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PMC:3359311 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue
T802 288-306 Protein denotes Interleukin-1 beta
T803 308-313 Protein denotes IL-1β
T804 337-345 Positive_regulation denotes mediator
T805 337-345 Positive_regulation denotes mediator
T807 347-356 Localization denotes Secretion
T806 380-385 Protein denotes IL-1β
T808 471-476 Protein denotes IL-1β
T811 707-714 Gene_expression denotes produce
T809 757-762 Protein denotes IL-1β
T812 826-836 Positive_regulation denotes upregulate
T810 837-846 Protein denotes caspase-1
T815 985-993 Gene_expression denotes produced
T817 1000-1007 Positive_regulation denotes amounts
T813 1011-1016 Protein denotes IL-1β
T816 1030-1041 Positive_regulation denotes upregulated
T814 1042-1051 Protein denotes caspase-1
T818 1156-1165 Protein denotes caspase-1
T820 1166-1176 Positive_regulation denotes activation
T822 1166-1176 Positive_regulation denotes activation
T819 1181-1186 Protein denotes IL-1β
T821 1187-1197 Gene_expression denotes production
T823 1249-1254 Protein denotes IL-1β
T825 1255-1265 Gene_expression denotes production
T826 1270-1279 Positive_regulation denotes dependent
T824 1283-1288 Protein denotes NF-κB
T827 1311-1319 Positive_regulation denotes enhanced
T831 1359-1369 Negative_regulation denotes inhibition
T828 1373-1377 Protein denotes CFTR
T834 1442-1447 Positive_regulation denotes alter
T835 1442-1447 Positive_regulation denotes alter
T829 1448-1453 Protein denotes IL-1β
T830 1457-1461 Protein denotes IL-8
T832 1462-1472 Gene_expression denotes production
T833 1462-1472 Gene_expression denotes production
T836 1612-1617 Protein denotes IL-1β
T837 1702-1707 Protein denotes IL-1β
T839 1708-1717 Localization denotes secretion
T840 1708-1717 Localization denotes secretion
T838 1743-1777 Protein denotes CF pathogen Pseudomonas aeruginosa
T848 1832-1841 Positive_regulation denotes increased
T841 1842-1847 Protein denotes IL-1β
T844 1848-1858 Gene_expression denotes production
T845 1877-1880 Positive_regulation denotes due
T846 1897-1905 Positive_regulation denotes increase
T842 1909-1914 Protein denotes NF-κB
T847 1932-1936 Negative_regulation denotes loss
T843 1940-1944 Protein denotes CFTR
T2513 2047-2098 Protein denotes cystic fibrosis transmembrane conductance regulator
T2514 2100-2104 Protein denotes CFTR
T2516 2831-2838 Negative_regulation denotes lacking
T2515 2839-2843 Protein denotes CFTR
T2517 3138-3156 Protein denotes Interleukin-1 beta
T2518 3158-3163 Protein denotes IL-1β
T2519 3189-3197 Positive_regulation denotes mediator
T2520 3189-3197 Positive_regulation denotes mediator
T2523 3399-3408 Positive_regulation denotes induction
T2524 3399-3408 Positive_regulation denotes induction
T2521 3453-3457 Protein denotes IL-6
T2522 3462-3466 Protein denotes IL-8
T2525 3543-3548 Protein denotes NF-κB
T2526 3568-3573 Protein denotes IL-1β
T2527 3577-3585 Gene_expression denotes produced
T2528 3907-3912 Protein denotes IL-1β
T2529 3917-3926 Protein denotes pro-IL-18
T2530 3968-3977 Localization denotes secretion
T2531 3968-3977 Localization denotes secretion
T2532 4043-4060 Protein denotes NLRP1 [12], NLRP3
T2536 4389-4397 Positive_regulation denotes increase
T2537 4389-4397 Positive_regulation denotes increase
T2538 4389-4397 Positive_regulation denotes increase
T2533 4411-4416 Protein denotes IL-1β
T2534 4418-4422 Protein denotes IL-6
T2535 4428-4432 Protein denotes IL-8
T2539 4533-4538 Protein denotes NF-κB
T2540 4556-4561 Protein denotes NF-κB
T2543 4587-4599 Positive_regulation denotes upregulation
T2541 4659-4664 Protein denotes IL-1β
T2542 4665-4675 Gene_expression denotes expression
T2544 4724-4729 Protein denotes IL-1β
T2545 4793-4798 Protein denotes IL-1β
T2546 4803-4812 Positive_regulation denotes increased
T2547 4990-4999 Protein denotes IL1B gene
T2548 5105-5109 Protein denotes CFTR
T2555 5149-5158 Positive_regulation denotes increases
T2549 5162-5167 Protein denotes IL-1β
T2552 5168-5178 Gene_expression denotes expression
T2553 5255-5259 Negative_regulation denotes loss
T2550 5263-5267 Protein denotes CFTR
T2556 5268-5277 Positive_regulation denotes increases
T2551 5278-5283 Protein denotes NF-κB
T2554 5284-5294 Positive_regulation denotes activation
T2562 5444-5453 Positive_regulation denotes increases
T2560 5454-5463 Localization denotes secretion
T2557 5467-5472 Protein denotes IL-1β
T2558 5488-5493 Protein denotes NLRP3
T2559 5602-5607 Protein denotes NLRP3
T2561 5608-5618 Positive_regulation denotes activation
T2563 5676-5681 Protein denotes IL-1β
T3058 5788-5795 Gene_expression denotes produce
T3057 5819-5824 Protein denotes IL-1β
T3063 6247-6256 Positive_regulation denotes increased
T3059 6257-6262 Protein denotes IL-1β
T3062 6263-6273 Gene_expression denotes production
T3060 6380-6414 Protein denotes inducers P. aeruginosa strain PAO1
T3061 6416-6420 Protein denotes PAO1
T3064 6447-6452 Protein denotes IL-1β
T3066 6506-6515 Positive_regulation denotes increased
T3068 6585-6593 Positive_regulation denotes increase
