| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T57 |
0-64 |
Sentence |
denotes |
Meanwhile, SARS-CoV-2 can contribute to CNS symptoms indirectly. |
| T58 |
65-196 |
Sentence |
denotes |
It is known that cytokine storm syndrome and immunosuppression are important factors accelerating the progression of COVID-19 [15]. |
| T59 |
197-350 |
Sentence |
denotes |
Some HCoVs can contribute to CNS demyelinating diseases by triggering immune dysfunction, and similar cases have been reported in SARS-CoV-2 as well [7]. |
| T60 |
351-488 |
Sentence |
denotes |
A 71-year-old man, who had been hospitalized for cardiac disease initially, was diagnosed with COVID-19 and died after more than 2 weeks. |
| T61 |
489-662 |
Sentence |
denotes |
In the subsequent post-mortem analysis, pathologic changes have been observed in the brain tissue with features resembling both acute hemorrhagic leukoencephalitis and ADEM. |
| T62 |
663-860 |
Sentence |
denotes |
This indicates that SARS-CoV-2 may induce CNS tissue damage though cytokine pathways and the patients who burdened by severe infection might be more prone to serious neuropathological consequences. |
| T63 |
861-1118 |
Sentence |
denotes |
In turn, viral infection of CNS may also lead to the impairment of immune response, partly because the virus can influence the neuroendocrine system in releasing glucocorticoids and other peptides, which is called “neuroendocrine-immune crosstalk” (Fig. 1). |
| T64 |
1119-1354 |
Sentence |
denotes |
Besides, an autopsy of 18 COVID-19 patients showed that only hypoxic changes, rather than specific changes referable to viral infection, have been observed in the brain specimens, even in some patients presenting with CNS symptoms [6]. |
| T65 |
1355-1501 |
Sentence |
denotes |
This is partly because SARS-CoV-2 infection is often associated with pulmonary and systemic diseases that may lead to neurological manifestations. |
