T11345 2053-2058 IN denotes Since
T11347 2059-2062 DT denotes the
T11349 2063-2068 NN denotes Abcg8
T11350 2068-2069 SYM denotes -
T11351 2069-2070 HYPH denotes /
T11352 2070-2071 SYM denotes -
T11348 2072-2076 NNS denotes mice
T11353 2077-2082 RB denotes still
T11346 2083-2091 VBD denotes secreted
T11355 2092-2096 DT denotes some
T11356 2097-2104 NNS denotes sterols
T11357 2105-2107 PRP denotes we
T11354 2108-2112 VBD denotes were
T11358 2113-2123 JJ denotes interested
T11359 2124-2126 IN denotes in
T11360 2127-2132 WDT denotes which
T11362 2133-2140 JJ denotes biliary
T11363 2141-2147 NN denotes sterol
T11361 2148-2155 NNS denotes species
T11365 2156-2160 VBD denotes were
T11366 2161-2166 VBG denotes being
T11364 2167-2175 VBN denotes secreted
T11367 2175-2176 . denotes .
T11368 2176-2270 sentence denotes Therefore bile was collected from mice during a constant infusion of TUDC and analyzed by GC.
T11369 2177-2186 RB denotes Therefore
T11371 2187-2191 NN denotes bile
T11372 2192-2195 VBD denotes was
T11370 2196-2205 VBN denotes collected
T11373 2206-2210 IN denotes from
T11374 2211-2215 NNS denotes mice
T11375 2216-2222 IN denotes during
T11376 2223-2224 DT denotes a
T11378 2225-2233 JJ denotes constant
T11377 2234-2242 NN denotes infusion
T11379 2243-2245 IN denotes of
T11380 2246-2250 NN denotes TUDC
T11381 2251-2254 CC denotes and
T11382 2255-2263 VBN denotes analyzed
T11383 2264-2266 IN denotes by
T11384 2267-2269 NN denotes GC
T11385 2269-2270 . denotes .
T11386 2270-2426 sentence denotes Mice were first depleted of their endogenous bile acid pools for 30 minutes then infused with a continuous dose of TUDC (1,200 nmol/min/100 g body weight).
T11387 2271-2275 NNS denotes Mice
T11389 2276-2280 VBD denotes were
T11390 2281-2286 RB denotes first
T11388 2287-2295 VBN denotes depleted
T11391 2296-2298 IN denotes of
T11392 2299-2304 PRP$ denotes their
T11394 2305-2315 JJ denotes endogenous
T11395 2316-2320 NN denotes bile
T11396 2321-2325 NN denotes acid
T11393 2326-2331 NNS denotes pools
T11397 2332-2335 IN denotes for
T11398 2336-2338 CD denotes 30
T11399 2339-2346 NNS denotes minutes
T11400 2347-2351 RB denotes then
T11401 2352-2359 VBN denotes infused
T11402 2360-2364 IN denotes with
T11403 2365-2366 DT denotes a
T11405 2367-2377 JJ denotes continuous
T11404 2378-2382 NN denotes dose
T11406 2383-2385 IN denotes of
T11407 2386-2390 NN denotes TUDC
T11408 2391-2392 -LRB- denotes (
T11410 2392-2397 CD denotes 1,200
T11409 2398-2402 NN denotes nmol
T11411 2402-2403 SYM denotes /
T11412 2403-2406 NN denotes min
T11413 2406-2407 SYM denotes /
T11415 2407-2410 NN denotes 100
T11416 2411-2412 NN denotes g
T11417 2413-2417 NN denotes body
T11414 2418-2424 NN denotes weight
T11418 2424-2425 -RRB- denotes )
T11419 2425-2426 . denotes .
T11420 2426-2620 sentence denotes The knockout mice showed a significantly diminished ability to secrete cholesterol, yet still maintained the ability to secrete sitosterol and campesterol compared to wild-type mice (Figure 9).