T3065 6597-6602 Protein denotes IL-1β
T3067 6603-6613 Gene_expression denotes production
T3069 6793-6810 Protein denotes recombinant IL-1β
T3072 6812-6821 Gene_expression denotes producing
T3073 6812-6821 Gene_expression denotes producing
T3070 6842-6846 Protein denotes IL-8
T3071 6848-6851 Protein denotes Fig
T12782 7068-7082 Protein denotes THP-1 reporter
T13106 7338-7343 Protein denotes IL-1β
T13107 7344-7354 Gene_expression denotes production
T13108 7566-7571 Protein denotes IL-1β
T13109 7753-7758 Protein denotes IL-1β
T13110 7763-7767 Protein denotes IL-8
T13111 7768-7778 Gene_expression denotes production
T13112 7768-7778 Gene_expression denotes production
T13113 7849-7854 Protein denotes IL-1β
T3379 7981-7991 Positive_regulation denotes upregulate
T3378 7992-8001 Protein denotes caspase-1
T3380 8119-8128 Protein denotes caspase-1
T3391 8326-8330 Regulation denotes role
T3381 8335-8344 Protein denotes caspase-1
T3388 8352-8362 Positive_regulation denotes activation
T3382 8366-8371 Protein denotes NF-κB
T3383 8380-8398 Protein denotes Toll-like receptor
T3384 8400-8403 Protein denotes TLR
T3389 8450-8460 Negative_regulation denotes inhibition
T3385 8464-8473 Protein denotes caspase-1
T3392 8474-8481 Positive_regulation denotes altered
T3386 8482-8487 Protein denotes NF-κB
T3393 8488-8497 Positive_regulation denotes dependent
T3387 8498-8502 Protein denotes IL-6
T3390 8503-8513 Gene_expression denotes production
T3394 8572-8581 Protein denotes caspase-1
T3398 8618-8626 Negative_regulation denotes decrease
T3395 8627-8631 Protein denotes IL-6
T3397 8632-8641 Localization denotes secretion
T3396 8670-8677 Protein denotes Fig. 3c
T13404 8753-8763 Positive_regulation denotes upregulate
T13403 8764-8773 Protein denotes caspase-1
T13405 9401-9405 Protein denotes IL-6
T3572 9425-9429 Protein denotes CD14
T3574 9492-9501 Positive_regulation denotes increases
T3573 9505-9514 Protein denotes caspase-1
T3575 9606-9610 Protein denotes CD14
T3576 9636-9640 Protein denotes CD14
T3582 9719-9727 Positive_regulation denotes increase
T3577 9731-9740 Protein denotes caspase-1
T3581 9741-9751 Positive_regulation denotes activation
T3578 9783-9787 Protein denotes PAO1
T3579 9810-9817 Protein denotes Fig. 4a
T3580 9890-9897 Protein denotes Fig. 4b
T13624 9993-10002 Positive_regulation denotes increases
T13623 10006-10015 Protein denotes caspase-1
T4280 10456-10463 Gene_expression denotes produce
T4281 10464-10473 Positive_regulation denotes increased
T4279 10485-10490 Protein denotes IL-1β
T4283 10582-10591 Positive_regulation denotes increased
T4285 10582-10591 Positive_regulation denotes increased
T4282 10592-10597 Protein denotes NF-κB
T4284 10637-10646 Localization denotes secretion
T4286 10784-10788 Protein denotes PAO1
T4289 10823-10831 Positive_regulation denotes activate
T4290 10823-10831 Positive_regulation denotes activate
T4287 10836-10841 Protein denotes NLRC4
T4288 10843-10848 Protein denotes NLRP3
T4295 10933-10940 Gene_expression denotes produce
T4296 10933-10940 Gene_expression denotes produce
T4297 10933-10940 Gene_expression denotes produce
T4298 10933-10940 Gene_expression denotes produce
T4299 10941-10950 Positive_regulation denotes increased
T4300 10941-10950 Positive_regulation denotes increased
T4301 10941-10950 Positive_regulation denotes increased
T4302 10941-10950 Positive_regulation denotes increased
T4291 10962-10967 Protein denotes IL-1β
T4292 10969-10976 Protein denotes Fig. 5a
T4293 10981-10985 Protein denotes IL-8
T4294 10987-10994 Protein denotes Fig. 5b
T4303 11102-11107 Protein denotes IL-1β
T4304 11108-11116 Gene_expression denotes produced
T4309 11226-11231 Negative_regulation denotes lacks
T4310 11226-11231 Negative_regulation denotes lacks
T4305 11232-11236 Protein denotes exsA
T4306 11238-11247 Protein denotes PAO1ΔexsA
T4311 11289-11297 Gene_expression denotes produced
T4307 11314-11319 Protein denotes IL-1β
T4308 11345-11349 Protein denotes PAO1
T4314 11429-11435 Positive_regulation denotes result
T4312 11443-11448 Protein denotes IL-1β
T4313 11449-11459 Gene_expression denotes production
T4320 11585-11594 Positive_regulation denotes increased
T4321 11585-11594 Positive_regulation denotes increased
T4318 11595-11605 Gene_expression denotes production
T4319 11595-11605 Gene_expression denotes production
T4315 11609-11614 Protein denotes IL-1β
T4316 11618-11622 Protein denotes IL-8
T4317 11703-11708 Protein denotes NF-κB
T4322 11774-11783 Protein denotes caspase-1
T13903 11923-11930 Gene_expression denotes produce
T13904 11931-11940 Positive_regulation denotes increased
T13902 11952-11957 Protein denotes IL-1β
T13905 12122-12137 Protein denotes aeruginosa PAO1
T13907 12138-12145 Negative_regulation denotes lacking
T13908 12138-12145 Negative_regulation denotes lacking
T13906 12146-12150 Protein denotes exsA
T13910 12227-12234 Negative_regulation denotes lacking
T13909 12235-12239 Protein denotes exsA
T5117 12380-12385 Protein denotes NF-κB
T5120 12386-12396 Positive_regulation denotes activation
