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PMC:1189074 / 5247-5966 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue
T7247 0-8 NN denotes Strategy
T7248 9-12 IN denotes for
T7249 13-23 NN denotes Disruption
T7250 24-26 IN denotes of
T7251 27-30 DT denotes the
T7253 31-36 NN denotes Mouse
T7254 37-42 NN denotes Acadm
T7252 43-47 NN denotes Gene
T7255 47-165 sentence denotes (A) The MCAD IV2 insertion targeting vector with a deleted 1.3-kb region encompassing exon 10 and flanking sequences.
T7256 48-49 -LRB- denotes (
T7257 49-50 LS denotes A
T7259 50-51 -RRB- denotes )
T7260 52-55 DT denotes The
T7261 56-60 NN denotes MCAD
T7263 61-64 NN denotes IV2
T7262 65-74 NN denotes insertion
T7264 75-84 NN denotes targeting
T7258 85-91 NN denotes vector
T7265 92-96 IN denotes with
T7266 97-98 DT denotes a
T7268 99-106 VBN denotes deleted
T7269 107-110 CD denotes 1.3
T7271 110-111 HYPH denotes -
T7270 111-113 NN denotes kb
T7267 114-120 NN denotes region
T7272 121-133 VBG denotes encompassing
T7273 134-138 NN denotes exon
T7274 139-141 CD denotes 10
T7275 142-145 CC denotes and
T7276 146-154 VBG denotes flanking
T7277 155-164 NNS denotes sequences
T7278 164-165 . denotes .
T7279 165-329 sentence denotes MCAD IV2 undergoes gap repair upon homologous recombination at the endogenous Acadm locus resulting in a duplication of exons 8, 9, and 10 at the disrupted allele.
T7280 166-170 NN denotes MCAD
T7281 171-174 NN denotes IV2
T7282 175-184 VBZ denotes undergoes
T7283 185-188 NN denotes gap
T7284 189-195 NN denotes repair
T7285 196-200 IN denotes upon
T7286 201-211 JJ denotes homologous
T7287 212-225 NN denotes recombination
T7288 226-228 IN denotes at
T7289 229-232 DT denotes the
T7291 233-243 JJ denotes endogenous
T7292 244-249 NN denotes Acadm
T7290 250-255 NN denotes locus
T7293 256-265 VBG denotes resulting
T7294 266-268 IN denotes in
T7295 269-270 DT denotes a
T7296 271-282 NN denotes duplication
T7297 283-285 IN denotes of
T7298 286-291 NNS denotes exons
T7299 292-293 CD denotes 8
T7300 293-295 , denotes ,
T7301 295-296 CD denotes 9
T7302 296-298 , denotes ,
T7303 298-301 CC denotes and
T7304 302-304 CD denotes 10
T7305 305-307 IN denotes at
T7306 308-311 DT denotes the
T7308 312-321 VBN denotes disrupted
T7307 322-328 NN denotes allele
T7309 328-329 . denotes .
T7310 329-417 sentence denotes (B) Southern blot analysis of EcoRI-digested genomic DNA from ES cells screened by PCR.
T7311 330-331 -LRB- denotes (
T7312 331-332 LS denotes B
T7314 332-333 -RRB- denotes )
T7315 334-342 NNP denotes Southern
T7316 343-347 NN denotes blot
T7313 348-356 NN denotes analysis
T7317 357-359 IN denotes of
T7318 360-365 NN denotes EcoRI
T7320 365-366 HYPH denotes -
T7319 366-374 VBN denotes digested
T7322 375-382 JJ denotes genomic
T7321 383-386 NN denotes DNA
T7323 387-391 IN denotes from
T7324 392-394 NN denotes ES
T7325 395-400 NNS denotes cells
T7326 401-409 VBN denotes screened
T7327 410-412 IN denotes by
T7328 413-416 NN denotes PCR
T7329 416-417 . denotes .
T7330 417-624 sentence denotes Probe A, a DNA fragment consisting of a portion of exon 10 that is not present in the targeting vector, hybridizes to an endogenous 3.1-kb fragment and, upon homologous recombination, to a 13.2-kb fragment.