T11421 2427-2430 DT denotes The
T11423 2431-2439 NN denotes knockout
T11422 2440-2444 NNS denotes mice
T11424 2445-2451 VBD denotes showed
T11425 2452-2453 DT denotes a
T11427 2454-2467 RB denotes significantly
T11428 2468-2478 VBN denotes diminished
T11426 2479-2486 NN denotes ability
T11429 2487-2489 TO denotes to
T11430 2490-2497 VB denotes secrete
T11431 2498-2509 NN denotes cholesterol
T11432 2509-2511 , denotes ,
T11433 2511-2514 CC denotes yet
T11434 2515-2520 RB denotes still
T11435 2521-2531 VBD denotes maintained
T11436 2532-2535 DT denotes the
T11437 2536-2543 NN denotes ability
T11438 2544-2546 TO denotes to
T11439 2547-2554 VB denotes secrete
T11440 2555-2565 NN denotes sitosterol
T11441 2566-2569 CC denotes and
T11442 2570-2581 NN denotes campesterol
T11443 2582-2590 VBN denotes compared
T11444 2591-2593 IN denotes to
T11445 2594-2598 JJ denotes wild
T11447 2598-2599 HYPH denotes -
T11446 2599-2603 NN denotes type
T11448 2604-2608 NNS denotes mice
T11449 2609-2610 -LRB- denotes (
T11450 2610-2616 NN denotes Figure
T11451 2617-2618 CD denotes 9
T11452 2618-2619 -RRB- denotes )
T11453 2619-2620 . denotes .
T11454 2620-2805 sentence denotes Surprisingly, the Abcg8+/- mice tended to show an increased ability to secrete all sterols above the levels seen in the wild-type mice, although this was not statistically significant.
T11455 2621-2633 RB denotes Surprisingly
T11457 2633-2635 , denotes ,
T11458 2635-2638 DT denotes the
T11460 2639-2644 NN denotes Abcg8
T11461 2644-2645 SYM denotes +
T11462 2645-2646 HYPH denotes /
T11463 2646-2647 SYM denotes -
T11459 2648-2652 NNS denotes mice
T11456 2653-2659 VBD denotes tended
T11464 2660-2662 TO denotes to
T11465 2663-2667 VB denotes show
T11466 2668-2670 DT denotes an
T11468 2671-2680 VBN denotes increased
T11467 2681-2688 NN denotes ability
T11469 2689-2691 TO denotes to
T11470 2692-2699 VB denotes secrete
T11471 2700-2703 DT denotes all
T11472 2704-2711 NNS denotes sterols
T11473 2712-2717 IN denotes above
T11474 2718-2721 DT denotes the
T11475 2722-2728 NNS denotes levels
T11476 2729-2733 VBN denotes seen
T11477 2734-2736 IN denotes in
T11478 2737-2740 DT denotes the
T11480 2741-2745 JJ denotes wild
T11482 2745-2746 HYPH denotes -
T11481 2746-2750 NN denotes type
T11479 2751-2755 NNS denotes mice
T11483 2755-2757 , denotes ,
T11484 2757-2765 IN denotes although
T11486 2766-2770 DT denotes this
T11485 2771-2774 VBD denotes was
T11487 2775-2778 RB denotes not
T11488 2779-2792 RB denotes statistically
T11489 2793-2804 JJ denotes significant
T11490 2804-2805 . denotes .
