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PMC:394351 / 26782-27895 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T7584 0-12 JJ denotes Heterozygous
T7585 13-17 NNS denotes mice
T7586 18-22 VBD denotes were
T7587 23-30 JJ denotes fertile
T7588 31-34 CC denotes and
T7589 35-39 VBD denotes gave
T7590 40-44 NN denotes rise
T7591 45-47 IN denotes to
T7592 48-54 JJ denotes normal
T7594 55-61 JJ denotes litter
T7593 62-67 NNS denotes sizes
T7595 67-68 . denotes .
T7596 68-215 sentence denotes Breeding heterozygous animals led to wild-type, heterozygous and homozygous knockout mice in the expected Mendelian distribution (data not shown).
T7597 69-77 VBG denotes Breeding
T7599 78-90 JJ denotes heterozygous
T7600 91-98 NNS denotes animals
T7598 99-102 VBD denotes led
T7601 103-105 IN denotes to
T7602 106-110 JJ denotes wild
T7604 110-111 HYPH denotes -
T7603 111-115 NN denotes type
T7606 115-117 , denotes ,
T7607 117-129 JJ denotes heterozygous
T7609 130-133 CC denotes and
T7610 134-144 JJ denotes homozygous
T7608 145-153 NN denotes knockout
T7605 154-158 NNS denotes mice
T7611 159-161 IN denotes in
T7612 162-165 DT denotes the
T7614 166-174 VBN denotes expected
T7615 175-184 JJ denotes Mendelian
T7613 185-197 NN denotes distribution
T7616 198-199 -LRB- denotes (
T7618 199-203 NNS denotes data
T7619 204-207 RB denotes not
T7617 208-213 VBN denotes shown
T7620 213-214 -RRB- denotes )
T7621 214-215 . denotes .
T7622 215-385 sentence denotes Although not quantitative, Northern analyses showed that while the knockout mice showed no detectable mRNA for Abcg8, expression of Abcg5 appeared unaltered (Figure 1c).
T7623 216-224 IN denotes Although
T7625 225-228 RB denotes not
T7624 229-241 JJ denotes quantitative
T7627 241-243 , denotes ,
T7628 243-251 NNP denotes Northern
T7629 252-260 NNS denotes analyses
T7626 261-267 VBD denotes showed
T7630 268-272 IN denotes that
T7632 273-278 IN denotes while
T7634 279-282 DT denotes the
T7636 283-291 NN denotes knockout
T7635 292-296 NNS denotes mice
T7633 297-303 VBD denotes showed
T7637 304-306 DT denotes no
T7639 307-317 JJ denotes detectable
T7638 318-322 NN denotes mRNA
T7640 323-326 IN denotes for
T7641 327-332 NN denotes Abcg8
T7642 332-334 , denotes ,
T7643 334-344 NN denotes expression
T7644 345-347 IN denotes of
T7645 348-353 NN denotes Abcg5
T7631 354-362 VBD denotes appeared
T7646 363-372 JJ denotes unaltered
T7647 373-374 -LRB- denotes (
T7649 374-380 NN denotes Figure
T7648 381-383 NN denotes 1c
T7650 383-384 -RRB- denotes )
T7651 384-385 . denotes .
T7652 385-664 sentence denotes To exclude the possibility of alternative splicing with the production of a non-functional but truncated Abcg8/sterolin-2 protein that may serve as a chaperone for Abcg5/sterolin-1, RT-PCR was performed on cDNA reverse transcribed from total liver RNA from Abcg8-deficient mice.
