| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T62 |
0-214 |
Sentence |
denotes |
When the same ion-trapping concepts are applied to azithromycin, the expected accumulation ratio in lysosomes compared with cytosol is calculated as 52 000-fold, which is very similar to that of hydroxychloroquine. |
| T63 |
215-374 |
Sentence |
denotes |
After administration of azithromycin, a large fraction of the dose will reside in lysosomes where it also binds to acidic phospholipids [10], [11], [12], [13]. |
| T64 |
375-442 |
Sentence |
denotes |
A clinical study supports azithromycin lysosomal accumulation [14]. |
| T65 |
443-596 |
Sentence |
denotes |
In this study, the experimentally measured average total azithromycin concentrations in polymorphonuclear white blood cells (PMLs) was over 14 000 ng/mL. |
| T66 |
597-809 |
Sentence |
denotes |
However, the model-predicted unionized azithromycin concentration of 6.0 ng/mL in the cytosol of PMLs was comparable to the measured interstitial concentrations in the muscle (8.7 ng/mL) and subcutis (4.1 ng/mL). |
| T67 |
810-968 |
Sentence |
denotes |
Hence, the measured concentrations in white blood cells was approximately 2000-fold higher than the measured unbound concentrations in the interstitial space. |
| T68 |
969-1254 |
Sentence |
denotes |
Considering the lysosomal volume is estimated to range between 0.5 to 5% of the cellular volume depending on cell type [14], [15], [16], [17], these concentrations are consistent with the expected magnitude of lysosomal accumulation and explain these very high cellular concentrations. |