R7050 T10961 T10962 amod Biliary,secretion
R7051 T10963 T10962 prep of,secretion
R7052 T10964 T10965 compound bile,salts
R7053 T10965 T10963 pobj salts,of
R7054 T10966 T10965 punct ", ",salts
R7055 T10967 T10965 conj sterol,salts
R7056 T10968 T10967 cc and,sterol
R7057 T10969 T10967 conj phospholipids,sterol
R7058 T10970 T10962 prep in,secretion
R7059 T10971 T10972 compound Abcg8,sterolin
R7060 T10972 T10974 npadvmod sterolin,deficient
R7061 T10973 T10972 punct /,sterolin
R7062 T10974 T10977 amod deficient,mice
R7063 T10975 T10972 punct -,sterolin
R7064 T10976 T10972 nummod 2,sterolin
R7065 T10977 T10970 pobj mice,in
R7066 T10979 T10980 amod Sitosterolemic,individuals
R7067 T10980 T10981 nsubj individuals,have
R7068 T10982 T10983 det an,ability
R7069 T10983 T10981 dobj ability,have
R7070 T10984 T10983 amod impaired,ability
R7071 T10985 T10986 aux to,secrete
R7072 T10986 T10983 acl secrete,ability
R7073 T10987 T10986 dobj cholesterol,secrete
R7074 T10988 T10987 cc and,cholesterol
R7075 T10989 T10990 compound plant,sterols
R7076 T10990 T10987 conj sterols,cholesterol
R7077 T10991 T10986 prep into,secrete
R7078 T10992 T10991 pobj bile,into
R7079 T10993 T10994 punct [,41
R7080 T10994 T10981 parataxis 41,have
R7081 T10995 T10994 nummod 40,41
R7082 T10996 T10994 punct ",",41
R7083 T10997 T10994 punct ],41
R7084 T10998 T10981 punct .,have
R7085 T11000 T11001 nsubj We,analyzed
R7086 T11002 T11003 det the,mice
R7087 T11003 T11001 dobj mice,analyzed
R7088 T11004 T11003 compound knockout,mice
R7089 T11005 T11001 prep for,analyzed
R7090 T11006 T11007 det any,alterations
R7091 T11007 T11005 pobj alterations,for
R7092 T11008 T11007 prep in,alterations
R7093 T11009 T11010 amod biliary,sterol
R7094 T11010 T11011 compound sterol,handling
R7095 T11011 T11008 pobj handling,in
R7096 T11012 T11001 punct .,analyzed
R7097 T11014 T11015 nsubj Analyses,showed
R7098 T11016 T11014 prep of,Analyses
R7099 T11017 T11018 det the,secretion
R7100 T11018 T11016 pobj secretion,of
R7101 T11019 T11018 amod initial,secretion
R7102 T11020 T11018 amod basal,secretion
R7103 T11021 T11018 compound bile,secretion
R7104 T11022 T11023 mark that,reduced
R7105 T11023 T11015 ccomp reduced,showed
R7106 T11024 T11025 det the,contents
R7107 T11025 T11023 nsubjpass contents,reduced
R7108 T11026 T11025 nmod sterol,contents
R7109 T11027 T11026 cc and,sterol
R7110 T11028 T11026 conj phospholipid,sterol
R7111 T11029 T11025 prep in,contents
R7112 T11030 T11031 nmod Abcg8,mice
R7113 T11031 T11029 pobj mice,in
R7114 T11032 T11030 punct -,Abcg8
R7115 T11033 T11030 punct /,Abcg8
R7116 T11034 T11030 punct -,Abcg8
R7117 T11035 T11023 auxpass were,reduced
R7118 T11036 T11037 mark as,compared
R7119 T11037 T11023 advcl compared,reduced
R7120 T11038 T11037 prep to,compared
R7121 T11039 T11040 amod wild,type
R7122 T11040 T11042 compound type,mice
R7123 T11041 T11040 punct -,type
R7124 T11042 T11038 pobj mice,to
R7125 T11043 T11015 punct ", ",showed
R7126 T11044 T11045 punct (,8c
R7127 T11045 T11015 parataxis 8c,showed
R7128 T11046 T11045 nmod Figure,8c
R7129 T11047 T11045 nmod 8a,8c
R7130 T11048 T11045 punct ",",8c
R7131 T11049 T11045 nmod 8b,8c
R7132 T11050 T11045 punct ",",8c
