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PMC:1084331 / 13242-14058 JSONTXT 6 Projects

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Id Subject Object Predicate Lexical cue
T5269 0-2 TO denotes To
T5270 3-10 VB denotes address
T5272 11-14 DT denotes the
T5273 15-27 NNS denotes consequences
T5274 28-30 IN denotes of
T5275 31-41 JJ denotes precocious
T5277 42-45 NN denotes ETS
T5276 46-55 NN denotes signaling
T5278 56-59 IN denotes for
T5279 60-74 JJ denotes proprioceptive
T5280 75-83 JJ denotes afferent
T5281 84-99 NN denotes differentiation
T5282 99-101 , denotes ,
T5283 101-103 PRP denotes we
T5284 104-108 RB denotes next
T5271 109-118 VBD denotes expressed
T5285 119-122 NN denotes EWS
T5287 122-123 HYPH denotes -
T5286 123-127 NN denotes Pea3
T5288 128-130 IN denotes in
T5289 131-134 NN denotes DRG
T5290 135-142 NNS denotes neurons
T5291 143-145 RB denotes as
T5292 146-150 RB denotes soon
T5293 151-153 IN denotes as
T5295 154-158 PRP denotes they
T5294 159-165 VBD denotes became
T5296 166-178 JJ denotes post-mitotic
T5297 178-179 . denotes .
T5298 179-318 sentence denotes We used a binary mouse genetic system based on Cre-recombinase-mediated excision of a transcriptional stop cassette flanked by loxP sites.
T5299 180-182 PRP denotes We
T5300 183-187 VBD denotes used
T5301 188-189 DT denotes a
T5303 190-196 JJ denotes binary
T5304 197-202 NN denotes mouse
T5305 203-210 JJ denotes genetic
T5302 211-217 NN denotes system
T5306 218-223 VBN denotes based
T5307 224-226 IN denotes on
T5308 227-230 NN denotes Cre
T5310 230-231 HYPH denotes -
T5309 231-242 NN denotes recombinase
T5312 242-243 HYPH denotes -
T5311 243-251 VBN denotes mediated
T5313 252-260 NN denotes excision
T5314 261-263 IN denotes of
T5315 264-265 DT denotes a
T5317 266-281 JJ denotes transcriptional
T5318 282-286 NN denotes stop
T5316 287-295 NN denotes cassette
T5319 296-303 VBN denotes flanked
T5320 304-306 IN denotes by
T5321 307-311 NN denotes loxP
T5322 312-317 NNS denotes sites
T5323 317-318 . denotes .
T5324 318-564 sentence denotes Targeting cassettes were integrated into the Tau locus to generate two strains of mice conditionally expressing either EWS-Pea3 or a membrane-targeted green fluorescent protein (mGFP) to trace axonal projections of DRG neurons (Figure S3; [25]).
T5325 319-328 NN denotes Targeting
T5326 329-338 NNS denotes cassettes
T5328 339-343 VBD denotes were
T5327 344-354 VBN denotes integrated
T5329 355-359 IN denotes into
T5330 360-363 DT denotes the
T5332 364-367 NN denotes Tau
T5331 368-373 NN denotes locus
T5333 374-376 TO denotes to
T5334 377-385 VB denotes generate
T5335 386-389 CD denotes two
T5336 390-397 NNS denotes strains
T5337 398-400 IN denotes of
T5338 401-405 NNS denotes mice
T5339 406-419 RB denotes conditionally
T5340 420-430 VBG denotes expressing
T5341 431-437 CC denotes either
T5343 438-441 NN denotes EWS
T5344 441-442 HYPH denotes -
T5342 442-446 NN denotes Pea3
T5345 447-449 CC denotes or
T5346 450-451 DT denotes a
T5348 452-460 NN denotes membrane
T5350 460-461 HYPH denotes -
T5349 461-469 JJ denotes targeted
T5351 470-475 JJ denotes green
T5352 476-487 JJ denotes fluorescent
T5347 488-495 NN denotes protein
T5353 496-497 -LRB- denotes (
T5354 497-501 NN denotes mGFP
T5355 501-502 -RRB- denotes )
T5356 503-505 TO denotes to
T5357 506-511 VB denotes trace
T5358 512-518 JJ denotes axonal
T5359 519-530 NNS denotes projections
T5360 531-533 IN denotes of
T5361 534-537 NN denotes DRG
T5362 538-545 NNS denotes neurons
T5363 546-547 -LRB- denotes (
T5365 547-553 NN denotes Figure
T5366 554-556 NN denotes S3
T5367 556-557 : denotes ;
T5368 558-559 -LRB- denotes [
T5364 559-561 CD denotes 25
T5369 561-562 -RRB- denotes ]
T5370 562-563 -RRB- denotes )
T5371 563-564 . denotes .
T5372 564-816 sentence denotes Embryos positive for either Isl1Cre/+ and TauEWS-Pea3/+ or Isl1Cre/+ and TaumGFP/+ alleles showed efficient activation of the silent Tau allele in 95% or more of all DRG neurons, including proprioceptive afferents, at all segmental levels (Figure S3).
