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PMC:1253828 / 30304-31205 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T10117 0-5 NN denotes Ndrg1
T10119 5-7 , denotes ,
T10120 7-14 DT denotes another
T10122 15-26 JJ denotes interesting
T10123 27-30 NN denotes MTF
T10124 30-31 HYPH denotes -
T10125 31-32 CD denotes 1
T10126 33-39 NN denotes target
T10121 40-44 NN denotes gene
T10127 45-48 VBD denotes was
T10118 49-54 VBN denotes named
T10128 55-56 NN denotes N
T10130 56-57 HYPH denotes -
T10129 57-60 NN denotes myc
T10132 61-71 RB denotes downstream
T10133 72-81 VBN denotes regulated
T10131 82-86 NN denotes gene
T10134 87-88 CD denotes 1
T10135 89-98 VBG denotes following
T10136 99-102 DT denotes the
T10137 103-112 NN denotes discovery
T10138 113-117 IN denotes that
T10140 118-121 DT denotes the
T10142 122-135 NN denotes transcription
T10141 136-142 NN denotes factor
T10143 143-144 NN denotes N
T10145 144-145 HYPH denotes -
T10144 145-148 NN denotes myc
T10139 149-158 VBZ denotes represses
T10146 159-162 DT denotes the
T10147 163-173 NN denotes expression
T10148 174-176 IN denotes of
T10149 177-182 NN denotes mouse
T10150 183-188 NN denotes Ndrg1
T10151 189-190 -LRB- denotes (
T10152 190-192 CD denotes 51
T10153 192-193 -RRB- denotes )
T10154 193-194 . denotes .
T10155 194-384 sentence denotes Transcription of Ndrg1 and/or its human ortholog is induced by different physiological and cell stress conditions, such as androgens, nickel compounds, DNA damage and hypoxia (37–40,52,53).
T10156 195-208 NN denotes Transcription
T10158 209-211 IN denotes of
T10159 212-217 NN denotes Ndrg1
T10160 218-221 CC denotes and
T10161 221-222 HYPH denotes /
T10162 222-224 CC denotes or
T10163 225-228 PRP$ denotes its
T10165 229-234 JJ denotes human
T10164 235-243 NN denotes ortholog
T10166 244-246 VBZ denotes is
T10157 247-254 VBN denotes induced
T10167 255-257 IN denotes by
T10168 258-267 JJ denotes different
T10170 268-281 JJ denotes physiological
T10171 282-285 CC denotes and
T10172 286-290 NN denotes cell
T10173 291-297 NN denotes stress
T10169 298-308 NNS denotes conditions
T10174 308-310 , denotes ,
T10175 310-314 JJ denotes such
T10176 315-317 IN denotes as
T10177 318-327 NNS denotes androgens
T10178 327-329 , denotes ,
T10179 329-335 NN denotes nickel
T10180 336-345 NNS denotes compounds
T10181 345-347 , denotes ,
T10182 347-350 NN denotes DNA
T10183 351-357 NN denotes damage
T10184 358-361 CC denotes and
T10185 362-369 NN denotes hypoxia
T10186 370-371 -LRB- denotes (
T10188 371-373 CD denotes 37
T10189 373-374 SYM denotes –
T10190 374-376 CD denotes 40
T10191 376-377 , denotes ,
T10192 377-379 CD denotes 52
T10193 379-380 , denotes ,
T10187 380-382 CD denotes 53
T10194 382-383 -RRB- denotes )
T10195 383-384 . denotes .
T10196 384-518 sentence denotes In addition, the protein is overexpressed in human cancers of many tissues, such as lung, liver, brain, breast, kidney and skin (40).
T10197 385-387 IN denotes In
T10199 388-396 NN denotes addition
T10200 396-398 , denotes ,
T10201 398-401 DT denotes the
T10202 402-409 NN denotes protein
T10203 410-412 VBZ denotes is
T10198 413-426 VBN denotes overexpressed
T10204 427-429 IN denotes in
T10205 430-435 JJ denotes human
T10206 436-443 NNS denotes cancers
T10207 444-446 IN denotes of
T10208 447-451 JJ denotes many
T10209 452-459 NNS denotes tissues
T10210 459-461 , denotes ,
T10211 461-465 JJ denotes such
T10212 466-468 IN denotes as
T10213 469-473 NN denotes lung
T10214 473-475 , denotes ,
T10215 475-480 NN denotes liver
T10216 480-482 , denotes ,
T10217 482-487 NN denotes brain
T10218 487-489 , denotes ,
T10219 489-495 NN denotes breast
T10220 495-497 , denotes ,
T10221 497-503 NN denotes kidney
T10222 504-507 CC denotes and
T10223 508-512 NN denotes skin
T10224 513-514 -LRB- denotes (
T10225 514-516 CD denotes 40
T10226 516-517 -RRB- denotes )
T10227 517-518 . denotes .
