Id |
Subject |
Object |
Predicate |
Lexical cue |
T0 |
0-15 |
NNS |
denotes |
Vulnerabilities |
T1 |
16-18 |
IN |
denotes |
in |
T2 |
19-30 |
NN |
denotes |
coronavirus |
T3 |
31-37 |
NN |
denotes |
glycan |
T4 |
38-45 |
NNS |
denotes |
shields |
T5 |
46-53 |
IN |
denotes |
despite |
T6 |
54-63 |
JJ |
denotes |
extensive |
T7 |
64-77 |
NN |
denotes |
glycosylation |
T8 |
79-87 |
NN |
denotes |
Abstract |
T9 |
88-94 |
JJ |
denotes |
Severe |
T10 |
95-100 |
JJ |
denotes |
acute |
T11 |
101-112 |
JJ |
denotes |
respiratory |
T12 |
113-121 |
NN |
denotes |
syndrome |
T13 |
122-123 |
-LRB- |
denotes |
( |
T14 |
123-127 |
NN |
denotes |
SARS |
T15 |
127-128 |
-RRB- |
denotes |
) |
T16 |
129-132 |
CC |
denotes |
and |
T17 |
133-139 |
NNP |
denotes |
Middle |
T18 |
140-144 |
NNP |
denotes |
East |
T19 |
145-156 |
JJ |
denotes |
respiratory |
T20 |
157-165 |
NN |
denotes |
syndrome |
T21 |
166-167 |
-LRB- |
denotes |
( |
T22 |
167-171 |
NNS |
denotes |
MERS |
T23 |
171-172 |
-RRB- |
denotes |
) |
T24 |
173-186 |
NNS |
denotes |
coronaviruses |
T25 |
187-188 |
-LRB- |
denotes |
( |
T26 |
188-192 |
NNS |
denotes |
CoVs |
T27 |
192-193 |
-RRB- |
denotes |
) |
T28 |
194-197 |
VBP |
denotes |
are |
T29 |
198-206 |
JJ |
denotes |
zoonotic |
T30 |
207-216 |
NNS |
denotes |
pathogens |
T31 |
217-221 |
IN |
denotes |
with |
T32 |
222-226 |
JJ |
denotes |
high |
T33 |
227-235 |
NN |
denotes |
fatality |
T34 |
236-241 |
NNS |
denotes |
rates |
T35 |
242-245 |
CC |
denotes |
and |
T36 |
246-254 |
JJ |
denotes |
pandemic |
T37 |
255-264 |
NN |
denotes |
potential |
T38 |
266-273 |
NN |
denotes |
Vaccine |
T39 |
274-285 |
NN |
denotes |
development |
T40 |
286-293 |
VBZ |
denotes |
focuses |
T41 |
294-296 |
IN |
denotes |
on |
T42 |
297-300 |
DT |
denotes |
the |
T43 |
301-310 |
JJ |
denotes |
principal |
T44 |
311-317 |
NN |
denotes |
target |
T45 |
318-320 |
IN |
denotes |
of |
T46 |
321-324 |
DT |
denotes |
the |
T47 |
325-337 |
VBG |
denotes |
neutralizing |
T48 |
338-345 |
JJ |
denotes |
humoral |
T49 |
346-352 |
JJ |
denotes |
immune |
T50 |
353-361 |
NN |
denotes |
response |
T51 |
361-362 |
-COMMA- |
denotes |
, |
T52 |
363-366 |
DT |
denotes |
the |
T53 |
367-372 |
NN |
denotes |
spike |
T54 |
373-374 |
-LRB- |
denotes |
( |
T55 |
374-375 |
NN |
denotes |
S |
T56 |
375-376 |
-RRB- |
denotes |
) |
T57 |
377-389 |
NN |
denotes |
glycoprotein |
T58 |
391-402 |
NN |
denotes |
Coronavirus |
T59 |
403-404 |
NN |
denotes |
S |
T60 |
405-413 |
NNS |
denotes |
proteins |
T61 |
414-417 |
VBP |
denotes |
are |
T62 |
418-429 |
RB |
denotes |
extensively |
T63 |
430-442 |
VBN |
denotes |
glycosylated |
T64 |
442-443 |
-COMMA- |
denotes |
, |
T65 |
444-452 |
VBG |
denotes |
encoding |
T66 |
453-459 |
IN |
denotes |
around |
T67 |
460-465 |
CD |
denotes |
66–87 |
T68 |
466-474 |
JJ |
denotes |
N-linked |
T69 |
475-488 |
NN |
denotes |
glycosylation |
T70 |
489-494 |
NNS |
denotes |
sites |
T71 |
495-498 |
IN |
denotes |
per |
T72 |
499-507 |
JJ |
denotes |
trimeric |
T73 |
508-513 |
NN |
denotes |
spike |
T74 |
515-519 |
RB |
denotes |
Here |
T75 |
519-520 |
-COMMA- |
denotes |
, |
T76 |
521-523 |
PRP |
denotes |
we |
T77 |
524-530 |
VBP |
denotes |
reveal |
T78 |
531-532 |
DT |
denotes |
a |
T79 |
533-541 |
JJ |
denotes |
specific |
T80 |
542-546 |
NN |
denotes |
area |
T81 |
547-549 |
IN |
denotes |
of |
T82 |
550-554 |
JJ |
denotes |
high |
T83 |
555-561 |
NN |
denotes |
glycan |
T84 |
562-569 |
NN |
denotes |
density |
T85 |
570-572 |
IN |
denotes |
on |
T86 |
573-577 |
NNP |
denotes |
MERS |
T87 |
578-579 |
NNP |
denotes |
S |
T88 |
580-584 |
WDT |
denotes |
that |
T89 |
585-592 |
VBZ |
denotes |
results |
T90 |
593-595 |
IN |
denotes |
in |
T91 |
596-599 |
DT |
denotes |
the |
T92 |
600-609 |
NN |
denotes |
formation |
T93 |
610-612 |
IN |
denotes |
of |
T94 |
613-630 |
JJ |
denotes |
oligomannose-type |
T95 |
631-637 |
NN |
denotes |
glycan |
T96 |
638-646 |
NNS |
denotes |
clusters |
T97 |
646-647 |
-COMMA- |
denotes |
, |
T98 |
648-653 |
WDT |
denotes |
which |
T99 |
654-658 |
VBD |
denotes |
were |
T100 |
659-665 |
JJ |
denotes |
absent |
T101 |
666-668 |
IN |
denotes |
on |
T102 |
669-673 |
NNS |
denotes |
SARS |
T103 |
674-677 |
CC |
denotes |
and |
T104 |
678-682 |
NN |
denotes |
HKU1 |
T105 |
683-687 |
NNS |
denotes |
CoVs |
T106 |
689-691 |
PRP |
denotes |
We |
T107 |
692-699 |
VBP |
denotes |
provide |
T108 |
700-701 |
DT |
denotes |
a |
T109 |
702-712 |
NN |
denotes |
comparison |
T110 |
713-715 |
IN |
denotes |
of |
T111 |
716-719 |
DT |
denotes |
the |
T112 |
720-726 |
JJ |
denotes |
global |
T113 |
727-733 |
NN |
denotes |
glycan |
T114 |
734-741 |
NN |
denotes |
density |
T115 |
742-744 |
IN |
denotes |
of |
T116 |
745-756 |
NN |
denotes |
coronavirus |
T117 |
757-763 |
NNS |
denotes |
spikes |
T118 |
764-768 |
IN |
denotes |
with |
T119 |
769-774 |
JJ |
denotes |
other |
T120 |
775-780 |
JJ |
denotes |
viral |
T121 |
781-789 |
NNS |
denotes |
proteins |
T122 |
790-799 |
VBG |
denotes |
including |
T123 |
800-805 |
NN |
denotes |
HIV-1 |
T124 |
806-814 |
NN |
denotes |
envelope |
T125 |
814-815 |
-COMMA- |
denotes |
, |
T126 |
816-821 |
NNP |
denotes |
Lassa |
T127 |
822-827 |
NN |
denotes |
virus |
T128 |
828-840 |
NN |
denotes |
glycoprotein |
T129 |
841-848 |
NN |
denotes |
complex |
T130 |
848-849 |
-COMMA- |
denotes |
, |
T131 |
850-853 |
CC |
denotes |
and |
T132 |
854-863 |
NN |
denotes |
influenza |
T133 |
864-877 |
NN |
denotes |
hemagglutinin |
T134 |
877-878 |
-COMMA- |
denotes |
, |
T135 |
879-884 |
WRB |
denotes |
where |
T136 |
885-898 |
NN |
denotes |
glycosylation |
T137 |
899-904 |
VBZ |
denotes |
plays |
T138 |
905-906 |
DT |
denotes |
a |
T139 |
907-912 |
VBN |
denotes |
known |
T140 |
913-917 |
NN |
denotes |
role |
T141 |
918-920 |
IN |
denotes |
in |
T142 |
921-930 |
VBG |
denotes |
shielding |
T143 |
931-942 |
JJ |
denotes |
immunogenic |
T144 |
943-951 |
NNS |
denotes |
epitopes |
T145 |
953-960 |
RB |
denotes |
Overall |
T146 |
960-961 |
-COMMA- |
denotes |
, |
T147 |
962-965 |
PRP-DOLLAR- |
denotes |
our |
T148 |
966-970 |
NNS |
denotes |
data |
T149 |
971-977 |
VBP |
denotes |
reveal |
T150 |
978-981 |
WRB |
denotes |
how |
T151 |
982-994 |
NN |
denotes |
organisation |
T152 |
995-997 |
IN |
denotes |
of |
T153 |
998-1011 |
NN |
denotes |
glycosylation |
T154 |
1012-1018 |
IN |
denotes |
across |
T155 |
1019-1024 |
NN |
denotes |
class |
T156 |
1025-1026 |
CD |
denotes |
I |
T157 |
1027-1032 |
JJ |
denotes |
viral |
T158 |
1033-1039 |
NN |
denotes |
fusion |
T159 |
1040-1048 |
NNS |
denotes |
proteins |
T160 |
1049-1058 |
VBP |
denotes |
influence |
T161 |
1059-1062 |
RB |
denotes |
not |
T162 |
1063-1067 |
RB |
denotes |
only |
T163 |
1068-1078 |
JJ |
denotes |
individual |
T164 |
1079-1085 |
NN |
denotes |
glycan |
T165 |
1086-1098 |
NNS |
denotes |
compositions |
T166 |
1099-1102 |
CC |
denotes |
but |
T167 |
1103-1107 |
RB |
denotes |
also |
T168 |
1108-1111 |
DT |
denotes |
the |
T169 |
1112-1125 |
JJ |
denotes |
immunological |
T170 |
1126-1134 |
NN |
denotes |
pressure |
T171 |
1135-1141 |
IN |
denotes |
across |
T172 |
1142-1145 |
DT |
denotes |
the |
T173 |
1146-1153 |
NN |
denotes |
protein |
T174 |
1154-1161 |
NN |
denotes |
surface |
T175 |
1164-1177 |
NN |
denotes |
Glycosylation |
T176 |
1178-1183 |
VBZ |
denotes |
plays |
T177 |
1184-1185 |
DT |
denotes |
a |
T178 |
1186-1189 |
JJ |
denotes |
key |
T179 |
1190-1194 |
NN |
denotes |
role |
T180 |
1195-1197 |
IN |
denotes |
in |
T181 |
1198-1207 |
NN |
denotes |
shielding |
T182 |
1208-1210 |
IN |
denotes |
of |
T183 |
1211-1222 |
JJ |
denotes |
immunogenic |
T184 |
1223-1231 |
NNS |
denotes |
epitopes |
T185 |
1232-1234 |
IN |
denotes |
on |
T186 |
1235-1240 |
JJ |
denotes |
viral |
T187 |
1241-1246 |
NN |
denotes |
spike |
T188 |
1247-1248 |
-LRB- |
denotes |
( |
T189 |
1248-1249 |
NN |
denotes |
S |
T190 |
1249-1250 |
-RRB- |
denotes |
) |
T191 |
1251-1259 |
NNS |
denotes |
proteins |
T192 |
1261-1265 |
RB |
denotes |
Here |
T193 |
1266-1274 |
NNP |
denotes |
Watanabe |
T194 |
1275-1277 |
FW |
denotes |
et |
T195 |
1278-1281 |
FW |
denotes |
al. |
T196 |
1282-1288 |
NN |
denotes |
report |
T197 |
1289-1293 |
IN |
denotes |
that |
T198 |
1294-1301 |
NNS |
denotes |
glycans |
T199 |
1302-1304 |
IN |
denotes |
of |
T200 |
1305-1316 |
NN |
denotes |
coronavirus |
T201 |
1317-1321 |
NNS |
denotes |
SARS |
T202 |
1322-1325 |
CC |
denotes |
and |
T203 |
1326-1330 |
NNP |
denotes |
MERS |
T204 |
1331-1332 |
NN |
denotes |
S |
T205 |
1333-1341 |
NNS |
denotes |
proteins |
T206 |
1342-1345 |
VBP |
denotes |
are |
T207 |
1346-1361 |
RB |
denotes |
heterogeneously |
T208 |
1362-1373 |
VBN |
denotes |
distributed |
T209 |
1374-1377 |
CC |
denotes |
and |
T210 |
1378-1380 |
VBP |
denotes |
do |
T211 |
1381-1384 |
RB |
denotes |
not |
T212 |
1385-1389 |
VB |
denotes |
form |
T213 |
1390-1392 |
DT |
denotes |
an |
T214 |
1393-1404 |
JJ |
denotes |
efficacious |
T215 |
1405-1417 |
JJ |
denotes |
high-density |
T216 |
1418-1424 |
JJ |
denotes |
global |
T217 |
1425-1431 |
NN |
denotes |
shield |
T218 |
1432-1437 |
WDT |
denotes |
which |
T219 |
1438-1443 |
MD |
denotes |
would |
T220 |
1444-1450 |
VB |
denotes |
ensure |
T221 |
1451-1460 |
JJ |
denotes |
efficient |
T222 |
1461-1467 |
JJ |
denotes |
immune |
T223 |
1468-1475 |
NN |
denotes |
evasion |
T224 |
1478-1490 |
NN |
denotes |
Introduction |
T225 |
1491-1504 |
NNS |
denotes |
Coronaviruses |
T226 |
1505-1506 |
-LRB- |
denotes |
( |
T227 |
1506-1510 |
NNS |
denotes |
CoVs |
T228 |
1510-1511 |
-RRB- |
denotes |
) |
T229 |
1512-1515 |
VBP |
denotes |
are |
T230 |
1516-1525 |
VBN |
denotes |
enveloped |
T231 |
1526-1535 |
NNS |
denotes |
pathogens |
T232 |
1536-1547 |
JJ |
denotes |
responsible |
T233 |
1548-1551 |
IN |
denotes |
for |
T234 |
1552-1560 |
JJ |
denotes |
multiple |
T235 |
1561-1572 |
JJ |
denotes |
respiratory |
T236 |
1573-1582 |
NNS |
denotes |
disorders |
T237 |
1583-1585 |
IN |
denotes |
of |
T238 |
1586-1593 |
VBG |
denotes |
varying |
T239 |
1594-1602 |
NN |
denotes |
severity |
T240 |
1603-1605 |
IN |
denotes |
in |
T241 |
1606-1613 |
NN |
denotes |
humans1 |
T242 |
1615-1622 |
JJ |
denotes |
Certain |
T243 |
1623-1627 |
NNS |
denotes |
CoVs |
T244 |
1628-1637 |
VBP |
denotes |
represent |
T245 |
1638-1639 |
DT |
denotes |
a |
T246 |
1640-1651 |
JJ |
denotes |
significant |
T247 |
1652-1658 |
NN |
denotes |
threat |
T248 |
1659-1661 |
TO |
denotes |
to |
T249 |
1662-1668 |
JJ |
denotes |
global |
T250 |
1669-1674 |
JJ |
denotes |
human |
T251 |
1675-1681 |
NN |
denotes |
health |
T252 |
1681-1682 |
-COMMA- |
denotes |
, |
T253 |
1683-1685 |
IN |
denotes |
as |
T254 |
1686-1697 |
VBN |
denotes |
illustrated |
T255 |
1698-1700 |
IN |
denotes |
by |
T256 |
1701-1710 |
NNS |
denotes |
outbreaks |
T257 |
1711-1713 |
IN |
denotes |
of |
T258 |
1714-1720 |
JJ |
denotes |
severe |
T259 |
1721-1726 |
JJ |
denotes |
acute |
T260 |
1727-1738 |
JJ |
denotes |
respiratory |
T261 |
1739-1747 |
NN |
denotes |
syndrome |
T262 |
1748-1759 |
NN |
denotes |
coronavirus |
T263 |
1760-1761 |
-LRB- |
denotes |
( |
T264 |
1761-1769 |
NN |
denotes |
SARS-CoV |
T265 |
1769-1770 |
-RRB- |
denotes |
) |
T266 |
1771-1773 |
IN |
denotes |
in |
T267 |
1774-1779 |
CD |
denotes |
20032 |
T268 |
1779-1780 |
-COMMA- |
denotes |
, |
T269 |
1781-1787 |
NNP |
denotes |
Middle |
T270 |
1788-1792 |
NNP |
denotes |
East |
T271 |
1793-1804 |
JJ |
denotes |
respiratory |
T272 |
1805-1813 |
NN |
denotes |
syndrome |
T273 |
1814-1825 |
NN |
denotes |
coronavirus |
T274 |
1826-1827 |
-LRB- |
denotes |
( |
T275 |
1827-1835 |
NN |
denotes |
MERS-CoV |
T276 |
1835-1836 |
-RRB- |
denotes |
) |
T277 |
1837-1839 |
IN |
denotes |
in |
T278 |
1840-1845 |
CD |
denotes |
20123 |
T279 |
1845-1846 |
-COMMA- |
denotes |
, |
T280 |
1847-1850 |
CC |
denotes |
and |
T281 |
1851-1855 |
RBS |
denotes |
most |
T282 |
1856-1864 |
RB |
denotes |
recently |
T283 |
1865-1867 |
IN |
denotes |
of |
T284 |
1868-1879 |
NN |
denotes |
SARS-CoV-24 |
T285 |
1881-1886 |
VBN |
denotes |
Given |
T286 |
1887-1892 |
PRP-DOLLAR- |
denotes |
their |
T287 |
1893-1902 |
NN |
denotes |
mortality |
T288 |
1903-1908 |
NNS |
denotes |
rates |
T289 |
1908-1909 |
-COMMA- |
denotes |
, |
T290 |
1910-1913 |
DT |
denotes |
the |
T291 |
1914-1921 |
JJ |
denotes |
current |
T292 |
1922-1926 |
NN |
denotes |
lack |
T293 |
1927-1929 |
IN |
denotes |
of |
T294 |
1930-1938 |
VBN |
denotes |
targeted |
T295 |
1939-1949 |
NNS |
denotes |
treatments |
T296 |
1950-1953 |
CC |
denotes |
and |
T297 |
1954-1962 |
JJ |
denotes |
licensed |
T298 |
1963-1971 |
NNS |
denotes |
vaccines |
T299 |
1971-1972 |
-COMMA- |
denotes |
, |
T300 |
1973-1976 |
CC |
denotes |
and |
T301 |
1977-1982 |
PRP-DOLLAR- |
denotes |
their |
T302 |
1983-1991 |
NN |
denotes |
capacity |
T303 |
1992-1994 |
TO |
denotes |
to |
T304 |
1995-2003 |
VB |
denotes |
transmit |
T305 |
2004-2011 |
IN |
denotes |
between |
T306 |
2012-2018 |
NNS |
denotes |
humans |
T307 |
2019-2022 |
CC |
denotes |
and |
T308 |
2023-2029 |
IN |
denotes |
across |
T309 |
2030-2037 |
NNS |
denotes |
species |
T310 |
2038-2049 |
NN |
denotes |
barriers5,6 |
T311 |
2049-2050 |
-COMMA- |
denotes |
, |
T312 |
2051-2056 |
EX |
denotes |
there |
T313 |
2057-2059 |
VBZ |
denotes |
is |
T314 |
2060-2062 |
DT |
denotes |
an |
T315 |
2063-2069 |
JJ |
denotes |
urgent |
T316 |
2070-2074 |
NN |
denotes |
need |
T317 |
2075-2078 |
IN |
denotes |
for |
T318 |
2079-2088 |
JJ |
denotes |
effective |
T319 |
2089-2104 |
NNS |
denotes |
countermeasures |
T320 |
2105-2107 |
TO |
denotes |
to |
T321 |
2108-2114 |
VB |
denotes |
combat |
T322 |
2115-2120 |
DT |
denotes |
these |
T323 |
2121-2130 |
NNS |
denotes |
pathogens |
T324 |
2132-2139 |
VBG |
denotes |
Ongoing |
T325 |
2140-2147 |
NN |
denotes |
vaccine |
T326 |
2148-2159 |
NN |
denotes |
development |
T327 |
2160-2167 |
NNS |
denotes |
efforts |
T328 |
2168-2173 |
NN |
denotes |
focus |
T329 |
2174-2176 |
IN |
denotes |
on |
T330 |
2177-2180 |
DT |
denotes |
the |
T331 |
2181-2186 |
NN |
denotes |
spike |
T332 |
2187-2188 |
-LRB- |
denotes |
( |
T333 |
2188-2189 |
NN |
denotes |
S |
T334 |
2189-2190 |
-RRB- |
denotes |
) |
T335 |
2191-2199 |
NNS |
denotes |
proteins |
T336 |
2200-2204 |
WDT |
denotes |
that |
T337 |
2205-2213 |
VBP |
denotes |
protrude |
T338 |
2214-2218 |
IN |
denotes |
from |
T339 |
2219-2222 |
DT |
denotes |
the |
T340 |
2223-2228 |
JJ |
denotes |
viral |
T341 |
2229-2237 |
NN |
denotes |
envelope |
T342 |
2238-2241 |
CC |
denotes |
and |
T343 |
2242-2252 |
VB |
denotes |
constitute |
T344 |
2253-2256 |
DT |
denotes |
the |
T345 |
2257-2261 |
JJ |
denotes |
main |
T346 |
2262-2268 |
NN |
denotes |
target |
T347 |
2269-2271 |
IN |
denotes |
of |
T348 |
2272-2284 |
VBG |
denotes |
neutralizing |
T349 |
2285-2298 |
NN |
denotes |
antibodies7,8 |
T350 |
2300-2305 |
DT |
denotes |
These |
T351 |
2306-2314 |
JJ |
denotes |
trimeric |
T352 |
2315-2316 |
NN |
denotes |
S |
T353 |
2317-2325 |
NNS |
denotes |
proteins |
T354 |
2326-2333 |
VBP |
denotes |
mediate |
T355 |
2334-2343 |
JJ |
denotes |
host-cell |
T356 |
2344-2349 |
NN |
denotes |
entry |
T357 |
2350-2354 |
IN |
denotes |
with |
T358 |
2355-2358 |
DT |
denotes |
the |
T359 |
2359-2361 |
NN |
denotes |
S1 |
T360 |
2362-2365 |
CC |
denotes |
and |
T361 |
2366-2368 |
NN |
denotes |
S2 |
T362 |
2369-2377 |
NNS |
denotes |
subunits |
T363 |
2378-2389 |
JJ |
denotes |
responsible |
T364 |
2390-2393 |
IN |
denotes |
for |
T365 |
2394-2401 |
VBG |
denotes |
binding |
T366 |
2402-2404 |
TO |
denotes |
to |
T367 |
2405-2408 |
DT |
denotes |
the |
T368 |
2409-2418 |
NN |
denotes |
host-cell |
T369 |
2419-2427 |
NN |
denotes |
receptor |
T370 |
2428-2431 |
CC |
denotes |
and |
T371 |
2432-2444 |
VBG |
denotes |
facilitating |
T372 |
2445-2453 |
NN |
denotes |
membrane |
T373 |
2454-2460 |
NN |
denotes |
fusion |
T374 |
2460-2461 |
-COMMA- |
denotes |
, |
T375 |
2462-2478 |
NN |
denotes |
respectively9–11 |
T376 |
2480-2484 |
NNS |
denotes |
MERS |
T377 |
2485-2486 |
NN |
denotes |
S |
T378 |
2487-2492 |
VBZ |
denotes |
binds |
T379 |
2493-2495 |
TO |
denotes |
to |
T380 |
2496-2516 |
NN |
denotes |
dipeptidyl-peptidase |
T381 |
2517-2518 |
CD |
denotes |
4 |
T382 |
2519-2520 |
-LRB- |
denotes |
( |
T383 |
2520-2524 |
NN |
denotes |
DPP4 |
T384 |
2524-2525 |
-RRB- |
denotes |
) |
T385 |
2525-2527 |
CD |
denotes |
12 |
T386 |
2527-2528 |
-COMMA- |
denotes |
, |
T387 |
2529-2536 |
IN |
denotes |
whereas |
T388 |
2537-2541 |
NN |
denotes |
SARS |
T389 |
2542-2545 |
NN |
denotes |
S13 |
T390 |
2546-2549 |
CC |
denotes |
and |
T391 |
2550-2565 |
NN |
denotes |
SARS-CoV-214,15 |
T392 |
2566-2573 |
VBP |
denotes |
utilize |
T393 |
2574-2596 |
JJ |
denotes |
angiotensin-converting |
T394 |
2597-2603 |
NN |
denotes |
enzyme |
T395 |
2604-2605 |
CD |
denotes |
2 |
T396 |
2606-2607 |
-LRB- |
denotes |
( |
T397 |
2607-2611 |
NN |
denotes |
ACE2 |
T398 |
2611-2612 |
-RRB- |
denotes |
) |
T399 |
2613-2615 |
IN |
denotes |
as |
T400 |
2616-2617 |
DT |
denotes |
a |
T401 |
2618-2622 |
NN |
denotes |
host |
T402 |
2623-2631 |
JJ |
denotes |
cellular |
T403 |
2632-2640 |
NN |
denotes |
receptor |
T404 |
2642-2645 |
NN |
denotes |
CoV |
T405 |
2646-2647 |
NN |
denotes |
S |
T406 |
2648-2656 |
NNS |
denotes |
proteins |
T407 |
2657-2660 |
VBP |
denotes |
are |
T408 |
2661-2664 |
DT |
denotes |
the |
T409 |
2665-2672 |
JJS |
denotes |
largest |
T410 |
2673-2678 |
NN |
denotes |
class |
T411 |
2679-2680 |
CD |
denotes |
I |
T412 |
2681-2686 |
JJ |
denotes |
viral |
T413 |
2687-2693 |
NN |
denotes |
fusion |
T414 |
2694-2702 |
NNS |
denotes |
proteins |
T415 |
2703-2709 |
NN |
denotes |
known9 |
T416 |
2709-2710 |
-COMMA- |
denotes |
, |
T417 |
2711-2714 |
CC |
denotes |
and |
T418 |
2715-2718 |
VBP |
denotes |
are |
T419 |
2719-2730 |
RB |
denotes |
extensively |
T420 |
2731-2743 |
VBN |
denotes |
glycosylated |
T421 |
2743-2744 |
-COMMA- |
denotes |
, |
T422 |
2745-2749 |
IN |
denotes |
with |
T423 |
2750-2754 |
NNP |
denotes |
SARS |
T424 |
2755-2758 |
CC |
denotes |
and |
T425 |
2759-2763 |
NNP |
denotes |
MERS |
T426 |
2764-2765 |
NN |
denotes |
S |
T427 |
2766-2779 |
NNS |
denotes |
glycoproteins |
T428 |
2780-2784 |
CC |
denotes |
both |
T429 |
2785-2793 |
VBG |
denotes |
encoding |
T430 |
2794-2796 |
CD |
denotes |
69 |
T431 |
2797-2805 |
JJ |
denotes |
N-linked |
T432 |
2806-2812 |
NN |
denotes |
glycan |
T433 |
2813-2820 |
NNS |
denotes |
sequons |
T434 |
2821-2824 |
IN |
denotes |
per |
T435 |
2825-2833 |
JJ |
denotes |
trimeric |
T436 |
2834-2839 |
NN |
denotes |
spike |
T437 |
2840-2844 |
IN |
denotes |
with |
T438 |
2845-2855 |
NN |
denotes |
SARS-CoV-2 |
T439 |
2856-2866 |
VBG |
denotes |
containing |
T440 |
2867-2869 |
CD |
denotes |
66 |
T441 |
2870-2875 |
NNS |
denotes |
sites |
T442 |
2877-2882 |
DT |
denotes |
These |
T443 |
2883-2896 |
NNS |
denotes |
modifications |
T444 |
2897-2902 |
RB |
denotes |
often |
T445 |
2903-2907 |
VBP |
denotes |
mask |
T446 |
2908-2919 |
JJ |
denotes |
immunogenic |
T447 |
2920-2927 |
NN |
denotes |
protein |
T448 |
2928-2936 |
NNS |
denotes |
epitopes |
T449 |
2937-2941 |
IN |
denotes |
from |
T450 |
2942-2945 |
DT |
denotes |
the |
T451 |
2946-2950 |
NN |
denotes |
host |
T452 |
2951-2958 |
JJ |
denotes |
humoral |
T453 |
2959-2965 |
JJ |
denotes |
immune |
T454 |
2966-2972 |
NN |
denotes |
system |
T455 |
2973-2975 |
IN |
denotes |
by |
T456 |
2976-2985 |
VBG |
denotes |
occluding |
T457 |
2986-2990 |
PRP |
denotes |
them |
T458 |
2991-2995 |
IN |
denotes |
with |
T459 |
2996-3008 |
JJ |
denotes |
host-derived |
T460 |
3009-3021 |
NN |
denotes |
glycans16–18 |
T461 |
3023-3027 |
DT |
denotes |
This |
T462 |
3028-3038 |
NN |
denotes |
phenomenon |
T463 |
3039-3041 |
IN |
denotes |
of |
T464 |
3042-3048 |
JJ |
denotes |
immune |
T465 |
3049-3056 |
NN |
denotes |
evasion |
T466 |
3057-3059 |
IN |
denotes |
by |
T467 |
3060-3069 |
JJ |
denotes |
molecular |
T468 |
3070-3077 |
NN |
denotes |
mimicry |
T469 |
3078-3081 |
CC |
denotes |
and |
T470 |
3082-3088 |
NN |
denotes |
glycan |
T471 |
3089-3098 |
NN |
denotes |
shielding |
T472 |
3099-3102 |
VBZ |
denotes |
has |
T473 |
3103-3107 |
VBN |
denotes |
been |
T474 |
3108-3112 |
RB |
denotes |
well |
T475 |
3113-3126 |
VBN |
denotes |
characterised |
T476 |
3127-3133 |
IN |
denotes |
across |
T477 |
3134-3139 |
JJ |
denotes |
other |
T478 |
3140-3145 |
JJ |
denotes |
viral |
T479 |
3146-3159 |
NNS |
denotes |
glycoproteins |
T480 |
3159-3160 |
-COMMA- |
denotes |
, |
T481 |
3161-3165 |
JJ |
denotes |
such |
T482 |
3166-3168 |
IN |
denotes |
as |
T483 |
3169-3174 |
NN |
denotes |
HIV-1 |
T484 |
3175-3183 |
NN |
denotes |
envelope |
T485 |
3184-3191 |
NN |
denotes |
protein |
T486 |
3192-3193 |
-LRB- |
denotes |
( |
T487 |
3193-3196 |
NN |
denotes |
Env |
T488 |
3196-3197 |
-RRB- |
denotes |
) |
T489 |
3197-3202 |
CD |
denotes |
19–21 |
T490 |
3202-3203 |
-COMMA- |
denotes |
, |
T491 |
3204-3213 |
NN |
denotes |
influenza |
T492 |
3214-3227 |
NN |
denotes |
hemagglutinin |
T493 |
3228-3229 |
-LRB- |
denotes |
( |
T494 |
3229-3231 |
NN |
denotes |
HA |
T495 |
3231-3232 |
-RRB- |
denotes |
) |
T496 |
3232-3237 |
CD |
denotes |
22,23 |
T497 |
3238-3241 |
CC |
denotes |
and |
T498 |
3242-3247 |
NNP |
denotes |
Lassa |
T499 |
3248-3253 |
NN |
denotes |
virus |
T500 |
3254-3266 |
NN |
denotes |
glycoprotein |
T501 |
3267-3274 |
NN |
denotes |
complex |
T502 |
3275-3276 |
-LRB- |
denotes |
( |
T503 |
3276-3280 |
NN |
denotes |
LASV |
T504 |
3281-3284 |
NN |
denotes |
GPC |
T505 |
3284-3285 |
-RRB- |
denotes |
) |
T506 |
3285-3290 |
CD |
denotes |
24–26 |
T507 |
3292-3300 |
JJ |
denotes |
Previous |
T508 |
3301-3309 |
NNS |
denotes |
analyses |
T509 |
3310-3312 |
IN |
denotes |
of |
T510 |
3313-3318 |
JJ |
denotes |
viral |
T511 |
3319-3325 |
NN |
denotes |
glycan |
T512 |
3326-3333 |
NNS |
denotes |
shields |
T513 |
3334-3338 |
VBP |
denotes |
have |
T514 |
3339-3347 |
VBN |
denotes |
revealed |
T515 |
3348-3351 |
DT |
denotes |
the |
T516 |
3352-3360 |
NN |
denotes |
presence |
T517 |
3361-3363 |
IN |
denotes |
of |
T518 |
3364-3378 |
JJ |
denotes |
underprocessed |
T519 |
3379-3396 |
JJ |
denotes |
oligomannose-type |
T520 |
3397-3404 |
NNS |
denotes |
glycans |
T521 |
3405-3409 |
WDT |
denotes |
that |
T522 |
3410-3419 |
RB |
denotes |
seemingly |
T523 |
3420-3425 |
VBP |
denotes |
arise |
T524 |
3426-3429 |
JJ |
denotes |
due |
T525 |
3430-3432 |
TO |
denotes |
to |
T526 |
3433-3439 |
JJ |
denotes |
steric |
T527 |
3440-3451 |
NNS |
denotes |
constraints |
T528 |
3452-3456 |
WDT |
denotes |
that |
T529 |
3457-3464 |
VBP |
denotes |
prevent |
T530 |
3465-3471 |
NN |
denotes |
access |
T531 |
3472-3474 |
IN |
denotes |
of |
T532 |
3475-3481 |
NN |
denotes |
glycan |
T533 |
3482-3492 |
NN |
denotes |
processing |
T534 |
3493-3500 |
NNS |
denotes |
enzymes |
T535 |
3501-3503 |
TO |
denotes |
to |
T536 |
3504-3513 |
NN |
denotes |
substrate |
T537 |
3514-3529 |
NN |
denotes |
glycans24,27,28 |
T538 |
3529-3530 |
-COMMA- |
denotes |
, |
T539 |
3531-3541 |
RB |
denotes |
especially |
T540 |
3542-3546 |
WRB |
denotes |
when |
T541 |
3547-3550 |
DT |
denotes |
the |
T542 |
3551-3556 |
JJ |
denotes |
viral |
T543 |
3557-3569 |
NN |
denotes |
glycoprotein |
T544 |
3570-3573 |
VBZ |
denotes |
has |
T545 |
3574-3581 |
VBN |
denotes |
evolved |
T546 |
3582-3584 |
TO |
denotes |
to |
T547 |
3585-3589 |
VB |
denotes |
mask |
T548 |
3590-3601 |
JJ |
denotes |
immunogenic |
T549 |
3602-3610 |
NNS |
denotes |
epitopes |
T550 |
3611-3615 |
IN |
denotes |
with |
T551 |
3616-3617 |
DT |
denotes |
a |
T552 |
3618-3630 |
RB |
denotes |
particularly |
T553 |
3631-3636 |
JJ |
denotes |
dense |
T554 |
3637-3642 |
NN |
denotes |
array |
T555 |
3643-3645 |
IN |
denotes |
of |
T556 |
3646-3658 |
JJ |
denotes |
host-derived |
T557 |
3659-3674 |
NN |
denotes |
glycans26,29–34 |
T558 |
3676-3686 |
JJ |
denotes |
Restricted |
T559 |
3687-3693 |
NN |
denotes |
access |
T560 |
3694-3696 |
TO |
denotes |
to |
T561 |
3697-3702 |
DT |
denotes |
these |
T562 |
3703-3709 |
NN |
denotes |
glycan |
T563 |
3710-3715 |
NNS |
denotes |
sites |
T564 |
3716-3718 |
CC |
denotes |
or |
T565 |
3719-3731 |
NN |
denotes |
interference |
T566 |
3732-3736 |
IN |
denotes |
with |
T567 |
3737-3748 |
VBG |
denotes |
surrounding |
T568 |
3749-3756 |
NN |
denotes |
protein |
T569 |
3757-3764 |
NN |
denotes |
surface |
T570 |
3765-3767 |
CC |
denotes |
or |
T571 |
3768-3780 |
VBG |
denotes |
neighbouring |
T572 |
3781-3787 |
NN |
denotes |
glycan |
T573 |
3788-3796 |
NNS |
denotes |
residues |
T574 |
3797-3800 |
MD |
denotes |
can |
T575 |
3801-3807 |
VB |
denotes |
render |
T576 |
3808-3814 |
NN |
denotes |
glycan |
T577 |
3815-3825 |
NN |
denotes |
processing |
T578 |
3826-3833 |
NNS |
denotes |
enzymes |
T579 |
3834-3845 |
JJ |
denotes |
ineffective |
T580 |
3846-3848 |
IN |
denotes |
in |
T581 |
3849-3857 |
JJ |
denotes |
specific |
T582 |
3858-3873 |
NN |
denotes |
regions27,28,35 |
T583 |
3875-3881 |
NN |
denotes |
Glycan |
T584 |
3882-3892 |
NN |
denotes |
processing |
T585 |
3893-3895 |
IN |
denotes |
on |
T586 |
3896-3903 |
JJ |
denotes |
soluble |
T587 |
3904-3917 |
NNS |
denotes |
glycoproteins |
T588 |
3918-3921 |
VBZ |
denotes |
has |
T589 |
3922-3926 |
RB |
denotes |
also |
T590 |
3927-3931 |
VBN |
denotes |
been |
T591 |
3932-3937 |
VBN |
denotes |
shown |
T592 |
3938-3940 |
TO |
denotes |
to |
T593 |
3941-3943 |
VB |
denotes |
be |
T594 |
3944-3945 |
DT |
denotes |
a |
T595 |
3946-3952 |
JJ |
denotes |
strong |
T596 |
3953-3961 |
NN |
denotes |
reporter |
T597 |
3962-3964 |
IN |
denotes |
of |
T598 |
3965-3976 |
JJ |
denotes |
native-like |
T599 |
3977-3984 |
NN |
denotes |
protein |
T600 |
3985-3997 |
NN |
denotes |
architecture |
T601 |
3998-4001 |
CC |
denotes |
and |
T602 |
4002-4006 |
RB |
denotes |
thus |
T603 |
4007-4016 |
NN |
denotes |
immunogen |
T604 |
4017-4031 |
NN |
denotes |
integrity36–38 |
T605 |
4031-4032 |
-SEMICOLON- |
denotes |
; |
T606 |
4033-4036 |
CC |
denotes |
and |
T607 |
4037-4043 |
NN |
denotes |
glycan |
T608 |
4044-4054 |
NN |
denotes |
processing |
T609 |
4055-4057 |
IN |
denotes |
on |
T610 |
4058-4059 |
DT |
denotes |
a |
T611 |
4060-4070 |
JJ |
denotes |
successful |
T612 |
4071-4080 |
NN |
denotes |
immunogen |
T613 |
4081-4090 |
NN |
denotes |
candidate |
T614 |
4091-4097 |
MD |
denotes |
should |
T615 |
4098-4107 |
RB |
denotes |
therefore |
T616 |
4108-4113 |
VB |
denotes |
mimic |
T617 |
4113-4114 |
-COMMA- |
denotes |
, |
T618 |
4115-4117 |
RB |
denotes |
as |
T619 |
4118-4125 |
RB |
denotes |
closely |
T620 |
4126-4128 |
IN |
denotes |
as |
T621 |
4129-4137 |
JJ |
denotes |
possible |
T622 |
4137-4138 |
-COMMA- |
denotes |
, |
T623 |
4139-4142 |
DT |
denotes |
the |
T624 |
4143-4153 |
JJ |
denotes |
structural |
T625 |
4154-4162 |
NNS |
denotes |
features |
T626 |
4163-4171 |
VBN |
denotes |
observed |
T627 |
4172-4174 |
IN |
denotes |
on |
T628 |
4175-4178 |
DT |
denotes |
the |
T629 |
4179-4185 |
JJ |
denotes |
native |
T630 |
4186-4196 |
NN |
denotes |
virus39,40 |
T631 |
4198-4202 |
RB |
denotes |
Here |
T632 |
4202-4203 |
-COMMA- |
denotes |
, |
T633 |
4204-4206 |
PRP |
denotes |
we |
T634 |
4207-4214 |
VBP |
denotes |
provide |
T635 |
4215-4221 |
JJ |
denotes |
global |
T636 |
4222-4225 |
CC |
denotes |
and |
T637 |
4226-4239 |
JJ |
denotes |
site-specific |
T638 |
4240-4248 |
NNS |
denotes |
analyses |
T639 |
4249-4251 |
IN |
denotes |
of |
T640 |
4252-4260 |
JJ |
denotes |
N-linked |
T641 |
4261-4274 |
NN |
denotes |
glycosylation |
T642 |
4275-4277 |
IN |
denotes |
on |
T643 |
4278-4285 |
JJ |
denotes |
soluble |
T644 |
4286-4290 |
NNS |
denotes |
SARS |
T645 |
4290-4291 |
-COMMA- |
denotes |
, |
T646 |
4292-4296 |
NNS |
denotes |
MERS |
T647 |
4297-4300 |
CC |
denotes |
and |
T648 |
4301-4305 |
NN |
denotes |
HKU1 |
T649 |
4306-4309 |
NN |
denotes |
CoV |
T650 |
4310-4311 |
NN |
denotes |
S |
T651 |
4312-4325 |
NNS |
denotes |
glycoproteins |
T652 |
4326-4329 |
CC |
denotes |
and |
T653 |
4330-4336 |
VB |
denotes |
reveal |
T654 |
4337-4346 |
JJ |
denotes |
extensive |
T655 |
4347-4360 |
NN |
denotes |
heterogeneity |
T656 |
4360-4361 |
-COMMA- |
denotes |
, |
T657 |
4362-4369 |
VBG |
denotes |
ranging |
T658 |
4370-4374 |
IN |
denotes |
from |
T659 |
4375-4392 |
JJ |
denotes |
oligomannose-type |
T660 |
4393-4400 |
NNS |
denotes |
glycans |
T661 |
4401-4403 |
TO |
denotes |
to |
T662 |
4404-4420 |
JJ |
denotes |
highly-processed |
T663 |
4421-4433 |
JJ |
denotes |
complex-type |
T664 |
4434-4447 |
NN |
denotes |
glycosylation |
T665 |
4449-4452 |
DT |
denotes |
The |
T666 |
4453-4463 |
JJ |
denotes |
structural |
T667 |
4464-4471 |
NN |
denotes |
mapping |
T668 |
4472-4474 |
IN |
denotes |
of |
T669 |
4475-4482 |
NNS |
denotes |
glycans |
T670 |
4483-4485 |
IN |
denotes |
of |
T671 |
4486-4494 |
JJ |
denotes |
trimeric |
T672 |
4495-4496 |
NN |
denotes |
S |
T673 |
4497-4505 |
NNS |
denotes |
proteins |
T674 |
4506-4514 |
VBD |
denotes |
revealed |
T675 |
4515-4519 |
IN |
denotes |
that |
T676 |
4520-4524 |
DT |
denotes |
some |
T677 |
4525-4527 |
IN |
denotes |
of |
T678 |
4528-4533 |
DT |
denotes |
these |
T679 |
4534-4541 |
NNS |
denotes |
glycans |
T680 |
4542-4552 |
VBP |
denotes |
contribute |
T681 |
4553-4555 |
TO |
denotes |
to |
T682 |
4556-4559 |
DT |
denotes |
the |
T683 |
4560-4569 |
NN |
denotes |
formation |
T684 |
4570-4572 |
IN |
denotes |
of |
T685 |
4573-4574 |
DT |
denotes |
a |
T686 |
4575-4582 |
NN |
denotes |
cluster |
T687 |
4583-4585 |
IN |
denotes |
of |
T688 |
4586-4603 |
JJ |
denotes |
oligomannose-type |
T689 |
4604-4611 |
NNS |
denotes |
glycans |
T690 |
4612-4614 |
IN |
denotes |
at |
T691 |
4615-4623 |
JJ |
denotes |
specific |
T692 |
4624-4631 |
NNS |
denotes |
regions |
T693 |
4632-4634 |
IN |
denotes |
of |
T694 |
4635-4639 |
JJ |
denotes |
high |
T695 |
4640-4646 |
NN |
denotes |
glycan |
T696 |
4647-4654 |
NN |
denotes |
density |
T697 |
4655-4657 |
IN |
denotes |
on |
T698 |
4658-4666 |
NNP |
denotes |
MERS-CoV |
T699 |
4667-4669 |
NNP |
denotes |
S. |
T700 |
4670-4679 |
NNP |
denotes |
Molecular |
T701 |
4680-4689 |
NN |
denotes |
evolution |
T702 |
4690-4698 |
NN |
denotes |
analysis |
T703 |
4699-4701 |
IN |
denotes |
of |
T704 |
4702-4706 |
NNP |
denotes |
SARS |
T705 |
4707-4710 |
CC |
denotes |
and |
T706 |
4711-4715 |
NNP |
denotes |
MERS |
T707 |
4716-4717 |
NN |
denotes |
S |
T708 |
4718-4723 |
NNS |
denotes |
genes |
T709 |
4724-4728 |
RB |
denotes |
also |
T710 |
4729-4736 |
VBZ |
denotes |
reveals |
T711 |
4737-4738 |
DT |
denotes |
a |
T712 |
4739-4745 |
JJR |
denotes |
higher |
T713 |
4746-4755 |
NN |
denotes |
incidence |
T714 |
4756-4758 |
IN |
denotes |
of |
T715 |
4759-4769 |
JJ |
denotes |
amino-acid |
T716 |
4770-4779 |
NN |
denotes |
diversity |
T717 |
4780-4782 |
IN |
denotes |
on |
T718 |
4783-4786 |
DT |
denotes |
the |
T719 |
4787-4794 |
VBN |
denotes |
exposed |
T720 |
4795-4803 |
NNS |
denotes |
surfaces |
T721 |
4804-4806 |
IN |
denotes |
of |
T722 |
4807-4810 |
DT |
denotes |
the |
T723 |
4811-4812 |
NN |
denotes |
S |
T724 |
4813-4821 |
NNS |
denotes |
proteins |
T725 |
4822-4826 |
WDT |
denotes |
that |
T726 |
4827-4830 |
VBP |
denotes |
are |
T727 |
4831-4834 |
RB |
denotes |
not |
T728 |
4835-4843 |
VBN |
denotes |
occluded |
T729 |
4844-4846 |
IN |
denotes |
by |
T730 |
4847-4855 |
JJ |
denotes |
N-linked |
T731 |
4856-4863 |
NNS |
denotes |
glycans |
T732 |
4865-4867 |
IN |
denotes |
In |
T733 |
4868-4876 |
NN |
denotes |
addition |
T734 |
4876-4877 |
-COMMA- |
denotes |
, |
T735 |
4878-4880 |
PRP |
denotes |
we |
T736 |
4881-4888 |
VBP |
denotes |
compare |
T737 |
4889-4892 |
DT |
denotes |
the |
T738 |
4893-4903 |
NNS |
denotes |
structures |
T739 |
4904-4906 |
IN |
denotes |
of |
T740 |
4907-4910 |
DT |
denotes |
the |
T741 |
4911-4921 |
JJ |
denotes |
respective |
T742 |
4922-4928 |
NN |
denotes |
glycan |
T743 |
4929-4934 |
NNS |
denotes |
coats |
T744 |
4935-4937 |
IN |
denotes |
of |
T745 |
4938-4942 |
NN |
denotes |
SARS |
T746 |
4943-4946 |
CC |
denotes |
and |
T747 |
4947-4952 |
NN |
denotes |
HIV-1 |
T748 |
4953-4961 |
NN |
denotes |
envelope |
T749 |
4962-4970 |
NNS |
denotes |
proteins |
T750 |
4971-4976 |
VBG |
denotes |
using |
T751 |
4977-4990 |
NN |
denotes |
cryo-electron |
T752 |
4991-5001 |
NN |
denotes |
microscopy |
T753 |
5002-5003 |
-LRB- |
denotes |
( |
T754 |
5003-5010 |
NN |
denotes |
cryo-EM |
T755 |
5010-5011 |
-RRB- |
denotes |
) |
T756 |
5012-5015 |
CC |
denotes |
and |
T757 |
5016-5029 |
JJ |
denotes |
computational |
T758 |
5030-5039 |
NN |
denotes |
modelling |
T759 |
5039-5040 |
-COMMA- |
denotes |
, |
T760 |
5041-5046 |
WDT |
denotes |
which |
T761 |
5047-5056 |
VBP |
denotes |
delineate |
T762 |
5057-5058 |
DT |
denotes |
a |
T763 |
5059-5065 |
JJ |
denotes |
sparse |
T764 |
5066-5072 |
NN |
denotes |
glycan |
T765 |
5073-5079 |
NN |
denotes |
shield |
T766 |
5080-5089 |
VBD |
denotes |
exhibited |
T767 |
5090-5092 |
IN |
denotes |
on |
T768 |
5093-5097 |
NNP |
denotes |
SARS |
T769 |
5098-5099 |
NN |
denotes |
S |
T770 |
5100-5108 |
VBN |
denotes |
compared |
T771 |
5109-5113 |
IN |
denotes |
with |
T772 |
5114-5119 |
JJ |
denotes |
other |
T773 |
5120-5125 |
JJ |
denotes |
viral |
T774 |
5126-5139 |
NNS |
denotes |
glycoproteins |
T775 |
5141-5143 |
PRP |
denotes |
We |
T776 |
5144-5153 |
RB |
denotes |
therefore |
T777 |
5154-5163 |
VBD |
denotes |
undertook |
T778 |
5164-5165 |
DT |
denotes |
a |
T779 |
5166-5177 |
JJ |
denotes |
comparative |
T780 |
5178-5186 |
NN |
denotes |
analysis |
T781 |
5187-5189 |
IN |
denotes |
of |
T782 |
5190-5195 |
JJ |
denotes |
viral |
T783 |
5196-5202 |
NN |
denotes |
glycan |
T784 |
5203-5210 |
NNS |
denotes |
shields |
T785 |
5211-5215 |
IN |
denotes |
from |
T786 |
5216-5229 |
VBN |
denotes |
characterized |
T787 |
5230-5235 |
NN |
denotes |
class |
T788 |
5236-5237 |
CD |
denotes |
I |
T789 |
5238-5244 |
NN |
denotes |
fusion |
T790 |
5245-5253 |
NNS |
denotes |
proteins |
T791 |
5254-5256 |
TO |
denotes |
to |
T792 |
5257-5266 |
VB |
denotes |
highlight |
T793 |
5267-5270 |
WRB |
denotes |
how |
T794 |
5271-5284 |
NN |
denotes |
glycosylation |
T795 |
5285-5292 |
NN |
denotes |
density |
T796 |
5293-5303 |
VBZ |
denotes |
influences |
T797 |
5304-5321 |
JJ |
denotes |
oligomannose-type |
T798 |
5322-5328 |
NN |
denotes |
glycan |
T799 |
5329-5338 |
NN |
denotes |
abundance |
T800 |
5338-5339 |
-COMMA- |
denotes |
, |
T801 |
5340-5343 |
CC |
denotes |
and |
T802 |
5344-5347 |
DT |
denotes |
the |
T803 |
5348-5360 |
NN |
denotes |
relationship |
T804 |
5361-5368 |
IN |
denotes |
between |
T805 |
5369-5378 |
JJ |
denotes |
effective |
T806 |
5379-5385 |
NN |
denotes |
glycan |
T807 |
5386-5393 |
NNS |
denotes |
shields |
T808 |
5394-5397 |
CC |
denotes |
and |
T809 |
5398-5403 |
JJ |
denotes |
viral |
T810 |
5404-5411 |
NN |
denotes |
evasion |
T811 |
5412-5419 |
NN |
denotes |
ability |
T812 |
5421-5429 |
RB |
denotes |
Together |
T813 |
5429-5430 |
-COMMA- |
denotes |
, |
T814 |
5431-5436 |
DT |
denotes |
these |
T815 |
5437-5441 |
NNS |
denotes |
data |
T816 |
5442-5452 |
VBP |
denotes |
underscore |
T817 |
5453-5456 |
DT |
denotes |
the |
T818 |
5457-5467 |
NN |
denotes |
importance |
T819 |
5468-5470 |
IN |
denotes |
of |
T820 |
5471-5484 |
NN |
denotes |
glycosylation |
T821 |
5485-5487 |
IN |
denotes |
in |
T822 |
5488-5493 |
JJ |
denotes |
viral |
T823 |
5494-5500 |
JJ |
denotes |
immune |
T824 |
5501-5508 |
NN |
denotes |
evasion |
T825 |
5511-5518 |
NNS |
denotes |
Results |
T826 |
5519-5522 |
CC |
denotes |
and |
T827 |
5523-5533 |
NN |
denotes |
discussion |
T828 |
5535-5541 |
NN |
denotes |
Glycan |
T829 |
5542-5552 |
NN |
denotes |
processing |
T830 |
5553-5555 |
IN |
denotes |
of |
T831 |
5556-5564 |
JJ |
denotes |
trimeric |
T832 |
5565-5569 |
NNS |
denotes |
SARS |
T833 |
5570-5573 |
CC |
denotes |
and |
T834 |
5574-5578 |
NNS |
denotes |
MERS |
T835 |
5579-5584 |
NN |
denotes |
spike |
T836 |
5585-5593 |
NNS |
denotes |
proteins |
T837 |
5594-5596 |
TO |
denotes |
To |
T838 |
5597-5605 |
VB |
denotes |
generate |
T839 |
5606-5607 |
DT |
denotes |
a |
T840 |
5608-5615 |
JJ |
denotes |
soluble |
T841 |
5616-5621 |
NN |
denotes |
mimic |
T842 |
5622-5624 |
IN |
denotes |
of |
T843 |
5625-5628 |
DT |
denotes |
the |
T844 |
5629-5634 |
JJ |
denotes |
viral |
T845 |
5635-5636 |
NN |
denotes |
S |
T846 |
5637-5645 |
NNS |
denotes |
proteins |
T847 |
5645-5646 |
-COMMA- |
denotes |
, |
T848 |
5647-5649 |
PRP |
denotes |
we |
T849 |
5650-5654 |
VBD |
denotes |
used |
T850 |
5655-5658 |
DT |
denotes |
the |
T851 |
5659-5672 |
JJ |
denotes |
2P-stabilised |
T852 |
5673-5684 |
JJ |
denotes |
native-like |
T853 |
5685-5689 |
NNS |
denotes |
SARS |
T854 |
5690-5693 |
CC |
denotes |
and |
T855 |
5694-5698 |
NNS |
denotes |
MERS |
T856 |
5699-5700 |
NN |
denotes |
S |
T857 |
5701-5708 |
NN |
denotes |
protein |
T858 |
5709-5717 |
NNS |
denotes |
antigens |
T859 |
5717-5718 |
-COMMA- |
denotes |
, |
T860 |
5719-5722 |
DT |
denotes |
the |
T861 |
5723-5729 |
NN |
denotes |
design |
T862 |
5730-5733 |
CC |
denotes |
and |
T863 |
5734-5744 |
NNS |
denotes |
structures |
T864 |
5745-5747 |
IN |
denotes |
of |
T865 |
5748-5753 |
WDT |
denotes |
which |
T866 |
5754-5758 |
VBP |
denotes |
have |
T867 |
5759-5763 |
VBN |
denotes |
been |
T868 |
5764-5773 |
VBN |
denotes |
described |
T869 |
5774-5784 |
RB |
denotes |
previously |
T870 |
5785-5787 |
IN |
denotes |
by |
T871 |
5788-5796 |
NNP |
denotes |
Pallesen |
T872 |
5797-5799 |
NNP |
denotes |
et |
T873 |
5800-5805 |
NN |
denotes |
al.41 |
T874 |
5807-5811 |
NNS |
denotes |
SARS |
T875 |
5811-5812 |
-COMMA- |
denotes |
, |
T876 |
5813-5817 |
NNS |
denotes |
MERS |
T877 |
5818-5821 |
CC |
denotes |
and |
T878 |
5822-5826 |
NN |
denotes |
HKU1 |
T879 |
5827-5828 |
NN |
denotes |
S |
T880 |
5829-5834 |
NNS |
denotes |
genes |
T881 |
5835-5841 |
VBP |
denotes |
encode |
T882 |
5842-5846 |
JJ |
denotes |
many |
T883 |
5847-5855 |
JJ |
denotes |
N-linked |
T884 |
5856-5862 |
NN |
denotes |
glycan |
T885 |
5863-5870 |
NNS |
denotes |
sequons |
T886 |
5870-5871 |
-SEMICOLON- |
denotes |
; |
T887 |
5872-5874 |
CD |
denotes |
23 |
T888 |
5874-5875 |
-COMMA- |
denotes |
, |
T889 |
5876-5878 |
CD |
denotes |
23 |
T890 |
5879-5882 |
CC |
denotes |
and |
T891 |
5883-5885 |
CD |
denotes |
29 |
T892 |
5885-5886 |
-COMMA- |
denotes |
, |
T893 |
5887-5899 |
RB |
denotes |
respectively |
T894 |
5900-5901 |
-LRB- |
denotes |
( |
T895 |
5901-5908 |
NN |
denotes |
Fig. 1a |
T896 |
5908-5909 |
-RRB- |
denotes |
) |
T897 |
5911-5913 |
PRP |
denotes |
We |
T898 |
5914-5923 |
RB |
denotes |
initially |
T899 |
5924-5930 |
VBD |
denotes |
sought |
T900 |
5931-5933 |
TO |
denotes |
to |
T901 |
5934-5948 |
RB |
denotes |
quantitatively |
T902 |
5949-5955 |
VB |
denotes |
assess |
T903 |
5956-5959 |
DT |
denotes |
the |
T904 |
5960-5971 |
NN |
denotes |
composition |
T905 |
5972-5974 |
IN |
denotes |
of |
T906 |
5975-5978 |
DT |
denotes |
the |
T907 |
5979-5991 |
NN |
denotes |
carbohydrate |
T908 |
5992-6002 |
NNS |
denotes |
structures |
T909 |
6003-6012 |
VBD |
denotes |
displayed |
T910 |
6013-6015 |
IN |
denotes |
on |
T911 |
6016-6019 |
DT |
denotes |
the |
T912 |
6020-6021 |
NN |
denotes |
S |
T913 |
6022-6035 |
NNS |
denotes |
glycoproteins |
T914 |
6037-6045 |
VBN |
denotes |
N-linked |
T915 |
6046-6053 |
NNS |
denotes |
glycans |
T916 |
6054-6058 |
VBD |
denotes |
were |
T917 |
6059-6072 |
RB |
denotes |
enzymatically |
T918 |
6073-6081 |
VBN |
denotes |
released |
T919 |
6081-6082 |
-COMMA- |
denotes |
, |
T920 |
6083-6096 |
RB |
denotes |
fluorescently |
T921 |
6097-6105 |
VBN |
denotes |
labelled |
T922 |
6105-6106 |
-COMMA- |
denotes |
, |
T923 |
6107-6110 |
CC |
denotes |
and |
T924 |
6111-6120 |
VBN |
denotes |
subjected |
T925 |
6121-6123 |
TO |
denotes |
to |
T926 |
6124-6135 |
JJ |
denotes |
hydrophilic |
T927 |
6136-6147 |
NN |
denotes |
interaction |
T928 |
6148-6180 |
NN |
denotes |
chromatography-ultra-performance |
T929 |
6181-6187 |
NN |
denotes |
liquid |
T930 |
6188-6202 |
NN |
denotes |
chromatography |
T931 |
6203-6204 |
-LRB- |
denotes |
( |
T932 |
6204-6214 |
NN |
denotes |
HILIC-UPLC |
T933 |
6214-6215 |
-RRB- |
denotes |
) |
T934 |
6217-6226 |
NN |
denotes |
Treatment |
T935 |
6227-6231 |
IN |
denotes |
with |
T936 |
6232-6247 |
NN |
denotes |
endoglycosidase |
T937 |
6248-6249 |
NN |
denotes |
H |
T938 |
6250-6251 |
-LRB- |
denotes |
( |
T939 |
6251-6255 |
NNP |
denotes |
Endo |
T940 |
6256-6257 |
NN |
denotes |
H |
T941 |
6257-6258 |
-RRB- |
denotes |
) |
T942 |
6259-6267 |
VBD |
denotes |
revealed |
T943 |
6268-6269 |
DT |
denotes |
a |
T944 |
6270-6280 |
NN |
denotes |
population |
T945 |
6281-6282 |
-LRB- |
denotes |
( |
T946 |
6282-6286 |
NN |
denotes |
SARS |
T947 |
6287-6291 |
CD |
denotes |
32.2 |
T948 |
6291-6292 |
NN |
denotes |
% |
T949 |
6292-6293 |
-SEMICOLON- |
denotes |
; |
T950 |
6294-6298 |
NNS |
denotes |
MERS |
T951 |
6299-6303 |
CD |
denotes |
33.8 |
T952 |
6303-6304 |
NN |
denotes |
% |
T953 |
6304-6305 |
-COMMA- |
denotes |
, |
T954 |
6306-6310 |
NN |
denotes |
HKU1 |
T955 |
6311-6315 |
CD |
denotes |
25.0 |
T956 |
6315-6316 |
NN |
denotes |
% |
T957 |
6316-6317 |
-RRB- |
denotes |
) |
T958 |
6318-6320 |
IN |
denotes |
of |
T959 |
6321-6335 |
VBN |
denotes |
underprocessed |
T960 |
6336-6353 |
JJ |
denotes |
oligomannose-type |
T961 |
6354-6361 |
NNS |
denotes |
glycans |
T962 |
6362-6363 |
-LRB- |
denotes |
( |
T963 |
6363-6370 |
NN |
denotes |
Fig. 1b |
T964 |
6370-6371 |
-RRB- |
denotes |
) |
T965 |
6373-6377 |
DT |
denotes |
This |
T966 |
6378-6389 |
NN |
denotes |
observation |
T967 |
6390-6392 |
IN |
denotes |
of |
T968 |
6393-6397 |
CC |
denotes |
both |
T969 |
6398-6405 |
JJ |
denotes |
complex |
T970 |
6406-6409 |
CC |
denotes |
and |
T971 |
6410-6427 |
JJ |
denotes |
oligomannose-type |
T972 |
6428-6435 |
NNS |
denotes |
glycans |
T973 |
6436-6443 |
VBZ |
denotes |
reveals |
T974 |
6444-6448 |
IN |
denotes |
that |
T975 |
6449-6452 |
DT |
denotes |
the |
T976 |
6453-6461 |
NN |
denotes |
majority |
T977 |
6462-6464 |
IN |
denotes |
of |
T978 |
6465-6473 |
JJ |
denotes |
N-linked |
T979 |
6474-6481 |
NNS |
denotes |
glycans |
T980 |
6482-6485 |
MD |
denotes |
can |
T981 |
6486-6488 |
VB |
denotes |
be |
T982 |
6489-6498 |
VBN |
denotes |
processed |
T983 |
6498-6499 |
-COMMA- |
denotes |
, |
T984 |
6500-6508 |
IN |
denotes |
although |
T985 |
6509-6514 |
EX |
denotes |
there |
T986 |
6515-6517 |
VBZ |
denotes |
is |
T987 |
6518-6525 |
JJ |
denotes |
limited |
T988 |
6526-6536 |
NN |
denotes |
processing |
T989 |
6537-6539 |
IN |
denotes |
at |
T990 |
6540-6548 |
JJ |
denotes |
specific |
T991 |
6549-6554 |
NNS |
denotes |
sites |
T992 |
6555-6561 |
IN |
denotes |
across |
T993 |
6562-6565 |
DT |
denotes |
the |
T994 |
6566-6567 |
NN |
denotes |
S |
T995 |
6568-6576 |
NNS |
denotes |
proteins |
T996 |
6578-6580 |
PRP |
denotes |
It |
T997 |
6581-6583 |
VBZ |
denotes |
is |
T998 |
6584-6588 |
RB |
denotes |
also |
T999 |
6589-6600 |
JJ |
denotes |
interesting |
T1000 |
6601-6603 |
TO |
denotes |
to |
T1001 |
6604-6608 |
VB |
denotes |
note |
T1002 |
6609-6613 |
IN |
denotes |
that |
T1003 |
6614-6617 |
DT |
denotes |
the |
T1004 |
6618-6630 |
NN |
denotes |
distribution |
T1005 |
6631-6633 |
IN |
denotes |
of |
T1006 |
6634-6651 |
JJ |
denotes |
oligomannose-type |
T1007 |
6652-6659 |
NNS |
denotes |
glycans |
T1008 |
6660-6663 |
VBD |
denotes |
was |
T1009 |
6664-6669 |
JJ |
denotes |
broad |
T1010 |
6669-6670 |
-COMMA- |
denotes |
, |
T1011 |
6671-6675 |
IN |
denotes |
with |
T1012 |
6676-6687 |
NN |
denotes |
Man5GlcNAc2 |
T1013 |
6688-6690 |
TO |
denotes |
to |
T1014 |
6691-6702 |
NN |
denotes |
Man9GlcNAc2 |
T1015 |
6703-6710 |
NNS |
denotes |
glycans |
T1016 |
6711-6714 |
DT |
denotes |
all |
T1017 |
6715-6722 |
VBP |
denotes |
present |
T1018 |
6722-6723 |
-COMMA- |
denotes |
, |
T1019 |
6724-6731 |
IN |
denotes |
without |
T1020 |
6732-6735 |
CD |
denotes |
one |
T1021 |
6736-6746 |
JJ |
denotes |
particular |
T1022 |
6747-6755 |
JJ |
denotes |
dominant |
T1023 |
6756-6760 |
NN |
denotes |
peak |
T1024 |
6760-6761 |
-COMMA- |
denotes |
, |
T1025 |
6762-6764 |
IN |
denotes |
as |
T1026 |
6765-6767 |
VBZ |
denotes |
is |
T1027 |
6768-6771 |
DT |
denotes |
the |
T1028 |
6772-6776 |
NN |
denotes |
case |
T1029 |
6777-6780 |
IN |
denotes |
for |
T1030 |
6781-6785 |
DT |
denotes |
some |
T1031 |
6786-6791 |
JJ |
denotes |
viral |
T1032 |
6792-6805 |
NNS |
denotes |
glycoproteins |
T1033 |
6805-6806 |
-COMMA- |
denotes |
, |
T1034 |
6807-6811 |
JJ |
denotes |
such |
T1035 |
6812-6814 |
IN |
denotes |
as |
T1036 |
6815-6820 |
NN |
denotes |
HIV-1 |
T1037 |
6821-6826 |
NN |
denotes |
Env36 |
T1038 |
6828-6831 |
DT |
denotes |
The |
T1039 |
6832-6842 |
NN |
denotes |
proportion |
T1040 |
6843-6845 |
IN |
denotes |
of |
T1041 |
6846-6863 |
JJ |
denotes |
oligomannose-type |
T1042 |
6864-6871 |
NNS |
denotes |
glycans |
T1043 |
6872-6874 |
IN |
denotes |
on |
T1044 |
6875-6886 |
JJ |
denotes |
recombinant |
T1045 |
6887-6898 |
NN |
denotes |
coronavirus |
T1046 |
6899-6900 |
NN |
denotes |
S |
T1047 |
6901-6909 |
NNS |
denotes |
proteins |
T1048 |
6910-6912 |
VBZ |
denotes |
is |
T1049 |
6913-6923 |
JJ |
denotes |
consistent |
T1050 |
6924-6928 |
IN |
denotes |
with |
T1051 |
6929-6937 |
JJ |
denotes |
previous |
T1052 |
6938-6945 |
NNS |
denotes |
studies |
T1053 |
6946-6955 |
VBN |
denotes |
performed |
T1054 |
6956-6958 |
IN |
denotes |
on |
T1055 |
6959-6966 |
RB |
denotes |
virally |
T1056 |
6967-6974 |
VBN |
denotes |
derived |
T1057 |
6975-6979 |
NNS |
denotes |
MERS |
T1058 |
6980-6983 |
CC |
denotes |
and |
T1059 |
6984-6988 |
NN |
denotes |
SARS |
T1060 |
6989-7000 |
NN |
denotes |
coronavirus |
