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PMC:149366 / 31930-33215 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue
T7065 0-9 NN denotes Relevance
T7066 10-12 IN denotes of
T7067 13-16 PRP$ denotes our
T7068 17-25 NNS denotes findings
T7069 26-28 IN denotes to
T7070 29-34 JJ denotes other
T7071 35-44 NNS denotes mutations
T7072 45-49 IN denotes with
T7073 50-54 NN denotes hair
T7074 55-59 NN denotes cell
T7075 60-64 NN denotes loss
T7076 64-238 sentence denotes Vahava et al. [12] and Frydman et al. [34] have demonstrated that mutation in a single human allele of Pou4f3 (Brn3c) results in a late onset of high frequency hearing loss.
T7077 65-71 NNP denotes Vahava
T7079 72-74 FW denotes et
T7080 75-78 FW denotes al.
T7081 79-80 -LRB- denotes [
T7082 80-82 CD denotes 12
T7083 82-83 -RRB- denotes ]
T7084 84-87 CC denotes and
T7085 88-95 NNP denotes Frydman
T7086 96-98 FW denotes et
T7087 99-102 FW denotes al.
T7088 103-104 -LRB- denotes [
T7089 104-106 CD denotes 34
T7090 106-107 -RRB- denotes ]
T7091 108-112 VBP denotes have
T7078 113-125 VBN denotes demonstrated
T7092 126-130 IN denotes that
T7094 131-139 NN denotes mutation
T7095 140-142 IN denotes in
T7096 143-144 DT denotes a
T7098 145-151 JJ denotes single
T7099 152-157 JJ denotes human
T7097 158-164 NN denotes allele
T7100 165-167 IN denotes of
T7101 168-174 NN denotes Pou4f3
T7102 175-176 -LRB- denotes (
T7103 176-181 NN denotes Brn3c
T7104 181-182 -RRB- denotes )
T7093 183-190 VBZ denotes results
T7105 191-193 IN denotes in
T7106 194-195 DT denotes a
T7108 196-200 JJ denotes late
T7107 201-206 NN denotes onset
T7109 207-209 IN denotes of
T7110 210-214 JJ denotes high
T7111 215-224 NN denotes frequency
T7113 225-232 NN denotes hearing
T7112 233-237 NN denotes loss
T7114 237-238 . denotes .
T7115 238-358 sentence denotes Thus far no data are available that correlate the late onset of hearing loss with morphological defects in the cochlea.
T7116 239-243 RB denotes Thus
T7117 244-247 RB denotes far
T7119 248-250 DT denotes no
T7120 251-255 NNS denotes data
T7118 256-259 VBP denotes are
T7121 260-269 JJ denotes available
T7122 270-274 WDT denotes that
T7123 275-284 VBP denotes correlate
T7124 285-288 DT denotes the
T7126 289-293 JJ denotes late
T7125 294-299 NN denotes onset
T7127 300-302 IN denotes of
T7128 303-310 NN denotes hearing
T7129 311-315 NN denotes loss
T7130 316-320 IN denotes with
T7131 321-334 JJ denotes morphological
T7132 335-342 NNS denotes defects
T7133 343-345 IN denotes in
T7134 346-349 DT denotes the
T7135 350-357 NN denotes cochlea
T7136 357-358 . denotes .
T7137 358-502 sentence denotes In fact, an investigation of Brn3c heterozygotic mice showed no additional effect on hearing loss due to haploinsufficiency in these mice [35].
