| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-101 |
Sentence |
denotes |
Hypertension and its severity or mortality in Coronavirus Disease 2019 (COVID-19): a pooled analysis. |
| TextSentencer_T2 |
102-115 |
Sentence |
denotes |
INTRODUCTION: |
| TextSentencer_T3 |
116-323 |
Sentence |
denotes |
As the coronavirus disease 2019 (COVID-19) outbreak, identification of clinical predictors of severe or fatal disease are necessary to enable risk stratification and optimize allocation of limited resources. |
| TextSentencer_T4 |
324-467 |
Sentence |
denotes |
Hypertension has been widely reported to be associated with increase disease severity, however, other studies have reported different findings. |
| TextSentencer_T5 |
468-479 |
Sentence |
denotes |
OBJECTIVES: |
| TextSentencer_T6 |
480-554 |
Sentence |
denotes |
To evaluate the association of hypertension and severe and fatal COVID-19. |
| TextSentencer_T7 |
555-576 |
Sentence |
denotes |
PATIENTS AND METHODS: |
| TextSentencer_T8 |
577-774 |
Sentence |
denotes |
Scopus, Medline, and Web of Science was performed to identify studies reporting the rate of hypertension in COVID-19 patients with severe or non-severe disease or among survivors and non-survivors. |
| TextSentencer_T9 |
775-892 |
Sentence |
denotes |
The obtained data was pooled into a meta-analysis to calculate odds ratio (OR) with 95% confidence intervals (95%CI). |
| TextSentencer_T10 |
893-901 |
Sentence |
denotes |
RESULTS: |
| TextSentencer_T11 |
902-1013 |
Sentence |
denotes |
Hypertension was associated with a nearly 2.5-fold significantly increased risk of severe COVID-19 disease (OR: |
| TextSentencer_T12 |
1014-1026 |
Sentence |
denotes |
2.49 [95%CI: |
| TextSentencer_T13 |
1027-1116 |
Sentence |
denotes |
1.98-3.12] I2=24%), as well as with a similarly significant higher risk of mortality (OR: |
| TextSentencer_T14 |
1117-1129 |
Sentence |
denotes |
2.42 [95%CI: |
| TextSentencer_T15 |
1130-1148 |
Sentence |
denotes |
1.51-3.90] I2=0%). |
| TextSentencer_T16 |
1149-1343 |
Sentence |
denotes |
In meta-regression, a significant correlation was observed with an increase in mean age of patients with severe COVID-19 associated with increased log odds of hypertension and severity (p=0.03). |
| TextSentencer_T17 |
1344-1356 |
Sentence |
denotes |
CONCLUSIONS: |
| TextSentencer_T18 |
1357-1580 |
Sentence |
denotes |
The results of this pooled analysis of the current scientific literature would suggest that hypertension may be associated with an up to 2.5-fold higher risk of severe and fatal COVID-19, especially among older individuals. |