T7653 386-388 TO denotes To
T7654 389-396 VB denotes exclude
T7656 397-400 DT denotes the
T7657 401-412 NN denotes possibility
T7658 413-415 IN denotes of
T7659 416-427 JJ denotes alternative
T7660 428-436 NN denotes splicing
T7661 437-441 IN denotes with
T7662 442-445 DT denotes the
T7663 446-456 NN denotes production
T7664 457-459 IN denotes of
T7665 460-461 DT denotes a
T7667 462-476 JJ denotes non-functional
T7668 477-480 CC denotes but
T7669 481-490 VBN denotes truncated
T7670 491-496 NN denotes Abcg8
T7672 496-497 HYPH denotes /
T7671 497-505 NN denotes sterolin
T7673 505-506 HYPH denotes -
T7674 506-507 CD denotes 2
T7666 508-515 NN denotes protein
T7675 516-520 WDT denotes that
T7677 521-524 MD denotes may
T7676 525-530 VB denotes serve
T7678 531-533 IN denotes as
T7679 534-535 DT denotes a
T7680 536-545 NN denotes chaperone
T7681 546-549 IN denotes for
T7682 550-555 NN denotes Abcg5
T7684 555-556 HYPH denotes /
T7683 556-564 NN denotes sterolin
T7685 564-565 HYPH denotes -
T7686 565-566 CD denotes 1
T7687 566-568 , denotes ,
T7688 568-570 NN denotes RT
T7690 570-571 HYPH denotes -
T7689 571-574 NN denotes PCR
T7691 575-578 VBD denotes was
T7655 579-588 VBN denotes performed
T7692 589-591 IN denotes on
T7693 592-596 NN denotes cDNA
T7694 597-604 RB denotes reverse
T7695 605-616 VBN denotes transcribed
T7696 617-621 IN denotes from
T7697 622-627 JJ denotes total
T7699 628-633 NN denotes liver
T7698 634-637 NN denotes RNA
T7700 638-642 IN denotes from
T7701 643-648 NN denotes Abcg8
T7703 648-649 HYPH denotes -
T7702 649-658 JJ denotes deficient
T7704 659-663 NNS denotes mice
T7705 663-664 . denotes .
T7706 664-879 sentence denotes No mRNA for Abcg8/sterolin-2 was detected containing any sequences downstream of exon 4 in the Abcg8-deficient mice, whether primers were located in exons 4 and 13, exons 9 and 13 or exons 10 and 13 (Figure 1d,1e).
T7707 665-667 DT denotes No
T7708 668-672 NN denotes mRNA
T7710 673-676 IN denotes for
T7711 677-682 NN denotes Abcg8
T7713 682-683 HYPH denotes /
T7712 683-691 NN denotes sterolin
T7714 691-692 HYPH denotes -
T7715 692-693 CD denotes 2
T7716 694-697 VBD denotes was
T7717 698-706 VBN denotes detected
T7709 707-717 VBG denotes containing
T7718 718-721 DT denotes any
T7719 722-731 NNS denotes sequences
T7720 732-742 RB denotes downstream
T7721 743-745 IN denotes of
T7722 746-750 NN denotes exon
T7723 751-752 CD denotes 4
T7724 753-755 IN denotes in
T7725 756-759 DT denotes the
T7727 760-765 NN denotes Abcg8
T7729 765-766 HYPH denotes -
T7728 766-775 JJ denotes deficient
T7726 776-780 NNS denotes mice
T7730 780-782 , denotes ,
T7731 782-789 IN denotes whether
T7733 790-797 NNS denotes primers
T7734 798-802 VBD denotes were
T7732 803-810 VBN denotes located
T7735 811-813 IN denotes in
T7736 814-819 NNS denotes exons
T7737 820-821 CD denotes 4
T7738 822-825 CC denotes and
T7739 826-828 CD denotes 13
T7740 828-830 , denotes ,
T7741 830-835 NNS denotes exons
T7742 836-837 CD denotes 9
T7743 838-841 CC denotes and
T7744 842-844 CD denotes 13
T7745 845-847 CC denotes or
T7746 848-853 NNS denotes exons
T7747 854-856 CD denotes 10
T7748 857-860 CC denotes and
T7749 861-863 CD denotes 13
T7750 864-865 -LRB- denotes (
T7752 865-871 NN denotes Figure
T7753 872-874 NN denotes 1d
T7754 874-875 , denotes ,
T7751 875-877 NN denotes 1e
T7755 877-878 -RRB- denotes )
T7756 878-879 . denotes .
T7757 879-1036 sentence denotes This demonstrates that if an alternatively spliced message could potentially code for a truncated protein, it is not detectable in the Abcg8-deficient mice.