T7138 359-361 IN denotes In
T7140 362-366 NN denotes fact
T7141 366-368 , denotes ,
T7142 368-370 DT denotes an
T7143 371-384 NN denotes investigation
T7144 385-387 IN denotes of
T7145 388-393 NN denotes Brn3c
T7147 394-407 JJ denotes heterozygotic
T7146 408-412 NNS denotes mice
T7139 413-419 VBD denotes showed
T7148 420-422 DT denotes no
T7150 423-433 JJ denotes additional
T7149 434-440 NN denotes effect
T7151 441-443 IN denotes on
T7152 444-451 NN denotes hearing
T7153 452-456 NN denotes loss
T7154 457-460 IN denotes due
T7155 461-463 IN denotes to
T7156 464-482 NN denotes haploinsufficiency
T7157 483-485 IN denotes in
T7158 486-491 DT denotes these
T7159 492-496 NNS denotes mice
T7160 497-498 -LRB- denotes [
T7161 498-500 CD denotes 35
T7162 500-501 -RRB- denotes ]
T7163 501-502 . denotes .
T7164 502-726 sentence denotes Our data on Brn3c null mouse mutants nevertheless suggest that the high to low frequency progressive hearing loss in humans may correlate with the unknown factor(s) that mediate apical spiral neuron survival into adulthood.
T7165 503-506 PRP$ denotes Our
T7166 507-511 NNS denotes data
T7168 512-514 IN denotes on
T7169 515-520 NN denotes Brn3c
T7171 521-525 JJ denotes null
T7172 526-531 NN denotes mouse
T7170 532-539 NNS denotes mutants
T7173 540-552 RB denotes nevertheless
T7167 553-560 VBP denotes suggest
T7174 561-565 IN denotes that
T7176 566-569 DT denotes the
T7178 570-574 JJ denotes high
T7180 575-577 IN denotes to
T7181 578-581 JJ denotes low
T7179 582-591 NN denotes frequency
T7182 592-603 JJ denotes progressive
T7183 604-611 NN denotes hearing
T7177 612-616 NN denotes loss
T7184 617-619 IN denotes in
T7185 620-626 NNS denotes humans
T7186 627-630 MD denotes may
T7175 631-640 VB denotes correlate
T7187 641-645 IN denotes with
T7188 646-649 DT denotes the
T7190 650-657 JJ denotes unknown
T7189 658-664 NN denotes factor
T7191 664-665 -LRB- denotes (
T7192 665-666 AFX denotes s
T7193 666-667 -RRB- denotes )
T7194 668-672 WDT denotes that
T7195 673-680 VBP denotes mediate
T7196 681-687 JJ denotes apical
T7198 688-694 JJ denotes spiral
T7197 695-701 NN denotes neuron
T7199 702-710 NN denotes survival
T7200 711-715 IN denotes into
T7201 716-725 NN denotes adulthood
T7202 725-726 . denotes .
T7203 726-903 sentence denotes Quantitative data on human Pou4f3 cochleae is needed to verify that spiral neuron loss is more pronounced in the basal, high frequency area of these hearing-deficient patients.
T7204 727-739 JJ denotes Quantitative
T7205 740-744 NNS denotes data
T7207 745-747 IN denotes on
T7208 748-753 JJ denotes human
T7210 754-760 NN denotes Pou4f3
T7209 761-769 NNS denotes cochleae
T7211 770-772 VBZ denotes is
T7206 773-779 VBN denotes needed
T7212 780-782 TO denotes to
T7213 783-789 VB denotes verify
T7214 790-794 IN denotes that
T7216 795-801 JJ denotes spiral
T7217 802-808 NN denotes neuron
T7218 809-813 NN denotes loss
T7215 814-816 VBZ denotes is
T7219 817-821 RBR denotes more
T7220 822-832 JJ denotes pronounced
T7221 833-835 IN denotes in
T7222 836-839 DT denotes the
T7224 840-845 JJ denotes basal
T7225 845-847 , denotes ,
T7226 847-851 JJ denotes high
T7227 852-861 NN denotes frequency
T7223 862-866 NN denotes area
T7228 867-869 IN denotes of
T7229 870-875 DT denotes these
T7231 876-883 NN denotes hearing
T7233 883-884 HYPH denotes -
T7232 884-893 JJ denotes deficient
T7230 894-902 NNS denotes patients
T7234 902-903 . denotes .
T7235 903-1006 sentence denotes Similar data are also needed for other congenitally deaf children [36] and in the deaf white cat [25].