T10228 518-743 sentence denotes Although Ndrg1 and especially its human ortholog have been quite intensely studied, its function remains unclear; however, the induction by stimuli like nickel and hypoxia suggests an involvement in the cell stress response.
T10229 519-527 IN denotes Although
T10231 528-533 NN denotes Ndrg1
T10232 534-537 CC denotes and
T10233 538-548 RB denotes especially
T10235 549-552 PRP$ denotes its
T10236 553-558 JJ denotes human
T10234 559-567 NN denotes ortholog
T10237 568-572 VBP denotes have
T10238 573-577 VBN denotes been
T10239 578-583 RB denotes quite
T10240 584-593 RB denotes intensely
T10230 594-601 VBN denotes studied
T10242 601-603 , denotes ,
T10243 603-606 PRP$ denotes its
T10244 607-615 NN denotes function
T10241 616-623 VBZ denotes remains
T10246 624-631 JJ denotes unclear
T10247 631-632 : denotes ;
T10248 633-640 RB denotes however
T10249 640-642 , denotes ,
T10250 642-645 DT denotes the
T10251 646-655 NN denotes induction
T10252 656-658 IN denotes by
T10253 659-666 NNS denotes stimuli
T10254 667-671 IN denotes like
T10255 672-678 NN denotes nickel
T10256 679-682 CC denotes and
T10257 683-690 NN denotes hypoxia
T10245 691-699 VBZ denotes suggests
T10258 700-702 DT denotes an
T10259 703-714 NN denotes involvement
T10260 715-717 IN denotes in
T10261 718-721 DT denotes the
T10263 722-726 NN denotes cell
T10264 727-733 NN denotes stress
T10262 734-742 NN denotes response
T10265 742-743 . denotes .
T10266 743-901 sentence denotes Such a role is strongly endorsed by our finding that Ndrg1 gene expression is also induced by cadmium, and that MTF-1 plays a crucial role in this induction.
T10267 744-748 PDT denotes Such
T10269 749-750 DT denotes a
T10268 751-755 NN denotes role
T10271 756-758 VBZ denotes is
T10272 759-767 RB denotes strongly
T10270 768-776 VBN denotes endorsed
T10273 777-779 IN denotes by
T10274 780-783 PRP$ denotes our
T10275 784-791 NN denotes finding
T10276 792-796 IN denotes that
T10278 797-802 NN denotes Ndrg1
T10280 803-807 NN denotes gene
T10279 808-818 NN denotes expression
T10281 819-821 VBZ denotes is
T10282 822-826 RB denotes also
T10277 827-834 VBN denotes induced
T10283 835-837 IN denotes by
T10284 838-845 NN denotes cadmium
T10285 845-847 , denotes ,
T10286 847-850 CC denotes and
T10287 851-855 IN denotes that
T10289 856-859 NN denotes MTF
T10290 859-860 HYPH denotes -
T10291 860-861 CD denotes 1
T10288 862-867 VBZ denotes plays
T10292 868-869 DT denotes a
T10294 870-877 JJ denotes crucial
T10293 878-882 NN denotes role
T10295 883-885 IN denotes in
T10296 886-890 DT denotes this
T10297 891-900 NN denotes induction
T10298 900-901 . denotes .
