| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T55 |
0-249 |
Sentence |
denotes |
When the above described concepts are applied to hydroxychloroquine, the expected accumulation ratio in lysosomes compared with cytosol is calculated as 56 000-fold; therefore, after drug intake a large fraction of the dose will reside in lysosomes. |
| T56 |
250-366 |
Sentence |
denotes |
This is confirmed by the known pharmacokinetic parameters for hydroxychloroquine derived from plasma concentrations. |
| T57 |
367-581 |
Sentence |
denotes |
After intravenous administration to healthy volunteers (average weight 63.5 kg), the volume of distribution of hydroxychloroquine was reported to be over 44 000 L, which is equivalent to approximately 700 L/kg [9]. |
| T58 |
582-740 |
Sentence |
denotes |
This means that most of the drug in the body resides in the tissues, which is consistent with the predicted extraordinarily high lysosomal accumulation ratio. |
| T59 |
741-841 |
Sentence |
denotes |
Furthermore, it explains the very long half-life (approximately 40 days) reported in the same study. |
| T60 |
842-973 |
Sentence |
denotes |
In this study, hydroxychloroquine could still be detected in blood more than 6 months after a single dose administration of 310 mg. |