T7331 418-423 NN denotes Probe
T7332 424-425 NN denotes A
T7334 425-427 , denotes ,
T7335 427-428 DT denotes a
T7337 429-432 NN denotes DNA
T7336 433-441 NN denotes fragment
T7338 442-452 VBG denotes consisting
T7339 453-455 IN denotes of
T7340 456-457 DT denotes a
T7341 458-465 NN denotes portion
T7342 466-468 IN denotes of
T7343 469-473 NN denotes exon
T7344 474-476 CD denotes 10
T7345 477-481 WDT denotes that
T7346 482-484 VBZ denotes is
T7347 485-488 RB denotes not
T7348 489-496 JJ denotes present
T7349 497-499 IN denotes in
T7350 500-503 DT denotes the
T7352 504-513 NN denotes targeting
T7351 514-520 NN denotes vector
T7353 520-522 , denotes ,
T7333 522-532 VBZ denotes hybridizes
T7354 533-535 IN denotes to
T7355 536-538 DT denotes an
T7357 539-549 JJ denotes endogenous
T7358 550-553 CD denotes 3.1
T7360 553-554 HYPH denotes -
T7359 554-556 NN denotes kb
T7356 557-565 NN denotes fragment
T7361 566-569 CC denotes and
T7362 569-571 , denotes ,
T7363 571-575 IN denotes upon
T7365 576-586 JJ denotes homologous
T7366 587-600 NN denotes recombination
T7367 600-602 , denotes ,
T7364 602-604 IN denotes to
T7368 605-606 DT denotes a
T7370 607-611 CD denotes 13.2
T7372 611-612 HYPH denotes -
T7371 612-614 NN denotes kb
T7369 615-623 NN denotes fragment
T7373 623-624 . denotes .
T7374 624-719 sentence denotes Lane 1 represents a wild-type ES cell line, and Lane 2 and 3 represent targeted ES cell lines.
T7375 625-629 NN denotes Lane
T7377 630-631 CD denotes 1
T7376 632-642 VBZ denotes represents
T7378 643-644 DT denotes a
T7380 645-649 JJ denotes wild
T7382 649-650 HYPH denotes -
T7381 650-654 NN denotes type
T7383 655-657 NN denotes ES
T7384 658-662 NN denotes cell
T7379 663-667 NN denotes line
T7385 667-669 , denotes ,
T7386 669-672 CC denotes and
T7387 673-677 NN denotes Lane
T7388 678-679 CD denotes 2
T7390 680-683 CC denotes and
T7391 684-685 CD denotes 3
T7389 686-695 VBP denotes represent
T7392 696-704 VBN denotes targeted
T7394 705-707 NN denotes ES
T7395 708-712 NN denotes cell
T7393 713-718 NNS denotes lines
T7396 718-719 . denotes .
R4678 T7248 T7247 prep for,Strategy
R4679 T7249 T7248 pobj Disruption,for
R4680 T7250 T7249 prep of,Disruption
R4681 T7251 T7252 det the,Gene
R4682 T7252 T7250 pobj Gene,of
R4683 T7253 T7252 compound Mouse,Gene
R4684 T7254 T7252 compound Acadm,Gene
R4685 T7256 T7257 punct (,A
R4686 T7257 T7258 meta A,vector
R4687 T7259 T7257 punct ),A
R4688 T7260 T7258 det The,vector
R4689 T7261 T7262 compound MCAD,insertion
R4690 T7262 T7258 compound insertion,vector
R4691 T7263 T7262 compound IV2,insertion
R4692 T7264 T7258 compound targeting,vector
R4693 T7265 T7258 prep with,vector
R4694 T7266 T7267 det a,region
R4695 T7267 T7265 pobj region,with
R4696 T7268 T7267 amod deleted,region
R4697 T7269 T7270 nummod 1.3,kb
R4698 T7270 T7267 compound kb,region
R4699 T7271 T7270 punct -,kb
R4700 T7272 T7267 acl encompassing,region
R4701 T7273 T7272 dobj exon,encompassing
R4702 T7274 T7273 nummod 10,exon
R4703 T7275 T7273 cc and,exon
R4704 T7276 T7277 amod flanking,sequences
R4705 T7277 T7273 conj sequences,exon
R4706 T7278 T7258 punct .,vector
R4707 T7280 T7281 compound MCAD,IV2
R4708 T7281 T7282 nsubj IV2,undergoes
R4709 T7283 T7284 compound gap,repair
R4710 T7284 T7282 dobj repair,undergoes
R4711 T7285 T7282 prep upon,undergoes
R4712 T7286 T7287 amod homologous,recombination
R4713 T7287 T7285 pobj recombination,upon
R4714 T7288 T7282 prep at,undergoes
R4715 T7289 T7290 det the,locus
R4716 T7290 T7288 pobj locus,at