R5876 T10117 T10118 nsubjpass Ndrg1,named
R5877 T10119 T10117 punct ", ",Ndrg1
R5878 T10120 T10121 det another,gene
R5879 T10121 T10117 appos gene,Ndrg1
R5880 T10122 T10121 amod interesting,gene
R5881 T10123 T10121 nmod MTF,gene
R5882 T10124 T10123 punct -,MTF
R5883 T10125 T10123 nummod 1,MTF
R5884 T10126 T10121 compound target,gene
R5885 T10127 T10118 auxpass was,named
R5886 T10128 T10129 nmod N,myc
R5887 T10129 T10131 nmod myc,gene
R5888 T10130 T10129 punct -,myc
R5889 T10131 T10118 oprd gene,named
R5890 T10132 T10133 advmod downstream,regulated
R5891 T10133 T10131 amod regulated,gene
R5892 T10134 T10131 nummod 1,gene
R5893 T10135 T10118 advcl following,named
R5894 T10136 T10137 det the,discovery
R5895 T10137 T10135 dobj discovery,following
R5896 T10138 T10139 mark that,represses
R5897 T10139 T10137 acl represses,discovery
R5898 T10140 T10141 det the,factor
R5899 T10141 T10139 nsubj factor,represses
R5900 T10142 T10141 compound transcription,factor
R5901 T10143 T10144 compound N,myc
R5902 T10144 T10141 appos myc,factor
R5903 T10145 T10144 punct -,myc
R5904 T10146 T10147 det the,expression
R5905 T10147 T10139 dobj expression,represses
R5906 T10148 T10147 prep of,expression
R5907 T10149 T10150 compound mouse,Ndrg1
R5908 T10150 T10148 pobj Ndrg1,of
R5909 T10151 T10152 punct (,51
R5910 T10152 T10118 parataxis 51,named
R5911 T10153 T10152 punct ),51
R5912 T10154 T10118 punct .,named
R5913 T10156 T10157 nsubjpass Transcription,induced
R5914 T10158 T10156 prep of,Transcription
R5915 T10159 T10158 pobj Ndrg1,of
R5916 T10160 T10159 cc and,Ndrg1
R5917 T10161 T10160 punct /,and
R5918 T10162 T10160 cc or,and
R5919 T10163 T10164 poss its,ortholog
R5920 T10164 T10159 conj ortholog,Ndrg1
R5921 T10165 T10164 amod human,ortholog
R5922 T10166 T10157 auxpass is,induced
R5923 T10167 T10157 agent by,induced
R5924 T10168 T10169 amod different,conditions
R5925 T10169 T10167 pobj conditions,by
R5926 T10170 T10169 amod physiological,conditions
R5927 T10171 T10170 cc and,physiological
R5928 T10172 T10173 compound cell,stress
R5929 T10173 T10170 conj stress,physiological
R5930 T10174 T10169 punct ", ",conditions
R5931 T10175 T10176 amod such,as
R5932 T10176 T10169 prep as,conditions
R5933 T10177 T10176 pobj androgens,as
R5934 T10178 T10177 punct ", ",androgens
R5935 T10179 T10180 compound nickel,compounds
R5936 T10180 T10177 conj compounds,androgens
R5937 T10181 T10180 punct ", ",compounds
R5938 T10182 T10180 conj DNA,compounds
R5939 T10183 T10182 nmod damage,DNA
R5940 T10184 T10182 cc and,DNA
R5941 T10185 T10182 conj hypoxia,DNA
R5942 T10186 T10187 punct (,53
R5943 T10187 T10185 parataxis 53,hypoxia
R5944 T10188 T10187 dep 37,53
R5945 T10189 T10190 punct –,40
R5946 T10190 T10188 prep 40,37
R5947 T10191 T10187 punct ",",53
R5948 T10192 T10187 dep 52,53
R5949 T10193 T10187 punct ",",53
R5950 T10194 T10187 punct ),53
R5951 T10195 T10157 punct .,induced
R5952 T10197 T10198 prep In,overexpressed
R5953 T10199 T10197 pobj addition,In
R5954 T10200 T10198 punct ", ",overexpressed
R5955 T10201 T10202 det the,protein
R5956 T10202 T10198 nsubjpass protein,overexpressed
R5957 T10203 T10198 auxpass is,overexpressed
R5958 T10204 T10198 prep in,overexpressed
R5959 T10205 T10206 amod human,cancers
R5960 T10206 T10204 pobj cancers,in
R5961 T10207 T10206 prep of,cancers
R5962 T10208 T10209 amod many,tissues