T7236 904-911 JJ denotes Similar
T7237 912-916 NNS denotes data
T7239 917-920 VBP denotes are
T7240 921-925 RB denotes also
T7238 926-932 VBN denotes needed
T7241 933-936 IN denotes for
T7242 937-942 JJ denotes other
T7244 943-955 RB denotes congenitally
T7245 956-960 JJ denotes deaf
T7243 961-969 NNS denotes children
T7246 970-971 -LRB- denotes [
T7247 971-973 CD denotes 36
T7248 973-974 -RRB- denotes ]
T7249 975-978 CC denotes and
T7250 979-981 IN denotes in
T7251 982-985 DT denotes the
T7253 986-990 NN denotes deaf
T7254 991-996 JJ denotes white
T7252 997-1000 NN denotes cat
T7255 1001-1002 -LRB- denotes [
T7256 1002-1004 CD denotes 25
T7257 1004-1005 -RRB- denotes ]
T7258 1005-1006 . denotes .
T7259 1006-1285 sentence denotes Further work on the recently available mutant mice with specific absence of all hair cells [37], outer hair cells in the base [38] or apex [39] could further help to clarify the role of hair cells in forming and maintaining afferent and efferent innervation in these model mice.
T7260 1007-1014 JJ denotes Further
T7261 1015-1019 NN denotes work
T7263 1020-1022 IN denotes on
T7264 1023-1026 DT denotes the
T7266 1027-1035 RB denotes recently
T7267 1036-1045 JJ denotes available
T7268 1046-1052 JJ denotes mutant
T7265 1053-1057 NNS denotes mice
T7269 1058-1062 IN denotes with
T7270 1063-1071 JJ denotes specific
T7271 1072-1079 NN denotes absence
T7272 1080-1082 IN denotes of
T7273 1083-1086 DT denotes all
T7275 1087-1091 NN denotes hair
T7274 1092-1097 NNS denotes cells
T7276 1098-1099 -LRB- denotes [
T7277 1099-1101 CD denotes 37
T7278 1101-1102 -RRB- denotes ]
T7279 1102-1104 , denotes ,
T7280 1104-1109 JJ denotes outer
T7282 1110-1114 NN denotes hair
T7281 1115-1120 NNS denotes cells
T7283 1121-1123 IN denotes in
T7284 1124-1127 DT denotes the
T7285 1128-1132 NN denotes base
T7286 1133-1134 -LRB- denotes [
T7287 1134-1136 CD denotes 38
T7288 1136-1137 -RRB- denotes ]
T7289 1138-1140 CC denotes or
T7290 1141-1145 NN denotes apex
T7291 1146-1147 -LRB- denotes [
T7292 1147-1149 CD denotes 39
T7293 1149-1150 -RRB- denotes ]
T7294 1151-1156 MD denotes could
T7295 1157-1164 RB denotes further
T7262 1165-1169 VB denotes help
T7296 1170-1172 TO denotes to
T7297 1173-1180 VB denotes clarify
T7298 1181-1184 DT denotes the
T7299 1185-1189 NN denotes role
T7300 1190-1192 IN denotes of
T7301 1193-1197 NN denotes hair
T7302 1198-1203 NNS denotes cells
T7303 1204-1206 IN denotes in
T7304 1207-1214 VBG denotes forming
T7305 1215-1218 CC denotes and
T7306 1219-1230 VBG denotes maintaining
T7307 1231-1239 JJ denotes afferent
T7309 1240-1243 CC denotes and
T7310 1244-1252 JJ denotes efferent
T7308 1253-1264 NN denotes innervation
T7311 1265-1267 IN denotes in
T7312 1268-1273 DT denotes these
T7314 1274-1279 NN denotes model
T7313 1280-1284 NNS denotes mice
T7315 1284-1285 . denotes .