T1061 |
7001-7002 |
NN |
denotes |
S |
T1062 |
7003-7016 |
NN |
denotes |
proteins17,42 |
T1063 |
7018-7031 |
NNS |
denotes |
Coronaviruses |
T1064 |
7032-7036 |
VBP |
denotes |
have |
T1065 |
7037-7041 |
VBN |
denotes |
been |
T1066 |
7042-7052 |
RB |
denotes |
previously |
T1067 |
7053-7057 |
VBN |
denotes |
been |
T1068 |
7058-7066 |
VBN |
denotes |
reported |
T1069 |
7067-7069 |
TO |
denotes |
to |
T1070 |
7070-7074 |
VB |
denotes |
form |
T1071 |
7075-7082 |
NNS |
denotes |
virions |
T1072 |
7083-7085 |
IN |
denotes |
by |
T1073 |
7086-7093 |
VBG |
denotes |
budding |
T1074 |
7094-7098 |
IN |
denotes |
into |
T1075 |
7099-7102 |
DT |
denotes |
the |
T1076 |
7103-7108 |
NN |
denotes |
lumen |
T1077 |
7109-7111 |
IN |
denotes |
of |
T1078 |
7112-7123 |
JJ |
denotes |
endoplasmic |
T1079 |
7124-7139 |
JJ |
denotes |
reticulum-Golgi |
T1080 |
7140-7152 |
JJ |
denotes |
intermediate |
T1081 |
7153-7165 |
NNS |
denotes |
compartments |
T1082 |
7166-7167 |
-LRB- |
denotes |
( |
T1083 |
7167-7172 |
NN |
denotes |
ERGIC |
T1084 |
7172-7173 |
-RRB- |
denotes |
) |
T1085 |
7173-7178 |
CD |
denotes |
43,44 |
T1086 |
7180-7192 |
NNS |
denotes |
Observations |
T1087 |
7193-7195 |
IN |
denotes |
of |
T1088 |
7196-7203 |
NN |
denotes |
hybrid- |
T1089 |
7204-7207 |
CC |
denotes |
and |
T1090 |
7208-7220 |
JJ |
denotes |
complex-type |
T1091 |
7221-7228 |
NNS |
denotes |
glycans |
T1092 |
7229-7231 |
IN |
denotes |
on |
T1093 |
7232-7239 |
RB |
denotes |
virally |
T1094 |
7240-7247 |
VBN |
denotes |
derived |
T1095 |
7248-7261 |
NN |
denotes |
material17,42 |
T1096 |
7262-7267 |
MD |
denotes |
would |
T1097 |
7267-7268 |
-COMMA- |
denotes |
, |
T1098 |
7269-7276 |
RB |
denotes |
however |
T1099 |
7276-7277 |
-COMMA- |
denotes |
, |
T1100 |
7278-7285 |
VBP |
denotes |
suggest |
T1101 |
7286-7290 |
IN |
denotes |
that |
T1102 |
7291-7293 |
PRP |
denotes |
it |
T1103 |
7294-7296 |
VBZ |
denotes |
is |
T1104 |
7297-7303 |
JJ |
denotes |
likely |
T1105 |
7304-7308 |
IN |
denotes |
that |
T1106 |
7309-7320 |
NN |
denotes |
coronavirus |
T1107 |
7321-7328 |
NNS |
denotes |
virions |
T1108 |
7329-7335 |
VBP |
denotes |
travel |
T1109 |
7336-7343 |
IN |
denotes |
through |
T1110 |
7344-7347 |
DT |
denotes |
the |
T1111 |
7348-7353 |
NNP |
denotes |
Golgi |
T1112 |
7354-7363 |
NN |
denotes |
apparatus |
T1113 |
7364-7369 |
IN |
denotes |
after |
T1114 |
7370-7376 |
NN |
denotes |
virion |
T1115 |
7377-7386 |
NN |
denotes |
formation |
T1116 |
7387-7389 |
IN |
denotes |
in |
T1117 |
7390-7393 |
DT |
denotes |
the |
T1118 |
7394-7399 |
NN |
denotes |
ERGIC |
T1119 |
7400-7402 |
IN |
denotes |
en |
T1120 |
7403-7408 |
NN |
denotes |
route |
T1121 |
7409-7411 |
TO |
denotes |
to |
T1122 |
7412-7415 |
DT |
denotes |
the |
T1123 |
7416-7420 |
NN |
denotes |
cell |
T1124 |
7421-7428 |
NN |
denotes |
surface |
T1125 |
7428-7429 |
-COMMA- |
denotes |
, |
T1126 |
7430-7434 |
RB |
denotes |
thus |
T1127 |
7435-7445 |
VBG |
denotes |
supporting |
T1128 |
7446-7457 |
JJ |
denotes |
recombinant |
T1129 |
7458-7468 |
NNS |
denotes |
immunogens |
T1130 |
7469-7471 |
IN |
denotes |
as |
T1131 |
7472-7478 |
NNS |
denotes |
models |
T1132 |
7479-7481 |
IN |
denotes |
of |
T1133 |
7482-7487 |
JJ |
denotes |
viral |
T1134 |
7488-7501 |
NNS |
denotes |
glycoproteins |
T1135 |
7503-7507 |
NNP |
denotes |
Fig. |
T1136 |
7508-7509 |
CD |
denotes |
1 |
T1137 |
7510-7523 |
JJ |
denotes |
Compositional |
T1138 |
7524-7532 |
NN |
denotes |
analysis |
T1139 |
7533-7535 |
IN |
denotes |
of |
T1140 |
7536-7540 |
NNP |
denotes |
SARS |
T1141 |
7540-7541 |
-COMMA- |
denotes |
, |
T1142 |
7542-7546 |
NNS |
denotes |
MERS |
T1143 |
7547-7550 |
CC |
denotes |
and |
T1144 |
7551-7555 |
NN |
denotes |
HKU1 |
T1145 |
7556-7563 |
NNS |
denotes |
glycans |
T1146 |
7565-7566 |
DT |
denotes |
a |
T1147 |
7567-7576 |
JJ |
denotes |
Schematic |
T1148 |
7577-7591 |
NN |
denotes |
representation |
T1149 |
7592-7594 |
IN |
denotes |
of |
T1150 |
7595-7599 |
NNP |
denotes |
SARS |
T1151 |
7599-7600 |
-COMMA- |
denotes |
, |
T1152 |
7601-7605 |
NNS |
denotes |
MERS |
T1153 |
7606-7609 |
CC |
denotes |
and |
T1154 |
7610-7614 |
NN |
denotes |
HKU1 |
T1155 |
7615-7626 |
NN |
denotes |
coronavirus |
T1156 |
7627-7628 |
NN |
denotes |
S |
T1157 |
7629-7642 |
NNS |
denotes |
glycoproteins |
T1158 |
7642-7643 |
-COMMA- |
denotes |
, |
T1159 |
7644-7651 |
VBG |
denotes |
showing |
T1160 |
7652-7655 |
DT |
denotes |
the |
T1161 |
7656-7665 |
NNS |
denotes |
positions |
T1162 |
7666-7668 |
IN |
denotes |
of |
T1163 |
7669-7677 |
JJ |
denotes |
N-linked |
T1164 |
7678-7691 |
NN |
denotes |
glycosylation |
T1165 |
7692-7702 |
JJ |
denotes |
amino-acid |
T1166 |
7703-7710 |
NNS |
denotes |
sequons |
T1167 |
7711-7712 |
-LRB- |
denotes |
( |
T1168 |
7712-7717 |
NN |
denotes |
NXS/T |
T1169 |
7717-7718 |
-COMMA- |
denotes |
, |
T1170 |
7719-7724 |
WRB |
denotes |
where |
T1171 |
7725-7730 |
NN |
denotes |
X ≠ P |
T1172 |
7730-7731 |
-RRB- |
denotes |
) |
T1173 |
7732-7737 |
VBN |
denotes |
shown |
T1174 |
7738-7740 |
IN |
denotes |
as |
T1175 |
7741-7749 |
NNS |
denotes |
branches |
T1177 |
8291-8308 |
JJ |
denotes |
Oligomannose-type |
T1178 |
8309-8316 |
NNS |
denotes |
glycans |
T1179 |
8317-8320 |
VBP |
denotes |
are |
T1180 |
8321-8334 |
RB |
denotes |
schematically |
T1181 |
8335-8344 |
VBN |
denotes |
annotated |
T1182 |
8345-8349 |
IN |
denotes |
with |
T1183 |
8350-8357 |
NN |
denotes |
mannose |
T1184 |
8358-8366 |
NNS |
denotes |
residues |
T1185 |
8367-8369 |
IN |
denotes |
as |
T1186 |
8370-8375 |
JJ |
denotes |
green |
T1187 |
8376-8383 |
NNS |
denotes |
circles |
T1188 |
8384-8387 |
CC |
denotes |
and |
T1189 |
8388-8394 |
NN |
denotes |
GlcNAc |
T1190 |
8395-8403 |
NNS |
denotes |
residues |
T1191 |
8404-8406 |
IN |
denotes |
as |
T1192 |
8407-8411 |
JJ |
denotes |
blue |
T1193 |
8412-8419 |
NNS |
denotes |
squares |
T1194 |
8421-8423 |
TO |
denotes |
To |
T1195 |
8424-8433 |
VB |
denotes |
ascertain |
T1196 |
8434-8437 |
DT |
denotes |
the |
T1197 |
8438-8445 |
JJ |
denotes |
precise |
T1198 |
8446-8456 |
NNS |
denotes |
structures |
T1199 |
8457-8459 |
IN |
denotes |
of |
T1200 |
8460-8468 |
JJ |
denotes |
N-linked |
T1201 |
8469-8476 |
NNS |
denotes |
glycans |
T1202 |
8476-8477 |
-COMMA- |
denotes |
, |
T1203 |
8478-8484 |
NN |
denotes |
glycan |
T1204 |
8485-8490 |
NNS |
denotes |
pools |
T1205 |
8491-8493 |
IN |
denotes |
of |
T1206 |
8494-8498 |
DT |
denotes |
each |
T1207 |
8499-8510 |
NN |
denotes |
coronavirus |
T1208 |
8511-8512 |
NN |
denotes |
S |
T1209 |
8513-8520 |
NN |
denotes |
protein |
T1210 |
8521-8525 |
VBD |
denotes |
were |
T1211 |
8526-8534 |
VBN |
denotes |
analysed |
T1212 |
8535-8537 |
IN |
denotes |
by |
T1213 |
8538-8550 |
JJ |
denotes |
negative-ion |
T1214 |
8551-8576 |
NN |
denotes |
ion-mobility-electrospray |
T1215 |
8577-8587 |
NN |
denotes |
ionisation |
T1216 |
8588-8592 |
NN |
denotes |
mass |
T1217 |
8593-8605 |
NN |
denotes |
spectrometry |
T1218 |
8606-8607 |
-LRB- |
denotes |
( |
T1219 |
8607-8613 |
NN |
denotes |
IM-ESI |
T1220 |
8614-8616 |
NN |
denotes |
MS |
T1221 |
8616-8617 |
-RRB- |
denotes |
) |
T1222 |
8618-8619 |
-LRB- |
denotes |
( |
T1223 |
8619-8632 |
JJ |
denotes |
Supplementary |
T1224 |
8633-8639 |
NN |
denotes |
Fig. 1 |
T1225 |
8639-8640 |
-RRB- |
denotes |
) |
T1226 |
8642-8652 |
JJ |
denotes |
Consistent |
T1227 |
8653-8657 |
IN |
denotes |
with |
T1228 |
8658-8661 |
DT |
denotes |
the |
T1229 |
8662-8666 |
NN |
denotes |
UPLC |
T1230 |
8667-8671 |
NNS |
denotes |
data |
T1231 |
8671-8672 |
-COMMA- |
denotes |
, |
T1232 |
8673-8679 |
NNP |
denotes |
IM-ESI |
T1233 |
8680-8682 |
NNP |
denotes |
MS |
T1234 |
8683-8692 |
VBD |
denotes |
confirmed |
T1235 |
8693-8695 |
DT |
denotes |
an |
T1236 |
8696-8701 |
NN |
denotes |
array |
T1237 |
8702-8704 |
IN |
denotes |
of |
T1238 |
8705-8717 |
JJ |
denotes |
complex-type |
T1239 |
8718-8725 |
NNS |
denotes |
glycans |
T1240 |
8726-8733 |
VBG |
denotes |
ranging |
T1241 |
8734-8738 |
IN |
denotes |
from |
T1242 |
8739-8744 |
NN |
denotes |
mono- |
T1243 |
8745-8747 |
TO |
denotes |
to |
T1244 |
8748-8763 |
JJ |
denotes |
tetra-antennary |
T1245 |
8763-8764 |
-COMMA- |
denotes |
, |
T1246 |
8765-8768 |
CC |
denotes |
but |
T1247 |
8769-8773 |
RB |
denotes |
also |
T1248 |
8774-8787 |
NN |
denotes |
oligomannose- |
T1249 |
8788-8791 |
CC |
denotes |
and |
T1250 |
8792-8803 |
JJ |
denotes |
hybrid-type |
T1251 |
8804-8811 |
NNS |
denotes |
glycans |
T1252 |
8813-8816 |
DT |
denotes |
The |
T1253 |
8817-8823 |
NN |
denotes |
glycan |
T1254 |
8824-8836 |
NNS |
denotes |
compositions |
T1255 |
8837-8850 |
VBN |
denotes |
characterised |
T1256 |
8851-8853 |
IN |
denotes |
in |
T1257 |
8854-8857 |
DT |
denotes |
the |
T1258 |
8858-8865 |
NNS |
denotes |
spectra |
T1259 |
8866-8870 |
VBD |
denotes |
were |
T1260 |
8871-8878 |
RB |
denotes |
largely |
T1261 |
8879-8888 |
JJ |
denotes |
invariant |
T1262 |
8889-8894 |
IN |
denotes |
among |
T1263 |
8895-8898 |
DT |
denotes |
the |
T1264 |
8899-8912 |
NNS |
denotes |
coronaviruses |
T1265 |
8913-8917 |
IN |
denotes |
with |
T1266 |
8918-8920 |
DT |
denotes |
no |
T1267 |
8921-8926 |
JJ |
denotes |
major |
T1268 |
8927-8937 |
JJ |
denotes |
structural |
T1269 |
8938-8949 |
NNS |
denotes |
differences |
T1270 |
8950-8958 |
VBN |
denotes |
observed |
T1271 |
8961-8971 |
NN |
denotes |
Clustering |
T1272 |
8972-8974 |
IN |
denotes |
of |
T1273 |
8975-8989 |
JJ |
denotes |
underprocessed |
T1274 |
8990-8997 |
NNS |
denotes |
glycans |
T1275 |
8998-9000 |
IN |
denotes |
on |
T1276 |
9001-9005 |
NNS |
denotes |
MERS |
T1277 |
9006-9007 |
NN |
denotes |
S |
T68424 |
9008-9010 |
PRP |
denotes |
We |
T7134 |
9011-9023 |
RB |
denotes |
subsequently |
T76564 |
9024-9033 |
VBD |
denotes |
performed |
T84609 |
9034-9046 |
NN |
denotes |
glycopeptide |
T22031 |
9047-9055 |
NN |
denotes |
analysis |
T45093 |
9056-9058 |
TO |
denotes |
to |
T79801 |
9059-9068 |
VB |
denotes |
ascertain |
T52563 |
9069-9072 |
DT |
denotes |
the |
T41193 |
9073-9085 |
NNS |
denotes |
compositions |
T88928 |
9086-9088 |
IN |
denotes |
of |
T13523 |
9089-9096 |
NNS |
denotes |
glycans |
T54555 |
9097-9099 |
IN |
denotes |
at |
T13277 |
9100-9103 |
DT |
denotes |
all |
T38634 |
9104-9106 |
IN |
denotes |
of |
T33467 |
9107-9110 |
DT |
denotes |
the |
T42060 |
9111-9120 |
JJ |
denotes |
potential |
T99523 |
9121-9129 |
JJ |
denotes |
N-linked |
T99446 |
9130-9143 |
NN |
denotes |
glycosylation |
T21366 |
9144-9149 |
NNS |
denotes |
sites |
T22927 |
9150-9151 |
-LRB- |
denotes |
( |
T74512 |
9151-9155 |
NNS |
denotes |
PNGs |
T79360 |
9155-9156 |
-RRB- |
denotes |
) |
T78780 |
9158-9162 |
NNS |
denotes |
MERS |
T54967 |
9162-9163 |
-COMMA- |
denotes |
, |
T43119 |
9164-9168 |
NN |
denotes |
SARS |
T79243 |
9169-9172 |
CC |
denotes |
and |
T12013 |
9173-9177 |
NN |
denotes |
HKU1 |
T9774 |
9178-9189 |
JJ |
denotes |
recombinant |
T20303 |
9190-9191 |
NN |
denotes |
S |
T31427 |
9192-9200 |
NNS |
denotes |
proteins |
T76296 |
9201-9205 |
VBD |
denotes |
were |
T47095 |
9206-9213 |
VBN |
denotes |
reduced |
T76573 |
9213-9214 |
-COMMA- |
denotes |
, |
T86504 |
9215-9224 |
VBN |
denotes |
alkylated |
T10460 |
9225-9228 |
CC |
denotes |
and |
T8652 |
9229-9237 |
VBN |
denotes |
digested |
T27352 |
9238-9242 |
IN |
denotes |
with |
T80310 |
9243-9245 |
DT |
denotes |
an |
T76651 |
9246-9256 |
NN |
denotes |
assortment |
T63553 |
9257-9259 |
IN |
denotes |
of |
T52033 |
9260-9269 |
NNS |
denotes |
proteases |
T24947 |
9270-9272 |
TO |
denotes |
to |
T50688 |
9273-9278 |
VB |
denotes |
yield |
T80082 |
9279-9292 |
NNS |
denotes |
glycopeptides |
T99831 |
9292-9293 |
-COMMA- |
denotes |
, |
T33781 |
9294-9299 |
WDT |
denotes |
which |
T20638 |
9300-9304 |
VBD |
denotes |
were |
T35120 |
9305-9314 |
VBN |
denotes |
subjected |
T25962 |
9315-9317 |
TO |
denotes |
to |
T78058 |
9318-9325 |
JJ |
denotes |
in-line |
T75900 |
9326-9332 |
JJ |
denotes |
liquid |
T31589 |
9333-9352 |
NN |
denotes |
chromatography-mass |
T18666 |
9353-9365 |
NN |
denotes |
spectrometry |
T45711 |
9366-9367 |
-LRB- |
denotes |
( |
T15066 |
9367-9372 |
NN |
denotes |
LC-MS |
T82375 |
9372-9373 |
-RRB- |
denotes |
) |
T18459 |
9375-9379 |
DT |
denotes |
This |
T55071 |
9380-9388 |
VBD |
denotes |
revealed |
T51085 |
9389-9401 |
JJ |
denotes |
differential |
T88367 |
9402-9408 |
NNS |
denotes |
levels |
T70083 |
9409-9411 |
IN |
denotes |
of |
T79246 |
9412-9424 |
NN |
denotes |
oligomannose |
T85438 |
9424-9425 |
-COMMA- |
denotes |
, |
T39117 |
9426-9432 |
NN |
denotes |
hybrid |
T22989 |
9432-9433 |
-COMMA- |
denotes |
, |
T20968 |
9434-9437 |
CC |
denotes |
and |
T49737 |
9438-9450 |
JJ |
denotes |
complex-type |
T78484 |
9451-9457 |
NN |
denotes |
glycan |
T72051 |
9458-9469 |
NNS |
denotes |
populations |
T75452 |
9470-9471 |
-LRB- |
denotes |
( |
T62826 |
9471-9478 |
NN |
denotes |
Fig. 2a |
T41174 |
9478-9479 |
-COMMA- |
denotes |
, |
T16399 |
9480-9481 |
NN |
denotes |
b |
T14860 |
9481-9482 |
-RRB- |
denotes |
) |
T56558 |
9484-9489 |
VBG |
denotes |
Using |
T28749 |
9490-9500 |
NNS |
denotes |
structures |
T33039 |
9501-9503 |
IN |
denotes |
of |
T74888 |
9504-9507 |
DT |
denotes |
the |
T85424 |
9508-9516 |
JJ |
denotes |
trimeric |
T52754 |
9517-9521 |
NNS |
denotes |
MERS |
T31179 |
9522-9525 |
CC |
denotes |
and |
T61603 |
9526-9530 |
NNP |
denotes |
SARS |
T11525 |
9531-9532 |
NN |
denotes |
S |
T81925 |
9533-9541 |
NNS |
denotes |
proteins |
T15094 |
9542-9543 |
-LRB- |
denotes |
( |
T17734 |
9543-9546 |
NN |
denotes |
PDB |
T49127 |
9547-9549 |
NN |
denotes |
ID |
T41188 |
9549-9550 |
-COLON- |
denotes |
: |
T82842 |
9551-9555 |
NN |
denotes |
5X59 |
T94035 |
9556-9559 |
CC |
denotes |
and |
T4129 |
9560-9564 |
NN |
denotes |
5X58 |
T93804 |
9564-9565 |
-COMMA- |
denotes |
, |
T25861 |
9566-9578 |
RB |
denotes |
respectively |
T44190 |
9578-9579 |
-RRB- |
denotes |
) |
T83072 |
9579-9580 |
-COMMA- |
denotes |
, |
T56951 |
9581-9583 |
PRP |
denotes |
we |
T84875 |
9584-9593 |
VBD |
denotes |
generated |
T16354 |
9594-9600 |
NNS |
denotes |
models |
T90159 |
9601-9603 |
IN |
denotes |
of |
T64487 |
9604-9609 |
RB |
denotes |
fully |
T51670 |
9610-9622 |
VBN |
denotes |
glycosylated |
T11954 |
9623-9634 |
NN |
denotes |
coronavirus |
T96423 |
9635-9641 |
NNS |
denotes |
spikes |
T16192 |
9642-9647 |
VBG |
denotes |
using |
T41991 |
9648-9662 |
RB |
denotes |
experimentally |
T34640 |
9663-9673 |
VBN |
denotes |
determined |
T73736 |
9674-9680 |
NN |
denotes |
glycan |
T93669 |
9681-9693 |
NNS |
denotes |
compositions |
T17443 |
9694-9695 |
-LRB- |
denotes |
( |
T79807 |
9695-9702 |
NN |
denotes |
Fig. 3a |
T84889 |
9702-9703 |
-COMMA- |
denotes |
, |
T56236 |
9704-9705 |
NN |
denotes |
b |
T87991 |
9705-9706 |
-RRB- |
denotes |
) |
T91445 |
9708-9712 |
DT |
denotes |
This |
T32785 |
9713-9721 |
VBD |
denotes |
revealed |
T90326 |
9722-9726 |
IN |
denotes |
that |
T49774 |
9727-9744 |
JJ |
denotes |
oligomannose-type |
T77922 |
9745-9752 |
NNS |
denotes |
glycans |
T26521 |
9753-9755 |
IN |
denotes |
on |
T6952 |
9756-9760 |
NNS |
denotes |
MERS |
T82084 |
9761-9762 |
NN |
denotes |
S |
T36749 |
9763-9774 |
VBP |
denotes |
co-localize |
T66900 |
9775-9777 |
TO |
denotes |
to |
T31749 |
9778-9786 |
JJ |
denotes |
specific |
T40780 |
9787-9795 |
NNS |
denotes |
clusters |
T42499 |
9796-9798 |
IN |
denotes |
on |
T28913 |
9799-9802 |
DT |
denotes |
the |
T99242 |
9803-9807 |
NN |
denotes |
head |
T67844 |
9808-9810 |
IN |
denotes |
of |
T51016 |
9811-9814 |
DT |
denotes |
the |
T78718 |
9815-9816 |
NN |
denotes |
S |
T82870 |
9817-9824 |
NN |
denotes |
protein |
T5951 |
9824-9825 |
-COMMA- |
denotes |
, |
T72350 |
9826-9836 |
VBG |
denotes |
consisting |
T71605 |
9837-9839 |
IN |
denotes |
of |
T54609 |
9840-9847 |
NNS |
denotes |
glycans |
T31759 |
9848-9850 |
IN |
denotes |
at |
T18955 |
9851-9857 |
NN |
denotes |
Asn155 |
T13208 |
9857-9858 |
-COMMA- |
denotes |
, |
T79227 |
9859-9865 |
NN |
denotes |
Asn166 |
T49578 |
9865-9866 |
-COMMA- |
denotes |
, |
T66915 |
9867-9870 |
CC |
denotes |
and |
T34772 |
9871-9877 |
NN |
denotes |
Asn236 |
T34488 |
9878-9879 |
-LRB- |
denotes |
( |
T13786 |
9879-9886 |
NN |
denotes |
Fig. 3a |
T99953 |
9886-9887 |
-RRB- |
denotes |
) |
T88607 |
9889-9891 |
PRP |
denotes |
We |
T60015 |
9892-9904 |
VBD |
denotes |
hypothesized |
T95784 |
9905-9909 |
IN |
denotes |
that |
T39313 |
9910-9913 |
DT |
denotes |
the |
T91856 |
9914-9919 |
RB |
denotes |
fully |
T9118 |
9920-9937 |
JJ |
denotes |
oligomannose-type |
T9345 |
9938-9944 |
NN |
denotes |
glycan |
T56514 |
9945-9955 |
NN |
denotes |
population |
T52338 |
9956-9958 |
IN |
denotes |
in |
T2332 |
9959-9963 |
DT |
denotes |
this |
T67337 |
9964-9971 |
NN |
denotes |
cluster |
T32151 |
9972-9978 |
VBZ |
denotes |
arises |
T48770 |
9979-9982 |
JJ |
denotes |
due |
T86749 |
9983-9985 |
TO |
denotes |
to |
T19511 |
9986-9989 |
DT |
denotes |
the |
T6499 |
9990-9998 |
VBN |
denotes |
hindered |
T30499 |
9999-10012 |
NN |
denotes |
accessibility |
T56293 |
10013-10015 |
IN |
denotes |
of |
T22648 |
10016-10022 |
NN |
denotes |
glycan |
T94530 |
10023-10033 |
NN |
denotes |
processing |
T53545 |
10034-10041 |
NNS |
denotes |
enzymes |
T29305 |
10042-10044 |
TO |
denotes |
to |
T79028 |
10045-10051 |
VB |
denotes |
access |
T66117 |
10052-10055 |
DT |
denotes |
the |
T4310 |
10056-10065 |
NN |
denotes |
substrate |
T8069 |
10066-10074 |
NN |
denotes |
glycan28 |
T69590 |
10076-10078 |
IN |
denotes |
As |
T28555 |
10079-10083 |
JJ |
denotes |
such |
T51816 |
10083-10084 |
-COMMA- |
denotes |
, |
T46678 |
10085-10087 |
PRP |
denotes |
we |
T91843 |
10088-10097 |
VBD |
denotes |
performed |
T80993 |
10098-10109 |
NN |
denotes |
mutagenesis |
T47375 |
10110-10112 |
TO |
denotes |
to |
T68681 |
10113-10118 |
VB |
denotes |
knock |
T20175 |
10119-10122 |
RP |
denotes |
out |
T89961 |
10123-10136 |
NN |
denotes |
glycosylation |
T13006 |
10137-10142 |
NNS |
denotes |
sites |
T17100 |
10143-10147 |
IN |
denotes |
with |
T12886 |
10148-10153 |
NN |
denotes |
N155A |
T64492 |
10153-10154 |
-COMMA- |
denotes |
, |
T78169 |
10155-10160 |
NN |
denotes |
N166A |
T20053 |
10160-10161 |
-COMMA- |
denotes |
, |
T50640 |
10162-10165 |
CC |
denotes |
and |
T12106 |
10166-10171 |
NN |
denotes |
N236A |
T5495 |
10172-10181 |
NNS |
denotes |
mutations |
T38605 |
10183-10196 |
JJ |
denotes |
Site-specific |
T73292 |
10197-10205 |
NN |
denotes |
analysis |
T67434 |
10206-10208 |
IN |
denotes |
of |
T70835 |
10209-10214 |
DT |
denotes |
these |
T43617 |
10215-10224 |
NN |
denotes |
glycan-KO |
T88004 |
10225-10232 |
NNS |
denotes |
mutants |
T25939 |
10233-10241 |
VBD |
denotes |
revealed |
T13557 |
10242-10250 |
VBN |
denotes |
enhanced |
T1670 |
10251-10259 |
NN |
denotes |
trimming |
T57479 |
10260-10262 |
IN |
denotes |
of |
T68502 |
10263-10270 |
NN |
denotes |
mannose |
T91138 |
10271-10279 |
NNS |
denotes |
residues |
T34347 |
10279-10280 |
-COMMA- |
denotes |
, |
T48546 |
10281-10285 |
FW |
denotes |
i.e. |
T76136 |
10286-10295 |
VBN |
denotes |
increased |
T14034 |
10296-10306 |
NN |
denotes |
processing |
T78905 |
10306-10307 |
-COMMA- |
denotes |
, |
T88293 |
10308-10312 |
WRB |
denotes |
when |
T83202 |
10313-10319 |
NN |
denotes |
glycan |
T70460 |
10320-10330 |
NN |
denotes |
clustering |
T30751 |
10331-10334 |
VBD |
denotes |
was |
T12473 |
10335-10342 |
VBN |
denotes |
reduced |
T49752 |
10343-10344 |
-LRB- |
denotes |
( |
T67538 |
10344-10346 |
NN |
denotes |
SI |
T99013 |
10347-10353 |
NN |
denotes |
Fig. 4 |
T79420 |
10353-10354 |
-RRB- |
denotes |
) |
T67059 |
10356-10359 |
DT |
denotes |
The |
T14141 |
10360-10368 |
NN |
denotes |
presence |
T95025 |
10369-10371 |
IN |
denotes |
of |
T69698 |
10372-10381 |
VBN |
denotes |
clustered |
T70586 |
10382-10399 |
JJ |
denotes |
oligomannose-type |
T74519 |
10400-10407 |
NNS |
denotes |
glycans |
T38719 |
10408-10410 |
VBZ |
denotes |
is |
T19161 |
10411-10422 |
JJ |
denotes |
reminiscent |
T96776 |
10423-10425 |
IN |
denotes |
of |
T24985 |
10426-10430 |
DT |
denotes |
that |
T40354 |
10431-10436 |
VBN |
denotes |
found |
T8442 |
10437-10439 |
IN |
denotes |
on |
T27531 |
10440-10445 |
JJ |
denotes |
other |
T77670 |
10446-10451 |
JJ |
denotes |
viral |
T91715 |
10452-10465 |
NNS |
denotes |
glycoproteins |
T67031 |
10465-10466 |
-COMMA- |
denotes |
, |
T58888 |
10467-10476 |
VBG |
denotes |
including |
T43383 |
10477-10482 |
NN |
denotes |
HIV-1 |
T2450 |
10483-10486 |
NN |
denotes |
Env |
T74217 |
10487-10490 |
CC |
denotes |
and |
T84923 |
10491-10495 |
NN |
denotes |
LASV |
T96185 |
10496-10516 |
NN |
denotes |
GPC24,31,34,36,45,46 |
T18456 |
10518-10522 |
NN |
denotes |
Fig. |
T38026 |
10523-10524 |
CD |
denotes |
2 |
T11696 |
10525-10537 |
JJ |
denotes |
Quantitative |
T81709 |
10538-10551 |
JJ |
denotes |
site-specific |
T93400 |
10552-10560 |
JJ |
denotes |
N-linked |
T30000 |
10561-10567 |
NN |
denotes |
glycan |
T11057 |
10568-10576 |
NN |
denotes |
analysis |
T72208 |
10577-10579 |
IN |
denotes |
of |
T91997 |
10580-10584 |
NNS |
denotes |
SARS |
T44946 |
10585-10588 |
CC |
denotes |
and |
T46103 |
10589-10593 |
NN |
denotes |
MERS |
T75132 |
10594-10605 |
NN |
denotes |
coronavirus |
T95276 |
10606-10611 |
NN |
denotes |
spike |
T3262 |
10612-10625 |
NNS |
denotes |
glycoproteins |
T84029 |
10627-10635 |
VBN |
denotes |
Purified |
T48343 |
10636-10637 |
-LRB- |
denotes |
( |
T26533 |
10637-10638 |
DT |
denotes |
a |
T86435 |
10638-10639 |
-RRB- |
denotes |
) |
T44348 |
10640-10644 |
NNS |
denotes |
MERS |
T9629 |
10645-10648 |
CC |
denotes |
and |
T48581 |
10649-10650 |
NN |
denotes |
b |
T35585 |
10651-10655 |
NNP |
denotes |
SARS |
T95868 |
10656-10657 |
NN |
denotes |
S |
T54061 |
10658-10666 |
NNS |
denotes |
proteins |
T60926 |
10667-10671 |
VBD |
denotes |
were |
T7737 |
10672-10694 |
JJ |
denotes |
digested. Quantitative |
T84409 |
10695-10708 |
JJ |
denotes |
site-specific |
T71906 |
10709-10717 |
JJ |
denotes |
N-linked |
T31843 |
10718-10724 |
NN |
denotes |
glycan |
T99530 |
10725-10733 |
NN |
denotes |
analysis |
T57258 |
10734-10736 |
IN |
denotes |
of |
T44594 |
10737-10738 |
DT |
denotes |
a |
T81945 |
10739-10743 |
NN |
denotes |
MERS |
T17293 |
10744-10747 |
CC |
denotes |
and |
T47096 |
10748-10749 |
NN |
denotes |
b |
T88210 |
10750-10754 |
NNP |
denotes |
SARS |
T89662 |
10755-10756 |
NNP |
denotes |
S |
T2440 |
10757-10770 |
NNS |
denotes |
glycoproteins |
T15012 |
10772-10780 |
VBN |
denotes |
Purified |
T24811 |
10781-10782 |
NN |
denotes |
S |
T17113 |
10783-10791 |
NNS |
denotes |
proteins |
T45227 |
10792-10796 |
VBD |
denotes |
were |
T93138 |
10797-10805 |
VBN |
denotes |
digested |
T86575 |
10806-10810 |
IN |
denotes |
with |
T51812 |
10811-10818 |
NN |
denotes |
trypsin |
T21664 |
10818-10819 |
-COMMA- |
denotes |
, |
T40461 |
10820-10832 |
NN |
denotes |
chymotrypsin |
T86817 |
10832-10833 |
-COMMA- |
denotes |
, |
T72210 |
10834-10845 |
JJ |
denotes |
alpha-lytic |
T56838 |
10846-10854 |
NN |
denotes |
protease |
T18984 |
10854-10855 |
-COMMA- |
denotes |
, |
T43478 |
10856-10861 |
NN |
denotes |
Glu-C |
T17765 |
10861-10862 |
-COMMA- |
denotes |
, |
T82693 |
10863-10866 |
CC |
denotes |
and |
T61553 |
10867-10874 |
NN |
denotes |
trypsin |
T17900 |
10875-10879 |
CC |
denotes |
plus |
T8143 |
10880-10892 |
NN |
denotes |
chymotrypsin |
T72819 |
10892-10893 |
-COMMA- |
denotes |
, |
T41703 |
10894-10898 |
RB |
denotes |
then |
T92120 |
10899-10907 |
VBN |
denotes |
analysed |
T90251 |
10908-10910 |
IN |
denotes |
by |
T16273 |
10911-10917 |
NN |
denotes |
LC-ESI |
T68396 |
10918-10920 |
NN |
denotes |
MS |
T44906 |
10922-10928 |
NN |
denotes |
Glycan |
T82137 |
10929-10941 |
NNS |
denotes |
compositions |
T30425 |
10942-10945 |
VBP |
denotes |
are |
T96908 |
10946-10951 |
VBN |
denotes |
based |
T54010 |
10952-10954 |
IN |
denotes |
on |
T48766 |
10955-10958 |
DT |
denotes |
the |
T91677 |
10959-10965 |
NN |
denotes |
glycan |
T73464 |
10966-10973 |
NN |
denotes |
library |
T90139 |
10974-10983 |
VBN |
denotes |
generated |
T52708 |
10984-10988 |
IN |
denotes |
from |
T79176 |
10989-11001 |
JJ |
denotes |
negative-ion |
T47018 |
11002-11006 |
NN |
denotes |
mass |
T10175 |
11007-11019 |
NN |
denotes |
spectrometry |
T31210 |
11020-11022 |
IN |
denotes |
of |
T92018 |
11023-11031 |
VBN |
denotes |
released |
T52131 |
11032-11041 |
NNS |
denotes |
N-glycans |
T86682 |
11043-11046 |
DT |
denotes |
The |
T44329 |
11047-11050 |
NN |
denotes |
bar |
T14374 |
11051-11057 |
NNS |
denotes |
graphs |
T64768 |
11058-11067 |
VBP |
denotes |
represent |
T3818 |
11068-11071 |
DT |
denotes |
the |
T94495 |
11072-11080 |
JJ |
denotes |
relative |
T48265 |
11081-11091 |
NNS |
denotes |
quantities |
T96495 |
11092-11094 |
IN |
denotes |
of |
T19945 |
11095-11099 |
DT |
denotes |
each |
T83205 |
11100-11106 |
NN |
denotes |
glycan |
T29095 |
11107-11112 |
NN |
denotes |
group |
T55384 |
11113-11117 |
IN |
denotes |
with |
T66610 |
11118-11135 |
JJ |
denotes |
oligomannose-type |
T19908 |
11136-11142 |
NN |
denotes |
glycan |
T86925 |
11143-11149 |
NN |
denotes |
series |
T92642 |
11150-11151 |
-LRB- |
denotes |
( |
T83803 |
11151-11153 |
NN |
denotes |
M9 |
T3618 |
11154-11156 |
TO |
denotes |
to |
T13438 |
11157-11159 |
NN |
denotes |
M5 |
T28189 |
11159-11160 |
-SEMICOLON- |
denotes |
; |
T91020 |
11161-11172 |
NN |
denotes |
Man9GlcNAc2 |
T50998 |
11173-11175 |
TO |
denotes |
to |
T81038 |
11176-11187 |
NN |
denotes |
Man5GlcNAc2 |
T43620 |
11187-11188 |
-RRB- |
denotes |
) |
T51798 |
11189-11190 |
-LRB- |
denotes |
( |
T99047 |
11190-11195 |
JJ |
denotes |
green |
T46694 |
11195-11196 |
-RRB- |
denotes |
) |
T68800 |
11196-11197 |
-COMMA- |
denotes |
, |
T39300 |
11198-11210 |
VBN |
denotes |
afucosylated |
T25055 |
11211-11214 |
CC |
denotes |
and |
T40035 |
11215-11226 |
VBN |
denotes |
fucosylated |
T28659 |
11227-11233 |
NN |
denotes |
hybrid |
T49864 |
11234-11241 |
NNS |
denotes |
glycans |
T85300 |
11242-11243 |
-LRB- |
denotes |
( |
T6763 |
11243-11249 |
NNP |
denotes |
Hybrid |
T31145 |
11250-11251 |
CC |
denotes |
& |
T19441 |
11252-11253 |
NNP |
denotes |
F |
T10907 |
11254-11260 |
NNP |
denotes |
Hybrid |
T44180 |
11260-11261 |
-RRB- |
denotes |
) |
T33083 |
11262-11263 |
-LRB- |
denotes |
( |
T64136 |
11263-11269 |
VBN |
denotes |
dashed |
T25133 |
11270-11274 |
NN |
denotes |
pink |
T8494 |
11274-11275 |
-RRB- |
denotes |
) |
T31666 |
11275-11276 |
-COMMA- |
denotes |
, |
T18761 |
11277-11280 |
CC |
denotes |
and |
T18896 |
11281-11288 |
JJ |
denotes |
complex |
T10070 |
11289-11296 |
NNS |
denotes |
glycans |
T81627 |
11297-11304 |
VBD |
denotes |
grouped |
T40473 |
11305-11314 |
VBG |
denotes |
according |
T20923 |
11315-11317 |
TO |
denotes |
to |
T55810 |
11318-11321 |
DT |
denotes |
the |
T71311 |
11322-11328 |
NN |
denotes |
number |
T36859 |
11329-11331 |
IN |
denotes |
of |
T43194 |
11332-11340 |
NNS |
denotes |
antennae |
T27706 |
11341-11344 |
CC |
denotes |
and |
T75366 |
11345-11353 |
NN |
denotes |
presence |
T12646 |
11354-11356 |
IN |
denotes |
of |
T91547 |
11357-11361 |
NN |
denotes |
core |
T95927 |
11362-11374 |
NN |
denotes |
fucosylation |
T75194 |
11375-11376 |
-LRB- |
denotes |
( |
T61150 |
11376-11378 |
NN |
denotes |
A1 |
T11703 |
11379-11381 |
TO |
denotes |
to |
T84163 |
11382-11385 |
NN |
denotes |
FA4 |
T52589 |
11385-11386 |
-RRB- |
denotes |
) |
T3633 |
11387-11388 |
-LRB- |
denotes |
( |
T70036 |
11388-11392 |
NN |
denotes |
pink |
T45573 |
11392-11393 |
-RRB- |
denotes |
) |
T26477 |
11395-11399 |
VBN |
denotes |
Left |
T2107 |
11400-11402 |
TO |
denotes |
to |
T54092 |
11403-11408 |
JJ |
denotes |
right |
T12300 |
11408-11409 |
-SEMICOLON- |
denotes |
; |
T51881 |
11410-11415 |
JJS |
denotes |
least |
T18623 |
11416-11425 |
VBN |
denotes |
processed |
T90503 |
11426-11428 |
TO |
denotes |
to |
T56324 |
11429-11433 |
RBS |
denotes |
most |
T7681 |
11434-11443 |
VBN |
denotes |
processed |
T36496 |
11445-11448 |
DT |
denotes |
The |
T76280 |
11449-11452 |
NN |
denotes |
pie |
T23755 |
11453-11459 |
NNS |
denotes |
charts |
T57945 |
11460-11469 |
VBP |
denotes |
summarise |
T4038 |
11470-11473 |
DT |
denotes |
the |
T33045 |
11474-11488 |
NN |
denotes |
quantification |
T90570 |
11489-11491 |
IN |
denotes |
of |
T98847 |
11492-11497 |
DT |
denotes |
these |
T1661 |
11498-11505 |
NNS |
denotes |
glycans |
T49504 |
11507-11517 |
JJ |
denotes |
Additional |
T14064 |
11518-11531 |
JJ |
denotes |
compositional |
T57392 |
11532-11543 |
NN |
denotes |
information |
T38584 |
11544-11553 |
VBG |
denotes |
regarding |
T17537 |
11554-11557 |
DT |
denotes |
the |
T42677 |
11558-11570 |
NN |
denotes |
distribution |
T43754 |
11571-11573 |
IN |
denotes |
of |
T2132 |
11574-11586 |
NN |
denotes |
fucosylation |
T30799 |
11587-11590 |
CC |
denotes |
and |
T46773 |
11591-11602 |
NN |
denotes |
sialylation |
T29532 |
11603-11606 |
MD |
denotes |
can |
T93684 |
11607-11609 |
VB |
denotes |
be |
T40276 |
11610-11615 |
VBN |
denotes |
found |
T86408 |
11616-11618 |
IN |
denotes |
in |
T98608 |
11619-11621 |
NN |
denotes |
SI |
T42803 |
11622-11628 |
NN |
denotes |
Fig. 3 |
T66723 |
11630-11634 |
CD |
denotes |
Fig. |
T49217 |
11635-11636 |
CD |
denotes |
3 |
T58946 |
11637-11652 |
JJ |
denotes |
Structure-based |
T75718 |
11653-11660 |
NN |
denotes |
mapping |
T97068 |
11661-11663 |
IN |
denotes |
of |
T12761 |
11664-11672 |
JJ |
denotes |
N-linked |
T25276 |
11673-11680 |
NNS |
denotes |
glycans |
T53208 |
11681-11683 |
IN |
denotes |
on |
T64129 |
11684-11688 |
NNS |
denotes |
MERS |
T13582 |
11689-11692 |
CC |
denotes |
and |
T84570 |
11693-11697 |
NNP |
denotes |
SARS |
T16671 |
11698-11699 |
NN |
denotes |
S |
T75686 |
11700-11708 |
NNS |
denotes |
proteins |
T33108 |
11710-11713 |
DT |
denotes |
The |
T5164 |
11714-11723 |
NN |
denotes |
modelling |
T85081 |
11724-11726 |
IN |
denotes |
of |
T78202 |
11727-11730 |
DT |
denotes |
the |
T60050 |
11731-11745 |
RB |
denotes |
experimentally |
T4820 |
11746-11754 |
VBN |
denotes |
observed |
T14194 |
11755-11768 |
NN |
denotes |
glycosylation |
T67945 |
11769-11771 |
VBZ |
denotes |
is |
T60933 |
11772-11783 |
VBN |
denotes |
illustrated |
T74928 |
11784-11786 |
IN |
denotes |
on |
T84730 |
11787-11790 |
DT |
denotes |
the |
T26156 |
11791-11800 |
NN |
denotes |
prefusion |
T35915 |
11801-11810 |
NN |
denotes |
structure |
T38149 |
11811-11813 |
IN |
denotes |
of |
T82839 |
11814-11822 |
JJ |
denotes |
trimeric |
T8210 |
11823-11824 |
DT |
denotes |
a |
T24421 |
11825-11829 |
NN |
denotes |
MERS |
T35489 |
11830-11831 |
NN |
denotes |
S |
T78652 |
11832-11833 |
-LRB- |
denotes |
( |
T68425 |
11833-11836 |
NN |
denotes |
PDB |
T70607 |
11837-11839 |
NN |
denotes |
ID |
T28784 |
11840-11844 |
NN |
denotes |
5X59 |
T45890 |
11844-11845 |
-RRB- |
denotes |
) |
T7560 |
11845-11851 |
CD |
denotes |
11 and |
T76185 |
11852-11853 |
NN |
denotes |
b |
T79009 |
11854-11858 |
NNP |
denotes |
SARS |
T30776 |
11859-11860 |
NNP |
denotes |
S |
T73014 |
11861-11862 |
-LRB- |
denotes |
( |
T68521 |
11862-11865 |
NN |
denotes |
PDB |
T15706 |
11866-11868 |
NN |
denotes |
ID |
T11708 |
11869-11873 |
NN |
denotes |
5X58 |
T3010 |
11873-11874 |
-RRB- |
denotes |
) |
T27583 |
11874-11908 |
JJ |
denotes |
11 glycoproteins. Structural-based |
T28741 |
11909-11916 |
NN |
denotes |
mapping |
T83177 |
11917-11919 |
IN |
denotes |
of |
T70681 |
11920-11928 |
JJ |
denotes |
N-linked |
T92110 |
11929-11936 |
NNS |
denotes |
glycans |
T35748 |
11937-11939 |
IN |
denotes |
on |
T9158 |
11940-11941 |
DT |
denotes |
a |
T59935 |
11942-11946 |
NN |
denotes |
MERS |
T12304 |
11947-11950 |
CC |
denotes |
and |
T82313 |
11951-11952 |
NN |
denotes |
b |
T61347 |
11953-11957 |
NNP |
denotes |
SARS |
T24930 |
11958-11959 |
NNP |
denotes |
S |
T68640 |
11960-11968 |
NNS |
denotes |
proteins |
T58506 |
11970-11973 |
DT |
denotes |
The |
T30217 |
11974-11983 |
NN |
denotes |
modelling |
T24446 |
11984-11986 |
IN |
denotes |
of |
T64701 |
11987-11990 |
DT |
denotes |
the |
T32032 |
11991-12005 |
RB |
denotes |
experimentally |
T87865 |
12006-12014 |
VBN |
denotes |
observed |
T41472 |
12015-12028 |
NN |
denotes |
glycosylation |
T75169 |
12029-12031 |
VBZ |
denotes |
is |
T85671 |
12032-12043 |
VBN |
denotes |
illustrated |
T14723 |
12044-12046 |
IN |
denotes |
on |
T33006 |
12047-12050 |
DT |
denotes |
the |
T74197 |
12051-12060 |
NN |
denotes |
prefusion |
T74594 |
12061-12070 |
NN |
denotes |
structure |
T32963 |
12071-12073 |
IN |
denotes |
of |
T41739 |
12074-12082 |
JJ |
denotes |
trimeric |
T10224 |
12083-12087 |
NNS |
denotes |
MERS |
T21879 |
12088-12089 |
NN |
denotes |
S |
T97449 |
12090-12091 |
-LRB- |
denotes |
( |
T53301 |
12091-12094 |
NN |
denotes |
PDB |
T9349 |
12095-12097 |
NN |
denotes |
ID |
T99864 |
12098-12102 |
NN |
denotes |
5X59 |
T96751 |
12102-12103 |
-RRB- |
denotes |
) |
T41923 |
12103-12105 |
CD |
denotes |
11 |
T4404 |
12106-12109 |
CC |
denotes |
and |
T91868 |
12110-12114 |
NNP |
denotes |
SARS |
T72317 |
12115-12116 |
NNP |
denotes |
S |
T2448 |
12117-12118 |
-LRB- |
denotes |
( |
T71010 |
12118-12121 |
NN |
denotes |
PDB |
T12743 |
12122-12124 |
NN |
denotes |
ID |
T88079 |
12125-12129 |
NN |
denotes |
5X58 |
T86576 |
12129-12130 |
-RRB- |
denotes |
) |
T3017 |
12130-12132 |
CD |
denotes |
11 |
T99799 |
12133-12146 |
NNS |
denotes |
glycoproteins |
T93818 |
12148-12151 |
DT |
denotes |
The |
T88390 |
12152-12159 |
NNS |
denotes |
glycans |
T27490 |
12160-12163 |
VBP |
denotes |
are |
T93961 |
12164-12171 |
VBN |
denotes |
colored |
T72784 |
12172-12181 |
VBG |
denotes |
according |
T77097 |
12182-12184 |
TO |
denotes |
to |
T64192 |
12185-12197 |
NN |
denotes |
oligomannose |
T65168 |
12198-12205 |
NN |
denotes |
content |
T6760 |
12205-12206 |
-COMMA- |
denotes |
, |
T9745 |
12207-12209 |
IN |
denotes |
as |
T86418 |
12210-12217 |
VBN |
denotes |
defined |
T30404 |
12218-12220 |
IN |
denotes |
by |
T37495 |
12221-12224 |
DT |
denotes |
the |
T79747 |
12225-12228 |
NN |
denotes |
key |
T59664 |
12230-12234 |
NN |
denotes |
DPP4 |
T85817 |
12235-12251 |
JJ |
denotes |
receptor-binding |
T40508 |
12252-12257 |
NNS |
denotes |
sites |
T52910 |
12258-12261 |
CC |
denotes |
and |
T7086 |
12262-12266 |
NN |
denotes |
ACE2 |
T75407 |
12267-12283 |
JJ |
denotes |
receptor-binding |
T46887 |
12284-12289 |
NNS |
denotes |
sites |
T73267 |
12290-12293 |
IN |
denotes |
for |
T33037 |
12294-12298 |
NNS |
denotes |
MERS |
T82290 |
12299-12302 |
CC |
denotes |
and |
T38470 |
12303-12307 |
NNS |
denotes |
SARS |
T11920 |
12307-12308 |
-COMMA- |
denotes |
, |
T13712 |
12309-12321 |
RB |
denotes |
respectively |
T3547 |
12321-12322 |
-COMMA- |
denotes |
, |
T34630 |
12323-12326 |
VBP |
denotes |
are |
T48779 |
12327-12336 |
VBN |
denotes |
indicated |
T50978 |
12337-12339 |
IN |
denotes |
in |
T62580 |
12340-12345 |
NN |
denotes |
light |
T99144 |
12346-12350 |
NN |
denotes |
blue |
T43036 |
12352-12355 |
DT |
denotes |
The |
T72864 |
12356-12358 |
NN |
denotes |
S1 |
T60407 |
12359-12362 |
CC |
denotes |
and |
T63087 |
12363-12365 |
NN |
denotes |
S2 |
T35349 |
12366-12374 |
NNS |
denotes |
subunits |
T29813 |
12375-12378 |
VBP |
denotes |
are |
T72291 |
12379-12386 |
VBN |
denotes |
colored |
T28888 |
12387-12392 |
JJ |
denotes |
light |
T2559 |
12393-12397 |
JJ |
denotes |
grey |
T24147 |
12398-12401 |
CC |
denotes |
and |
T73178 |
12402-12406 |
JJ |
denotes |
dark |
T95495 |
12407-12411 |
NN |
denotes |
grey |
T87030 |
12411-12412 |
-COMMA- |
denotes |
, |
T42416 |
12413-12425 |
RB |
denotes |
respectively |
T86019 |
12427-12431 |
NNP |
denotes |
Fig. |
T3693 |
12432-12433 |
CD |
denotes |
4 |
T11619 |
12434-12444 |
JJ |
denotes |
Amino-acid |
T79527 |
12445-12453 |
NN |
denotes |
sequence |
T16112 |
12454-12469 |
NN |
denotes |
diversification |
T17730 |
12470-12476 |
IN |
denotes |
across |
T51516 |
12477-12481 |
NNS |
denotes |
SARS |
T64040 |
12482-12485 |
CC |
denotes |
and |
T54827 |
12486-12490 |
NNS |
denotes |
MERS |
T40726 |
12491-12497 |
NNS |
denotes |
spikes |
T4452 |
12499-12500 |
DT |
denotes |
a |
T8758 |
12501-12511 |
JJ |
denotes |
Amino-acid |
T82356 |
12512-12521 |
NN |
denotes |
diversity |
T87134 |
12522-12524 |
IN |
denotes |
in |
T33615 |
12525-12529 |
NNS |
denotes |
SARS |
T87940 |
12530-12533 |
CC |
denotes |
and |
T96992 |
12534-12538 |
NNS |
denotes |
MERS |
T74428 |
12539-12540 |
NN |
denotes |
S |
T21364 |
12541-12545 |
NN |
denotes |
gene |
T75679 |
12546-12555 |
NNS |
denotes |
sequences |
T91293 |
12557-12565 |
JJ |
denotes |
Averaged |
T25884 |
12566-12572 |
NNS |
denotes |
values |
T75654 |
12573-12576 |
IN |
denotes |
for |
T60028 |
12577-12581 |
DT |
denotes |
each |
T46478 |
12582-12588 |
NN |
denotes |
domain |
T85913 |
12589-12592 |
VBP |
denotes |
are |
T30619 |
12593-12597 |
RB |
denotes |
also |
T89591 |
12598-12603 |
VBN |
denotes |
shown |
T64910 |
12604-12610 |
IN |
denotes |
below. |
T95898 |
12611-12612 |
NN |
denotes |
b |
T29035 |
12613-12623 |
NN |
denotes |
Comparison |
T92542 |
12624-12626 |
IN |
denotes |
of |
T58043 |
12627-12632 |
NN |
denotes |
dN/dS |
T67622 |
12633-12639 |
NNS |
denotes |
values |
T30617 |
12640-12647 |
IN |
denotes |
between |
T22042 |
12648-12654 |
VBN |
denotes |
buried |
T36252 |
12655-12658 |
CC |
denotes |
and |
T14068 |
12659-12666 |
VBN |
denotes |
exposed |
T83973 |
12667-12675 |
NNS |
denotes |
residues |
T81366 |
12676-12682 |
IN |
denotes |
across |
T80856 |
12683-12687 |
NNS |
denotes |
SARS |
T94093 |
12688-12691 |
CC |
denotes |
and |
T51534 |
12692-12696 |
NN |
denotes |
MERS |
T9382 |
12697-12698 |
NN |
denotes |
S |
T63910 |
12699-12700 |
-LRB- |
denotes |
( |
T13185 |
12700-12706 |
NN |
denotes |
n = 70 |
T50573 |
12707-12710 |
CC |
denotes |
and |
T62404 |
12711-12714 |
CD |
denotes |
100 |
T29922 |
12715-12718 |
IN |
denotes |
for |
T86628 |
12719-12723 |
NNS |
denotes |
SARS |
T87992 |
12724-12727 |
CC |
denotes |
and |
T96551 |
12728-12732 |
NNS |
denotes |
MERS |
T85872 |
12732-12733 |
-COMMA- |
denotes |
, |
T62342 |
12734-12746 |
RB |
denotes |
respectively |
T97022 |
12746-12747 |
-RRB- |
denotes |
) |
T33742 |
12749-12752 |
DT |
denotes |
The |
T17721 |
12753-12758 |
NN |
denotes |
error |
T64712 |
12759-12763 |
NNS |
denotes |
bars |
T7069 |
12764-12774 |
VBP |
denotes |
correspond |
T41089 |
12775-12777 |
TO |
denotes |
to |
T11597 |
12778-12781 |
DT |
denotes |
the |
T53375 |
12782-12784 |
CD |
denotes |
95 |
T27417 |
12784-12785 |
NN |
denotes |
% |
T18198 |
12786-12793 |
JJS |
denotes |
highest |
T80529 |
12794-12803 |
JJ |
denotes |
posterior |
T94719 |
12804-12811 |
NN |
denotes |
density |
T43156 |
12812-12821 |
NNS |
denotes |
intervals |
T2785 |
12822-12827 |
IN |
denotes |
while |
T81755 |
12828-12831 |
DT |
denotes |
the |
T65616 |
12832-12839 |
NNS |
denotes |
circles |
T83825 |
12840-12848 |
VBP |
denotes |
indicate |
T80900 |
12849-12853 |
JJ |
denotes |
mean |
T50642 |
12854-12859 |
NN |
denotes |
dN/dS |
T43870 |
12860-12867 |
NN |
denotes |
values. |
T97958 |
12868-12869 |
NN |
denotes |
c |
T94857 |
12870-12877 |
NN |
denotes |
Mapping |
T13865 |
12878-12880 |
IN |
denotes |
of |
T77796 |
12881-12884 |
DT |
denotes |
the |
T59041 |
12885-12888 |
IN |
denotes |
per |
T69745 |
12889-12896 |
NN |
denotes |
residue |
T70132 |
12897-12907 |
JJ |
denotes |
amino-acid |
T1949 |
12908-12917 |
NN |
denotes |
diversity |
T35196 |
12918-12923 |
VBN |
denotes |
shown |
T48789 |
12924-12926 |
IN |
denotes |
in |
T26990 |
12927-12928 |
NN |
denotes |
A |
T42572 |
12929-12933 |
IN |
denotes |
onto |
T79273 |
12934-12937 |
DT |
denotes |
the |
T68609 |
12938-12948 |
NNS |
denotes |
structures |
T73775 |
12949-12951 |
IN |
denotes |
of |
T46831 |
12952-12956 |
NNP |
denotes |
SARS |
T85214 |
12957-12960 |
CC |
denotes |
and |
T4847 |
12961-12965 |
NN |
denotes |
MERS |
T77242 |
12966-12967 |
NN |
denotes |
S |
T29063 |
12968-12969 |
-LRB- |
denotes |
( |
T96403 |
12969-12972 |
NN |
denotes |
PDB |
T2424 |
12973-12975 |
NN |
denotes |
ID |
T43233 |
12976-12980 |
NN |
denotes |
5X58 |
T31301 |
12981-12984 |
CC |
denotes |
and |
T77506 |
12985-12989 |
NN |
denotes |
5X59 |
T73600 |
12989-12990 |
-COMMA- |
denotes |
, |
T42948 |
12991-13003 |
RB |
denotes |
respectively |
T46741 |
13003-13004 |
-RRB- |
denotes |
) |
T67973 |
13004-13006 |
CD |
denotes |
11 |
T54383 |
13008-13009 |
NN |
denotes |
S |
T54985 |
13010-13018 |
NNS |
denotes |
proteins |
T71503 |
13019-13022 |
VBP |
denotes |
are |
T68699 |
13023-13032 |
VBN |
denotes |
presented |
T41652 |
13033-13035 |
IN |
denotes |
as |
T94309 |
13036-13044 |
NN |
denotes |
backbone |
T38232 |
13045-13051 |
NNS |
denotes |
traces |
T35432 |
13052-13056 |
IN |
denotes |
with |
T7775 |
13057-13065 |
NNS |
denotes |
residues |
T17162 |
13066-13073 |
VBN |
denotes |
colored |
T49747 |
13074-13083 |
VBG |
denotes |
according |
T59844 |
13084-13086 |
TO |
denotes |
to |
T16213 |
13087-13097 |
JJ |
denotes |
amino-acid |
T58864 |
13098-13107 |
NN |
denotes |
diversity |
T92910 |
13109-13117 |
NNS |
denotes |
Residues |
T14256 |
13118-13122 |
IN |
denotes |
with |
T40837 |
13123-13131 |
JJ |
denotes |
elevated |
T80639 |
13132-13141 |
NN |
denotes |
diversity |
T85890 |
13142-13145 |
VBP |
denotes |
are |
T71146 |
13146-13153 |
VBN |
denotes |
colored |
T5339 |
13154-13156 |
IN |
denotes |
in |
T28847 |
13157-13160 |
JJ |
denotes |
red |
T85163 |
13160-13161 |
-COMMA- |
denotes |
, |
T69312 |
13162-13165 |
CC |
denotes |
and |
T87041 |
13166-13174 |
VBN |
denotes |
N-linked |
T76860 |
13175-13182 |
NNS |
denotes |
glycans |
T24256 |
13183-13186 |
VBP |
denotes |
are |
T12192 |
13187-13196 |
VBN |
denotes |
presented |
T65467 |
13197-13199 |
IN |
denotes |
as |
T23895 |
13200-13205 |
JJ |
denotes |
white |
T99373 |
13206-13214 |
NNS |
denotes |
surfaces |
T72420 |
13216-13229 |
RB |
denotes |
Interestingly |
T27935 |
13229-13230 |
-COMMA- |
denotes |
, |
T18688 |
13231-13235 |
NN |
denotes |
SARS |
T54076 |
13236-13239 |
CC |
denotes |
and |
T91777 |
13240-13244 |
NN |
denotes |
HKU1 |
T82660 |
13245-13246 |
-LRB- |
denotes |
( |
T80158 |
13246-13248 |
NN |
denotes |
SI |
T18287 |
13249-13255 |
NN |
denotes |
Fig. 2 |
T26450 |
13255-13256 |
-RRB- |
denotes |
) |
T22664 |
13257-13258 |
NN |
denotes |
S |
T70221 |
13259-13267 |
NNS |
denotes |
proteins |
T8587 |
13268-13271 |
VBD |
denotes |
did |
T40209 |
13272-13275 |
RB |
denotes |
not |
T90081 |
13276-13283 |
VB |
denotes |
exhibit |
T47005 |
13284-13292 |
JJ |
denotes |
specific |
T66164 |
13293-13300 |
NN |
denotes |
mannose |
T5302 |
13301-13309 |
NNS |
denotes |
clusters |
T65310 |
13310-13314 |
WDT |
denotes |
that |
T95555 |
13315-13325 |
VBP |
denotes |
contribute |
T21512 |
13326-13328 |
TO |
denotes |
to |
T23601 |
13329-13332 |
DT |
denotes |
the |
T71479 |
13333-13340 |
JJ |
denotes |
overall |
T61001 |
13341-13348 |
NN |
denotes |
mannose |
T26227 |
13349-13358 |
NN |
denotes |
abundance |
T25050 |
13358-13359 |
-COMMA- |
denotes |
, |
T74525 |
13360-13363 |
CC |
denotes |
but |
T56258 |
13364-13368 |
RB |
denotes |
only |
T89329 |
13369-13377 |
VBN |
denotes |
isolated |
T54715 |
13378-13385 |
NNS |
denotes |
glycans |
T15304 |
13386-13390 |
VBD |
denotes |
were |
T81576 |
13391-13405 |
VBN |
denotes |
underprocessed |
T37031 |
13407-13409 |
PRP |
denotes |
We |
T11037 |
13410-13419 |
VBP |
denotes |
speculate |
T78740 |
13420-13424 |
IN |
denotes |
that |
T57941 |
13425-13428 |
DT |
denotes |
the |
T83472 |
13429-13446 |
JJ |
denotes |
oligomannose-type |
T62928 |
13447-13454 |
NNS |
denotes |
glycans |
T41459 |
13455-13459 |
RB |
denotes |
here |
T13983 |
13460-13465 |
VBP |
denotes |
arise |
T30720 |
13466-13470 |
IN |
denotes |
from |
T96574 |
13471-13487 |
JJ |
denotes |
protein-directed |
T55170 |
13488-13498 |
NN |
denotes |
inhibition |
T33234 |
13499-13501 |
IN |
denotes |
of |
T39535 |
13502-13508 |
NN |
denotes |
glycan |
T17864 |
13509-13519 |
NN |
denotes |
processing |
T15475 |
13519-13520 |
-COMMA- |
denotes |
, |
T10659 |
13521-13523 |
IN |
denotes |
as |
T1566 |
13524-13531 |
VBN |
denotes |
opposed |
T58559 |
13532-13534 |
TO |
denotes |
to |
T23943 |
13535-13538 |
DT |
denotes |
the |
T52429 |
13539-13556 |
JJ |
denotes |
glycan-influenced |
T84994 |
13557-13567 |
NN |
denotes |
processing |
T28395 |
13568-13576 |
VBN |
denotes |
observed |
T8259 |
13577-13579 |
IN |
denotes |
on |
T19314 |
13580-13584 |
NNS |
denotes |
MERS |
T3743 |
13586-13597 |
RB |
denotes |
Importantly |
T69555 |
13597-13598 |
-COMMA- |
denotes |
, |
T70877 |
13599-13616 |
JJ |
denotes |
oligomannose-type |
T68539 |
13617-13624 |
NNS |
denotes |
glycans |
T79414 |
13625-13628 |
VBZ |
denotes |
has |
T32823 |
13629-13633 |
RB |
denotes |
also |
T22023 |
13634-13638 |
VBN |
denotes |
been |
T1963 |
13639-13649 |
VBN |
denotes |
implicated |
T31422 |
13650-13652 |
IN |
denotes |
in |
T32938 |
13653-13659 |
JJ |
denotes |
innate |
T8288 |
13660-13666 |
JJ |
denotes |
immune |
T72195 |
13667-13678 |
NN |
denotes |
recognition |
T78182 |
13679-13681 |
IN |
denotes |
of |
T13186 |
13682-13695 |
NNS |
denotes |
coronaviruses |
T90164 |
13696-13698 |
IN |
denotes |
by |
T84232 |
13699-13711 |
NN |
denotes |
lectins47,48 |
T65100 |
13712-13716 |
WDT |
denotes |
that |
T10378 |
13717-13726 |
VBP |
denotes |
recognise |
T13519 |
13727-13732 |
DT |
denotes |
these |
T42882 |
13733-13747 |
VBN |
denotes |
underprocessed |
T52825 |
13748-13755 |
NNS |
denotes |
glycans |
T46370 |
13756-13758 |
IN |
denotes |
as |
T72183 |
13759-13778 |
JJ |
denotes |
pathogen-associated |
T32276 |
13779-13788 |
JJ |
denotes |
molecular |
T39921 |
13789-13797 |
NNS |
denotes |
patterns |
T46731 |
13799-13804 |
VBN |
denotes |
Given |
T24648 |
13805-13809 |
IN |
denotes |
that |
T45765 |
13810-13813 |
DT |
denotes |