T5118 12413-12418 Protein denotes IL-1β
T5119 12423-12427 Protein denotes IL-8
T5121 12428-12437 Regulation denotes responses
T5122 12428-12437 Regulation denotes responses
T5133 12473-12483 Positive_regulation denotes dependence
T5134 12473-12483 Positive_regulation denotes dependence
T5135 12473-12483 Positive_regulation denotes dependence
T5136 12473-12483 Positive_regulation denotes dependence
T5123 12487-12491 Protein denotes PAO1
T5129 12492-12499 Positive_regulation denotes induced
T5137 12492-12499 Positive_regulation denotes induced
T5138 12492-12499 Positive_regulation denotes induced
T5124 12500-12505 Protein denotes IL-1β
T5125 12510-12514 Protein denotes IL-8
T5130 12515-12525 Gene_expression denotes production
T5131 12515-12525 Gene_expression denotes production
T5126 12529-12534 Protein denotes NF-κB
T5132 12535-12545 Positive_regulation denotes activation
T5127 12596-12601 Protein denotes NF-κB
T5128 12606-12628 Protein denotes AP-1 response elements
T5139 12704-12708 Protein denotes PAO1
T5147 12709-12717 Gene_expression denotes produced
T5148 12709-12717 Gene_expression denotes produced
T5140 12740-12745 Protein denotes NF-κB
T5141 12746-12750 Protein denotes AP-1
T5149 12751-12761 Positive_regulation denotes activation
T5150 12751-12761 Positive_regulation denotes activation
T5142 12763-12770 Protein denotes Fig. 6a
T5143 12797-12811 Protein denotes IL-8 secretion
T5144 12813-12820 Protein denotes Fig. 6b
T5151 12837-12844 Positive_regulation denotes amounts
T5145 12848-12853 Protein denotes IL-1β
T5152 12859-12867 Localization denotes secreted
T5146 12869-12876 Protein denotes Fig. 6c
T5153 12932-12936 Protein denotes PAO1
T5159 12959-12967 Positive_regulation denotes increase
T5160 12959-12967 Positive_regulation denotes increase
T5161 12959-12967 Positive_regulation denotes increase
T5162 12959-12967 Positive_regulation denotes increase
T5154 12968-12973 Protein denotes NF-κB
T5155 12974-12978 Protein denotes AP-1
T5156 12989-12996 Protein denotes Fig. 6a
T5157 13001-13015 Protein denotes IL-8 secretion
T5158 13017-13024 Protein denotes Fig. 6b
T5163 13055-13060 Protein denotes IL-1β
T5167 13061-13071 Gene_expression denotes production
T5168 13084-13093 Positive_regulation denotes augmented
T5164 13140-13144 Protein denotes PAO1
T5165 13184-13188 Protein denotes PAO1
T5166 13190-13197 Protein denotes Fig. 6c
T5169 13220-13225 Protein denotes NF-κB
T5173 13226-13236 Positive_regulation denotes activation
T5170 13273-13278 Protein denotes IL-1β
T5174 13279-13288 Localization denotes secretion
T5171 13315-13320 Protein denotes NF-κB
T5176 13335-13345 Positive_regulation denotes augmenting
T5172 13346-13351 Protein denotes IL-1β
T5175 13352-13362 Gene_expression denotes production
T5177 13441-13446 Protein denotes NF-κB
T5184 13478-13488 Negative_regulation denotes inhibition
T5178 13492-13497 Protein denotes NF-κB
T5187 13519-13528 Negative_regulation denotes inhibitor
T5179 13532-13536 Protein denotes IκBα
T5185 13537-13552 Phosphorylation denotes phosphorylation
T5190 13574-13581 Negative_regulation denotes reduced
T5180 13582-13587 Protein denotes NF-κB
T5181 13588-13592 Protein denotes AP-1
T5188 13593-13603 Positive_regulation denotes activation
T5189 13632-13642 Positive_regulation denotes subsequent
T5186 13643-13653 Gene_expression denotes production
T5182 13685-13690 Protein denotes IL-1β
T5183 13752-13756 Protein denotes PAO1
T5191 13904-13909 Protein denotes NF-κB
T5198 13926-13935 Positive_regulation denotes modulator
T5192 13939-13944 Protein denotes IL-1β
T5195 13945-13955 Gene_expression denotes production
T5199 13965-13974 Positive_regulation denotes increased
T5196 13975-13985 Positive_regulation denotes activation
T5193 13989-13994 Protein denotes NF-κB
T5200 13995-14003 Positive_regulation denotes augments
T5197 14026-14036 Gene_expression denotes production
T5194 14040-14045 Protein denotes IL-1β
T14485 14091-14096 Protein denotes NF-κB
T14487 14097-14107 Positive_regulation denotes activation
T14490 14108-14119 Positive_regulation denotes potentiates
T14489 14124-14130 Negative_regulation denotes degree
T14486 14134-14139 Protein denotes IL-1β
T14488 14140-14150 Gene_expression denotes production
T14491 14436-14438 Protein denotes κB
T14492 14439-14443 Protein denotes AP-1
T14493 14649-14653 Protein denotes PAO1
T14494 14662-14666 Protein denotes PAO1
T14495 14717-14719 Protein denotes κB
T14496 14720-14724 Protein denotes AP-1
T14497 14753-14758 Protein denotes IL-1β
T14498 14759-14768 Localization denotes secretion
T14499 14759-14768 Localization denotes secretion
T14500 14924-14928 Protein denotes PAO1
T14501 15020-15025 Protein denotes IL-1β
T5459 15316-15326 Negative_regulation denotes inhibition
T5457 15330-15335 Protein denotes NF-κB
T5460 15375-15382 Negative_regulation denotes inhibit
T5458 15387-15405 Protein denotes NLRP3 inflammasome
T5461 15452-15457 Protein denotes NF-κB
T5466 15458-15467 Negative_regulation denotes inhibitor
T5467 15522-15532 Negative_regulation denotes inhibition