T5373 565-572 NNS denotes Embryos
T5375 573-581 JJ denotes positive
T5376 582-585 IN denotes for
T5377 586-592 CC denotes either
T5378 593-600 NN denotes Isl1Cre
T5380 600-601 HYPH denotes /
T5381 601-602 SYM denotes +
T5382 603-606 CC denotes and
T5383 607-613 NN denotes TauEWS
T5385 613-614 HYPH denotes -
T5384 614-618 NN denotes Pea3
T5386 618-619 HYPH denotes /
T5387 619-620 SYM denotes +
T5388 621-623 CC denotes or
T5389 624-631 NN denotes Isl1Cre
T5390 631-632 HYPH denotes /
T5391 632-633 SYM denotes +
T5392 634-637 CC denotes and
T5393 638-645 NN denotes TaumGFP
T5394 645-646 HYPH denotes /
T5395 646-647 SYM denotes +
T5379 648-655 NNS denotes alleles
T5374 656-662 VBD denotes showed
T5396 663-672 JJ denotes efficient
T5397 673-683 NN denotes activation
T5398 684-686 IN denotes of
T5399 687-690 DT denotes the
T5401 691-697 JJ denotes silent
T5402 698-701 NN denotes Tau
T5400 702-708 NN denotes allele
T5403 709-711 IN denotes in
T5404 712-714 CD denotes 95
T5405 714-715 NN denotes %
T5406 716-718 CC denotes or
T5407 719-723 JJR denotes more
T5408 724-726 IN denotes of
T5409 727-730 DT denotes all
T5411 731-734 NN denotes DRG
T5410 735-742 NNS denotes neurons
T5412 742-744 , denotes ,
T5413 744-753 VBG denotes including
T5414 754-768 JJ denotes proprioceptive
T5415 769-778 NNS denotes afferents
T5416 778-780 , denotes ,
T5417 780-782 IN denotes at
T5418 783-786 DT denotes all
T5420 787-796 JJ denotes segmental
T5419 797-803 NNS denotes levels
T5421 804-805 -LRB- denotes (
T5423 805-811 NN denotes Figure
T5422 812-814 NN denotes S3
T5424 814-815 -RRB- denotes )
T5425 815-816 . denotes .
R1810 T5269 T5270 aux To,address
R1811 T5270 T5271 advcl address,expressed
R1812 T5272 T5273 det the,consequences
R1813 T5273 T5270 dobj consequences,address
R1814 T5274 T5273 prep of,consequences
R1815 T5275 T5276 amod precocious,signaling
R1816 T5276 T5274 pobj signaling,of
R1817 T5277 T5276 compound ETS,signaling
R1818 T5278 T5273 prep for,consequences
R1819 T5279 T5280 amod proprioceptive,afferent
R1820 T5280 T5281 nmod afferent,differentiation
R1821 T5281 T5278 pobj differentiation,for
R1822 T5282 T5271 punct ", ",expressed
R1823 T5283 T5271 nsubj we,expressed
R1824 T5284 T5271 advmod next,expressed
R1825 T5285 T5286 compound EWS,Pea3
R1826 T5286 T5271 dobj Pea3,expressed
R1827 T5287 T5286 punct -,Pea3
R1828 T5288 T5271 prep in,expressed
R1829 T5289 T5290 compound DRG,neurons
R1830 T5290 T5288 pobj neurons,in
R1831 T5291 T5292 advmod as,soon
R1832 T5292 T5271 advmod soon,expressed
R1833 T5293 T5294 mark as,became
R1834 T5294 T5292 advcl became,soon
R1835 T5295 T5294 nsubj they,became
R1836 T5296 T5294 acomp post-mitotic,became
R1837 T5297 T5271 punct .,expressed
R1838 T5299 T5300 nsubj We,used
R1839 T5301 T5302 det a,system
R1840 T5302 T5300 dobj system,used
R1841 T5303 T5302 amod binary,system
R1842 T5304 T5302 nmod mouse,system
R1843 T5305 T5302 amod genetic,system
R1844 T5306 T5302 prep based,system
R1845 T5307 T5306 prep on,based
R1846 T5308 T5309 compound Cre,recombinase
R1847 T5309 T5311 npadvmod recombinase,mediated
R1848 T5310 T5309 punct -,recombinase
R1849 T5311 T5313 amod mediated,excision
R1850 T5312 T5311 punct -,mediated
R1851 T5313 T5307 pobj excision,on
R1852 T5314 T5313 prep of,excision
R1853 T5315 T5316 det a,cassette
R1854 T5316 T5314 pobj cassette,of
R1855 T5317 T5316 amod transcriptional,cassette
R1856 T5318 T5316 compound stop,cassette
R1857 T5319 T5316 acl flanked,cassette
R1858 T5320 T5319 agent by,flanked
R1859 T5321 T5322 compound loxP,sites
R1860 T5322 T5320 pobj sites,by