the |
T56881 |
13814-13830 |
JJ |
denotes |
receptor-binding |
T98112 |
13831-13837 |
NN |
denotes |
domain |
T74716 |
13838-13840 |
VBZ |
denotes |
is |
T85598 |
13841-13844 |
DT |
denotes |
the |
T16051 |
13845-13849 |
JJ |
denotes |
main |
T58379 |
13850-13856 |
NN |
denotes |
target |
T53325 |
13857-13859 |
IN |
denotes |
of |
T7859 |
13860-13872 |
VBG |
denotes |
neutralising |
T26958 |
13873-13884 |
NN |
denotes |
antibodies8 |
T7334 |
13884-13885 |
-COMMA- |
denotes |
, |
T85070 |
13886-13888 |
PRP |
denotes |
it |
T1822 |
13889-13891 |
VBZ |
denotes |
is |
T40337 |
13892-13902 |
JJ |
denotes |
surprising |
T90378 |
13903-13907 |
IN |
denotes |
that |
T34257 |
13908-13911 |
DT |
denotes |
the |
T66548 |
13912-13916 |
NN |
denotes |
DPP4 |
T75367 |
13917-13933 |
JJ |
denotes |
receptor-binding |
T76130 |
13934-13938 |
NN |
denotes |
site |
T72556 |
13939-13941 |
IN |
denotes |
of |
T49036 |
13942-13946 |
NNS |
denotes |
MERS |
T45911 |
13947-13948 |
NN |
denotes |
S |
T21250 |
13949-13952 |
VBD |
denotes |
was |
T8376 |
13953-13956 |
RB |
denotes |
not |
T2696 |
13957-13965 |
VBN |
denotes |
occluded |
T90865 |
13966-13968 |
IN |
denotes |
by |
T29223 |
13969-13976 |
NNS |
denotes |
glycans |
T85418 |
13977-13978 |
-LRB- |
denotes |
( |
T83410 |
13978-13985 |
NN |
denotes |
Fig. 3a |
T92859 |
13985-13986 |
-RRB- |
denotes |
) |
T98108 |
13986-13987 |
-COMMA- |
denotes |
, |
T94718 |
13988-13990 |
IN |
denotes |
as |
T75995 |
13991-13999 |
VBN |
denotes |
observed |
T33346 |
14000-14003 |
IN |
denotes |
for |
T37727 |
14004-14009 |
JJ |
denotes |
other |
T65600 |
14010-14026 |
JJ |
denotes |
receptor-binding |
T6494 |
14027-14032 |
NNS |
denotes |
sites |
T57622 |
14033-14035 |
IN |
denotes |
of |
T15659 |
14036-14041 |
NN |
denotes |
class |
T77211 |
14042-14043 |
CD |
denotes |
I |
T77114 |
14044-14049 |
JJ |
denotes |
viral |
T21676 |
14050-14056 |
NN |
denotes |
fusion |
T55295 |
14057-14065 |
NNS |
denotes |
proteins |
T74940 |
14065-14066 |
-COMMA- |
denotes |
, |
T82828 |
14067-14076 |
VBG |
denotes |
including |
T94991 |
14077-14081 |
NNP |
denotes |
SARS |
T30576 |
14082-14083 |
NNP |
denotes |
S |
T72214 |
14084-14085 |
-LRB- |
denotes |
( |
T78031 |
14085-14092 |
NN |
denotes |
Fig. 3b |
T67457 |
14092-14093 |
-RRB- |
denotes |
) |
T6464 |
14093-14094 |
-COMMA- |
denotes |
, |
T4572 |
14095-14100 |
NN |
denotes |
HIV-1 |
T27072 |
14101-14106 |
NN |
denotes |
Env49 |
T51710 |
14106-14107 |
-COMMA- |
denotes |
, |
T37781 |
14108-14112 |
NN |
denotes |
LASV |
T43889 |
14113-14118 |
NN |
denotes |
GPC24 |
T95596 |
14119-14122 |
CC |
denotes |
and |
T81584 |
14123-14132 |
NN |
denotes |
influenza |
T23338 |
14133-14137 |
NN |
denotes |
HA50 |
T38368 |
14139-14141 |
PRP |
denotes |
We |
T7627 |
14142-14149 |
VBP |
denotes |
suggest |
T64380 |
14150-14154 |
IN |
denotes |
that |
T64096 |
14155-14159 |
DT |
denotes |
this |
T56477 |
14160-14162 |
VBZ |
denotes |
is |
T19767 |
14163-14169 |
RB |
denotes |
likely |
T70981 |
14170-14173 |
JJ |
denotes |
due |
T34848 |
14174-14176 |
TO |
denotes |
to |
T31069 |
14177-14180 |
DT |
denotes |
the |
T33383 |
14181-14190 |
JJ |
denotes |
intrinsic |
T53788 |
14191-14204 |
NN |
denotes |
functionality |
T92413 |
14205-14207 |
IN |
denotes |
of |
T48963 |
14208-14211 |
DT |
denotes |
the |
T14314 |
14212-14228 |
JJ |
denotes |
receptor-binding |
T65172 |
14229-14235 |
NN |
denotes |
domain |
T24472 |
14236-14238 |
IN |
denotes |
of |
T66405 |
14239-14243 |
NNP |
denotes |
MERS |
T3759 |
14244-14245 |
NNP |
denotes |
S |
T35971 |
14245-14246 |
-COMMA- |
denotes |
, |
T63119 |
14247-14251 |
WDT |
denotes |
that |
T19398 |
14252-14257 |
MD |
denotes |
would |
T5062 |
14258-14260 |
VB |
denotes |
be |
T26453 |
14261-14271 |
RB |
denotes |
sterically |
T99830 |
14272-14280 |
VBN |
denotes |
hindered |
T79196 |
14281-14283 |
IN |
denotes |
by |
T29715 |
14284-14287 |
DT |
denotes |
the |
T15993 |
14288-14296 |
NN |
denotes |
presence |
T46581 |
14297-14299 |
IN |
denotes |
of |
T41531 |
14300-14308 |
JJ |
denotes |
N-linked |
T84168 |
14309-14316 |
NNS |
denotes |
glycans |
T31775 |
14316-14317 |
-COMMA- |
denotes |
, |
T73121 |
14318-14325 |
IN |
denotes |
whereas |
T8489 |
14326-14331 |
JJ |
denotes |
other |
T86129 |
14332-14339 |
NNS |
denotes |
viruses |
T10448 |
14340-14343 |
VBP |
denotes |
are |
T85155 |
14344-14348 |
JJ |
denotes |
able |
T10897 |
14349-14351 |
TO |
denotes |
to |
T93372 |
14352-14363 |
VB |
denotes |
accommodate |
T42685 |
14364-14367 |
DT |
denotes |
the |
T16612 |
14368-14386 |
JJ |
denotes |
post-translational |
T29096 |
14387-14400 |
NNS |
denotes |
modifications |
T68645 |
14400-14401 |
-COMMA- |
denotes |
, |
T93438 |
14402-14409 |
IN |
denotes |
without |
T18466 |
14410-14417 |
RB |
denotes |
greatly |
T85948 |
14418-14428 |
VBG |
denotes |
perturbing |
T35584 |
14429-14442 |
NN |
denotes |
functionality |
T9810 |
14445-14453 |
NN |
denotes |
Sequence |
T60681 |
14454-14469 |
NN |
denotes |
diversification |
T14534 |
14470-14472 |
IN |
denotes |
of |
T70071 |
14473-14476 |
NN |
denotes |
CoV |
T46208 |
14477-14483 |
NNS |
denotes |
spikes |
T65633 |
14484-14486 |
PRP |
denotes |
We |
T71210 |
14487-14499 |
VBD |
denotes |
hypothesized |
T65773 |
14500-14504 |
IN |
denotes |
that |
T55109 |
14505-14523 |
JJ |
denotes |
solvent-accessible |
T1585 |
14523-14524 |
-COMMA- |
denotes |
, |
T39672 |
14525-14535 |
JJ |
denotes |
amino-acid |
T20594 |
14536-14544 |
NNS |
denotes |
residues |
T55010 |
14545-14547 |
IN |
denotes |
on |
T92344 |
14548-14549 |
NN |
denotes |
S |
T27449 |
14550-14558 |
NNS |
denotes |
proteins |
T7753 |
14559-14564 |
MD |
denotes |
would |
T87805 |
14565-14567 |
VB |
denotes |
be |
T76109 |
14568-14578 |
VBG |
denotes |
undergoing |
T49022 |
14579-14585 |
JJR |
denotes |
higher |
T38215 |
14586-14591 |
NNS |
denotes |
rates |
T48007 |
14592-14594 |
IN |
denotes |
of |
T86087 |
14595-14604 |
NNS |
denotes |
mutations |
T52952 |
14605-14613 |
VBN |
denotes |
compared |
T99241 |
14614-14618 |
IN |
denotes |
with |
T30950 |
14619-14625 |
JJ |
denotes |
buried |
T25052 |
14626-14634 |
NNS |
denotes |
residues |
T46492 |
14635-14638 |
CC |
denotes |
and |
T57528 |
14639-14646 |
NNS |
denotes |
regions |
T50177 |
14647-14651 |
WDT |
denotes |
that |
T46892 |
14652-14655 |
VBP |
denotes |
are |
T25102 |
14656-14664 |
VBN |
denotes |
occluded |
T44481 |
14665-14667 |
IN |
denotes |
by |
T18790 |
14668-14675 |
NNS |
denotes |
glycans |
T48178 |
14675-14676 |
-COMMA- |
denotes |
, |
T59110 |
14677-14682 |
WDT |
denotes |
which |
T61432 |
14683-14686 |
VBP |
denotes |
are |
T59632 |
14687-14693 |
JJ |
denotes |
unable |
T87545 |
14694-14696 |
TO |
denotes |
to |
T66630 |
14697-14699 |
VB |
denotes |
be |
T30435 |
14700-14708 |
VBN |
denotes |
targeted |
T87263 |
14709-14711 |
IN |
denotes |
by |
T84547 |
14712-14716 |
NN |
denotes |
host |
T42560 |
14717-14723 |
JJ |
denotes |
immune |
T4934 |
14724-14733 |
NNS |
denotes |
responses |
T73202 |
14735-14737 |
TO |
denotes |
To |
T86654 |
14738-14742 |
DT |
denotes |
that |
T62840 |
14743-14746 |
NN |
denotes |
end |
T60967 |
14746-14747 |
-COMMA- |
denotes |
, |
T58857 |
14748-14750 |
PRP |
denotes |
we |
T3483 |
14751-14760 |
VBD |
denotes |
performed |
T44308 |
14761-14763 |
DT |
denotes |
an |
T42487 |
14764-14774 |
NN |
denotes |
evaluation |
T38057 |
14775-14777 |
IN |
denotes |
of |
T40313 |
14778-14788 |
JJ |
denotes |
amino-acid |
T79756 |
14789-14804 |
NN |
denotes |
diversification |
T74853 |
14805-14807 |
IN |
denotes |
on |
T83914 |
14808-14809 |
DT |
denotes |
a |
T53700 |
14810-14826 |
JJ |
denotes |
residue-specific |
T63979 |
14827-14832 |
NN |
denotes |
level |
T62380 |
14832-14833 |
-COMMA- |
denotes |
, |
T6148 |
14834-14839 |
VBG |
denotes |
using |
T77953 |
14840-14848 |
RB |
denotes |
publicly |
T27779 |
14849-14858 |
JJ |
denotes |
available |
T83161 |
14859-14863 |
NN |
denotes |
gene |
T25304 |
14864-14873 |
NNS |
denotes |
sequences |
T83245 |
14874-14876 |
IN |
denotes |
of |
T52371 |
14877-14881 |
NNP |
denotes |
SARS |
T61083 |
14882-14885 |
CC |
denotes |
and |
T72419 |
14886-14890 |
NNP |
denotes |
MERS |
T42372 |
14891-14892 |
NNP |
denotes |
S |
T3167 |
14892-14893 |
-COMMA- |
denotes |
, |
T70472 |
14894-14899 |
WDT |
denotes |
which |
T16556 |
14900-14903 |
VBD |
denotes |
was |
T69286 |
14904-14914 |
VBN |
denotes |
calculated |
T52989 |
14915-14917 |
IN |
denotes |
as |
T29326 |
14918-14921 |
DT |
denotes |
the |
T41479 |
14922-14928 |
NN |
denotes |
number |
T1834 |
14929-14931 |
IN |
denotes |
of |
T51205 |
14932-14940 |
VBN |
denotes |
observed |
T91746 |
14941-14949 |
JJ |
denotes |
pairwise |
T46357 |
14950-14961 |
NNS |
denotes |
differences |
T17558 |
14962-14969 |
VBN |
denotes |
divided |
T41351 |
14970-14972 |
IN |
denotes |
by |
T50799 |
14973-14976 |
DT |
denotes |
the |
T28579 |
14977-14982 |
JJ |
denotes |
total |
T58945 |
14983-14989 |
NN |
denotes |
number |
T84292 |
14990-14992 |
IN |
denotes |
of |
T34101 |
14993-15001 |
JJ |
denotes |
pairwise |
T94055 |
15002-15013 |
NNS |
denotes |
comparisons |
T18701 |
15015-15022 |
RB |
denotes |
Firstly |
T74266 |
15022-15023 |
-COMMA- |
denotes |
, |
T36827 |
15024-15026 |
PRP |
denotes |
we |
T39186 |
15027-15032 |
VBD |
denotes |
found |
T6773 |
15033-15037 |
IN |
denotes |
that |
T13224 |
15038-15048 |
JJ |
denotes |
amino-acid |
T54008 |
15049-15058 |
NN |
denotes |
diversity |
T35302 |
15059-15062 |
VBD |
denotes |
was |
T93591 |
15063-15071 |
VBN |
denotes |
elevated |
T90961 |
15072-15074 |
IN |
denotes |
at |
T69090 |
15075-15080 |
VBN |
denotes |
known |
T86793 |
15081-15089 |
NNS |
denotes |
epitopes |
T61088 |
15090-15098 |
VBN |
denotes |
targeted |
T53019 |
15099-15101 |
IN |
denotes |
by |
T30461 |
15102-15114 |
VBG |
denotes |
neutralizing |
T32200 |
15115-15125 |
NNS |
denotes |
antibodies |
T83554 |
15125-15126 |
-COMMA- |
denotes |
, |
T32640 |
15127-15131 |
JJ |
denotes |
such |
T51281 |
15132-15134 |
IN |
denotes |
as |
T69890 |
15135-15138 |
DT |
denotes |
the |
T83248 |
15139-15149 |
JJ |
denotes |
N-terminal |
T49099 |
15150-15156 |
NN |
denotes |
domain |
T58919 |
15157-15160 |
CC |
denotes |
and |
T18721 |
15161-15164 |
DT |
denotes |
the |
T18570 |
15165-15181 |
JJ |
denotes |
receptor-binding |
T60790 |
15182-15189 |
NNS |
denotes |
domains |
T18812 |
15189-15190 |
-COMMA- |
denotes |
, |
T96660 |
15191-15194 |
CC |
denotes |
and |
T11216 |
15195-15202 |
VBN |
denotes |
reduced |
T27277 |
15203-15205 |
IN |
denotes |
in |
T89562 |
15206-15209 |
DT |
denotes |
the |
T7777 |
15210-15217 |
NNS |
denotes |
regions |
T23472 |
15218-15220 |
IN |
denotes |
in |
T66095 |
15221-15224 |
DT |
denotes |
the |
T52990 |
15225-15227 |
NN |
denotes |
S2 |
T69246 |
15228-15234 |
NN |
denotes |
domain |
T76095 |
15234-15235 |
-COMMA- |
denotes |
, |
T33023 |
15236-15240 |
JJ |
denotes |
such |
T94778 |
15241-15243 |
IN |
denotes |
as |
T12698 |
15244-15247 |
DT |
denotes |
the |
T82633 |
15248-15254 |
NN |
denotes |
fusion |
T75213 |
15255-15262 |
NN |
denotes |
peptide |
T29294 |
15262-15263 |
-COMMA- |
denotes |
, |
T28968 |
15264-15270 |
NN |
denotes |
heptad |
T29760 |
15271-15277 |
NN |
denotes |
repeat |
T53742 |
15278-15281 |
CD |
denotes |
one |
T18725 |
15281-15282 |
-COMMA- |
denotes |
, |
T43420 |
15283-15286 |
CC |
denotes |
and |
T34460 |
15287-15290 |
DT |
denotes |
the |
T26621 |
15291-15298 |
JJ |
denotes |
central |
T91466 |
15299-15304 |
NN |
denotes |
helix |
T93319 |
15305-15312 |
NNS |
denotes |
domains |
T88231 |
15312-15313 |
-COMMA- |
denotes |
, |
T49934 |
15314-15319 |
WDT |
denotes |
which |
T23715 |
15320-15323 |
VBP |
denotes |
are |
T33407 |
15324-15330 |
RB |
denotes |
likely |
T88882 |
15331-15338 |
JJ |
denotes |
subject |
T76117 |
15339-15341 |
TO |
denotes |
to |
T4874 |
15342-15349 |
JJR |
denotes |
greater |
T38302 |
15350-15360 |
JJ |
denotes |
functional |
T99472 |
15361-15372 |
NNS |
denotes |
constraints |
T34520 |
15373-15374 |
-LRB- |
denotes |
( |
T48991 |
15374-15381 |
NN |
denotes |
Fig. 4a |
T5319 |
15381-15382 |
-RRB- |
denotes |
) |
T69499 |
15384-15392 |
NN |
denotes |
Analysis |
T65163 |
15393-15395 |
IN |
denotes |
of |
T23395 |
15396-15399 |
DT |
denotes |
the |
T78947 |
15400-15408 |
JJ |
denotes |
relative |
T61369 |
15409-15414 |
NN |
denotes |
ratio |
T85886 |
15415-15417 |
IN |
denotes |
of |
T53309 |
15418-15432 |
JJ |
denotes |
non-synonymous |
T78726 |
15433-15435 |
TO |
denotes |
to |
T13118 |
15436-15446 |
JJ |
denotes |
synonymous |
T63573 |
15447-15457 |
NN |
denotes |
nucleotide |
T72369 |
15458-15471 |
NNS |
denotes |
substitutions |
T18378 |
15472-15473 |
-LRB- |
denotes |
( |
T58404 |
15473-15477 |
FW |
denotes |
i.e. |
T58779 |
15478-15483 |
NN |
denotes |
dN/dS |
T10324 |
15484-15490 |
NNS |
denotes |
ratios |
T30580 |
15490-15491 |
-RRB- |
denotes |
) |
T83087 |
15492-15500 |
VBD |
denotes |
revealed |
T2494 |
15501-15505 |
IN |
denotes |
that |
T4328 |
15506-15513 |
VBN |
denotes |
exposed |
T12652 |
15514-15522 |
NNS |
denotes |
residues |
T92287 |
15523-15532 |
VBD |
denotes |
exhibited |
T88501 |
15533-15546 |
RB |
denotes |
significantly |
T11718 |
15547-15553 |
JJR |
denotes |
higher |
T86795 |
15554-15559 |
NN |
denotes |
dN/dS |
T59603 |
15560-15566 |
NNS |
denotes |
values |
T7211 |
15567-15568 |
-LRB- |
denotes |
( |
T4769 |
15568-15575 |
NN |
denotes |
Fig. 4b |
T47239 |
15575-15576 |
-RRB- |
denotes |
) |
T90969 |
15578-15584 |
VBN |
denotes |
Buried |
T92849 |
15585-15593 |
NNS |
denotes |
residues |
T78244 |
15594-15596 |
IN |
denotes |
on |
T54331 |
15597-15601 |
NNS |
denotes |
SARS |
T42940 |
15602-15605 |
VBD |
denotes |
had |
T56294 |
15606-15610 |
JJ |
denotes |
mean |
T46802 |
15611-15616 |
NN |
denotes |
dN/dS |
T64331 |
15617-15623 |
NNS |
denotes |
ratios |
T35591 |
15624-15626 |
IN |
denotes |
of |
T4586 |
15627-15631 |
CD |
denotes |
0.31 |
T68155 |
15632-15640 |
VBN |
denotes |
compared |
T78948 |
15641-15645 |
IN |
denotes |
with |
T78585 |
15646-15650 |
CD |
denotes |
2.82 |
T27968 |
15651-15654 |
IN |
denotes |
for |
T96310 |
15655-15662 |
VBN |
denotes |
exposed |
T43288 |
15663-15670 |
NNS |
denotes |
resides |
T92960 |
15672-15680 |
RB |
denotes |
Likewise |
T14475 |
15680-15681 |
-COMMA- |
denotes |
, |
T32298 |
15682-15685 |
DT |
denotes |
the |
T12634 |
15686-15692 |
VBN |
denotes |
buried |
T80500 |
15693-15701 |
NNS |
denotes |
residues |
T77635 |
15702-15704 |
IN |
denotes |
on |
T24392 |
15705-15709 |
NNS |
denotes |
MERS |
T2961 |
15710-15713 |
VBD |
denotes |
had |
T6521 |
15714-15715 |
DT |
denotes |
a |
T8471 |
15716-15726 |
VBN |
denotes |
calculated |
T37460 |
15727-15732 |
NN |
denotes |
dN/dS |
T55408 |
15733-15738 |
NN |
denotes |
ratio |
T45120 |
15739-15741 |
IN |
denotes |
of |
T23381 |
15742-15746 |
CD |
denotes |
0.10 |
T30445 |
15747-15755 |
VBN |
denotes |
compared |
T55016 |
15756-15760 |
IN |
denotes |
with |
T1385 |
15761-15768 |
VBN |
denotes |
exposed |
T65828 |
15769-15777 |
NNS |
denotes |
residues |
T35353 |
15778-15782 |
IN |
denotes |
with |
T91154 |
15783-15784 |
DT |
denotes |
a |
T26380 |
15785-15790 |
NN |
denotes |
value |
T92544 |
15791-15793 |
IN |
denotes |
of |
T79406 |
15794-15798 |
CD |
denotes |
0.45 |
T92418 |
15800-15811 |
RB |
denotes |
Furthermore |
T91452 |
15811-15812 |
-COMMA- |
denotes |
, |
T84302 |
15813-15817 |
WRB |
denotes |
when |
T74584 |
15818-15826 |
JJ |
denotes |
per-site |
T76352 |
15827-15837 |
JJ |
denotes |
amino-acid |
T98451 |
15838-15849 |
NNS |
denotes |
diversities |
T72837 |
15850-15854 |
VBD |
denotes |
were |
T54724 |
15855-15861 |
VBN |
denotes |
mapped |
T45778 |
15862-15866 |
IN |
denotes |
onto |
T98923 |
15867-15870 |
DT |
denotes |
the |
T59533 |
15871-15876 |
RB |
denotes |
fully |
T25862 |
15877-15889 |
VBN |
denotes |
glycosylated |
T32515 |
15890-15900 |
JJ |
denotes |
structural |
T94405 |
15901-15906 |
NN |
denotes |
model |
T76643 |
15907-15909 |
IN |
denotes |
of |
T13755 |
15910-15913 |
DT |
denotes |
the |
T14482 |
15914-15924 |
JJ |
denotes |
respective |
T65032 |
15925-15928 |
NN |
denotes |
CoV |
T12704 |
15929-15930 |
NN |
denotes |
S |
T70323 |
15931-15939 |
NNS |
denotes |
proteins |
T33888 |
15940-15941 |
-LRB- |
denotes |
( |
T60190 |
15941-15948 |
NN |
denotes |
Fig. 4c |
T27628 |
15948-15949 |
-RRB- |
denotes |
) |
T87038 |
15949-15950 |
-COMMA- |
denotes |
, |
T49843 |
15951-15959 |
NNS |
denotes |
hotspots |
T77547 |
15960-15962 |
IN |
denotes |
of |
T63244 |
15963-15972 |
NNS |
denotes |
mutations |
T5765 |
15973-15977 |
VBD |
denotes |
were |
T8574 |
15978-15989 |
VBN |
denotes |
highlighted |
T21020 |
15990-15992 |
IN |
denotes |
on |
T89986 |
15993-15996 |
DT |
denotes |
the |
T65568 |
15997-16004 |
NN |
denotes |
protein |
T63130 |
16005-16012 |
NN |
denotes |
surface |
T96535 |
16013-16023 |
IN |
denotes |
throughout |
T21467 |
16024-16027 |
DT |
denotes |
the |
T66745 |
16028-16034 |
NN |
denotes |
trimer |
T45284 |
16035-16044 |
VBG |
denotes |
revealing |
T17381 |
16045-16054 |
JJ |
denotes |
extensive |
T55156 |
16055-16070 |
NNS |
denotes |
vulnerabilities |
T13067 |
16071-16081 |
VBG |
denotes |
permeating |
T40910 |
16082-16089 |
IN |
denotes |
through |
T14483 |
16090-16093 |
DT |
denotes |
the |
T29556 |
16094-16100 |
NN |
denotes |
glycan |
T94871 |
16101-16107 |
NN |
denotes |
shield |
T71413 |
16108-16110 |
IN |
denotes |
of |
T81413 |
16111-16115 |
NNS |
denotes |
SARS |
T68523 |
16116-16119 |
CC |
denotes |
and |
T70297 |
16120-16124 |
NNP |
denotes |
MERS |
T12679 |
16125-16129 |
NNP |
denotes |
CoVs |
T87216 |
16131-16133 |
PRP |
denotes |
It |
T15902 |
16134-16136 |
VBZ |
denotes |
is |
T6523 |
16137-16148 |
JJ |
denotes |
interesting |
T19232 |
16149-16151 |
TO |
denotes |
to |
T97839 |
16152-16156 |
VB |
denotes |
note |
T99309 |
16157-16160 |
DT |
denotes |
the |
T40498 |
16161-16165 |
NN |
denotes |
lack |
T81866 |
16166-16168 |
IN |
denotes |
of |
T9331 |
16169-16179 |
JJ |
denotes |
amino-acid |
T44303 |
16180-16189 |
NN |
denotes |
diversity |
T83531 |
16190-16192 |
IN |
denotes |
on |
T76133 |
16193-16196 |
DT |
denotes |
the |
T29918 |
16197-16213 |
JJ |
denotes |
receptor-binding |
T15412 |
16214-16221 |
NNS |
denotes |
domains |
T38048 |
16222-16224 |
IN |
denotes |
of |
T48648 |
16225-16229 |
NNS |
denotes |
MERS |
T31354 |
16230-16231 |
NN |
denotes |
S |
T92070 |
16232-16240 |
NNS |
denotes |
proteins |
T5507 |
16241-16245 |
WDT |
denotes |
that |
T19099 |
16246-16254 |
VBP |
denotes |
protrude |
T77842 |
16255-16259 |
RB |
denotes |
away |
T99218 |
16260-16264 |
IN |
denotes |
from |
T68020 |
16265-16268 |
DT |
denotes |
the |
T87267 |
16269-16276 |
NNS |
denotes |
glycans |
T55216 |
16278-16280 |
PRP |
denotes |
We |
T15548 |
16281-16286 |
MD |
denotes |
would |
T19328 |
16287-16294 |
VB |
denotes |
suggest |
T73414 |
16295-16299 |
IN |
denotes |
that |
T39503 |
16300-16304 |
DT |
denotes |
this |
T1176 |
16305-16308 |
MD |
denotes |
may |
T73192 |
16309-16315 |
VB |
denotes |
result |
T18164 |
16316-16320 |
IN |
denotes |
from |
T59646 |
16321-16324 |
DT |
denotes |
the |
T56626 |
16325-16334 |
JJ |
denotes |
intrinsic |
T77011 |
16335-16351 |
JJ |
denotes |
receptor-binding |
T13068 |
16352-16365 |
NN |
denotes |
functionality |
T25400 |
16366-16368 |
IN |
denotes |
of |
T95940 |
16369-16374 |
DT |
denotes |
these |
T4558 |
16375-16382 |
NNS |
denotes |
domains |
T85225 |
16384-16392 |
IN |
denotes |
Although |
T78299 |
16393-16398 |
NN |
denotes |
dN/dS |
T69491 |
16399-16408 |
NNS |
denotes |
estimates |
T17336 |
16409-16412 |
VBP |
denotes |
are |
T68738 |
16413-16423 |
JJ |
denotes |
comparable |
T29834 |
16424-16430 |
IN |
denotes |
within |
T7384 |
16431-16435 |
DT |
denotes |
each |
T38180 |
16436-16441 |
JJ |
denotes |
viral |
T14361 |
16442-16450 |
NN |
denotes |
outbreak |
T27804 |
16450-16451 |
-COMMA- |
denotes |
, |
T63927 |
16452-16456 |
PRP |
denotes |
they |
T40801 |
16457-16460 |
VBP |
denotes |
are |
T50374 |
16461-16464 |
RB |
denotes |
not |
T5187 |
16465-16473 |
RB |
denotes |
directly |
T67674 |
16474-16484 |
JJ |
denotes |
comparable |
T16791 |
16485-16492 |
IN |
denotes |
between |
T15216 |
16493-16498 |
JJ |
denotes |
viral |
T70745 |
16499-16507 |
NNS |
denotes |
families |
T5519 |
16508-16510 |
IN |
denotes |
as |
T39713 |
16511-16515 |
PRP |
denotes |
they |
T72942 |
16516-16519 |
MD |
denotes |
can |
T66143 |
16520-16524 |
RB |
denotes |
only |
T83434 |
16525-16527 |
VB |
denotes |
be |
T81231 |
16528-16538 |
VBN |
denotes |
considered |
T66257 |
16539-16541 |
IN |
denotes |
in |
T26996 |
16542-16545 |
DT |
denotes |
the |
T12587 |
16546-16557 |
NN |
denotes |
environment |
T55529 |
16558-16560 |
IN |
denotes |
in |
T94028 |
16561-16566 |
WDT |
denotes |
which |
T66921 |
16567-16571 |
PRP |
denotes |
they |
T48812 |
16572-16575 |
VBP |
denotes |
are |
T68204 |
16576-16584 |
VBN |
denotes |
measured |
T1345 |
16585-16586 |
-LRB- |
denotes |
( |
T50152 |
16586-16590 |
FW |
denotes |
i.e. |
T58234 |
16591-16599 |
JJ |
denotes |
multiple |
T20304 |
16600-16611 |
NNS |
denotes |
differences |
T57102 |
16612-16614 |
IN |
denotes |
in |
T44931 |
16615-16627 |
NN |
denotes |
transmission |
T48849 |
16628-16635 |
NN |
denotes |
ecology |
T40406 |
16636-16639 |
CC |
denotes |
and |
T86262 |
16640-16650 |
NN |
denotes |
host-virus |
T60225 |
16651-16663 |
NNS |
denotes |
interactions |
T28690 |
16664-16672 |
VBP |
denotes |
disallow |
T4001 |
16673-16683 |
JJ |
denotes |
meaningful |
T97622 |
16684-16695 |
NNS |
denotes |
comparisons |
T88580 |
16695-16696 |
-RRB- |
denotes |
) |
T61778 |
16698-16701 |
IN |
denotes |
For |
T80559 |
16702-16709 |
NN |
denotes |
example |
T85630 |
16709-16710 |
-COMMA- |
denotes |
, |
T13499 |
16711-16722 |
NNS |
denotes |
differences |
T59995 |
16723-16725 |
IN |
denotes |
in |
T19712 |
16726-16729 |
DT |
denotes |
the |
T30994 |
16730-16738 |
JJ |
denotes |
epidemic |
T28935 |
16739-16748 |
NN |
denotes |
behaviour |
T90583 |
16749-16752 |
CC |
denotes |
and |
T22228 |
16753-16757 |
NN |
denotes |
host |
T48983 |
16758-16764 |
JJ |
denotes |
immune |
T32345 |
16765-16776 |
NN |
denotes |
environment |
T33520 |
16777-16779 |
IN |
denotes |
of |
T49936 |
16780-16784 |
NNS |
denotes |
MERS |
T62735 |
16785-16788 |
CC |
denotes |
and |
T19591 |
16789-16793 |
NNP |
denotes |
SARS |
T85021 |
16794-16803 |
NNS |
denotes |
outbreaks |
T32139 |
16804-16810 |
RB |
denotes |
likely |
T6621 |
16811-16821 |
VBP |
denotes |
contribute |
T58427 |
16822-16824 |
TO |
denotes |
to |
T13399 |
16825-16828 |
DT |
denotes |
the |
T26807 |
16829-16837 |
VBN |
denotes |
observed |
T13552 |
16838-16845 |
JJ |
denotes |
genetic |
T43199 |
16846-16855 |
NN |
denotes |
diversity |
T65839 |
16856-16859 |
CC |
denotes |
and |
T79458 |
16860-16864 |
RB |
denotes |
thus |
T98636 |
16865-16870 |
NN |
denotes |
dN/dS |
T25443 |
16872-16876 |
NNS |
denotes |
MERS |
T97762 |
16877-16880 |
VBD |
denotes |
was |
T89667 |
16881-16894 |
VBN |
denotes |
characterized |
T47196 |
16895-16897 |
IN |
denotes |
by |
T18635 |
16898-16906 |
VBN |
denotes |
repeated |
T30054 |
16907-16916 |
NN |
denotes |
spillover |
T27860 |
16917-16923 |
NNS |
denotes |
events |
T14782 |
16924-16928 |
IN |
denotes |
from |
T25019 |
16929-16935 |
NNS |
denotes |
camels |
T86652 |
16936-16940 |
IN |
denotes |
into |
T1639 |
16941-16947 |
NNS |
denotes |
humans |
T23535 |
16947-16948 |
-COMMA- |
denotes |
, |
T51241 |
16949-16954 |
WRB |
denotes |
where |
T67194 |
16955-16957 |
PRP |
denotes |
it |
T59854 |
16958-16968 |
VBD |
denotes |
circulated |
T82528 |
16969-16980 |
RB |
denotes |
transiently |
T23126 |
16982-16984 |
IN |
denotes |
In |
T4625 |
16985-16993 |
NN |
denotes |
contrast |
T47309 |
16993-16994 |
-COMMA- |
denotes |
, |
T1278 |
16995-16998 |
DT |
denotes |
the |
T1279 |
16999-17003 |
NNP |
denotes |
SARS |
T1280 |
17004-17012 |
NN |
denotes |
outbreak |
T1281 |
17013-17025 |
VBD |
denotes |
corresponded |
T1282 |
17026-17028 |
TO |
denotes |
to |
T1283 |
17029-17030 |
DT |
denotes |
a |
T1284 |
17031-17037 |
JJ |
denotes |
single |
T1285 |
17038-17046 |
JJ |
denotes |
zoonotic |
T1286 |
17047-17052 |
NN |
denotes |
event |
T1287 |
17053-17061 |
VBN |
denotes |
followed |
T1288 |
17062-17064 |
IN |
denotes |
by |
T1289 |
17065-17074 |
JJ |
denotes |
extensive |
T1290 |
17075-17089 |
JJ |
denotes |
human-to-human |
T1291 |
17090-17102 |
NN |
denotes |
transmission |
T1292 |
17104-17116 |
RB |
denotes |
Consequently |
T1293 |
17116-17117 |
-COMMA- |
denotes |
, |
T1294 |
17118-17127 |
VBG |
denotes |
inferring |
T1295 |
17128-17131 |
DT |
denotes |
the |
T1296 |
17132-17138 |
NN |
denotes |
degree |
T1297 |
17139-17141 |
IN |
denotes |
of |
T1298 |
17142-17151 |
NN |
denotes |
selection |
T1299 |
17152-17158 |
VBG |
denotes |
acting |
T1300 |
17159-17163 |
IN |
denotes |
upon |
T1301 |
17164-17168 |
NNS |
denotes |
MERS |
T1302 |
17169-17172 |
CC |
denotes |
and |
T1303 |
17173-17177 |
NNS |
denotes |
SARS |
T1304 |
17178-17182 |
IN |
denotes |
from |
T1305 |
17183-17188 |
NN |
denotes |
dN/dS |
T1306 |
17189-17197 |
NN |
denotes |
analysis |
T1307 |
17198-17200 |
VBZ |
denotes |
is |
T1308 |
17201-17210 |
RB |
denotes |
extremely |
T1309 |
17211-17220 |
JJ |
denotes |
difficult |
T1310 |
17222-17233 |
RB |
denotes |
Importantly |
T1311 |
17233-17234 |
-COMMA- |
denotes |
, |
T1312 |
17235-17240 |
IN |
denotes |
while |
T1313 |
17241-17248 |
JJ |
denotes |
similar |
T1314 |
17249-17257 |
NNS |
denotes |
analyses |
T1315 |
17258-17260 |
IN |
denotes |
of |
T1316 |
17261-17271 |
NN |
denotes |
SARS-CoV-2 |
T1317 |
17272-17274 |
VBZ |
denotes |
is |
T1318 |
17275-17284 |
JJ |
denotes |
desirable |
T1319 |
17284-17285 |
-COMMA- |
denotes |
, |
T1320 |
17286-17289 |
JJ |
denotes |
due |
T1321 |
17290-17292 |
TO |
denotes |
to |
T1322 |
17293-17296 |
DT |
denotes |
the |
T1323 |
17297-17300 |
JJ |
denotes |
low |
T1324 |
17301-17308 |
JJ |
denotes |
genetic |
T1325 |
17309-17318 |
NN |
denotes |
variation |
T1326 |
17319-17324 |
IN |
denotes |
among |
T1327 |
17325-17328 |
DT |
denotes |
the |
T1328 |
17329-17336 |
JJ |
denotes |
current |
T1329 |
17337-17347 |
NN |
denotes |
SARS-CoV-2 |
T1330 |
17348-17357 |
NNS |
denotes |
sequences |
T1331 |
17358-17359 |
-LRB- |
denotes |
( |
T1332 |
17359-17361 |
IN |
denotes |
as |
T1333 |
17362-17364 |
IN |
denotes |
of |
T1334 |
17365-17367 |
CD |
denotes |
17 |
T1335 |
17368-17373 |
NNP |
denotes |
March |
T1336 |
17374-17378 |
CD |
denotes |
2020 |
T1337 |
17378-17379 |
-RRB- |
denotes |
) |
T1338 |
17379-17380 |
-COMMA- |
denotes |
, |
T1339 |
17381-17386 |
WDT |
denotes |
which |
T1340 |
17387-17393 |
RB |
denotes |
likely |
T1341 |
17394-17401 |
VBP |
denotes |
include |
T1342 |
17402-17413 |
JJ |
denotes |
deleterious |
T1343 |
17414-17423 |
NNS |
denotes |
mutations |
T1344 |
17424-17428 |
WDT |
denotes |
that |
T79570 |
17429-17433 |
MD |
denotes |
will |
T1346 |
17434-17436 |
VB |
denotes |
be |
T1347 |
17437-17444 |
VBN |
denotes |
removed |
T1348 |
17445-17447 |
IN |
denotes |
by |
T1349 |
17448-17457 |
NN |
denotes |
selection |
T1350 |
17458-17462 |
IN |
denotes |
over |
T1351 |
17463-17467 |
NN |
denotes |
time |
T1352 |
17467-17468 |
-COMMA- |
denotes |
, |
T1353 |
17469-17472 |
DT |
denotes |
the |
T1354 |
17473-17482 |
VBG |
denotes |
resulting |
T1355 |
17483-17496 |
JJ |
denotes |
bioinformatic |
T1356 |
17497-17505 |
NNS |
denotes |
analyses |
T1357 |
17506-17511 |
MD |
denotes |
would |
T1358 |
17512-17514 |
VB |
denotes |
be |
T1359 |
17515-17525 |
JJ |
denotes |
unreliable |
T1360 |
17528-17539 |
VBG |
denotes |
Visualising |
T1361 |
17540-17543 |
DT |
denotes |
the |
T1362 |
17544-17549 |
NN |
denotes |
HIV-1 |
T1363 |
17550-17553 |
CC |
denotes |
and |
T1364 |
17554-17558 |
NN |
denotes |
SARS |
T1365 |
17559-17565 |
NN |
denotes |
glycan |
T1366 |
17566-17573 |
NNS |
denotes |
shields |
T1367 |
17574-17576 |
IN |
denotes |
by |
T1368 |
17577-17584 |
NN |
denotes |
cryo-EM |
T8430 |
17585-17590 |
NN |
denotes |
HIV-1 |
T3174 |
17591-17594 |
NN |
denotes |
Env |
T27555 |
17595-17597 |
VBZ |
denotes |
is |
T55541 |
17598-17599 |
DT |
denotes |
a |
T20248 |
17600-17610 |
JJ |
denotes |
prototypic |
T67286 |
17611-17616 |
JJ |
denotes |
viral |
T69498 |
17617-17622 |
NN |
denotes |
class |
T3932 |
17623-17624 |
CD |
denotes |
I |
T49427 |
17625-17631 |
NN |
denotes |
fusion |
T80657 |
17632-17639 |
NN |
denotes |
protein |
T46816 |
17640-17644 |
WDT |
denotes |
that |
T99370 |
17645-17653 |
VBZ |
denotes |
exhibits |
T82158 |
17654-17663 |
JJ |
denotes |
extensive |
T40184 |
17664-17671 |
NN |
denotes |
surface |
T83381 |
17672-17685 |
NN |
denotes |
glycosylation |
T34922 |
17685-17686 |
-COMMA- |
denotes |
, |
T41135 |
17687-17696 |
VBG |
denotes |
resulting |
T52094 |
17697-17699 |
IN |
denotes |
in |
T41086 |
17700-17702 |
DT |
denotes |
an |
T24478 |
17703-17712 |
JJ |
denotes |
effective |
T12116 |
17713-17719 |
NN |
denotes |
glycan |
T66049 |
17720-17726 |
NN |
denotes |
shield |
T24089 |
17727-17729 |
TO |
denotes |
to |
T80516 |
17730-17733 |
VB |
denotes |
aid |
T40146 |
17734-17741 |
NN |
denotes |
evasion |
T31245 |
17742-17746 |
IN |
denotes |
from |
T10149 |
17747-17750 |
DT |
denotes |
the |
T79574 |
17751-17755 |
NN |
denotes |
host |
T93688 |
17756-17764 |
JJ |
denotes |
adaptive |
T94198 |
17765-17771 |
JJ |
denotes |
immune |
T10989 |
17772-17785 |
NN |
denotes |
response21,31 |
T32196 |
17787-17789 |
IN |
denotes |
In |
T81817 |
17790-17795 |
NN |
denotes |
order |
T91723 |
17796-17798 |
TO |
denotes |
to |
T52822 |
17799-17808 |
VB |
denotes |
visualize |
T6796 |
17809-17812 |
DT |
denotes |
the |
T38040 |
17813-17822 |
NN |
denotes |
structure |
T51236 |
17823-17825 |
IN |
denotes |
of |
T17574 |
17826-17829 |
DT |
denotes |
the |
T94895 |
17830-17840 |
JJ |
denotes |
respective |
T2313 |
17841-17847 |
NN |
denotes |
glycan |
T39465 |
17848-17857 |
NN |
denotes |
“shields” |
T63649 |
17858-17860 |
IN |
denotes |
of |
T97323 |
17861-17866 |
NN |
denotes |
HIV-1 |
T48816 |
17867-17870 |
CC |
denotes |
and |
T59243 |
17871-17875 |
NN |
denotes |
SARS |
T65533 |
17876-17887 |
NN |
denotes |
coronavirus |
T26306 |
17888-17890 |
PRP |
denotes |
we |
T89403 |
17891-17895 |
VBD |
denotes |
used |
T31852 |
17896-17911 |
JJ |
denotes |
single-particle |
T56676 |
17912-17925 |
NN |
denotes |
cryo-electron |
T27050 |
17926-17936 |
NN |
denotes |
microscopy |
T97416 |
17937-17938 |
-LRB- |
denotes |
( |
T56321 |
17938-17945 |
NN |
denotes |
cryo-EM |
T61586 |
17945-17946 |
-RRB- |
denotes |
) |
T32555 |
17948-17951 |
DT |
denotes |
The |
T47125 |
17952-17959 |
NNS |
denotes |
results |
T36239 |
17960-17963 |
IN |
denotes |
for |
T18889 |
17964-17969 |
NN |
denotes |
HIV-1 |
T12931 |
17970-17973 |
NN |
denotes |
Env |
T63067 |
17974-17978 |
VBD |
denotes |
were |
T30265 |
17979-17989 |
VBN |
denotes |
reproduced |
T57197 |
17990-17998 |
RB |
denotes |
directly |
T8292 |
17999-18003 |
IN |
denotes |
from |
T31650 |
18004-18012 |
NNP |
denotes |
Berndsen |
T37715 |
18013-18015 |
NNP |
denotes |
et |
T19388 |
18016-18021 |
NN |
denotes |
al.51 |
T9777 |
18022-18027 |
IN |
denotes |
while |
T55752 |
18028-18031 |
DT |
denotes |
the |
T50993 |
18032-18042 |
RB |
denotes |
previously |
T21233 |
18043-18052 |
VBN |
denotes |
published |
T39264 |
18053-18057 |
NN |
denotes |
SARS |
T63581 |
18058-18060 |
NN |
denotes |
2P |
T16458 |
18061-18070 |
NN |
denotes |
dataset52 |
T19972 |
18071-18074 |
VBD |
denotes |
was |
T72393 |
18075-18086 |
VBN |
denotes |
reprocessed |
T49131 |
18087-18090 |
IN |
denotes |
for |
T60843 |
18091-18095 |
DT |
denotes |
this |
T69625 |
18096-18101 |
NN |
denotes |
study |
T12832 |
18103-18111 |
IN |
denotes |
Although |
T24787 |
18112-18119 |
NN |
denotes |
cryo-EM |
T29672 |
18120-18128 |
NNS |
denotes |
datasets |
T9596 |
18129-18131 |
IN |
denotes |
of |
T45576 |
18132-18137 |
RB |
denotes |
fully |
T37894 |
18138-18150 |
VBN |
denotes |
glycosylated |
T35124 |
18151-18155 |
NNS |
denotes |
MERS |
T87593 |
18156-18159 |
NN |
denotes |
S41 |
T79382 |
18160-18163 |
CC |
denotes |
and |
T63281 |
18164-18174 |
NN |
denotes |
chimpanzee |
T35247 |
18175-18181 |
JJ |
denotes |
simian |
T82138 |
18182-18198 |
NN |
denotes |
immunodeficiency |
T35287 |
18199-18204 |
NN |
denotes |
virus |
T14224 |
18205-18206 |
-LRB- |
denotes |
( |
T81517 |
18206-18212 |
NN |
denotes |
SIVcpz |
T3442 |
18212-18213 |
-RRB- |
denotes |
) |
T14676 |
18213-18215 |
CD |
denotes |
53 |
T32530 |
18216-18219 |
VBP |
denotes |
are |
T45598 |
18220-18224 |
RB |
denotes |
also |
T95444 |
18225-18234 |
JJ |
denotes |
available |
T17171 |
18234-18235 |
-COMMA- |
denotes |
, |
T88916 |
18236-18240 |
RB |
denotes |
only |
T2700 |
18241-18244 |
DT |
denotes |
the |
T19064 |
18245-18248 |
NN |
denotes |
HIV |
T16401 |
18249-18252 |
CC |
denotes |
and |
T74879 |
18253-18257 |
NN |
denotes |
SARS |
T37597 |
18258-18262 |
NNS |
denotes |
data |
T46398 |
18263-18267 |
VBD |
denotes |
were |
T10901 |
18268-18270 |
IN |
denotes |
of |
T19935 |
18271-18281 |
JJ |
denotes |
sufficient |
T58744 |
18282-18289 |
NN |
denotes |
quality |
T47642 |
18290-18291 |
-LRB- |
denotes |
( |
T27616 |
18291-18297 |
CD |
denotes |
Fig. 5 |
T15042 |
18297-18298 |
-RRB- |
denotes |
) |
T64790 |
18300-18302 |
PRP |
denotes |
We |
T12200 |
18303-18311 |
RB |
denotes |
recently |
T55283 |
18312-18320 |
VBD |
denotes |
showed51 |
T5337 |
18321-18325 |
IN |
denotes |
that |
T85969 |
18326-18334 |
NNS |
denotes |
dynamics |
T15501 |
18335-18337 |
IN |
denotes |
in |
T81842 |
18338-18345 |
NN |
denotes |
surface |
T53947 |
18346-18353 |
VBN |
denotes |
exposed |
T58293 |
18354-18361 |
NNS |
denotes |
glycans |
T78469 |
18362-18367 |
NN |
denotes |
HIV-1 |
T11314 |
18368-18371 |
NN |
denotes |
Env |
T63261 |
18372-18377 |
VBZ |
denotes |
leads |
T50401 |
18378-18380 |
TO |
denotes |
to |
T72222 |
18381-18383 |
DT |
denotes |
an |
T69150 |
18384-18393 |
JJ |
denotes |
extensive |
T26975 |
18394-18401 |
NN |
denotes |
network |
T64977 |
18402-18404 |
IN |
denotes |
of |
T71776 |
18405-18417 |
NNS |
denotes |
interactions |
T7784 |
18418-18422 |
WDT |
denotes |
that |
T35226 |
18423-18428 |
VBP |
denotes |
drive |
T68570 |
18429-18441 |
JJR |
denotes |
higher-order |
T34602 |
18442-18453 |
NN |
denotes |
structuring |
T35212 |
18454-18456 |
IN |
denotes |
in |
T61552 |
18457-18460 |
DT |
denotes |
the |
T88226 |
18461-18467 |
NN |
denotes |
glycan |
T2686 |
18468-18474 |
NN |
denotes |
shield |
T70456 |
18476-18480 |
DT |
denotes |
This |
T49009 |
18481-18490 |
NN |
denotes |
structure |
T80667 |
18491-18498 |
VBZ |
denotes |
defines |
T33829 |
18499-18506 |
JJ |
denotes |
diffuse |
T1508 |
18507-18517 |
NNS |
denotes |
boundaries |
T66208 |
18518-18525 |
IN |
denotes |
between |
T95551 |
18526-18532 |
VBN |
denotes |
buried |
T27513 |
18533-18536 |
CC |
denotes |
and |
T63689 |
18537-18544 |
VBN |
denotes |
exposed |
T23712 |
18545-18552 |
NN |
denotes |
surface |
T90175 |
18553-18560 |
NN |
denotes |
protein |
T66804 |
18561-18568 |
NN |
denotes |
surface |
T71072 |
18568-18569 |
-COMMA- |
denotes |
, |
T80348 |
18570-18575 |
WDT |
denotes |
which |
T9316 |
18576-18579 |
MD |
denotes |
can |
T90504 |
18580-18585 |
VB |
denotes |
serve |
T42110 |
18586-18588 |
TO |
denotes |
to |
T69932 |
18589-18595 |
VB |
denotes |
define |
T67682 |
18596-18605 |
JJ |
denotes |
potential |
T2204 |
18606-18611 |
NNS |
denotes |
sites |
T70578 |
18612-18614 |
IN |
denotes |
of |
T95274 |
18615-18628 |
NN |
denotes |
vulnerability |
T46703 |
18630-18637 |
NN |
denotes |
Cryo-EM |
T30395 |
18638-18646 |
VBZ |
denotes |
captures |
T87072 |
18647-18650 |
DT |
denotes |
the |
T44958 |
18651-18667 |
JJ |
denotes |
ensemble-average |
T7879 |
18668-18677 |
NN |
denotes |
structure |
T75651 |
18678-18680 |
IN |
denotes |
of |
T66273 |
18681-18693 |
NNS |
denotes |
biomolecules |
T73691 |
18694-18697 |
CC |
denotes |
and |
T31109 |
18698-18707 |
RB |
denotes |
therefore |
T12255 |
18708-18714 |
NN |
denotes |
glycan |
T11220 |
18715-18723 |
NNS |
denotes |
dynamics |
T43250 |
18724-18731 |
VBZ |
denotes |
results |
T52169 |
18732-18734 |
IN |
denotes |
in |
T64021 |
18735-18742 |
VBN |
denotes |
blurred |
T49153 |
18743-18750 |
NN |
denotes |
density |
T2441 |
18751-18753 |
IN |
denotes |
at |
T80700 |
18754-18757 |
DT |
denotes |
the |
T16085 |
18758-18769 |
NNS |
denotes |
resolutions |
T86172 |
18770-18779 |
JJ |
denotes |
necessary |
T28589 |
18780-18783 |
IN |
denotes |
for |
T42839 |
18784-18792 |
VBG |
denotes |
building |
T3599 |
18793-18799 |
JJ |
denotes |
atomic |
T43748 |
18800-18809 |
NN |
denotes |
structure |
T10071 |
18811-18818 |
RB |
denotes |
However |
T88433 |
18818-18819 |
-COMMA- |
denotes |
, |
T97506 |
18820-18822 |
PRP |
denotes |
we |
T94206 |
18823-18829 |
VBD |
denotes |
showed |
T91691 |
18830-18833 |
WRB |
denotes |
how |
T17411 |
18834-18835 |
DT |
denotes |
a |
T2527 |
18836-18842 |
JJ |
denotes |
simple |
T82430 |
18843-18854 |
NN |
denotes |
combination |
T32469 |
18855-18857 |
IN |
denotes |
of |
T40028 |
18858-18866 |
JJ |
denotes |
low-pass |
T93291 |
18867-18876 |
NN |
denotes |
filtering |
T10413 |
18877-18880 |
CC |
denotes |
and |
T2487 |
18881-18898 |
NN |
denotes |
auto-thresholding |
T78379 |
18898-18899 |
-COMMA- |
denotes |
, |
T27010 |
18900-18902 |
RB |
denotes |
as |
T32044 |
18903-18907 |
RB |
denotes |
well |
T89162 |
18908-18910 |
IN |
denotes |
as |
T8187 |
18911-18913 |
NN |
denotes |
3D |
T99213 |
18914-18925 |
NN |
denotes |
variability |
T14190 |
18926-18934 |
NN |
denotes |
analysis |
T81037 |
18934-18935 |
-COMMA- |
denotes |
, |
T87732 |
18936-18939 |
MD |
denotes |
can |
T9264 |
18940-18946 |
VB |
denotes |
reveal |
T36472 |
18947-18950 |
DT |
denotes |
the |
T15866 |
18951-18961 |
RB |
denotes |
previously |
T33845 |
18962-18968 |
VBN |
denotes |
hidden |
T31709 |
18969-18978 |
NN |
denotes |
structure |
T97881 |
18979-18981 |
IN |
denotes |
of |
T77189 |
18982-18985 |
DT |
denotes |
the |
T22984 |
18986-18990 |
NNP |
denotes |
SARS |
T32877 |
18991-18997 |
NN |
denotes |
glycan |
T15037 |
18998-19004 |
NN |
denotes |
shield |
T70541 |
19005-19008 |
CC |
denotes |
and |
T30415 |
19009-19016 |
VB |
denotes |
compare |
T37461 |
19017-19019 |
PRP |
denotes |
it |
T52236 |
19020-19024 |
IN |
denotes |
with |
T25513 |
19025-19028 |
DT |
denotes |
the |
T63380 |
19029-19034 |
NN |
denotes |
HIV-1 |
T80636 |
19035-19038 |
NN |
denotes |
Env |
T69159 |
19039-19045 |
NN |
denotes |
glycan |
T3337 |
19046-19054 |
NN |
denotes |
shield51 |
T64033 |
19055-19056 |
-LRB- |
denotes |
( |
T94502 |
19056-19062 |
CD |
denotes |
Fig. 5 |
T94581 |
19062-19063 |
-RRB- |
denotes |
) |
T60289 |
19065-19067 |
PRP |
denotes |
We |
T75223 |
19068-19075 |
VBP |
denotes |
observe |
T57545 |
19076-19079 |
DT |
denotes |
the |
T48330 |
19080-19086 |
RB |
denotes |
nearly |
T87308 |
19087-19103 |
JJ |
denotes |
all-encompassing |
T1558 |
19104-19110 |
NN |
denotes |
glycan |
T99824 |
19111-19118 |
NN |
denotes |
density |
T59798 |
19119-19121 |
IN |
denotes |
on |
T56235 |
19122-19127 |
NN |
denotes |
HIV-1 |
T14383 |
19128-19131 |
NN |
denotes |
Env |
T33263 |
19132-19135 |
CC |
denotes |
and |
T4213 |
19136-19144 |
NN |
denotes |
evidence |
T91161 |
19145-19148 |
IN |
denotes |
for |
T79082 |
19149-19158 |
JJ |
denotes |
extensive |
T66189 |
19159-19172 |
NN |
denotes |
glycan–glycan |
T48593 |
19173-19185 |
NNS |
denotes |
interactions |
T42535 |
19185-19186 |
-COMMA- |
denotes |
, |
T14663 |
19187-19197 |
RB |
denotes |
especially |
T44869 |
19198-19200 |
IN |
denotes |
in |
T77065 |
19201-19204 |
DT |
denotes |
the |
T90752 |
19205-19217 |
NN |
denotes |
oligomannose |
T24864 |
19218-19223 |
NN |
denotes |
patch |
T20998 |
19224-19231 |
NNS |
denotes |
regions |
T55492 |
19231-19232 |
-COMMA- |
denotes |
, |
T69929 |
19233-19240 |
IN |
denotes |
whereas |
T90575 |
19241-19244 |
DT |
denotes |
the |
T59031 |
19245-19252 |
NNS |
denotes |
glycans |
T94235 |
19253-19255 |
IN |
denotes |
on |
T22232 |
19256-19260 |
NNP |
denotes |
SARS |
T7541 |
19261-19262 |
NNP |
denotes |
S |
T66013 |
19263-19269 |
VBP |
denotes |
appear |
T27090 |
19270-19274 |
RBR |
denotes |
more |
T7370 |
19275-19283 |
VBN |
denotes |
isolated |
T67487 |
19284-19287 |
CC |
denotes |
and |
T50530 |
19288-19292 |
VBP |
denotes |
lack |
T21892 |
19293-19296 |
DT |
denotes |
the |
T55852 |
19297-19309 |
JJ |
denotes |
wide-ranging |
T70160 |
19310-19316 |
NN |
denotes |
glycan |
T80844 |
19317-19325 |
NNS |
denotes |
networks |
T83936 |
19326-19330 |
WDT |
denotes |
that |
T81018 |
19331-19334 |
VBP |
denotes |
are |
T68036 |
19335-19338 |
DT |
denotes |
the |
T82951 |
19339-19347 |
NN |
denotes |
hallmark |
T16903 |
19348-19350 |
IN |
denotes |
of |
T2902 |
19351-19353 |
DT |
denotes |
an |
T18742 |
19354-19363 |
JJ |
denotes |
effective |
T88640 |
19364-19370 |
NN |
denotes |
glycan |
T57983 |
19371-19382 |
NN |
denotes |
shield54,55 |
T96638 |
19384-19387 |
DT |
denotes |
The |
T9355 |
19388-19390 |
NN |
denotes |
3D |
T47791 |
19391-19402 |
NN |
denotes |
variability |
T79677 |
19403-19407 |
NNS |
denotes |
maps |
T51290 |
19408-19411 |
VBP |
denotes |
are |
T66740 |
19412-19416 |
RBR |
denotes |
more |
T28675 |
19417-19426 |
JJ |
denotes |
sensitive |
T51626 |
19427-19429 |
TO |
denotes |
to |
T96563 |
19430-19433 |
JJ |
denotes |
low |
T5756 |
19434-19443 |
NN |
denotes |
intensity |
T42122 |
19444-19450 |
NN |
denotes |
signal |
T93380 |
19451-19454 |
CC |
denotes |
and |
T52275 |
19455-19461 |
VBP |
denotes |
reveal |
T65761 |
19462-19472 |
JJ |
denotes |
additional |
T40659 |
19473-19486 |
NN |
denotes |
glycan–glycan |
T18648 |
19487-19499 |
NNS |
denotes |
interactions |
T53697 |
19500-19502 |
IN |
denotes |
in |
T13379 |
19503-19507 |
DT |
denotes |
both |
T61777 |
19508-19512 |
NNS |
denotes |
maps |
T1991 |
19512-19513 |
-COMMA- |
denotes |
, |
T10706 |
19514-19521 |
RB |
denotes |
however |
T21547 |
19522-19525 |
DT |
denotes |
the |
T89902 |
19526-19528 |
NN |
denotes |
S1 |
T24397 |
19529-19545 |
JJ |
denotes |
receptor-binding |
T67026 |
19546-19553 |
NNS |
denotes |
domains |
T98351 |
19554-19556 |
IN |
denotes |
in |
T69700 |
19557-19560 |
DT |
denotes |
the |
T97210 |
19561-19565 |
NN |
denotes |
SARS |
T19203 |
19566-19573 |
NN |
denotes |
dataset |
T21495 |
19574-19578 |
VBD |
denotes |
were |
T3893 |
19579-19584 |
VBN |
denotes |
shown |
T33461 |
19585-19587 |
TO |
denotes |
to |
T68704 |
19588-19593 |
VB |
denotes |
exist |
T1970 |
19594-19596 |
IN |
denotes |
in |
T91066 |
19597-19601 |
CC |
denotes |
both |
T75781 |
19602-19604 |
RB |
denotes |
up |
T44006 |
19605-19608 |
CC |
denotes |
and |
T47879 |
19609-19613 |
IN |
denotes |
down |
T22009 |
19614-19629 |
NN |
denotes |
conformations52 |
T80149 |
19629-19630 |
-COMMA- |
denotes |
, |
T10724 |
19631-19638 |
VBG |
denotes |
leading |
T29355 |
19639-19641 |
TO |
denotes |
to |
T48291 |
19642-19646 |
JJ |
denotes |
poor |
T15651 |
19647-19657 |
NN |
denotes |
resolution |
T15044 |
19658-19661 |
CC |
denotes |
and |
T36313 |
19662-19673 |
JJ |
denotes |
significant |
T78120 |
19674-19688 |
NN |
denotes |
2D-variability |
T97054 |
19689-19694 |
WDT |
denotes |
which |
T80897 |
19695-19697 |
VBZ |
denotes |
is |
T73857 |
19698-19707 |
VBN |
denotes |
convolved |
T52453 |
19708-19712 |
IN |
denotes |
with |
T12417 |
19713-19716 |
DT |
denotes |
the |
T9415 |
19717-19728 |
NN |
denotes |
variability |
T91463 |
19729-19735 |
VBG |
denotes |
coming |
T37758 |
19736-19740 |
IN |
denotes |
from |
T69399 |
19741-19748 |
NNS |
denotes |
glycans |
T37469 |
19749-19752 |
CC |
denotes |
and |
T7534 |
19753-19759 |
VBZ |
denotes |
limits |
T29335 |
19760-19763 |
DT |
denotes |
the |
T16169 |
19764-19780 |
NN |
denotes |
interpretability |
T54909 |
19781-19783 |
IN |
denotes |
of |
T36751 |
19784-19790 |
NN |
denotes |
glycan |
T68517 |
19791-19800 |
NN |
denotes |
shielding |
T73688 |
19801-19808 |
NNS |
denotes |
effects |
T27520 |
19809-19811 |
IN |
denotes |
in |
T1634 |
19812-19816 |
DT |
denotes |
this |
T15004 |
19817-19823 |
NN |
denotes |
region |
T14842 |
19824-19826 |
IN |
denotes |
of |
T18381 |
19827-19830 |
DT |
denotes |
the |
T85741 |
19831-19834 |
NN |
denotes |
map |
T77710 |
19836-19840 |
NNP |
denotes |
Fig. |
T43639 |
19841-19842 |
CD |
denotes |
5 |
T80136 |
19843-19854 |
JJ |
denotes |
Comparative |
T57723 |
19855-19862 |
NN |
denotes |
cryo-EM |
T19047 |
19863-19871 |
NN |
denotes |
analysis |
T52944 |
19872-19874 |
IN |
denotes |
of |
T86979 |
19875-19879 |
NNP |
denotes |
SARS |
T71022 |
19880-19881 |
NNP |
denotes |
S |
T87387 |
19882-19885 |
CC |
denotes |
and |
T92374 |
19886-19891 |
NN |
denotes |
HIV-1 |
T58960 |
19892-19895 |
NN |
denotes |
Env |
T67673 |
19896-19902 |
NN |
denotes |
glycan |
T21302 |
19903-19910 |
NNS |
denotes |
shields |
T48820 |
19912-19913 |
DT |
denotes |
a |
T79466 |
19914-19918 |
NNP |
denotes |
Left |
T16113 |
19919-19924 |
NN |
denotes |
panel |
T98169 |
19924-19925 |
-COLON- |
denotes |
: |
T63629 |
19926-19935 |
VBN |
denotes |
Sharpened |
T90429 |
19936-19952 |
JJ |
denotes |
3.2-Å-resolution |
T6423 |
19953-19965 |
JJ |
denotes |
C3-symmetric |
T13124 |
19966-19973 |
NN |
denotes |
cryo-EM |
T56273 |
19974-19977 |
NN |
denotes |
map |
T86558 |
19978-19980 |
IN |
denotes |
of |
T37174 |
19981-19985 |
NNP |
denotes |
SARS |
T84496 |
19986-19987 |
NNP |
denotes |
S |
T86959 |
19988-19990 |
NN |
denotes |
2P |
T75209 |
19991-20003 |
NN |
denotes |
ectodomain52 |
T37067 |
20004-20014 |
VBN |
denotes |
visualized |
T22530 |
20015-20017 |
IN |
denotes |
at |
T60171 |
20018-20019 |
DT |
denotes |
a |
T27128 |
20020-20024 |
JJ |
denotes |
high |
T94740 |
20025-20032 |
NN |
denotes |
contour |