T5462 15536-15540 Protein denotes CFTR
T5463 15553-15563 Protein denotes CFTRinh172
T5464 15579-15583 Protein denotes PAO1
T5465 15614-15621 Protein denotes Fig. 7a
T5473 15800-15807 Negative_regulation denotes inhibit
T5474 15800-15807 Negative_regulation denotes inhibit
T5468 15808-15812 Protein denotes IκBα
T5471 15813-15824 Protein_catabolism denotes degradation
T5469 15855-15859 Protein denotes PAO1
T5472 15860-15871 Positive_regulation denotes stimulation
T5470 15873-15880 Protein denotes Fig. 7b
T14651 16178-16182 Protein denotes PAO1
T5825 16297-16307 Negative_regulation denotes Disruption
T5823 16311-16315 Protein denotes CFTR
T5827 16334-16342 Positive_regulation denotes increase
T5824 16343-16348 Protein denotes IL-1β
T5826 16349-16359 Gene_expression denotes production
T5828 16472-16490 Protein denotes NLRP3 inflammasome
T5829 16529-16533 Protein denotes CFTR
T5832 16534-16545 Positive_regulation denotes dysfunction
T5834 16546-16552 Positive_regulation denotes alters
T5830 16553-16558 Protein denotes IL-1β
T5833 16559-16569 Gene_expression denotes production
T5831 16653-16657 Protein denotes CFTR
T5839 16760-16765 Regulation denotes alter
T5840 16760-16765 Regulation denotes alter
T5835 16766-16771 Protein denotes IL-1β
T5836 16775-16779 Protein denotes IL-8
T5837 16780-16790 Gene_expression denotes production
T5838 16780-16790 Gene_expression denotes production
T5841 16850-16855 Protein denotes IL-1β
T5844 16856-16866 Gene_expression denotes production
T5842 16954-16964 Protein denotes CFTRinh172
T5843 16966-16969 Protein denotes Fig
T5845 16978-16982 Protein denotes IL-8
T5846 16984-16991 Protein denotes Fig. 8e
T5847 16997-17002 Protein denotes NF-κB
T5848 17013-17020 Protein denotes Fig. 8f
T15003 17130-17140 Negative_regulation denotes Disruption
T15001 17144-17148 Protein denotes CFTR
T15005 17167-17175 Positive_regulation denotes increase
T15002 17176-17181 Protein denotes IL-1β
T15004 17182-17192 Gene_expression denotes production
T15006 17353-17357 Protein denotes PAO1
T15007 17533-17543 Protein denotes CFTRinh172
T15008 17591-17596 Protein denotes IL-1β
T15009 17597-17607 Gene_expression denotes production
T15010 17706-17710 Protein denotes PAO1
T15011 17770-17772 Protein denotes κB
T15012 17773-17777 Protein denotes AP-1
T9156 17830-17835 Protein denotes IL-1β
T9157 17840-17849 Positive_regulation denotes increased
T9158 17926-17936 Gene_expression denotes production
T9162 18234-18241 Gene_expression denotes produce
T9159 18265-18270 Protein denotes IL-1β
T9164 18301-18309 Positive_regulation denotes increase
T9160 18313-18322 Protein denotes caspase-1
T9163 18323-18333 Positive_regulation denotes activation
T9161 18349-18353 Protein denotes PAO1
T9166 18510-18516 Gene_expression denotes source
T9165 18520-18525 Protein denotes IL-1β
T9167 18527-18531 Protein denotes CFTR
T9168 18535-18544 Gene_expression denotes expressed
T9172 18867-18877 Gene_expression denotes production
T9169 18881-18886 Protein denotes IL-1β
T9170 18888-18891 Protein denotes Fig
T9171 18975-18980 Protein denotes IL-1β
T9173 19247-19252 Protein denotes IL-1β
T9175 19351-19365 Gene_expression denotes overproduction
T9176 19351-19365 Positive_regulation denotes overproduction
T9174 19369-19374 Protein denotes IL-1β
T9180 19531-19538 Localization denotes secrete
T9181 19539-19548 Positive_regulation denotes increased
T9177 19560-19565 Protein denotes IL-1β
T9178 19581-19586 Protein denotes IL-1β
T9182 19587-19597 Gene_expression denotes production
T9183 19587-19597 Gene_expression denotes production
T9179 19601-19609 Protein denotes CF PBMCs
T9184 19618-19627 Positive_regulation denotes increased
T9185 19618-19627 Positive_regulation denotes increased
T9190 19765-19774 Positive_regulation denotes increased
T9191 19765-19774 Positive_regulation denotes increased
T9186 19775-19780 Protein denotes IL-1β
T9188 19781-19791 Gene_expression denotes production
T9189 19781-19791 Gene_expression denotes production
T9187 19795-19803 Protein denotes CF PBMCs
T9192 19935-19940 Protein denotes IL-1β
T9194 19941-19951 Gene_expression denotes production
T9195 19960-19969 Positive_regulation denotes increased
T9193 20072-20077 Protein denotes NF-κB
T9196 20078-20088 Positive_regulation denotes activation
T9199 20096-20105 Negative_regulation denotes deficient
T9197 20109-20113 Protein denotes CFTR
T9200 20140-20149 Positive_regulation denotes increased
T9198 20165-20170 Protein denotes NF-κB
T9201 20342-20347 Protein denotes IL-1β
T9202 20348-20357 Localization denotes secretion
T9205 20507-20516 Positive_regulation denotes increased
T9203 20517-20522 Protein denotes IL-1β
T9204 20523-20532 Localization denotes secretion
T9206 20618-20623 Protein denotes PBMCs
T9209 20624-20633 Gene_expression denotes expressed
T9210 20624-20633 Gene_expression denotes expressed
T9211 20634-20643 Positive_regulation denotes increased
T9207 20644-20655 Protein denotes basal NF-κB
T9213 20684-20692 Positive_regulation denotes increase
T9208 20696-20701 Protein denotes IL-1β