R4535 T7066 T7065 prep of,Relevance
R4536 T7067 T7068 poss our,findings
R4537 T7068 T7066 pobj findings,of
R4538 T7069 T7065 prep to,Relevance
R4539 T7070 T7071 amod other,mutations
R4540 T7071 T7069 pobj mutations,to
R4541 T7072 T7071 prep with,mutations
R4542 T7073 T7074 compound hair,cell
R4543 T7074 T7075 compound cell,loss
R4544 T7075 T7072 pobj loss,with
R4545 T7077 T7078 nsubj Vahava,demonstrated
R4546 T7079 T7080 advmod et,al.
R4547 T7080 T7077 advmod al.,Vahava
R4548 T7081 T7082 punct [,12
R4549 T7082 T7077 parataxis 12,Vahava
R4550 T7083 T7082 punct ],12
R4551 T7084 T7077 cc and,Vahava
R4552 T7085 T7077 conj Frydman,Vahava
R4553 T7086 T7087 advmod et,al.
R4554 T7087 T7085 advmod al.,Frydman
R4555 T7088 T7089 punct [,34
R4556 T7089 T7085 parataxis 34,Frydman
R4557 T7090 T7089 punct ],34
R4558 T7091 T7078 aux have,demonstrated
R4559 T7092 T7093 mark that,results
R4560 T7093 T7078 ccomp results,demonstrated
R4561 T7094 T7093 nsubj mutation,results
R4562 T7095 T7094 prep in,mutation
R4563 T7096 T7097 det a,allele
R4564 T7097 T7095 pobj allele,in
R4565 T7098 T7097 amod single,allele
R4566 T7099 T7097 amod human,allele
R4567 T7100 T7097 prep of,allele
R4568 T7101 T7100 pobj Pou4f3,of
R4569 T7102 T7097 punct (,allele
R4570 T7103 T7097 appos Brn3c,allele
R4571 T7104 T7093 punct ),results
R4572 T7105 T7093 prep in,results
R4573 T7106 T7107 det a,onset
R4574 T7107 T7105 pobj onset,in
R4575 T7108 T7107 amod late,onset
R4576 T7109 T7107 prep of,onset
R4577 T7110 T7111 amod high,frequency
R4578 T7111 T7112 compound frequency,loss
R4579 T7112 T7109 pobj loss,of
R4580 T7113 T7112 compound hearing,loss
R4581 T7114 T7078 punct .,demonstrated
R4582 T7116 T7117 advmod Thus,far
R4583 T7117 T7118 advmod far,are
R4584 T7119 T7120 det no,data
R4585 T7120 T7118 nsubj data,are
R4586 T7121 T7118 acomp available,are
R4587 T7122 T7123 dep that,correlate
R4588 T7123 T7118 ccomp correlate,are
R4589 T7124 T7125 det the,onset
R4590 T7125 T7123 dobj onset,correlate
R4591 T7126 T7125 amod late,onset
R4592 T7127 T7125 prep of,onset
R4593 T7128 T7129 compound hearing,loss
R4594 T7129 T7127 pobj loss,of
R4595 T7130 T7123 prep with,correlate
R4596 T7131 T7132 amod morphological,defects
R4597 T7132 T7130 pobj defects,with
R4598 T7133 T7132 prep in,defects
R4599 T7134 T7135 det the,cochlea
R4600 T7135 T7133 pobj cochlea,in
R4601 T7136 T7118 punct .,are
R4602 T7138 T7139 prep In,showed
R4603 T7140 T7138 pobj fact,In
R4604 T7141 T7139 punct ", ",showed
R4605 T7142 T7143 det an,investigation
R4606 T7143 T7139 nsubj investigation,showed
R4607 T7144 T7143 prep of,investigation
R4608 T7145 T7146 nmod Brn3c,mice
R4609 T7146 T7144 pobj mice,of
R4610 T7147 T7146 amod heterozygotic,mice
R4611 T7148 T7149 det no,effect
R4612 T7149 T7139 dobj effect,showed