T58510 |
20033-20038 |
NN |
denotes |
level |
T66412 |
20039-20043 |
IN |
denotes |
with |
T32176 |
20044-20054 |
VBN |
denotes |
disordered |
T5395 |
20055-20057 |
NN |
denotes |
S1 |
T34000 |
20058-20074 |
JJ |
denotes |
receptor-binding |
T54890 |
20075-20078 |
CC |
denotes |
and |
T9018 |
20079-20089 |
JJ |
denotes |
N-terminal |
T68442 |
20090-20097 |
NNS |
denotes |
domains |
T72184 |
20098-20107 |
VBG |
denotes |
extending |
T12801 |
20108-20111 |
RP |
denotes |
out |
T26493 |
20112-20116 |
IN |
denotes |
from |
T4854 |
20117-20120 |
DT |
denotes |
the |
T35333 |
20121-20128 |
JJ |
denotes |
central |
T39891 |
20129-20133 |
NN |
denotes |
core |
T4786 |
20135-20141 |
JJ |
denotes |
Middle |
T40721 |
20142-20147 |
NN |
denotes |
panel |
T2753 |
20147-20148 |
-COLON- |
denotes |
: |
T68941 |
20149-20157 |
JJ |
denotes |
Low-pass |
T98545 |
20158-20166 |
VBN |
denotes |
filtered |
T5712 |
20167-20168 |
-LRB- |
denotes |
( |
T65635 |
20168-20171 |
NN |
denotes |
lpf |
T36825 |
20171-20172 |
-RRB- |
denotes |
) |
T66628 |
20173-20180 |
NN |
denotes |
cryo-EM |
T90188 |
20181-20184 |
NN |
denotes |
map |
T57750 |
20185-20187 |
IN |
denotes |
of |
T25808 |
20188-20191 |
DT |
denotes |
the |
T69826 |
20192-20204 |
NN |
denotes |
glycoprotein |
T87240 |
20205-20215 |
VBN |
denotes |
visualised |
T62278 |
20216-20218 |
IN |
denotes |
at |
T88612 |
20219-20220 |
DT |
denotes |
a |
T55069 |
20221-20224 |
JJ |
denotes |
low |
T38898 |
20225-20232 |
NN |
denotes |
contour |
T68027 |
20233-20238 |
NN |
denotes |
level |
T69920 |
20239-20244 |
IN |
denotes |
along |
T22579 |
20245-20249 |
IN |
denotes |
with |
T51416 |
20250-20251 |
DT |
denotes |
a |
T26917 |
20252-20261 |
JJ |
denotes |
simulated |
T72481 |
20262-20274 |
JJ |
denotes |
peptide-only |
T91266 |
20275-20278 |
NN |
denotes |
map |
T43073 |
20279-20287 |
NN |
denotes |
overlaid |
T20774 |
20289-20294 |
JJ |
denotes |
Right |
T74921 |
20295-20300 |
NN |
denotes |
panel |
T5294 |
20300-20301 |
-COLON- |
denotes |
: |
T27512 |
20302-20307 |
NN |
denotes |
SPARX |
T17578 |
20308-20310 |
NN |
denotes |
3D |
T69974 |
20311-20322 |
NN |
denotes |
variability |
T86316 |
20323-20329 |
NN |
denotes |
map51. |
T39562 |
20330-20331 |
NN |
denotes |
b |
T43304 |
20332-20336 |
JJ |
denotes |
Same |
T52255 |
20337-20339 |
IN |
denotes |
as |
T48004 |
20340-20342 |
IN |
denotes |
in |
T51718 |
20343-20344 |
-LRB- |
denotes |
( |
T36617 |
20344-20345 |
DT |
denotes |
a |
T97382 |
20345-20346 |
-RRB- |
denotes |
) |
T54597 |
20347-20350 |
CC |
denotes |
but |
T81241 |
20351-20354 |
IN |
denotes |
for |
T90782 |
20355-20360 |
NN |
denotes |
HIV-1 |
T13950 |
20361-20364 |
NNP |
denotes |
Env |
T55209 |
20365-20370 |
NN |
denotes |
BG505 |
T53941 |
20371-20380 |
NN |
denotes |
SOSIP.664 |
T83312 |
20381-20390 |
NN |
denotes |
construct |
T96415 |
20391-20393 |
IN |
denotes |
in |
T45843 |
20394-20401 |
NN |
denotes |
complex |
T56194 |
20402-20406 |
IN |
denotes |
with |
T46276 |
20407-20412 |
CD |
denotes |
three |
T95298 |
20413-20419 |
NNS |
denotes |
copies |
T19490 |
20420-20422 |
IN |
denotes |
of |
T71992 |
20423-20429 |
NN |
denotes |
RM20A3 |
T28802 |
20430-20443 |
JJ |
denotes |
base-specific |
T65942 |
20444-20450 |
NN |
denotes |
Fabs51 |
T27171 |
20453-20462 |
JJ |
denotes |
Disparate |
T82701 |
20463-20472 |
NN |
denotes |
shielding |
T84269 |
20473-20483 |
NNS |
denotes |
efficacies |
T39330 |
20484-20486 |
IN |
denotes |
of |
T82468 |
20487-20492 |
JJ |
denotes |
viral |
T81349 |
20493-20506 |
NN |
denotes |
glycosylation |
T55443 |
20507-20512 |
JJ |
denotes |
Viral |
T49065 |
20513-20521 |
NN |
denotes |
envelope |
T84653 |
20522-20530 |
NNS |
denotes |
proteins |
T43155 |
20531-20534 |
VBP |
denotes |
are |
T38543 |
20535-20547 |
VBN |
denotes |
glycosylated |
T78070 |
20548-20550 |
TO |
denotes |
to |
T10289 |
20551-20558 |
VBG |
denotes |
varying |
T40134 |
20559-20566 |
NNS |
denotes |
degrees |
T67415 |
20566-20567 |
-COMMA- |
denotes |
, |
T91973 |
20568-20571 |
CC |
denotes |
but |
T56277 |
20572-20581 |
VBG |
denotes |
depending |
T67259 |
20582-20584 |
IN |
denotes |
on |
T24257 |
20585-20590 |
PRP-DOLLAR- |
denotes |
their |
T41537 |
20591-20598 |
JJ |
denotes |
overall |
T90997 |
20599-20603 |
NN |
denotes |
mass |
T80023 |
20603-20604 |
-COMMA- |
denotes |
, |
T58957 |
20605-20612 |
NN |
denotes |
surface |
T24905 |
20613-20617 |
NN |
denotes |
area |
T39391 |
20617-20618 |
-COMMA- |
denotes |
, |
T28342 |
20619-20622 |
CC |
denotes |
and |
T95089 |
20623-20629 |
NN |
denotes |
volume |
T63529 |
20629-20630 |
-COMMA- |
denotes |
, |
T2361 |
20631-20634 |
DT |
denotes |
the |
T67520 |
20635-20642 |
JJ |
denotes |
overall |
T74143 |
20643-20650 |
NN |
denotes |
density |
T41564 |
20651-20653 |
IN |
denotes |
of |
T83144 |
20654-20660 |
NN |
denotes |
glycan |
T18180 |
20661-20670 |
NN |
denotes |
shielding |
T4164 |
20671-20674 |
MD |
denotes |
may |
T65417 |
20675-20681 |
VB |
denotes |
differ |
T71938 |
20682-20695 |
RB |
denotes |
significantly |
T57335 |
20697-20700 |
IN |
denotes |
For |
T68440 |
20701-20708 |
NN |
denotes |
example |
T98634 |
20708-20709 |
-COMMA- |
denotes |
, |
T80942 |
20710-20714 |
CC |
denotes |
both |
T39961 |
20715-20719 |
NN |
denotes |
LASV |
T61867 |
20720-20723 |
NN |
denotes |
GPC |
T97427 |
20724-20727 |
CC |
denotes |
and |
T69629 |
20728-20739 |
NN |
denotes |
coronavirus |
T13147 |
20740-20741 |
NN |
denotes |
S |
T76361 |
20742-20750 |
NNS |
denotes |
proteins |
T11359 |
20751-20758 |
VBP |
denotes |
consist |
T63374 |
20759-20761 |
IN |
denotes |
of |
T22368 |
20762-20764 |
CD |
denotes |
25 |
T83476 |
20764-20765 |
NN |
denotes |
% |
T86335 |
20766-20772 |
NN |
denotes |
glycan |
T7181 |
20773-20775 |
IN |
denotes |
by |
T64282 |
20776-20785 |
JJ |
denotes |
molecular |
T19690 |
20786-20792 |
NN |
denotes |
weight |
T82304 |
20794-20801 |
RB |
denotes |
However |
T18710 |
20801-20802 |
-COMMA- |
denotes |
, |
T92980 |
20803-20808 |
VBN |
denotes |
given |
T59451 |
20809-20812 |
DT |
denotes |
the |
T14852 |
20813-20826 |
RB |
denotes |
significantly |
T91376 |
20827-20833 |
JJR |
denotes |
larger |
T30498 |
20834-20841 |
NN |
denotes |
protein |
T87161 |
20842-20849 |
NN |
denotes |
surface |
T40590 |
20850-20854 |
NN |
denotes |
area |
T34685 |
20855-20858 |
CC |
denotes |
and |
T68729 |
20859-20865 |
NN |
denotes |
volume |
T30100 |
20866-20868 |
IN |
denotes |
of |
T69433 |
20869-20880 |
NN |
denotes |
coronavirus |
T57189 |
20881-20882 |
NN |
denotes |
S |
T90347 |
20883-20891 |
NNS |
denotes |
proteins |
T54950 |
20891-20892 |
-COMMA- |
denotes |
, |
T25542 |
20893-20901 |
NN |
denotes |
coverage |
T55713 |
20902-20904 |
IN |
denotes |
of |
T73077 |
20905-20908 |
DT |
denotes |
the |
T91248 |
20909-20915 |
NN |
denotes |
glycan |
T75525 |
20916-20924 |
NN |
denotes |
“shield” |
T85581 |
20925-20929 |
IN |
denotes |
over |
T10462 |
20930-20933 |
DT |
denotes |
the |
T38271 |
20934-20947 |
JJ |
denotes |
proteinaceous |
T15422 |
20948-20955 |
NN |
denotes |
surface |
T79412 |
20956-20958 |
VBZ |
denotes |
is |
T84846 |
20959-20971 |
RB |
denotes |
considerably |
T29000 |
20972-20979 |
JJR |
denotes |
sparser |
T67524 |
20980-20982 |
IN |
denotes |
in |
T19223 |
20983-20993 |
NN |
denotes |
comparison |
T56739 |
20994-20996 |
TO |
denotes |
to |
T26633 |
20997-21000 |
DT |
denotes |
the |
T50837 |
21001-21008 |
JJR |
denotes |
smaller |
T14862 |
21009-21013 |
NN |
denotes |
LASV |
T24662 |
21014-21017 |
NN |
denotes |
GPC |
T66930 |
21017-21018 |
-COMMA- |
denotes |
, |
T41800 |
21019-21024 |
WDT |
denotes |
which |
T43310 |
21025-21033 |
VBZ |
denotes |
occludes |
T12542 |
21034-21035 |
DT |
denotes |
a |
T78671 |
21036-21039 |
RB |
denotes |
far |
T97136 |
21040-21047 |
JJR |
denotes |
greater |
T85689 |
21048-21058 |
NN |
denotes |
proportion |
T37643 |
21059-21061 |
IN |
denotes |
of |
T83557 |
21062-21065 |
DT |
denotes |
the |
T32584 |
21066-21073 |
NN |
denotes |
protein |
T81297 |
21074-21081 |
NN |
denotes |
surface |
T57424 |
21082-21086 |
IN |
denotes |
with |
T34206 |
21087-21092 |
JJR |
denotes |
fewer |
T37921 |
21093-21100 |
NNS |
denotes |
glycans |
T28846 |
21102-21104 |
TO |
denotes |
To |
T62794 |
21105-21116 |
VB |
denotes |
demonstrate |
T60590 |
21117-21121 |
IN |
denotes |
that |
T13036 |
21122-21125 |
DT |
denotes |
the |
T83020 |
21126-21134 |
NN |
denotes |
presence |
T39523 |
21135-21137 |
IN |
denotes |
of |
T3739 |
21138-21151 |
NN |
denotes |
glycosylation |
T70902 |
21152-21157 |
VBZ |
denotes |
plays |
T36916 |
21158-21159 |
DT |
denotes |
a |
T54253 |
21160-21165 |
JJ |
denotes |
major |
T97319 |
21166-21170 |
NN |
denotes |
role |
T80278 |
21171-21173 |
IN |
denotes |
in |
T56668 |
21174-21177 |
DT |
denotes |
the |
T5602 |
21178-21184 |
JJ |
denotes |
immune |
T20048 |
21185-21193 |
NN |
denotes |
response |
T51090 |
21194-21196 |
TO |
denotes |
to |
T73801 |
21197-21202 |
DT |
denotes |
these |
T88581 |
21203-21212 |
JJ |
denotes |
different |
T72197 |
21213-21226 |
NNS |
denotes |
glycoproteins |
T95182 |
21226-21227 |
-COMMA- |
denotes |
, |
T91428 |
21228-21230 |
PRP |
denotes |
we |
T10009 |
21231-21238 |
VBD |
denotes |
studied |
T37828 |
21239-21242 |
DT |
denotes |
the |
T67976 |
21243-21250 |
NN |
denotes |
glycome |
T12260 |
21251-21253 |
IN |
denotes |
of |
T57382 |
21254-21261 |
JJ |
denotes |
several |
T97617 |
21262-21274 |
RB |
denotes |
biomedically |
T89645 |
21275-21284 |
JJ |
denotes |
important |
T8512 |
21285-21298 |
NNS |
denotes |
coronaviruses |
T62759 |
21299-21302 |
CC |
denotes |
and |
T88912 |
21303-21311 |
VBN |
denotes |
compared |
T64812 |
21312-21317 |
PRP-DOLLAR- |
denotes |
their |
T90729 |
21318-21324 |
NN |
denotes |
glycan |
T6629 |
21325-21337 |
NNS |
denotes |
compositions |
T15821 |
21338-21340 |
IN |
denotes |
in |
T75735 |
21341-21342 |
DT |
denotes |
a |
T68214 |
21343-21353 |
JJ |
denotes |
structural |
T93322 |
21354-21361 |
NN |
denotes |
context |
T77334 |
21363-21365 |
PRP |
denotes |
We |
T62822 |
21366-21370 |
RB |
denotes |
then |
T3264 |
21371-21383 |
VBD |
denotes |
investigated |
T90908 |
21384-21387 |
DT |
denotes |
the |
T93386 |
21388-21394 |
NN |
denotes |
glycan |
T20732 |
21395-21401 |
NN |
denotes |
shield |
T38777 |
21402-21411 |
NNS |
denotes |
densities |
T13008 |
21412-21414 |
IN |
denotes |
of |
T66872 |
21415-21420 |
CD |
denotes |
seven |
T69255 |
21421-21426 |
JJ |
denotes |
viral |
T47768 |
21427-21432 |
NN |
denotes |
class |
T56776 |
21433-21434 |
CD |
denotes |
I |
T4483 |
21435-21441 |
NN |
denotes |
fusion |
T51449 |
21442-21450 |
NNS |
denotes |
proteins |
T68472 |
21451-21456 |
VBG |
denotes |
using |
T54019 |
21457-21458 |
DT |
denotes |
a |
T34571 |
21459-21465 |
JJ |
denotes |
global |
T29179 |
21466-21476 |
JJ |
denotes |
structural |
T72666 |
21477-21485 |
NN |
denotes |
approach |
T29830 |
21486-21491 |
WDT |
denotes |
which |
T75361 |
21492-21495 |
VBD |
denotes |
was |
T60433 |
21496-21506 |
VBN |
denotes |
calculated |
T21150 |
21507-21509 |
IN |
denotes |
by |
T65408 |
21510-21518 |
VBG |
denotes |
dividing |
T12510 |
21519-21522 |
DT |
denotes |
the |
T47420 |
21523-21529 |
NN |
denotes |
number |
T7804 |
21530-21532 |
IN |
denotes |
of |
T96477 |
21533-21544 |
NNS |
denotes |
amino-acids |
T57287 |
21545-21549 |
WDT |
denotes |
that |
T31963 |
21550-21558 |
VBP |
denotes |
interact |
T11453 |
21559-21563 |
IN |
denotes |
with |
T5466 |
21564-21571 |
NNS |
denotes |
glycans |
T67617 |
21572-21574 |
IN |
denotes |
by |
T76751 |
21575-21578 |
DT |
denotes |
the |
T95787 |
21579-21585 |
NN |
denotes |
number |
T84433 |
21586-21588 |
IN |
denotes |
of |
T75342 |
21589-21607 |
JJ |
denotes |
solvent-accessible |
T8633 |
21608-21618 |
JJ |
denotes |
amino-acid |
T96165 |
21619-21627 |
NNS |
denotes |
residues |
T61859 |
21628-21630 |
IN |
denotes |
of |
T96398 |
21631-21635 |
DT |
denotes |
each |
T53031 |
21636-21646 |
JJ |
denotes |
respective |
T13646 |
21647-21659 |
NN |
denotes |
glycoprotein |
T34895 |
21660-21663 |
CC |
denotes |
and |
T21412 |
21664-21671 |
VBD |
denotes |
plotted |
T93327 |
21672-21676 |
DT |
denotes |
this |
T37324 |
21677-21684 |
IN |
denotes |
against |
T83132 |
21685-21697 |
NN |
denotes |
oligomannose |
T17751 |
21698-21707 |
NN |
denotes |
abundance |
T73372 |
21709-21710 |
DT |
denotes |
A |
T11561 |
21711-21717 |
JJ |
denotes |
strong |
T31010 |
21718-21729 |
NN |
denotes |
correlation |
T21278 |
21730-21733 |
VBD |
denotes |
was |
T95071 |
21734-21742 |
VBN |
denotes |
observed |
T30414 |
21743-21744 |
-LRB- |
denotes |
( |
T84041 |
21744-21750 |
NN |
denotes |
Fig. 6 |
T23375 |
21750-21751 |
-RRB- |
denotes |
) |
T37933 |
21752-21755 |
CC |
denotes |
and |
T54604 |
21756-21763 |
NNS |
denotes |
viruses |
T83021 |
21764-21776 |
RB |
denotes |
historically |
T67339 |
21777-21787 |
VBN |
denotes |
classified |
T1758 |
21788-21790 |
IN |
denotes |
as |
T50624 |
21791-21799 |
NN |
denotes |
“evasion |
T41175 |
21800-21809 |
NN |
denotes |
strong”56 |
T26594 |
21810-21813 |
VBD |
denotes |
had |
T17878 |
21814-21827 |
RB |
denotes |
significantly |
T59830 |
21828-21836 |
JJ |
denotes |
elevated |
T67014 |
21837-21843 |
NN |
denotes |
glycan |
T83252 |
21844-21850 |
NN |
denotes |
shield |
T44453 |
21851-21860 |
NNS |
denotes |
densities |
T12305 |
21861-21864 |
CC |
denotes |
and |
T84841 |
21865-21877 |
NN |
denotes |
oligomannose |
T65772 |
21878-21887 |
NN |
denotes |
abundance |
T36713 |
21887-21888 |
-COMMA- |
denotes |
, |
T36054 |
21889-21894 |
WDT |
denotes |
which |
T54589 |
21895-21906 |
VBZ |
denotes |
underscores |
T77386 |
21907-21910 |
DT |
denotes |
the |
T8708 |
21911-21921 |
NN |
denotes |
importance |
T99300 |
21922-21924 |
IN |
denotes |
of |
T3158 |
21925-21931 |
NN |
denotes |
glycan |
T44352 |
21932-21941 |
NN |
denotes |
shielding |
T8441 |
21942-21944 |
IN |
denotes |
in |
T91196 |
21945-21951 |
JJ |
denotes |
immune |
T54044 |
21952-21959 |
NN |
denotes |
evasion |
T60202 |
21961-21965 |
NNP |
denotes |
Fig. |
T35932 |
21966-21967 |
CD |
denotes |
6 |
T52424 |
21968-21978 |
NN |
denotes |
Comparison |
T33530 |
21979-21981 |
IN |
denotes |
of |
T64406 |
21982-21985 |
DT |
denotes |
the |
T54237 |
21986-21992 |
NN |
denotes |
glycan |
T17551 |
21993-22000 |
NNS |
denotes |
shields |
T16798 |
22001-22003 |
IN |
denotes |
of |
T41253 |
22004-22009 |
JJ |
denotes |
viral |
T25202 |
22010-22015 |
NN |
denotes |
class |
T14464 |
22016-22017 |
CD |
denotes |
I |
T85420 |
22018-22024 |
NN |
denotes |
fusion |
T28685 |
22025-22033 |
NNS |
denotes |
proteins |
T57548 |
22035-22041 |
NN |
denotes |
Glycan |
T11420 |
22042-22048 |
NN |
denotes |
shield |
T30294 |
22049-22058 |
NNS |
denotes |
densities |
T78773 |
22059-22063 |
VBD |
denotes |
were |
T51996 |
22064-22074 |
VBN |
denotes |
calculated |
T60493 |
22075-22080 |
VBG |
denotes |
using |
T24146 |
22081-22089 |
NNPS |
denotes |
Proteins |
T7451 |
22089-22090 |
-COMMA- |
denotes |
, |
T11968 |
22091-22101 |
NNP |
denotes |
Interfaces |
T93687 |
22101-22102 |
-COMMA- |
denotes |
, |
T97859 |
22103-22113 |
NNPS |
denotes |
Structures |
T31999 |
22114-22117 |
CC |
denotes |
and |
T70602 |
22118-22128 |
NNPS |
denotes |
Assemblies |
T67118 |
22129-22130 |
-LRB- |
denotes |
( |
T86788 |
22130-22134 |
NN |
denotes |
PISA |
T23666 |
22134-22135 |
-RRB- |
denotes |
) |
T93480 |
22135-22137 |
CD |
denotes |
83 |
T54925 |
22138-22146 |
NNS |
denotes |
analyses |
T13544 |
22147-22149 |
IN |
denotes |
of |
T10473 |
22150-22155 |
RB |
denotes |
fully |
T95681 |
22156-22168 |
VBN |
denotes |
glycosylated |
T46270 |
22169-22175 |
NNS |
denotes |
models |
T25318 |
22176-22178 |
IN |
denotes |
of |
T63214 |
22179-22183 |
NNP |
denotes |
SARS |
T36278 |
22184-22185 |
NNP |
denotes |
S |
T38160 |
22185-22186 |
-COMMA- |
denotes |
, |
T32901 |
22187-22191 |
NNP |
denotes |
MERS |
T50082 |
22192-22193 |
NNP |
denotes |
S |
T20315 |
22193-22194 |
-COMMA- |
denotes |
, |
T26336 |
22195-22199 |
NNP |
denotes |
HKU1 |
T80637 |
22200-22201 |
NNP |
denotes |
S |
T28124 |
22201-22202 |
-COMMA- |
denotes |
, |
T48490 |
22203-22207 |
NN |
denotes |
LASV |
T53169 |
22208-22211 |
NN |
denotes |
GPC |
T70489 |
22211-22212 |
-COMMA- |
denotes |
, |
T36851 |
22213-22218 |
NN |
denotes |
HIV-1 |
T61005 |
22219-22222 |
NN |
denotes |
Env |
T62312 |
22223-22224 |
-LRB- |
denotes |
( |
T36158 |
22224-22229 |
NN |
denotes |
BG505 |
T19207 |
22229-22230 |
-RRB- |
denotes |
) |
T1909 |
22230-22231 |
-COMMA- |
denotes |
, |
T16967 |
22232-22241 |
NN |
denotes |
Influenza |
T17288 |
22242-22246 |
NN |
denotes |
H3N2 |
T64807 |
22247-22260 |
NN |
denotes |
hemagglutinin |
T69427 |
22261-22262 |
-LRB- |
denotes |
( |
T33012 |
22262-22270 |
NNP |
denotes |
Victoria |
T31397 |
22271-22275 |
CD |
denotes |
2011 |
T95304 |
22275-22276 |
-RRB- |
denotes |
) |
T61501 |
22276-22277 |
-COMMA- |
denotes |
, |
T78843 |
22278-22281 |
NN |
denotes |
SIV |
T53051 |
22282-22285 |
NNP |
denotes |
Env |
T95730 |
22286-22287 |
-LRB- |
denotes |
( |
T35725 |
22287-22290 |
NN |
denotes |
PDB |
T46991 |
22291-22293 |
NN |
denotes |
ID |
T12133 |
22294-22298 |
NN |
denotes |
5X58 |
T34645 |
22298-22299 |
-COMMA- |
denotes |
, |
T32072 |
22300-22304 |
NN |
denotes |
5X59 |
T39600 |
22304-22305 |
-COMMA- |
denotes |
, |
T65590 |
22306-22310 |
NN |
denotes |
5I08 |
T19879 |
22310-22311 |
-COMMA- |
denotes |
, |
T61708 |
22312-22316 |
NN |
denotes |
5VK2 |
T80173 |
22316-22317 |
-COMMA- |
denotes |
, |
T86385 |
22318-22322 |
NN |
denotes |
4ZMJ |
T31925 |
22322-22323 |
-COMMA- |
denotes |
, |
T78881 |
22324-22328 |
NN |
denotes |
4O5N |
T64135 |
22328-22329 |
-COMMA- |
denotes |
, |
T30171 |
22330-22334 |
NN |
denotes |
6OHY |
T91114 |
22334-22335 |
-COMMA- |
denotes |
, |
T4958 |
22336-22348 |
RB |
denotes |
respectively |
T39966 |
22348-22349 |
-RRB- |
denotes |
) |
T89368 |
22349-22362 |
CD |
denotes |
9,11,53,84–86 |
T57630 |
22364-22376 |
NN |
denotes |
Oligomannose |
T21025 |
22377-22387 |
NNS |
denotes |
abundances |
T24463 |
22388-22390 |
IN |
denotes |
of |
T96910 |
22391-22396 |
JJ |
denotes |
viral |
T1932 |
22397-22410 |
NNS |
denotes |
glycoproteins |
T11498 |
22411-22415 |
VBD |
denotes |
were |
T36644 |
22416-22427 |
VBN |
denotes |
ascertained |
T73246 |
22428-22430 |
IN |
denotes |
by |
T1782 |
22431-22441 |
NN |
denotes |
HILIC-UPLC |
T3180 |
22442-22450 |
NN |
denotes |
analysis |
T62295 |
22451-22453 |
IN |
denotes |
of |
T78639 |
22454-22460 |
NN |
denotes |
PNGase |
T58794 |
22461-22462 |
NN |
denotes |
F |
T67409 |
22463-22471 |
VBN |
denotes |
released |
T15765 |
22472-22480 |
JJ |
denotes |
N-linked |
T33026 |
22481-22488 |
NNS |
denotes |
glycans |
T60951 |
22489-22493 |
WDT |
denotes |
that |
T45752 |
22494-22498 |
VBD |
denotes |
were |
T96739 |
22499-22512 |
RB |
denotes |
fluorescently |
T44762 |
22513-22521 |
VBN |
denotes |
labelled |
T97123 |
22522-22526 |
IN |
denotes |
with |
T94571 |
22527-22547 |
NN |
denotes |
procainamide24,45,53 |
T49839 |
22548-22549 |
-LRB- |
denotes |
( |
T5501 |
22549-22551 |
NN |
denotes |
SI |
T78348 |
22552-22558 |
NN |
denotes |
Fig. 5 |
T93024 |
22558-22559 |
-RRB- |
denotes |
) |
T81346 |
22561-22564 |
DT |
denotes |
The |
T66936 |
22565-22571 |
NN |
denotes |
number |
T36773 |
22572-22574 |
IN |
denotes |
of |
T76460 |
22575-22585 |
JJ |
denotes |
amino-acid |
T27945 |
22586-22594 |
NNS |
denotes |
residues |
T75621 |
22595-22606 |
VBG |
denotes |
interacting |
T84066 |
22607-22611 |
IN |
denotes |
with |
T20906 |
22612-22620 |
JJ |
denotes |
N-linked |
T54866 |
22621-22628 |
NNS |
denotes |
glycans |
T73735 |
22629-22632 |
VBD |
denotes |
was |
T12725 |
22633-22640 |
VBN |
denotes |
divided |
T71326 |
22641-22643 |
IN |
denotes |
by |
T33187 |
22644-22647 |
DT |
denotes |
the |
T90192 |
22648-22654 |
NN |
denotes |
number |
T62752 |
22655-22657 |
IN |
denotes |
of |
T61364 |
22658-22676 |
JJ |
denotes |
solvent-accessible |
T68346 |
22677-22687 |
JJ |
denotes |
amino-acid |
T61476 |
22688-22696 |
NNS |
denotes |
residues |
T43495 |
22697-22699 |
IN |
denotes |
of |
T46241 |
22700-22703 |
DT |
denotes |
the |
T24762 |
22704-22716 |
NN |
denotes |
glycoprotein |
T53426 |
22717-22719 |
IN |
denotes |
as |
T85566 |
22720-22721 |
DT |
denotes |
a |
T28528 |
22722-22729 |
NN |
denotes |
measure |
T60922 |
22730-22733 |
IN |
denotes |
for |
T57613 |
22734-22740 |
JJ |
denotes |
global |
T92947 |
22741-22747 |
NN |
denotes |
glycan |
T81164 |
22748-22754 |
NN |
denotes |
shield |
T10370 |
22755-22762 |
NN |
denotes |
density |
T61338 |
22764-22767 |
DT |
denotes |
All |
T48920 |
22768-22773 |
JJ |
denotes |
viral |
T68543 |
22774-22787 |
NNS |
denotes |
glycoproteins |
T82274 |
22788-22796 |
VBN |
denotes |
analysed |
T26853 |
22797-22801 |
VBD |
denotes |
were |
T71248 |
22802-22811 |
VBN |
denotes |
expressed |
T33142 |
22812-22814 |
IN |
denotes |
as |
T69877 |
22815-22822 |
NNS |
denotes |
trimers |
T70780 |
22823-22825 |
IN |
denotes |
in |
T61720 |
22826-22833 |
NN |
denotes |
HEK293F |
T11163 |
22834-22839 |
NNS |
denotes |
cells |
T6955 |
22840-22845 |
RB |
denotes |
apart |
T40144 |
22846-22850 |
IN |
denotes |
from |
T86025 |
22851-22855 |
NN |
denotes |
LASV |
T38606 |
22856-22859 |
NN |
denotes |
GPC |
T52914 |
22859-22860 |
-COMMA- |
denotes |
, |
T35666 |
22861-22866 |
WDT |
denotes |
which |
T47548 |
22867-22870 |
VBD |
denotes |
was |
T56105 |
22871-22878 |
VBN |
denotes |
derived |
T54764 |
22879-22883 |
IN |
denotes |
from |
T18669 |
22884-22894 |
JJ |
denotes |
virus-like |
T49812 |
22895-22904 |
NNS |
denotes |
particles |
T85286 |
22905-22909 |
IN |
denotes |
from |
T2491 |
22910-22921 |
JJ |
denotes |
Madin-Darby |
T81144 |
22922-22928 |
JJ |
denotes |
canine |
T79381 |
22929-22935 |
NN |
denotes |
kidney |
T4581 |
22936-22938 |
CD |
denotes |
II |
T55061 |
22939-22944 |
NNS |
denotes |
cells |
T77073 |
22946-22953 |
IN |
denotes |
Whether |
T67807 |
22954-22957 |
DT |
denotes |
the |
T93664 |
22958-22968 |
JJ |
denotes |
restricted |
T45320 |
22969-22975 |
NN |
denotes |
glycan |
T66354 |
22976-22985 |
NN |
denotes |
shielding |
T51052 |
22986-22994 |
VBN |
denotes |
observed |
T89745 |
22995-22997 |
IN |
denotes |
on |
T75541 |
22998-23011 |
NNS |
denotes |
coronaviruses |
T6297 |
23012-23014 |
VBZ |
denotes |
is |
T72680 |
23015-23021 |
VBN |
denotes |
linked |
T21071 |
23022-23024 |
TO |
denotes |
to |
T25999 |
23025-23028 |
DT |
denotes |
the |
T64543 |
23029-23037 |
NN |
denotes |
zoonosis |
T98572 |
23038-23040 |
IN |
denotes |
of |
T45232 |
23041-23044 |
DT |
denotes |
the |
T83454 |
23045-23054 |
NNS |
denotes |
pathogens |
T22467 |
23055-23057 |
VBZ |
denotes |
is |
T99216 |
23058-23065 |
JJ |
denotes |
unknown |
T96797 |
23067-23074 |
RB |
denotes |
However |
T9612 |
23074-23075 |
-COMMA- |
denotes |
, |
T50771 |
23076-23078 |
PRP |
denotes |
it |
T66305 |
23079-23081 |
VBZ |
denotes |
is |
T45372 |
23082-23090 |
VBG |
denotes |
tempting |
T20635 |
23091-23093 |
TO |
denotes |
to |
T10053 |
23094-23103 |
VB |
denotes |
speculate |
T71408 |
23103-23104 |
-COMMA- |
denotes |
, |
T41377 |
23105-23108 |
IN |
denotes |
for |
T63997 |
23109-23116 |
NN |
denotes |
example |
T55394 |
23116-23117 |
-COMMA- |
denotes |
, |
T32869 |
23118-23122 |
IN |
denotes |
that |
T14682 |
23123-23127 |
NNS |
denotes |
MERS |
T19094 |
23128-23131 |
VBZ |
denotes |
has |
T21668 |
23132-23135 |
RB |
denotes |
not |
T76353 |
23136-23143 |
VBN |
denotes |
evolved |
T45819 |
23144-23145 |
DT |
denotes |
a |
T85678 |
23146-23151 |
JJ |
denotes |
dense |
T77537 |
23152-23158 |
NN |
denotes |
shield |
T26368 |
23159-23164 |
IN |
denotes |
since |
T68778 |
23165-23167 |
PRP |
denotes |
it |
T46258 |
23168-23173 |
MD |
denotes |
would |
T84900 |
23174-23177 |
RB |
denotes |
not |
T11621 |
23178-23183 |
VB |
denotes |
offer |
T10630 |
23184-23186 |
RB |
denotes |
as |
T89313 |
23187-23191 |
JJ |
denotes |
much |
T61578 |
23192-23194 |
IN |
denotes |
of |
T35149 |
23195-23196 |
DT |
denotes |
a |
T47037 |
23197-23207 |
JJ |
denotes |
protective |
T11435 |
23208-23217 |
NN |
denotes |
advantage |
T31174 |
23218-23225 |
IN |
denotes |
against |
T44925 |
23226-23231 |
NN |
denotes |
camel |
T15627 |
23232-23242 |
NNS |
denotes |
nanobodies |
T39650 |
23243-23244 |
-LRB- |
denotes |
( |
T37112 |
23244-23248 |
RB |
denotes |
also |
T10045 |
23249-23254 |
VBN |
denotes |
known |
T88998 |
23255-23257 |
IN |
denotes |
as |
T18704 |
23258-23271 |
JJ |
denotes |
single-domain |
T56245 |
23272-23282 |
NNS |
denotes |
antibodies |
T77976 |
23282-23283 |
-RRB- |
denotes |
) |
T64574 |
23284-23289 |
WDT |
denotes |
which |
T32529 |
23290-23295 |
MD |
denotes |
could |
T62658 |
23296-23300 |
RBR |
denotes |
more |
T74010 |
23301-23307 |
RB |
denotes |
easily |
T43286 |
23308-23317 |
VB |
denotes |
penetrate |
T94995 |
23318-23320 |
PRP |
denotes |
it |
T58389 |
23322-23335 |
NN |
denotes |
Investigation |
T28787 |
23336-23338 |
IN |
denotes |
of |
T88817 |
23339-23342 |
DT |
denotes |
the |
T51212 |
23343-23347 |
NN |
denotes |
host |
T22448 |
23348-23354 |
JJ |
denotes |
immune |
T97014 |
23355-23363 |
NN |
denotes |
response |
T84588 |
23364-23366 |
TO |
denotes |
to |
T22349 |
23367-23374 |
NNS |
denotes |
viruses |
T85837 |
23375-23377 |
IN |
denotes |
in |
T29947 |
23378-23383 |
PRP-DOLLAR- |
denotes |
their |
T60633 |
23384-23391 |
JJ |
denotes |
natural |
T20023 |
23392-23402 |
NNS |
denotes |
reservoirs |
T98213 |
23403-23406 |
MD |
denotes |
may |
T89551 |
23407-23412 |
VB |
denotes |
offer |
T67690 |
23413-23414 |
DT |
denotes |
a |
T79346 |
23415-23420 |
NN |
denotes |
route |
T99997 |
23421-23423 |
TO |
denotes |
to |
T77964 |
23424-23437 |
VBG |
denotes |
understanding |
T72412 |
23438-23441 |
WRB |
denotes |
why |
T1666 |
23442-23453 |
NN |
denotes |
coronavirus |
T33538 |
23454-23467 |
NN |
denotes |
glycosylation |
T88529 |
23468-23472 |
VBZ |
denotes |
does |
T92394 |
23473-23476 |
RB |
denotes |
not |
T23766 |
23477-23482 |
VB |
denotes |
reach |
T96858 |
23483-23486 |
DT |
denotes |
the |
T3894 |
23487-23494 |
NN |
denotes |
density |
T52698 |
23495-23497 |
IN |
denotes |
of |
T42360 |
23498-23503 |
JJ |
denotes |
other |
T26744 |
23504-23511 |
NNS |
denotes |
viruses |
T99485 |
23512-23516 |
JJ |
denotes |
such |
T82055 |
23517-23519 |
IN |
denotes |
as |
T18913 |
23520-23525 |
NN |
denotes |
HIV-1 |
T64649 |
23527-23529 |
IN |
denotes |
In |
T2320 |
23530-23538 |
NN |
denotes |
addition |
T78686 |
23538-23539 |
-COMMA- |
denotes |
, |
T83984 |
23540-23542 |
PRP |
denotes |
it |
T27307 |
23543-23546 |
MD |
denotes |
may |
T34676 |
23547-23549 |
VB |
denotes |
be |
T94812 |
23550-23554 |
IN |
denotes |
that |
T62851 |
23555-23565 |
JJ |
denotes |
functional |
T59734 |
23566-23577 |
NNS |
denotes |
constraints |
T18450 |
23577-23578 |
-COMMA- |
denotes |
, |
T92297 |
23579-23583 |
JJ |
denotes |
such |
T82162 |
23584-23586 |
IN |
denotes |
as |
T65049 |
23587-23598 |
VBG |
denotes |
maintaining |
T73605 |
23599-23610 |
NN |
denotes |
flexibility |
T82163 |
23611-23613 |
IN |
denotes |
of |
T95489 |
23614-23617 |
DT |
denotes |
the |
T80363 |
23618-23634 |
JJ |
denotes |
receptor-binding |
T16712 |
23635-23642 |
NNS |
denotes |
domains |
T51721 |
23642-23643 |
-COMMA- |
denotes |
, |
T50969 |
23644-23649 |
VBP |
denotes |
limit |
T82950 |
23650-23653 |
DT |
denotes |
the |
T89747 |
23654-23663 |
NN |
denotes |
accretion |
T86415 |
23664-23666 |
IN |
denotes |
of |
T7969 |
23667-23674 |
NNS |
denotes |
glycans |
T9896 |
23675-23677 |
IN |
denotes |
on |
T98585 |
23678-23689 |
NN |
denotes |
coronavirus |
T75554 |
23690-23696 |
NNS |
denotes |
spikes |
T19065 |
23696-23697 |
-COMMA- |
denotes |
, |
T16194 |
23698-23703 |
WDT |
denotes |
which |
T68142 |
23704-23709 |
MD |
denotes |
would |
T16555 |
23710-23716 |
VB |
denotes |
render |
T87051 |
23717-23719 |
PRP |
denotes |
it |
T66339 |
23720-23729 |
JJ |
denotes |
incapable |
T85203 |
23730-23732 |
IN |
denotes |
of |
T82847 |
23733-23743 |
VBG |
denotes |
performing |
T94649 |
23744-23747 |
PRP-DOLLAR- |
denotes |
its |
T29264 |
23748-23755 |
JJ |
denotes |
primary |
T84155 |
23756-23765 |
NNS |
denotes |
functions |
T77249 |
23765-23766 |
-COMMA- |
denotes |
, |
T70958 |
23767-23776 |
VBG |
denotes |
including |
T87179 |
23777-23793 |
JJ |
denotes |
receptor-binding |
T16494 |
23794-23797 |
CC |
denotes |
and |
T62341 |
23798-23806 |
NN |
denotes |
membrane |
T47272 |
23807-23813 |
NN |
denotes |
fusion |
T74425 |
23815-23819 |
DT |
denotes |
This |
T28812 |
23820-23830 |
NN |
denotes |
phenomenon |
T23330 |
23831-23834 |
VBZ |
denotes |
has |
T79957 |
23835-23839 |
VBN |
denotes |
been |
T88747 |
23840-23848 |
VBN |
denotes |
observed |
T37978 |
23849-23851 |
IN |
denotes |
on |
T66756 |
23852-23857 |
JJ |
denotes |
other |
T49403 |
23858-23863 |
JJ |
denotes |
viral |
T71298 |
23864-23877 |
NNS |
denotes |
glycoproteins |
T42034 |
23877-23878 |
-COMMA- |
denotes |
, |
T50579 |
23879-23888 |
VBG |
denotes |
including |
T39729 |
23889-23898 |
NN |
denotes |
influenza |
T5616 |
23899-23902 |
NNS |
denotes |
HAs |
T5660 |
23902-23903 |
-COMMA- |
denotes |
, |
T25906 |
23904-23909 |
WRB |
denotes |
where |
T12419 |
23910-23915 |
EX |
denotes |
there |
T16685 |
23916-23918 |
VBZ |
denotes |
is |
T69838 |
23919-23920 |
DT |
denotes |
a |
T24412 |
23921-23926 |
NN |
denotes |
limit |
T2009 |
23927-23929 |
TO |
denotes |
to |
T53210 |
23930-23933 |
DT |
denotes |
the |
T7550 |
23934-23946 |
NN |
denotes |
accumulation |
T70799 |
23947-23949 |
IN |
denotes |
of |
T50138 |
23950-23963 |
NN |
denotes |
glycosylation |
T17645 |
23964-23969 |
NNS |
denotes |
sites |
T91429 |
23970-23974 |
WDT |
denotes |
that |
T69288 |
23975-23978 |
MD |
denotes |
can |
T77299 |
23979-23981 |
VB |
denotes |
be |
T39985 |
23982-23994 |
VBN |
denotes |
incorporated |
T22591 |
23995-23997 |
IN |
denotes |
in |
T39676 |
23998-24007 |
NN |
denotes |
vivo57,58 |
T98764 |
24007-24008 |
-COMMA- |
denotes |
, |
T66750 |
24009-24017 |
VBN |
denotes |
compared |
T34506 |
24018-24022 |
IN |
denotes |
with |
T30497 |
24023-24025 |
IN |
denotes |
in |
T49179 |
24026-24033 |
NN |
denotes |
vitro59 |
T8001 |
24033-24034 |
-COMMA- |
denotes |
, |
T19500 |
24035-24039 |
IN |
denotes |
with |
T55151 |
24040-24044 |
NN |
denotes |
H3N2 |
T55814 |
24045-24048 |
CC |
denotes |
and |
T64906 |
24049-24053 |
NN |
denotes |
H1N1 |
T93681 |
24054-24057 |
VBZ |
denotes |
HAs |
T72733 |
24058-24067 |
VBG |
denotes |
replacing |
T10927 |
24068-24076 |
VBG |
denotes |
existing |
T23904 |
24077-24081 |
NNS |
denotes |
PNGs |
T45261 |
24082-24088 |
RB |
denotes |
rather |
T77923 |
24089-24093 |
IN |
denotes |
than |
T40157 |
24094-24105 |
RB |
denotes |
continually |
T93082 |
24106-24112 |
VBG |
denotes |
adding |
T56943 |
24113-24117 |
PRP |
denotes |
them |
T51235 |
24118-24122 |
IN |
denotes |
upon |
T22651 |
24123-24126 |
DT |
denotes |
the |
T77822 |
24127-24144 |
NN |
denotes |
glycoprotein22,58 |
T55217 |
24146-24149 |
DT |
denotes |
The |
T19555 |
24150-24160 |
NN |
denotes |
importance |
T26714 |
24161-24163 |
IN |
denotes |
of |
T3445 |
24164-24177 |
NN |
denotes |
glycosylation |
T95262 |
24178-24180 |
IN |
denotes |
in |
T42577 |
24181-24191 |
NN |
denotes |
modulation |
T48803 |
24192-24194 |
IN |
denotes |
of |
T81500 |
24195-24200 |
JJ |
denotes |
viral |
T5930 |
24201-24212 |
NN |
denotes |
infectivity |
T8049 |
24213-24216 |
CC |
denotes |
and |
T70719 |
24217-24223 |
JJ |
denotes |
immune |
T49977 |
24224-24233 |
NNS |
denotes |
responses |
T93956 |
24234-24238 |
VBP |
denotes |
have |
T11993 |
24239-24243 |
RB |
denotes |
also |
T1601 |
24244-24248 |
VBN |
denotes |
been |
T74546 |
24249-24261 |
VBN |
denotes |
investigated |
T66965 |
24262-24268 |
IN |
denotes |
during |
T20256 |
24269-24278 |
NN |
denotes |
influenza |
T50741 |
24279-24286 |
NN |
denotes |
vaccine |
T54786 |
24287-24300 |
NN |
denotes |
research22,60 |
T60387 |
24301-24304 |
CC |
denotes |
and |
T65945 |
24305-24311 |
MD |
denotes |
should |
T90413 |
24312-24314 |
VB |
denotes |
be |
T59672 |
24315-24325 |
VBN |
denotes |
considered |
T67170 |
24326-24328 |
IN |
denotes |
in |
T43948 |
24329-24340 |
NN |
denotes |
coronavirus |
T96785 |
24341-24348 |
NN |
denotes |
vaccine |
T78856 |
24349-24357 |
NN |
denotes |
research |
T92680 |
24359-24363 |
RBR |
denotes |
More |
T84481 |
24364-24373 |
RB |
denotes |
topically |
T70792 |
24373-24374 |
-COMMA- |
denotes |
, |
T23248 |
24375-24377 |
PRP |
denotes |
it |
T53506 |
24378-24380 |
VBZ |
denotes |
is |
T18888 |
24381-24392 |
JJ |
denotes |
interesting |
T12601 |
24393-24395 |
TO |
denotes |
to |
T38716 |
24396-24400 |
VB |
denotes |
note |
T31921 |
24401-24404 |
DT |
denotes |
the |
T52475 |
24405-24417 |
NN |
denotes |
conservation |
T58850 |
24418-24420 |
IN |
denotes |
of |
T72458 |
24421-24429 |
JJ |
denotes |
N-linked |
T35369 |
24430-24443 |
NN |
denotes |
glycosylation |
T60774 |
24444-24449 |
NNS |
denotes |
sites |
T17084 |
24450-24452 |
IN |
denotes |
on |
T40757 |
24453-24454 |
NN |
denotes |
S |
T18965 |
24455-24463 |
NNS |
denotes |
proteins |
T72137 |
24464-24468 |
IN |
denotes |
from |
T71306 |
24469-24472 |
DT |
denotes |
the |
T25653 |
24473-24483 |
NN |
denotes |
SARS-CoV-2 |
T82634 |
24484-24487 |
CC |
denotes |
and |
T90138 |
24488-24492 |
NN |
denotes |
SARS |
T79086 |
24493-24494 |
-LRB- |
denotes |
( |
T21819 |
24494-24496 |
NN |
denotes |
SI |
T4098 |
24497-24503 |
NN |
denotes |
Fig. 6 |
T37852 |
24503-24504 |
-RRB- |
denotes |
) |
T34122 |
24506-24516 |
NN |
denotes |
SARS-CoV-2 |
T47078 |
24517-24526 |
VBZ |
denotes |
possesses |
T64573 |
24527-24528 |
DT |
denotes |
a |
T60437 |
24529-24534 |
NN |
denotes |
total |
T28667 |
24535-24537 |
IN |
denotes |
of |
T12092 |
24538-24540 |
CD |
denotes |
22 |
T1640 |
24541-24549 |
JJ |
denotes |
N-linked |
T97157 |
24550-24556 |
NN |
denotes |
glycan |
T11869 |
24557-24562 |
NNS |
denotes |
sites |
T81728 |
24563-24571 |
VBN |
denotes |
compared |
T53746 |
24572-24576 |
IN |
denotes |
with |
T64999 |
24577-24579 |
CD |
denotes |
23 |
T3044 |
24580-24582 |
IN |
denotes |
on |
T27983 |
24583-24587 |
NNP |
denotes |
SARS |
T70372 |
24587-24588 |
-COMMA- |
denotes |
, |
T36523 |
24589-24593 |
IN |
denotes |
with |
T81512 |
24594-24596 |
CD |
denotes |
18 |
T55641 |
24597-24599 |
IN |
denotes |
of |
T31809 |
24600-24605 |
DT |
denotes |
these |
T30346 |
24606-24611 |
NNS |
denotes |
sites |
T33229 |
24612-24617 |
VBG |
denotes |
being |
T95497 |
24618-24620 |
IN |
denotes |
in |
T81137 |
24621-24627 |
NN |
denotes |
common |
T99058 |
24629-24631 |
IN |
denotes |
As |
T67481 |
24632-24636 |
JJ |
denotes |
such |
T5512 |
24636-24637 |
-COMMA- |
denotes |
, |
T56317 |
24638-24640 |
PRP |
denotes |
it |
T83032 |
24641-24643 |
VBZ |
denotes |
is |
T6892 |
24644-24650 |
JJ |
denotes |
likely |
T46550 |
24651-24655 |
IN |
denotes |
that |
T32694 |
24656-24661 |
DT |
denotes |
these |
T45067 |
24662-24669 |
NNS |
denotes |
glycans |
T82922 |
24670-24672 |
IN |
denotes |
on |
T78450 |
24673-24677 |
DT |
denotes |
this |
T70467 |
24678-24683 |
JJ |
denotes |
novel |
T54943 |
24684-24695 |
NN |
denotes |
coronavirus |
T82041 |
24696-24701 |
MD |
denotes |
would |
T38496 |
24702-24708 |
VB |
denotes |
shield |
T40453 |
24709-24716 |
JJ |
denotes |
similar |
T78152 |
24717-24728 |
JJ |
denotes |
immunogenic |
T36034 |
24729-24737 |
NNS |
denotes |
epitopes |
T43430 |
24738-24742 |
WDT |
denotes |
that |
T42643 |
24743-24746 |
VBP |
denotes |
are |
T34663 |
24747-24755 |
VBN |
denotes |
observed |
T28338 |
24756-24758 |
IN |
denotes |
on |
T42537 |
24759-24763 |
NNP |
denotes |
SARS |
T28404 |
24764-24766 |
NNP |
denotes |
S. |
T34718 |
24767-24769 |
IN |
denotes |
As |
T3102 |
24770-24778 |
VBN |
denotes |
expected |
T14875 |
24778-24779 |
-COMMA- |
denotes |
, |
T72037 |
24780-24784 |
JJS |
denotes |
most |
T23602 |
24785-24787 |
IN |
denotes |
of |
T78209 |
24788-24791 |
DT |
denotes |
the |
T75405 |
24792-24803 |
NNS |
denotes |
differences |
T7434 |
24804-24811 |
IN |
denotes |
between |
T54679 |
24812-24815 |
DT |
denotes |
the |
T36690 |
24816-24819 |
CD |
denotes |
two |
T10541 |
24820-24827 |
NNS |
denotes |
viruses |
T22099 |
24828-24831 |
VBP |
denotes |
are |
T77577 |
24832-24840 |
VBN |
denotes |
observed |
T80845 |
24841-24843 |
IN |
denotes |
on |
T35913 |
24844-24847 |
DT |
denotes |
the |
T42862 |
24848-24850 |
NN |
denotes |
S1 |
T82481 |
24851-24858 |
NN |
denotes |
subunit |
T63639 |
24858-24859 |
-COMMA- |
denotes |
, |
T95917 |
24860-24863 |
JJ |
denotes |
due |
T19623 |
24864-24866 |
TO |
denotes |
to |
T39634 |
24867-24870 |
PRP-DOLLAR- |
denotes |
its |
T91852 |
24871-24882 |
NN |
denotes |
amenability |
T93743 |
24883-24885 |
TO |
denotes |
to |
T96851 |
24886-24899 |
NNS |
denotes |
substitutions |
T53841 |
24900-24905 |
IN |
denotes |
while |
T23506 |
24906-24911 |
RB |
denotes |
still |
T19959 |
24912-24921 |
VBG |
denotes |
remaining |
T60128 |
24922-24934 |
RB |
denotes |
functionally |
T58264 |
24935-24944 |
JJ |
denotes |
competent |
T45174 |
24946-24957 |
RB |
denotes |
Furthermore |
T77108 |
24957-24958 |
-COMMA- |
denotes |
, |
T23034 |
24959-24965 |
JJ |
denotes |
likely |
T28413 |
24966-24973 |
NNS |
denotes |
targets |
T16688 |
24974-24977 |
IN |
denotes |
for |
T51805 |
24978-24981 |
DT |
denotes |
the |
T98975 |
24982-24990 |
NN |
denotes |
majority |
T23520 |
24991-24993 |
IN |
denotes |
of |
T89744 |
24994-25004 |
NNS |
denotes |
antibodies |
T37340 |
25005-25014 |
VBG |
denotes |
targeting |
T85444 |
25015-25018 |
DT |
denotes |
the |
T12203 |
25019-25024 |
NN |
denotes |
spike |
T30887 |
25025-25028 |
VBP |
denotes |
are |
T9951 |
25029-25036 |
JJ |
denotes |
located |
T15001 |
25037-25039 |
IN |
denotes |
on |
T46529 |
25040-25042 |
NN |
denotes |
S1 |
T56103 |
25042-25043 |
-COMMA- |
denotes |
, |
T81494 |
25044-25053 |
VBG |
denotes |
resulting |
T44486 |
25054-25056 |
IN |
denotes |
in |
T32445 |
25057-25064 |
JJR |
denotes |
greater |
T72703 |
25065-25071 |
NNS |
denotes |
levels |
T40990 |
25072-25074 |
IN |
denotes |
of |
T38229 |
25075-25081 |
JJ |
denotes |
immune |
T43357 |
25082-25090 |
NN |
denotes |
pressure |
T59397 |
25091-25095 |
IN |
denotes |
upon |
T26191 |
25096-25100 |
DT |
denotes |
this |
T33036 |
25101-25108 |
NN |
denotes |
subunit |
T97000 |
25110-25114 |
DT |
denotes |
This |
T64538 |
25115-25121 |
NN |
denotes |
notion |
T59288 |
25122-25124 |
VBZ |
denotes |
is |
T47385 |
25125-25132 |
RBR |
denotes |
further |
T35201 |
25133-25142 |
VBN |
denotes |
reflected |
T72056 |
25143-25145 |
IN |
denotes |
in |
T18104 |
25146-25151 |
NNS |
denotes |
terms |
T34570 |
25152-25154 |
IN |
denotes |
of |
T18734 |
25155-25168 |
NN |
denotes |
glycosylation |
T57766 |
25168-25169 |
-COMMA- |
denotes |
, |
T66534 |
25170-25174 |
IN |
denotes |
with |
T36486 |
25175-25178 |
DT |
denotes |
all |
T71292 |
25179-25181 |
IN |
denotes |
of |
T8985 |
25182-25185 |
DT |
denotes |
the |
T61275 |
25186-25192 |
NN |
denotes |
glycan |
T2410 |
25193-25198 |
NNS |
denotes |
sites |
T35106 |
25199-25208 |
VBN |
denotes |
conserved |
T58672 |
25209-25211 |
IN |
denotes |
on |
T57713 |
25212-25215 |
DT |
denotes |
the |
T22974 |
25216-25218 |
NN |
denotes |
S2 |
T26472 |
25219-25226 |
NN |
denotes |
subunit |
T18939 |
25227-25234 |
IN |
denotes |
between |
T72173 |
25235-25239 |
NN |
denotes |
SARS |
T72299 |
25240-25243 |
CC |
denotes |
and |
T10006 |
25244-25254 |
NN |
denotes |
SARS-CoV-2 |
T58557 |
25254-25255 |
-COMMA- |
denotes |
, |
T83864 |
25256-25263 |
IN |
denotes |
whereas |
T99079 |
25264-25267 |
DT |
denotes |
the |
T3040 |
25268-25270 |
NN |
denotes |
S1 |
T2354 |
25271-25278 |
NN |
denotes |
subunit |
T23968 |
25279-25287 |
VBZ |
denotes |
exhibits |
T71933 |
25288-25294 |
NN |
denotes |
glycan |
T60903 |
25295-25299 |
NN |
denotes |
site |
T37762 |
25300-25309 |
NNS |
denotes |
additions |
T91373 |
25310-25313 |
CC |
denotes |
and |
T25121 |
25314-25323 |
NNS |
denotes |
deletions |
T22092 |
25324-25325 |
-LRB- |
denotes |
( |
T71875 |
25325-25327 |
NN |
denotes |
SI |
T23058 |
25328-25334 |
NN |
denotes |
Fig. 7 |
T18793 |
25334-25335 |
-RRB- |
denotes |
) |
T76427 |
25337-25350 |
JJ |
denotes |
Bioinformatic |
T77800 |
25351-25359 |
NN |
denotes |
analysis |
T78537 |
25360-25362 |
IN |
denotes |
of |
T86297 |
25363-25370 |
JJ |
denotes |
current |
T80371 |
25371-25381 |
NN |
denotes |
SARS-CoV-2 |
T13595 |
25382-25387 |
NN |
denotes |
spike |
T39941 |
25388-25393 |
NNS |
denotes |
genes |
T50763 |
25394-25395 |
-LRB- |
denotes |
( |
T65176 |
25395-25402 |
NN |
denotes |
n = 566 |
T2438 |
25403-25405 |
IN |
denotes |
as |
T93347 |
25406-25408 |
IN |
denotes |
of |
T69209 |
25409-25411 |
CD |
denotes |
17 |
T15871 |
25412-25417 |
NNP |
denotes |
March |
T73572 |
25418-25422 |
CD |
denotes |
2020 |
T57682 |
25422-25423 |
-RRB- |
denotes |
) |
T37387 |
25424-25428 |
IN |
denotes |
from |
T97769 |
25429-25441 |
NN |
denotes |
nextstrain61 |
T59510 |
25442-25443 |
-LRB- |
denotes |
( |
T27017 |
25443-25448 |
NNS |
denotes |
https |
T63488 |
25448-25449 |
-COLON- |
denotes |
: |
T93568 |
25449-25470 |
LS |
denotes |
//nextstrain.org/ncov |
T43920 |
25470-25471 |
-RRB- |
denotes |
) |
T64664 |
25472-25480 |
VBD |
denotes |
revealed |
T48510 |
25481-25484 |
JJ |
denotes |
low |
T63332 |
25485-25493 |
NN |
denotes |
sequence |
T32624 |
25494-25503 |
NN |
denotes |
diversity |
T57322 |
25504-25507 |
CC |
denotes |
and |
T27673 |
25508-25510 |
DT |
denotes |
no |
T84080 |
25511-25518 |
NNS |
denotes |
changes |
T83739 |
25519-25521 |
IN |
denotes |
in |
T16571 |
25522-25535 |
NN |
denotes |
glycosylation |
T12246 |
25536-25541 |
NNS |
denotes |
sites |
T58601 |
25542-25543 |
-LRB- |
denotes |
( |
T48372 |
25543-25545 |
NN |
denotes |
SI |
T90304 |
25546-25552 |
NN |
denotes |
Fig. 8 |
T71179 |
25552-25553 |
-RRB- |
denotes |
) |
T66481 |
25555-25563 |
IN |
denotes |
Although |
T38463 |
25564-25566 |
PRP |
denotes |
it |
T32700 |
25567-25569 |
VBZ |
denotes |
is |
T80633 |
25570-25579 |
JJ |
denotes |
difficult |
T73791 |
25580-25582 |
TO |
denotes |
to |
T38418 |
25583-25591 |
RB |
denotes |
directly |
T73114 |
25592-25599 |
VB |
denotes |
compare |
T86863 |
25600-25607 |
NNS |
denotes |
viruses |
T8410 |
25608-25610 |
IN |
denotes |
in |
T65868 |
25611-25616 |
NNS |
denotes |
terms |
T23843 |
25617-25619 |
IN |
denotes |
of |
T28466 |
25620-25631 |
JJ |
denotes |
immunogenic |
T17810 |
25632-25641 |
NNS |
denotes |
responses |
T36441 |
25641-25642 |
-COMMA- |
denotes |
, |
T29228 |
25643-25645 |
IN |
denotes |
on |
T30037 |
25646-25649 |
DT |
denotes |
the |
T26015 |
25650-25653 |
CD |
denotes |
one |
T67621 |
25654-25658 |
NN |
denotes |
hand |
T57010 |
25658-25659 |
-COMMA- |
denotes |
, |
T90266 |
25660-25664 |
NN |
denotes |
SARS |
T24380 |
25665-25668 |
CC |
denotes |
and |
T36665 |
25669-25673 |
NN |
denotes |
MERS |
T44450 |
25674-25687 |
NNS |
denotes |
coronaviruses |
T66786 |
25688-25695 |
RB |
denotes |
readily |
T32211 |
25696-25702 |
VBP |
denotes |
elicit |
T72375 |
25703-25715 |
VBG |
denotes |
neutralizing |
T20910 |
25716-25726 |
NNS |
denotes |
antibodies |
T2480 |
25727-25736 |
VBG |
denotes |
following |
T94939 |
25737-25746 |
NN |
denotes |
infection |
T86648 |
25747-25749 |
CC |
denotes |
or |
T76172 |
25750-25767 |
NN |
denotes |
immunization62–65 |
T55600 |
25769-25775 |
RB |
denotes |
Indeed |
T32116 |
25775-25776 |
-COMMA- |
denotes |
, |
T76597 |
25777-25781 |
JJ |
denotes |
many |
T32770 |
25782-25791 |
JJ |
denotes |
potential |
T12004 |
25792-25800 |
NN |
denotes |
MERS-CoV |
T73974 |
25801-25808 |
NN |
denotes |
vaccine |
T17681 |
25809-25819 |
NNS |
denotes |
candidates |
T49759 |
25820-25823 |
VBP |
denotes |
are |
T53332 |
25824-25828 |
JJ |
denotes |
able |
T55323 |
25829-25831 |
TO |
denotes |
to |
T15804 |
25832-25838 |
VB |
denotes |
elicit |
T39172 |
25839-25843 |
JJ |
denotes |
high |
T65162 |
25844-25850 |
NNS |
denotes |
titres |
T41593 |
25851-25853 |
IN |
denotes |
of |
T16400 |
25854-25859 |
NN |
denotes |
serum |
T48129 |
25860-25863 |
NN |
denotes |
IgG |
T52826 |
25864-25868 |
IN |
denotes |
upon |
T87524 |
25869-25881 |
NN |
denotes |
immunization |
T13436 |
25882-25885 |
CC |
denotes |
but |
T79396 |
25886-25890 |
VBP |
denotes |
fail |
T3099 |
25891-25893 |
TO |
denotes |
to |
T40686 |
25894-25901 |
VB |
denotes |
produce |
T65430 |
25902-25912 |
JJ |
denotes |
sufficient |
T95434 |
25913-25920 |
JJ |
denotes |
mucosal |
T85744 |
25921-25931 |
NN |
denotes |
immunity65 |
T60855 |
25933-25935 |
IN |
denotes |
In |
T15145 |
25936-25944 |
NN |
denotes |
contrast |
T83757 |
25944-25945 |
-COMMA- |
denotes |
, |
T41451 |
25946-25949 |
DT |
denotes |
the |
T95094 |
25950-25954 |
JJ |
denotes |
high |
T76290 |
25955-25963 |
NN |
denotes |
mutation |
T92271 |
25964-25970 |
NN |
denotes |
rate66 |
T59290 |
25971-25974 |
CC |
denotes |
and |
T46337 |
25975-25978 |
DT |
denotes |
the |
T52476 |
25979-25987 |
VBG |
denotes |
evolving |
T10675 |
25988-25994 |
NN |
denotes |
glycan |
T18714 |
25995-26001 |
NN |
denotes |
shield |
T37792 |
26002-26004 |
IN |
denotes |
of |
T21845 |
26005-26015 |
NN |
denotes |
HIV-120,39 |
T87196 |
26015-26016 |
-COMMA- |
denotes |
, |
T16269 |
26017-26022 |
WDT |
denotes |
which |
T23317 |
26023-26029 |
RB |
denotes |
firmly |
T90485 |
26030-26041 |
VBZ |
denotes |
exemplifies |
T49535 |
26042-26044 |
PRP |
denotes |
it |
T16896 |
26045-26047 |
IN |
denotes |
as |
T63209 |
26048-26056 |
NN |
denotes |
“evasion |
T42025 |
26057-26064 |
NN |
denotes |
strong” |
T63465 |
26065-26070 |
NN |
denotes |
virus |
T4468 |
26070-26071 |
-COMMA- |
denotes |
, |
T1830 |
26072-26079 |
VBZ |
denotes |
hinders |
T56636 |
26080-26083 |
DT |
denotes |
the |
T80263 |
26084-26095 |
NN |
denotes |
