LitCovid-sentences  

PMC:7126544 / 57626-65329 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T458 0-28 Sentence denotes 11 Treatment and management
T459 29-98 Sentence denotes There is no clear, unified and effective treatment plan for COVID-19.
T460 99-201 Sentence denotes Most guidelines emphasize early identification, early isolation, early diagnosis, and early treatment.
T461 202-336 Sentence denotes The treatment and management of SARS-CoV-2 pneumonia mainly include the following aspects (Fig. 8 ) [37,[78], [79], [80], [81], [82]].
T462 337-395 Sentence denotes Fig. 8 The treatment and management of COVID-19 pneumonia.
T463 396-464 Sentence denotes ICU: intensive care unit; ECMO: extracorporeal membrane oxygenation.
T464 465-621 Sentence denotes Suspected and confirmed cases should be isolated and treated in designated hospitals with effective isolation and protective conditions as soon as possible.
T465 622-674 Sentence denotes Suspected cases should be isolated in a single room.
T466 675-889 Sentence denotes WHO suggests that patients with mild symptoms and without underlying chronic diseases (such as lung or heart disease, renal failure, or immunodeficiency) may be cared for in the home environment in isolation [131].
T467 890-1005 Sentence denotes However, severe cases should be hospitalized, and critical cases should be admitted to the ICU as soon as possible.
T468 1006-1193 Sentence denotes Supportive therapy includes bedrest, adequate nutrition, monitoring vital signs and oxygen saturation, prevention of dehydration and maintaining water, electrolyte, and acid-base balance.
T469 1194-1529 Sentence denotes For severe cases, it may be necessary to proactively prevent complications and secondary infections, treat underlying diseases and provide organ function support according to the patients’ condition such as that reported by Chen et all that involved the administration of intravenous immunoglobulin therapy to 27 of such patients [37].
T470 1530-1618 Sentence denotes Supplemental oxygen should be administered to patients with decreased oxygen saturation.
T471 1619-1762 Sentence denotes In Huang's study [26], four (10%) patients needed invasive mechanical ventilation, and two received extracorporeal membrane oxygenation (ECMO).
T472 1763-1995 Sentence denotes In Chen's study [37], 75 of 99 patients received oxygen therapy, 13 patients required non-invasive mechanical ventilation, four patients needed an invasive ventilator to assist ventilation, and three patients were treated with ECMO.
T473 1996-2224 Sentence denotes In Wang's study [83], of the 36 patients in the ICU, four patients received high-flow oxygen therapy, 15 patients received non-invasive ventilation, and 17 patients received invasive ventilation (four patients switched to ECMO).
T474 2225-2377 Sentence denotes In Guan's study, 418 of 1099 patients received oxygen therapy, 67 patients received mechanical ventilation, and ECMO was adopted in 5 severe cases [85].
T475 2378-2514 Sentence denotes Due to lack of valid evidence and possible adverse effects, routine use of corticosteroid should be avoided unless for specific reasons.
T476 2515-2742 Sentence denotes Baillie JK et al. [42] suggested that corticosteroid should not be used for the treatment of SARS-CoV-2-induced lung injury or shock, because of the lack of evidence that patients with COVID-19 will benefit from corticosteroid.
T477 2743-2855 Sentence denotes In the first 41 patients, only 22% (9/41) patients were given corticosteroid, with six of these in the ICU [26].
T478 2856-2956 Sentence denotes Chen et al. reported that 19% (19/99) patients received corticosteroid treatment for 3–15 days [37].
T479 2957-3035 Sentence denotes In Wang's study [83], 45% (62/138) patients received corticosteroid treatment.
T480 3036-3123 Sentence denotes In Guan's study, 18.6% (204/1099) of patients were given systemic corticosteroids [85].
T481 3124-3257 Sentence denotes Indiscriminate or inappropriate antimicrobial treatment, especially the combination of broad-spectrum antibiotics, should be avoided.
T482 3258-3338 Sentence denotes However, in Huang's study [26], all his 41 patients received antibiotic therapy.
T483 3339-3514 Sentence denotes In Chen's study [37], 70 patients were given antibiotic treatment, among whom 25 patients were treated with a single antibiotic and 45 patients were given combination therapy.
T484 3515-3566 Sentence denotes The duration of antibiotic treatment was 3–17 days.
T485 3567-3637 Sentence denotes In addition, there were 15 patients who received antifungal treatment.
T486 3638-3800 Sentence denotes In Wang's study [83], the 138 hospitalized patients all received antibacterial therapy, including moxifloxacin (64.4%), ceftriaxone (24.6%), azithromycin (18.1%).