T7758 880-884 DT denotes This
T7759 885-897 VBZ denotes demonstrates
T7760 898-902 IN denotes that
T7762 903-905 IN denotes if
T7764 906-908 DT denotes an
T7766 909-922 RB denotes alternatively
T7767 923-930 VBN denotes spliced
T7765 931-938 NN denotes message
T7768 939-944 MD denotes could
T7769 945-956 RB denotes potentially
T7763 957-961 VB denotes code
T7770 962-965 IN denotes for
T7771 966-967 DT denotes a
T7773 968-977 VBN denotes truncated
T7772 978-985 NN denotes protein
T7774 985-987 , denotes ,
T7775 987-989 PRP denotes it
T7761 990-992 VBZ denotes is
T7776 993-996 RB denotes not
T7777 997-1007 JJ denotes detectable
T7778 1008-1010 IN denotes in
T7779 1011-1014 DT denotes the
T7781 1015-1020 NN denotes Abcg8
T7783 1020-1021 HYPH denotes -
T7782 1021-1030 JJ denotes deficient
T7780 1031-1035 NNS denotes mice
T7784 1035-1036 . denotes .
T7785 1036-1113 sentence denotes The membrane-spanning domains of Abcg8/sterolin-2 are encoded by exons 9–13.
T7786 1037-1040 DT denotes The
T7788 1041-1049 NN denotes membrane
T7790 1049-1050 HYPH denotes -
T7789 1050-1058 VBG denotes spanning
T7787 1059-1066 NNS denotes domains
T7792 1067-1069 IN denotes of
T7793 1070-1075 NN denotes Abcg8
T7795 1075-1076 HYPH denotes /
T7794 1076-1084 NN denotes sterolin
T7796 1084-1085 HYPH denotes -
T7797 1085-1086 CD denotes 2
T7798 1087-1090 VBP denotes are
T7791 1091-1098 VBN denotes encoded
T7799 1099-1101 IN denotes by
T7800 1102-1107 NNS denotes exons
T7801 1108-1109 CD denotes 9
T7802 1109-1110 SYM denotes –
T7803 1110-1112 CD denotes 13
T7804 1112-1113 . denotes .
R5068 T7584 T7585 amod Heterozygous,mice
R5069 T7585 T7586 nsubj mice,were
R5070 T7587 T7586 acomp fertile,were
R5071 T7588 T7586 cc and,were
R5072 T7589 T7586 conj gave,were
R5073 T7590 T7589 dobj rise,gave
R5074 T7591 T7589 prep to,gave
R5075 T7592 T7593 amod normal,sizes
R5076 T7593 T7591 pobj sizes,to
R5077 T7594 T7593 amod litter,sizes
R5078 T7595 T7586 punct .,were
R5079 T7597 T7598 csubj Breeding,led
R5080 T7599 T7600 amod heterozygous,animals
R5081 T7600 T7597 dobj animals,Breeding
R5082 T7601 T7598 prep to,led
R5083 T7602 T7603 amod wild,type
R5084 T7603 T7605 nmod type,mice
R5085 T7604 T7603 punct -,type
R5086 T7605 T7601 pobj mice,to
R5087 T7606 T7603 punct ", ",type
R5088 T7607 T7608 amod heterozygous,knockout
R5089 T7608 T7603 appos knockout,type
R5090 T7609 T7607 cc and,heterozygous
R5091 T7610 T7607 conj homozygous,heterozygous
R5092 T7611 T7605 prep in,mice
R5093 T7612 T7613 det the,distribution
R5094 T7613 T7611 pobj distribution,in
R5095 T7614 T7613 amod expected,distribution
R5096 T7615 T7613 amod Mendelian,distribution
R5097 T7616 T7617 punct (,shown
R5098 T7617 T7598 parataxis shown,led
R5099 T7618 T7617 nsubj data,shown
R5100 T7619 T7617 neg not,shown
R5101 T7620 T7617 punct ),shown
R5102 T7621 T7598 punct .,led
R5103 T7623 T7624 mark Although,quantitative
R5104 T7624 T7626 advcl quantitative,showed
R5105 T7625 T7624 neg not,quantitative
R5106 T7627 T7626 punct ", ",showed