T9212 20702-20711 Localization denotes secretion
T9215 20755-20763 Positive_regulation denotes increase
T9214 20767-20772 Protein denotes IL-1β
T9217 20846-20856 Gene_expression denotes production
T9216 20860-20865 Protein denotes IL-1β
T9218 21003-21013 Protein denotes ΔF508 CFTR
T9223 21038-21045 Negative_regulation denotes reduced
T9221 21058-21065 Gene_expression denotes produce
T9219 21066-21071 Protein denotes IL-1β
T9224 21098-21104 Positive_regulation denotes induce
T9220 21114-21119 Protein denotes NF-κB
T9222 21120-21130 Positive_regulation denotes activation
T9230 21255-21265 Gene_expression denotes expressing
T9231 21255-21265 Gene_expression denotes expressing
T9225 21266-21271 Protein denotes ΔF508
T9226 21272-21276 Protein denotes CFTR
T9232 21277-21285 Gene_expression denotes produced
T9227 21307-21312 Protein denotes IL-1β
T9233 21342-21352 Gene_expression denotes expressing
T9228 21360-21364 Protein denotes CFTR
T9229 21380-21410 Protein denotes Burkholderia cenocepacia K56-2
T9235 21687-21697 Gene_expression denotes expression
T9234 21701-21705 Protein denotes CFTR
T9239 21793-21800 Gene_expression denotes produce
T9236 21818-21823 Protein denotes IL-1β
T9241 21865-21872 Regulation denotes effects
T9237 21876-21880 Protein denotes CFTR
T9238 21893-21898 Protein denotes IL-1β
T9240 21899-21909 Gene_expression denotes production
T9242 21960-21965 Protein denotes IL-1β
T9243 21966-21976 Gene_expression denotes production
T9246 22093-22100 Gene_expression denotes produce
T9247 22093-22100 Gene_expression denotes produce
T9244 22108-22113 Protein denotes IL-1β
T9245 22122-22131 Protein denotes caspase-1
T9248 22173-22178 Protein denotes NF-κB
T9250 22179-22189 Positive_regulation denotes activation
T9249 22221-22226 Protein denotes IL-1β
T9251 22227-22236 Localization denotes secretion
T9254 22296-22300 Regulation denotes role
T9252 22305-22310 Protein denotes NF-κB
T9253 22311-22321 Positive_regulation denotes activation
T9260 22420-22428 Negative_regulation denotes deletion
T9255 22432-22436 Protein denotes IKKβ
T9256 22460-22465 Protein denotes NF-κB
T9261 22466-22476 Positive_regulation denotes activation
T9264 22478-22487 Positive_regulation denotes increases
T9257 22488-22493 Protein denotes IL-1β
T9262 22494-22503 Localization denotes secretion
T9265 22561-22565 Positive_regulation denotes role
T9258 22570-22575 Protein denotes NF-κB
T9263 22579-22589 Regulation denotes regulation
T9259 22593-22598 Protein denotes IL-1β
T9266 22666-22670 Protein denotes IL-8
T9267 22711-22716 Protein denotes NF-κB
T9269 22857-22866 Regulation denotes dependent
T9268 22870-22875 Protein denotes NF-κB
T9270 22988-22993 Protein denotes NF-κB
T9273 23029-23038 Negative_regulation denotes inhibited
T9276 23029-23038 Negative_regulation denotes inhibited
T9277 23029-23038 Negative_regulation denotes inhibited
T9271 23044-23049 Protein denotes IL-1β
T9272 23054-23058 Protein denotes IL-8
T9274 23059-23068 Localization denotes secretion
T9275 23059-23068 Localization denotes secretion
T9278 23097-23102 Protein denotes IL-1β
T9279 23107-23111 Protein denotes IL-8
T9280 23156-23161 Protein denotes NF-κB
T9281 23162-23172 Positive_regulation denotes activation
T9293 23237-23243 Positive_regulation denotes induce
T9282 23253-23258 Protein denotes IL-1β
T9288 23259-23267 Positive_regulation denotes response
T9294 23317-23326 Positive_regulation denotes generated
T9295 23317-23326 Positive_regulation denotes generated
T9296 23317-23326 Positive_regulation denotes generated
T9297 23317-23326 Positive_regulation denotes generated
T9283 23335-23340 Protein denotes NF-κB
T9284 23341-23345 Protein denotes AP-1
T9289 23346-23356 Positive_regulation denotes activation
T9290 23346-23356 Positive_regulation denotes activation
T9291 23346-23356 Positive_regulation denotes activation
T9292 23346-23356 Positive_regulation denotes activation
T9285 23358-23365 Protein denotes Fig. 6a
T9286 23371-23385 Protein denotes IL-8 secretion
T9287 23387-23394 Protein denotes Fig. 6b
T9298 24269-24273 Protein denotes CFTR
T9299 24668-24672 Protein denotes exsA
T9300 24713-24717 Protein denotes exsA
T9303 24727-24736 Regulation denotes regulator
T9305 24790-24799 Positive_regulation denotes important
T9301 24804-24809 Protein denotes IL-1β
T9304 24810-24819 Localization denotes secretion
T9302 24897-24907 Protein denotes host IL-1β
T9306 25272-25277 Protein denotes NF-κB
T9307 25278-25290 Protein denotes Inflammasome
T10377 26097-26107 Gene_expression denotes expressing
T10378 26097-26107 Gene_expression denotes expressing
T10375 26112-26117 Protein denotes ΔF508
T10376 26122-26128 Protein denotes W1282X
T10379 26253-26257 Protein denotes CFTR
T10380 26365-26378 Protein denotes CFTR genotype
T10381 26380-26384 Protein denotes THP1
T10386 26404-26411 Gene_expression denotes express
T10387 26404-26411 Gene_expression denotes express
T10388 26414-26422 Localization denotes secreted
T10389 26414-26422 Localization denotes secreted
T10382 26423-26453 Protein denotes embryonic alkaline phosphatase