development |
T21297 |
26096-26098 |
IN |
denotes |
of |
T77941 |
26099-26106 |
RB |
denotes |
broadly |
T47145 |
26107-26119 |
VBG |
denotes |
neutralizing |
T48978 |
26120-26140 |
NNS |
denotes |
antibodies67.Viruses |
T78349 |
26141-26151 |
VBN |
denotes |
classified |
T84508 |
26152-26154 |
IN |
denotes |
as |
T99687 |
26155-26163 |
NN |
denotes |
“evasion |
T94485 |
26164-26176 |
NN |
denotes |
strong”26,56 |
T8371 |
26177-26180 |
MD |
denotes |
may |
T70765 |
26181-26185 |
RB |
denotes |
then |
T19557 |
26186-26192 |
VB |
denotes |
differ |
T68211 |
26193-26196 |
JJ |
denotes |
due |
T58964 |
26197-26199 |
TO |
denotes |
to |
T91845 |
26200-26206 |
JJ |
denotes |
varied |
T28724 |
26207-26217 |
NNS |
denotes |
efficacies |
T35775 |
26218-26220 |
IN |
denotes |
of |
T42494 |
26221-26228 |
NN |
denotes |
protein |
T48391 |
26229-26236 |
NN |
denotes |
surface |
T91764 |
26237-26246 |
NN |
denotes |
shielding |
T1369 |
26247-26249 |
IN |
denotes |
by |
T1370 |
26250-26257 |
NNS |
denotes |
glycans |
T1371 |
26259-26266 |
RB |
denotes |
Overall |
T1372 |
26266-26267 |
-COMMA- |
denotes |
, |
T1373 |
26268-26272 |
DT |
denotes |
this |
T1374 |
26273-26278 |
NN |
denotes |
study |
T1375 |
26279-26283 |
VBZ |
denotes |
adds |
T1376 |
26284-26291 |
JJ |
denotes |
further |
T1377 |
26292-26300 |
NN |
denotes |
evidence |
T1378 |
26301-26311 |
VBG |
denotes |
suggesting |
T1379 |
26312-26316 |
IN |
denotes |
that |
T1380 |
26317-26326 |
JJ |
denotes |
extensive |
T1381 |
26327-26335 |
JJ |
denotes |
N-linked |
T1382 |
26336-26342 |
NN |
denotes |
glycan |
T1383 |
26343-26356 |
NNS |
denotes |
modifications |
T1384 |
26357-26359 |
IN |
denotes |
of |
T47921 |
26360-26364 |
NNP |
denotes |
SARS |
T1386 |
26365-26368 |
CC |
denotes |
and |
T1387 |
26369-26373 |
NNP |
denotes |
MERS |
T1388 |
26374-26377 |
NN |
denotes |
CoV |
T1389 |
26378-26379 |
NN |
denotes |
S |
T1390 |
26380-26388 |
NNS |
denotes |
proteins |
T1391 |
26389-26391 |
VBP |
denotes |
do |
T1392 |
26392-26395 |
RB |
denotes |
not |
T1393 |
26396-26406 |
VB |
denotes |
constitute |
T1394 |
26407-26409 |
DT |
denotes |
an |
T1395 |
26410-26419 |
JJ |
denotes |
effective |
T1396 |
26420-26426 |
NN |
denotes |
shield |
T1397 |
26426-26427 |
-COMMA- |
denotes |
, |
T1398 |
26428-26430 |
IN |
denotes |
in |
T1399 |
26431-26441 |
NN |
denotes |
comparison |
T1400 |
26442-26444 |
TO |
denotes |
to |
T1401 |
26445-26451 |
NN |
denotes |
glycan |
T1402 |
26452-26459 |
NNS |
denotes |
shields |
T1403 |
26460-26462 |
IN |
denotes |
of |
T1404 |
26463-26470 |
JJ |
denotes |
certain |
T1405 |
26471-26476 |
JJ |
denotes |
other |
T1406 |
26477-26484 |
NNS |
denotes |
viruses |
T1407 |
26484-26485 |
-COMMA- |
denotes |
, |
T1408 |
26486-26491 |
WDT |
denotes |
which |
T1409 |
26492-26494 |
VBZ |
denotes |
is |
T1410 |
26495-26504 |
VBN |
denotes |
reflected |
T1411 |
26505-26507 |
IN |
denotes |
by |
T1412 |
26508-26511 |
DT |
denotes |
the |
T1413 |
26512-26519 |
JJ |
denotes |
overall |
T1414 |
26520-26529 |
NN |
denotes |
structure |
T1415 |
26529-26530 |
-COMMA- |
denotes |
, |
T1416 |
26531-26538 |
NN |
denotes |
density |
T1417 |
26539-26542 |
CC |
denotes |
and |
T1418 |
26543-26555 |
NN |
denotes |
oligomannose |
T1419 |
26556-26565 |
NN |
denotes |
abundance |
T1420 |
26566-26572 |
IN |
denotes |
across |
T1421 |
26573-26576 |
DT |
denotes |
the |
T1422 |
26577-26590 |
VBG |
denotes |
corresponding |
T1423 |
26591-26599 |
JJ |
denotes |
trimeric |
T1424 |
26600-26613 |
NNS |
denotes |
glycoproteins |
T1425 |
26615-26617 |
PRP |
denotes |
We |
T1426 |
26618-26622 |
RB |
denotes |
also |
T1427 |
26623-26634 |
VBP |
denotes |
demonstrate |
T1428 |
26635-26639 |
IN |
denotes |
that |
T1429 |
26640-26650 |
JJ |
denotes |
amino-acid |
T1430 |
26651-26666 |
NN |
denotes |
diversification |
T1431 |
26667-26673 |
RB |
denotes |
indeed |
T1432 |
26674-26680 |
VBZ |
denotes |
occurs |
T1433 |
26681-26683 |
IN |
denotes |
at |
T1434 |
26684-26692 |
NN |
denotes |
antibody |
T1435 |
26693-26703 |
JJ |
denotes |
accessible |
T1436 |
26704-26711 |
NNS |
denotes |
regions |
T1437 |
26712-26714 |
IN |
denotes |
on |
T1438 |
26715-26718 |
DT |
denotes |
the |
T1439 |
26719-26725 |
NN |
denotes |
trimer |
T1440 |
26725-26726 |
-COMMA- |
denotes |
, |
T1441 |
26727-26732 |
WDT |
denotes |
which |
T1442 |
26733-26741 |
VBZ |
denotes |
confirms |
T1443 |
26742-26746 |
IN |
denotes |
that |
T1444 |
26747-26754 |
NNS |
denotes |
glycans |
T1445 |
26755-26759 |
VBP |
denotes |
play |
T1446 |
26760-26761 |
DT |
denotes |
a |
T1447 |
26762-26766 |
NN |
denotes |
role |
T1448 |
26767-26769 |
IN |
denotes |
in |
T1449 |
26770-26779 |
VBG |
denotes |
occluding |
T1450 |
26780-26788 |
JJ |
denotes |
specific |
T1451 |
26789-26796 |
NNS |
denotes |
regions |
T1452 |
26797-26799 |
IN |
denotes |
if |
T1453 |
26800-26813 |
NN |
denotes |
vulnerability |
T1454 |
26814-26816 |
IN |
denotes |
on |
T1455 |
26817-26820 |
DT |
denotes |
the |
T1456 |
26821-26833 |
NN |
denotes |
glycoprotein |
T1457 |
26835-26846 |
RB |
denotes |
Furthermore |
T1458 |
26846-26847 |
-COMMA- |
denotes |
, |
T1459 |
26848-26859 |
NNS |
denotes |
comparisons |
T1460 |
26860-26867 |
IN |
denotes |
between |
T1461 |
26868-26874 |
NN |
denotes |
glycan |
T1462 |
26875-26882 |
NNS |
denotes |
shields |
T1463 |
26883-26887 |
IN |
denotes |
from |
T1464 |
26888-26889 |
DT |
denotes |
a |
T1465 |
26890-26896 |
NN |
denotes |
number |
T1466 |
26897-26899 |
IN |
denotes |
of |
T1467 |
26900-26907 |
NNS |
denotes |
viruses |
T1468 |
26908-26917 |
VBP |
denotes |
highlight |
T1469 |
26918-26921 |
DT |
denotes |
the |
T1470 |
26922-26932 |
NN |
denotes |
importance |
T1471 |
26933-26935 |
IN |
denotes |
of |
T1472 |
26936-26937 |
DT |
denotes |
a |
T1473 |
26938-26944 |
NN |
denotes |
glycan |
T1474 |
26945-26951 |
NN |
denotes |
shield |
T1475 |
26952-26954 |
IN |
denotes |
in |
T1476 |
26955-26961 |
JJ |
denotes |
immune |
T1477 |
26962-26969 |
NN |
denotes |
evasion |
T1478 |
26970-26973 |
CC |
denotes |
and |
T1479 |
26974-26980 |
VBP |
denotes |
reveal |
T1480 |
26981-26991 |
JJ |
denotes |
structural |
T1481 |
26992-27002 |
NNS |
denotes |
principles |
T1482 |
27003-27007 |
WDT |
denotes |
that |
T1483 |
27008-27014 |
VBP |
denotes |
govern |
T1484 |
27015-27028 |
NN |
denotes |
glycosylation |
T1485 |
27029-27035 |
NN |
denotes |
status |
T1486 |
27038-27045 |
NNS |
denotes |
Methods |
T1487 |
27047-27057 |
NN |
denotes |
Expression |
T1488 |
27058-27061 |
CC |
denotes |
and |
T1489 |
27062-27074 |
NN |
denotes |
purification |
T1490 |
27075-27077 |
IN |
denotes |
of |
T1491 |
27078-27089 |
NN |
denotes |
coronavirus |
T1492 |
27090-27095 |
NN |
denotes |
spike |
T1493 |
27096-27109 |
NNS |
denotes |
glycoproteins |
T66971 |
37158-37162 |
NN |
denotes |
Data |
T67419 |
37163-37175 |
NN |
denotes |
availability |
T70752 |
37176-37178 |
IN |
denotes |
In |
T71106 |
37179-37187 |
NN |
denotes |
addition |
T63370 |
37188-37190 |
TO |
denotes |
to |
T89915 |
37191-37194 |
DT |
denotes |
the |
T46654 |
37195-37199 |
NNS |
denotes |
data |
T2508 |
37200-37208 |
VBN |
denotes |
reported |
T43756 |
37209-37211 |
IN |
denotes |
in |
T19013 |
37212-37216 |
DT |
denotes |
this |
T82408 |
37217-37222 |
NN |
denotes |
paper |
T73339 |
37223-37226 |
CC |
denotes |
and |
T52603 |
37227-37239 |
VBG |
denotes |
accompanying |
T19668 |
37240-37253 |
JJ |
denotes |
supplementary |
T40164 |
37254-37263 |
NNS |
denotes |
materials |
T27038 |
37263-37264 |
-COMMA- |
denotes |
, |
T95449 |
37265-37268 |
DT |
denotes |
the |
T8482 |
37269-37272 |
JJ |
denotes |
raw |
T15279 |
37273-37277 |
NN |
denotes |
mass |
T35189 |
37278-37291 |
JJ |
denotes |
spectrometric |
T75003 |
37292-37296 |
NNS |
denotes |
data |
T7467 |
37297-37301 |
WDT |
denotes |
that |
T20416 |
37302-37309 |
VBP |
denotes |
support |
T13339 |
37310-37313 |
DT |
denotes |
the |
T49949 |
37314-37322 |
NNS |
denotes |
findings |
T66016 |
37323-37325 |
IN |
denotes |
of |
T83452 |
37326-37330 |
DT |
denotes |
this |
T2995 |
37331-37336 |
NN |
denotes |
study |
T5230 |
37337-37346 |
VBD |
denotes |
presented |
T19897 |
37347-37351 |
VBP |
denotes |
have |
T54231 |
37352-37356 |
VBN |
denotes |
been |
T82683 |
37357-37366 |
VBN |
denotes |
deposited |
T24919 |
37367-37369 |
IN |
denotes |
on |
T76351 |
37370-37373 |
DT |
denotes |
the |
T57712 |
37374-37381 |
NN |
denotes |
MassIVE |
T49302 |
37382-37388 |
NN |
denotes |
server |
T7289 |
37389-37390 |
-LRB- |
denotes |
( |
T2587 |
37390-37395 |
NNS |
denotes |
https |
T59257 |
37395-37396 |
-COLON- |
denotes |
: |
T44204 |
37396-37414 |
LS |
denotes |
//massive.ucsd.edu |
T16560 |
37414-37415 |
-RRB- |
denotes |
) |
T82222 |
37416-37420 |
IN |
denotes |
with |
T81145 |
37421-37424 |
DT |
denotes |
the |
T98164 |
37425-37434 |
NN |
denotes |
accession |
T24622 |
37435-37440 |
NNS |
denotes |
codes |
T65959 |
37441-37442 |
-LRB- |
denotes |
( |
T37271 |
37442-37454 |
NN |
denotes |
MSV000084993 |
T97993 |
37455-37458 |
IN |
denotes |
for |
T69927 |
37459-37472 |
NNS |
denotes |
glycopeptides |
T69025 |
37473-37481 |
NN |
denotes |
analysis |
T36917 |
37482-37483 |
-LRB- |
denotes |
[ |
T36213 |
37483-37498 |
CD |
denotes |
10.25345/C58T21 |
T18488 |
37498-37499 |
-RRB- |
denotes |
] |
T81770 |
37499-37500 |
-SEMICOLON- |
denotes |
; |
T9637 |
37501-37504 |
CC |
denotes |
and |
T58053 |
37505-37517 |
NN |
denotes |
MSV000085152 |
T33696 |
37518-37521 |
IN |
denotes |
for |
T24408 |
37522-37530 |
JJ |
denotes |
N-linked |
T92063 |
37531-37538 |
NNS |
denotes |
glycans |
T21392 |
37539-37540 |
-LRB- |
denotes |
[ |
T95590 |
37540-37555 |
CD |
denotes |
10.25345/C54705 |
T62134 |
37555-37556 |
-RRB- |
denotes |
] |
T32352 |
37556-37557 |
-RRB- |
denotes |
) |
T8007 |
37560-37564 |
NN |
denotes |
Code |
T30036 |
37565-37577 |
NN |
denotes |
availability |
T40836 |
37578-37581 |
DT |
denotes |
All |
T88896 |
37582-37586 |
NN |
denotes |
code |
T74809 |
37587-37589 |
VBZ |
denotes |
is |
T50409 |
37590-37599 |
JJ |
denotes |
available |
T70751 |
37600-37604 |
IN |
denotes |
upon |
T23908 |
37605-37612 |
NN |
denotes |
request |
T22396 |
37615-37624 |
VBG |
denotes |
Competing |
T12458 |
37625-37634 |
NNS |
denotes |
interests |
T99279 |
37635-37641 |
NNP |
denotes |
J.S.M. |
T92949 |
37642-37645 |
CC |
denotes |
and |
T90646 |
37646-37652 |
NNP |
denotes |
A.B.W. |
T44407 |
37653-37656 |
VBP |
denotes |
are |
T4923 |
37657-37666 |
NNS |
denotes |
inventors |
T38815 |
37667-37669 |
IN |
denotes |
on |
T47877 |
37670-37674 |
NNP |
denotes |
U.S. |
T24667 |
37675-37681 |
NN |
denotes |
patent |
T74721 |
37682-37693 |
NN |
denotes |
application |
T49061 |
37694-37696 |
UH |
denotes |
no |
T45704 |
37698-37708 |
CD |
denotes |
62/412,703 |
T31567 |
37709-37710 |
-LRB- |
denotes |
( |
T68265 |
37710-37720 |
NNP |
denotes |
“Prefusion |
T92957 |
37721-37732 |
NNP |
denotes |
Coronavirus |
T12321 |
37733-37738 |
NNP |
denotes |
Spike |
T56088 |
37739-37747 |
NNPS |
denotes |
Proteins |
T56201 |
37748-37751 |
CC |
denotes |
and |
T8618 |
37752-37757 |
PRP-DOLLAR- |
denotes |
Their |
T40602 |
37758-37762 |
NNP |
denotes |
Use” |
T54865 |
37762-37763 |
-RRB- |
denotes |
) |
T14376 |
37765-37771 |
NNP |
denotes |
J.S.M. |
T27441 |
37772-37774 |
VBZ |
denotes |
is |
T49283 |
37775-37777 |
DT |
denotes |
an |
T64497 |
37778-37786 |
NN |
denotes |
inventor |
T30321 |
37787-37789 |
IN |
denotes |
on |
T3983 |
37790-37794 |
NNP |
denotes |
U.S. |
T8998 |
37795-37801 |
NN |
denotes |
patent |
T9459 |
37802-37813 |
NN |
denotes |
application |
T17945 |
37814-37816 |
UH |
denotes |
no |
T18771 |
37818-37828 |
CD |
denotes |
62/972,886 |
T13320 |
37829-37830 |
-LRB- |
denotes |
( |
T27344 |
37830-37840 |
NN |
denotes |
“2019-nCoV |
T14035 |
37841-37849 |
NNP |
denotes |
Vaccine” |
T16970 |
37849-37850 |
-RRB- |
denotes |
) |
R0 |
T0 |
T1 |
arg1Of |
Vulnerabilities,in |
R1 |
T4 |
T1 |
arg2Of |
shields,in |
R10 |
T12 |
T13 |
arg1Of |
syndrome,( |
R100 |
T102 |
T103 |
arg1Of |
SARS,and |
R1000 |
T995 |
T994 |
arg1Of |
proteins,S |
R10009 |
T96165 |
T61859 |
arg1Of |
residues,of |
R1001 |
T1001 |
T996 |
arg1Of |
note,It |
R1002 |
T1001 |
T997 |
arg1Of |
note,is |
R1003 |
T999 |
T997 |
arg2Of |
interesting,is |
R1004 |
T997 |
T998 |
arg1Of |
is,also |
R1005 |
T1001 |
T999 |
arg1Of |
note,interesting |
R10051 |
T8494 |
T33083 |
arg3Of |
),( |
R1006 |
T1001 |
T1000 |
arg1Of |
note,to |
R10069 |
T44453 |
T12305 |
arg1Of |
densities,and |
R1007 |
T1008 |
T1001 |
arg2Of |
was,note |
R10078 |
T39465 |
T2313 |
arg1Of |
“shields”,glycan |
R1008 |
T1008 |
T1002 |
arg1Of |
was,that |
R1009 |
T1004 |
T1003 |
arg1Of |
distribution,the |
R101 |
T105 |
T103 |
arg2Of |
CoVs,and |
R1010 |
T1004 |
T1005 |
arg1Of |
distribution,of |
R1011 |
T1007 |
T1005 |
arg2Of |
glycans,of |
R1012 |
T1007 |
T1006 |
arg1Of |
glycans,oligomannose-type |
R1013 |
T1004 |
T1008 |
arg1Of |
distribution,was |
R1014 |
T1009 |
T1008 |
arg2Of |
broad,was |
R1015 |
T1004 |
T1009 |
arg1Of |
distribution,broad |
R10158 |
T31427 |
T9774 |
arg1Of |
proteins,recombinant |
R1016 |
T1017 |
T1009 |
arg2Of |
present,broad |
R1017 |
T1009 |
T1010 |
arg1Of |
broad,"," |
R1018 |
T1009 |
T1011 |
arg1Of |
broad,with |
R1019 |
T1012 |
T1011 |
arg2Of |
Man5GlcNAc2,with |
R10199 |
T42372 |
T61083 |
arg2Of |
S,and |
R102 |
T105 |
T104 |
arg1Of |
CoVs,HKU1 |
R1020 |
T1014 |
T1013 |
arg1Of |
Man9GlcNAc2,to |
R1021 |
T1015 |
T1014 |
arg2Of |
glycans,Man9GlcNAc2 |
R1022 |
T1017 |
T1016 |
arg1Of |
present,all |
R1023 |
T1014 |
T1017 |
arg1Of |
Man9GlcNAc2,present |
R1024 |
T1017 |
T1018 |
arg1Of |
present,"," |
R1025 |
T1017 |
T1019 |
arg1Of |
present,without |
R1026 |
T1023 |
T1019 |
arg2Of |
peak,without |
R1027 |
T1023 |
T1020 |
arg1Of |
peak,one |
R10275 |
T25653 |
T71306 |
arg1Of |
SARS-CoV-2,the |
R1028 |
T1023 |
T1021 |
arg1Of |
peak,particular |
R10287 |
T76130 |
T34257 |
arg1Of |
site,the |
R1029 |
T1023 |
T1022 |
arg1Of |
peak,dominant |
R103 |
T106 |
T107 |
arg1Of |
We,provide |
R1030 |
T1017 |
T1024 |
arg1Of |
present,"," |
R1031 |
T1017 |
T1025 |
arg1Of |
present,as |
R1032 |
T1026 |
T1025 |
arg2Of |
is,as |
R1033 |
T1028 |
T1026 |
arg1Of |
case,is |
R1034 |
T1028 |
T1027 |
arg1Of |
case,the |
R10349 |
T91445 |
T32785 |
arg1Of |
This,revealed |
R1035 |
T1028 |
T1029 |
arg1Of |
case,for |
R1036 |
T1032 |
T1029 |
arg2Of |
glycoproteins,for |
R10360 |
T80082 |
T50688 |
arg2Of |
glycopeptides,yield |
R10363 |
T84409 |
T7737 |
arg1Of |
site-specific,digested. Quantitative |
R1037 |
T1032 |
T1030 |
arg1Of |
glycoproteins,some |
R10375 |
T16458 |
T21233 |
arg1Of |
dataset52,published |
R1038 |
T1032 |
T1031 |
arg1Of |
glycoproteins,viral |
R1039 |
T1032 |
T1033 |
arg1Of |
glycoproteins,"," |
R104 |
T109 |
T107 |
arg2Of |
comparison,provide |
R1040 |
T1035 |
T1034 |
arg1Of |
as,such |
R10402 |
T65839 |
T58427 |
arg2Of |
and,to |
R1041 |
T1032 |
T1035 |
arg1Of |
glycoproteins,as |
R10411 |
T32200 |
T83554 |
arg1Of |
antibodies,"," |
R1042 |
T1037 |
T1035 |
arg2Of |
Env36,as |
R1043 |
T1037 |
T1036 |
arg1Of |
Env36,HIV-1 |
R1044 |
T1039 |
T1038 |
arg1Of |
proportion,The |
R1045 |
T1039 |
T1040 |
arg1Of |
proportion,of |
R1046 |
T1042 |
T1040 |
arg2Of |
glycans,of |
R10463 |
T77822 |
T22651 |
arg1Of |
"glycoprotein22,58",the |
R1047 |
T1042 |
T1041 |
arg1Of |
glycans,oligomannose-type |
R1048 |
T1039 |
T1043 |
arg1Of |
proportion,on |
R10483 |
T58379 |
T74716 |
arg2Of |
target,is |
R1049 |
T1047 |
T1043 |
arg2Of |
proteins,on |
R105 |
T109 |
T108 |
arg1Of |
comparison,a |
R1050 |
T1047 |
T1044 |
arg1Of |
proteins,recombinant |
R1051 |
T1047 |
T1045 |
arg1Of |
proteins,coronavirus |
R10516 |
T86793 |
T76095 |
arg1Of |
epitopes,"," |
R1052 |
T1047 |
T1046 |
arg1Of |
proteins,S |
R10524 |
T79807 |
T84889 |
arg1Of |
Fig. 3a,"," |
R1053 |
T1039 |
T1048 |
arg1Of |
proportion,is |
R10534 |
T95495 |
T2559 |
arg1Of |
grey,grey |
R1054 |
T1049 |
T1048 |
arg2Of |
consistent,is |
R1055 |
T1039 |
T1049 |
arg1Of |
proportion,consistent |
R1056 |
T1049 |
T1050 |
arg1Of |
consistent,with |
R1057 |
T1052 |
T1050 |
arg2Of |
studies,with |
R1058 |
T1052 |
T1051 |
arg1Of |
studies,previous |
R1059 |
T1052 |
T1053 |
arg2Of |
studies,performed |
R106 |
T109 |
T110 |
arg1Of |
comparison,of |
R1060 |
T1053 |
T1054 |
arg1Of |
performed,on |
R1061 |
T1058 |
T1054 |
arg2Of |
and,on |
R1062 |
T1056 |
T1055 |
arg1Of |
derived,virally |
R1063 |
T1057 |
T1056 |
arg1Of |
MERS,derived |
R10631 |
T71298 |
T50579 |
arg1Of |
glycoproteins,including |
R1064 |
T1057 |
T1058 |
arg1Of |
MERS,and |
R1065 |
T1062 |
T1058 |
arg2Of |
"proteins17,42",and |
R1066 |
T1062 |
T1059 |
arg1Of |
"proteins17,42",SARS |
R10660 |
T65942 |
T71992 |
arg1Of |
Fabs51,RM20A3 |
R1067 |
T1062 |
T1060 |
arg1Of |
"proteins17,42",coronavirus |
R10673 |
T19959 |
T23506 |
arg1Of |
remaining,still |
R1068 |
T1062 |
T1061 |
arg1Of |
"proteins17,42",S |
R1069 |
T1063 |
T1064 |
arg1Of |
Coronaviruses,have |
R107 |
T114 |
T110 |
arg2Of |
density,of |
R1070 |
T1068 |
T1064 |
arg2Of |
reported,have |
R10702 |
T10989 |
T93688 |
arg1Of |
"response21,31",adaptive |
R10709 |
T48593 |
T66189 |
arg1Of |
interactions,glycan–glycan |
R1071 |
T1063 |
T1065 |
arg1Of |
Coronaviruses,been |
R10719 |
T85689 |
T97136 |
arg1Of |
proportion,greater |
R1072 |
T1068 |
T1065 |
arg2Of |
reported,been |
R10724 |
T23904 |
T72733 |
arg2Of |
PNGs,replacing |
R1073 |
T1068 |
T1066 |
arg1Of |
reported,previously |
R1074 |
T1063 |
T1067 |
arg1Of |
Coronaviruses,been |
R10741 |
T39562 |
T86316 |
arg1Of |
b,map51. |
R1075 |
T1068 |
T1067 |
arg2Of |
reported,been |
R1076 |
T1063 |
T1068 |
arg2Of |
Coronaviruses,reported |
R1077 |
T1070 |
T1068 |
arg3Of |
form,reported |
R1078 |
T1070 |
T1069 |
arg1Of |
form,to |
R10787 |
T40354 |
T8442 |
arg1Of |
found,on |
R1079 |
T1063 |
T1070 |
arg1Of |
Coronaviruses,form |
R10796 |
T73292 |
T25939 |
arg1Of |
analysis,revealed |
R108 |
T114 |
T111 |
arg1Of |
density,the |
R1080 |
T1071 |
T1070 |
arg2Of |
virions,form |
R10800 |
T24412 |
T16685 |
arg2Of |
limit,is |
R1081 |
T1070 |
T1072 |
arg1Of |
form,by |
R1082 |
T1073 |
T1072 |
arg2Of |
budding,by |
R1083 |
T1063 |
T1073 |
arg1Of |
Coronaviruses,budding |
R1084 |
T1073 |
T1074 |
arg1Of |
budding,into |
R1085 |
T1076 |
T1074 |
arg2Of |
lumen,into |
R1086 |
T1076 |
T1075 |
arg1Of |
lumen,the |
R1087 |
T1076 |
T1077 |
arg1Of |
lumen,of |
R1088 |
T1081 |
T1077 |
arg2Of |
compartments,of |
R1089 |
T1081 |
T1078 |
arg1Of |
compartments,endoplasmic |
R10896 |
T84155 |
T94649 |
arg1Of |
functions,its |
R109 |
T114 |
T112 |
arg1Of |
density,global |
R1090 |
T1081 |
T1079 |
arg1Of |
compartments,reticulum-Golgi |
R1091 |
T1081 |
T1080 |
arg1Of |
compartments,intermediate |
R1092 |
T1081 |
T1082 |
arg1Of |
compartments,( |
R1093 |
T1083 |
T1082 |
arg2Of |
ERGIC,( |
R1094 |
T1084 |
T1082 |
arg3Of |
),( |
R10946 |
T3262 |
T93400 |
arg1Of |
glycoproteins,N-linked |
R1095 |
T1081 |
T1085 |
arg1Of |
compartments,"43,44" |
R10954 |
T40602 |
T8618 |
arg1Of |
Use”,Their |
R1096 |
T1086 |
T1087 |
arg1Of |
Observations,of |
R1097 |
T1089 |
T1087 |
arg2Of |
and,of |
R1098 |
T1088 |
T1089 |
arg1Of |
hybrid-,and |
R10980 |
T36665 |
T24380 |
arg2Of |
MERS,and |
R10984 |
T99216 |
T22467 |
arg2Of |
unknown,is |
R10987 |
T18955 |
T13208 |
arg1Of |
Asn155,"," |
R1099 |
T1091 |
T1089 |
arg2Of |
glycans,and |
R11 |
T14 |
T13 |
arg2Of |
SARS,( |
R110 |
T114 |
T113 |
arg1Of |
density,glycan |
R1100 |
T1091 |
T1090 |
arg1Of |
glycans,complex-type |
R1101 |
T1089 |
T1092 |
arg1Of |
and,on |
R1102 |
T1095 |
T1092 |
arg2Of |
"material17,42",on |
R11020 |
T74525 |
T72420 |
arg1Of |
but,Interestingly |
R1103 |
T1094 |
T1093 |
arg1Of |
derived,virally |
R1104 |
T1095 |
T1094 |
arg1Of |
"material17,42",derived |
R1105 |
T1086 |
T1096 |
arg1Of |
Observations,would |
R1106 |
T1100 |
T1099 |
arg2Of |
suggest,"," |
R1107 |
T1086 |
T1100 |
arg1Of |
Observations,suggest |
R1108 |
T1103 |
T1100 |
arg2Of |
is,suggest |
R1109 |
T1103 |
T1101 |
arg1Of |
is,that |
R11093 |
T10324 |
T18378 |
arg2Of |
ratios,( |
R111 |
T114 |
T115 |
arg1Of |
density,of |
R1110 |
T1102 |
T1103 |
arg1Of |
it,is |
R1111 |
T1104 |
T1103 |
arg2Of |
likely,is |
R11117 |
T58864 |
T16213 |
arg1Of |
diversity,amino-acid |
R1112 |
T1102 |
T1104 |
arg1Of |
it,likely |
R1113 |
T1108 |
T1104 |
arg2Of |
travel,likely |
R1114 |
T1108 |
T1105 |
arg1Of |
travel,that |
R11142 |
T31427 |
T12013 |
arg1Of |
proteins,HKU1 |
R1115 |
T1107 |
T1106 |
arg1Of |
virions,coronavirus |
R1116 |
T1107 |
T1108 |
arg1Of |
virions,travel |
R1117 |
T1108 |
T1109 |
arg1Of |
travel,through |
R1118 |
T1112 |
T1109 |
arg2Of |
apparatus,through |
R11187 |
T15627 |
T39650 |
arg1Of |
nanobodies,( |
R1119 |
T1112 |
T1110 |
arg1Of |
apparatus,the |
R112 |
T117 |
T115 |
arg2Of |
spikes,of |
R1120 |
T1112 |
T1111 |
arg1Of |
apparatus,Golgi |
R1121 |
T1112 |
T1113 |
arg1Of |
apparatus,after |
R1122 |
T1115 |
T1113 |
arg2Of |
formation,after |
R1123 |
T1115 |
T1114 |
arg1Of |
formation,virion |
R11238 |
T83973 |
T22042 |
arg2Of |
residues,buried |
R1124 |
T1115 |
T1116 |
arg1Of |
formation,in |
R1125 |
T1118 |
T1116 |
arg2Of |
ERGIC,in |
R1126 |
T1118 |
T1117 |
arg1Of |
ERGIC,the |
R1127 |
T1118 |
T1119 |
arg1Of |
ERGIC,en |
R1128 |
T1120 |
T1119 |
arg2Of |
route,en |
R1129 |
T1118 |
T1121 |
arg1Of |
ERGIC,to |
R11295 |
T55170 |
T96574 |
arg1Of |
inhibition,protein-directed |
R113 |
T117 |
T116 |
arg1Of |
spikes,coronavirus |
R1130 |
T1124 |
T1121 |
arg2Of |
surface,to |
R1131 |
T1124 |
T1122 |
arg1Of |
surface,the |
R1132 |
T1124 |
T1123 |
arg1Of |
surface,cell |
R1133 |
T1103 |
T1125 |
arg1Of |
is,"," |
R1134 |
T1127 |
T1126 |
arg1Of |
supporting,thus |
R1135 |
T1102 |
T1127 |
arg1Of |
it,supporting |
R1136 |
T1129 |
T1127 |
arg2Of |
immunogens,supporting |
R1137 |
T1103 |
T1127 |
modOf |
is,supporting |
R1138 |
T1129 |
T1128 |
arg1Of |
immunogens,recombinant |
R1139 |
T1127 |
T1130 |
arg1Of |
supporting,as |
R114 |
T109 |
T118 |
arg1Of |
comparison,with |
R1140 |
T1131 |
T1130 |
arg2Of |
models,as |
R1141 |
T1131 |
T1132 |
arg1Of |
models,of |
R1142 |
T1134 |
T1132 |
arg2Of |
glycoproteins,of |
R1143 |
T1134 |
T1133 |
arg1Of |
glycoproteins,viral |
R11432 |
T85948 |
T18466 |
arg1Of |
perturbing,greatly |
R1144 |
T1138 |
T1135 |
arg1Of |
analysis,Fig. |
R11447 |
T28741 |
T38149 |
arg2Of |
mapping,of |
R1145 |
T1135 |
T1136 |
arg1Of |
Fig.,1 |
R1146 |
T1138 |
T1137 |
arg1Of |
analysis,Compositional |
R11468 |
T43288 |
T96310 |
arg2Of |
resides,exposed |
R1147 |
T1138 |
T1139 |
arg1Of |
analysis,of |
R1148 |
T1140 |
T1139 |
arg2Of |
SARS,of |
R1149 |
T1140 |
T1141 |
arg1Of |
SARS,"," |
R115 |
T121 |
T118 |
arg2Of |
proteins,with |
R1150 |
T1143 |
T1141 |
arg2Of |
and,"," |
R1151 |
T1142 |
T1143 |
arg1Of |
MERS,and |
R11512 |
T21366 |
T99446 |
arg1Of |
sites,glycosylation |
R1152 |
T1145 |
T1143 |
arg2Of |
glycans,and |
R11527 |
T66745 |
T45284 |
arg1Of |
trimer,revealing |
R1153 |
T1145 |
T1144 |
arg1Of |
glycans,HKU1 |
R1154 |
T1148 |
T1146 |
arg1Of |
representation,a |
R1155 |
T1148 |
T1147 |
arg1Of |
representation,Schematic |
R11557 |
T39985 |
T22591 |
arg1Of |
incorporated,in |
R1156 |
T1148 |
T1149 |
arg1Of |
representation,of |
R11568 |
T86788 |
T67118 |
arg2Of |
PISA,( |
R1157 |
T1153 |
T1149 |
arg2Of |
and,of |
R11577 |
T59031 |
T94235 |
arg1Of |
glycans,on |
R1158 |
T1150 |
T1151 |
arg1Of |
SARS,"," |
R1159 |
T1152 |
T1151 |
arg2Of |
MERS,"," |
R116 |
T121 |
T119 |
arg1Of |
proteins,other |
R1160 |
T1151 |
T1153 |
arg1Of |
",",and |
R11603 |
T97319 |
T70902 |
arg2Of |
role,plays |
R1161 |
T1157 |
T1153 |
arg2Of |
glycoproteins,and |
R1162 |
T1157 |
T1154 |
arg1Of |
glycoproteins,HKU1 |
R1163 |
T1157 |
T1155 |
arg1Of |
glycoproteins,coronavirus |
R1164 |
T1157 |
T1156 |
arg1Of |
glycoproteins,S |
R1165 |
T1148 |
T1158 |
arg1Of |
representation,"," |
R1166 |
T1148 |
T1159 |
arg1Of |
representation,showing |
R1167 |
T1161 |
T1159 |
arg2Of |
positions,showing |
R1168 |
T1161 |
T1160 |
arg1Of |
positions,the |
R11685 |
T45704 |
T31567 |
arg1Of |
"62/412,703",( |
R1169 |
T1161 |
T1162 |
arg1Of |
positions,of |
R117 |
T121 |
T120 |
arg1Of |
proteins,viral |
R1170 |
T1166 |
T1162 |
arg2Of |
sequons,of |
R1171 |
T1166 |
T1163 |
arg1Of |
sequons,N-linked |
R11713 |
T36034 |
T40453 |
arg1Of |
epitopes,similar |
R1172 |
T1166 |
T1164 |
arg1Of |
sequons,glycosylation |
R1173 |
T1166 |
T1165 |
arg1Of |
sequons,amino-acid |
R1174 |
T1166 |
T1167 |
arg1Of |
sequons,( |
R1175 |
T1168 |
T1167 |
arg2Of |
NXS/T,( |
R1176 |
T1172 |
T1167 |
arg3Of |
),( |
R1177 |
T1168 |
T1169 |
arg1Of |
NXS/T,"," |
R11772 |
T11314 |
T78469 |
arg1Of |
Env,HIV-1 |
R1178 |
T1171 |
T1170 |
arg1Of |
X ≠ P,where |
R11789 |
T31709 |
T15866 |
arg1Of |
structure,previously |
R1179 |
T1168 |
T1171 |
arg1Of |
NXS/T,X ≠ P |
R118 |
T121 |
T122 |
arg1Of |
proteins,including |
R1180 |
T1166 |
T1173 |
arg2Of |
sequons,shown |
R1181 |
T1173 |
T1174 |
arg1Of |
shown,as |
R11819 |
T2354 |
T23968 |
arg1Of |
subunit,exhibits |
R1182 |
T1175 |
T1174 |
arg2Of |
branches,as |
R1183 |
T1178 |
T1177 |
arg1Of |
glycans,Oligomannose-type |
R11834 |
T12931 |
T18889 |
arg1Of |
Env,HIV-1 |
R1184 |
T1178 |
T1179 |
arg1Of |
glycans,are |
R1185 |
T1181 |
T1179 |
arg2Of |
annotated,are |
R1186 |
T1181 |
T1180 |
arg1Of |
annotated,schematically |
R11867 |
T76353 |
T19094 |
arg2Of |
evolved,has |
R1187 |
T1178 |
T1181 |
arg2Of |
glycans,annotated |
R1188 |
T1181 |
T1182 |
arg1Of |
annotated,with |
R11883 |
T17810 |
T28466 |
arg1Of |
responses,immunogenic |
R1189 |
T1184 |
T1182 |
arg2Of |
residues,with |
R119 |
T131 |
T122 |
arg2Of |
and,including |
R1190 |
T1184 |
T1183 |
arg1Of |
residues,mannose |
R11906 |
T36034 |
T34663 |
arg2Of |
epitopes,observed |
R1191 |
T1181 |
T1185 |
arg1Of |
annotated,as |
R1192 |
T1188 |
T1185 |
arg2Of |
and,as |
R1193 |
T1187 |
T1186 |
arg1Of |
circles,green |
R1194 |
T1187 |
T1188 |
arg1Of |
circles,and |
R1195 |
T1190 |
T1188 |
arg2Of |
residues,and |
R1196 |
T1190 |
T1189 |
arg1Of |
residues,GlcNAc |
R1197 |
T1181 |
T1191 |
arg1Of |
annotated,as |
R1198 |
T1193 |
T1191 |
arg2Of |
squares,as |
R1199 |
T1193 |
T1192 |
arg1Of |
squares,blue |
R12 |
T15 |
T13 |
arg3Of |
),( |
R120 |
T124 |
T123 |
arg1Of |
envelope,HIV-1 |
R1200 |
T1195 |
T1194 |
arg1Of |
ascertain,To |
R1201 |
T1211 |
T1194 |
modOf |
analysed,To |
R12013 |
T67339 |
T1758 |
arg1Of |
classified,as |
R1202 |
T1198 |
T1195 |
arg2Of |
structures,ascertain |
R1203 |
T1198 |
T1196 |
arg1Of |
structures,the |
R1204 |
T1198 |
T1197 |
arg1Of |
structures,precise |
R1205 |
T1198 |
T1199 |
arg1Of |
structures,of |
R1206 |
T1201 |
T1199 |
arg2Of |
glycans,of |
R12065 |
T66354 |
T93664 |
arg1Of |
shielding,restricted |
R1207 |
T1201 |
T1200 |
arg1Of |
glycans,N-linked |
R1208 |
T1211 |
T1202 |
arg1Of |
analysed,"," |
R1209 |
T1204 |
T1203 |
arg1Of |
pools,glycan |
R121 |
T124 |
T125 |
arg1Of |
envelope,"," |
R1210 |
T1204 |
T1205 |
arg1Of |
pools,of |
R12104 |
T25939 |
T88293 |
arg1Of |
revealed,when |
R1211 |
T1209 |
T1205 |
arg2Of |
protein,of |
R1212 |
T1209 |
T1206 |
arg1Of |
protein,each |
R12128 |
T74143 |
T41564 |
arg1Of |
density,of |
R1213 |
T1209 |
T1207 |
arg1Of |
protein,coronavirus |
R1214 |
T1209 |
T1208 |
arg1Of |
protein,S |
R1215 |
T1204 |
T1210 |
arg1Of |
pools,were |
R12152 |
T81512 |
T95497 |
arg1Of |
18,in |
R1216 |
T1211 |
T1210 |
arg2Of |
analysed,were |
R12169 |
T10378 |
T46370 |
arg1Of |
recognise,as |
R1217 |
T1217 |
T1211 |
arg1Of |
spectrometry,analysed |
R1218 |
T1204 |
T1211 |
arg2Of |
pools,analysed |
R12180 |
T43119 |
T79243 |
arg1Of |
SARS,and |
R1219 |
T1217 |
T1212 |
arg2Of |
spectrometry,by |
R122 |
T129 |
T125 |
arg2Of |
complex,"," |
R1220 |
T1217 |
T1213 |
arg1Of |
spectrometry,negative-ion |
R12204 |
T50082 |
T38160 |
arg2Of |
S,"," |
R1221 |
T1217 |
T1214 |
arg1Of |
spectrometry,ion-mobility-electrospray |
R1222 |
T1217 |
T1215 |
arg1Of |
spectrometry,ionisation |
R1223 |
T1217 |
T1216 |
arg1Of |
spectrometry,mass |
R1224 |
T1217 |
T1218 |
arg1Of |
spectrometry,( |
R1225 |
T1220 |
T1218 |
arg2Of |
MS,( |
R1226 |
T1221 |
T1218 |
arg3Of |
),( |
R1227 |
T1220 |
T1219 |
arg1Of |
MS,IM-ESI |
R1228 |
T1217 |
T1222 |
arg1Of |
spectrometry,( |
R12287 |
T20304 |
T68204 |
arg3Of |
differences,measured |
R1229 |
T1224 |
T1222 |
arg2Of |
Fig. 1,( |
R123 |
T129 |
T126 |
arg1Of |
complex,Lassa |
R1230 |
T1225 |
T1222 |
arg3Of |
),( |
R1231 |
T1224 |
T1223 |
arg1Of |
Fig. 1,Supplementary |
R1232 |
T1234 |
T1226 |
arg1Of |
confirmed,Consistent |
R1233 |
T1226 |
T1227 |
arg1Of |
Consistent,with |
R1234 |
T1230 |
T1227 |
arg2Of |
data,with |
R1235 |
T1230 |
T1228 |
arg1Of |
data,the |
R1236 |
T1230 |
T1229 |
arg1Of |
data,UPLC |
R12367 |
T54008 |
T35302 |
arg1Of |
diversity,was |
R1237 |
T1234 |
T1231 |
arg1Of |
confirmed,"," |
R1238 |
T1233 |
T1232 |
arg1Of |
MS,IM-ESI |
R1239 |
T1233 |
T1234 |
arg1Of |
MS,confirmed |
R124 |
T129 |
T127 |
arg1Of |
complex,virus |
R1240 |
T1236 |
T1234 |
arg2Of |
array,confirmed |
R1241 |
T1236 |
T1235 |
arg1Of |
array,an |
R1242 |
T1236 |
T1237 |
arg1Of |
array,of |
R12423 |
T59031 |
T66013 |
arg1Of |
glycans,appear |
R12427 |
T85689 |
T37643 |
arg1Of |
proportion,of |
R12429 |
T65828 |
T55016 |
arg2Of |
residues,with |
R1243 |
T1239 |
T1237 |
arg2Of |
glycans,of |
R1244 |
T1239 |
T1238 |
arg1Of |
glycans,complex-type |
R1245 |
T1239 |
T1240 |
arg1Of |
glycans,ranging |
R1246 |
T1240 |
T1241 |
arg1Of |
ranging,from |
R1247 |
T1242 |
T1241 |
arg2Of |
mono-,from |
R12478 |
T71022 |
T86979 |
arg1Of |
S,SARS |
R1248 |
T1242 |
T1243 |
arg1Of |
mono-,to |
R1249 |
T1246 |
T1243 |
arg2Of |
but,to |
R12493 |
T52754 |
T85424 |
arg1Of |
MERS,trimeric |
R12499 |
T75554 |
T9896 |
arg2Of |
spikes,on |
R125 |
T129 |
T128 |
arg1Of |
complex,glycoprotein |
R1250 |
T1246 |
T1245 |
arg1Of |
but,"," |
R12507 |
T25884 |
T85913 |
arg1Of |
values,are |
R1251 |
T1244 |
T1246 |
arg1Of |
tetra-antennary,but |
R1252 |
T1249 |
T1246 |
arg2Of |
and,but |
R1253 |
T1246 |
T1247 |
arg1Of |
but,also |
R1254 |
T1248 |
T1249 |
arg1Of |
oligomannose-,and |
R1255 |
T1251 |
T1249 |
arg2Of |
glycans,and |
R12558 |
T8069 |
T4310 |
arg1Of |
glycan28,substrate |
R1256 |
T1251 |
T1250 |
arg1Of |
glycans,hybrid-type |
R1257 |
T1254 |
T1252 |
arg1Of |
compositions,The |
R12577 |
T66354 |
T45320 |
arg1Of |
shielding,glycan |
R1258 |
T1254 |
T1253 |
arg1Of |
compositions,glycan |
R1259 |
T1254 |
T1255 |
arg2Of |
compositions,characterised |
R12595 |
T28784 |
T70607 |
arg1Of |
5X59,ID |
R126 |
T131 |
T130 |
arg1Of |
and,"," |
R1260 |
T1255 |
T1256 |
arg1Of |
characterised,in |
R1261 |
T1258 |
T1256 |
arg2Of |
spectra,in |
R1262 |
T1258 |
T1257 |
arg1Of |
spectra,the |
R12623 |
T82162 |
T92297 |
arg1Of |
as,such |
R1263 |
T1254 |
T1259 |
arg1Of |
compositions,were |
R1264 |
T1261 |
T1259 |
arg2Of |
invariant,were |
R1265 |
T1261 |
T1260 |
arg1Of |
invariant,largely |
R1266 |
T1254 |
T1261 |
arg1Of |
compositions,invariant |
R12669 |
T39921 |
T46370 |
arg2Of |
patterns,as |
R1267 |
T1261 |
T1262 |
arg1Of |
invariant,among |
R12670 |
T39503 |
T73192 |
arg1Of |
this,result |
R1268 |
T1264 |
T1262 |
arg2Of |
coronaviruses,among |
R12683 |
T55061 |
T2491 |
arg1Of |
cells,Madin-Darby |
R1269 |
T1264 |
T1263 |
arg1Of |
coronaviruses,the |
R127 |
T125 |
T131 |
arg1Of |
",",and |
R1270 |
T1264 |
T1265 |
arg1Of |
coronaviruses,with |
R1271 |
T1269 |
T1265 |
arg2Of |
differences,with |
R1272 |
T1269 |
T1266 |
arg1Of |
differences,no |
R1273 |
T1269 |
T1267 |
arg1Of |
differences,major |
R1274 |
T1269 |
T1268 |
arg1Of |
differences,structural |
R1275 |
T1269 |
T1270 |
arg2Of |
differences,observed |
R1276 |
T1271 |
T1272 |
arg1Of |
Clustering,of |
R1277 |
T1274 |
T1272 |
arg2Of |
glycans,of |
R1278 |
T1274 |
T1273 |
arg1Of |
glycans,underprocessed |
R12788 |
T97859 |
T93687 |
arg2Of |
Structures,"," |
R1279 |
T1271 |
T1275 |
arg1Of |
Clustering,on |
R128 |
T133 |
T131 |
arg2Of |
hemagglutinin,and |
R1280 |
T1277 |
T1275 |
arg2Of |
S,on |
R1281 |
T1277 |
T1276 |
arg1Of |
S,MERS |
R1282 |
T25019 |
T14782 |
arg2Of |
camels,from |
R1283 |
T25019 |
T86652 |
arg1Of |
camels,into |
R1284 |
T1639 |
T86652 |
arg2Of |
humans,into |
R12844 |
T18459 |
T55071 |
arg1Of |
This,revealed |
R1285 |
T1639 |
T23535 |
arg1Of |
humans,"," |
R1286 |
T1639 |
T51241 |
arg1Of |
humans,where |
R12860 |
T24662 |
T14862 |
arg1Of |
GPC,LASV |
R1287 |
T59854 |
T51241 |
arg2Of |
circulated,where |
R1288 |
T67194 |
T59854 |
arg1Of |
it,circulated |
R1289 |
T59854 |
T82528 |
arg1Of |
circulated,transiently |
R129 |
T133 |
T132 |
arg1Of |
hemagglutinin,influenza |
R1290 |
T1281 |
T23126 |
arg1Of |
corresponded,In |
R1291 |
T4625 |
T23126 |
arg2Of |
contrast,In |
R12914 |
T15993 |
T99830 |
arg1Of |
presence,hindered |
R1292 |
T1281 |
T47309 |
arg1Of |
corresponded,"," |
R1293 |
T1280 |
T1278 |
arg1Of |
outbreak,the |
R1294 |
T1280 |
T1279 |
arg1Of |
outbreak,SARS |
R1295 |
T1280 |
T1281 |
arg1Of |
outbreak,corresponded |
R12958 |
T7069 |
T2785 |
arg1Of |
correspond,while |
R1296 |
T1281 |
T1282 |
arg1Of |
corresponded,to |
R1297 |
T1286 |
T1282 |
arg2Of |
event,to |
R1298 |
T1286 |
T1283 |
arg1Of |
event,a |
R1299 |
T1286 |
T1284 |
arg1Of |
event,single |
R13 |
T12 |
T16 |
arg1Of |
syndrome,and |
R130 |
T131 |
T134 |
arg1Of |
and,"," |
R1300 |
T1286 |
T1285 |
arg1Of |
event,zoonotic |
R13007 |
T81517 |
T14224 |
arg2Of |
SIVcpz,( |
R1301 |
T1291 |
T1287 |
arg1Of |
transmission,followed |
R1302 |
T1286 |
T1287 |
arg2Of |
event,followed |
R1303 |
T1291 |
T1288 |
arg2Of |
transmission,by |
R13031 |
T2204 |
T67682 |
arg1Of |
sites,potential |
R1304 |
T1291 |
T1289 |
arg1Of |
transmission,extensive |
R1305 |
T1291 |
T1290 |
arg1Of |
transmission,human-to-human |
R1306 |
T1307 |
T1292 |
arg1Of |
is,Consequently |
R1307 |
T1307 |
T1293 |
arg1Of |
is,"," |
R1308 |
T1296 |
T1294 |
arg2Of |
degree,inferring |
R1309 |
T1296 |
T1295 |
arg1Of |
degree,the |
R131 |
T131 |
T135 |
arg1Of |
and,where |
R1310 |
T1296 |
T1297 |
arg1Of |
degree,of |
R1311 |
T1298 |
T1297 |
arg2Of |
selection,of |
R1312 |
T1296 |
T1299 |
arg1Of |
degree,acting |
R13123 |
T60433 |
T21150 |
arg1Of |
calculated,by |
R1313 |
T1299 |
T1300 |
arg1Of |
acting,upon |
R1314 |
T1302 |
T1300 |
arg2Of |
and,upon |
R1315 |
T1301 |
T1302 |
arg1Of |
MERS,and |
R1316 |
T1303 |
T1302 |
arg2Of |
SARS,and |
R13160 |
T63465 |
T42025 |
arg1Of |
virus,strong” |
R1317 |
T1296 |
T1304 |
arg1Of |
degree,from |
R13176 |
T55156 |
T17381 |
arg1Of |
vulnerabilities,extensive |
R1318 |
T1306 |
T1304 |
arg2Of |
analysis,from |
R1319 |
T1306 |
T1305 |
arg1Of |
analysis,dN/dS |
R132 |
T137 |
T135 |
arg2Of |
plays,where |
R1320 |
T1294 |
T1307 |
arg1Of |
inferring,is |
R13200 |
T14141 |
T19161 |
arg1Of |
presence,reminiscent |
R1321 |
T1309 |
T1307 |
arg2Of |
difficult,is |
R1322 |
T1309 |
T1308 |
arg1Of |
difficult,extremely |
R13220 |
T87524 |
T52826 |
arg2Of |
immunization,upon |
R1323 |
T1294 |
T1309 |
arg1Of |
inferring,difficult |
R1324 |
T1358 |
T1310 |
arg1Of |
be,Importantly |
R1325 |
T1358 |
T1311 |
arg1Of |
be,"," |
R1326 |
T1358 |
T1312 |
arg1Of |
be,while |
R1327 |
T1317 |
T1312 |
arg2Of |
is,while |
R1328 |
T1314 |
T1313 |
arg1Of |
analyses,similar |
R13280 |
T7859 |
T53325 |
arg2Of |
neutralising,of |
R1329 |
T1314 |
T1315 |
arg1Of |
analyses,of |
R13295 |
T28741 |
T83177 |
arg1Of |
mapping,of |
R133 |
T136 |
T137 |
arg1Of |
glycosylation,plays |
R1330 |
T1316 |
T1315 |
arg2Of |
SARS-CoV-2,of |
R1331 |
T1314 |
T1317 |
arg1Of |
analyses,is |
R1332 |
T1318 |
T1317 |
arg2Of |
desirable,is |
R1333 |
T1314 |
T1318 |
arg1Of |
analyses,desirable |
R13336 |
T19047 |
T57723 |
arg1Of |
analysis,cryo-EM |
R1334 |
T1317 |
T1319 |
arg1Of |
is,"," |
R1335 |
T1321 |
T1320 |
arg1Of |
to,due |
R1336 |
T27779 |
T77953 |
arg1Of |
available,publicly |
R13361 |
T93669 |
T34640 |
arg2Of |
compositions,determined |
R1337 |
T1325 |
T1321 |
arg2Of |
variation,to |
R1338 |
T1325 |
T1322 |
arg1Of |
variation,the |
R13388 |
T50688 |
T24947 |
arg1Of |
yield,to |
R1339 |
T1324 |
T1323 |
arg1Of |
genetic,low |
R134 |
T140 |
T137 |
arg2Of |
role,plays |
R1340 |
T1325 |
T1324 |
arg1Of |
variation,genetic |
R13402 |
T35349 |
T72864 |
arg1Of |
subunits,S1 |
R1341 |
T1317 |
T1326 |
arg1Of |
is,among |
R13410 |
T81231 |
T66143 |
arg1Of |
considered,only |
R1342 |
T1330 |
T1326 |
arg2Of |
sequences,among |
R1343 |
T1330 |
T1327 |
arg1Of |
sequences,the |
R1344 |
T1330 |
T1328 |
arg1Of |
sequences,current |
R1345 |
T1330 |
T1329 |
arg1Of |
sequences,SARS-CoV-2 |
R1346 |
T1330 |
T1331 |
arg1Of |
sequences,( |
R1347 |
T1332 |
T1331 |
arg2Of |
as,( |
R1348 |
T1337 |
T1331 |
arg3Of |
),( |
R1349 |
T1335 |
T1332 |
arg2Of |
March,as |
R135 |
T140 |
T138 |
arg1Of |
role,a |
R1350 |
T1334 |
T1333 |
arg1Of |
17,of |
R1351 |
T1335 |
T1334 |
arg1Of |
March,17 |
R13511 |
T66804 |
T63689 |
arg2Of |
surface,exposed |
R1352 |
T1335 |
T1336 |
arg1Of |
March,2020 |
R1353 |
T1330 |
T1338 |
arg1Of |
sequences,"," |
R13531 |
T59603 |
T7211 |
arg1Of |
values,( |
R1354 |
T1330 |
T1339 |
arg1Of |
sequences,which |
R1355 |
T1341 |
T1340 |
arg1Of |
include,likely |
R1356 |
T1330 |
T1341 |
arg1Of |
sequences,include |
R13565 |
T31010 |
T11561 |
arg1Of |
correlation,strong |
R1357 |
T1343 |
T1341 |
arg2Of |
mutations,include |
R1358 |
T1343 |
T1342 |
arg1Of |
mutations,deleterious |
R1359 |
T1343 |
T1344 |
arg1Of |
mutations,that |
R136 |
T140 |
T139 |
arg2Of |
role,known |
R1360 |
T1343 |
T79570 |
arg1Of |
mutations,will |
R1361 |
T1347 |
T79570 |
arg2Of |
removed,will |
R1362 |
T1343 |
T1346 |
arg1Of |
mutations,be |
R1363 |
T1347 |
T1346 |
arg2Of |
removed,be |
R1364 |
T1349 |
T1347 |
arg1Of |
selection,removed |
R13642 |
T40801 |
T50374 |
arg1Of |
are,not |
R13645 |
T19690 |
T7181 |
arg2Of |
weight,by |
R1365 |
T1343 |
T1347 |
arg2Of |
mutations,removed |
R1366 |
T1349 |
T1348 |
arg2Of |
selection,by |
R1367 |
T1347 |
T1350 |
arg1Of |
removed,over |
R1368 |
T1351 |
T1350 |
arg2Of |
time,over |
R13680 |
T53788 |
T33383 |
arg1Of |
functionality,intrinsic |
R13682 |
T4923 |
T38815 |
arg1Of |
inventors,on |
R1369 |
T1358 |
T1352 |
arg1Of |
be,"," |
R137 |
T137 |
T141 |
arg1Of |
plays,in |
R1370 |
T1356 |
T1353 |
arg1Of |
analyses,the |
R1371 |
T1356 |
T1354 |
arg1Of |
analyses,resulting |
R1372 |
T1356 |
T1355 |
arg1Of |
analyses,bioinformatic |
R13725 |
T39562 |
T27512 |
arg1Of |
b,SPARX |
R13727 |
T54604 |
T37933 |
arg2Of |
viruses,and |
R1373 |
T1356 |
T1357 |
arg1Of |
analyses,would |
R13730 |
T54044 |
T8441 |
arg2Of |
evasion,in |
R1374 |
T1358 |
T1357 |
arg2Of |
be,would |
R1375 |
T1356 |
T1358 |
arg1Of |
analyses,be |
R1376 |
T1359 |
T1358 |
arg2Of |
unreliable,be |
R1377 |
T1356 |
T1359 |
arg1Of |
analyses,unreliable |
R1378 |
T1363 |
T1360 |
arg2Of |
and,Visualising |
R13781 |
T51449 |
T4483 |
arg1Of |
proteins,fusion |
R1379 |
T1363 |
T1361 |
arg1Of |
and,the |
R138 |
T142 |
T141 |
arg2Of |
shielding,in |
R1380 |
T1362 |
T1363 |
arg1Of |
HIV-1,and |
R1381 |
T1366 |
T1363 |
arg2Of |
shields,and |
R1382 |
T1366 |
T1364 |
arg1Of |
shields,SARS |
R1383 |
T1366 |
T1365 |
arg1Of |
shields,glycan |
R1384 |
T1363 |
T1367 |
arg1Of |
and,by |
R1385 |
T1368 |
T1367 |
arg2Of |
cryo-EM,by |
R1386 |
T48978 |
T21297 |
arg2Of |
antibodies67.Viruses,of |
R1387 |
T47145 |
T77941 |
arg1Of |
neutralizing,broadly |
R1388 |
T48978 |
T47145 |
arg1Of |
antibodies67.Viruses,neutralizing |
R1389 |
T48978 |
T78349 |
arg2Of |
antibodies67.Viruses,classified |
R139 |
T144 |
T142 |
arg2Of |
epitopes,shielding |
R1390 |
T78349 |
T84508 |
arg1Of |
classified,as |
R1391 |
T94485 |
T84508 |
arg2Of |
"strong”26,56",as |
R1392 |
T94485 |
T99687 |
arg1Of |
"strong”26,56",“evasion |
R1393 |
T80263 |
T8371 |
arg1Of |
development,may |
R1394 |
T19557 |
T8371 |
arg2Of |
differ,may |
R1395 |
T19557 |
T70765 |
arg1Of |
differ,then |
R1396 |
T80263 |
T19557 |
arg1Of |
development,differ |
R1397 |
T58964 |
T68211 |
arg1Of |
to,due |
R1398 |
T19557 |
T58964 |
arg1Of |
differ,to |
R1399 |
T28724 |
T58964 |
arg2Of |
efficacies,to |
R14 |
T20 |
T16 |
arg2Of |
syndrome,and |
R140 |
T144 |
T143 |
arg1Of |
epitopes,immunogenic |
R1400 |
T28724 |
T91845 |
arg1Of |
efficacies,varied |
R1401 |
T29672 |
T24787 |
arg1Of |
datasets,cryo-EM |
R14014 |
T1508 |
T33829 |
arg1Of |
boundaries,diffuse |
R1402 |
T91764 |
T35775 |
arg2Of |
shielding,of |
R1403 |
T91764 |
T42494 |
arg1Of |
shielding,protein |
R1404 |
T91764 |
T48391 |
arg1Of |
shielding,surface |
R1405 |
T97622 |
T4001 |
arg1Of |
comparisons,meaningful |
R14059 |
T71776 |
T64977 |
arg2Of |
interactions,of |
R1406 |
T1370 |
T1369 |
arg2Of |
glycans,by |
R1407 |
T1375 |
T1371 |
arg1Of |
adds,Overall |
R14070 |
T7550 |
T70799 |
arg1Of |
accumulation,of |
R1408 |
T1375 |
T1372 |
arg1Of |
adds,"," |
R14083 |
T52475 |
T17084 |
arg1Of |
conservation,on |
R1409 |
T1374 |
T1373 |
arg1Of |
study,this |
R141 |
T149 |
T145 |
arg1Of |
reveal,Overall |
R1410 |
T29096 |
T42685 |
arg1Of |
modifications,the |
R1411 |
T1377 |
T1375 |
arg2Of |
evidence,adds |
R1412 |
T1377 |
T1376 |
arg1Of |
evidence,further |
R1413 |
T1377 |
T1378 |
arg1Of |
evidence,suggesting |
R1414 |
T1393 |
T1378 |
arg2Of |
constitute,suggesting |
R14145 |
T18648 |
T52275 |
arg2Of |
interactions,reveal |
R1415 |
T1393 |
T1379 |
arg1Of |
constitute,that |
R1416 |
T1383 |
T1380 |
arg1Of |
modifications,extensive |
R1417 |
T1383 |
T1381 |
arg1Of |
modifications,N-linked |
R1418 |
T1383 |
T1382 |
arg1Of |
modifications,glycan |
R14182 |
T35915 |
T84730 |
arg1Of |
structure,the |
R1419 |
T1383 |
T1384 |
arg1Of |
modifications,of |
R142 |
T149 |
T146 |
arg1Of |
reveal,"," |
R1420 |
T1390 |
T1384 |
arg2Of |
proteins,of |
R1421 |
T1390 |
T47921 |
arg1Of |
proteins,SARS |
R14219 |
T32211 |
T36441 |
arg1Of |
elicit,"," |
R1422 |
T47921 |
T1386 |
arg1Of |
SARS,and |
R14228 |
T85438 |
T20968 |
arg1Of |
",",and |
R1423 |
T1387 |
T1386 |
arg2Of |
MERS,and |
R1424 |
T1390 |
T1387 |
arg1Of |
proteins,MERS |
R1425 |
T1390 |
T1388 |
arg1Of |
proteins,CoV |
R1426 |
T1390 |
T1389 |
arg1Of |
proteins,S |
R14263 |
T16458 |
T39264 |
arg1Of |
dataset52,SARS |
R1427 |
T1383 |
T1391 |
arg1Of |
modifications,do |
R1428 |
T1393 |
T1391 |
arg2Of |
constitute,do |
R1429 |
T1393 |
T1392 |
arg1Of |
constitute,not |
R143 |
T148 |
T147 |
arg1Of |
data,our |
R1430 |
T1383 |
T1393 |
arg1Of |
modifications,constitute |
R1431 |
T1396 |
T1393 |
arg2Of |
shield,constitute |
R1432 |
T1396 |
T1394 |
arg1Of |
shield,an |
R1433 |
T1396 |
T1395 |
arg1Of |
shield,effective |
R1434 |
T1393 |
T1397 |
arg1Of |
constitute,"," |
R1435 |
T1393 |
T1398 |
arg1Of |
constitute,in |
R1436 |
T1399 |
T1398 |
arg2Of |
comparison,in |
R14360 |
T44352 |
T99300 |
arg2Of |
shielding,of |
R1437 |
T1399 |
T1400 |
arg1Of |
comparison,to |
R1438 |
T1402 |
T1400 |
arg2Of |
shields,to |
R14380 |
T56088 |
T68265 |
arg1Of |
Proteins,“Prefusion |
R1439 |
T1402 |
T1401 |
arg1Of |
shields,glycan |
R14394 |
T75003 |
T7467 |
arg1Of |
data,that |
R144 |
T148 |
T149 |
arg1Of |
data,reveal |
R1440 |
T1402 |
T1403 |
arg1Of |
shields,of |
R1441 |
T1406 |
T1403 |
arg2Of |
viruses,of |
R14418 |
T86335 |
T7181 |
arg1Of |
glycan,by |
R1442 |
T1406 |
T1404 |
arg1Of |
viruses,certain |
R14422 |
T69877 |
T33142 |
arg2Of |
trimers,as |
R14427 |
T14374 |
T44329 |
arg1Of |
graphs,bar |
R1443 |
T1406 |
T1405 |
arg1Of |
viruses,other |
R1444 |
T1377 |
T1407 |
arg1Of |
evidence,"," |
R1445 |
T1377 |
T1408 |
arg1Of |
evidence,which |
R14458 |
T6494 |
T33346 |
arg2Of |
sites,for |
R1446 |
T1377 |
T1409 |
arg1Of |
evidence,is |
R1447 |
T1410 |
T1409 |
arg2Of |
reflected,is |
R14478 |
T10370 |
T60922 |
arg2Of |
density,for |
R1448 |
T1414 |
T1410 |
arg1Of |
structure,reflected |
R1449 |
T1377 |
T1410 |
arg2Of |
evidence,reflected |
R145 |
T166 |
T149 |
arg2Of |
but,reveal |
R1450 |
T1414 |
T1411 |
arg2Of |
structure,by |
R14505 |
T91428 |
T10009 |
arg1Of |
we,studied |
R1451 |
T1414 |
T1412 |
arg1Of |
structure,the |
R1452 |
T1414 |
T1413 |
arg1Of |
structure,overall |
R14520 |
T10370 |
T57613 |
arg1Of |
density,global |
R1453 |
T1414 |
T1415 |
arg1Of |
structure,"," |
R14533 |
T30171 |
T64135 |
arg2Of |
6OHY,"," |
R1454 |
T1417 |
T1415 |
arg2Of |
and,"," |
R1455 |
T1416 |
T1417 |
arg1Of |
density,and |
R1456 |
T1419 |
T1417 |
arg2Of |
abundance,and |
R1457 |
T1419 |
T1418 |
arg1Of |
abundance,oligomannose |
R14572 |
T77334 |
T68472 |
arg1Of |
We,using |
R1458 |
T1417 |
T1420 |
arg1Of |
and,across |
R14580 |
T38160 |
T20315 |
arg1Of |
",","," |
R1459 |
T1424 |
T1420 |
arg2Of |
glycoproteins,across |
R14590 |
T72680 |
T6297 |
arg2Of |
linked,is |
R14595 |
T20998 |
T24864 |
arg1Of |
regions,patch |
R146 |
T160 |
T150 |
arg1Of |
influence,how |
R1460 |
T1424 |
T1421 |
arg1Of |
glycoproteins,the |
R1461 |
T1424 |
T1422 |
arg1Of |
glycoproteins,corresponding |
R1462 |
T1424 |
T1423 |
arg1Of |
glycoproteins,trimeric |
R1463 |
T1427 |
T1426 |
arg1Of |
demonstrate,also |
R1464 |
T1425 |
T1427 |
arg1Of |
We,demonstrate |
R1465 |
T1432 |
T1427 |
arg2Of |
occurs,demonstrate |
R14652 |
T90347 |
T69433 |
arg1Of |
proteins,coronavirus |
R1466 |
T1432 |
T1428 |
arg1Of |
occurs,that |
R1467 |
T1430 |
T1429 |
arg1Of |
diversification,amino-acid |
R14674 |
T68539 |
T22023 |
arg1Of |
glycans,been |
R1468 |
T1432 |
T1431 |
arg1Of |
occurs,indeed |
R1469 |
T1430 |
T1432 |
arg1Of |
diversification,occurs |
R147 |
T151 |
T152 |
arg1Of |
organisation,of |
R1470 |
T1432 |
T1433 |
arg1Of |
occurs,at |
R14706 |
T30294 |
T51996 |
arg2Of |
densities,calculated |
R1471 |
T1436 |
T1433 |
arg2Of |
regions,at |
R1472 |
T1436 |
T1434 |
arg1Of |
regions,antibody |
R1473 |
T19555 |
T26714 |
arg1Of |
importance,of |
R1474 |
T1436 |
T1437 |
arg1Of |
regions,on |
R14742 |
T17551 |
T54237 |
arg1Of |
shields,glycan |
R1475 |
T1439 |
T1437 |
arg2Of |
trimer,on |
R1476 |
T1439 |
T1438 |
arg1Of |
trimer,the |
R1477 |
T1439 |
T1440 |
arg1Of |
trimer,"," |
R1478 |
T1439 |
T1441 |
arg1Of |
trimer,which |
R1479 |
T1439 |
T1442 |
arg1Of |
trimer,confirms |