R4717 T7291 T7290 amod endogenous,locus
R4718 T7292 T7290 compound Acadm,locus
R4719 T7293 T7282 advcl resulting,undergoes
R4720 T7294 T7293 prep in,resulting
R4721 T7295 T7296 det a,duplication
R4722 T7296 T7294 pobj duplication,in
R4723 T7297 T7296 prep of,duplication
R4724 T7298 T7299 nmod exons,8
R4725 T7299 T7297 pobj 8,of
R4726 T7300 T7299 punct ", ",8
R4727 T7301 T7299 conj 9,8
R4728 T7302 T7301 punct ", ",9
R4729 T7303 T7301 cc and,9
R4730 T7304 T7301 conj 10,9
R4731 T7305 T7296 prep at,duplication
R4732 T7306 T7307 det the,allele
R4733 T7307 T7305 pobj allele,at
R4734 T7308 T7307 amod disrupted,allele
R4735 T7309 T7282 punct .,undergoes
R4736 T7311 T7312 punct (,B
R4737 T7312 T7313 meta B,analysis
R4738 T7314 T7312 punct ),B
R4739 T7315 T7316 compound Southern,blot
R4740 T7316 T7313 compound blot,analysis
R4741 T7317 T7313 prep of,analysis
R4742 T7318 T7319 npadvmod EcoRI,digested
R4743 T7319 T7321 amod digested,DNA
R4744 T7320 T7319 punct -,digested
R4745 T7321 T7317 pobj DNA,of
R4746 T7322 T7321 amod genomic,DNA
R4747 T7323 T7321 prep from,DNA
R4748 T7324 T7325 compound ES,cells
R4749 T7325 T7323 pobj cells,from
R4750 T7326 T7325 acl screened,cells
R4751 T7327 T7326 prep by,screened
R4752 T7328 T7327 pobj PCR,by
R4753 T7329 T7313 punct .,analysis
R4754 T7331 T7332 compound Probe,A
R4755 T7332 T7333 nsubj A,hybridizes
R4756 T7334 T7332 punct ", ",A
R4757 T7335 T7336 det a,fragment
R4758 T7336 T7332 appos fragment,A
R4759 T7337 T7336 compound DNA,fragment
R4760 T7338 T7336 acl consisting,fragment
R4761 T7339 T7338 prep of,consisting
R4762 T7340 T7341 det a,portion
R4763 T7341 T7339 pobj portion,of
R4764 T7342 T7341 prep of,portion
R4765 T7343 T7342 pobj exon,of
R4766 T7344 T7343 nummod 10,exon
R4767 T7345 T7346 dep that,is
R4768 T7346 T7341 relcl is,portion
R4769 T7347 T7346 neg not,is
R4770 T7348 T7346 acomp present,is
R4771 T7349 T7346 prep in,is
R4772 T7350 T7351 det the,vector
R4773 T7351 T7349 pobj vector,in
R4774 T7352 T7351 compound targeting,vector
R4775 T7353 T7333 punct ", ",hybridizes
R4776 T7354 T7333 prep to,hybridizes
R4777 T7355 T7356 det an,fragment
R4778 T7356 T7354 pobj fragment,to
R4779 T7357 T7356 amod endogenous,fragment
R4780 T7358 T7359 nummod 3.1,kb
R4781 T7359 T7356 compound kb,fragment
R4782 T7360 T7359 punct -,kb
R4783 T7361 T7333 cc and,hybridizes
R4784 T7362 T7333 punct ", ",hybridizes
R4785 T7363 T7364 prep upon,to
R4786 T7364 T7333 conj to,hybridizes
R4787 T7365 T7366 amod homologous,recombination
R4788 T7366 T7363 pobj recombination,upon
R4789 T7367 T7364 punct ", ",to
R4790 T7368 T7369 det a,fragment
R4791 T7369 T7364 pobj fragment,to
R4792 T7370 T7371 nummod 13.2,kb
R4793 T7371 T7369 compound kb,fragment
R4794 T7372 T7371 punct -,kb
R4795 T7373 T7333 punct .,hybridizes
R4796 T7375 T7376 nsubj Lane,represents
R4797 T7377 T7375 nummod 1,Lane
R4798 T7378 T7379 det a,line
R4799 T7379 T7376 dobj line,represents
R4800 T7380 T7381 amod wild,type
R4801 T7381 T7379 compound type,line
R4802 T7382 T7381 punct -,type
R4803 T7383 T7379 compound ES,line
R4804 T7384 T7379 compound cell,line
R4805 T7385 T7376 punct ", ",represents
R4806 T7386 T7376 cc and,represents
R4807 T7387 T7388 nmod Lane,2
R4808 T7388 T7389 nsubj 2,represent
R4809 T7389 T7376 conj represent,represents
R4810 T7390 T7388 cc and,2
R4811 T7391 T7388 conj 3,2
R4812 T7392 T7393 amod targeted,lines
R4813 T7393 T7389 dobj lines,represent
R4814 T7394 T7393 compound ES,lines
R4815 T7395 T7393 compound cell,lines
R4816 T7396 T7389 punct .,represent