T487 3801-3922 Sentence denotes In Guan's study, 632 patients were given intravenous antibiotics, and 30 patients were given antifungal medications [85].
T488 3923-4032 Sentence denotes At present, there is no evidence-based medicine to support the effectiveness of antiviral drugs for COVID-19.
T489 4033-4166 Sentence denotes The previous experience of treating SARS-CoV, MERS-CoV or influenza infections guides the selection of antiviral agents for COVID-19.
T490 4167-4274 Sentence denotes The current guideline of the NHC recommends IFN-α, lopinavir/ritonavir, and ribavirin as antiviral therapy.
T491 4275-4345 Sentence denotes In Huang's study [26], 38 of 41 patients were given antiviral therapy.
T492 4346-4473 Sentence denotes The Jinyintan hospital has launched a randomized, controlled trial of the anti-HIV drug combination of lopinavir and ritonavir.
T493 4474-4653 Sentence denotes In Chen's study [37], 75 patients received antiviral treatment, including oseltamivir, ganciclovir, and lopinavir/ritonavir, and the duration of antiviral treatment was 3–14 days.
T494 4654-4737 Sentence denotes In Wang's study [83], there were 89.9% (124/138) patients who received oseltamivir.
T495 4738-4814 Sentence denotes And in Guan's study, 35.8% (393/1099) of patients received oseltamivir [85].
T496 4815-4911 Sentence denotes The anti-viral drug remdesivir (Gilead®) is in clinical trials to treat COVID-19 in Wuhan [132].
T497 4912-4987 Sentence denotes Chloroquine phosphate has also been shown to be effective in some patients.
T498 4988-5119 Sentence denotes Identifying or developing novel drug treatment options as soon as possible is critical for the response to the SARS-CoV-2 outbreak.
T499 5120-5369 Sentence denotes Based on the structural information of clinical effective medicines for SARS-CoV-2, Liu et al. predicted 10 commercial medicines which may function as inhibitors of SARS-CoV-2, including colistin, valrubicin, icatibant, bepotastine, epirubicin, etc.
T500 5370-5455 Sentence denotes Some of these may be more resistant to viral mutation than lopinavir/ritonavir [133].
T501 5456-5554 Sentence denotes Stebbing et al. suggested that baricitinib may reduce both the viral entry and inflammation [134].
T502 5555-5744 Sentence denotes Lu reported that remdesivir may have the greatest potential for the successful treatment of SARS-CoV-2, but the efficacy and safety of remdesivir in COVID-19 needs further evaluation [135].
T503 5745-5965 Sentence denotes The antiviral efficiency of five FAD-approved drugs and two well-known broad-spectrum antiviral drugs have been studied and it has been found that remdesivir and chloroquine effectively inhibit SARS-CoV-2 in vitro [136].
T504 5966-6157 Sentence denotes The New England Journal of Medicine reported that the first case of COVID-19 confirmed in the United States was treated with intravenous remdesivir and demonstrated clinical improvement [71].
T505 6158-6331 Sentence denotes At present, a randomized, double-blind, placebo-controlled phase III clinical trial of remdesivir has been launched and already 761 confirmed cases have been enrolled [132].
T506 6332-6452 Sentence denotes Lu also pointed out that there is no direct evidence that oseltamivir is effective in the treatment of SARS-CoV-2 [135].
T507 6453-6561 Sentence denotes However, we found that oral oseltamivir or abidol has been used for suspected or confirmed SARS-CoV-2 cases.
T508 6562-6748 Sentence denotes Favilavir, formerly known as Fapilavir, was the first anti-novel coronavirus drug that has been approved for marketing by the National Medical Products Administration since the outbreak.
T509 6749-6901 Sentence denotes The drug was developed by Zhejiang Hisun Pharmaceutical Company and is expected to play an important role in preventing and treating the epidemic [137].
T510 6902-7070 Sentence denotes The role of intestinal microecological regulators that can be used to maintain intestinal microecological balance and prevent secondary bacterial infections is unclear.
T511 7071-7267 Sentence denotes Chinese traditional medicine suggests Shufengjiedu and Lianhuaqingwen, which have played a role in the prevention and treatment of new infectious respiratory diseases, may be of benefit [138,139].
T512 7268-7332 Sentence denotes Anxiety and fear often exist in suspected or confirmed patients.
T513 7333-7584 Sentence denotes Emergency psychological crisis intervention [140], and the implementation of classified intervention for different groups of people, is helpful in order to strengthen psychological counseling and reduce the psychological damage caused by the epidemic.
T514 7585-7703 Sentence denotes Mass hysteria has also led to incidences of racial discrimination against Asians, particularly in non-Asian countries.