R7133 T11051 T11045 punct ", ",8c
R7134 T11052 T11053 compound bile,salt
R7135 T11053 T11054 compound salt,secretion
R7136 T11054 T11055 nsubj secretion,significant
R7137 T11055 T11058 amod significant,0.01
R7138 T11056 T11055 neg not,significant
R7139 T11057 T11055 advmod statistically,significant
R7140 T11058 T11045 ccomp 0.01,8c
R7141 T11059 T11058 punct ", ",0.01
R7142 T11060 T11058 prep for,0.01
R7143 T11061 T11062 compound sterol,secretion
R7144 T11062 T11060 pobj secretion,for
R7145 T11063 T11058 nsubj P,0.01
R7146 T11064 T11058 punct =,0.01
R7147 T11065 T11058 cc and,0.01
R7148 T11066 T11067 prep for,0.03
R7149 T11067 T11058 conj 0.03,0.01
R7150 T11068 T11069 compound phospholipid,secretion
R7151 T11069 T11066 pobj secretion,for
R7152 T11070 T11067 nsubj P,0.03
R7153 T11071 T11067 punct =,0.03
R7154 T11072 T11045 punct ),8c
R7155 T11073 T11015 punct .,showed
R7156 T11075 T11076 aux To,investigate
R7157 T11076 T11077 advcl investigate,infused
R7158 T11078 T11079 mark whether,restored
R7159 T11079 T11076 ccomp restored,investigate
R7160 T11080 T11081 det the,defect
R7161 T11081 T11079 nsubjpass defect,restored
R7162 T11082 T11081 prep in,defect
R7163 T11083 T11084 amod biliary,secretion
R7164 T11084 T11082 pobj secretion,in
R7165 T11085 T11084 compound sterol,secretion
R7166 T11086 T11079 aux could,restored
R7167 T11087 T11079 auxpass be,restored
R7168 T11088 T11079 punct (,restored
R7169 T11089 T11079 advmod partly,restored
R7170 T11090 T11079 punct ),restored
R7171 T11091 T11079 prep by,restored
R7172 T11092 T11093 amod forced,secretion
R7173 T11093 T11091 pobj secretion,by
R7174 T11094 T11095 amod biliary,sterol
R7175 T11095 T11093 compound sterol,secretion
R7176 T11096 T11077 punct ", ",infused
R7177 T11097 T11077 nsubj we,infused
R7178 T11098 T11077 dobj mice,infused
R7179 T11099 T11077 prep with,infused
R7180 T11100 T11101 amod stepwise,increasing
R7181 T11101 T11102 amod increasing,doses
R7182 T11102 T11099 pobj doses,with
R7183 T11103 T11102 prep of,doses
R7184 T11104 T11105 amod tauroursodeoxycholic,acid
R7185 T11105 T11103 pobj acid,of
R7186 T11106 T11105 punct (,acid
R7187 T11107 T11105 appos TUDC,acid
R7188 T11108 T11077 punct ),infused
R7189 T11109 T11077 punct .,infused
R7190 T11111 T11112 nsubjpass Mice,depleted
R7191 T11113 T11112 auxpass were,depleted
R7192 T11114 T11112 advmod first,depleted
R7193 T11115 T11112 prep of,depleted
R7194 T11116 T11117 poss their,pools
R7195 T11117 T11115 pobj pools,of
R7196 T11118 T11117 amod endogenous,pools
R7197 T11119 T11120 compound bile,salt
R7198 T11120 T11117 compound salt,pools
R7199 T11121 T11112 prep for,depleted
R7200 T11122 T11123 nummod 90,min
R7201 T11123 T11121 pobj min,for
R7202 T11124 T11112 cc and,depleted
R7203 T11125 T11126 advmod subsequently,infused
R7204 T11126 T11112 conj infused,depleted
R7205 T11127 T11126 prep via,infused
R7206 T11128 T11129 det the,vein
R7207 T11129 T11127 pobj vein,via
R7208 T11130 T11129 amod jugular,vein
R7209 T11131 T11126 prep with,infused
R7210 T11132 T11133 amod increasing,doses
R7211 T11133 T11131 pobj doses,with
R7212 T11134 T11133 prep of,doses
R7213 T11135 T11134 pobj TUDC,of