T10383 26455-26459 Protein denotes SEAP
T10390 26470-26479 Positive_regulation denotes inducible
T10391 26470-26479 Positive_regulation denotes inducible
T10384 26483-26488 Protein denotes NF-κB
T10385 26493-26509 Protein denotes AP-1 (Invivogen)
T10392 26834-26855 Protein denotes supplement bullet kit
T10393 26857-26860 Protein denotes EGF
T10394 26904-26915 Protein denotes transferrin
T10395 26917-26931 Protein denotes bovine insulin
T10396 27184-27188 Protein denotes THP1
T10397 27227-27231 Protein denotes RPMI
T10401 27292-27302 Gene_expression denotes expressing
T10402 27292-27302 Gene_expression denotes expressing
T10403 27292-27302 Gene_expression denotes expressing
T10398 27307-27314 Protein denotes SEAP NF
T10399 27315-27317 Protein denotes κB
T10400 27318-27331 Protein denotes AP-1 reporter
T10404 27528-27530 Protein denotes S9
T10405 27535-27540 Protein denotes IB3-1
T10406 27582-27602 Protein denotes bovine serum albumin
T10407 27616-27627 Protein denotes fibronectin
T10408 27741-27757 Protein denotes collagen type IV
T10860 29100-29113 Protein denotes complete RPMI
T11369 29862-29866 Protein denotes PAO1
T11370 29938-29942 Protein denotes PAO1
T11371 30211-30216 Protein denotes NF-κB
T11372 30391-30416 Protein denotes CFTR inhibitor CFTRinh172
T11373 30418-30431 Protein denotes Sigma Aldrich
T11374 30503-30512 Protein denotes caspase-1
T11748 30926-30955 Protein denotes Halt protease and phosphatase
T11749 31301-31334 Protein denotes IκBα (Cell Signaling), or β-actin
T11750 31596-31609 Protein denotes serum albumin
T12128 31797-31806 Protein denotes caspase-1
T12129 32001-32005 Protein denotes PAO1
T12130 32284-32288 Protein denotes PAO1
T12131 32302-32311 Protein denotes Caspase-1
T12133 32433-32438 Binding denotes binds
T12132 32446-32455 Protein denotes caspase-1
T12134 32544-32548 Protein denotes CD14
T12135 32661-32665 Protein denotes CD14
T12136 32666-32674 Gene_expression denotes positive
T12293 32752-32757 Protein denotes NF-κB
T12294 32758-32762 Protein denotes AP-1
T12295 32956-32976 Protein denotes alkaline phosphatase
T12296 33006-33011 Protein denotes NF-κB
T12297 33012-33016 Protein denotes AP-1
T12602 33587-33591 Protein denotes PAO1
T12603 33698-33702 Protein denotes PAO1
T12604 33876-33880 Protein denotes PAO1
T12605 33959-33963 Protein denotes PAO1
R10742 T12132 T12133 themeOf caspase-1,binds
R10743 T12135 T12136 themeOf CD14,positive
R11615 T13106 T13107 themeOf IL-1β,production
R11616 T13109 T13111 themeOf IL-1β,production
R11617 T13110 T13112 themeOf IL-8,production
R11887 T13403 T13404 themeOf caspase-1,upregulate
R12095 T13623 T13624 themeOf caspase-1,increases
R12339 T13902 T13903 themeOf IL-1β,produce
R12340 T13902 T13904 themeOf IL-1β,increased
R12341 T13905 T13907 themeOf aeruginosa PAO1,lacking
R12342 T13906 T13908 themeOf exsA,lacking
R12343 T13909 T13910 themeOf exsA,lacking
R12872 T14485 T14487 themeOf NF-κB,activation
R12873 T14486 T14488 themeOf IL-1β,production
R12874 T14487 T14490 causeOf activation,potentiates
R12875 T14488 T14489 themeOf production,degree
R12876 T14489 T14490 themeOf degree,potentiates
R12877 T14495 T14498 themeOf κB,secretion
R12878 T14497 T14499 themeOf IL-1β,secretion
R13332 T15001 T15003 themeOf CFTR,Disruption
R13333 T15002 T15004 themeOf IL-1β,production
R13334 T15003 T15005 causeOf Disruption,increase
R13335 T15004 T15005 themeOf production,increase
R13336 T15008 T15009 themeOf IL-1β,production
R2173 T2515 T2516 themeOf CFTR,lacking
R2181 T2517 T2519 themeOf Interleukin-1 beta,mediator
R2186 T2518 T2520 themeOf IL-1β,mediator
R2189 T2521 T2523 themeOf IL-6,induction
R2190 T2522 T2524 themeOf IL-8,induction
R2191 T2526 T2527 themeOf IL-1β,produced
R2192 T2528 T2530 themeOf IL-1β,secretion
R2193 T2529 T2531 themeOf pro-IL-18,secretion
R2194 T2533 T2536 themeOf IL-1β,increase
R2195 T2534 T2537 themeOf IL-6,increase
R2196 T2535 T2538 themeOf IL-8,increase
R2197 T2541 T2542 themeOf IL-1β,expression
R2198 T2542 T2543 themeOf expression,upregulation
R2199 T2545 T2546 themeOf IL-1β,increased
R2200 T2549 T2552 themeOf IL-1β,expression
R2201 T2550 T2553 themeOf CFTR,loss
R2202 T2551 T2554 themeOf NF-κB,activation
R2203 T2552 T2555 themeOf expression,increases
R2204 T2553 T2556 causeOf loss,increases
R2205 T2554 T2556 themeOf activation,increases
R2206 T2557 T2560 themeOf IL-1β,secretion
R2207 T2559 T2561 themeOf NLRP3,activation
R2208 T2560 T2562 themeOf secretion,increases
R2651 T3057 T3058 themeOf IL-1β,produce
R2652 T3059 T3062 themeOf IL-1β,production
R2653 T3062 T3063 themeOf production,increased
R2654 T3064 T3066 themeOf IL-1β,increased
R2655 T3065 T3067 themeOf IL-1β,production
R2656 T3067 T3068 themeOf production,increase
R2657 T3070 T3072 themeOf IL-8,producing
R2658 T3071 T3073 themeOf Fig,producing
R2927 T3378 T3379 themeOf caspase-1,upregulate
R2928 T3381 T3391 causeOf caspase-1,role
R2929 T3382 T3388 themeOf NF-κB,activation
R2930 T3385 T3389 themeOf caspase-1,inhibition
R2931 T3386 T3393 causeOf NF-κB,dependent