R4613 T7150 T7149 amod additional,effect
R4614 T7151 T7149 prep on,effect
R4615 T7152 T7153 compound hearing,loss
R4616 T7153 T7151 pobj loss,on
R4617 T7154 T7149 prep due,effect
R4618 T7155 T7154 pcomp to,due
R4619 T7156 T7154 pobj haploinsufficiency,due
R4620 T7157 T7156 prep in,haploinsufficiency
R4621 T7158 T7159 det these,mice
R4622 T7159 T7157 pobj mice,in
R4623 T7160 T7161 punct [,35
R4624 T7161 T7139 parataxis 35,showed
R4625 T7162 T7161 punct ],35
R4626 T7163 T7139 punct .,showed
R4627 T7165 T7166 poss Our,data
R4628 T7166 T7167 nsubj data,suggest
R4629 T7168 T7166 prep on,data
R4630 T7169 T7170 nmod Brn3c,mutants
R4631 T7170 T7168 pobj mutants,on
R4632 T7171 T7170 amod null,mutants
R4633 T7172 T7170 compound mouse,mutants
R4634 T7173 T7167 advmod nevertheless,suggest
R4635 T7174 T7175 mark that,correlate
R4636 T7175 T7167 ccomp correlate,suggest
R4637 T7176 T7177 det the,loss
R4638 T7177 T7175 nsubj loss,correlate
R4639 T7178 T7179 amod high,frequency
R4640 T7179 T7177 nmod frequency,loss
R4641 T7180 T7178 prep to,high
R4642 T7181 T7180 amod low,to
R4643 T7182 T7177 amod progressive,loss
R4644 T7183 T7177 compound hearing,loss
R4645 T7184 T7177 prep in,loss
R4646 T7185 T7184 pobj humans,in
R4647 T7186 T7175 aux may,correlate
R4648 T7187 T7175 prep with,correlate
R4649 T7188 T7189 det the,factor
R4650 T7189 T7187 pobj factor,with
R4651 T7190 T7189 amod unknown,factor
R4652 T7191 T7189 punct (,factor
R4653 T7192 T7189 nmod s,factor
R4654 T7193 T7189 punct ),factor
R4655 T7194 T7195 dep that,mediate
R4656 T7195 T7189 relcl mediate,factor
R4657 T7196 T7197 amod apical,neuron
R4658 T7197 T7199 compound neuron,survival
R4659 T7198 T7197 amod spiral,neuron
R4660 T7199 T7195 dobj survival,mediate
R4661 T7200 T7195 prep into,mediate
R4662 T7201 T7200 pobj adulthood,into
R4663 T7202 T7167 punct .,suggest
R4664 T7204 T7205 amod Quantitative,data
R4665 T7205 T7206 nsubjpass data,needed
R4666 T7207 T7205 prep on,data
R4667 T7208 T7209 amod human,cochleae
R4668 T7209 T7207 pobj cochleae,on
R4669 T7210 T7209 compound Pou4f3,cochleae
R4670 T7211 T7206 auxpass is,needed
R4671 T7212 T7213 aux to,verify
R4672 T7213 T7206 advcl verify,needed
R4673 T7214 T7215 mark that,is
R4674 T7215 T7213 ccomp is,verify
R4675 T7216 T7217 amod spiral,neuron
R4676 T7217 T7218 compound neuron,loss
R4677 T7218 T7215 nsubj loss,is
R4678 T7219 T7220 advmod more,pronounced
R4679 T7220 T7215 acomp pronounced,is
R4680 T7221 T7215 prep in,is
R4681 T7222 T7223 det the,area
R4682 T7223 T7221 pobj area,in
R4683 T7224 T7223 amod basal,area
R4684 T7225 T7223 punct ", ",area
R4685 T7226 T7227 amod high,frequency
R4686 T7227 T7223 compound frequency,area
R4687 T7228 T7223 prep of,area
R4688 T7229 T7230 det these,patients
R4689 T7230 T7228 pobj patients,of