R5963 T10209 T10207 pobj tissues,of
R5964 T10210 T10209 punct ", ",tissues
R5965 T10211 T10212 amod such,as
R5966 T10212 T10209 prep as,tissues
R5967 T10213 T10212 pobj lung,as
R5968 T10214 T10213 punct ", ",lung
R5969 T10215 T10213 conj liver,lung
R5970 T10216 T10215 punct ", ",liver
R5971 T10217 T10215 conj brain,liver
R5972 T10218 T10217 punct ", ",brain
R5973 T10219 T10217 conj breast,brain
R5974 T10220 T10219 punct ", ",breast
R5975 T10221 T10219 conj kidney,breast
R5976 T10222 T10221 cc and,kidney
R5977 T10223 T10221 conj skin,kidney
R5978 T10224 T10225 punct (,40
R5979 T10225 T10198 parataxis 40,overexpressed
R5980 T10226 T10225 punct ),40
R5981 T10227 T10198 punct .,overexpressed
R5982 T10229 T10230 mark Although,studied
R5983 T10230 T10241 advcl studied,remains
R5984 T10231 T10230 nsubjpass Ndrg1,studied
R5985 T10232 T10231 cc and,Ndrg1
R5986 T10233 T10234 advmod especially,ortholog
R5987 T10234 T10231 conj ortholog,Ndrg1
R5988 T10235 T10234 poss its,ortholog
R5989 T10236 T10234 amod human,ortholog
R5990 T10237 T10230 aux have,studied
R5991 T10238 T10230 auxpass been,studied
R5992 T10239 T10240 advmod quite,intensely
R5993 T10240 T10230 advmod intensely,studied
R5994 T10241 T10245 ccomp remains,suggests
R5995 T10242 T10241 punct ", ",remains
R5996 T10243 T10244 poss its,function
R5997 T10244 T10241 nsubj function,remains
R5998 T10246 T10241 acomp unclear,remains
R5999 T10247 T10245 punct ;,suggests
R6000 T10248 T10245 advmod however,suggests
R6001 T10249 T10245 punct ", ",suggests
R6002 T10250 T10251 det the,induction
R6003 T10251 T10245 nsubj induction,suggests
R6004 T10252 T10251 prep by,induction
R6005 T10253 T10252 pobj stimuli,by
R6006 T10254 T10253 prep like,stimuli
R6007 T10255 T10254 pobj nickel,like
R6008 T10256 T10255 cc and,nickel
R6009 T10257 T10255 conj hypoxia,nickel
R6010 T10258 T10259 det an,involvement
R6011 T10259 T10245 dobj involvement,suggests
R6012 T10260 T10259 prep in,involvement
R6013 T10261 T10262 det the,response
R6014 T10262 T10260 pobj response,in
R6015 T10263 T10262 compound cell,response
R6016 T10264 T10262 compound stress,response
R6017 T10265 T10245 punct .,suggests
R6018 T10267 T10268 predet Such,role
R6019 T10268 T10270 nsubjpass role,endorsed
R6020 T10269 T10268 det a,role
R6021 T10271 T10270 auxpass is,endorsed
R6022 T10272 T10270 advmod strongly,endorsed
R6023 T10273 T10270 agent by,endorsed
R6024 T10274 T10275 poss our,finding
R6025 T10275 T10273 pobj finding,by
R6026 T10276 T10277 mark that,induced
R6027 T10277 T10275 advcl induced,finding
R6028 T10278 T10279 compound Ndrg1,expression
R6029 T10279 T10277 nsubjpass expression,induced
R6030 T10280 T10279 compound gene,expression
R6031 T10281 T10277 auxpass is,induced
R6032 T10282 T10277 advmod also,induced
R6033 T10283 T10277 agent by,induced
R6034 T10284 T10283 pobj cadmium,by
R6035 T10285 T10277 punct ", ",induced
R6036 T10286 T10277 cc and,induced
R6037 T10287 T10288 mark that,plays
R6038 T10288 T10277 conj plays,induced
R6039 T10289 T10288 nsubj MTF,plays
R6040 T10290 T10289 punct -,MTF
R6041 T10291 T10289 nummod 1,MTF
R6042 T10292 T10293 det a,role
R6043 T10293 T10288 dobj role,plays
R6044 T10294 T10293 amod crucial,role
R6045 T10295 T10288 prep in,plays
R6046 T10296 T10297 det this,induction
R6047 T10297 T10295 pobj induction,in
R6048 T10298 T10270 punct .,endorsed