R1861 T5323 T5300 punct .,used
R1862 T5325 T5326 compound Targeting,cassettes
R1863 T5326 T5327 nsubjpass cassettes,integrated
R1864 T5328 T5327 auxpass were,integrated
R1865 T5329 T5327 prep into,integrated
R1866 T5330 T5331 det the,locus
R1867 T5331 T5329 pobj locus,into
R1868 T5332 T5331 compound Tau,locus
R1869 T5333 T5334 aux to,generate
R1870 T5334 T5327 advcl generate,integrated
R1871 T5335 T5336 nummod two,strains
R1872 T5336 T5334 dobj strains,generate
R1873 T5337 T5336 prep of,strains
R1874 T5338 T5337 pobj mice,of
R1875 T5339 T5340 advmod conditionally,expressing
R1876 T5340 T5336 acl expressing,strains
R1877 T5341 T5342 preconj either,Pea3
R1878 T5342 T5340 dobj Pea3,expressing
R1879 T5343 T5342 compound EWS,Pea3
R1880 T5344 T5342 punct -,Pea3
R1881 T5345 T5342 cc or,Pea3
R1882 T5346 T5347 det a,protein
R1883 T5347 T5342 conj protein,Pea3
R1884 T5348 T5349 npadvmod membrane,targeted
R1885 T5349 T5347 amod targeted,protein
R1886 T5350 T5349 punct -,targeted
R1887 T5351 T5347 amod green,protein
R1888 T5352 T5347 amod fluorescent,protein
R1889 T5353 T5347 punct (,protein
R1890 T5354 T5347 appos mGFP,protein
R1891 T5355 T5347 punct ),protein
R1892 T5356 T5357 aux to,trace
R1893 T5357 T5340 advcl trace,expressing
R1894 T5358 T5359 amod axonal,projections
R1895 T5359 T5357 dobj projections,trace
R1896 T5360 T5359 prep of,projections
R1897 T5361 T5362 compound DRG,neurons
R1898 T5362 T5360 pobj neurons,of
R1899 T5363 T5364 punct (,25
R1900 T5364 T5334 parataxis 25,generate
R1901 T5365 T5366 compound Figure,S3
R1902 T5366 T5364 dep S3,25
R1903 T5367 T5364 punct ;,25
R1904 T5368 T5364 punct [,25
R1905 T5369 T5364 punct ],25
R1906 T5370 T5364 punct ),25
R1907 T5371 T5327 punct .,integrated
R1908 T5373 T5374 nsubj Embryos,showed
R1909 T5375 T5373 amod positive,Embryos
R1910 T5376 T5375 prep for,positive
R1911 T5377 T5378 preconj either,Isl1Cre
R1912 T5378 T5379 nmod Isl1Cre,alleles
R1913 T5379 T5376 pobj alleles,for
R1914 T5380 T5378 punct /,Isl1Cre
R1915 T5381 T5378 punct +,Isl1Cre
R1916 T5382 T5378 cc and,Isl1Cre
R1917 T5383 T5384 compound TauEWS,Pea3
R1918 T5384 T5378 conj Pea3,Isl1Cre
R1919 T5385 T5384 punct -,Pea3
R1920 T5386 T5384 punct /,Pea3
R1921 T5387 T5384 punct +,Pea3
R1922 T5388 T5378 cc or,Isl1Cre
R1923 T5389 T5378 conj Isl1Cre,Isl1Cre
R1924 T5390 T5389 punct /,Isl1Cre
R1925 T5391 T5389 punct +,Isl1Cre
R1926 T5392 T5389 cc and,Isl1Cre
R1927 T5393 T5389 conj TaumGFP,Isl1Cre
R1928 T5394 T5393 punct /,TaumGFP
R1929 T5395 T5393 punct +,TaumGFP
R1930 T5396 T5397 amod efficient,activation
R1931 T5397 T5374 dobj activation,showed
R1932 T5398 T5397 prep of,activation
R1933 T5399 T5400 det the,allele
R1934 T5400 T5398 pobj allele,of
R1935 T5401 T5400 amod silent,allele
R1936 T5402 T5400 compound Tau,allele
R1937 T5403 T5374 prep in,showed
R1938 T5404 T5405 nummod 95,%
R1939 T5405 T5403 pobj %,in
R1940 T5406 T5407 cc or,more
R1941 T5407 T5405 nummod more,%
R1942 T5408 T5405 prep of,%
R1943 T5409 T5410 det all,neurons
R1944 T5410 T5408 pobj neurons,of
R1945 T5411 T5410 compound DRG,neurons
R1946 T5412 T5405 punct ", ",%
R1947 T5413 T5405 prep including,%
R1948 T5414 T5415 amod proprioceptive,afferents
R1949 T5415 T5413 pobj afferents,including
R1950 T5416 T5374 punct ", ",showed
R1951 T5417 T5374 prep at,showed
R1952 T5418 T5419 det all,levels
R1953 T5419 T5417 pobj levels,at
R1954 T5420 T5419 amod segmental,levels
R1955 T5421 T5422 punct (,S3
R1956 T5422 T5374 parataxis S3,showed
R1957 T5423 T5422 compound Figure,S3
R1958 T5424 T5422 punct ),S3
R1959 T5425 T5374 punct .,showed