R7214 T11136 T11112 punct .,depleted
R7215 T11138 T11139 mark As,shown
R7216 T11139 T11140 advcl shown,was
R7217 T11141 T11139 prep in,shown
R7218 T11142 T11143 compound Figure,8d
R7219 T11143 T11141 pobj 8d,in
R7220 T11144 T11140 punct ", ",was
R7221 T11145 T11146 compound bile,salt
R7222 T11146 T11147 compound salt,secretion
R7223 T11147 T11140 nsubj secretion,was
R7224 T11148 T11149 neg no,different
R7225 T11149 T11140 acomp different,was
R7226 T11150 T11140 prep between,was
R7227 T11151 T11152 det the,genotypes
R7228 T11152 T11150 pobj genotypes,between
R7229 T11153 T11152 amod different,genotypes
R7230 T11154 T11140 prep during,was
R7231 T11155 T11156 det the,depletion
R7232 T11156 T11154 pobj depletion,during
R7233 T11157 T11156 cc or,depletion
R7234 T11158 T11159 det the,infusion
R7235 T11159 T11161 compound infusion,phases
R7236 T11160 T11159 compound TUDC,infusion
R7237 T11161 T11156 conj phases,depletion
R7238 T11162 T11156 prep of,depletion
R7239 T11163 T11164 det the,experiment
R7240 T11164 T11162 pobj experiment,of
R7241 T11165 T11140 punct .,was
R7242 T11167 T11168 advmod However,emerged
R7243 T11169 T11168 punct ", ",emerged
R7244 T11170 T11171 det a,pattern
R7245 T11171 T11168 nsubj pattern,emerged
R7246 T11172 T11171 amod different,pattern
R7247 T11173 T11168 prep for,emerged
R7248 T11174 T11175 det the,secretion
R7249 T11175 T11173 pobj secretion,for
R7250 T11176 T11175 prep of,secretion
R7251 T11177 T11176 pobj phospholipid,of
R7252 T11178 T11179 punct (,8f
R7253 T11179 T11168 parataxis 8f,emerged
R7254 T11180 T11179 compound Figure,8f
R7255 T11181 T11179 punct ),8f
R7256 T11182 T11168 punct .,emerged
R7257 T11184 T11185 expl There,was
R7258 T11186 T11187 det no,difference
R7259 T11187 T11185 attr difference,was
R7260 T11188 T11187 prep between,difference
R7261 T11189 T11190 amod wild,type
R7262 T11190 T11192 nmod type,mice
R7263 T11191 T11190 punct -,type
R7264 T11192 T11188 pobj mice,between
R7265 T11193 T11190 cc and,type
R7266 T11194 T11190 conj heterozygous,type
R7267 T11195 T11185 punct ", ",was
R7268 T11196 T11185 cc but,was
R7269 T11197 T11198 compound knockout,mice
R7270 T11198 T11199 nsubj mice,showed
R7271 T11199 T11185 conj showed,was
R7272 T11200 T11201 det a,trend
R7273 T11201 T11199 dobj trend,showed
R7274 T11202 T11201 prep of,trend
R7275 T11203 T11204 amod lower,secretion
R7276 T11204 T11202 pobj secretion,of
R7277 T11205 T11204 compound phospholipid,secretion
R7278 T11206 T11199 prep during,showed
R7279 T11207 T11208 preconj both,phase
R7280 T11208 T11206 pobj phase,during
R7281 T11209 T11208 det the,phase
R7282 T11210 T11208 nmod depletion,phase
R7283 T11211 T11210 cc and,depletion
R7284 T11212 T11210 conj infusion,depletion
R7285 T11213 T11199 punct .,showed
R7286 T11215 T11216 advmod Even,more
R7287 T11216 T11217 advmod more,dramatic
R7288 T11217 T11218 acomp dramatic,was
R7289 T11219 T11220 det the,effect
R7290 T11220 T11218 nsubj effect,was
R7291 T11221 T11220 prep on,effect
R7292 T11222 T11223 amod biliary,sterol
R7293 T11223 T11224 compound sterol,secretion
R7294 T11224 T11221 pobj secretion,on
R7295 T11225 T11226 mark although,determined