R148 |
T153 |
T152 |
arg2Of |
glycosylation,of |
R1480 |
T1445 |
T1442 |
arg2Of |
play,confirms |
R1481 |
T1445 |
T1443 |
arg1Of |
play,that |
R1482 |
T1444 |
T1445 |
arg1Of |
glycans,play |
R1483 |
T1447 |
T1445 |
arg2Of |
role,play |
R1484 |
T1447 |
T1446 |
arg1Of |
role,a |
R1485 |
T1445 |
T1448 |
arg1Of |
play,in |
R14857 |
T50530 |
T67487 |
arg2Of |
lack,and |
R1486 |
T1449 |
T1448 |
arg2Of |
occluding,in |
R1487 |
T1451 |
T1449 |
arg2Of |
regions,occluding |
R14872 |
T15993 |
T79196 |
arg2Of |
presence,by |
R1488 |
T1451 |
T1450 |
arg1Of |
regions,specific |
R1489 |
T1451 |
T1452 |
arg1Of |
regions,if |
R149 |
T151 |
T154 |
arg1Of |
organisation,across |
R1490 |
T1453 |
T1452 |
arg2Of |
vulnerability,if |
R14902 |
T75554 |
T98585 |
arg1Of |
spikes,coronavirus |
R1491 |
T1453 |
T1454 |
arg1Of |
vulnerability,on |
R1492 |
T1456 |
T1454 |
arg2Of |
glycoprotein,on |
R1493 |
T1456 |
T1455 |
arg1Of |
glycoprotein,the |
R1494 |
T1478 |
T1457 |
arg1Of |
and,Furthermore |
R1495 |
T1478 |
T1458 |
arg1Of |
and,"," |
R1496 |
T1459 |
T1460 |
arg1Of |
comparisons,between |
R1497 |
T1462 |
T1460 |
arg2Of |
shields,between |
R1498 |
T1462 |
T1461 |
arg1Of |
shields,glycan |
R1499 |
T1462 |
T1463 |
arg1Of |
shields,from |
R15 |
T18 |
T17 |
arg1Of |
East,Middle |
R150 |
T159 |
T154 |
arg2Of |
proteins,across |
R1500 |
T1465 |
T1463 |
arg2Of |
number,from |
R1501 |
T1465 |
T1464 |
arg1Of |
number,a |
R1502 |
T1465 |
T1466 |
arg1Of |
number,of |
R1503 |
T1467 |
T1466 |
arg2Of |
viruses,of |
R1504 |
T1459 |
T1468 |
arg1Of |
comparisons,highlight |
R15047 |
T97839 |
T6523 |
arg1Of |
note,interesting |
R15048 |
T69932 |
T42110 |
arg1Of |
define,to |
R1505 |
T1470 |
T1468 |
arg2Of |
importance,highlight |
R1506 |
T1470 |
T1469 |
arg1Of |
importance,the |
R1507 |
T1470 |
T1471 |
arg1Of |
importance,of |
R1508 |
T1474 |
T1471 |
arg2Of |
shield,of |
R15085 |
T88882 |
T76117 |
arg1Of |
subject,to |
R1509 |
T1474 |
T1472 |
arg1Of |
shield,a |
R151 |
T159 |
T155 |
arg1Of |
proteins,class |
R1510 |
T1474 |
T1473 |
arg1Of |
shield,glycan |
R1511 |
T1474 |
T1475 |
arg1Of |
shield,in |
R1512 |
T1477 |
T1475 |
arg2Of |
evasion,in |
R1513 |
T1477 |
T1476 |
arg1Of |
evasion,immune |
R1514 |
T77242 |
T85214 |
arg2Of |
S,and |
R1515 |
T1479 |
T1478 |
arg2Of |
reveal,and |
R1516 |
T1459 |
T1479 |
arg1Of |
comparisons,reveal |
R1517 |
T1481 |
T1479 |
arg2Of |
principles,reveal |
R1518 |
T1481 |
T1480 |
arg1Of |
principles,structural |
R1519 |
T1481 |
T1482 |
arg1Of |
principles,that |
R152 |
T159 |
T156 |
arg1Of |
proteins,I |
R1520 |
T1481 |
T1483 |
arg1Of |
principles,govern |
R1521 |
T1485 |
T1483 |
arg2Of |
status,govern |
R15217 |
T98451 |
T72837 |
arg1Of |
diversities,were |
R15219 |
T19555 |
T1601 |
arg1Of |
importance,been |
R1522 |
T1485 |
T1484 |
arg1Of |
status,glycosylation |
R15227 |
T84875 |
T83072 |
arg1Of |
generated,"," |
R1523 |
T1487 |
T1488 |
arg1Of |
Expression,and |
R15238 |
T28741 |
T27583 |
arg1Of |
mapping,11 glycoproteins. Structural-based |
R1524 |
T1489 |
T1488 |
arg2Of |
purification,and |
R1525 |
T1488 |
T1490 |
arg1Of |
and,of |
R15252 |
T7879 |
T87072 |
arg1Of |
structure,the |
R1526 |
T1493 |
T1490 |
arg2Of |
glycoproteins,of |
R1527 |
T1493 |
T1491 |
arg1Of |
glycoproteins,coronavirus |
R15276 |
T10053 |
T41377 |
arg1Of |
speculate,for |
R1528 |
T1493 |
T1492 |
arg1Of |
glycoproteins,spike |
R153 |
T159 |
T157 |
arg1Of |
proteins,viral |
R15307 |
T82356 |
T8758 |
arg1Of |
diversity,Amino-acid |
R15309 |
T83803 |
T92642 |
arg2Of |
M9,( |
R15321 |
T95182 |
T88912 |
arg1Of |
",",compared |
R15327 |
T31301 |
T73600 |
arg1Of |
and,"," |
R15347 |
T96477 |
T7804 |
arg2Of |
amino-acids,of |
R15384 |
T81925 |
T31179 |
arg2Of |
proteins,and |
R154 |
T159 |
T158 |
arg1Of |
proteins,fusion |
R15450 |
T98451 |
T74584 |
arg1Of |
diversities,per-site |
R15452 |
T27050 |
T89403 |
arg2Of |
microscopy,used |
R15459 |
T67976 |
T12260 |
arg1Of |
glycome,of |
R155 |
T151 |
T160 |
arg1Of |
organisation,influence |
R15545 |
T87865 |
T32032 |
arg1Of |
observed,experimentally |
R15555 |
T39941 |
T13595 |
arg1Of |
genes,spike |
R156 |
T165 |
T160 |
arg2Of |
compositions,influence |
R15611 |
T4820 |
T60050 |
arg1Of |
observed,experimentally |
R15613 |
T95495 |
T73178 |
arg1Of |
grey,dark |
R15619 |
T72369 |
T13118 |
arg1Of |
substitutions,synonymous |
R15665 |
T37921 |
T34206 |
arg1Of |
glycans,fewer |
R15678 |
T59734 |
T50969 |
arg1Of |
constraints,limit |
R157 |
T162 |
T161 |
arg1Of |
only,not |
R15715 |
T25304 |
T83161 |
arg1Of |
sequences,gene |
R1577 |
T86504 |
T76573 |
arg2Of |
alkylated,"," |
R158 |
T165 |
T162 |
arg1Of |
compositions,only |
R15842 |
T77976 |
T39650 |
arg3Of |
),( |
R15889 |
T1566 |
T58559 |
arg1Of |
opposed,to |
R1589 |
T75686 |
T16671 |
arg1Of |
proteins,S |
R159 |
T165 |
T163 |
arg1Of |
compositions,individual |
R1590 |
T54985 |
T54383 |
arg1Of |
proteins,S |
R15971 |
T54061 |
T35585 |
arg1Of |
proteins,SARS |
R16 |
T20 |
T18 |
arg1Of |
syndrome,East |
R160 |
T165 |
T164 |
arg1Of |
compositions,glycan |
R16019 |
T56943 |
T93082 |
arg2Of |
them,adding |
R16052 |
T11220 |
T31109 |
arg1Of |
dynamics,therefore |
R16055 |
T43156 |
T80529 |
arg1Of |
intervals,posterior |
R16084 |
T29000 |
T84846 |
arg1Of |
sparser,considerably |
R16092 |
T20594 |
T76109 |
arg1Of |
residues,undergoing |
R161 |
T150 |
T166 |
arg1Of |
how,but |
R16112 |
T50640 |
T17100 |
arg2Of |
and,with |
R16162 |
T10541 |
T7434 |
arg2Of |
viruses,between |
R1617 |
T65828 |
T1385 |
arg2Of |
residues,exposed |
R16170 |
T96660 |
T18812 |
arg1Of |
and,"," |
R162 |
T170 |
T166 |
arg2Of |
pressure,but |
R1625 |
T93681 |
T72733 |
modOf |
HAs,replacing |
R16270 |
T32624 |
T57322 |
arg1Of |
diversity,and |
R16285 |
T72412 |
T77964 |
arg2Of |
why,understanding |
R163 |
T166 |
T167 |
arg1Of |
but,also |
R16310 |
T22368 |
T83476 |
arg1Of |
25,% |
R16314 |
T64331 |
T35591 |
arg1Of |
ratios,of |
R16336 |
T80158 |
T82660 |
arg2Of |
SI,( |
R164 |
T170 |
T168 |
arg1Of |
pressure,the |
R16454 |
T17681 |
T76597 |
arg1Of |
candidates,many |
R16468 |
T86925 |
T55384 |
arg2Of |
series,with |
R165 |
T170 |
T169 |
arg1Of |
pressure,immunological |
R16504 |
T2686 |
T88226 |
arg1Of |
shield,glycan |
R16533 |
T87179 |
T16494 |
arg1Of |
receptor-binding,and |
R16567 |
T9264 |
T70541 |
arg1Of |
reveal,and |
R166 |
T170 |
T171 |
arg1Of |
pressure,across |
R16607 |
T87051 |
T82847 |
arg1Of |
it,performing |
R16608 |
T94778 |
T33023 |
arg1Of |
as,such |
R16669 |
T76361 |
T69629 |
arg1Of |
proteins,coronavirus |
R16680 |
T61476 |
T68346 |
arg1Of |
residues,amino-acid |
R167 |
T174 |
T171 |
arg2Of |
surface,across |
R16719 |
T47420 |
T67617 |
arg1Of |
number,by |
R16738 |
T43420 |
T94778 |
arg2Of |
and,as |
R16751 |
T66049 |
T12116 |
arg1Of |
shield,glycan |
R168 |
T174 |
T172 |
arg1Of |
surface,the |
R16805 |
T17681 |
T40686 |
arg1Of |
candidates,produce |
R16806 |
T44869 |
T14663 |
arg1Of |
in,especially |
R1686 |
T72393 |
T49131 |
arg1Of |
reprocessed,for |
R16879 |
T86817 |
T18984 |
arg1Of |
",","," |
R16896 |
T54925 |
T93480 |
arg1Of |
analyses,83 |
R169 |
T174 |
T173 |
arg1Of |
surface,protein |
R1691 |
T32211 |
T66786 |
arg1Of |
elicit,readily |
R16925 |
T69499 |
T83087 |
arg1Of |
Analysis,revealed |
R17 |
T20 |
T19 |
arg1Of |
syndrome,respiratory |
R170 |
T175 |
T176 |
arg1Of |
Glycosylation,plays |
R17066 |
T16685 |
T55814 |
arg1Of |
is,and |
R17073 |
T88079 |
T2448 |
arg2Of |
5X58,( |
R171 |
T179 |
T176 |
arg2Of |
role,plays |
R17114 |
T25443 |
T97762 |
arg1Of |
MERS,was |
R17152 |
T17645 |
T50138 |
arg1Of |
sites,glycosylation |
R17171 |
T38543 |
T43155 |
arg2Of |
glycosylated,are |
R17192 |
T65590 |
T39600 |
arg2Of |
5I08,"," |
R172 |
T179 |
T177 |
arg1Of |
role,a |
R17257 |
T60774 |
T72458 |
arg1Of |
sites,N-linked |
R17294 |
T10460 |
T54967 |
arg1Of |
and,"," |
R173 |
T179 |
T178 |
arg1Of |
role,key |
R17315 |
T88607 |
T60015 |
arg1Of |
We,hypothesized |
R17326 |
T81576 |
T74525 |
arg2Of |
underprocessed,but |
R174 |
T176 |
T180 |
arg1Of |
plays,in |
R17472 |
T56514 |
T39313 |
arg1Of |
population,the |
R175 |
T181 |
T180 |
arg2Of |
shielding,in |
R17506 |
T87991 |
T17443 |
arg3Of |
),( |
R17597 |
T19555 |
T74546 |
arg2Of |
importance,investigated |
R176 |
T181 |
T182 |
arg1Of |
shielding,of |
R17624 |
T40146 |
T80516 |
arg2Of |
evasion,aid |
R17631 |
T16169 |
T29335 |
arg1Of |
interpretability,the |
R17670 |
T72197 |
T88581 |
arg1Of |
glycoproteins,different |
R177 |
T184 |
T182 |
arg2Of |
epitopes,of |
R17713 |
T75686 |
T13582 |
arg2Of |
proteins,and |
R1774 |
T16169 |
T54909 |
arg1Of |
interpretability,of |
R17754 |
T32200 |
T61088 |
arg1Of |
antibodies,targeted |
R17774 |
T79412 |
T54950 |
arg1Of |
is,"," |
R17775 |
T26472 |
T18939 |
arg1Of |
subunit,between |
R17784 |
T82842 |
T94035 |
arg1Of |
5X59,and |
R178 |
T184 |
T183 |
arg1Of |
epitopes,immunogenic |
R17818 |
T17113 |
T15012 |
arg2Of |
proteins,Purified |
R17876 |
T99242 |
T42499 |
arg2Of |
head,on |
R179 |
T181 |
T185 |
arg1Of |
shielding,on |
R17920 |
T78856 |
T67170 |
arg2Of |
research,in |
R17934 |
T86925 |
T19908 |
arg1Of |
series,glycan |
R1794 |
T7879 |
T75651 |
arg1Of |
structure,of |
R17970 |
T74594 |
T32963 |
arg1Of |
structure,of |
R17994 |
T76109 |
T87805 |
arg2Of |
undergoing,be |
R18 |
T20 |
T21 |
arg1Of |
syndrome,( |
R180 |
T191 |
T185 |
arg2Of |
proteins,on |
R18003 |
T14034 |
T76136 |
arg2Of |
processing,increased |
R18040 |
T8574 |
T96535 |
arg1Of |
highlighted,throughout |
R18043 |
T14374 |
T86682 |
arg1Of |
graphs,The |
R18044 |
T47125 |
T30265 |
arg2Of |
results,reproduced |
R18076 |
T61501 |
T25318 |
arg2Of |
",",of |
R181 |
T187 |
T186 |
arg1Of |
spike,viral |
R18121 |
T68396 |
T90251 |
arg2Of |
MS,by |
R18139 |
T92287 |
T2494 |
arg1Of |
exhibited,that |
R18142 |
T80657 |
T46816 |
arg1Of |
protein,that |
R18144 |
T2440 |
T89662 |
arg1Of |
glycoproteins,S |
R182 |
T191 |
T187 |
arg1Of |
proteins,spike |
R18240 |
T56088 |
T56201 |
arg1Of |
Proteins,and |
R18285 |
T72291 |
T87030 |
arg1Of |
colored,"," |
R18293 |
T88079 |
T12743 |
arg1Of |
5X58,ID |
R183 |
T187 |
T188 |
arg1Of |
spike,( |
R18321 |
T88747 |
T79957 |
arg2Of |
observed,been |
R18386 |
T89744 |
T37340 |
arg1Of |
antibodies,targeting |
R184 |
T189 |
T188 |
arg2Of |
S,( |
R18448 |
T35349 |
T72291 |
arg2Of |
subunits,colored |
R18453 |
T80844 |
T21892 |
arg1Of |
networks,the |
R185 |
T190 |
T188 |
arg3Of |
),( |
R18524 |
T46478 |
T60028 |
arg1Of |
domain,each |
R18543 |
T92271 |
T41451 |
arg1Of |
rate66,the |
R18556 |
T86418 |
T9745 |
arg2Of |
defined,as |
R186 |
T196 |
T192 |
arg1Of |
report,Here |
R18633 |
T82481 |
T42862 |
arg1Of |
subunit,S1 |
R18674 |
T93319 |
T88231 |
arg1Of |
domains,"," |
R187 |
T195 |
T193 |
arg1Of |
al.,Watanabe |
R18729 |
T66354 |
T72680 |
arg2Of |
shielding,linked |
R18750 |
T9951 |
T15001 |
arg1Of |
located,on |
R18785 |
T39465 |
T17574 |
arg1Of |
“shields”,the |
R188 |
T195 |
T194 |
arg1Of |
al.,et |
R18805 |
T14361 |
T29834 |
arg2Of |
outbreak,within |
R18813 |
T2440 |
T47096 |
arg1Of |
glycoproteins,b |
R18814 |
T61777 |
T13379 |
arg1Of |
maps,both |
R18870 |
T43889 |
T37781 |
arg1Of |
GPC24,LASV |
R18888 |
T49302 |
T7289 |
arg1Of |
server,( |
R189 |
T195 |
T196 |
arg1Of |
al.,report |
R18918 |
T92110 |
T35748 |
arg1Of |
glycans,on |
R18920 |
T33538 |
T23766 |
arg1Of |
glycosylation,reach |
R18949 |
T44762 |
T97123 |
arg1Of |
labelled,with |
R18950 |
T73114 |
T38463 |
arg1Of |
compare,it |
R18961 |
T18666 |
T25962 |
arg2Of |
spectrometry,to |
R19 |
T22 |
T21 |
arg2Of |
MERS,( |
R190 |
T209 |
T196 |
arg2Of |
and,report |
R19033 |
T82693 |
T72819 |
arg1Of |
and,"," |
R19042 |
T80657 |
T55541 |
arg1Of |
protein,a |
R19054 |
T15422 |
T38271 |
arg1Of |
surface,proteinaceous |
R191 |
T209 |
T197 |
arg1Of |
and,that |
R19111 |
T49977 |
T8049 |
arg2Of |
responses,and |
R19115 |
T45890 |
T78652 |
arg3Of |
),( |
R19195 |
T69491 |
T78299 |
arg1Of |
estimates,dN/dS |
R192 |
T198 |
T199 |
arg1Of |
glycans,of |
R19229 |
T49127 |
T17734 |
arg1Of |
ID,PDB |
R19231 |
T77537 |
T45819 |
arg1Of |
shield,a |
R19265 |
T66921 |
T68204 |
arg2Of |
they,measured |
R19288 |
T96908 |
T30425 |
arg2Of |
based,are |
R19289 |
T26975 |
T72222 |
arg1Of |
network,an |
R193 |
T202 |
T199 |
arg2Of |
and,of |
R19300 |
T29223 |
T2696 |
arg1Of |
glycans,occluded |
R19325 |
T58264 |
T19959 |
arg2Of |
competent,remaining |
R19327 |
T35287 |
T63281 |
arg1Of |
virus,chimpanzee |
R19366 |
T68699 |
T41652 |
arg1Of |
presented,as |
R19392 |
T10175 |
T79176 |
arg1Of |
spectrometry,negative-ion |
R194 |
T201 |
T200 |
arg1Of |
SARS,coronavirus |
R19405 |
T23666 |
T67118 |
arg3Of |
),( |
R19443 |
T90266 |
T24380 |
arg1Of |
SARS,and |
R19445 |
T24421 |
T82839 |
arg1Of |
MERS,trimeric |
R19464 |
T1949 |
T77796 |
arg1Of |
diversity,the |
R195 |
T201 |
T202 |
arg1Of |
SARS,and |
R19513 |
T28812 |
T74425 |
arg1Of |
phenomenon,This |
R19514 |
T72703 |
T40990 |
arg1Of |
levels,of |
R19546 |
T27860 |
T89667 |
arg1Of |
events,characterized |
R196 |
T205 |
T202 |
arg2Of |
proteins,and |
R19617 |
T58264 |
T60128 |
arg1Of |
competent,functionally |
R19622 |
T36749 |
T90326 |
arg1Of |
co-localize,that |
R1966 |
T68640 |
T82313 |
arg1Of |
proteins,b |
R19683 |
T1670 |
T13557 |
arg2Of |
trimming,enhanced |
R19684 |
T84232 |
T1963 |
arg1Of |
"lectins47,48",implicated |
R197 |
T205 |
T203 |
arg1Of |
proteins,MERS |
R19725 |
T83973 |
T30617 |
arg2Of |
residues,between |
R19742 |
T55216 |
T19328 |
arg1Of |
We,suggest |
R198 |
T205 |
T204 |
arg1Of |
proteins,S |
R19805 |
T27945 |
T76460 |
arg1Of |
residues,amino-acid |
R19873 |
T99530 |
T31843 |
arg1Of |
analysis,glycan |
R199 |
T198 |
T206 |
arg1Of |
glycans,are |
R19904 |
T95590 |
T21392 |
arg2Of |
10.25345/C54705,[ |
R19912 |
T74716 |
T46731 |
arg2Of |
is,Given |
R19941 |
T66804 |
T9316 |
arg1Of |
surface,can |
R2 |
T4 |
T2 |
arg1Of |
shields,coronavirus |
R20 |
T23 |
T21 |
arg3Of |
),( |
R200 |
T208 |
T206 |
arg2Of |
distributed,are |
R20006 |
T14141 |
T38719 |
arg1Of |
presence,is |
R20022 |
T9018 |
T54890 |
arg2Of |
N-terminal,and |
R20046 |
T77842 |
T99218 |
arg1Of |
away,from |
R20067 |
T75213 |
T82633 |
arg1Of |
peptide,fusion |
R201 |
T208 |
T207 |
arg1Of |
distributed,heterogeneously |
R20103 |
T62341 |
T16494 |
arg2Of |
membrane,and |
R20104 |
T67026 |
T21495 |
arg1Of |
domains,were |
R20111 |
T47420 |
T65408 |
arg2Of |
number,dividing |
R20171 |
T17113 |
T24811 |
arg1Of |
proteins,S |
R202 |
T198 |
T208 |
arg2Of |
glycans,distributed |
R203 |
T208 |
T209 |
arg1Of |
distributed,and |
R20306 |
T28724 |
T35775 |
arg1Of |
efficacies,of |
R20308 |
T93961 |
T27490 |
arg2Of |
colored,are |
R20313 |
T54604 |
T67339 |
arg2Of |
viruses,classified |
R20318 |
T90583 |
T6621 |
arg1Of |
and,contribute |
R20355 |
T32345 |
T90583 |
arg2Of |
environment,and |
R20363 |
T80637 |
T20315 |
arg2Of |
S,"," |
R204 |
T212 |
T209 |
arg2Of |
form,and |
R20431 |
T10460 |
T76296 |
arg2Of |
and,were |
R20433 |
T43889 |
T51710 |
arg2Of |
GPC24,"," |
R20473 |
T76185 |
T35489 |
arg1Of |
b,S |
R205 |
T198 |
T210 |
arg1Of |
glycans,do |
R20505 |
T14682 |
T19094 |
arg1Of |
MERS,has |
R206 |
T212 |
T210 |
arg2Of |
form,do |
R20662 |
T30499 |
T86749 |
arg2Of |
accessibility,to |
R20667 |
T15651 |
T15044 |
arg1Of |
resolution,and |
R207 |
T212 |
T211 |
arg1Of |
form,not |
R20744 |
T52589 |
T75194 |
arg3Of |
),( |
R20757 |
T82481 |
T63639 |
arg1Of |
subunit,"," |
R20758 |
T32700 |
T66481 |
arg2Of |
is,Although |
R20779 |
T6629 |
T88912 |
arg2Of |
compositions,compared |
R20784 |
T76185 |
T7560 |
arg1Of |
b,11 and |
R208 |
T198 |
T212 |
arg1Of |
glycans,form |
R20859 |
T88896 |
T40836 |
arg1Of |
code,All |
R209 |
T217 |
T212 |
arg2Of |
shield,form |
R20962 |
T28935 |
T19712 |
arg1Of |
behaviour,the |
R20973 |
T82847 |
T85203 |
arg2Of |
performing,of |
R21 |
T28 |
T24 |
arg1Of |
are,coronaviruses |
R210 |
T217 |
T213 |
arg1Of |
shield,an |
R21035 |
T99013 |
T49752 |
arg2Of |
Fig. 4,( |
R21039 |
T1317 |
T1321 |
arg1Of |
is,to |
R21042 |
T63130 |
T21020 |
arg2Of |
surface,on |
R21082 |
T43304 |
T48004 |
arg1Of |
Same,in |
R211 |
T217 |
T214 |
arg1Of |
shield,efficacious |
R21108 |
T56201 |
T31567 |
arg2Of |
and,( |
R21139 |
T12305 |
T59830 |
arg1Of |
and,elevated |
R21190 |
T28685 |
T41253 |
arg1Of |
proteins,viral |
R212 |
T217 |
T215 |
arg1Of |
shield,high-density |
R21203 |
T83381 |
T99370 |
arg2Of |
glycosylation,exhibits |
R21230 |
T67621 |
T26015 |
arg1Of |
hand,one |
R21251 |
T10053 |
T20635 |
arg1Of |
speculate,to |
R21254 |
T46357 |
T1834 |
arg2Of |
differences,of |
R21261 |
T72195 |
T8288 |
arg1Of |
recognition,immune |
R21298 |
T94857 |
T43870 |
arg1Of |
Mapping,values. |
R213 |
T217 |
T216 |
arg1Of |
shield,global |
R21373 |
T24622 |
T98164 |
arg1Of |
codes,accession |
R214 |
T217 |
T218 |
arg1Of |
shield,which |
R21418 |
T91852 |
T19623 |
arg2Of |
amenability,to |
R21450 |
T15627 |
T32529 |
arg1Of |
nanobodies,could |
R2149 |
T28685 |
T25202 |
arg1Of |
proteins,class |
R215 |
T217 |
T219 |
arg1Of |
shield,would |
R21530 |
T49099 |
T69890 |
arg1Of |
domain,the |
R21540 |
T1932 |
T24463 |
arg2Of |
glycoproteins,of |
R21549 |
T89162 |
T78379 |
arg1Of |
as,"," |
R21565 |
T44453 |
T67014 |
arg1Of |
densities,glycan |
R216 |
T220 |
T219 |
arg2Of |
ensure,would |
R21612 |
T69286 |
T52989 |
arg1Of |
calculated,as |
R21639 |
T75003 |
T95449 |
arg1Of |
data,the |
R217 |
T217 |
T220 |
arg1Of |
shield,ensure |
R21723 |
T43286 |
T74010 |
arg1Of |
penetrate,easily |
R2173 |
T70323 |
T13755 |
arg1Of |
proteins,the |
R21732 |
T63281 |
T79382 |
arg2Of |
chimpanzee,and |
R21771 |
T21366 |
T33467 |
arg1Of |
sites,the |
R21784 |
T52603 |
T73339 |
arg2Of |
accompanying,and |
R218 |
T223 |
T220 |
arg2Of |
evasion,ensure |
R21820 |
T74879 |
T16401 |
arg2Of |
SARS,and |
R21828 |
T50771 |
T10053 |
arg1Of |
it,speculate |
R21857 |
T7775 |
T17162 |
arg2Of |
residues,colored |
R21880 |
T11435 |
T61578 |
arg2Of |
advantage,of |
R219 |
T223 |
T221 |
arg1Of |
evasion,efficient |
R21904 |
T91852 |
T39634 |
arg1Of |
amenability,its |
R21921 |
T13068 |
T25400 |
arg1Of |
functionality,of |
R21926 |
T36749 |
T32785 |
arg2Of |
co-localize,revealed |
R21940 |
T7370 |
T66013 |
arg2Of |
isolated,appear |
R21990 |
T54985 |
T68699 |
arg2Of |
proteins,presented |
R22 |
T24 |
T25 |
arg1Of |
coronaviruses,( |
R220 |
T223 |
T222 |
arg1Of |
evasion,immune |
R22049 |
T73178 |
T24147 |
arg2Of |
dark,and |
R2207 |
T36158 |
T62312 |
arg2Of |
BG505,( |
R22078 |
T91764 |
T1369 |
arg1Of |
shielding,by |
R221 |
T225 |
T226 |
arg1Of |
Coronaviruses,( |
R22100 |
T18180 |
T83144 |
arg1Of |
shielding,glycan |
R22124 |
T49949 |
T13339 |
arg1Of |
findings,the |
R22134 |
T8143 |
T17900 |
arg2Of |
chymotrypsin,plus |
R22147 |
T66936 |
T12725 |
arg2Of |
number,divided |
R22162 |
T76109 |
T65773 |
arg1Of |
undergoing,that |
R22163 |
T97323 |
T48816 |
arg1Of |
HIV-1,and |
R222 |
T227 |
T226 |
arg2Of |
CoVs,( |
R22266 |
T21366 |
T99523 |
arg1Of |
sites,N-linked |
R223 |
T228 |
T226 |
arg3Of |
),( |
R224 |
T225 |
T229 |
arg1Of |
Coronaviruses,are |
R22404 |
T56951 |
T84875 |
arg1Of |
we,generated |
R2241 |
T5616 |
T25906 |
arg1Of |
HAs,where |
R2243 |
T91020 |
T28189 |
arg2Of |
Man9GlcNAc2,; |
R22442 |
T28812 |
T88747 |
arg2Of |
phenomenon,observed |
R22461 |
T65162 |
T15804 |
arg2Of |
titres,elicit |
R22467 |
T55408 |
T6521 |
arg1Of |
ratio,a |
R22476 |
T79677 |
T96638 |
arg1Of |
maps,The |
R225 |
T231 |
T229 |
arg2Of |
pathogens,are |
R22503 |
T19388 |
T8292 |
arg2Of |
al.51,from |
R22521 |
T74546 |
T1601 |
arg2Of |
investigated,been |
R22544 |
T17681 |
T32770 |
arg1Of |
candidates,potential |
R22561 |
T68778 |
T11621 |
arg1Of |
it,offer |
R226 |
T231 |
T230 |
arg2Of |
pathogens,enveloped |
R2263 |
T40721 |
T2753 |
arg1Of |
panel,: |
R2265 |
T70745 |
T16791 |
arg2Of |
families,between |
R22666 |
T72680 |
T21071 |
arg1Of |
linked,to |
R22690 |
T97014 |
T88817 |
arg1Of |
response,the |
R22697 |
T69826 |
T25808 |
arg1Of |
glycoprotein,the |
R227 |
T231 |
T232 |
arg1Of |
pathogens,responsible |
R22713 |
T64497 |
T49283 |
arg1Of |
inventor,an |
R22723 |
T67337 |
T52338 |
arg2Of |
cluster,in |
R2273 |
T43156 |
T53375 |
arg1Of |
intervals,95 |
R22758 |
T20304 |
T50152 |
arg1Of |
differences,i.e. |
R22798 |
T9459 |
T30321 |
arg2Of |
application,on |
R228 |
T232 |
T233 |
arg1Of |
responsible,for |
R22808 |
T38040 |
T52822 |
arg2Of |
structure,visualize |
R22859 |
T54866 |
T20906 |
arg1Of |
glycans,N-linked |
R22862 |
T64096 |
T56477 |
arg1Of |
this,is |
R22864 |
T76651 |
T80310 |
arg1Of |
assortment,an |
R22881 |
T52475 |
T31921 |
arg1Of |
conservation,the |
R229 |
T236 |
T233 |
arg2Of |
disorders,for |
R2290 |
T30265 |
T9777 |
arg1Of |
reproduced,while |
R22945 |
T78120 |
T36313 |
arg1Of |
2D-variability,significant |
R22986 |
T37597 |
T2700 |
arg1Of |
data,the |
R22989 |
T41479 |
T52989 |
arg2Of |
number,as |
R23 |
T26 |
T25 |
arg2Of |
CoVs,( |
R230 |
T236 |
T234 |
arg1Of |
disorders,multiple |
R23030 |
T37852 |
T79086 |
arg3Of |
),( |
R23056 |
T17645 |
T77299 |
arg1Of |
sites,be |
R23058 |
T38777 |
T93386 |
arg1Of |
densities,glycan |
R23066 |
T6494 |
T57622 |
arg1Of |
sites,of |
R2307 |
T97136 |
T78671 |
arg1Of |
greater,far |
R23093 |
T5616 |
T39729 |
arg1Of |
HAs,influenza |
R231 |
T236 |
T235 |
arg1Of |
disorders,respiratory |
R23134 |
T93322 |
T75735 |
arg1Of |
context,a |
R23158 |
T68442 |
T32176 |
arg2Of |
domains,disordered |
R23171 |
T38606 |
T47548 |
arg1Of |
GPC,was |
R23177 |
T30435 |
T87545 |
arg1Of |
targeted,to |
R23178 |
T73114 |
T32700 |
arg1Of |
compare,is |
R23197 |
T31301 |
T2424 |
arg1Of |
and,ID |
R232 |
T236 |
T237 |
arg1Of |
disorders,of |
R23203 |
T71298 |
T49403 |
arg1Of |
glycoproteins,viral |
R23230 |
T36749 |
T5951 |
arg1Of |
co-localize,"," |
R23242 |
T89162 |
T9264 |
arg1Of |
as,reveal |
R23244 |
T68543 |
T71248 |
arg2Of |
glycoproteins,expressed |
R23260 |
T79346 |
T89551 |
arg2Of |
route,offer |
R23288 |
T36749 |
T66900 |
arg1Of |
co-localize,to |
R2329 |
T43357 |
T40990 |
arg2Of |
pressure,of |
R233 |
T239 |
T237 |
arg2Of |
severity,of |
R23301 |
T52371 |
T61083 |
arg1Of |
SARS,and |
R2333 |
T63488 |
T59510 |
arg3Of |
:,( |
R23393 |
T80500 |
T32298 |
arg1Of |
residues,the |
R234 |
T239 |
T238 |
arg1Of |
severity,varying |
R23417 |
T99047 |
T51798 |
arg2Of |
green,( |
R2347 |
T53051 |
T78843 |
arg1Of |
Env,SIV |
R23484 |
T13499 |
T90583 |
arg1Of |
differences,and |
R235 |
T239 |
T240 |
arg1Of |
severity,in |
R23537 |
T93961 |
T72784 |
arg1Of |
colored,according |
R23575 |
T21233 |
T50993 |
arg1Of |
published,previously |
R23595 |
T57983 |
T88640 |
arg1Of |
"shield54,55",glycan |
R236 |
T241 |
T240 |
arg2Of |
humans1,in |
R23692 |
T3337 |
T63380 |
arg1Of |
shield51,HIV-1 |
R237 |
T243 |
T242 |
arg1Of |
CoVs,Certain |
R23715 |
T50409 |
T70751 |
arg1Of |
available,upon |
R23718 |
T2686 |
T35212 |
arg2Of |
shield,in |
R23723 |
T91373 |
T23968 |
arg2Of |
and,exhibits |
R23725 |
T21366 |
T38634 |
arg2Of |
sites,of |
R23741 |
T62840 |
T86654 |
arg1Of |
end,that |
R23746 |
T93319 |
T91466 |
arg1Of |
domains,helix |
R23756 |
T89162 |
T17411 |
arg1Of |
as,a |
R23783 |
T17751 |
T37324 |
arg2Of |
abundance,against |
R23798 |
T61476 |
T61364 |
arg1Of |
residues,solvent-accessible |
R238 |
T243 |
T244 |
arg1Of |
CoVs,represent |
R2380 |
T70541 |
T91691 |
arg1Of |
and,how |
R23813 |
T55283 |
T12200 |
arg1Of |
showed51,recently |
R23849 |
T68539 |
T79414 |
arg1Of |
glycans,has |
R23889 |
T79412 |
T67524 |
arg1Of |
is,in |
R239 |
T247 |
T244 |
arg2Of |
threat,represent |
R23954 |
T21302 |
T67673 |
arg1Of |
shields,glycan |
R23985 |
T5164 |
T33108 |
arg1Of |
modelling,The |
R24 |
T27 |
T25 |
arg3Of |
),( |
R240 |
T247 |
T245 |
arg1Of |
threat,a |
R24020 |
T41479 |
T29326 |
arg1Of |
number,the |
R24076 |
T43478 |
T18984 |
arg2Of |
Glu-C,"," |
R241 |
T247 |
T246 |
arg1Of |
threat,significant |
R2412 |
T3262 |
T95276 |
arg1Of |
glycoproteins,spike |
R24149 |
T19203 |
T97210 |
arg1Of |
dataset,SARS |
R242 |
T247 |
T248 |
arg1Of |
threat,to |
R2421 |
T60437 |
T47078 |
arg2Of |
total,possesses |
R2422 |
T4769 |
T7211 |
arg2Of |
Fig. 4b,( |
R24220 |
T54076 |
T8587 |
arg1Of |
and,did |
R24262 |
T55061 |
T4581 |
arg1Of |
cells,II |
R24287 |
T12133 |
T34645 |
arg1Of |
5X58,"," |
R243 |
T251 |
T248 |
arg2Of |
health,to |
R24307 |
T17681 |
T15804 |
arg1Of |
candidates,elicit |
R24318 |
T94206 |
T10071 |
arg1Of |
showed,However |
R24334 |
T3264 |
T68472 |
modOf |
investigated,using |
R24335 |
T11708 |
T68521 |
arg1Of |
5X58,PDB |
R24338 |
T3894 |
T52698 |
arg1Of |
density,of |
R24376 |
T56105 |
T47548 |
arg2Of |
derived,was |
R244 |
T251 |
T249 |
arg1Of |
health,global |
R24475 |
T45261 |
T77923 |
arg1Of |
rather,than |
R245 |
T251 |
T250 |
arg1Of |
health,human |
R2450 |
T69491 |
T17336 |
arg1Of |
estimates,are |
R24535 |
T36749 |
T72350 |
modOf |
co-localize,consisting |
R24547 |
T15066 |
T45711 |
arg2Of |
LC-MS,( |
R24573 |
T19223 |
T67524 |
arg2Of |
comparison,in |
R24584 |
T18714 |
T59290 |
arg2Of |
shield,and |
R246 |
T244 |
T252 |
arg1Of |
represent,"," |
R24616 |
T2961 |
T92960 |
arg1Of |
had,Likewise |
R24628 |
T30499 |
T29305 |
modOf |
accessibility,to |
R24648 |
T35120 |
T25962 |
arg1Of |
subjected,to |
R24676 |
T24412 |
T69838 |
arg1Of |
limit,a |
R24690 |
T54609 |
T71605 |
arg2Of |
glycans,of |
R24697 |
T23755 |
T76280 |
arg1Of |
charts,pie |
R247 |
T244 |
T253 |
arg1Of |
represent,as |
R24751 |
T81231 |
T66257 |
arg1Of |
considered,in |
R248 |
T254 |
T253 |
arg2Of |
illustrated,as |
R24868 |
T93669 |
T73736 |
arg1Of |
compositions,glycan |
R249 |
T256 |
T254 |
arg1Of |
outbreaks,illustrated |
R24908 |
T90347 |
T57189 |
arg1Of |
proteins,S |
R24936 |
T46208 |
T70071 |
arg1Of |
spikes,CoV |
R24969 |
T14374 |
T39300 |
arg1Of |
graphs,afucosylated |
R25 |
T16 |
T28 |
arg1Of |
and,are |
R250 |
T256 |
T255 |
arg2Of |
outbreaks,by |
R25095 |
T99370 |
T41135 |
modOf |
exhibits,resulting |
R251 |
T256 |
T257 |
arg1Of |
outbreaks,of |
R25119 |
T68729 |
T30100 |
arg1Of |
volume,of |
R25157 |
T53051 |
T95730 |
arg1Of |
Env,( |
R25166 |
T39921 |
T32276 |
arg1Of |
patterns,molecular |
R25194 |
T19555 |
T65945 |
arg1Of |
importance,should |
R252 |
T262 |
T257 |
arg2Of |
coronavirus,of |
R25200 |
T38215 |
T76109 |
arg2Of |
rates,undergoing |
R25217 |
T94871 |
T40910 |
arg2Of |
shield,through |
R25260 |
T49864 |
T39300 |
arg2Of |
glycans,afucosylated |
R253 |
T262 |
T258 |
arg1Of |
coronavirus,severe |
R2531 |
T99373 |
T23895 |
arg1Of |
surfaces,white |
R254 |
T262 |
T259 |
arg1Of |
coronavirus,acute |
R25407 |
T9382 |
T94093 |
arg2Of |
S,and |
R25467 |
T35915 |
T74928 |
arg2Of |
structure,on |
R255 |
T262 |
T260 |
arg1Of |
coronavirus,respiratory |
R25556 |
T34506 |
T66750 |
arg2Of |
with,compared |
R25568 |
T63087 |
T60407 |
arg2Of |
S2,and |
R25583 |
T41923 |
T21879 |
arg1Of |
11,S |
R256 |
T262 |
T261 |
arg1Of |
coronavirus,syndrome |
R2562 |
T68800 |
T18761 |
arg1Of |
",",and |
R2567 |
T30499 |
T6499 |
arg2Of |
accessibility,hindered |
R25678 |
T81728 |
T3044 |
arg1Of |
compared,on |
R25685 |
T25884 |
T89591 |
arg2Of |
values,shown |
R2569 |
T51449 |
T47768 |
arg1Of |
proteins,class |
R257 |
T262 |
T263 |
arg1Of |
coronavirus,( |
R25741 |
T53375 |
T27417 |
arg1Of |
95,% |
R2577 |
T65868 |
T8410 |
arg2Of |
terms,in |
R258 |
T264 |
T263 |
arg2Of |
SARS-CoV,( |
R25821 |
T46654 |
T2508 |
arg2Of |
data,reported |
R25857 |
T72291 |
T29813 |
arg2Of |
colored,are |
R25874 |
T76185 |
T24421 |
arg1Of |
b,MERS |
R25896 |
T44303 |
T81866 |
arg2Of |
diversity,of |
R259 |
T265 |
T263 |
arg3Of |
),( |
R26 |
T30 |
T28 |
arg2Of |
pathogens,are |
R260 |
T262 |
T266 |
arg1Of |
coronavirus,in |
R26012 |
T18488 |
T36917 |
arg3Of |
],[ |
R26018 |
T27860 |
T18635 |
arg2Of |
events,repeated |
R261 |
T267 |
T266 |
arg2Of |
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R26107 |
T18790 |
T25102 |
arg1Of |
glycans,occluded |
R26115 |
T72393 |
T9777 |
arg2Of |
reprocessed,while |
R26118 |
T28404 |
T28338 |
arg2Of |
S.,on |
R26175 |
T94206 |
T88433 |
arg1Of |
showed,"," |
R262 |
T256 |
T268 |
arg1Of |
outbreaks,"," |
R263 |
T273 |
T268 |
arg2Of |
coronavirus,"," |
R26332 |
T18104 |
T72056 |
arg2Of |
terms,in |
R2636 |
T25304 |
T83245 |
arg1Of |
sequences,of |
R26362 |
T55156 |
T45284 |
arg2Of |
vulnerabilities,revealing |
R264 |
T270 |
T269 |
arg1Of |
East,Middle |
R26419 |
T95596 |
T82828 |
arg2Of |
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R26450 |
T25276 |
T97068 |
arg2Of |
glycans,of |
R265 |
T273 |
T270 |
arg1Of |
coronavirus,East |
R26511 |
T5302 |
T95555 |
arg1Of |
clusters,contribute |
R26558 |
T80637 |
T26336 |
arg1Of |
S,HKU1 |
R266 |
T273 |
T271 |
arg1Of |
coronavirus,respiratory |
R26617 |
T53506 |
T84481 |
arg1Of |
is,topically |
R26659 |
T2995 |
T83452 |
arg1Of |
study,this |
R267 |
T273 |
T272 |
arg1Of |
coronavirus,syndrome |
R26701 |
T94405 |
T32515 |
arg1Of |
model,structural |
R26733 |
T75209 |
T86558 |
arg2Of |
ectodomain52,of |
R268 |
T273 |
T274 |
arg1Of |
coronavirus,( |
R26875 |
T99830 |
T5062 |
arg2Of |
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R26878 |
T73121 |
T7627 |
arg2Of |
whereas,suggest |
R269 |
T275 |
T274 |
arg2Of |
MERS-CoV,( |
R26921 |
T3759 |
T66405 |
arg1Of |
S,MERS |
R26979 |
T77537 |
T76353 |
arg2Of |
shield,evolved |
R26983 |
T3894 |
T23766 |
arg2Of |
density,reach |
R26990 |
T65839 |
T13399 |
arg1Of |
and,the |
R26999 |
T87387 |
T52944 |
arg2Of |
and,of |
R27 |
T30 |
T29 |
arg1Of |
pathogens,zoonotic |
R270 |
T276 |
T274 |
arg3Of |
),( |
R27001 |
T30776 |
T79009 |
arg1Of |
S,SARS |
R27005 |
T74519 |
T95025 |
arg2Of |
glycans,of |
R27037 |
T25276 |
T12761 |
arg1Of |
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R27056 |
T3180 |
T36644 |
arg1Of |
analysis,ascertained |
R271 |
T273 |
T277 |
arg1Of |
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R272 |
T278 |
T277 |
arg2Of |
20123,in |
R27221 |
T81817 |
T32196 |
arg2Of |
order,In |
R27231 |
T75541 |
T89745 |
arg2Of |
coronaviruses,on |
R27248 |
T64497 |
T30321 |
arg1Of |
inventor,on |
R27251 |
T86628 |
T87992 |
arg1Of |
SARS,and |
R27276 |
T93400 |
T38026 |
arg1Of |
N-linked,2 |
R2728 |
T8652 |
T10460 |
arg2Of |
digested,and |
R273 |
T280 |
T279 |
arg1Of |
and,"," |
R27313 |
T65772 |
T12305 |
arg2Of |
abundance,and |
R2734 |
T93568 |
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//nextstrain.org/ncov,) |
R27361 |
T88747 |
T23330 |
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T277 |
T280 |
arg1Of |
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R2740 |
T41175 |
T26594 |
arg1Of |
strong”56,had |
R27405 |
T42803 |
T86408 |
arg2Of |
Fig. 3,in |
R27432 |
T59672 |
T60387 |
arg2Of |
considered,and |
R27443 |
T22579 |
T69920 |
arg1Of |
with,along |
R27480 |
T39562 |
T69974 |
arg1Of |
b,variability |
R275 |
T283 |
T280 |
arg2Of |
of,and |
R27517 |
T72195 |
T78182 |
arg1Of |
recognition,of |
R27546 |
T33045 |
T4038 |
arg1Of |
quantification,the |
R27562 |
T91138 |
T57479 |
arg2Of |
residues,of |
R27590 |
T70221 |
T54076 |
arg2Of |
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R276 |
T282 |
T281 |
arg1Of |
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R27660 |
T24985 |
T40354 |
arg2Of |
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R27680 |
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T71503 |
arg1Of |
proteins,are |
R277 |
T283 |
T282 |
arg1Of |
of,recently |
R27719 |
T29760 |
T28968 |
arg1Of |
repeat,heptad |
R27746 |
T67026 |
T89902 |
arg1Of |
domains,S1 |
R27785 |
T97014 |
T85837 |
arg1Of |
response,in |
R278 |
T273 |
T283 |
arg1Of |
coronavirus,of |
R27836 |
T40276 |
T29532 |
arg2Of |
found,can |
R2785 |
T9629 |
T60926 |
arg1Of |
and,were |
R279 |
T284 |
T283 |
arg2Of |
SARS-CoV-24,of |
R27910 |
T72051 |
T20968 |
arg2Of |
populations,and |
R27911 |
T33026 |
T45752 |
arg1Of |
glycans,were |
R27919 |
T24762 |
T43495 |
arg2Of |
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arg1Of |
densities,were |
R27975 |
T50573 |
T62342 |
arg1Of |
and,respectively |
R28 |
T30 |
T31 |
arg1Of |
pathogens,with |
R280 |
T313 |
T285 |
arg1Of |
is,Given |
R28008 |
T40780 |
T31749 |
arg1Of |
clusters,specific |
R28028 |
T70036 |
T3633 |
arg2Of |
pink,( |
R28079 |
T65417 |
T4164 |
arg2Of |
differ,may |
R281 |
T300 |
T285 |
arg2Of |
and,Given |
R28101 |
T60190 |
T33888 |
arg2Of |
Fig. 4c,( |
R28106 |
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T90429 |
arg1Of |
map,3.2-Å-resolution |
R282 |
T288 |
T286 |
arg1Of |
rates,their |
R28202 |
T99530 |
T71906 |
arg1Of |
analysis,N-linked |
R28264 |
T46492 |
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arg1Of |
and,be |
R283 |
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T287 |
arg1Of |
rates,mortality |
R28302 |
T11057 |
T44946 |
arg1Of |
analysis,and |
R28308 |
T5302 |
T66164 |
arg1Of |
clusters,mannose |
R28323 |
T65408 |
T21150 |
arg2Of |
dividing,by |
R28324 |
T67621 |
T30037 |
arg1Of |
hand,the |
R28363 |
T83312 |
T51718 |
arg1Of |
construct,( |
R28386 |
T46492 |
T99241 |
arg2Of |
and,with |
R284 |
T288 |
T289 |
arg1Of |
rates,"," |
R2842 |
T99530 |
T84409 |
arg1Of |
analysis,site-specific |
R28422 |
T36278 |
T63214 |
arg1Of |
S,SARS |
R28428 |
T15412 |
T38048 |
arg1Of |
domains,of |
R28443 |
T3483 |
T73202 |
arg1Of |
performed,To |
R28444 |
T5930 |
T81500 |
arg1Of |
infectivity,viral |
R28497 |
T40686 |
T79396 |
arg2Of |
produce,fail |
R285 |
T292 |
T289 |
arg2Of |
lack,"," |
R28527 |
T93319 |
T49934 |
arg1Of |
domains,which |
R28543 |
T44450 |
T36665 |
arg1Of |
coronaviruses,MERS |
R286 |
T292 |
T290 |
arg1Of |
lack,the |
R2862 |
T95304 |
T69427 |
arg3Of |
),( |
R28655 |
T89313 |
T11621 |
arg2Of |
much,offer |
R28693 |
T16112 |
T17730 |
arg1Of |
diversification,across |
R287 |
T292 |
T291 |
arg1Of |
lack,current |
R28704 |
T77822 |
T51235 |
arg2Of |
"glycoprotein22,58",upon |
R28712 |
T57392 |
T14064 |
arg1Of |
information,compositional |
R2872 |
T21302 |
T58960 |
arg1Of |
shields,Env |
R28786 |
T94035 |
T44190 |
arg1Of |
and,) |
R288 |
T292 |
T293 |
arg1Of |
lack,of |
R28846 |
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T24648 |
arg1Of |
is,that |
R289 |
T296 |
T293 |
arg2Of |
and,of |
R28915 |
T83454 |
T98572 |
arg2Of |
pathogens,of |
R28975 |
T3337 |
T69159 |
arg1Of |
shield51,glycan |
R29 |
T35 |
T31 |
arg2Of |
and,with |
R290 |
T295 |
T294 |
arg2Of |
treatments,targeted |
R291 |
T295 |
T296 |
arg1Of |
treatments,and |
R29152 |
T47095 |
T76573 |
arg1Of |
reduced,"," |
R29198 |
T39676 |
T22591 |
arg2Of |
"vivo57,58",in |
R292 |
T298 |
T296 |
arg2Of |
vaccines,and |
R29213 |
T38040 |
T6796 |
arg1Of |
structure,the |
R29286 |
T46492 |
T48178 |
arg1Of |
and,"," |
R293 |
T298 |
T297 |
arg1Of |
vaccines,licensed |
R29301 |
T52822 |
T91723 |
arg1Of |
visualize,to |
R29324 |
T12133 |
T35725 |
arg1Of |
5X58,PDB |
R2936 |
T17551 |
T33530 |
arg2Of |
shields,of |
R29363 |
T93961 |
T6760 |
arg1Of |
colored,"," |
R29370 |
T73192 |
T18164 |
arg1Of |
result,from |
R294 |
T300 |
T299 |
arg1Of |
and,"," |
R29477 |
T73192 |
T1176 |
arg2Of |
result,may |
R295 |
T289 |
T300 |
arg1Of |
",",and |
R296 |
T302 |
T300 |
arg2Of |
capacity,and |
R29627 |
T61005 |
T62312 |
arg1Of |
Env,( |
R29675 |
T82408 |
T43756 |
arg2Of |
paper,in |
R2968 |
T28847 |
T5339 |
arg2Of |
red,in |
R29694 |
T28812 |
T23330 |
arg1Of |
phenomenon,has |
R297 |
T302 |
T301 |
arg1Of |
capacity,their |
R29757 |
T10724 |
T29355 |
arg1Of |
leading,to |
R2979 |
T14194 |
T85081 |
arg2Of |
glycosylation,of |
R298 |
T304 |
T303 |
arg1Of |
transmit,to |
R29816 |
T4404 |
T10224 |
arg1Of |
and,MERS |
R29835 |
T12587 |
T66257 |
arg2Of |
environment,in |
R29839 |
T44453 |
T83252 |
arg1Of |
densities,shield |
R299 |
T302 |
T303 |
modOf |
capacity,to |
R29921 |
T95071 |
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arg2Of |
observed,was |
R2996 |
T16112 |
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arg1Of |
diversification,sequence |
R29975 |
T32151 |
T95784 |
arg1Of |
arises,that |
R29976 |
T36486 |
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arg2Of |
all,with |
R29978 |
T40276 |
T93684 |
arg2Of |
found,be |
R3 |
T4 |
T3 |
arg1Of |
shields,glycan |
R30 |
T34 |
T32 |
arg1Of |
rates,high |
R300 |
T304 |
T305 |
arg1Of |
transmit,between |
R3001 |
T29000 |
T79412 |
arg2Of |
sparser,is |
R30047 |
T28741 |
T76185 |
arg1Of |
mapping,b |
R30085 |
T63997 |
T41377 |
arg2Of |
example,for |
R301 |
T306 |
T305 |
arg2Of |
humans,between |
R30100 |
T15412 |
T76133 |
arg1Of |
domains,the |
R30154 |
T66339 |
T16555 |
arg3Of |
incapable,render |
R30159 |
T32151 |
T86749 |
arg1Of |
arises,to |
R30163 |
T16458 |
T63581 |
arg1Of |
dataset52,2P |
R30172 |
T33026 |
T44762 |
arg2Of |
glycans,labelled |
R30180 |
T76860 |
T12192 |
arg2Of |
glycans,presented |
R302 |
T285 |
T307 |
arg1Of |
Given,and |
R303 |
T308 |
T307 |
arg2Of |
across,and |
R30304 |
T55016 |
T30445 |
arg2Of |
with,compared |
R30322 |
T31709 |
T36472 |
arg1Of |
structure,the |
R3033 |
T26975 |
T64977 |
arg1Of |
network,of |
R30349 |
T68442 |
T34000 |
arg1Of |
domains,receptor-binding |
R30362 |
T67419 |
T66971 |
arg1Of |
availability,Data |
R30385 |
T6494 |
T65600 |
arg1Of |
sites,receptor-binding |
R304 |
T313 |
T308 |
arg1Of |
is,across |
R30400 |
T69312 |
T85163 |
arg1Of |
and,"," |
R30471 |
T1374 |
T1375 |
arg1Of |
study,adds |
R30496 |
T27945 |
T75621 |
arg1Of |
residues,interacting |
R305 |
T310 |
T308 |
arg2Of |
"barriers5,6",across |
R30503 |
T19203 |
T69700 |
arg1Of |
dataset,the |
R30561 |
T84994 |
T28395 |
arg2Of |
processing,observed |
R30596 |
T12587 |
T94028 |
arg1Of |
environment,which |
R306 |
T310 |
T309 |
arg1Of |
"barriers5,6",species |
R30633 |
T81925 |
T15094 |
arg1Of |
proteins,( |
R30657 |
T74716 |
T1822 |
arg1Of |
is,is |
R307 |
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T311 |
arg1Of |
is,"," |
R30712 |
T10045 |
T39650 |
arg2Of |
known,( |
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T312 |
T313 |
arg1Of |
there,is |
R30852 |
T4934 |
T42560 |
arg1Of |
responses,immune |
R309 |
T316 |
T313 |
arg2Of |
need,is |
R3093 |
T88004 |
T70835 |
arg1Of |
mutants,these |
R30930 |
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T74809 |
arg2Of |
available,is |
R30949 |
T96908 |
T54010 |
arg1Of |
based,on |
R30995 |
T10009 |
T62759 |
arg1Of |
studied,and |
R30996 |
T16085 |
T2441 |
arg2Of |
resolutions,at |
R31 |
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T33 |
arg1Of |
rates,fatality |
R310 |
T316 |
T314 |
arg1Of |
need,an |
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T79807 |
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arg2Of |
Fig. 3a,( |
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T99472 |
T4874 |
arg1Of |
constraints,greater |
R311 |
T316 |
T315 |
arg1Of |
need,urgent |
R31129 |
T55408 |
T8471 |
arg2Of |
ratio,calculated |
R31141 |
T77922 |
T36749 |
arg1Of |
glycans,co-localize |
R31178 |
T59031 |
T50530 |
arg1Of |
glycans,lack |
R312 |
T316 |
T317 |
arg1Of |
need,for |
R31235 |
T2487 |
T10413 |
arg2Of |
auto-thresholding,and |
R31243 |
T34676 |
T27307 |
arg2Of |
be,may |
R31252 |
T70902 |
T80278 |
arg1Of |
plays,in |
R31263 |
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T20053 |
arg1Of |
and,"," |
R31284 |
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arg1Of |
a,) |
R313 |
T319 |
T317 |
arg2Of |
countermeasures,for |
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T17100 |
arg1Of |
sites,with |
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T62826 |
T75452 |
arg2Of |
Fig. 2a,( |
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T317 |
arg3Of |
combat,for |
R3140 |
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arg2Of |
densities,investigated |
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arg1Of |
considered,in |
R315 |
T319 |
T318 |
arg1Of |
countermeasures,effective |
R31526 |
T2204 |
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arg1Of |
sites,of |
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T60433 |
arg2Of |
approach,calculated |
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arg2Of |
Env49,"," |
R316 |
T321 |
T320 |
arg1Of |
combat,to |
R31607 |
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T53325 |
arg1Of |
target,of |
R31614 |
T1949 |
T35196 |
arg2Of |
diversity,shown |
R31615 |
T77922 |
T49774 |
arg1Of |
glycans,oligomannose-type |
R31642 |
T99472 |
T34520 |
arg1Of |
constraints,( |
R31693 |
T70745 |
T15216 |
arg1Of |
families,viral |
R31695 |
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T55384 |
arg1Of |
quantities,with |
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T319 |
T321 |
arg1Of |
countermeasures,combat |
R31717 |
T46492 |
T59110 |
arg1Of |
and,which |
R31766 |
T40473 |
T20923 |
arg1Of |
according,to |
R318 |
T323 |
T321 |
arg2Of |
pathogens,combat |
R31827 |
T46492 |
T61432 |
arg1Of |
and,are |
R31883 |
T58379 |
T7334 |
arg1Of |
target,"," |
R319 |
T323 |
T322 |
arg1Of |
pathogens,these |
R31934 |
T28342 |
T24257 |
arg1Of |
and,their |
R31936 |
T80158 |
T18287 |
arg1Of |
SI,Fig. 2 |
R32 |
T34 |
T35 |
arg1Of |
rates,and |
R320 |
T328 |
T324 |
arg1Of |
focus,Ongoing |
R32000 |
T70981 |
T19767 |
arg1Of |
due,likely |
R32001 |
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T14483 |
arg1Of |
shield,the |
R32032 |
T23375 |
T30414 |
arg3Of |
),( |
R32039 |
T17551 |
T16798 |
arg1Of |
shields,of |
R32077 |
T14190 |
T99213 |
arg1Of |
analysis,variability |
R321 |
T328 |
T325 |
arg1Of |
focus,vaccine |
R32137 |
T16085 |
T86172 |
arg1Of |
resolutions,necessary |
R32141 |
T3894 |
T96858 |
arg1Of |
density,the |
R322 |
T328 |
T326 |
arg1Of |
focus,development |
R32231 |
T82055 |
T99485 |
arg1Of |
as,such |
R32297 |
T75554 |
T16555 |
arg1Of |
spikes,render |
R323 |
T328 |
T327 |
arg1Of |
focus,efforts |
R32364 |
T82951 |
T81018 |
arg2Of |
hallmark,are |
R324 |
T328 |
T329 |
arg1Of |
focus,on |
R32448 |
T97839 |
T87216 |
arg1Of |
note,It |
R32451 |
T64807 |
T1909 |
arg2Of |
hemagglutinin,"," |
R32455 |
T49302 |
T57712 |
arg1Of |
server,MassIVE |
R3248 |
T64331 |
T46802 |
arg1Of |
ratios,dN/dS |
R32496 |
T17751 |
T83132 |
arg1Of |
abundance,oligomannose |
R325 |
T335 |
T329 |
arg2Of |
proteins,on |
R32590 |
T43748 |
T3599 |
arg1Of |
structure,atomic |
R32592 |
T11220 |
T73691 |
arg2Of |
dynamics,and |
R326 |
T335 |
T330 |
arg1Of |
proteins,the |
R32632 |
T12305 |
T26594 |
arg2Of |
and,had |
R327 |
T335 |
T331 |
arg1Of |
proteins,spike |
R32729 |
T69246 |
T66095 |
arg1Of |
domain,the |
R328 |
T335 |
T332 |
arg1Of |
proteins,( |
R3285 |
T3180 |
T73246 |
arg2Of |
analysis,by |
R3287 |
T69246 |
T52990 |
arg1Of |
domain,S2 |
R329 |
T333 |
T332 |
arg2Of |
S,( |
R32904 |
T69826 |
T57750 |
arg2Of |
glycoprotein,of |
R32959 |
T84481 |
T92680 |
arg1Of |
topically,More |
R33 |
T37 |
T35 |
arg2Of |
potential,and |
R330 |
T334 |
T332 |
arg3Of |
),( |
R33015 |
T14141 |
T95025 |
arg1Of |
presence,of |
R33016 |
T2508 |
T43756 |
arg1Of |
reported,in |
R33056 |
T77922 |
T72350 |
arg1Of |
glycans,consisting |
R33083 |
T37715 |
T31650 |
arg1Of |
et,Berndsen |
R331 |
T335 |
T336 |
arg1Of |
proteins,that |
R33103 |
T38040 |
T51236 |
arg1Of |
structure,of |
R33105 |
T41479 |
T1834 |
arg1Of |
number,of |
R33143 |
T5302 |
T65310 |
arg1Of |
clusters,that |
R33151 |
T90138 |
T79086 |
arg1Of |
SARS,( |
R332 |
T335 |
T337 |
arg1Of |
proteins,protrude |
R3329 |
T57392 |
T40276 |
arg2Of |
information,found |
R333 |
T337 |
T338 |
arg1Of |
protrude,from |
R33306 |
T94093 |
T63910 |
arg1Of |
and,( |
R33310 |
T26306 |
T89403 |
arg1Of |
we,used |
R3336 |
T74546 |
T60387 |
arg1Of |
investigated,and |
R3337 |
T26380 |
T92544 |
arg1Of |
value,of |
R33373 |
T78348 |
T49839 |
arg2Of |
Fig. 5,( |
R334 |
T341 |
T338 |
arg2Of |
envelope,from |
R33403 |
T81512 |
T33229 |
arg1Of |
18,being |
R33406 |
T35201 |
T47385 |
arg1Of |
reflected,further |
R33443 |
T45372 |
T66305 |
arg2Of |
tempting,is |
R33448 |
T40164 |
T5230 |
arg2Of |
materials,presented |
R335 |
T341 |
T339 |
arg1Of |
envelope,the |
R33550 |
T79346 |
T99997 |
arg1Of |
route,to |
R33554 |
T64543 |
T98572 |
arg1Of |
zoonosis,of |
R33577 |
T49949 |
T20416 |
arg2Of |
findings,support |
R33595 |
T97427 |
T11359 |
arg1Of |
and,consist |
R336 |
T341 |
T340 |
arg1Of |
envelope,viral |
R33651 |
T39562 |
T5294 |
arg2Of |
b,: |
R33652 |
T7451 |
T93687 |
arg1Of |
",","," |
R33694 |
T83803 |
T3618 |
arg1Of |
M9,to |
R337 |
T337 |
T342 |
arg1Of |
protrude,and |
R33706 |
T39921 |
T72183 |
arg1Of |
patterns,pathogen-associated |
R33721 |
T48779 |
T3547 |
arg1Of |
indicated,"," |
R33747 |
T46887 |
T52910 |
arg2Of |
sites,and |
R33779 |
T40590 |
T30498 |
arg1Of |
area,protein |
R338 |
T343 |
T342 |
arg2Of |
constitute,and |
R33832 |
T24905 |
T58957 |
arg1Of |
area,surface |
R339 |
T335 |
T343 |
arg1Of |
proteins,constitute |
R33985 |
T26472 |
T22974 |
arg1Of |
subunit,S2 |
R33999 |
T14860 |
T75452 |
arg3Of |
),( |
R34 |
T37 |
T36 |
arg1Of |
potential,pandemic |
R340 |
T346 |
T343 |
arg2Of |
target,constitute |
R34019 |
T17113 |
T93138 |
arg2Of |
proteins,digested |
R34068 |
T81576 |
T15304 |
arg2Of |
underprocessed,were |
R341 |
T346 |
T344 |
arg1Of |
target,the |
R34126 |
T61867 |
T97427 |
arg1Of |
GPC,and |
R34127 |
T93291 |
T40028 |
arg1Of |
filtering,low-pass |
R34151 |
T29035 |
T30617 |
arg1Of |
Comparison,between |
R34175 |
T24421 |
T8210 |
arg1Of |
MERS,a |
R34180 |
T30499 |
T19511 |
arg1Of |
accessibility,the |
R34184 |
T53545 |
T94530 |
arg1Of |
enzymes,processing |
R3419 |
T85948 |
T93438 |
arg2Of |
perturbing,without |
R342 |
T346 |
T345 |
arg1Of |
target,main |
R34223 |
T27616 |
T47642 |
arg2Of |
Fig. 5,( |
R34224 |
T16555 |
T68142 |
arg2Of |
render,would |
R34277 |
T33026 |
T60951 |
arg1Of |
glycans,that |
R34279 |
T59603 |
T86795 |
arg1Of |
values,dN/dS |
R34285 |
T23338 |
T95596 |
arg2Of |
HA50,and |
R3429 |
T11435 |
T47037 |
arg1Of |
advantage,protective |
R343 |
T346 |
T347 |
arg1Of |
target,of |
R3433 |
T94405 |
T45778 |
arg2Of |
model,onto |
R34352 |
T51710 |
T95596 |
arg1Of |
",",and |
R34359 |
T44348 |
T84029 |
arg2Of |
MERS,Purified |
R34390 |
T39713 |
T81231 |