R5107 T7628 T7629 compound Northern,analyses
R5108 T7629 T7626 nsubj analyses,showed
R5109 T7630 T7631 mark that,appeared
R5110 T7631 T7626 ccomp appeared,showed
R5111 T7632 T7633 mark while,showed
R5112 T7633 T7631 advcl showed,appeared
R5113 T7634 T7635 det the,mice
R5114 T7635 T7633 nsubj mice,showed
R5115 T7636 T7635 compound knockout,mice
R5116 T7637 T7638 det no,mRNA
R5117 T7638 T7633 dobj mRNA,showed
R5118 T7639 T7638 amod detectable,mRNA
R5119 T7640 T7638 prep for,mRNA
R5120 T7641 T7640 pobj Abcg8,for
R5121 T7642 T7631 punct ", ",appeared
R5122 T7643 T7631 nsubj expression,appeared
R5123 T7644 T7643 prep of,expression
R5124 T7645 T7644 pobj Abcg5,of
R5125 T7646 T7631 oprd unaltered,appeared
R5126 T7647 T7648 punct (,1c
R5127 T7648 T7626 parataxis 1c,showed
R5128 T7649 T7648 compound Figure,1c
R5129 T7650 T7648 punct ),1c
R5130 T7651 T7626 punct .,showed
R5131 T7653 T7654 aux To,exclude
R5132 T7654 T7655 advcl exclude,performed
R5133 T7656 T7657 det the,possibility
R5134 T7657 T7654 dobj possibility,exclude
R5135 T7658 T7657 prep of,possibility
R5136 T7659 T7660 amod alternative,splicing
R5137 T7660 T7658 pobj splicing,of
R5138 T7661 T7660 prep with,splicing
R5139 T7662 T7663 det the,production
R5140 T7663 T7661 pobj production,with
R5141 T7664 T7663 prep of,production
R5142 T7665 T7666 det a,protein
R5143 T7666 T7664 pobj protein,of
R5144 T7667 T7666 amod non-functional,protein
R5145 T7668 T7667 cc but,non-functional
R5146 T7669 T7667 conj truncated,non-functional
R5147 T7670 T7671 nmod Abcg8,sterolin
R5148 T7671 T7666 nmod sterolin,protein
R5149 T7672 T7671 punct /,sterolin
R5150 T7673 T7671 punct -,sterolin
R5151 T7674 T7671 nummod 2,sterolin
R5152 T7675 T7676 dep that,serve
R5153 T7676 T7666 relcl serve,protein
R5154 T7677 T7676 aux may,serve
R5155 T7678 T7676 prep as,serve
R5156 T7679 T7680 det a,chaperone
R5157 T7680 T7678 pobj chaperone,as
R5158 T7681 T7680 prep for,chaperone
R5159 T7682 T7683 compound Abcg5,sterolin
R5160 T7683 T7681 pobj sterolin,for
R5161 T7684 T7683 punct /,sterolin
R5162 T7685 T7683 punct -,sterolin
R5163 T7686 T7683 nummod 1,sterolin
R5164 T7687 T7655 punct ", ",performed
R5165 T7688 T7689 compound RT,PCR
R5166 T7689 T7655 nsubjpass PCR,performed
R5167 T7690 T7689 punct -,PCR
R5168 T7691 T7655 auxpass was,performed
R5169 T7692 T7655 prep on,performed
R5170 T7693 T7692 pobj cDNA,on
R5171 T7694 T7695 advmod reverse,transcribed
R5172 T7695 T7693 acl transcribed,cDNA
R5173 T7696 T7695 prep from,transcribed
R5174 T7697 T7698 amod total,RNA
R5175 T7698 T7696 pobj RNA,from
R5176 T7699 T7698 compound liver,RNA
R5177 T7700 T7698 prep from,RNA
R5178 T7701 T7702 npadvmod Abcg8,deficient
R5179 T7702 T7704 amod deficient,mice
R5180 T7703 T7702 punct -,deficient
R5181 T7704 T7700 pobj mice,from
R5182 T7705 T7655 punct .,performed
R5183 T7707 T7708 det No,mRNA
R5184 T7708 T7709 nsubjpass mRNA,containing
R5185 T7710 T7708 prep for,mRNA
R5186 T7711 T7712 compound Abcg8,sterolin
R5187 T7712 T7710 pobj sterolin,for
R5188 T7713 T7712 punct /,sterolin