R7296 T11226 T11218 advcl determined,was
R7297 T11227 T11228 det the,contents
R7298 T11228 T11226 nsubjpass contents,determined
R7299 T11229 T11228 compound sterol,contents
R7300 T11230 T11226 auxpass were,determined
R7301 T11231 T11226 advmod enzymatically,determined
R7302 T11232 T11226 cc and,determined
R7303 T11233 T11234 det no,distinction
R7304 T11234 T11235 nsubjpass distinction,made
R7305 T11235 T11226 conj made,determined
R7306 T11236 T11235 auxpass is,made
R7307 T11237 T11235 prep as,made
R7308 T11238 T11237 prep to,as
R7309 T11239 T11240 mark whether,is
R7310 T11240 T11238 pcomp is,to
R7311 T11241 T11240 nsubj this,is
R7312 T11242 T11240 attr sitosterol,is
R7313 T11243 T11242 cc or,sitosterol
R7314 T11244 T11242 conj cholesterol,sitosterol
R7315 T11245 T11246 punct (,8e
R7316 T11246 T11218 parataxis 8e,was
R7317 T11247 T11246 compound Figure,8e
R7318 T11248 T11246 punct ", ",8e
R7319 T11249 T11246 cc but,8e
R7320 T11250 T11246 conj see,8e
R7321 T11251 T11250 advmod below,see
R7322 T11252 T11246 punct ),8e
R7323 T11253 T11218 punct .,was
R7324 T11255 T11256 prep In,noted
R7325 T11257 T11258 det the,mice
R7326 T11258 T11255 pobj mice,In
R7327 T11259 T11258 compound knockout,mice
R7328 T11260 T11256 punct ", ",noted
R7329 T11261 T11262 advmod almost,secretion
R7330 T11262 T11256 nsubjpass secretion,noted
R7331 T11263 T11262 det no,secretion
R7332 T11264 T11262 amod stimulated,secretion
R7333 T11265 T11262 compound sterol,secretion
R7334 T11266 T11256 auxpass was,noted
R7335 T11267 T11256 punct ", ",noted
R7336 T11268 T11256 prep with,noted
R7337 T11269 T11270 det an,phenotype
R7338 T11270 T11268 pobj phenotype,with
R7339 T11271 T11270 amod intermediate,phenotype
R7340 T11272 T11270 prep in,phenotype
R7341 T11273 T11274 det the,mice
R7342 T11274 T11272 pobj mice,in
R7343 T11275 T11274 amod heterozygous,mice
R7344 T11276 T11256 punct .,noted
R7345 T11278 T11279 prep In,increased
R7346 T11280 T11281 det the,mice
R7347 T11281 T11278 pobj mice,In
R7348 T11282 T11281 amod heterozygous,mice
R7349 T11283 T11279 punct ", ",increased
R7350 T11284 T11285 compound sterol,secretion
R7351 T11285 T11279 nsubj secretion,increased
R7352 T11286 T11287 aux to,reach
R7353 T11287 T11279 advcl reach,increased
R7354 T11288 T11289 det a,level
R7355 T11289 T11287 dobj level,reach
R7356 T11290 T11289 amod maximal,level
R7357 T11291 T11289 prep of,level
R7358 T11292 T11293 quantmod about,50
R7359 T11293 T11294 nummod 50,%
R7360 T11294 T11291 pobj %,of
R7361 T11295 T11294 prep of,%
R7362 T11296 T11297 det the,type
R7363 T11297 T11295 pobj type,of
R7364 T11298 T11297 amod wild,type
R7365 T11299 T11279 advcl suggesting,increased
R7366 T11300 T11301 mark that,is
R7367 T11301 T11299 ccomp is,suggesting
R7368 T11302 T11303 compound Abcg8,sterolin
R7369 T11303 T11301 nsubj sterolin,is
R7370 T11304 T11303 punct /,sterolin
R7371 T11305 T11303 punct -,sterolin
R7372 T11306 T11303 nummod 2,sterolin
R7373 T11307 T11308 det a,step
R7374 T11308 T11301 attr step,is
R7375 T11309 T11310 npadvmod rate,limiting
R7376 T11310 T11308 amod limiting,step
R7377 T11311 T11310 punct -,limiting
R7378 T11312 T11308 prep for,step
R7379 T11313 T11314 amod biliary,secretion