arg2Of |
they,considered |
R344 |
T348 |
T347 |
arg2Of |
neutralizing,of |
R34457 |
T28784 |
T68425 |
arg1Of |
5X59,PDB |
R345 |
T349 |
T348 |
arg2Of |
"antibodies7,8",neutralizing |
R34518 |
T48265 |
T51798 |
arg1Of |
quantities,( |
R34568 |
T69499 |
T65163 |
arg1Of |
Analysis,of |
R34571 |
T9415 |
T91463 |
arg1Of |
variability,coming |
R34585 |
T35201 |
T57766 |
arg1Of |
reflected,"," |
R346 |
T353 |
T350 |
arg1Of |
proteins,These |
R34633 |
T41472 |
T24446 |
arg2Of |
glycosylation,of |
R34682 |
T68424 |
T79801 |
arg1Of |
We,ascertain |
R347 |
T353 |
T351 |
arg1Of |
proteins,trimeric |
R34726 |
T72037 |
T19959 |
arg1Of |
most,remaining |
R3479 |
T54092 |
T2107 |
arg2Of |
right,to |
R348 |
T353 |
T352 |
arg1Of |
proteins,S |
R34840 |
T71146 |
T5339 |
arg1Of |
colored,in |
R34853 |
T86863 |
T73114 |
arg2Of |
viruses,compare |
R34860 |
T25542 |
T55713 |
arg1Of |
coverage,of |
R34869 |
T37597 |
T19064 |
arg1Of |
data,HIV |
R34883 |
T10053 |
T55394 |
arg1Of |
speculate,"," |
R34892 |
T9637 |
T81770 |
arg1Of |
and,; |
R349 |
T353 |
T354 |
arg1Of |
proteins,mediate |
R34905 |
T4586 |
T35591 |
arg2Of |
0.31,of |
R34919 |
T1949 |
T70132 |
arg1Of |
diversity,amino-acid |
R34991 |
T44352 |
T3158 |
arg1Of |
shielding,glycan |
R34998 |
T74519 |
T70586 |
arg1Of |
glycans,oligomannose-type |
R35 |
T39 |
T38 |
arg1Of |
development,Vaccine |
R350 |
T356 |
T354 |
arg2Of |
entry,mediate |
R35005 |
T19047 |
T77710 |
arg1Of |
analysis,Fig. |
R35026 |
T51996 |
T60493 |
modOf |
calculated,using |
R35049 |
T42677 |
T43754 |
arg1Of |
distribution,of |
R35059 |
T87308 |
T48330 |
arg1Of |
all-encompassing,nearly |
R35082 |
T82870 |
T78718 |
arg1Of |
protein,S |
R351 |
T356 |
T355 |
arg1Of |
entry,host-cell |
R3511 |
T19879 |
T80173 |
arg1Of |
",","," |
R35116 |
T77577 |
T22099 |
arg2Of |
observed,are |
R35155 |
T92070 |
T31354 |
arg1Of |
proteins,S |
R352 |
T354 |
T357 |
arg1Of |
mediate,with |
R35270 |
T95495 |
T28888 |
arg1Of |
grey,light |
R353 |
T362 |
T357 |
arg2Of |
subunits,with |
R35366 |
T66804 |
T90175 |
arg1Of |
surface,protein |
R35368 |
T75995 |
T94718 |
arg2Of |
observed,as |
R35379 |
T95927 |
T91547 |
arg1Of |
fucosylation,core |
R354 |
T362 |
T358 |
arg1Of |
subunits,the |
R35402 |
T11621 |
T26368 |
arg2Of |
offer,since |
R35456 |
T72666 |
T75361 |
arg1Of |
approach,was |
R35471 |
T65942 |
T28802 |
arg1Of |
Fabs51,base-specific |
R35479 |
T32151 |
T60015 |
arg2Of |
arises,hypothesized |
R355 |
T362 |
T359 |
arg1Of |
subunits,S1 |
R356 |
T359 |
T360 |
arg1Of |
S1,and |
R35607 |
T93380 |
T1991 |
arg1Of |
and,"," |
R35610 |
T13277 |
T38634 |
arg1Of |
all,of |
R3563 |
T54786 |
T50741 |
arg1Of |
"research22,60",vaccine |
R35674 |
T41135 |
T24089 |
modOf |
resulting,to |
R35680 |
T93669 |
T41991 |
arg1Of |
compositions,experimentally |
R357 |
T361 |
T360 |
arg2Of |
S2,and |
R35700 |
T94857 |
T80900 |
arg1Of |
Mapping,mean |
R35754 |
T79227 |
T13208 |
arg2Of |
Asn166,"," |
R35795 |
T43286 |
T32529 |
arg2Of |
penetrate,could |
R35799 |
T61369 |
T78947 |
arg1Of |
ratio,relative |
R358 |
T362 |
T361 |
arg1Of |
subunits,S2 |
R35841 |
T77577 |
T53841 |
arg1Of |
observed,while |
R359 |
T362 |
T363 |
arg1Of |
subunits,responsible |
R35928 |
T38470 |
T82290 |
arg2Of |
SARS,and |
R35964 |
T71106 |
T70752 |
arg2Of |
addition,In |
R36 |
T39 |
T40 |
arg1Of |
development,focuses |
R360 |
T363 |
T364 |
arg1Of |
responsible,for |
R36002 |
T85214 |
T73775 |
arg2Of |
and,of |
R36011 |
T17681 |
T53332 |
arg1Of |
candidates,able |
R36037 |
T49843 |
T8574 |
arg2Of |
hotspots,highlighted |
R3609 |
T40721 |
T4786 |
arg1Of |
panel,Middle |
R361 |
T370 |
T364 |
arg2Of |
and,for |
R36115 |
T54724 |
T45778 |
arg1Of |
mapped,onto |
R36125 |
T27706 |
T12646 |
arg1Of |
and,of |
R36158 |
T80500 |
T2961 |
arg1Of |
residues,had |
R3618 |
T73857 |
T52453 |
arg1Of |
convolved,with |
R3619 |
T88367 |
T55071 |
arg2Of |
levels,revealed |
R362 |
T365 |
T366 |
arg1Of |
binding,to |
R36201 |
T5495 |
T12106 |
arg1Of |
mutations,N236A |
R3623 |
T43073 |
T72481 |
arg1Of |
overlaid,peptide-only |
R36276 |
T45067 |
T38496 |
arg1Of |
glycans,shield |
R363 |
T369 |
T366 |
arg2Of |
receptor,to |
R36325 |
T64129 |
T13582 |
arg1Of |
MERS,and |
R364 |
T369 |
T367 |
arg1Of |
receptor,the |
R36430 |
T48779 |
T34630 |
arg2Of |
indicated,are |
R3644 |
T61150 |
T75194 |
arg2Of |
A1,( |
R36469 |
T12886 |
T64492 |
arg1Of |
N155A,"," |
R365 |
T369 |
T368 |
arg1Of |
receptor,host-cell |
R366 |
T365 |
T370 |
arg1Of |
binding,and |
R36620 |
T46357 |
T91746 |
arg1Of |
differences,pairwise |
R36627 |
T70460 |
T12473 |
arg2Of |
clustering,reduced |
R367 |
T371 |
T370 |
arg2Of |
facilitating,and |
R36721 |
T32352 |
T7289 |
arg3Of |
),( |
R36741 |
T17810 |
T23843 |
arg2Of |
responses,of |
R36773 |
T65168 |
T77097 |
arg2Of |
content,to |
R368 |
T373 |
T371 |
arg2Of |
fusion,facilitating |
R36808 |
T99370 |
T34922 |
arg1Of |
exhibits,"," |
R36824 |
T66804 |
T95551 |
arg2Of |
surface,buried |
R36844 |
T87940 |
T87134 |
arg2Of |
and,in |
R36848 |
T57983 |
T16903 |
arg2Of |
"shield54,55",of |
R36854 |
T29035 |
T92542 |
arg1Of |
Comparison,of |
R36891 |
T20594 |
T39672 |
arg1Of |
residues,amino-acid |
R369 |
T373 |
T372 |
arg1Of |
fusion,membrane |
R36912 |
T74921 |
T20774 |
arg1Of |
panel,Right |
R36961 |
T93591 |
T35302 |
arg2Of |
elevated,was |
R36990 |
T43156 |
T94719 |
arg1Of |
intervals,density |
R37 |
T40 |
T41 |
arg1Of |
focuses,on |
R370 |
T362 |
T374 |
arg1Of |
subunits,"," |
R37036 |
T34676 |
T64649 |
arg1Of |
be,In |
R37081 |
T25102 |
T46892 |
arg2Of |
occluded,are |
R37083 |
T92849 |
T90969 |
arg2Of |
residues,Buried |
R371 |
T375 |
T374 |
arg2Of |
respectively9–11,"," |
R3711 |
T79028 |
T29305 |
arg1Of |
access,to |
R37191 |
T67976 |
T37828 |
arg1Of |
glycome,the |
R372 |
T377 |
T376 |
arg1Of |
S,MERS |
R37258 |
T62735 |
T33520 |
arg2Of |
and,of |
R373 |
T377 |
T378 |
arg1Of |
S,binds |
R37399 |
T5230 |
T27038 |
arg1Of |
presented,"," |
R374 |
T378 |
T379 |
arg1Of |
binds,to |
R37429 |
T93669 |
T17443 |
arg1Of |
compositions,( |
R37437 |
T87051 |
T66339 |
arg1Of |
it,incapable |
R37446 |
T49759 |
T13436 |
arg1Of |
are,but |
R37452 |
T36034 |
T78152 |
arg1Of |
epitopes,immunogenic |
R375 |
T380 |
T379 |
arg2Of |
dipeptidyl-peptidase,to |
R37505 |
T13185 |
T50573 |
arg1Of |
n = 70,and |
R37534 |
T39465 |
T63649 |
arg1Of |
“shields”,of |
R37559 |
T13006 |
T68681 |
arg2Of |
sites,knock |
R37586 |
T77537 |
T85678 |
arg1Of |
shield,dense |
R37591 |
T67259 |
T56277 |
arg2Of |
on,depending |
R376 |
T380 |
T381 |
arg1Of |
dipeptidyl-peptidase,4 |
R37616 |
T64664 |
T93568 |
arg1Of |
revealed,//nextstrain.org/ncov |
R37654 |
T98451 |
T54724 |
arg2Of |
diversities,mapped |
R377 |
T380 |
T382 |
arg1Of |
dipeptidyl-peptidase,( |
R378 |
T383 |
T382 |
arg2Of |
DPP4,( |
R3781 |
T33615 |
T87940 |
arg1Of |
SARS,and |
R37843 |
T18714 |
T10675 |
arg1Of |
shield,glycan |
R37889 |
T73121 |
T31775 |
arg1Of |
whereas,"," |
R379 |
T384 |
T382 |
arg3Of |
),( |
R37988 |
T49812 |
T18669 |
arg1Of |
particles,virus-like |
R38 |
T44 |
T41 |
arg2Of |
target,on |
R380 |
T380 |
T385 |
arg1Of |
dipeptidyl-peptidase,12 |
R38048 |
T43420 |
T18725 |
arg1Of |
and,"," |
R38059 |
T71311 |
T20923 |
arg2Of |
number,to |
R38078 |
T97769 |
T37387 |
arg2Of |
nextstrain61,from |
R38082 |
T1963 |
T32823 |
arg1Of |
implicated,also |
R381 |
T378 |
T386 |
arg1Of |
binds,"," |
R38109 |
T13438 |
T3618 |
arg2Of |
M5,to |
R38141 |
T60681 |
T9810 |
arg1Of |
diversification,Sequence |
R38169 |
T69877 |
T70780 |
arg1Of |
trimers,in |
R382 |
T378 |
T387 |
arg1Of |
binds,whereas |
R38262 |
T23755 |
T57945 |
arg1Of |
charts,summarise |
R38291 |
T87051 |
T16555 |
arg2Of |
it,render |
R383 |
T392 |
T387 |
arg2Of |
utilize,whereas |
R38316 |
T77800 |
T78537 |
arg1Of |
analysis,of |
R38335 |
T84041 |
T37933 |
arg1Of |
Fig. 6,and |
R3838 |
T27706 |
T36859 |
arg2Of |
and,of |
R384 |
T389 |
T388 |
arg1Of |
S13,SARS |
R38415 |
T40590 |
T87161 |
arg1Of |
area,surface |
R38420 |
T15044 |
T97054 |
arg1Of |
and,which |
R38434 |
T62928 |
T13983 |
arg1Of |
glycans,arise |
R3845 |
T31999 |
T60493 |
arg2Of |
and,using |
R38468 |
T24930 |
T61347 |
arg1Of |
S,SARS |
R385 |
T389 |
T390 |
arg1Of |
S13,and |
R38518 |
T80657 |
T49427 |
arg1Of |
protein,fusion |
R38554 |
T48779 |
T13712 |
arg1Of |
indicated,respectively |
R3858 |
T18984 |
T82693 |
arg1Of |
",",and |
R3859 |
T48129 |
T41593 |
arg2Of |
IgG,of |
R386 |
T391 |
T390 |
arg2Of |
"SARS-CoV-214,15",and |
R38610 |
T21412 |
T37324 |
arg1Of |
plotted,against |
R38629 |
T77097 |
T72784 |
arg2Of |
to,according |
R38632 |
T92849 |
T78244 |
arg1Of |
residues,on |
R38659 |
T89162 |
T30415 |
arg1Of |
as,compare |
R38678 |
T77710 |
T43639 |
arg1Of |
Fig.,5 |
R387 |
T390 |
T392 |
arg1Of |
and,utilize |
R38765 |
T30294 |
T57548 |
arg1Of |
densities,Glycan |
R38781 |
T56088 |
T92957 |
arg1Of |
Proteins,Coronavirus |
R388 |
T394 |
T392 |
arg2Of |
enzyme,utilize |
R38837 |
T32345 |
T48983 |
arg1Of |
environment,immune |
R38877 |
T34676 |
T78686 |
arg1Of |
be,"," |
R389 |
T394 |
T393 |
arg1Of |
enzyme,angiotensin-converting |
R38925 |
T18714 |
T87196 |
arg1Of |
shield,"," |
R38960 |
T70981 |
T56477 |
arg2Of |
due,is |
R39 |
T44 |
T42 |
arg1Of |
target,the |
R390 |
T394 |
T395 |
arg1Of |
enzyme,2 |
R39024 |
T71248 |
T33142 |
arg1Of |
expressed,as |
R39068 |
T77577 |
T14875 |
arg1Of |
observed,"," |
R391 |
T394 |
T396 |
arg1Of |
enzyme,( |
R3910 |
T79801 |
T45093 |
arg1Of |
ascertain,to |
R39154 |
T40508 |
T85817 |
arg1Of |
sites,receptor-binding |
R39194 |
T14374 |
T64768 |
arg1Of |
graphs,represent |
R39195 |
T28784 |
T78652 |
arg2Of |
5X59,( |
R392 |
T397 |
T396 |
arg2Of |
ACE2,( |
R39207 |
T53545 |
T56293 |
arg2Of |
enzymes,of |
R39260 |
T75718 |
T58946 |
arg1Of |
mapping,Structure-based |
R393 |
T398 |
T396 |
arg3Of |
),( |
R39310 |
T40406 |
T5519 |
arg2Of |
and,as |
R39332 |
T84994 |
T58559 |
arg2Of |
processing,to |
R39357 |
T9637 |
T97993 |
arg2Of |
and,for |
R39369 |
T72197 |
T73801 |
arg1Of |
glycoproteins,these |
R39372 |
T43288 |
T27968 |
arg2Of |
resides,for |
R39386 |
T65417 |
T91973 |
arg2Of |
differ,but |
R394 |
T392 |
T399 |
arg1Of |
utilize,as |
R395 |
T403 |
T399 |
arg2Of |
receptor,as |
R39529 |
T76353 |
T32869 |
arg1Of |
evolved,that |
R39589 |
T98975 |
T51805 |
arg1Of |
majority,the |
R396 |
T403 |
T400 |
arg1Of |
receptor,a |
R39682 |
T82683 |
T54231 |
arg2Of |
deposited,been |
R39691 |
T12725 |
T53426 |
arg1Of |
divided,as |
R397 |
T403 |
T401 |
arg1Of |
receptor,host |
R39709 |
T81231 |
T83434 |
arg2Of |
considered,be |
R39712 |
T12013 |
T79243 |
arg2Of |
HKU1,and |
R39745 |
T80993 |
T91843 |
arg2Of |
mutagenesis,performed |
R39760 |
T72703 |
T44486 |
arg2Of |
levels,in |
R398 |
T403 |
T402 |
arg1Of |
receptor,cellular |
R3981 |
T3483 |
T60967 |
arg1Of |
performed,"," |
R39812 |
T54925 |
T25318 |
arg1Of |
analyses,of |
R39821 |
T23904 |
T10927 |
arg1Of |
PNGs,existing |
R39844 |
T92110 |
T12304 |
arg1Of |
glycans,and |
R39856 |
T10053 |
T71408 |
arg1Of |
speculate,"," |
R39868 |
T28685 |
T16798 |
arg2Of |
proteins,of |
R39879 |
T74217 |
T58888 |
arg2Of |
and,including |
R399 |
T406 |
T404 |
arg1Of |
proteins,CoV |
R3992 |
T75213 |
T12698 |
arg1Of |
peptide,the |
R4 |
T0 |
T5 |
arg1Of |
Vulnerabilities,despite |
R40 |
T44 |
T43 |
arg1Of |
target,principal |
R400 |
T406 |
T405 |
arg1Of |
proteins,S |
R40020 |
T97014 |
T22448 |
arg1Of |
response,immune |
R401 |
T406 |
T407 |
arg1Of |
proteins,are |
R40112 |
T3174 |
T8430 |
arg1Of |
Env,HIV-1 |
R40128 |
T20023 |
T85837 |
arg2Of |
reservoirs,in |
R40133 |
T66804 |
T71072 |
arg1Of |
surface,"," |
R40189 |
T20594 |
T55010 |
arg1Of |
residues,on |
R402 |
T415 |
T407 |
arg2Of |
known9,are |
R40238 |
T66745 |
T21467 |
arg1Of |
trimer,the |
R40241 |
T58945 |
T28579 |
arg1Of |
number,total |
R40261 |
T26450 |
T82660 |
arg3Of |
),( |
R40287 |
T29223 |
T85418 |
arg1Of |
glycans,( |
R403 |
T415 |
T408 |
arg1Of |
known9,the |
R40328 |
T82693 |
T92120 |
arg2Of |
and,analysed |
R40335 |
T46887 |
T75407 |
arg1Of |
sites,receptor-binding |
R40358 |
T92910 |
T14256 |
arg1Of |
Residues,with |
R40383 |
T17551 |
T64406 |
arg1Of |
shields,the |
R40393 |
T10541 |
T36690 |
arg1Of |
viruses,two |
R404 |
T415 |
T409 |
arg1Of |
known9,largest |
R4041 |
T64807 |
T17288 |
arg1Of |
hemagglutinin,H3N2 |
R40464 |
T30217 |
T58506 |
arg1Of |
modelling,The |
R40472 |
T79677 |
T51290 |
arg1Of |
maps,are |
R40497 |
T63261 |
T55283 |
arg2Of |
leads,showed51 |
R405 |
T415 |
T410 |
arg1Of |
known9,class |
R40578 |
T35349 |
T43036 |
arg1Of |
subunits,The |
R406 |
T415 |
T411 |
arg1Of |
known9,I |
R40679 |
T13068 |
T59646 |
arg1Of |
functionality,the |
R407 |
T415 |
T412 |
arg1Of |
known9,viral |
R40704 |
T89744 |
T23520 |
arg2Of |
antibodies,of |
R40757 |
T57983 |
T18742 |
arg1Of |
"shield54,55",effective |
R40791 |
T37461 |
T30415 |
arg2Of |
it,compare |
R408 |
T415 |
T413 |
arg1Of |
known9,fusion |
R40876 |
T74143 |
T67520 |
arg1Of |
density,overall |
R409 |
T415 |
T414 |
arg1Of |
known9,proteins |
R40920 |
T3180 |
T1782 |
arg1Of |
analysis,HILIC-UPLC |
R40924 |
T55408 |
T2961 |
arg2Of |
ratio,had |
R40953 |
T81925 |
T61603 |
arg1Of |
proteins,SARS |
R40971 |
T28413 |
T30887 |
arg1Of |
targets,are |
R40982 |
T90081 |
T40209 |
arg1Of |
exhibit,not |
R41 |
T44 |
T45 |
arg1Of |
target,of |
R410 |
T417 |
T416 |
arg1Of |
and,"," |
R41063 |
T90139 |
T52708 |
arg1Of |
generated,from |
R411 |
T407 |
T417 |
arg1Of |
are,and |
R41117 |
T59031 |
T90575 |
arg1Of |
glycans,the |
R41132 |
T26477 |
T12300 |
arg1Of |
Left,; |
R41133 |
T61708 |
T19879 |
arg2Of |
5VK2,"," |
R412 |
T420 |
T417 |
arg2Of |
glycosylated,and |
R41263 |
T33037 |
T82290 |
arg1Of |
MERS,and |
R41271 |
T83973 |
T14068 |
arg1Of |
residues,exposed |
R413 |
T406 |
T418 |
arg1Of |
proteins,are |
R41315 |
T30415 |
T70541 |
arg2Of |
compare,and |
R41325 |
T6621 |
T61778 |
arg1Of |
contribute,For |
R41359 |
T26380 |
T35353 |
arg2Of |
value,with |
R41392 |
T56088 |
T12321 |
arg1Of |
Proteins,Spike |
R414 |
T420 |
T418 |
arg2Of |
glycosylated,are |
R41447 |
T55295 |
T82828 |
arg1Of |
proteins,including |
R415 |
T420 |
T419 |
arg1Of |
glycosylated,extensively |
R41505 |
T58945 |
T41351 |
arg2Of |
number,by |
R41577 |
T47272 |
T87179 |
arg1Of |
fusion,receptor-binding |
R41585 |
T76651 |
T24947 |
modOf |
assortment,to |
R416 |
T406 |
T420 |
arg2Of |
proteins,glycosylated |
R41625 |
T31427 |
T20303 |
arg1Of |
proteins,S |
R41690 |
T12133 |
T46991 |
arg1Of |
5X58,ID |
R417 |
T420 |
T421 |
arg1Of |
glycosylated,"," |
R41744 |
T45067 |
T82041 |
arg1Of |
glycans,would |
R418 |
T420 |
T422 |
arg1Of |
glycosylated,with |
R41802 |
T9118 |
T91856 |
arg1Of |
oligomannose-type,fully |
R4181 |
T58744 |
T47642 |
arg1Of |
quality,( |
R41821 |
T35349 |
T63087 |
arg1Of |
subunits,S2 |
R41822 |
T25121 |
T91373 |
arg2Of |
deletions,and |
R41837 |
T87267 |
T68020 |
arg1Of |
glycans,the |
R41847 |
T75223 |
T69929 |
arg1Of |
observe,whereas |
R419 |
T427 |
T422 |
arg2Of |
glycoproteins,with |
R4190 |
T58510 |
T60171 |
arg1Of |
level,a |
R41908 |
T93138 |
T45227 |
arg2Of |
digested,were |
R41935 |
T30499 |
T56293 |
arg1Of |
accessibility,of |
R42 |
T50 |
T45 |
arg2Of |
response,of |
R420 |
T427 |
T423 |
arg1Of |
glycoproteins,SARS |
R42008 |
T73464 |
T91677 |
arg1Of |
library,glycan |
R42024 |
T5164 |
T85081 |
arg1Of |
modelling,of |
R421 |
T423 |
T424 |
arg1Of |
SARS,and |
R42106 |
T61083 |
T70472 |
arg1Of |
and,which |
R42132 |
T61777 |
T53697 |
arg2Of |
maps,in |
R422 |
T425 |
T424 |
arg2Of |
MERS,and |
R42213 |
T81627 |
T18761 |
arg2Of |
grouped,and |
R42276 |
T45843 |
T96415 |
arg2Of |
complex,in |
R423 |
T427 |
T425 |
arg1Of |
glycoproteins,MERS |
R4234 |
T17645 |
T91429 |
arg1Of |
sites,that |
R42340 |
T45067 |
T32694 |
arg1Of |
glycans,these |
R424 |
T427 |
T426 |
arg1Of |
glycoproteins,S |
R42415 |
T24662 |
T41800 |
arg1Of |
GPC,which |
R42488 |
T7370 |
T27090 |
arg1Of |
isolated,more |
R425 |
T429 |
T428 |
arg1Of |
encoding,both |
R42509 |
T84080 |
T27673 |
arg1Of |
changes,no |
R42599 |
T68442 |
T5395 |
arg1Of |
domains,S1 |
R426 |
T427 |
T429 |
arg1Of |
glycoproteins,encoding |
R42646 |
T1963 |
T22023 |
arg2Of |
implicated,been |
R42650 |
T89591 |
T85913 |
arg2Of |
shown,are |
R427 |
T433 |
T429 |
arg2Of |
sequons,encoding |
R42703 |
T25304 |
T27779 |
arg1Of |
sequences,available |
R42722 |
T68543 |
T48920 |
arg1Of |
glycoproteins,viral |
R42761 |
T30887 |
T56103 |
arg1Of |
are,"," |
R428 |
T433 |
T430 |
arg1Of |
sequons,69 |
R42808 |
T74594 |
T33006 |
arg1Of |
structure,the |
R42830 |
T96477 |
T31963 |
arg1Of |
amino-acids,interact |
R42837 |
T66804 |
T23712 |
arg1Of |
surface,surface |
R429 |
T433 |
T431 |
arg1Of |
sequons,N-linked |
R42900 |
T11057 |
T72208 |
arg1Of |
analysis,of |
R42903 |
T33263 |
T91161 |
arg1Of |
and,for |
R42911 |
T27706 |
T3633 |
arg1Of |
and,( |
R42935 |
T49864 |
T33083 |
arg1Of |
glycans,( |
R42948 |
T37933 |
T95071 |
arg3Of |
and,observed |
R43 |
T50 |
T46 |
arg1Of |
response,the |
R430 |
T433 |
T432 |
arg1Of |
sequons,glycan |
R43019 |
T13068 |
T56626 |
arg1Of |
functionality,intrinsic |
R431 |
T433 |
T434 |
arg1Of |
sequons,per |
R43123 |
T13983 |
T15475 |
arg1Of |
arise,"," |
R43138 |
T2686 |
T61552 |
arg1Of |
shield,the |
R432 |
T436 |
T434 |
arg2Of |
spike,per |
R43217 |
T19161 |
T96776 |
arg1Of |
reminiscent,of |
R43254 |
T21412 |
T34895 |
arg2Of |
plotted,and |
R43272 |
T25862 |
T59533 |
arg1Of |
glycosylated,fully |
R433 |
T436 |
T435 |
arg1Of |
spike,trimeric |
R43325 |
T23904 |
T45261 |
arg1Of |
PNGs,rather |
R43360 |
T43250 |
T52169 |
arg1Of |
results,in |
R434 |
T436 |
T437 |
arg1Of |
spike,with |
R43446 |
T72666 |
T29830 |
arg1Of |
approach,which |
R43475 |
T44348 |
T26533 |
arg1Of |
MERS,a |
R435 |
T438 |
T437 |
arg2Of |
SARS-CoV-2,with |
R43507 |
T65533 |
T63649 |
arg2Of |
coronavirus,of |
R43509 |
T30217 |
T75169 |
arg1Of |
modelling,is |
R43519 |
T79396 |
T13436 |
arg2Of |
fail,but |
R43549 |
T71311 |
T55810 |
arg1Of |
number,the |
R43590 |
T83020 |
T39523 |
arg1Of |
presence,of |
R43596 |
T47078 |
T70372 |
arg1Of |
possesses,"," |
R436 |
T438 |
T439 |
arg1Of |
SARS-CoV-2,containing |
R43624 |
T69399 |
T37758 |
arg2Of |
glycans,from |
R43629 |
T32530 |
T12832 |
arg2Of |
are,Although |
R43660 |
T90304 |
T48372 |
arg1Of |
Fig. 8,SI |
R437 |
T441 |
T439 |
arg2Of |
sites,containing |
R43706 |
T86749 |
T48770 |
arg1Of |
to,due |
R43741 |
T11314 |
T81842 |
arg1Of |
Env,surface |
R43772 |
T12246 |
T83739 |
arg2Of |
sites,in |
R43779 |
T83984 |
T27307 |
arg1Of |
it,may |
R438 |
T441 |
T440 |
arg1Of |
sites,66 |
R43806 |
T78856 |
T43948 |
arg1Of |
research,coronavirus |
R43856 |
T28413 |
T16688 |
arg1Of |
targets,for |
R439 |
T443 |
T442 |
arg1Of |
modifications,These |
R43979 |
T2696 |
T40337 |
arg2Of |
occluded,surprising |
R43983 |
T82375 |
T45711 |
arg3Of |
),( |
R44 |
T50 |
T47 |
arg1Of |
response,neutralizing |
R440 |
T445 |
T444 |
arg1Of |
mask,often |
R44043 |
T85744 |
T95434 |
arg1Of |
immunity65,mucosal |
R44071 |
T65533 |
T59243 |
arg1Of |
coronavirus,SARS |
R4409 |
T49864 |
T40035 |
arg2Of |
glycans,fucosylated |
R441 |
T443 |
T445 |
arg1Of |
modifications,mask |
R44107 |
T6955 |
T40144 |
arg1Of |
apart,from |
R44135 |
T31301 |
T96403 |
arg1Of |
and,PDB |
R44147 |
T85741 |
T18381 |
arg1Of |
map,the |
R44156 |
T20304 |
T57102 |
arg1Of |
differences,in |
R442 |
T448 |
T445 |
arg2Of |
epitopes,mask |
R44274 |
T58945 |
T84292 |
arg1Of |
number,of |
R44275 |
T40164 |
T82683 |
arg2Of |
materials,deposited |
R44281 |
T10053 |
T45372 |
arg2Of |
speculate,tempting |
R4429 |
T71311 |
T36859 |
arg1Of |
number,of |
R443 |
T448 |
T446 |
arg1Of |
epitopes,immunogenic |
R44314 |
T38232 |
T35432 |
arg1Of |
traces,with |
R44339 |
T94857 |
T50642 |
arg1Of |
Mapping,dN/dS |
R44359 |
T68640 |
T12304 |
arg2Of |
proteins,and |
R44377 |
T86129 |
T85948 |
arg1Of |
viruses,perturbing |
R44378 |
T3262 |
T46103 |
arg1Of |
glycoproteins,MERS |
R444 |
T448 |
T447 |
arg1Of |
epitopes,protein |
R44430 |
T33229 |
T36523 |
arg3Of |
being,with |
R44451 |
T46741 |
T29063 |
arg3Of |
),( |
R44466 |
T74546 |
T66965 |
arg1Of |
investigated,during |
R44474 |
T31010 |
T21278 |
arg1Of |
correlation,was |
R44490 |
T94035 |
T84875 |
arg2Of |
and,generated |
R445 |
T448 |
T449 |
arg1Of |
epitopes,from |
R44507 |
T10541 |
T54679 |
arg1Of |
viruses,the |
R44564 |
T23338 |
T81584 |
arg1Of |
HA50,influenza |
R44596 |
T61083 |
T83245 |
arg2Of |
and,of |
R446 |
T454 |
T449 |
arg2Of |
system,from |
R44667 |
T68543 |
T26853 |
arg1Of |
glycoproteins,were |
R447 |
T454 |
T450 |
arg1Of |
system,the |
R44708 |
T61369 |
T23395 |
arg1Of |
ratio,the |
R44731 |
T66273 |
T73691 |
arg1Of |
biomolecules,and |
R44751 |
T90188 |
T5712 |
arg1Of |
map,( |
R4478 |
T44180 |
T85300 |
arg3Of |
),( |
R448 |
T454 |
T451 |
arg1Of |
system,host |
R44817 |
T20048 |
T5602 |
arg1Of |
response,immune |
R4483 |
T33538 |
T88529 |
arg1Of |
glycosylation,does |
R44853 |
T90485 |
T16896 |
arg1Of |
exemplifies,as |
R44856 |
T95927 |
T12646 |
arg2Of |
fucosylation,of |
R44894 |
T21025 |
T57630 |
arg1Of |
abundances,Oligomannose |
R449 |
T454 |
T452 |
arg1Of |
system,humoral |
R44924 |
T55408 |
T37460 |
arg1Of |
ratio,dN/dS |
R44930 |
T85744 |
T40686 |
arg2Of |
immunity65,produce |
R4494 |
T97014 |
T84588 |
arg1Of |
response,to |
R44950 |
T8574 |
T84302 |
arg1Of |
highlighted,when |
R44953 |
T58389 |
T28787 |
arg1Of |
Investigation,of |
R45 |
T50 |
T48 |
arg1Of |
response,humoral |
R450 |
T454 |
T453 |
arg1Of |
system,immune |
R45016 |
T82084 |
T6952 |
arg1Of |
S,MERS |
R451 |
T445 |
T455 |
arg1Of |
mask,by |
R45114 |
T6523 |
T15902 |
arg2Of |
interesting,is |
R45134 |
T86925 |
T92642 |
arg1Of |
series,( |
R45175 |
T24662 |
T50837 |
arg1Of |
GPC,smaller |
R4519 |
T38232 |
T94309 |
arg1Of |
traces,backbone |
R452 |
T456 |
T455 |
arg2Of |
occluding,by |
R45240 |
T99824 |
T42535 |
arg1Of |
density,"," |
R45247 |
T46678 |
T91843 |
arg1Of |
we,performed |
R45262 |
T68442 |
T9018 |
arg1Of |
domains,N-terminal |
R45273 |
T1670 |
T25939 |
arg2Of |
trimming,revealed |
R45278 |
T83381 |
T40184 |
arg1Of |
glycosylation,surface |
R453 |
T443 |
T456 |
arg1Of |
modifications,occluding |
R45316 |
T93322 |
T15821 |
arg2Of |
context,in |
R45373 |
T55295 |
T57622 |
arg2Of |
proteins,of |
R45386 |
T79677 |
T28675 |
arg1Of |
maps,sensitive |
R454 |
T457 |
T456 |
arg2Of |
them,occluding |
R45480 |
T28935 |
T30994 |
arg1Of |
behaviour,epidemic |
R45481 |
T1963 |
T69555 |
arg1Of |
implicated,"," |
R45489 |
T80173 |
T31925 |
arg1Of |
",","," |
R455 |
T456 |
T458 |
arg1Of |
occluding,with |
R45510 |
T56273 |
T63629 |
arg2Of |
map,Sharpened |
R45513 |
T70541 |
T81037 |
arg1Of |
and,"," |
R4552 |
T34506 |
T30497 |
arg1Of |
with,in |
R45550 |
T54331 |
T78244 |
arg2Of |
SARS,on |
R45557 |
T43194 |
T27706 |
arg1Of |
antennae,and |
R45570 |
T74010 |
T62658 |
arg1Of |
easily,more |
R456 |
T460 |
T458 |
arg2Of |
glycans16–18,with |
R4568 |
T99830 |
T19398 |
arg2Of |
hindered,would |
R45689 |
T47239 |
T7211 |
arg3Of |
),( |
R45699 |
T23058 |
T71875 |
arg1Of |
Fig. 7,SI |
R457 |
T460 |
T459 |
arg1Of |
glycans16–18,host-derived |
R45720 |
T19203 |
T98351 |
arg2Of |
dataset,in |
R45768 |
T67481 |
T99058 |
arg2Of |
such,As |
R45792 |
T15804 |
T53332 |
arg2Of |
elicit,able |
R45798 |
T64807 |
T69427 |
arg1Of |
hemagglutinin,( |
R458 |
T462 |
T461 |
arg1Of |
phenomenon,This |
R45822 |
T24662 |
T66930 |
arg1Of |
GPC,"," |
R45835 |
T59734 |
T62851 |
arg1Of |
constraints,functional |
R45850 |
T72037 |
T23602 |
arg1Of |
most,of |
R45865 |
T40726 |
T54827 |
arg1Of |
spikes,MERS |
R459 |
T462 |
T463 |
arg1Of |
phenomenon,of |
R45968 |
T72299 |
T18939 |
arg2Of |
and,between |
R45989 |
T49217 |
T66723 |
arg1Of |
3,Fig. |
R46 |
T50 |
T49 |
arg1Of |
response,immune |
R460 |
T465 |
T463 |
arg2Of |
evasion,of |
R46003 |
T53332 |
T49759 |
arg2Of |
able,are |
R46016 |
T57528 |
T46492 |
arg2Of |
regions,and |
R46093 |
T78881 |
T31925 |
arg2Of |
4O5N,"," |
R461 |
T465 |
T464 |
arg1Of |
evasion,immune |
R46106 |
T84163 |
T11703 |
arg2Of |
FA4,to |
R46136 |
T68442 |
T72184 |
arg1Of |
domains,extending |
R462 |
T462 |
T466 |
arg1Of |
phenomenon,by |
R46219 |
T76130 |
T75367 |
arg1Of |
site,receptor-binding |
R46249 |
T27706 |
T75194 |
arg1Of |
and,( |
R46291 |
T49179 |
T34506 |
arg2Of |
vitro59,with |
R463 |
T469 |
T466 |
arg2Of |
and,by |
R46306 |
T11621 |
T84900 |
arg1Of |
offer,not |
R4632 |
T2559 |
T24147 |
arg1Of |
grey,and |
R46333 |
T85744 |
T65430 |
arg1Of |
immunity65,sufficient |
R464 |
T468 |
T467 |
arg1Of |
mimicry,molecular |
R46405 |
T10989 |
T31245 |
arg2Of |
"response21,31",from |
R46471 |
T85689 |
T43310 |
arg2Of |
proportion,occludes |
R46477 |
T55295 |
T77114 |
arg1Of |
proteins,viral |
R465 |
T468 |
T469 |
arg1Of |
mimicry,and |
R46535 |
T28413 |
T23034 |
arg1Of |
targets,likely |
R46556 |
T21879 |
T97449 |
arg1Of |
S,( |
R46559 |
T18714 |
T16269 |
arg1Of |
shield,which |
R4656 |
T51052 |
T89745 |
arg1Of |
observed,on |
R46593 |
T30265 |
T8292 |
arg1Of |
reproduced,from |
R466 |
T471 |
T469 |
arg2Of |
shielding,and |
R46603 |
T26533 |
T48343 |
arg1Of |
a,( |
R46655 |
T49864 |
T85300 |
arg1Of |
glycans,( |
R46661 |
T63465 |
T16896 |
arg2Of |
virus,as |
R46674 |
T7550 |
T2009 |
arg2Of |
accumulation,to |
R46682 |
T62928 |
T41459 |
arg1Of |
glycans,here |
R467 |
T471 |
T470 |
arg1Of |
shielding,glycan |
R4670 |
T67337 |
T2332 |
arg1Of |
cluster,this |
R46738 |
T28555 |
T69590 |
arg2Of |
such,As |
R46751 |
T4558 |
T25400 |
arg2Of |
domains,of |
R46764 |
T88367 |
T70083 |
arg1Of |
levels,of |
R46771 |
T95274 |
T70578 |
arg2Of |
vulnerability,of |
R46778 |
T9459 |
T3983 |
arg1Of |
application,U.S. |
R468 |
T462 |
T472 |
arg1Of |
phenomenon,has |
R46838 |
T90138 |
T82634 |
arg2Of |
SARS,and |
R469 |
T475 |
T472 |
arg2Of |
characterised,has |
R47 |
T50 |
T51 |
arg1Of |
response,"," |
R470 |
T462 |
T473 |
arg1Of |
phenomenon,been |
R47042 |
T53941 |
T90782 |
arg1Of |
SOSIP.664,HIV-1 |
R47087 |
T89747 |
T50969 |
arg2Of |
accretion,limit |
R471 |
T475 |
T473 |
arg2Of |
characterised,been |
R4710 |
T49949 |
T66016 |
arg1Of |
findings,of |
R47110 |
T8069 |
T79028 |
arg2Of |
glycan28,access |
R47138 |
T64538 |
T97000 |
arg1Of |
notion,This |
R47143 |
T12192 |
T69312 |
arg2Of |
presented,and |
R47162 |
T86129 |
T8489 |
arg1Of |
viruses,other |
R47190 |
T42487 |
T44308 |
arg1Of |
evaluation,an |
R472 |
T475 |
T474 |
arg1Of |
characterised,well |
R47204 |
T53169 |
T28124 |
arg2Of |
GPC,"," |
R47214 |
T97427 |
T80942 |
arg1Of |
and,both |
R47263 |
T40726 |
T64040 |
arg2Of |
spikes,and |
R473 |
T462 |
T475 |
arg2Of |
phenomenon,characterised |
R47307 |
T91973 |
T67415 |
arg1Of |
but,"," |
R47308 |
T92070 |
T38048 |
arg2Of |
proteins,of |
R47345 |
T96851 |
T93743 |
arg2Of |
substitutions,to |
R474 |
T475 |
T476 |
arg1Of |
characterised,across |
R47461 |
T2132 |
T30799 |
arg1Of |
fucosylation,and |
R47479 |
T16970 |
T13320 |
arg3Of |
),( |
R47491 |
T22031 |
T76564 |
arg2Of |
analysis,performed |
R475 |
T479 |
T476 |
arg2Of |
glycoproteins,across |
R47551 |
T52910 |
T73267 |
arg1Of |
and,for |
R47563 |
T7777 |
T27277 |
arg2Of |
regions,in |
R47592 |
T52475 |
T58850 |
arg1Of |
conservation,of |
R476 |
T479 |
T477 |
arg1Of |
glycoproteins,other |
R47619 |
T18965 |
T72137 |
arg1Of |
proteins,from |
R47642 |
T71776 |
T35226 |
arg1Of |
interactions,drive |
R4765 |
T6629 |
T64812 |
arg1Of |
compositions,their |
R47678 |
T72393 |
T19972 |
arg2Of |
reprocessed,was |
R47689 |
T13068 |
T18164 |
arg2Of |
functionality,from |
R47693 |
T67976 |
T10009 |
arg2Of |
glycome,studied |
R477 |
T479 |
T478 |
arg1Of |
glycoproteins,viral |
R47712 |
T19500 |
T8001 |
arg2Of |
with,"," |
R478 |
T479 |
T480 |
arg1Of |
glycoproteins,"," |
R47828 |
T79246 |
T85438 |
arg1Of |
oligomannose,"," |
R47832 |
T61005 |
T36851 |
arg1Of |
Env,HIV-1 |
R47847 |
T72195 |
T32938 |
arg1Of |
recognition,innate |
R47875 |
T46654 |
T89915 |
arg1Of |
data,the |
R479 |
T482 |
T481 |
arg1Of |
as,such |
R4790 |
T59734 |
T18450 |
arg1Of |
constraints,"," |
R47903 |
T19690 |
T64282 |
arg1Of |
weight,molecular |
R47914 |
T25884 |
T91293 |
arg1Of |
values,Averaged |
R47946 |
T71298 |
T42034 |
arg1Of |
glycoproteins,"," |
R47997 |
T33036 |
T26191 |
arg1Of |
subunit,this |
R48 |
T57 |
T51 |
arg2Of |
glycoprotein,"," |
R480 |
T479 |
T482 |
arg1Of |
glycoproteins,as |
R48001 |
T72197 |
T51090 |
arg2Of |
glycoproteins,to |
R48079 |
T43250 |
T2441 |
arg1Of |
results,at |
R481 |
T497 |
T482 |
arg2Of |
and,as |
R482 |
T485 |
T483 |
arg1Of |
protein,HIV-1 |
R48201 |
T72369 |
T85886 |
arg2Of |
substitutions,of |
R48243 |
T68681 |
T47375 |
arg1Of |
knock,to |
R48247 |
T91715 |
T67031 |
arg1Of |
glycoproteins,"," |
R4827 |
T31427 |
T86504 |
arg2Of |
proteins,alkylated |
R483 |
T485 |
T484 |
arg1Of |
protein,envelope |
R48312 |
T15412 |
T5507 |
arg1Of |
domains,that |
R48342 |
T64331 |
T68155 |
arg1Of |
ratios,compared |
R4839 |
T52754 |
T74888 |
arg1Of |
MERS,the |
R48396 |
T2410 |
T71292 |
arg2Of |
sites,of |
R484 |
T492 |
T485 |
arg1Of |
hemagglutinin,protein |
R485 |
T485 |
T486 |
arg1Of |
protein,( |
R48506 |
T36827 |
T39186 |
arg1Of |
we,found |
R48535 |
T5294 |
T43304 |
arg1Of |
:,Same |
R48587 |
T83973 |
T81366 |
arg1Of |
residues,across |
R486 |
T487 |
T486 |
arg2Of |
Env,( |
R48661 |
T34602 |
T35226 |
arg2Of |
structuring,drive |
R48676 |
T79360 |
T22927 |
arg3Of |
),( |
R48682 |
T31427 |
T8652 |
arg2Of |
proteins,digested |
R487 |
T488 |
T486 |
arg3Of |
),( |
R4871 |
T44348 |
T9629 |
arg1Of |
MERS,and |
R488 |
T485 |
T489 |
arg1Of |
protein,19–21 |
R48801 |
T48779 |
T50978 |
arg1Of |
indicated,in |
R48827 |
T32624 |
T48510 |
arg1Of |
diversity,low |
R4883 |
T15871 |
T73572 |
arg1Of |
March,2020 |
R48890 |
T38716 |
T23248 |
arg1Of |
note,it |
R489 |
T485 |
T490 |
arg1Of |
protein,"," |
R48951 |
T13436 |
T32116 |
arg1Of |
but,"," |
R48982 |
T81512 |
T36523 |
arg2Of |
18,with |
R48987 |
T20023 |
T29947 |
arg1Of |
reservoirs,their |
R49 |
T57 |
T52 |
arg1Of |
glycoprotein,the |
R490 |
T491 |
T490 |
arg2Of |
influenza,"," |
R49041 |
T30887 |
T81494 |
modOf |
are,resulting |
R49061 |
T59632 |
T61432 |
arg2Of |
unable,are |
R49064 |
T28690 |
T40406 |
arg2Of |
disallow,and |
R49097 |
T54724 |
T84302 |
arg2Of |
mapped,when |
R491 |
T492 |
T491 |
arg1Of |
hemagglutinin,influenza |
R49150 |
T29760 |
T53742 |
arg1Of |
repeat,one |
R49164 |
T86129 |
T10448 |
arg1Of |
viruses,are |
R492 |
T492 |
T493 |
arg1Of |
hemagglutinin,( |
R49206 |
T19161 |
T38719 |
arg2Of |
reminiscent,is |
R49214 |
T59031 |
T7370 |
arg1Of |
glycans,isolated |
R49275 |
T82693 |
T86575 |
arg2Of |
and,with |
R4929 |
T73605 |
T82163 |
arg1Of |
flexibility,of |
R493 |
T494 |
T493 |
arg2Of |
HA,( |
R4932 |
T95444 |
T32530 |
arg2Of |
available,are |
R49381 |
T12652 |
T92287 |
arg1Of |
residues,exhibited |
R49383 |
T76860 |
T24256 |
arg1Of |
glycans,are |
R494 |
T495 |
T493 |
arg3Of |
),( |
R49403 |
T68609 |
T79273 |
arg1Of |
structures,the |
R49442 |
T91463 |
T52453 |
arg3Of |
coming,with |
R49465 |
T10989 |
T10149 |
arg1Of |
"response21,31",the |
R49480 |
T74143 |
T65417 |
arg1Of |
density,differ |
R495 |
T492 |
T496 |
arg1Of |
hemagglutinin,"22,23" |
R49514 |
T21366 |
T42060 |
arg1Of |
sites,potential |
R4952 |
T90192 |
T33187 |
arg1Of |
number,the |
R49529 |
T44450 |
T32211 |
arg1Of |
coronaviruses,elicit |
R49539 |
T70602 |
T31999 |
arg2Of |
Assemblies,and |
R496 |
T492 |
T497 |
arg1Of |
hemagglutinin,and |
R49617 |
T16112 |
T11619 |
arg1Of |
diversification,Amino-acid |
R49633 |
T80856 |
T94093 |
arg1Of |
SARS,and |
R49659 |
T83984 |
T34676 |
arg1Of |
it,be |
R49698 |
T24622 |
T82222 |
arg2Of |
codes,with |
R497 |
T501 |
T497 |
arg2Of |
complex,and |
R49729 |
T81137 |
T95497 |
arg2Of |
common,in |
R49756 |
T1963 |
T79414 |
arg2Of |
implicated,has |
R49770 |
T49099 |
T58919 |
arg1Of |
domain,and |
R498 |
T501 |
T498 |
arg1Of |
complex,Lassa |
R49825 |
T72291 |
T42416 |
arg1Of |
colored,respectively |
R4989 |
T67339 |
T83021 |
arg1Of |
classified,historically |
R499 |
T501 |
T499 |
arg1Of |
complex,virus |
R4990 |
T61083 |
T16556 |
arg1Of |
and,was |
R49906 |
T61867 |
T39961 |
arg1Of |
GPC,LASV |
R49912 |
T74594 |
T14723 |
arg2Of |
structure,on |
R49923 |
T16458 |
T19972 |
arg1Of |
dataset52,was |
R4994 |
T94871 |
T29556 |
arg1Of |
shield,glycan |
R49965 |
T7777 |
T89562 |
arg1Of |
regions,the |
R5 |
T7 |
T5 |
arg2Of |
glycosylation,despite |
R50 |
T57 |
T53 |
arg1Of |
glycoprotein,spike |
R500 |
T501 |
T500 |
arg1Of |
complex,glycoprotein |
R50005 |
T42122 |
T96563 |
arg1Of |
signal,low |
R50077 |
T27344 |
T14035 |
arg1Of |
“2019-nCoV,Vaccine” |
R501 |
T501 |
T502 |
arg1Of |
complex,( |
R50107 |
T24662 |
T43310 |
arg1Of |
GPC,occludes |
R50123 |
T68738 |
T17336 |
arg2Of |
comparable,are |
R50127 |
T18666 |
T75900 |
arg1Of |
spectrometry,liquid |
R50130 |
T43310 |
T57424 |
arg1Of |
occludes,with |
R50155 |
T34772 |
T66915 |
arg2Of |
Asn236,and |
R50174 |
T78948 |
T68155 |
arg2Of |
with,compared |
R502 |
T504 |
T502 |
arg2Of |
GPC,( |
R50205 |
T53506 |
T70792 |
arg1Of |
is,"," |
R50247 |
T94405 |
T25862 |
arg1Of |
model,glycosylated |
R50264 |
T68729 |
T34685 |
arg2Of |
volume,and |
R503 |
T505 |
T502 |
arg3Of |
),( |
R50307 |
T90188 |
T98545 |
arg1Of |
map,filtered |
R50333 |
T12304 |
T83177 |
arg2Of |
and,of |
R50360 |
T68396 |
T16273 |
arg1Of |
MS,LC-ESI |
R50373 |
T8574 |
T87038 |
arg1Of |
highlighted,"," |
R50397 |
T15627 |
T43286 |
arg1Of |
nanobodies,penetrate |
R504 |
T504 |
T503 |
arg1Of |
GPC,LASV |
R50403 |
T82683 |
T70752 |
arg1Of |
deposited,In |
R50475 |
T19099 |
T77842 |
arg1Of |
protrude,away |
R505 |
T501 |
T506 |
arg1Of |
complex,24–26 |
R50544 |
T8512 |
T12260 |
arg2Of |
coronaviruses,of |
R50550 |
T86335 |
T63374 |
arg2Of |
glycan,of |
R50563 |
T18965 |
T40757 |
arg1Of |
proteins,S |
R50586 |
T33045 |
T90570 |
arg1Of |
quantification,of |
R506 |
T508 |
T507 |
arg1Of |
analyses,Previous |
R50639 |
T3337 |
T80636 |
arg1Of |
shield51,Env |
R50646 |
T30217 |
T85671 |
arg2Of |
modelling,illustrated |
R50668 |
T99242 |
T28913 |
arg1Of |
head,the |
R50693 |
T36213 |
T36917 |
arg2Of |
10.25345/C58T21,[ |
R507 |
T508 |
T509 |
arg1Of |
analyses,of |
R50718 |
T2410 |
T61275 |
arg1Of |
sites,glycan |
R508 |
T512 |
T509 |
arg2Of |
shields,of |
R50879 |
T96423 |
T51670 |
arg1Of |
spikes,glycosylated |
R509 |
T512 |
T510 |
arg1Of |
shields,viral |
R50925 |
T74519 |
T69698 |
arg2Of |
glycans,clustered |
R51 |
T53 |
T54 |
arg1Of |
spike,( |
R510 |
T512 |
T511 |
arg1Of |
shields,glycan |
R511 |
T508 |
T513 |
arg1Of |
analyses,have |
R51120 |
T50573 |
T29922 |
arg1Of |
and,for |
R51133 |
T55061 |
T81144 |
arg1Of |
cells,canine |
R51134 |
T96477 |
T57287 |
arg1Of |
amino-acids,that |
R51193 |
T46357 |
T17558 |
arg2Of |
differences,divided |
R512 |
T514 |
T513 |
arg2Of |
revealed,have |
R51225 |
T6892 |
T83032 |
arg2Of |
likely,is |
R513 |
T508 |
T514 |
arg1Of |
analyses,revealed |
R51304 |
T4129 |
T94035 |
arg2Of |
5X58,and |
R51307 |
T82481 |
T19623 |
arg1Of |
subunit,to |
R51342 |
T85070 |
T7334 |
arg2Of |
it,"," |
R51375 |
T80657 |
T69498 |
arg1Of |
protein,class |
R514 |
T516 |
T514 |
arg2Of |
presence,revealed |
R5141 |
T83825 |
T42572 |
arg1Of |
indicate,onto |
R51441 |
T11621 |
T46258 |
arg2Of |
offer,would |
R51450 |
T78348 |
T5501 |
arg1Of |
Fig. 5,SI |
R515 |
T516 |
T515 |
arg1Of |
presence,the |
R51542 |
T70323 |
T76643 |
arg2Of |
proteins,of |
R516 |
T516 |
T517 |
arg1Of |
presence,of |
R51633 |
T38606 |
T86025 |
arg1Of |
GPC,LASV |
R517 |
T520 |
T517 |
arg2Of |
glycans,of |
R518 |
T520 |
T518 |
arg1Of |
glycans,underprocessed |
R51829 |
T70752 |
T63370 |
arg1Of |
In,to |
R51850 |
T90646 |
T92949 |
arg2Of |
A.B.W.,and |
R519 |
T520 |
T519 |
arg1Of |
glycans,oligomannose-type |
R51926 |
T50082 |
T32901 |
arg1Of |
S,MERS |
R51930 |
T18761 |
T31666 |
arg1Of |
and,"," |
R51942 |
T70323 |
T65032 |
arg1Of |
proteins,CoV |
R52 |
T55 |
T54 |
arg2Of |
S,( |
R520 |
T520 |
T521 |
arg1Of |
glycans,that |
R52004 |
T90347 |
T30100 |
arg2Of |
proteins,of |
R52010 |
T76573 |
T10460 |
arg1Of |
",",and |
R52020 |
T68543 |
T82274 |
arg2Of |
glycoproteins,analysed |
R52028 |
T76361 |
T97427 |
arg2Of |
proteins,and |
R521 |
T523 |
T522 |
arg1Of |
arise,seemingly |
R52171 |
T54061 |
T95868 |
arg1Of |
proteins,S |
R52176 |
T1949 |
T13865 |
arg2Of |
diversity,of |
R52190 |
T53788 |
T31069 |
arg1Of |
functionality,the |
R522 |
T520 |
T523 |
arg1Of |
glycans,arise |
R52218 |
T17864 |
T39535 |
arg1Of |
processing,glycan |
R52224 |
T8512 |
T89645 |
arg1Of |
coronaviruses,important |
R52288 |
T89162 |
T87732 |
arg1Of |
as,can |
R52293 |
T40498 |
T99309 |
arg1Of |
lack,the |
R52294 |
T86019 |
T3693 |
arg1Of |
Fig.,4 |
R523 |
T525 |
T524 |
arg1Of |
to,due |
R52342 |
T39941 |
T86297 |
arg1Of |
genes,current |
R524 |
T523 |
T525 |
arg1Of |
arise,to |
R52410 |
T7069 |
T41089 |
arg1Of |
correspond,to |
R52418 |
T3483 |
T74853 |
arg1Of |
performed,on |
R52454 |
T65049 |
T82162 |
arg2Of |
maintaining,as |
R525 |
T527 |
T525 |
arg2Of |
constraints,to |
R52503 |
T16458 |
T72393 |
arg2Of |
dataset52,reprocessed |
R52525 |
T65533 |
T97323 |
arg1Of |
coronavirus,HIV-1 |
R52529 |
T27050 |
T97416 |
arg1Of |
microscopy,( |
R52562 |
T65828 |
T35353 |
arg1Of |
residues,with |
R52595 |
T35201 |
T66534 |
arg1Of |
reflected,with |
R526 |
T527 |
T526 |
arg1Of |
constraints,steric |
R52621 |
T25939 |
T78905 |
arg1Of |
revealed,"," |
R52677 |
T3262 |
T75132 |
arg1Of |
glycoproteins,coronavirus |
R527 |
T527 |
T528 |
arg1Of |
constraints,that |
R52700 |
T68027 |
T62278 |
arg2Of |
level,at |
R52712 |
T45843 |
T56194 |
arg1Of |
complex,with |
R52773 |
T76353 |
T21668 |
arg1Of |
evolved,not |
R52778 |
T39117 |
T85438 |
arg2Of |
hybrid,"," |
R528 |
T527 |
T529 |
arg1Of |
constraints,prevent |
R52854 |
T99799 |
T72317 |
arg1Of |
glycoproteins,S |
R52865 |
T73857 |
T80897 |
arg2Of |
convolved,is |
R52881 |
T71298 |
T66756 |
arg1Of |
glycoproteins,other |
R52896 |
T82137 |
T44906 |
arg1Of |
compositions,Glycan |
R529 |
T530 |
T529 |
arg2Of |
access,prevent |
R5294 |
T18648 |
T65761 |
arg1Of |
interactions,additional |
R52971 |
T10175 |
T47018 |
arg1Of |
spectrometry,mass |
R52995 |
T18623 |
T90503 |
arg1Of |
processed,to |
R53 |
T56 |
T54 |
arg3Of |
),( |
R530 |
T530 |
T531 |
arg1Of |
access,of |
R53035 |
T15993 |
T29715 |
arg1Of |
presence,the |
R53073 |
T48265 |
T3818 |
arg1Of |
quantities,the |
R53086 |
T97506 |
T94206 |
arg1Of |
we,showed |
R531 |
T534 |
T531 |
arg2Of |
enzymes,of |
R53186 |
T10045 |
T88998 |
arg1Of |
known,as |
R53198 |
T45911 |
T49036 |
arg1Of |
S,MERS |
R532 |
T534 |
T532 |
arg1Of |
enzymes,glycan |
R53259 |
T76130 |
T21250 |
arg1Of |
site,was |
R53298 |
T94405 |
T98923 |
arg1Of |
model,the |
R533 |
T534 |
T533 |
arg1Of |
enzymes,processing |
R53317 |
T3739 |
T39523 |
arg2Of |
glycosylation,of |
R53320 |
T94093 |
T81366 |
arg2Of |
and,across |
R53389 |
T38716 |
T12601 |
arg1Of |
note,to |
R5339 |
T74721 |
T24667 |
arg1Of |
application,patent |
R534 |
T530 |
T535 |
arg1Of |
access,to |
R5341 |
T70323 |
T12704 |
arg1Of |
proteins,S |
R53447 |
T59672 |
T65945 |
arg2Of |
considered,should |
R53459 |
T55151 |
T19500 |
arg2Of |
H3N2,with |
R53479 |
T19223 |
T56739 |
arg1Of |
comparison,to |
R5348 |
T49936 |
T62735 |
arg1Of |
MERS,and |
R53486 |
T44204 |
T16560 |
arg1Of |
//massive.ucsd.edu,) |
R53490 |
T16685 |
T98764 |
arg1Of |
is,"," |
R535 |
T537 |
T535 |
arg2Of |
"glycans24,27,28",to |
R536 |
T537 |
T536 |
arg1Of |
"glycans24,27,28",substrate |
R53601 |
T69929 |
T55492 |
arg1Of |
whereas,"," |
R537 |
T523 |
T538 |
arg1Of |
arise,"," |
R53776 |
T53051 |
T89368 |
arg1Of |
Env,"9,11,53,84–86" |
R53797 |
T26227 |
T21512 |
arg2Of |
abundance,to |
R538 |
T523 |
T539 |
arg1Of |
arise,especially |
R5382 |
T13983 |
T30720 |
arg1Of |
arise,from |
R53821 |
T32072 |
T34645 |
arg2Of |
5X59,"," |
R539 |
T545 |
T539 |
arg2Of |
evolved,especially |
R53928 |
T31925 |
T95730 |
arg2Of |
",",( |
R53984 |
T75003 |
T15279 |
arg1Of |
data,mass |
R53995 |
T57983 |
T2902 |
arg1Of |
"shield54,55",an |
R54 |
T60 |
T58 |
arg1Of |
proteins,Coronavirus |
R540 |
T539 |
T540 |
arg1Of |
especially,when |
R54019 |
T85969 |
T15501 |
arg1Of |
dynamics,in |
R54077 |
T70221 |
T22664 |
arg1Of |
proteins,S |
R541 |
T543 |
T541 |
arg1Of |
glycoprotein,the |
R54195 |
T90188 |
T66628 |
arg1Of |
map,cryo-EM |
R542 |
T543 |
T542 |
arg1Of |
glycoprotein,viral |
R54218 |
T72184 |
T12801 |
arg1Of |
extending,out |
R54228 |
T96165 |
T8633 |
arg1Of |
residues,amino-acid |
R54237 |
T19623 |
T95917 |
arg1Of |
to,due |
R543 |
T543 |
T544 |
arg1Of |
glycoprotein,has |
R54302 |
T76109 |
T7753 |
arg2Of |
undergoing,would |
R5435 |
T75405 |
T23602 |
arg2Of |
differences,of |
R5439 |
T60225 |
T28690 |
arg1Of |
interactions,disallow |
R54394 |
T39713 |
T83434 |
arg1Of |
they,be |
R54397 |
T4558 |
T95940 |
arg1Of |
domains,these |
R544 |
T545 |
T544 |
arg2Of |
evolved,has |
R5440 |
T75366 |
T27706 |
arg2Of |
presence,and |
R54442 |
T27983 |
T3044 |
arg2Of |
SARS,on |
R54454 |
T1970 |
T44006 |
arg1Of |
in,and |
R54479 |
T68704 |
T3893 |
arg3Of |
exist,shown |
R545 |
T543 |
T545 |
arg1Of |
glycoprotein,evolved |
R54511 |
T3893 |
T80149 |
arg1Of |
shown,"," |
R54519 |
T17113 |
T45227 |
arg1Of |
proteins,were |
R54575 |
T15037 |
T77189 |
arg1Of |
shield,the |
R546 |
T547 |
T545 |
arg2Of |
mask,evolved |
R5462 |
T52475 |
T38716 |
arg2Of |
conservation,note |
R54626 |
T39186 |
T18701 |
arg1Of |
found,Firstly |
R54671 |
T57682 |
T50763 |
arg3Of |
),( |
R54673 |
T38496 |
T6892 |
arg2Of |
shield,likely |
R547 |
T547 |
T546 |
arg1Of |
mask,to |
R5473 |
T3337 |
T64033 |
arg1Of |
shield51,( |
R54761 |
T15412 |
T83531 |
arg2Of |
domains,on |
R548 |
T543 |
T547 |
arg1Of |
glycoprotein,mask |
R54851 |
T18734 |
T34570 |
arg2Of |
glycosylation,of |
R54886 |
T51516 |
T64040 |
arg1Of |
SARS,and |
R54892 |
T44762 |
T96739 |
arg1Of |
labelled,fluorescently |
R549 |
T549 |
T547 |
arg2Of |
epitopes,mask |
R54906 |
T84269 |
T27171 |
arg1Of |
efficacies,Disparate |
R54914 |
T97839 |
T19232 |
arg1Of |
note,to |
R54934 |
T30576 |
T6464 |
arg1Of |
S,"," |
R55 |
T60 |
T59 |
arg1Of |
proteins,S |
R550 |
T549 |
T548 |
arg1Of |
epitopes,immunogenic |
R55098 |
T10070 |
T81627 |
arg1Of |
glycans,grouped |
R551 |
T547 |
T550 |
arg1Of |
mask,with |
R55106 |
T41472 |
T87865 |
arg1Of |
glycosylation,observed |
R55130 |
T33036 |
T59397 |
arg2Of |
subunit,upon |
R55146 |
T86793 |
T90961 |
arg2Of |
epitopes,at |
R55180 |
T97319 |
T36916 |
arg1Of |
role,a |
R552 |
T554 |
T550 |
arg2Of |
array,with |
R5522 |
T46492 |
T30950 |
arg1Of |
and,buried |
R5523 |
T17645 |
T69288 |
arg1Of |
sites,can |
R55233 |
T46654 |
T70752 |
arg3Of |
data,In |
R5524 |
T5302 |
T47005 |
arg1Of |
clusters,specific |
R55289 |
T72680 |
T22467 |
arg1Of |
linked,is |
R55292 |
T80263 |
T21297 |
arg1Of |
development,of |
R553 |
T554 |
T551 |
arg1Of |
array,a |
R5536 |
T1508 |
T80667 |
arg2Of |
boundaries,defines |
R55385 |
T91715 |
T77670 |
arg1Of |
glycoproteins,viral |
R55397 |
T51881 |
T7681 |
arg2Of |
least,processed |
R554 |
T553 |
T552 |
arg1Of |
dense,particularly |
R55446 |
T40686 |
T3099 |
arg1Of |
produce,to |
R555 |
T554 |
T553 |
arg1Of |
array,dense |
R55529 |
T2508 |
T73339 |
arg1Of |
reported,and |
R55540 |
T40134 |
T78070 |
arg2Of |
degrees,to |
R55541 |
T14676 |
T35287 |
arg1Of |
53,virus |
R55552 |
T39186 |
T74266 |
arg1Of |
found,"," |
R55556 |
T58389 |
T98213 |
arg1Of |
Investigation,may |
R55557 |
T82430 |
T2527 |
arg1Of |
combination,simple |
R556 |
T554 |
T555 |
arg1Of |
array,of |
R55649 |
T71298 |
T37978 |
arg2Of |
glycoproteins,on |
R55671 |
T49302 |
T76351 |
arg1Of |
server,the |
R557 |
T557 |
T555 |
arg2Of |
"glycans26,29–34",of |
R558 |
T557 |
T556 |
arg1Of |
"glycans26,29–34",host-derived |
R55817 |
T58510 |
T27128 |
arg1Of |
level,high |
R55821 |
T93961 |
T9745 |
arg1Of |
colored,as |
R55884 |
T12192 |
T24256 |
arg2Of |
presented,are |
R559 |
T559 |
T558 |
arg1Of |
access,Restricted |
R55901 |
T68704 |
T1970 |
arg1Of |
exist,in |
R55902 |
T46831 |
T85214 |
arg1Of |
SARS,and |
R55924 |
T19555 |
T55217 |
arg1Of |
importance,The |
R55949 |
T77922 |
T26521 |
arg1Of |
glycans,on |
R55953 |
T12192 |
T65467 |
arg1Of |
presented,as |
R55954 |
T38716 |
T53506 |
arg1Of |
note,is |
R55957 |
T59935 |
T35748 |
arg2Of |
MERS,on |
R55972 |
T16685 |
T19500 |
arg1Of |
is,with |
R55974 |
T69625 |
T49131 |
arg2Of |
study,for |
R55987 |
T53788 |
T34848 |
arg2Of |
functionality,to |
R55994 |
T83312 |
T96415 |
arg1Of |
construct,in |
R56 |
T60 |
T61 |
arg1Of |
proteins,are |
R560 |
T559 |
T560 |
arg1Of |
access,to |
R56025 |
T92949 |
T44407 |
arg1Of |
and,are |
R561 |
T563 |
T560 |
arg2Of |
sites,to |
R5614 |
T28812 |
T79957 |
arg1Of |
phenomenon,been |
R5616 |
T46694 |
T51798 |
arg3Of |
),( |
R562 |
T563 |
T561 |
arg1Of |
sites,these |
R56245 |
T47125 |
T32555 |
arg1Of |
results,The |
R56289 |
T83020 |
T13036 |
arg1Of |
presence,the |
R56292 |
T23766 |
T72412 |
arg1Of |
reach,why |
R56293 |
T20998 |
T44869 |
arg2Of |
regions,in |
R563 |
T563 |
T562 |
arg1Of |
sites,glycan |
R56320 |
T59603 |
T11718 |
arg1Of |
values,higher |
R56386 |
T67026 |
T3893 |
arg2Of |
domains,shown |
R564 |
T559 |
T564 |
arg1Of |
access,or |
R56401 |
T69246 |
T23472 |
arg2Of |
domain,in |
R5643 |
T90997 |
T80023 |
arg1Of |
mass,"," |
R56486 |
T75405 |
T7434 |
arg1Of |
differences,between |
R565 |
T565 |
T564 |
arg2Of |
interference,or |
R56530 |
T56514 |
T9345 |
arg1Of |
population,glycan |
R56534 |
T30799 |
T43754 |
arg2Of |
and,of |
R56572 |
T82951 |
T68036 |
arg1Of |
hallmark,the |
R56590 |
T54715 |
T81576 |
arg2Of |
glycans,underprocessed |
R566 |
T565 |
T566 |
arg1Of |
interference,with |
R56658 |
T91843 |
T51816 |
arg1Of |
performed,"," |
R56677 |
T89162 |
T32044 |
arg1Of |
as,well |
R567 |
T570 |
T566 |
arg2Of |
or,with |
R56795 |
T64712 |
T17721 |
arg1Of |
bars,error |
R568 |
T569 |
T567 |
arg1Of |
surface,surrounding |
R5680 |
T41193 |
T79801 |
arg2Of |
compositions,ascertain |
R56810 |
T28395 |
T8259 |
arg1Of |
observed,on |
R56816 |
T63979 |
T74853 |
arg2Of |
level,on |
R56819 |
T54008 |