R4690 T7231 T7232 npadvmod hearing,deficient
R4691 T7232 T7230 amod deficient,patients
R4692 T7233 T7232 punct -,deficient
R4693 T7234 T7206 punct .,needed
R4694 T7236 T7237 amod Similar,data
R4695 T7237 T7238 nsubjpass data,needed
R4696 T7239 T7238 auxpass are,needed
R4697 T7240 T7238 advmod also,needed
R4698 T7241 T7238 prep for,needed
R4699 T7242 T7243 amod other,children
R4700 T7243 T7241 pobj children,for
R4701 T7244 T7245 advmod congenitally,deaf
R4702 T7245 T7243 amod deaf,children
R4703 T7246 T7247 punct [,36
R4704 T7247 T7241 parataxis 36,for
R4705 T7248 T7247 punct ],36
R4706 T7249 T7241 cc and,for
R4707 T7250 T7241 conj in,for
R4708 T7251 T7252 det the,cat
R4709 T7252 T7250 pobj cat,in
R4710 T7253 T7252 nmod deaf,cat
R4711 T7254 T7252 amod white,cat
R4712 T7255 T7256 punct [,25
R4713 T7256 T7250 parataxis 25,in
R4714 T7257 T7256 punct ],25
R4715 T7258 T7238 punct .,needed
R4716 T7260 T7261 amod Further,work
R4717 T7261 T7262 nsubj work,help
R4718 T7263 T7261 prep on,work
R4719 T7264 T7265 det the,mice
R4720 T7265 T7263 pobj mice,on
R4721 T7266 T7267 advmod recently,available
R4722 T7267 T7265 amod available,mice
R4723 T7268 T7265 amod mutant,mice
R4724 T7269 T7265 prep with,mice
R4725 T7270 T7271 amod specific,absence
R4726 T7271 T7269 pobj absence,with
R4727 T7272 T7271 prep of,absence
R4728 T7273 T7274 det all,cells
R4729 T7274 T7272 pobj cells,of
R4730 T7275 T7274 compound hair,cells
R4731 T7276 T7277 punct [,37
R4732 T7277 T7274 parataxis 37,cells
R4733 T7278 T7277 punct ],37
R4734 T7279 T7274 punct ", ",cells
R4735 T7280 T7281 amod outer,cells
R4736 T7281 T7274 appos cells,cells
R4737 T7282 T7281 compound hair,cells
R4738 T7283 T7281 prep in,cells
R4739 T7284 T7285 det the,base
R4740 T7285 T7283 pobj base,in
R4741 T7286 T7287 punct [,38
R4742 T7287 T7285 parataxis 38,base
R4743 T7288 T7287 punct ],38
R4744 T7289 T7285 cc or,base
R4745 T7290 T7285 conj apex,base
R4746 T7291 T7292 punct [,39
R4747 T7292 T7290 parataxis 39,apex
R4748 T7293 T7292 punct ],39
R4749 T7294 T7262 aux could,help
R4750 T7295 T7262 advmod further,help
R4751 T7296 T7297 aux to,clarify
R4752 T7297 T7262 xcomp clarify,help
R4753 T7298 T7299 det the,role
R4754 T7299 T7297 dobj role,clarify
R4755 T7300 T7299 prep of,role
R4756 T7301 T7302 compound hair,cells
R4757 T7302 T7300 pobj cells,of
R4758 T7303 T7299 prep in,role
R4759 T7304 T7303 pcomp forming,in
R4760 T7305 T7304 cc and,forming
R4761 T7306 T7304 conj maintaining,forming
R4762 T7307 T7308 amod afferent,innervation
R4763 T7308 T7306 dobj innervation,maintaining
R4764 T7309 T7307 cc and,afferent
R4765 T7310 T7307 conj efferent,afferent
R4766 T7311 T7299 prep in,role
R4767 T7312 T7313 det these,mice
R4768 T7313 T7311 pobj mice,in
R4769 T7314 T7313 compound model,mice
R4770 T7315 T7262 punct .,help