R7380 T11314 T11312 pobj secretion,for
R7381 T11315 T11314 punct ',secretion
R7382 T11316 T11314 nmod cholesterol,secretion
R7383 T11317 T11314 punct ',secretion
R7384 T11318 T11279 punct .,increased
R7385 T11320 T11321 prep In,remained
R7386 T11322 T11323 det the,mice
R7387 T11323 T11320 pobj mice,In
R7388 T11324 T11323 compound knockout,mice
R7389 T11325 T11321 punct ", ",remained
R7390 T11326 T11327 compound sterol,secretion
R7391 T11327 T11321 nsubj secretion,remained
R7392 T11328 T11321 oprd at,remained
R7393 T11329 T11330 det a,level
R7394 T11330 T11328 pobj level,at
R7395 T11331 T11330 amod constant,level
R7396 T11332 T11321 prep during,remained
R7397 T11333 T11334 det the,phase
R7398 T11334 T11332 pobj phase,during
R7399 T11335 T11334 compound depletion,phase
R7400 T11336 T11321 cc and,remained
R7401 T11337 T11321 conj increased,remained
R7402 T11338 T11337 advmod minimally,increased
R7403 T11339 T11337 prep upon,increased
R7404 T11340 T11339 pobj infusion,upon
R7405 T11341 T11340 prep of,infusion
R7406 T11342 T11341 pobj TUDC,of
R7407 T11343 T11321 punct .,remained
R7408 T11345 T11346 mark Since,secreted
R7409 T11346 T11354 advcl secreted,were
R7410 T11347 T11348 det the,mice
R7411 T11348 T11346 nsubj mice,secreted
R7412 T11349 T11348 nmod Abcg8,mice
R7413 T11350 T11349 punct -,Abcg8
R7414 T11351 T11349 punct /,Abcg8
R7415 T11352 T11349 punct -,Abcg8
R7416 T11353 T11346 advmod still,secreted
R7417 T11355 T11356 det some,sterols
R7418 T11356 T11346 dobj sterols,secreted
R7419 T11357 T11354 nsubj we,were
R7420 T11358 T11354 acomp interested,were
R7421 T11359 T11358 prep in,interested
R7422 T11360 T11361 det which,species
R7423 T11361 T11364 dep species,secreted
R7424 T11362 T11363 amod biliary,sterol
R7425 T11363 T11361 compound sterol,species
R7426 T11364 T11359 pcomp secreted,in
R7427 T11365 T11364 aux were,secreted
R7428 T11366 T11364 auxpass being,secreted
R7429 T11367 T11354 punct .,were
R7430 T11369 T11370 advmod Therefore,collected
R7431 T11371 T11370 nsubjpass bile,collected
R7432 T11372 T11370 auxpass was,collected
R7433 T11373 T11370 prep from,collected
R7434 T11374 T11373 pobj mice,from
R7435 T11375 T11370 prep during,collected
R7436 T11376 T11377 det a,infusion
R7437 T11377 T11375 pobj infusion,during
R7438 T11378 T11377 amod constant,infusion
R7439 T11379 T11377 prep of,infusion
R7440 T11380 T11379 pobj TUDC,of
R7441 T11381 T11370 cc and,collected
R7442 T11382 T11370 conj analyzed,collected
R7443 T11383 T11382 prep by,analyzed
R7444 T11384 T11383 pobj GC,by
R7445 T11385 T11370 punct .,collected
R7446 T11387 T11388 nsubjpass Mice,depleted
R7447 T11389 T11388 auxpass were,depleted
R7448 T11390 T11388 advmod first,depleted
R7449 T11391 T11388 prep of,depleted
R7450 T11392 T11393 poss their,pools
R7451 T11393 T11391 pobj pools,of
R7452 T11394 T11393 amod endogenous,pools
R7453 T11395 T11396 compound bile,acid
R7454 T11396 T11393 compound acid,pools
R7455 T11397 T11388 prep for,depleted
R7456 T11398 T11399 nummod 30,minutes
R7457 T11399 T11397 pobj minutes,for
R7458 T11400 T11401 advmod then,infused
R7459 T11401 T11388 dep infused,depleted
R7460 T11402 T11401 prep with,infused