R5189 T7714 T7712 punct -,sterolin
R5190 T7715 T7712 nummod 2,sterolin
R5191 T7716 T7709 auxpass was,containing
R5192 T7717 T7709 aux detected,containing
R5193 T7718 T7719 det any,sequences
R5194 T7719 T7709 dobj sequences,containing
R5195 T7720 T7719 advmod downstream,sequences
R5196 T7721 T7720 prep of,downstream
R5197 T7722 T7721 pobj exon,of
R5198 T7723 T7722 nummod 4,exon
R5199 T7724 T7709 prep in,containing
R5200 T7725 T7726 det the,mice
R5201 T7726 T7724 pobj mice,in
R5202 T7727 T7728 npadvmod Abcg8,deficient
R5203 T7728 T7726 amod deficient,mice
R5204 T7729 T7728 punct -,deficient
R5205 T7730 T7709 punct ", ",containing
R5206 T7731 T7732 mark whether,located
R5207 T7732 T7709 advcl located,containing
R5208 T7733 T7732 nsubjpass primers,located
R5209 T7734 T7732 auxpass were,located
R5210 T7735 T7732 prep in,located
R5211 T7736 T7737 nmod exons,4
R5212 T7737 T7735 pobj 4,in
R5213 T7738 T7737 cc and,4
R5214 T7739 T7737 conj 13,4
R5215 T7740 T7737 punct ", ",4
R5216 T7741 T7742 nmod exons,9
R5217 T7742 T7737 conj 9,4
R5218 T7743 T7742 cc and,9
R5219 T7744 T7742 conj 13,9
R5220 T7745 T7742 cc or,9
R5221 T7746 T7747 nmod exons,10
R5222 T7747 T7742 conj 10,9
R5223 T7748 T7747 cc and,10
R5224 T7749 T7747 conj 13,10
R5225 T7750 T7751 punct (,1e
R5226 T7751 T7709 parataxis 1e,containing
R5227 T7752 T7751 nmod Figure,1e
R5228 T7753 T7751 nmod 1d,1e
R5229 T7754 T7751 punct ",",1e
R5230 T7755 T7751 punct ),1e
R5231 T7756 T7709 punct .,containing
R5232 T7758 T7759 nsubj This,demonstrates
R5233 T7760 T7761 mark that,is
R5234 T7761 T7759 ccomp is,demonstrates
R5235 T7762 T7763 mark if,code
R5236 T7763 T7761 advcl code,is
R5237 T7764 T7765 det an,message
R5238 T7765 T7763 nsubj message,code
R5239 T7766 T7767 advmod alternatively,spliced
R5240 T7767 T7765 amod spliced,message
R5241 T7768 T7763 aux could,code
R5242 T7769 T7763 advmod potentially,code
R5243 T7770 T7763 prep for,code
R5244 T7771 T7772 det a,protein
R5245 T7772 T7770 pobj protein,for
R5246 T7773 T7772 amod truncated,protein
R5247 T7774 T7761 punct ", ",is
R5248 T7775 T7761 nsubj it,is
R5249 T7776 T7761 neg not,is
R5250 T7777 T7761 acomp detectable,is
R5251 T7778 T7761 prep in,is
R5252 T7779 T7780 det the,mice
R5253 T7780 T7778 pobj mice,in
R5254 T7781 T7782 npadvmod Abcg8,deficient
R5255 T7782 T7780 amod deficient,mice
R5256 T7783 T7782 punct -,deficient
R5257 T7784 T7759 punct .,demonstrates
R5258 T7786 T7787 det The,domains
R5259 T7787 T7791 nsubjpass domains,encoded
R5260 T7788 T7789 npadvmod membrane,spanning
R5261 T7789 T7787 amod spanning,domains
R5262 T7790 T7789 punct -,spanning
R5263 T7792 T7787 prep of,domains
R5264 T7793 T7794 compound Abcg8,sterolin
R5265 T7794 T7792 pobj sterolin,of
R5266 T7795 T7794 punct /,sterolin
R5267 T7796 T7794 punct -,sterolin
R5268 T7797 T7794 nummod 2,sterolin
R5269 T7798 T7791 auxpass are,encoded
R5270 T7799 T7791 agent by,encoded
R5271 T7800 T7801 nmod exons,9
R5272 T7801 T7799 pobj 9,by
R5273 T7802 T7803 punct –,13
R5274 T7803 T7801 prep 13,9
R5275 T7804 T7791 punct .,encoded