| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T181 |
0-273 |
Sentence |
denotes |
Separate streams of the mononuclear phagocyte lineage co-exist to generate monocytic, granulocytic and dendritic cell-like monocytes [78], and the impact of COVID-19 infection on monocyte activation needs to be determined to identify targets for diagnosis and intervention. |
| T182 |
274-540 |
Sentence |
denotes |
The different monocytic lineage receptors for CSF1, 2 and 3 provide direct markers of disturbed haematopoiesis and skewed cell differentiation [79]; and can be combined with downstream effectors such as CD14 [80] and FcR to determine their full activation potential. |
| T183 |
541-777 |
Sentence |
denotes |
Anti-growth factor/cytokine receptor antibodies may therefore be more effective in attenuating a hyperinflammatory storm and attendant organ damage than using individual anti-cytokine reagents for GM-CSF, IL-6 and TNF, for example [22]. |
| T184 |
778-924 |
Sentence |
denotes |
Recent studies with anti CSF2R blockade by mavrilimumab show promise [12,81] and anti CSF1R blockade presents an alternative or additional option. |
| T185 |
925-1038 |
Sentence |
denotes |
Repurposing trials of anti-inflammatory drugs have targeted a variety of macrophage pathways, with mixed results. |
| T186 |
1039-1391 |
Sentence |
denotes |
In each case, we have to weigh potential benefits against interfering with macrophage antimicrobial and other essential functions such as antiviral-antibody dependent killing, clearance of necrotic cells and debris, and repair, as well as the risk of potentiating inflammatory responses of mononuclear phagocytes through antibody -dependent mechanisms. |