R7461 T11403 T11404 det a,dose
R7462 T11404 T11402 pobj dose,with
R7463 T11405 T11404 amod continuous,dose
R7464 T11406 T11404 prep of,dose
R7465 T11407 T11406 pobj TUDC,of
R7466 T11408 T11409 punct (,nmol
R7467 T11409 T11388 parataxis nmol,depleted
R7468 T11410 T11409 nummod "1,200",nmol
R7469 T11411 T11412 punct /,min
R7470 T11412 T11409 prep min,nmol
R7471 T11413 T11414 punct /,weight
R7472 T11414 T11409 prep weight,nmol
R7473 T11415 T11416 compound 100,g
R7474 T11416 T11414 compound g,weight
R7475 T11417 T11414 compound body,weight
R7476 T11418 T11409 punct ),nmol
R7477 T11419 T11388 punct .,depleted
R7478 T11421 T11422 det The,mice
R7479 T11422 T11424 nsubj mice,showed
R7480 T11423 T11422 compound knockout,mice
R7481 T11425 T11426 det a,ability
R7482 T11426 T11424 dobj ability,showed
R7483 T11427 T11428 advmod significantly,diminished
R7484 T11428 T11426 amod diminished,ability
R7485 T11429 T11430 aux to,secrete
R7486 T11430 T11426 acl secrete,ability
R7487 T11431 T11430 dobj cholesterol,secrete
R7488 T11432 T11424 punct ", ",showed
R7489 T11433 T11424 cc yet,showed
R7490 T11434 T11435 advmod still,maintained
R7491 T11435 T11424 conj maintained,showed
R7492 T11436 T11437 det the,ability
R7493 T11437 T11435 dobj ability,maintained
R7494 T11438 T11439 aux to,secrete
R7495 T11439 T11437 acl secrete,ability
R7496 T11440 T11439 dobj sitosterol,secrete
R7497 T11441 T11440 cc and,sitosterol
R7498 T11442 T11440 conj campesterol,sitosterol
R7499 T11443 T11424 prep compared,showed
R7500 T11444 T11443 prep to,compared
R7501 T11445 T11446 amod wild,type
R7502 T11446 T11448 compound type,mice
R7503 T11447 T11446 punct -,type
R7504 T11448 T11444 pobj mice,to
R7505 T11449 T11450 punct (,Figure
R7506 T11450 T11424 parataxis Figure,showed
R7507 T11451 T11450 nummod 9,Figure
R7508 T11452 T11450 punct ),Figure
R7509 T11453 T11424 punct .,showed
R7510 T11455 T11456 advmod Surprisingly,tended
R7511 T11457 T11456 punct ", ",tended
R7512 T11458 T11459 det the,mice
R7513 T11459 T11456 nsubj mice,tended
R7514 T11460 T11459 nmod Abcg8,mice
R7515 T11461 T11460 punct +,Abcg8
R7516 T11462 T11460 punct /,Abcg8
R7517 T11463 T11460 punct -,Abcg8
R7518 T11464 T11465 aux to,show
R7519 T11465 T11456 xcomp show,tended
R7520 T11466 T11467 det an,ability
R7521 T11467 T11465 dobj ability,show
R7522 T11468 T11467 amod increased,ability
R7523 T11469 T11470 aux to,secrete
R7524 T11470 T11467 acl secrete,ability
R7525 T11471 T11472 det all,sterols
R7526 T11472 T11470 dobj sterols,secrete
R7527 T11473 T11470 prep above,secrete
R7528 T11474 T11475 det the,levels
R7529 T11475 T11473 pobj levels,above
R7530 T11476 T11475 acl seen,levels
R7531 T11477 T11476 prep in,seen
R7532 T11478 T11479 det the,mice
R7533 T11479 T11477 pobj mice,in
R7534 T11480 T11481 amod wild,type
R7535 T11481 T11479 compound type,mice
R7536 T11482 T11481 punct -,type
R7537 T11483 T11456 punct ", ",tended
R7538 T11484 T11485 mark although,was
R7539 T11485 T11456 advcl was,tended
R7540 T11486 T11485 nsubj this,was
R7541 T11487 T11485 neg not,was
R7542 T11488 T11489 advmod statistically,significant
R7543 T11489 T11485 acomp significant,was
R7544 T11490 T11456 punct .,tended