R2932 T3387 T3390 themeOf IL-6,production
R2933 T3388 T3391 themeOf activation,role
R2934 T3390 T3392 themeOf production,altered
R2935 T3390 T3393 themeOf production,dependent
R2936 T3395 T3397 themeOf IL-6,secretion
R2937 T3397 T3398 themeOf secretion,decrease
R3097 T3573 T3574 themeOf caspase-1,increases
R3098 T3577 T3581 themeOf caspase-1,activation
R3099 T3581 T3582 themeOf activation,increase
R3727 T4279 T4280 themeOf IL-1β,produce
R3728 T4279 T4281 themeOf IL-1β,increased
R3729 T4282 T4283 themeOf NF-κB,increased
R3730 T4282 T4284 themeOf NF-κB,secretion
R3731 T4284 T4285 themeOf secretion,increased
R3732 T4287 T4289 themeOf NLRC4,activate
R3733 T4288 T4290 themeOf NLRP3,activate
R3734 T4291 T4295 themeOf IL-1β,produce
R3735 T4291 T4299 themeOf IL-1β,increased
R3736 T4292 T4296 themeOf Fig. 5a,produce
R3737 T4292 T4300 themeOf Fig. 5a,increased
R3738 T4293 T4297 themeOf IL-8,produce
R3739 T4293 T4301 themeOf IL-8,increased
R3740 T4294 T4298 themeOf Fig. 5b,produce
R3741 T4294 T4302 themeOf Fig. 5b,increased
R3742 T4303 T4304 themeOf IL-1β,produced
R3743 T4305 T4309 themeOf exsA,lacks
R3744 T4306 T4310 themeOf PAO1ΔexsA,lacks
R3745 T4307 T4311 themeOf IL-1β,produced
R3746 T4312 T4313 themeOf IL-1β,production
R3747 T4313 T4314 themeOf production,result
R3748 T4315 T4318 themeOf IL-1β,production
R3749 T4316 T4319 themeOf IL-8,production
R3750 T4318 T4320 themeOf production,increased
R3751 T4319 T4321 themeOf production,increased
R4444 T5117 T5120 themeOf NF-κB,activation
R4445 T5118 T5121 themeOf IL-1β,responses
R4446 T5119 T5122 themeOf IL-8,responses
R4447 T5123 T5129 causeOf PAO1,induced
R4448 T5123 T5137 causeOf PAO1,induced
R4449 T5123 T5138 causeOf PAO1,induced
R4450 T5124 T5129 themeOf IL-1β,induced
R4451 T5124 T5130 themeOf IL-1β,production
R4452 T5124 T5133 causeOf IL-1β,dependence
R4453 T5124 T5134 causeOf IL-1β,dependence
R4454 T5124 T5135 causeOf IL-1β,dependence
R4455 T5124 T5136 causeOf IL-1β,dependence
R4456 T5125 T5131 themeOf IL-8,production
R4457 T5126 T5132 themeOf NF-κB,activation
R4458 T5129 T5133 themeOf induced,dependence
R4459 T5130 T5134 themeOf production,dependence
R4460 T5130 T5137 themeOf production,induced
R4461 T5131 T5135 themeOf production,dependence
R4462 T5131 T5138 themeOf production,induced
R4463 T5132 T5136 themeOf activation,dependence
R4464 T5140 T5149 themeOf NF-κB,activation
R4465 T5141 T5150 themeOf AP-1,activation
R4466 T5142 T5147 themeOf Fig. 6a,produced
R4467 T5144 T5148 themeOf Fig. 6b,produced
R4468 T5145 T5151 themeOf IL-1β,amounts
R4469 T5146 T5152 themeOf Fig. 6c,secreted
R4470 T5154 T5159 themeOf NF-κB,increase
R4471 T5156 T5160 themeOf Fig. 6a,increase
R4472 T5157 T5161 themeOf IL-8 secretion,increase
R4473 T5158 T5162 themeOf Fig. 6b,increase
R4474 T5163 T5167 themeOf IL-1β,production
R4475 T5167 T5168 themeOf production,augmented
R4476 T5169 T5173 themeOf NF-κB,activation
R4477 T5170 T5174 themeOf IL-1β,secretion
R4478 T5172 T5175 themeOf IL-1β,production
R4479 T5175 T5176 themeOf production,augmenting
R4480 T5178 T5184 themeOf NF-κB,inhibition
R4481 T5179 T5185 themeOf IκBα,phosphorylation
R4482 T5182 T5186 themeOf IL-1β,production
R4483 T5184 T5190 causeOf inhibition,reduced
R4484 T5185 T5187 themeOf phosphorylation,inhibitor
R4485 T5186 T5188 themeOf production,activation
R4486 T5186 T5189 themeOf production,subsequent
R4487 T5188 T5190 themeOf activation,reduced
R4488 T5191 T5198 causeOf NF-κB,modulator
R4489 T5192 T5195 themeOf IL-1β,production
R4490 T5193 T5196 themeOf NF-κB,activation
R4491 T5194 T5197 themeOf IL-1β,production
R4492 T5195 T5198 themeOf production,modulator
R4493 T5196 T5199 themeOf activation,increased
R4494 T5197 T5200 themeOf production,augments
R4729 T5457 T5459 themeOf NF-κB,inhibition
R4730 T5458 T5460 themeOf NLRP3 inflammasome,inhibit
R4731 T5459 T5460 causeOf inhibition,inhibit
R4732 T5461 T5466 themeOf NF-κB,inhibitor
R4733 T5462 T5467 themeOf CFTR,inhibition
R4734 T5463 T5467 causeOf CFTRinh172,inhibition
R4735 T5468 T5471 themeOf IκBα,degradation
R4736 T5469 T5472 themeOf PAO1,stimulation
R4737 T5471 T5473 themeOf degradation,inhibit
R4738 T5472 T5474 themeOf stimulation,inhibit
R5042 T5823 T5825 themeOf CFTR,Disruption
R5043 T5824 T5826 themeOf IL-1β,production
R5044 T5825 T5827 causeOf Disruption,increase
R5045 T5826 T5827 themeOf production,increase
R5046 T5829 T5832 themeOf CFTR,dysfunction
R5047 T5830 T5833 themeOf IL-1β,production
R5048 T5832 T5834 causeOf dysfunction,alters
R5049 T5833 T5834 themeOf production,alters
R5050 T5835 T5837 themeOf IL-1β,production
R5051 T5836 T5838 themeOf IL-8,production
R5052 T5837 T5839 themeOf production,alter
R5053 T5838 T5840 themeOf production,alter
R5054 T5841 T5844 themeOf IL-1β,production
R667 T802 T804 themeOf Interleukin-1 beta,mediator
R668 T803 T805 themeOf IL-1β,mediator
R669 T806 T807 themeOf IL-1β,Secretion
R670 T809 T811 themeOf IL-1β,produce
R671 T810 T812 themeOf caspase-1,upregulate
R672 T813 T815 themeOf IL-1β,produced
R673 T814 T816 themeOf caspase-1,upregulated
R674 T816 T817 themeOf upregulated,amounts
