| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T3 |
0-161 |
Sentence |
denotes |
A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. |
| T4 |
162-349 |
Sentence |
denotes |
The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for these antiviral effects. |
| T5 |
350-577 |
Sentence |
denotes |
The physicochemical properties of both hydroxychloroquine and azithromycin are consistent with particularly high affinity for the intracellular lysosomal space, which has been implicated as a target site for antiviral activity. |
| T6 |
578-777 |
Sentence |
denotes |
The properties of both drugs predict dramatic accumulation in lysosomes, with calculated lysosomal drug concentrations that exceed cytosolic and extracellular concentrations by more than 50 000-fold. |
| T7 |
778-918 |
Sentence |
denotes |
These predictions are consistent with previously reported experimentally measured cellular and extracellular concentrations of azithromycin. |
| T8 |
919-1058 |
Sentence |
denotes |
This is also reflected in the very large volumes of distribution of these drugs, which are among the highest of all drugs currently in use. |
| T9 |
1059-1167 |
Sentence |
denotes |
The combination of hydroxychloroquine and azithromycin produces very high local concentrations in lysosomes. |
| T10 |
1168-1404 |
Sentence |
denotes |
The clinical significance of this observation is unclear; however, the magnitude of this mechanism of drug accumulation via ion-trapping in lysosomes could be an important factor for the pharmacodynamic effects of this drug combination. |