R675 T818 T820 themeOf caspase-1,activation
R676 T819 T821 themeOf IL-1β,production
R677 T821 T822 themeOf production,activation
R678 T823 T825 themeOf IL-1β,production
R679 T825 T826 themeOf production,dependent
R680 T825 T827 themeOf production,enhanced
R681 T828 T831 themeOf CFTR,inhibition
R682 T829 T832 themeOf IL-1β,production
R683 T830 T833 themeOf IL-8,production
R684 T832 T834 themeOf production,alter
R685 T833 T835 themeOf production,alter
R686 T837 T839 themeOf IL-1β,secretion
R687 T838 T840 themeOf CF pathogen Pseudomonas aeruginosa,secretion
R688 T841 T844 themeOf IL-1β,production
R689 T842 T846 themeOf NF-κB,increase
R690 T843 T847 themeOf CFTR,loss
R691 T844 T845 themeOf production,due
R692 T844 T848 themeOf production,increased
R7997 T9156 T9157 themeOf IL-1β,increased
R8000 T9156 T9158 themeOf IL-1β,production
R8001 T9159 T9162 themeOf IL-1β,produce
R8002 T9160 T9163 themeOf caspase-1,activation
R8003 T9163 T9164 themeOf activation,increase
R8008 T9165 T9166 themeOf IL-1β,source
R8010 T9167 T9168 themeOf CFTR,expressed
R8014 T9169 T9172 themeOf IL-1β,production
R8018 T9174 T9175 themeOf IL-1β,overproduction
R8021 T9175 T9176 themeOf overproduction,overproduction
R8024 T9177 T9180 themeOf IL-1β,secrete
R8027 T9177 T9181 themeOf IL-1β,increased
R8029 T9178 T9182 themeOf IL-1β,production
R8032 T9179 T9183 themeOf CF PBMCs,production
R8035 T9182 T9184 themeOf production,increased
R8041 T9183 T9185 themeOf production,increased
R8044 T9186 T9188 themeOf IL-1β,production
R8049 T9187 T9189 themeOf CF PBMCs,production
R8051 T9188 T9190 themeOf production,increased
R8052 T9189 T9191 themeOf production,increased
R8054 T9192 T9194 themeOf IL-1β,production
R8057 T9193 T9196 themeOf NF-κB,activation
R8061 T9194 T9195 themeOf production,increased
R8064 T9197 T9199 themeOf CFTR,deficient
R8068 T9198 T9200 themeOf NF-κB,increased
R8071 T9258 T9265 causeOf NF-κB,role
R8072 T9259 T9263 themeOf IL-1β,regulation
R8073 T9260 T9264 causeOf deletion,increases
R8074 T9262 T9264 themeOf secretion,increases
R8075 T9263 T9265 themeOf regulation,role
R8076 T9268 T9269 themeOf NF-κB,dependent
R8077 T9271 T9273 themeOf IL-1β,inhibited
R8078 T9201 T9202 themeOf IL-1β,secretion
R8079 T9271 T9274 themeOf IL-1β,secretion
R8080 T9272 T9275 themeOf IL-8,secretion
R8081 T9203 T9204 themeOf IL-1β,secretion
R8082 T9204 T9205 themeOf secretion,increased
R8083 T9274 T9276 themeOf secretion,inhibited
R8084 T9206 T9209 themeOf PBMCs,expressed
R8085 T9207 T9210 themeOf basal NF-κB,expressed
R8086 T9207 T9211 themeOf basal NF-κB,increased
R8087 T9208 T9212 themeOf IL-1β,secretion
R8088 T9275 T9277 themeOf secretion,inhibited
R8089 T9212 T9213 themeOf secretion,increase
R8090 T9280 T9281 themeOf NF-κB,activation
R8091 T9214 T9215 themeOf IL-1β,increase
R8092 T9216 T9217 themeOf IL-1β,production
R8093 T9219 T9221 themeOf IL-1β,produce
R8094 T9220 T9222 themeOf NF-κB,activation
R8095 T9221 T9223 themeOf produce,reduced
R8096 T9282 T9288 themeOf IL-1β,response
R8097 T9283 T9289 themeOf NF-κB,activation
R8098 T9222 T9224 themeOf activation,induce
R8099 T9284 T9290 themeOf AP-1,activation
R8100 T9225 T9230 themeOf ΔF508,expressing
R8101 T9226 T9231 themeOf CFTR,expressing
R8102 T9285 T9291 themeOf Fig. 6a,activation
R8103 T9227 T9232 themeOf IL-1β,produced
R8104 T9228 T9233 themeOf CFTR,expressing
R8105 T9286 T9292 themeOf IL-8 secretion,activation
R8106 T9288 T9293 themeOf response,induce
R8107 T9234 T9235 themeOf CFTR,expression
R8108 T9289 T9294 themeOf activation,generated
R8109 T9236 T9239 themeOf IL-1β,produce
R8110 T9290 T9295 themeOf activation,generated
R8111 T9238 T9240 themeOf IL-1β,production
R8112 T9291 T9296 themeOf activation,generated
R8113 T9240 T9241 themeOf production,effects
R8114 T9242 T9243 themeOf IL-1β,production
R8115 T9292 T9297 themeOf activation,generated
R8116 T9244 T9246 themeOf IL-1β,produce
R8117 T9300 T9303 themeOf exsA,regulator
R8118 T9245 T9247 themeOf caspase-1,produce
R8119 T9248 T9250 themeOf NF-κB,activation
R8120 T9249 T9251 themeOf IL-1β,secretion
R8121 T9252 T9253 themeOf NF-κB,activation
R8122 T9253 T9254 themeOf activation,role
R8123 T9255 T9260 themeOf IKKβ,deletion
R8124 T9256 T9261 themeOf NF-κB,activation
R8125 T9301 T9304 themeOf IL-1β,secretion
R8126 T9257 T9262 themeOf IL-1β,secretion
R8127 T9304 T9305 themeOf secretion,important
R9119 T10375 T10377 themeOf ΔF508,expressing
R9120 T10376 T10378 themeOf W1282X,expressing
R9121 T10382 T10386 themeOf embryonic alkaline phosphatase,express
R9122 T10382 T10388 themeOf embryonic alkaline phosphatase,secreted
R9123 T10382 T10390 themeOf embryonic alkaline phosphatase,inducible
R9124 T10382 T10391 themeOf embryonic alkaline phosphatase,inducible
R9125 T10383 T10387 themeOf SEAP,express
R9126 T10383 T10389 themeOf SEAP,secreted
R9127 T10384 T10390 causeOf NF-κB,inducible
R9128 T10385 T10391 causeOf AP-1 (Invivogen),inducible
R9129 T10398 T10401 themeOf SEAP NF,expressing
R9130 T10399 T10402 themeOf κB,expressing
R9131 T10400 T10403 themeOf AP-1 reporter,expressing