T13224 |
arg1Of |
diversity,amino-acid |
R56835 |
T11869 |
T28667 |
arg2Of |
sites,of |
R569 |
T569 |
T568 |
arg1Of |
surface,protein |
R56933 |
T46492 |
T50177 |
arg1Of |
and,that |
R56965 |
T28675 |
T66740 |
arg1Of |
sensitive,more |
R56973 |
T25052 |
T46492 |
arg1Of |
residues,and |
R57 |
T63 |
T61 |
arg2Of |
glycosylated,are |
R570 |
T569 |
T570 |
arg1Of |
surface,or |
R5701 |
T35106 |
T58672 |
arg1Of |
conserved,on |
R57022 |
T77506 |
T31301 |
arg2Of |
5X59,and |
R57066 |
T64807 |
T16967 |
arg1Of |
hemagglutinin,Influenza |
R57067 |
T73688 |
T54909 |
arg2Of |
effects,of |
R57079 |
T90997 |
T41537 |
arg1Of |
mass,overall |
R5709 |
T70745 |
T5519 |
arg1Of |
families,as |
R571 |
T573 |
T570 |
arg2Of |
residues,or |
R57152 |
T2696 |
T90378 |
arg1Of |
occluded,that |
R57155 |
T11314 |
T58293 |
arg1Of |
Env,glycans |
R572 |
T573 |
T571 |
arg1Of |
residues,neighbouring |
R57227 |
T79756 |
T40313 |
arg1Of |
diversification,amino-acid |
R57229 |
T80082 |
T35120 |
arg2Of |
glycopeptides,subjected |
R57246 |
T58053 |
T9637 |
arg2Of |
MSV000085152,and |
R57265 |
T22009 |
T47879 |
arg2Of |
conformations52,down |
R57290 |
T48593 |
T91161 |
arg2Of |
interactions,for |
R573 |
T573 |
T572 |
arg1Of |
residues,glycan |
R57330 |
T18666 |
T31589 |
arg1Of |
spectrometry,chromatography-mass |
R57363 |
T60289 |
T75223 |
arg1Of |
We,observe |
R574 |
T564 |
T574 |
arg1Of |
or,can |
R57447 |
T15145 |
T60855 |
arg2Of |
contrast,In |
R57469 |
T40337 |
T1822 |
arg2Of |
surprising,is |
R575 |
T575 |
T574 |
arg2Of |
render,can |
R57536 |
T33045 |
T57945 |
arg2Of |
quantification,summarise |
R57557 |
T52754 |
T33039 |
arg2Of |
MERS,of |
R57572 |
T28685 |
T14464 |
arg1Of |
proteins,I |
R57589 |
T72173 |
T72299 |
arg1Of |
SARS,and |
R57595 |
T40473 |
T81627 |
arg2Of |
according,grouped |
R576 |
T564 |
T575 |
arg1Of |
or,render |
R57657 |
T60933 |
T67945 |
arg2Of |
illustrated,is |
R57681 |
T8708 |
T8441 |
arg1Of |
importance,in |
R577 |
T578 |
T575 |
arg2Of |
enzymes,render |
R57707 |
T2410 |
T35106 |
arg2Of |
sites,conserved |
R57723 |
T76564 |
T45093 |
modOf |
performed,to |
R57764 |
T6621 |
T32139 |
arg1Of |
contribute,likely |
R57790 |
T61369 |
T65163 |
arg2Of |
ratio,of |
R578 |
T578 |
T576 |
arg1Of |
enzymes,glycan |
R57807 |
T29035 |
T64910 |
arg2Of |
Comparison,below. |
R57832 |
T10006 |
T72299 |
arg2Of |
SARS-CoV-2,and |
R579 |
T578 |
T577 |
arg1Of |
enzymes,processing |
R57902 |
T37933 |
T36713 |
arg1Of |
and,"," |
R57960 |
T86335 |
T22368 |
arg1Of |
glycan,25 |
R57966 |
T3442 |
T14224 |
arg3Of |
),( |
R57987 |
T46529 |
T15001 |
arg2Of |
S1,on |
R58 |
T63 |
T62 |
arg1Of |
glycosylated,extensively |
R580 |
T578 |
T579 |
arg1Of |
enzymes,ineffective |
R58022 |
T26975 |
T50401 |
arg2Of |
network,to |
R58028 |
T29672 |
T32530 |
arg1Of |
datasets,are |
R58051 |
T52131 |
T31210 |
arg2Of |
N-glycans,of |
R58091 |
T42803 |
T98608 |
arg1Of |
Fig. 3,SI |
R581 |
T579 |
T580 |
arg1Of |
ineffective,in |
R58120 |
T7879 |
T43250 |
arg1Of |
structure,results |
R58191 |
T53941 |
T13950 |
arg1Of |
SOSIP.664,Env |
R58193 |
T11359 |
T63374 |
arg1Of |
consist,of |
R582 |
T582 |
T580 |
arg2Of |
"regions27,28,35",in |
R58201 |
T26975 |
T69150 |
arg1Of |
network,extensive |
R58211 |
T84168 |
T41531 |
arg1Of |
glycans,N-linked |
R58230 |
T1909 |
T61501 |
arg1Of |
",","," |
R58232 |
T17681 |
T49759 |
arg1Of |
candidates,are |
R58277 |
T82870 |
T51016 |
arg1Of |
protein,the |
R583 |
T582 |
T581 |
arg1Of |
"regions27,28,35",specific |
R58315 |
T94581 |
T64033 |
arg3Of |
),( |
R58316 |
T36644 |
T11498 |
arg2Of |
ascertained,were |
R58325 |
T53169 |
T48490 |
arg1Of |
GPC,LASV |
R58336 |
T58389 |
T89551 |
arg1Of |
Investigation,offer |
R58371 |
T38496 |
T46550 |
arg1Of |
shield,that |
R58398 |
T1949 |
T59041 |
arg1Of |
diversity,per |
R584 |
T584 |
T583 |
arg1Of |
processing,Glycan |
R58404 |
T64497 |
T27441 |
arg2Of |
inventor,is |
R58419 |
T79406 |
T92544 |
arg2Of |
0.45,of |
R58427 |
T40801 |
T27804 |
arg1Of |
are,"," |
R58435 |
T58945 |
T50799 |
arg1Of |
number,the |
R5844 |
T12473 |
T30751 |
arg2Of |
reduced,was |
R58449 |
T80844 |
T50530 |
arg2Of |
networks,lack |
R5847 |
T17336 |
T85225 |
arg2Of |
are,Although |
R585 |
T584 |
T585 |
arg1Of |
processing,on |
R58533 |
T51449 |
T66872 |
arg1Of |
proteins,seven |
R58586 |
T12652 |
T4328 |
arg2Of |
residues,exposed |
R586 |
T587 |
T585 |
arg2Of |
glycoproteins,on |
R58609 |
T70460 |
T83202 |
arg1Of |
clustering,glycan |
R58623 |
T95555 |
T21512 |
arg1Of |
contribute,to |
R58633 |
T49812 |
T54764 |
arg2Of |
particles,from |
R58664 |
T53545 |
T22648 |
arg1Of |
enzymes,glycan |
R58669 |
T18888 |
T53506 |
arg2Of |
interesting,is |
R587 |
T587 |
T586 |
arg1Of |
glycoproteins,soluble |
R58702 |
T47078 |
T81728 |
arg1Of |
possesses,compared |
R58705 |
T19314 |
T8259 |
arg2Of |
MERS,on |
R58717 |
T89591 |
T64910 |
arg1Of |
shown,below. |
R58754 |
T79677 |
T52275 |
arg1Of |
maps,reveal |
R58770 |
T53788 |
T35971 |
arg1Of |
functionality,"," |
R58772 |
T15651 |
T48291 |
arg1Of |
resolution,poor |
R58777 |
T30576 |
T72214 |
arg1Of |
S,( |
R5878 |
T50969 |
T51721 |
arg1Of |
limit,"," |
R58787 |
T72037 |
T58264 |
arg1Of |
most,competent |
R588 |
T584 |
T588 |
arg1Of |
processing,has |
R5883 |
T86793 |
T69090 |
arg2Of |
epitopes,known |
R58840 |
T26380 |
T91154 |
arg1Of |
value,a |
R58873 |
T48265 |
T64768 |
arg2Of |
quantities,represent |
R58879 |
T68204 |
T48812 |
arg2Of |
measured,are |
R589 |
T591 |
T588 |
arg2Of |
shown,has |
R58922 |
T81038 |
T50998 |
arg2Of |
Man5GlcNAc2,to |
R5899 |
T46270 |
T13544 |
arg2Of |
models,of |
R58997 |
T66915 |
T49578 |
arg1Of |
and,"," |
R58999 |
T39891 |
T35333 |
arg1Of |
core,central |
R59 |
T60 |
T63 |
arg2Of |
proteins,glycosylated |
R590 |
T591 |
T589 |
arg1Of |
shown,also |
R59003 |
T16685 |
T66750 |
arg1Of |
is,compared |
R59010 |
T48849 |
T57102 |
arg2Of |
ecology,in |
R59063 |
T59935 |
T9158 |
arg1Of |
MERS,a |
R59081 |
T17681 |
T79396 |
arg1Of |
candidates,fail |
R59094 |
T12587 |
T26996 |
arg1Of |
environment,the |
R591 |
T584 |
T590 |
arg1Of |
processing,been |
R59119 |
T35287 |
T87593 |
arg1Of |
virus,S41 |
R59125 |
T49977 |
T70719 |
arg1Of |
responses,immune |
R59136 |
T82430 |
T32469 |
arg1Of |
combination,of |
R5916 |
T24392 |
T77635 |
arg2Of |
MERS,on |
R592 |
T591 |
T590 |
arg2Of |
shown,been |
R59202 |
T58379 |
T85598 |
arg1Of |
target,the |
R59233 |
T40498 |
T83531 |
arg1Of |
lack,on |
R593 |
T584 |
T591 |
arg2Of |
processing,shown |
R59320 |
T10070 |
T18896 |
arg1Of |
glycans,complex |
R59338 |
T86385 |
T80173 |
arg2Of |
4ZMJ,"," |
R59353 |
T99530 |
T57258 |
arg1Of |
analysis,of |
R59358 |
T33012 |
T31397 |
arg1Of |
Victoria,2011 |
R594 |
T593 |
T591 |
arg3Of |
be,shown |
R59455 |
T76353 |
T10053 |
arg2Of |
evolved,speculate |
R595 |
T593 |
T592 |
arg1Of |
be,to |
R59501 |
T74512 |
T22927 |
arg2Of |
PNGs,( |
R59560 |
T40157 |
T77923 |
arg2Of |
continually,than |
R596 |
T584 |
T593 |
arg1Of |
processing,be |
R59602 |
T40164 |
T19668 |
arg1Of |
materials,supplementary |
R59611 |
T9459 |
T8998 |
arg1Of |
application,patent |
R59613 |
T18714 |
T37792 |
arg1Of |
shield,of |
R59653 |
T84269 |
T39330 |
arg1Of |
efficacies,of |
R59667 |
T66936 |
T81346 |
arg1Of |
number,The |
R597 |
T596 |
T593 |
arg2Of |
reporter,be |
R59703 |
T85969 |
T63261 |
arg1Of |
dynamics,leads |
R59746 |
T82481 |
T93743 |
arg1Of |
subunit,to |
R59757 |
T50969 |
T94812 |
arg1Of |
limit,that |
R598 |
T596 |
T594 |
arg1Of |
reporter,a |
R59802 |
T20048 |
T56668 |
arg1Of |
response,the |
R59810 |
T99242 |
T67844 |
arg1Of |
head,of |
R59811 |
T92110 |
T70681 |
arg1Of |
glycans,N-linked |
R59857 |
T37762 |
T71933 |
arg1Of |
additions,glycan |
R59877 |
T17645 |
T39985 |
arg2Of |
sites,incorporated |
R599 |
T596 |
T595 |
arg1Of |
reporter,strong |
R59919 |
T40590 |
T34685 |
arg1Of |
area,and |
R59937 |
T9415 |
T52453 |
arg2Of |
variability,with |
R59957 |
T20048 |
T51090 |
arg1Of |
response,to |
R6 |
T7 |
T6 |
arg1Of |
glycosylation,extensive |
R60 |
T63 |
T64 |
arg1Of |
glycosylated,"," |
R600 |
T596 |
T597 |
arg1Of |
reporter,of |
R60000 |
T12458 |
T22396 |
arg1Of |
interests,Competing |
R60004 |
T23766 |
T92394 |
arg1Of |
reach,not |
R60028 |
T16399 |
T41174 |
arg2Of |
b,"," |
R60041 |
T20968 |
T22989 |
arg1Of |
and,"," |
R601 |
T600 |
T597 |
arg2Of |
architecture,of |
R60137 |
T20910 |
T72375 |
arg1Of |
antibodies,neutralizing |
R602 |
T600 |
T598 |
arg1Of |
architecture,native-like |
R60211 |
T68543 |
T61338 |
arg1Of |
glycoproteins,All |
R60221 |
T28749 |
T56558 |
arg1Of |
structures,Using |
R603 |
T600 |
T599 |
arg1Of |
architecture,protein |
R60328 |
T55295 |
T77211 |
arg1Of |
proteins,I |
R60366 |
T25304 |
T6148 |
arg2Of |
sequences,using |
R604 |
T591 |
T601 |
arg1Of |
shown,and |
R60416 |
T99373 |
T65467 |
arg2Of |
surfaces,as |
R60420 |
T28528 |
T53426 |
arg2Of |
measure,as |
R60460 |
T87593 |
T79382 |
arg1Of |
S41,and |
R605 |
T616 |
T601 |
arg2Of |
mimic,and |
R60505 |
T94035 |
T93804 |
arg1Of |
and,"," |
R60567 |
T66921 |
T48812 |
arg1Of |
they,are |
R606 |
T616 |
T602 |
arg1Of |
mimic,thus |
R60603 |
T13499 |
T59995 |
arg1Of |
differences,in |
R60609 |
T38215 |
T49022 |
arg1Of |
rates,higher |
R60619 |
T11163 |
T70780 |
arg2Of |
cells,in |
R607 |
T604 |
T603 |
arg1Of |
integrity36–38,immunogen |
R60748 |
T50771 |
T45372 |
arg1Of |
it,tempting |
R60765 |
T14682 |
T76353 |
arg1Of |
MERS,evolved |
R60780 |
T37031 |
T11037 |
arg1Of |
We,speculate |
R60786 |
T35915 |
T38149 |
arg1Of |
structure,of |
R60789 |
T15627 |
T64574 |
arg1Of |
nanobodies,which |
R608 |
T606 |
T605 |
arg1Of |
and,; |
R609 |
T604 |
T606 |
arg1Of |
integrity36–38,and |
R60972 |
T49009 |
T80667 |
arg1Of |
structure,defines |
R60976 |
T93024 |
T49839 |
arg3Of |
),( |
R60996 |
T89313 |
T61578 |
arg1Of |
much,of |
R60997 |
T88004 |
T67434 |
arg2Of |
mutants,of |
R61 |
T60 |
T65 |
arg1Of |
proteins,encoding |
R610 |
T608 |
T606 |
arg2Of |
processing,and |
R61028 |
T96423 |
T11954 |
arg1Of |
spikes,coronavirus |
R6106 |
T94857 |
T83825 |
arg2Of |
Mapping,indicate |
R611 |
T608 |
T607 |
arg1Of |
processing,glycan |
R61108 |
T68440 |
T57335 |
arg2Of |
example,For |
R6112 |
T38716 |
T18888 |
arg1Of |
note,interesting |
R61128 |
T66049 |
T52094 |
arg2Of |
shield,in |
R61132 |
T7541 |
T22232 |
arg1Of |
S,SARS |
R61179 |
T16712 |
T82163 |
arg2Of |
domains,of |
R612 |
T606 |
T609 |
arg1Of |
and,on |
R61214 |
T88390 |
T27490 |
arg1Of |
glycans,are |
R61258 |
T85671 |
T75169 |
arg2Of |
illustrated,is |
R613 |
T613 |
T609 |
arg2Of |
candidate,on |
R61334 |
T56514 |
T52338 |
arg1Of |
population,in |
R61336 |
T75554 |
T19065 |
arg1Of |
spikes,"," |
R614 |
T613 |
T610 |
arg1Of |
candidate,a |
R61408 |
T31427 |
T47095 |
arg2Of |
proteins,reduced |
R61420 |
T46703 |
T30395 |
arg1Of |
Cryo-EM,captures |
R61425 |
T84496 |
T37174 |
arg1Of |
S,SARS |
R61431 |
T81494 |
T44486 |
arg1Of |
resulting,in |
R61444 |
T17162 |
T49747 |
arg1Of |
colored,according |
R61463 |
T79412 |
T92980 |
arg1Of |
is,given |
R61464 |
T33263 |
T59798 |
arg2Of |
and,on |
R61476 |
T62928 |
T83472 |
arg1Of |
glycans,oligomannose-type |
R615 |
T613 |
T611 |
arg1Of |
candidate,successful |
R61523 |
T6621 |
T58427 |
arg1Of |
contribute,to |
R61542 |
T12473 |
T88293 |
arg2Of |
reduced,when |
R61550 |
T72037 |
T22099 |
arg1Of |
most,are |
R61571 |
T10175 |
T31210 |
arg1Of |
spectrometry,of |
R61595 |
T46492 |
T59632 |
arg1Of |
and,unable |
R616 |
T613 |
T612 |
arg1Of |
candidate,immunogen |
R61652 |
T88896 |
T74809 |
arg1Of |
code,is |
R61674 |
T15037 |
T22984 |
arg1Of |
shield,SARS |
R61681 |
T65633 |
T71210 |
arg1Of |
We,hypothesized |
R617 |
T606 |
T614 |
arg1Of |
and,should |
R61784 |
T84041 |
T30414 |
arg2Of |
Fig. 6,( |
R6179 |
T21366 |
T22927 |
arg1Of |
sites,( |
R618 |
T616 |
T614 |
arg2Of |
mimic,should |
R61821 |
T17864 |
T33234 |
arg2Of |
processing,of |
R61866 |
T1822 |
T94718 |
arg1Of |
is,as |
R619 |
T616 |
T615 |
arg1Of |
mimic,therefore |
R61959 |
T37271 |
T65959 |
arg1Of |
MSV000084993,( |
R61961 |
T53788 |
T5062 |
arg1Of |
functionality,be |
R62 |
T70 |
T65 |
arg2Of |
sites,encoding |
R620 |
T606 |
T616 |
arg1Of |
and,mimic |
R62064 |
T2440 |
T44594 |
arg1Of |
glycoproteins,a |
R62080 |
T8574 |
T5765 |
arg2Of |
highlighted,were |
R621 |
T625 |
T616 |
arg2Of |
features,mimic |
R62100 |
T79756 |
T38057 |
arg2Of |
diversification,of |
R62113 |
T28528 |
T85566 |
arg1Of |
measure,a |
R62161 |
T75213 |
T29294 |
arg1Of |
peptide,"," |
R62165 |
T34685 |
T92980 |
arg2Of |
and,given |
R62166 |
T96165 |
T75342 |
arg1Of |
residues,solvent-accessible |
R62189 |
T92063 |
T33696 |
arg2Of |
glycans,for |
R622 |
T616 |
T617 |
arg1Of |
mimic,"," |
R62239 |
T94571 |
T49839 |
arg1Of |
"procainamide24,45,53",( |
R62271 |
T49864 |
T25055 |
arg1Of |
glycans,and |
R623 |
T619 |
T618 |
arg1Of |
closely,as |
R62312 |
T38606 |
T35666 |
arg1Of |
GPC,which |
R6232 |
T72703 |
T32445 |
arg1Of |
levels,greater |
R62327 |
T83312 |
T36617 |
arg1Of |
construct,a |
R62340 |
T80844 |
T81018 |
arg1Of |
networks,are |
R62361 |
T29672 |
T95444 |
arg1Of |
datasets,available |
R624 |
T616 |
T619 |
arg1Of |
mimic,closely |
R62409 |
T83381 |
T82158 |
arg1Of |
glycosylation,extensive |
R62464 |
T35287 |
T14224 |
arg1Of |
virus,( |
R625 |
T619 |
T620 |
arg1Of |
closely,as |
R62502 |
T97769 |
T59510 |
arg1Of |
nextstrain61,( |
R62547 |
T32345 |
T33520 |
arg1Of |
environment,of |
R62598 |
T87240 |
T62278 |
arg1Of |
visualised,at |
R626 |
T621 |
T620 |
arg2Of |
possible,as |
R62630 |
T73114 |
T38418 |
arg1Of |
compare,directly |
R627 |
T616 |
T622 |
arg1Of |
mimic,"," |
R62725 |
T84653 |
T55443 |
arg1Of |
proteins,Viral |
R62729 |
T39465 |
T51236 |
arg2Of |
“shields”,of |
R62758 |
T4923 |
T44407 |
arg2Of |
inventors,are |
R628 |
T625 |
T623 |
arg1Of |
features,the |
R62810 |
T43357 |
T59397 |
arg1Of |
pressure,upon |
R62818 |
T74546 |
T93956 |
arg2Of |
investigated,have |
R62847 |
T91691 |
T94206 |
arg2Of |
how,showed |
R62864 |
T37921 |
T57424 |
arg2Of |
glycans,with |
R629 |
T625 |
T624 |
arg1Of |
features,structural |
R62907 |
T82408 |
T19013 |
arg1Of |
paper,this |
R62925 |
T54044 |
T91196 |
arg1Of |
evasion,immune |
R62926 |
T76564 |
T7134 |
arg1Of |
performed,subsequently |
R62985 |
T19555 |
T90413 |
arg1Of |
importance,be |
R63 |
T63 |
T65 |
modOf |
glycosylated,encoding |
R630 |
T625 |
T626 |
arg2Of |
features,observed |
R6303 |
T90192 |
T12725 |
arg1Of |
number,divided |
R63032 |
T31301 |
T42948 |
arg1Of |
and,respectively |
R63038 |
T13983 |
T10659 |
arg1Of |
arise,as |
R63070 |
T43199 |
T26807 |
arg2Of |
diversity,observed |
R63082 |
T80844 |
T70160 |
arg1Of |
networks,glycan |
R631 |
T626 |
T627 |
arg1Of |
observed,on |
R63130 |
T72317 |
T91868 |
arg1Of |
S,SARS |
R63181 |
T26958 |
T7859 |
arg2Of |
antibodies8,neutralising |
R632 |
T630 |
T627 |
arg2Of |
"virus39,40",on |
R6327 |
T88367 |
T51085 |
arg1Of |
levels,differential |
R63270 |
T59243 |
T48816 |
arg2Of |
SARS,and |
R63284 |
T83312 |
T53941 |
arg1Of |
construct,SOSIP.664 |
R633 |
T630 |
T628 |
arg1Of |
"virus39,40",the |
R63314 |
T24762 |
T46241 |
arg1Of |
glycoprotein,the |
R63316 |
T6621 |
T85630 |
arg1Of |
contribute,"," |
R634 |
T630 |
T629 |
arg1Of |
"virus39,40",native |
R63445 |
T8574 |
T92418 |
arg1Of |
highlighted,Furthermore |
R635 |
T652 |
T631 |
arg1Of |
and,Here |
R636 |
T652 |
T632 |
arg1Of |
and,"," |
R63626 |
T21664 |
T86817 |
arg1Of |
",","," |
R637 |
T633 |
T634 |
arg1Of |
we,provide |
R63756 |
T63979 |
T53700 |
arg1Of |
level,residue-specific |
R63791 |
T66354 |
T67807 |
arg1Of |
shielding,the |
R638 |
T638 |
T634 |
arg2Of |
analyses,provide |
R6382 |
T82683 |
T19897 |
arg2Of |
deposited,have |
R639 |
T638 |
T635 |
arg1Of |
analyses,global |
R6390 |
T94857 |
T13865 |
arg1Of |
Mapping,of |
R63943 |
T66049 |
T24478 |
arg1Of |
shield,effective |
R63988 |
T1830 |
T4468 |
arg1Of |
hinders,"," |
R64 |
T70 |
T66 |
arg1Of |
sites,around |
R640 |
T635 |
T636 |
arg1Of |
global,and |
R64002 |
T72369 |
T18378 |
arg1Of |
substitutions,( |
R641 |
T637 |
T636 |
arg2Of |
site-specific,and |
R64110 |
T88747 |
T37978 |
arg1Of |
observed,on |
R6412 |
T27017 |
T59510 |
arg2Of |
https,( |
R64143 |
T42122 |
T51626 |
arg2Of |
signal,to |
R64157 |
T97839 |
T15902 |
arg1Of |
note,is |
R64184 |
T91997 |
T72208 |
arg2Of |
SARS,of |
R642 |
T638 |
T637 |
arg1Of |
analyses,site-specific |
R64222 |
T26744 |
T52698 |
arg2Of |
viruses,of |
R64246 |
T20023 |
T60633 |
arg1Of |
reservoirs,natural |
R6426 |
T15042 |
T47642 |
arg3Of |
),( |
R64275 |
T99013 |
T67538 |
arg1Of |
Fig. 4,SI |
R64284 |
T33026 |
T67409 |
arg1Of |
glycans,released |
R643 |
T638 |
T639 |
arg1Of |
analyses,of |
R64301 |
T72051 |
T49737 |
arg1Of |
populations,complex-type |
R64305 |
T80559 |
T61778 |
arg2Of |
example,For |
R644 |
T641 |
T639 |
arg2Of |
glycosylation,of |
R64406 |
T53788 |
T92413 |
arg1Of |
functionality,of |
R6442 |
T63261 |
T50401 |
arg1Of |
leads,to |
R6444 |
T80082 |
T20638 |
arg1Of |
glycopeptides,were |
R64448 |
T49099 |
T83248 |
arg1Of |
domain,N-terminal |
R645 |
T641 |
T640 |
arg1Of |
glycosylation,N-linked |
R64546 |
T43156 |
T11597 |
arg1Of |
intervals,the |
R64553 |
T40276 |
T86408 |
arg1Of |
found,in |
R646 |
T634 |
T642 |
arg1Of |
provide,on |
R64614 |
T1963 |
T3743 |
arg1Of |
implicated,Importantly |
R64641 |
T5164 |
T60933 |
arg2Of |
modelling,illustrated |
R64648 |
T52910 |
T34630 |
arg1Of |
and,are |
R647 |
T647 |
T642 |
arg2Of |
and,on |
R64703 |
T43156 |
T18198 |
arg1Of |
intervals,highest |
R648 |
T644 |
T643 |
arg1Of |
SARS,soluble |
R64810 |
T75209 |
T86959 |
arg1Of |
ectodomain52,2P |
R64817 |
T15004 |
T1634 |
arg1Of |
region,this |
R64829 |
T30776 |
T73014 |
arg1Of |
S,( |
R649 |
T644 |
T645 |
arg1Of |
SARS,"," |
R64905 |
T64331 |
T42940 |
arg2Of |
ratios,had |
R6499 |
T11435 |
T35149 |
arg1Of |
advantage,a |
R64991 |
T38215 |
T48007 |
arg1Of |
rates,of |
R65 |
T70 |
T67 |
arg1Of |
sites,66–87 |
R650 |
T646 |
T645 |
arg2Of |
MERS,"," |
R65018 |
T56273 |
T13124 |
arg1Of |
map,cryo-EM |
R65034 |
T80657 |
T3932 |
arg1Of |
protein,I |
R6504 |
T10907 |
T31145 |
arg1Of |
Hybrid,& |
R65049 |
T4934 |
T30435 |
arg1Of |
responses,targeted |
R6505 |
T53788 |
T19398 |
arg1Of |
functionality,would |
R65072 |
T99864 |
T53301 |
arg1Of |
5X59,PDB |
R65080 |
T38496 |
T82041 |
arg2Of |
shield,would |
R651 |
T645 |
T647 |
arg1Of |
",",and |
R65134 |
T75718 |
T53208 |
arg1Of |
mapping,on |
R65141 |
T27344 |
T13320 |
arg2Of |
“2019-nCoV,( |
R65182 |
T38777 |
T20732 |
arg1Of |
densities,shield |
R65191 |
T73121 |
T64380 |
arg1Of |
whereas,that |
R65192 |
T52424 |
T33530 |
arg1Of |
Comparison,of |
R652 |
T651 |
T647 |
arg2Of |
glycoproteins,and |
R653 |
T651 |
T648 |
arg1Of |
glycoproteins,HKU1 |
R65335 |
T42677 |
T38584 |
arg2Of |
distribution,regarding |
R65398 |
T38606 |
T40144 |
arg2Of |
GPC,from |
R654 |
T651 |
T649 |
arg1Of |
glycoproteins,CoV |
R65480 |
T64096 |
T70981 |
arg1Of |
this,due |
R655 |
T651 |
T650 |
arg1Of |
glycoproteins,S |
R65513 |
T34685 |
T59451 |
arg1Of |
and,the |
R65530 |
T10448 |
T93438 |
arg1Of |
are,without |
R65536 |
T48265 |
T96495 |
arg1Of |
quantities,of |
R65540 |
T95182 |
T60590 |
arg1Of |
",",that |
R65597 |
T93319 |
T43420 |
arg2Of |
domains,and |
R656 |
T634 |
T652 |
arg1Of |
provide,and |
R65600 |
T39941 |
T50763 |
arg1Of |
genes,( |
R65608 |
T60790 |
T58919 |
arg2Of |
domains,and |
R65614 |
T90192 |
T62752 |
arg1Of |
number,of |
R65623 |
T37597 |
T88916 |
arg1Of |
data,only |
R6563 |
T68704 |
T47879 |
arg1Of |
exist,down |
R65669 |
T40780 |
T66900 |
arg2Of |
clusters,to |
R657 |
T653 |
T652 |
arg2Of |
reveal,and |
R65728 |
T84653 |
T43155 |
arg1Of |
proteins,are |
R65730 |
T36034 |
T38496 |
arg2Of |
epitopes,shield |
R65742 |
T26227 |
T61001 |
arg1Of |
abundance,mannose |
R658 |
T633 |
T653 |
arg1Of |
we,reveal |
R65830 |
T64906 |
T93681 |
arg1Of |
H1N1,HAs |
R65839 |
T76172 |
T86648 |
arg2Of |
immunization62–65,or |
R65847 |
T30265 |
T63067 |
arg2Of |
reproduced,were |
R65867 |
T51812 |
T21664 |
arg1Of |
trypsin,"," |
R659 |
T655 |
T653 |
arg2Of |
heterogeneity,reveal |
R65901 |
T68704 |
T33461 |
arg1Of |
exist,to |
R65942 |
T72051 |
T78484 |
arg1Of |
populations,glycan |
R65951 |
T75554 |
T68142 |
arg1Of |
spikes,would |
R65982 |
T74525 |
T27935 |
arg1Of |
but,"," |
R65984 |
T41472 |
T64701 |
arg1Of |
glycosylation,the |
R66 |
T70 |
T68 |
arg1Of |
sites,N-linked |
R660 |
T655 |
T654 |
arg1Of |
heterogeneity,extensive |
R66003 |
T99830 |
T26453 |
arg1Of |
hindered,sterically |
R66006 |
T2204 |
T69932 |
arg2Of |
sites,define |
R6605 |
T10370 |
T92947 |
arg1Of |
density,glycan |
R66074 |
T99824 |
T75223 |
arg2Of |
density,observe |
R661 |
T655 |
T656 |
arg1Of |
heterogeneity,"," |
R66138 |
T7534 |
T37469 |
arg2Of |
limits,and |
R66153 |
T56236 |
T84889 |
arg2Of |
b,"," |
R66179 |
T36278 |
T38160 |
arg1Of |
S,"," |
R66182 |
T16113 |
T98169 |
arg1Of |
panel,: |
R662 |
T655 |
T657 |
arg1Of |
heterogeneity,ranging |
R6622 |
T92070 |
T48648 |
arg1Of |
proteins,MERS |
R663 |
T657 |
T658 |
arg1Of |
ranging,from |
R66350 |
T43748 |
T42839 |
arg2Of |
structure,building |
R66356 |
T31010 |
T73372 |
arg1Of |
correlation,A |
R66372 |
T12725 |
T73735 |
arg2Of |
divided,was |
R664 |
T660 |
T658 |
arg2Of |
glycans,from |
R6643 |
T57392 |
T93684 |
arg1Of |
information,be |
R66468 |
T41135 |
T52094 |
arg1Of |
resulting,in |
R665 |
T660 |
T659 |
arg1Of |
glycans,oligomannose-type |
R666 |
T655 |
T661 |
arg1Of |
heterogeneity,to |
R66604 |
T31301 |
T29063 |
arg2Of |
and,( |
R66605 |
T52033 |
T63553 |
arg2Of |
proteases,of |
R66611 |
T49153 |
T64021 |
arg2Of |
density,blurred |
R6662 |
T64538 |
T59288 |
arg1Of |
notion,is |
R66651 |
T73192 |
T73414 |
arg1Of |
result,that |
R667 |
T664 |
T661 |
arg2Of |
glycosylation,to |
R668 |
T664 |
T662 |
arg1Of |
glycosylation,highly-processed |
R66839 |
T98451 |
T76352 |
arg1Of |
diversities,amino-acid |
R669 |
T664 |
T663 |
arg1Of |
glycosylation,complex-type |
R66915 |
T54061 |
T9629 |
arg2Of |
proteins,and |
R66917 |
T88390 |
T93818 |
arg1Of |
glycans,The |
R66919 |
T76860 |
T87041 |
arg2Of |
glycans,N-linked |
R66924 |
T99824 |
T59798 |
arg1Of |
density,on |
R66944 |
T11869 |
T12092 |
arg1Of |
sites,22 |
R66989 |
T81945 |
T17293 |
arg1Of |
MERS,and |
R67 |
T70 |
T69 |
arg1Of |
sites,glycosylation |
R670 |
T667 |
T665 |
arg1Of |
mapping,The |
R67033 |
T66915 |
T34488 |
arg1Of |
and,( |
R67041 |
T56105 |
T54764 |
arg1Of |
derived,from |
R67045 |
T80657 |
T27555 |
arg2Of |
protein,is |
R67091 |
T80023 |
T28342 |
arg1Of |
",",and |
R671 |
T667 |
T666 |
arg1Of |
mapping,structural |
R67128 |
T43073 |
T26917 |
arg1Of |
overlaid,simulated |
R67130 |
T69826 |
T87240 |
arg2Of |
glycoprotein,visualised |
R67157 |
T54008 |
T93591 |
arg2Of |
diversity,elevated |
R67171 |
T55295 |
T21676 |
arg1Of |
proteins,fusion |
R672 |
T667 |
T668 |
arg1Of |
mapping,of |
R67211 |
T77800 |
T76427 |
arg1Of |
analysis,Bioinformatic |
R67273 |
T30887 |
T77108 |
arg1Of |
are,"," |
R67277 |
T97014 |
T51212 |
arg1Of |
response,host |
R67284 |
T75679 |
T74428 |
arg1Of |
sequences,S |
R67285 |
T49302 |
T24919 |
arg2Of |
server,on |
R673 |
T669 |
T668 |
arg2Of |
glycans,of |
R67326 |
T43357 |
T38229 |
arg1Of |
pressure,immune |
R6736 |
T58945 |
T17558 |
arg1Of |
number,divided |
R67380 |
T42487 |
T38057 |
arg1Of |
evaluation,of |
R67385 |
T2696 |
T21250 |
arg2Of |
occluded,was |
R674 |
T669 |
T670 |
arg1Of |
glycans,of |
R67400 |
T15037 |
T97881 |
arg2Of |
shield,of |
R67426 |
T48129 |
T16400 |
arg1Of |
IgG,serum |
R67428 |
T66804 |
T80348 |
arg1Of |
surface,which |
R67493 |
T36034 |
T43430 |
arg1Of |
epitopes,that |
R675 |
T673 |
T670 |
arg2Of |
proteins,of |
R67521 |
T25542 |
T29000 |
arg1Of |
coverage,sparser |
R67544 |
T25653 |
T72137 |
arg2Of |
SARS-CoV-2,from |
R676 |
T673 |
T671 |
arg1Of |
proteins,trimeric |
R67642 |
T15037 |
T32877 |
arg1Of |
shield,glycan |
R67665 |
T14676 |
T9596 |
arg2Of |
53,of |
R67688 |
T51996 |
T78773 |
arg2Of |
calculated,were |
R677 |
T673 |
T672 |
arg1Of |
proteins,S |
R67744 |
T46398 |
T12832 |
arg1Of |
were,Although |
R67783 |
T8069 |
T66117 |
arg1Of |
glycan28,the |
R67792 |
T58510 |
T94740 |
arg1Of |
level,contour |
R67799 |
T59734 |
T82162 |
arg1Of |
constraints,as |
R678 |
T667 |
T674 |
arg1Of |
mapping,revealed |
R6781 |
T66804 |
T27513 |
arg1Of |
surface,and |
R67815 |
T69025 |
T9637 |
arg1Of |
analysis,and |
R67827 |
T10989 |
T79574 |
arg1Of |
"response21,31",host |
R67847 |
T61476 |
T43495 |
arg1Of |
residues,of |
R679 |
T680 |
T674 |
arg2Of |
contribute,revealed |
R67918 |
T34663 |
T28338 |
arg1Of |
observed,on |
R6796 |
T85214 |
T29063 |
arg1Of |
and,( |
R67963 |
T54943 |
T78450 |
arg1Of |
coronavirus,this |
R68 |
T70 |
T71 |
arg1Of |
sites,per |
R680 |
T680 |
T675 |
arg1Of |
contribute,that |
R6800 |
T2450 |
T43383 |
arg1Of |
Env,HIV-1 |
R68081 |
T78585 |
T27968 |
arg1Of |
2.82,for |
R681 |
T676 |
T677 |
arg1Of |
some,of |
R68137 |
T88882 |
T23715 |
arg2Of |
subject,are |
R68158 |
T15422 |
T10462 |
arg1Of |
surface,the |
R682 |
T679 |
T677 |
arg2Of |
glycans,of |
R68204 |
T3893 |
T10724 |
modOf |
shown,leading |
R683 |
T679 |
T678 |
arg1Of |
glycans,these |
R68310 |
T36034 |
T42643 |
arg1Of |
epitopes,are |
R68327 |
T68539 |
T70877 |
arg1Of |
glycans,oligomannose-type |
R68351 |
T40498 |
T81866 |
arg1Of |
lack,of |
R684 |
T676 |
T680 |
arg1Of |
some,contribute |
R68437 |
T77577 |
T6892 |
arg1Of |
observed,likely |
R68459 |
T90192 |
T71326 |
arg2Of |
number,by |
R68476 |
T10370 |
T81164 |
arg1Of |
density,shield |
R68490 |
T14361 |
T7384 |
arg1Of |
outbreak,each |
R685 |
T680 |
T681 |
arg1Of |
contribute,to |
R68581 |
T29096 |
T16612 |
arg1Of |
modifications,post-translational |
R68588 |
T61586 |
T97416 |
arg3Of |
),( |
R68593 |
T81297 |
T37643 |
arg2Of |
surface,of |
R686 |
T683 |
T681 |
arg2Of |
formation,to |
R6860 |
T10324 |
T58779 |
arg1Of |
ratios,dN/dS |
R68611 |
T60774 |
T35369 |
arg1Of |
sites,glycosylation |
R68632 |
T70323 |
T33888 |
arg1Of |
proteins,( |
R6866 |
T69286 |
T16556 |
arg2Of |
calculated,was |
R68677 |
T35584 |
T85948 |
arg2Of |
functionality,perturbing |
R687 |
T683 |
T682 |
arg1Of |
formation,the |
R6872 |
T91463 |
T37758 |
arg1Of |
coming,from |
R688 |
T683 |
T684 |
arg1Of |
formation,of |
R68812 |
T78881 |
T64135 |
arg1Of |
4O5N,"," |
R68851 |
T2961 |
T14475 |
arg1Of |
had,"," |
R68855 |
T32211 |
T57010 |
arg1Of |
elicit,"," |
R689 |
T686 |
T684 |
arg2Of |
cluster,of |
R68909 |
T18648 |
T40659 |
arg1Of |
interactions,glycan–glycan |
R68911 |
T18913 |
T82055 |
arg2Of |
HIV-1,as |
R68916 |
T66804 |
T90504 |
arg1Of |
surface,serve |
R69 |
T73 |
T71 |
arg2Of |
spike,per |
R690 |
T686 |
T685 |
arg1Of |
cluster,a |
R69033 |
T66049 |
T41086 |
arg1Of |
shield,an |
R69064 |
T66354 |
T51052 |
arg2Of |
shielding,observed |
R69077 |
T68204 |
T55529 |
arg1Of |
measured,in |
R69083 |
T93400 |
T11696 |
arg1Of |
N-linked,Quantitative |
R691 |
T686 |
T687 |
arg1Of |
cluster,of |
R69107 |
T82951 |
T16903 |
arg1Of |
hallmark,of |
R69140 |
T72195 |
T31422 |
arg2Of |
recognition,in |
R692 |
T689 |
T687 |
arg2Of |
glycans,of |
R69204 |
T8708 |
T54589 |
arg2Of |
importance,underscores |
R69282 |
T4404 |
T32963 |
arg2Of |
and,of |
R693 |
T689 |
T688 |
arg1Of |
glycans,oligomannose-type |
R69300 |
T23381 |
T45120 |
arg2Of |
0.10,of |
R69352 |
T60790 |
T18570 |
arg1Of |
domains,receptor-binding |
R69367 |
T28749 |
T33039 |
arg1Of |
structures,of |
R69392 |
T57392 |
T49504 |
arg1Of |
information,Additional |
R694 |
T680 |
T690 |
arg1Of |
contribute,at |
R69414 |
T56273 |
T66412 |
arg1Of |
map,with |
R69440 |
T73114 |
T8410 |
arg1Of |
compare,in |
R69444 |
T8512 |
T57382 |
arg1Of |
coronaviruses,several |
R69466 |
T73114 |
T80633 |
arg1Of |
compare,difficult |
R6949 |
T82481 |
T80845 |
arg2Of |
subunit,on |
R69492 |
T32211 |
T29228 |
arg1Of |
elicit,on |
R695 |
T692 |
T690 |
arg2Of |
regions,at |
R69540 |
T96551 |
T87992 |
arg2Of |
MERS,and |
R69562 |
T21025 |
T24463 |
arg1Of |
abundances,of |
R696 |
T692 |
T691 |
arg1Of |
regions,specific |
R69613 |
T2320 |
T64649 |
arg2Of |
addition,In |
R69625 |
T68609 |
T42572 |
arg2Of |
structures,onto |
R69629 |
T13786 |
T34488 |
arg2Of |
Fig. 3a,( |
R6966 |
T58919 |
T51281 |
arg2Of |
and,as |
R697 |
T692 |
T693 |
arg1Of |
regions,of |
R69725 |
T35287 |
T82138 |
arg1Of |
virus,immunodeficiency |
R69771 |
T21845 |
T37792 |
arg2Of |
"HIV-120,39",of |
R69778 |
T54786 |
T20256 |
arg1Of |
"research22,60",influenza |
R698 |
T696 |
T693 |
arg2Of |
density,of |
R69824 |
T44407 |
T49061 |
arg1Of |
are,no |
R69846 |
T56245 |
T18704 |
arg1Of |
antibodies,single-domain |
R6985 |
T34602 |
T68570 |
arg1Of |
structuring,higher-order |
R69863 |
T23766 |
T88529 |
arg2Of |
reach,does |
R69877 |
T54786 |
T66965 |
arg2Of |
"research22,60",during |
R699 |
T696 |
T694 |
arg1Of |
density,high |
R69922 |
T80639 |
T40837 |
arg1Of |
diversity,elevated |
R69926 |
T46208 |
T14534 |
arg2Of |
spikes,of |
R69930 |
T82137 |
T96908 |
arg2Of |
compositions,based |
R6998 |
T69625 |
T60843 |
arg1Of |
study,this |
R69986 |
T60437 |
T64573 |
arg1Of |
total,a |
R69989 |
T8574 |
T21020 |
arg1Of |
highlighted,on |
R7 |
T12 |
T9 |
arg1Of |
syndrome,Severe |
R70 |
T73 |
T72 |
arg1Of |
spike,trimeric |
R700 |
T696 |
T695 |
arg1Of |
density,glycan |
R70015 |
T55170 |
T30720 |
arg2Of |
inhibition,from |
R70039 |
T11869 |
T97157 |
arg1Of |
sites,glycan |
R70051 |
T63244 |
T77547 |
arg2Of |
mutations,of |
R7009 |
T55170 |
T33234 |
arg1Of |
inhibition,of |
R701 |
T680 |
T697 |
arg1Of |
contribute,on |
R70110 |
T1963 |
T31422 |
arg1Of |
implicated,in |
R70125 |
T91715 |
T58888 |
arg1Of |
glycoproteins,including |
R702 |
T710 |
T697 |
arg2Of |
reveals,on |
R7026 |
T75621 |
T84066 |
arg1Of |
interacting,with |
R70293 |
T65616 |
T81755 |
arg1Of |
circles,the |
R70296 |
T59603 |
T92287 |
arg2Of |
values,exhibited |
R703 |
T700 |
T698 |
arg1Of |
Molecular,MERS-CoV |
R7031 |
T37271 |
T59257 |
arg2Of |
MSV000084993,: |
R70336 |
T80633 |
T32700 |
arg2Of |
difficult,is |
R704 |
T700 |
T699 |
arg1Of |
Molecular,S. |
R70463 |
T12931 |
T36239 |
arg2Of |
Env,for |
R70477 |
T68609 |
T73775 |
arg1Of |
structures,of |
R705 |
T702 |
T700 |
arg1Of |
analysis,Molecular |
R706 |
T702 |
T701 |
arg1Of |
analysis,evolution |
R70606 |
T93347 |
T2438 |
arg1Of |
of,as |
R70659 |
T12419 |
T16685 |
arg1Of |
there,is |
R70679 |
T80657 |
T20248 |
arg1Of |
protein,prototypic |
R70687 |
T26306 |
T52822 |
arg1Of |
we,visualize |
R707 |
T702 |
T703 |
arg1Of |
analysis,of |
R70729 |
T72317 |
T2448 |
arg1Of |
S,( |
R70746 |
T1830 |
T60855 |
arg1Of |
hinders,In |
R70752 |
T40602 |
T56201 |
arg2Of |
Use”,and |
R70770 |
T53788 |
T99830 |
arg2Of |
functionality,hindered |
R708 |
T708 |
T703 |
arg2Of |
genes,of |
R70838 |
T52910 |
T48779 |
arg2Of |
and,indicated |
R70842 |
T24412 |
T2009 |
arg1Of |
limit,to |
R709 |
T708 |
T704 |
arg1Of |
genes,SARS |
R7092 |
T92271 |
T59290 |
arg1Of |
rate66,and |
R70932 |
T11314 |
T53947 |
arg2Of |
Env,exposed |
R70962 |
T67622 |
T58043 |
arg1Of |
values,dN/dS |
R70972 |
T51290 |
T93380 |
arg1Of |
are,and |
R71 |
T77 |
T74 |
arg1Of |
reveal,Here |
R710 |
T704 |
T705 |
arg1Of |
SARS,and |
R71016 |
T66750 |
T8001 |
arg1Of |
compared,"," |
R71053 |
T61369 |
T85886 |
arg1Of |
ratio,of |
R71079 |
T89551 |
T98213 |
arg2Of |
offer,may |
R711 |
T706 |
T705 |
arg2Of |
MERS,and |
R71132 |
T60774 |
T58850 |
arg2Of |
sites,of |
R71165 |
T1508 |
T66208 |
arg1Of |
boundaries,between |
R712 |
T708 |
T706 |
arg1Of |
genes,MERS |
R71202 |
T60933 |
T74928 |
arg1Of |
illustrated,on |
R7121 |
T62404 |
T50573 |
arg2Of |
100,and |
R71233 |
T28749 |
T31179 |
arg1Of |
structures,and |
R71256 |
T83312 |
T48004 |
arg2Of |
construct,in |
R71285 |
T66915 |
T31759 |
arg2Of |
and,at |
R713 |
T708 |
T707 |
arg1Of |
genes,S |
R71341 |
T14194 |
T78202 |
arg1Of |
glycosylation,the |
R71348 |
T1670 |
T57479 |
arg1Of |
trimming,of |
R71368 |
T52825 |
T10378 |
arg2Of |
glycans,recognise |
R71369 |
T74525 |
T25050 |
arg1Of |
but,"," |
R714 |
T710 |
T709 |
arg1Of |
reveals,also |
R71428 |
T85689 |
T12542 |
arg1Of |
proportion,a |
R71448 |
T88912 |
T15821 |
arg1Of |
compared,in |
R71487 |
T83032 |
T99058 |
arg1Of |
is,As |
R715 |
T702 |
T710 |
arg1Of |
analysis,reveals |
R71509 |
T72051 |
T75452 |
arg1Of |
populations,( |
R71520 |
T35915 |
T26156 |
arg1Of |
structure,prefusion |
R71539 |
T54609 |
T31759 |
arg1Of |
glycans,at |
R71549 |
T26594 |
T1758 |
arg2Of |
had,as |
R71577 |
T82290 |
T73267 |
arg2Of |
and,for |
R71588 |
T79420 |
T49752 |
arg3Of |
),( |
R716 |
T713 |
T710 |
arg2Of |
incidence,reveals |
R71622 |
T82870 |
T67844 |
arg2Of |
protein,of |
R71664 |
T85671 |
T14723 |
arg1Of |
illustrated,on |
R71690 |
T86793 |
T11216 |
arg2Of |
epitopes,reduced |
R717 |
T713 |
T711 |
arg1Of |
incidence,a |
R71719 |
T94035 |
T25861 |
arg1Of |
and,respectively |
R71746 |
T85021 |
T19591 |
arg1Of |
outbreaks,SARS |
R718 |
T713 |
T712 |
arg1Of |
incidence,higher |
R71846 |
T19557 |
T1830 |
arg2Of |
differ,hinders |
R719 |
T713 |
T714 |
arg1Of |
incidence,of |
R71914 |
T92910 |
T85890 |
arg1Of |
Residues,are |
R71969 |
T42372 |
T72419 |
arg1Of |
S,MERS |
R71972 |
T75781 |
T1970 |
arg2Of |
up,in |
R72 |
T77 |
T75 |
arg1Of |
reveal,"," |
R720 |
T716 |
T714 |
arg2Of |
diversity,of |
R72021 |
T17681 |
T73974 |
arg1Of |
candidates,vaccine |
R721 |
T716 |
T715 |
arg1Of |
diversity,amino-acid |
R7210 |
T12203 |
T85444 |
arg1Of |
spike,the |
R72145 |
T60681 |
T14534 |
arg1Of |
diversification,of |
R72163 |
T25542 |
T85581 |
arg1Of |
coverage,over |
R722 |
T710 |
T717 |
arg1Of |
reveals,on |
R72203 |
T20594 |
T7753 |
arg1Of |
residues,would |
R72204 |
T7879 |
T44958 |
arg1Of |
structure,ensemble-average |
R72278 |
T60433 |
T34895 |
arg1Of |
calculated,and |
R72281 |
T67487 |
T69929 |
arg2Of |
and,whereas |
R723 |
T720 |
T717 |
arg2Of |
surfaces,on |
R72305 |
T45067 |
T82922 |
arg1Of |
glycans,on |
R72328 |
T71179 |
T58601 |
arg3Of |
),( |
R72329 |
T39966 |
T95730 |
arg3Of |
),( |
R72365 |
T50573 |
T63910 |
arg2Of |
and,( |
R724 |
T720 |
T718 |
arg1Of |
surfaces,the |
R7241 |
T2450 |
T74217 |
arg1Of |
Env,and |
R72417 |
T75525 |
T55713 |
arg2Of |
“shield”,of |
R72438 |
T26477 |
T2107 |
arg1Of |
Left,to |
R72441 |
T95298 |
T19490 |
arg1Of |
copies,of |
R72485 |
T18666 |
T45711 |
arg1Of |
spectrometry,( |
R72489 |
T18714 |
T46337 |
arg1Of |
shield,the |
R725 |
T720 |
T719 |
arg2Of |
surfaces,exposed |
R72593 |
T58857 |
T6148 |
arg1Of |
we,using |
R726 |
T720 |
T721 |
arg1Of |
surfaces,of |
R72605 |
T42677 |
T17537 |
arg1Of |
distribution,the |
R72618 |
T1822 |
T46731 |
modOf |
is,Given |
R727 |
T724 |
T721 |
arg2Of |
proteins,of |
R72732 |
T23968 |
T83864 |
arg2Of |
exhibits,whereas |
R7274 |
T99824 |
T87308 |
arg1Of |
density,all-encompassing |
R72746 |
T90081 |
T8587 |
arg2Of |
exhibit,did |
R72750 |
T33026 |
T62295 |
arg2Of |
glycans,of |
R72760 |
T32211 |
T2480 |
arg1Of |
elicit,following |
R72771 |
T38606 |
T56105 |
arg2Of |
GPC,derived |
R728 |
T724 |
T722 |
arg1Of |
proteins,the |
R72861 |
T55109 |
T1585 |
arg1Of |
solvent-accessible,"," |
R729 |
T724 |
T723 |
arg1Of |
proteins,S |
R72909 |
T45911 |
T72556 |
arg2Of |
S,of |
R72931 |
T19555 |
T93956 |
arg1Of |
importance,have |
R72941 |
T54943 |
T70467 |
arg1Of |
coronavirus,novel |
R72983 |
T95089 |
T28342 |
arg2Of |
volume,and |
R72986 |
T68523 |
T71413 |
arg2Of |
and,of |
R72995 |
T20968 |
T70083 |
arg2Of |
and,of |
R73 |
T76 |
T77 |
arg1Of |
we,reveal |
R730 |
T720 |
T725 |
arg1Of |
surfaces,that |
R7301 |
T72369 |
T63573 |
arg1Of |
substitutions,nucleotide |
R7304 |
T14141 |
T67059 |
arg1Of |
presence,The |
R73049 |
T75995 |
T33346 |
arg1Of |
observed,for |
R73081 |
T64999 |
T53746 |
arg2Of |
23,with |
R731 |
T720 |
T726 |
arg1Of |
surfaces,are |
R73107 |
T62928 |
T57941 |
arg1Of |
glycans,the |
R73123 |
T27860 |
T14782 |
arg1Of |
events,from |
R732 |
T728 |
T726 |
arg2Of |
occluded,are |
R73216 |
T81512 |
T55641 |
arg1Of |
18,of |
R73217 |
T13277 |
T54555 |
arg2Of |
all,at |
R73294 |
T65176 |
T93347 |
arg1Of |
n = 566,of |
R73297 |
T75554 |
T16194 |
arg1Of |
spikes,which |
R733 |
T728 |
T727 |
arg1Of |
occluded,not |
R7333 |
T67409 |
T58794 |
arg1Of |
released,F |
R7338 |
T54866 |
T84066 |
arg2Of |
glycans,with |
R734 |
T731 |
T728 |
arg1Of |
glycans,occluded |
R73400 |
T34602 |
T35212 |
arg1Of |
structuring,in |
R7341 |
T2440 |
T57258 |
arg2Of |
glycoproteins,of |
R73473 |
T30435 |
T66630 |
arg2Of |
targeted,be |
R73479 |
T3337 |
T25513 |
arg1Of |
shield51,the |
R735 |
T720 |
T728 |
arg2Of |
surfaces,occluded |
R73554 |
T98112 |
T45765 |
arg1Of |
domain,the |
R73569 |
T67026 |
T98351 |
arg1Of |
domains,in |
R736 |
T731 |
T729 |
arg2Of |
glycans,by |
R73678 |
T90081 |
T74525 |
arg1Of |
exhibit,but |
R737 |
T731 |
T730 |
arg1Of |
glycans,N-linked |
R73701 |
T80500 |
T12634 |
arg2Of |
residues,buried |
R73752 |
T83020 |
T70902 |
arg1Of |
presence,plays |
R73775 |
T27072 |
T4572 |
arg1Of |
Env49,HIV-1 |
R738 |
T746 |
T732 |
arg1Of |
and,In |
R73807 |
T77577 |
T83032 |
arg1Of |
observed,is |
R7381 |
T39941 |
T80371 |
arg1Of |
genes,SARS-CoV-2 |
R73831 |
T37762 |
T91373 |
arg1Of |
additions,and |
R73887 |
T51449 |
T56776 |
arg1Of |
proteins,I |
R739 |
T733 |
T732 |
arg2Of |
addition,In |
R73901 |
T32624 |
T63332 |
arg1Of |
diversity,sequence |
R73995 |
T15044 |
T73857 |
arg2Of |
and,convolved |
R74 |
T80 |
T77 |
arg2Of |
area,reveal |
R740 |
T746 |
T734 |
arg1Of |
and,"," |
R74093 |
T75003 |
T8482 |
arg1Of |
data,raw |
R74094 |
T74143 |
T2361 |
arg1Of |
density,the |
R741 |
T735 |
T736 |
arg1Of |
we,compare |
R74108 |
T65172 |
T14314 |
arg1Of |
domain,receptor-binding |
R74158 |
T79747 |
T37495 |
arg1Of |
key,the |
R74168 |
T56514 |
T9118 |
arg1Of |
population,oligomannose-type |
R742 |
T738 |
T736 |
arg2Of |
structures,compare |
R74212 |
T32200 |
T30461 |
arg1Of |
antibodies,neutralizing |
R74218 |
T58510 |
T22530 |
arg2Of |
level,at |
R74249 |
T73688 |
T68517 |
arg1Of |
effects,shielding |
R74251 |
T87992 |
T29922 |
arg2Of |
and,for |
R743 |
T738 |
T737 |
arg1Of |
structures,the |
R74388 |
T55814 |
T51235 |
arg1Of |
and,upon |
R7439 |
T13006 |
T89961 |
arg1Of |
sites,glycosylation |
R74391 |
T20048 |
T80278 |
arg2Of |
response,in |
R74395 |
T37597 |
T10901 |
arg1Of |
data,of |
R744 |
T738 |
T739 |
arg1Of |
structures,of |
R74402 |
T93322 |
T68214 |
arg1Of |
context,structural |
R74494 |
T43073 |
T22579 |
arg2Of |
overlaid,with |
R74499 |
T83825 |
T2785 |
arg2Of |
indicate,while |
R745 |
T743 |
T739 |
arg2Of |
coats,of |
R74540 |
T96423 |
T90159 |
arg2Of |
spikes,of |
R74579 |
T25133 |
T64136 |
arg3Of |
pink,dashed |
R746 |
T743 |
T740 |
arg1Of |
coats,the |
R74679 |
T94405 |
T76643 |
arg1Of |
model,of |
R747 |
T743 |
T741 |
arg1Of |
coats,respective |
R74774 |
T14190 |
T8187 |
arg1Of |
analysis,3D |
R748 |
T743 |
T742 |
arg1Of |
coats,glycan |
R74870 |
T1468 |
T1478 |
arg1Of |
highlight,and |
R749 |
T743 |
T744 |
arg1Of |
coats,of |
R74950 |
T29035 |
T95898 |
arg1Of |
Comparison,b |
R74985 |
T33026 |
T78639 |
arg1Of |
glycans,PNGase |
R74990 |
T61088 |
T96660 |
arg1Of |
targeted,and |
R75 |
T80 |
T78 |
arg1Of |
area,a |
R750 |
T745 |
T744 |
arg2Of |
SARS,of |
R75062 |
T73464 |
T90139 |
arg2Of |
library,generated |
R751 |
T736 |
T746 |
arg1Of |
compare,and |
R7514 |
T1932 |
T96910 |
arg1Of |
glycoproteins,viral |
R75170 |
T88896 |
T50409 |
arg1Of |
code,available |
R75191 |
T90504 |
T9316 |
arg2Of |
serve,can |
R752 |
T766 |
T746 |
arg2Of |
exhibited,and |
R75268 |
T55216 |
T15548 |
arg1Of |
We,would |
R753 |
T749 |
T747 |
arg1Of |
proteins,HIV-1 |
R75383 |
T75003 |
T35189 |
arg1Of |
data,spectrometric |
R754 |
T749 |
T748 |
arg1Of |
proteins,envelope |
R75418 |
T11621 |
T31174 |
arg1Of |
offer,against |
R75492 |
T6464 |
T51710 |
arg1Of |
",","," |
R755 |
T749 |
T750 |
arg1Of |
proteins,using |
R75510 |
T51449 |
T13008 |
arg2Of |
proteins,of |
R75547 |
T81925 |
T11525 |
arg1Of |
proteins,S |
R75548 |
T66936 |
T36773 |
arg1Of |
number,of |
R756 |
T756 |
T750 |
arg2Of |
and,using |
R75613 |
T76651 |
T63553 |
arg1Of |
assortment,of |
R75632 |
T88390 |
T93961 |
arg2Of |
glycans,colored |
R7569 |
T96185 |
T74217 |
arg2Of |
"GPC24,31,34,36,45,46",and |
R75695 |
T79747 |
T30404 |
arg2Of |
key,by |
R75698 |
T75781 |
T91066 |
arg1Of |
up,both |
R757 |
T752 |
T751 |
arg1Of |
microscopy,cryo-electron |
R75703 |
T66013 |
T67487 |
arg1Of |
appear,and |
R75722 |
T59672 |
T90413 |
arg2Of |
considered,be |
R75726 |
T48991 |
T34520 |
arg2Of |
Fig. 4a,( |
R75729 |
T71146 |
T85890 |
arg2Of |
colored,are |
R7575 |
T64331 |
T56294 |
arg1Of |
ratios,mean |
R7577 |
T19207 |
T62312 |
arg3Of |
),( |
R75794 |
T94055 |
T84292 |
arg2Of |
comparisons,of |
R75798 |
T85021 |
T62735 |
arg2Of |
outbreaks,and |
R758 |
T752 |
T753 |
arg1Of |
microscopy,( |
R75856 |
T42577 |
T48803 |
arg1Of |
modulation,of |
R75872 |
T59830 |
T17878 |
arg1Of |
elevated,significantly |
R759 |
T754 |
T753 |
arg2Of |
cryo-EM,( |
R75905 |
T35287 |
T35124 |
arg1Of |
virus,MERS |
R75933 |
T77577 |
T56317 |
arg1Of |
observed,it |
R75968 |
T5466 |
T11453 |
arg2Of |
glycans,with |
R75973 |
T96165 |
T84433 |
arg2Of |
residues,of |
R76 |
T80 |
T79 |
arg1Of |
area,specific |
R760 |
T755 |
T753 |
arg3Of |
),( |
R76012 |
T27050 |
T31852 |
arg1Of |
microscopy,single-particle |
R761 |
T752 |
T756 |
arg1Of |
microscopy,and |
R76131 |
T87240 |
T22579 |
arg1Of |
visualised,with |
R76144 |
T61476 |
T62752 |
arg2Of |
residues,of |
R76150 |
T77577 |
T80845 |
arg1Of |
observed,on |
R76166 |
T18714 |
T52476 |
arg1Of |
shield,evolving |
R76178 |
T78169 |
T64492 |
arg2Of |
N166A,"," |
R76184 |
T52424 |
T60202 |
arg1Of |
Comparison,Fig. |
R76187 |
T15627 |
T44925 |
arg1Of |
nanobodies,camel |
R762 |
T758 |
T756 |
arg2Of |
modelling,and |
R76229 |
T67457 |
T72214 |
arg3Of |
),( |
R76231 |
T63979 |
T83914 |
arg1Of |
level,a |
R76273 |
T82137 |
T30425 |
arg1Of |
compositions,are |
R76283 |
T43156 |
T41089 |
arg2Of |
intervals,to |
R763 |
T758 |
T757 |
arg1Of |
modelling,computational |
R7635 |
T90188 |
T68941 |
arg1Of |
map,Low-pass |
R76365 |
T35124 |
T37894 |
arg1Of |
MERS,glycosylated |
R76378 |
T58864 |
T59844 |
arg2Of |
diversity,to |
R764 |
T758 |
T759 |
arg1Of |
modelling,"," |
R76401 |
T15627 |
T31174 |
arg2Of |
nanobodies,against |
R76412 |
T40801 |
T85225 |
arg1Of |
are,Although |
R76425 |
T10224 |
T41739 |
arg1Of |
MERS,trimeric |
R76452 |
T81231 |
T72942 |
arg2Of |
considered,can |
R76492 |
T44204 |
T82222 |
arg1Of |
//massive.ucsd.edu,with |
R765 |
T758 |
T760 |
arg1Of |
modelling,which |
R76558 |
T48004 |
T52255 |
arg1Of |
in,as |
R76563 |
T30576 |
T94991 |
arg1Of |
S,SARS |
R7658 |
T58744 |
T10901 |
arg2Of |
quality,of |
R76589 |
T39985 |
T77299 |
arg2Of |
incorporated,be |
R766 |
T758 |
T761 |
arg1Of |
modelling,delineate |
R76630 |
T13582 |
T53208 |
arg2Of |
and,on |
R76646 |
T3759 |
T24472 |
arg2Of |
S,of |
R76670 |
T94857 |
T97958 |
arg1Of |
Mapping,c |
R76672 |
T4098 |
T79086 |
arg2Of |
Fig. 6,( |
R767 |
T765 |
T761 |
arg2Of |
shield,delineate |
R76705 |
T83410 |
T85418 |
arg2Of |
Fig. 3a,( |
R768 |
T765 |
T762 |
arg1Of |
shield,a |
R76809 |
T38543 |
T91973 |
arg1Of |
glycosylated,but |
R76821 |
T49153 |
T52169 |
arg2Of |
density,in |
R769 |
T765 |
T763 |
arg1Of |
shield,sparse |
R76910 |
T74921 |
T5294 |
arg1Of |
panel,: |
R76941 |
T7541 |
T94235 |
arg2Of |
S,on |
R76944 |
T10989 |
T94198 |
arg1Of |
"response21,31",immune |
R77 |
T80 |
T81 |
arg1Of |
area,of |
R770 |
T765 |
T764 |
arg1Of |
shield,glycan |
R77034 |
T39672 |
T1585 |
arg2Of |
amino-acid,"," |
R77082 |
T65417 |
T71938 |
arg1Of |
differ,significantly |
R771 |
T749 |
T766 |
arg1Of |
proteins,exhibited |
R77147 |
T65942 |
T19490 |
arg2Of |
Fabs51,of |
R77188 |
T75003 |
T20416 |
arg1Of |
data,support |
R772 |
T769 |
T766 |
arg2Of |
S,exhibited |
R77296 |
T58857 |
T3483 |
arg1Of |
we,performed |
R773 |
T766 |
T767 |
arg1Of |
exhibited,on |
R7735 |
T28741 |
T30776 |
arg1Of |
mapping,S |
R774 |
T768 |
T767 |
arg2Of |
SARS,on |
R77404 |
T3174 |
T27555 |
arg1Of |
Env,is |
R77410 |
T34000 |
T54890 |
arg1Of |
receptor-binding,and |
R77417 |
T35201 |
T72056 |
arg1Of |
reflected,in |
R775 |
T766 |
T770 |
arg1Of |
exhibited,compared |
R77574 |
T65417 |
T56277 |
arg1Of |
differ,depending |
R77591 |
T15804 |
T55323 |
arg1Of |
elicit,to |
R776 |
T771 |
T770 |
arg2Of |
with,compared |
R77630 |
T95497 |
T33229 |
arg2Of |
in,being |
R777 |
T774 |
T771 |
arg2Of |
glycoproteins,with |
R77726 |
T53788 |
T63119 |
arg1Of |
functionality,that |
R77739 |
T30887 |
T45174 |
arg1Of |
are,Furthermore |
R77752 |
T13646 |
T61859 |
arg2Of |
glycoprotein,of |
R77760 |
T21302 |
T92374 |
arg1Of |
shields,HIV-1 |
R77763 |
T54724 |
T72837 |
arg2Of |
mapped,were |
R77783 |
T80500 |
T77635 |
arg1Of |
residues,on |
R77790 |
T15044 |
T7534 |
arg1Of |
and,limits |
R778 |
T774 |
T772 |
arg1Of |
glycoproteins,other |
R77813 |
T47879 |
T44006 |
arg2Of |
down,and |
R77821 |
T44762 |
T45752 |
arg2Of |
labelled,were |
R77886 |
T14190 |
T89162 |
arg2Of |
analysis,as |
R77888 |
T95787 |
T67617 |
arg2Of |
number,by |
R779 |
T774 |
T773 |
arg1Of |
glycoproteins,viral |
R77907 |
T89313 |
T10630 |
arg1Of |
much,as |
R77919 |
T72666 |
T68472 |
arg2Of |
approach,using |
R77925 |
T13523 |
T88928 |
arg2Of |
glycans,of |
R77938 |
T2354 |
T99079 |
arg1Of |
subunit,the |
R78 |
T84 |
T81 |
arg2Of |
density,of |
R780 |
T777 |
T776 |
arg1Of |
undertook,therefore |
R78036 |
T80993 |
T47375 |
modOf |
mutagenesis,to |
R78049 |
T6629 |
T90729 |
arg1Of |
compositions,glycan |
R78062 |
T37271 |
T97993 |
arg1Of |
MSV000084993,for |
R78066 |
T15412 |
T19099 |
arg1Of |
domains,protrude |
R78078 |
T66339 |
T85203 |
arg1Of |
incapable,of |
R78096 |
T18180 |
T41564 |
arg2Of |
shielding,of |
R781 |
T775 |
T777 |
arg1Of |
We,undertook |
R78120 |
T4213 |
T33263 |
arg2Of |
evidence,and |
R78128 |
T64543 |
T21071 |
arg2Of |
zoonosis,to |
R78169 |
T73192 |
T19328 |
arg2Of |
result,suggest |
R78175 |
T50969 |
T34676 |
arg2Of |
limit,be |
R782 |
T780 |
T777 |
arg2Of |
analysis,undertook |
R78201 |
T5616 |
T50579 |
arg2Of |
HAs,including |
R78238 |
T67674 |
T40801 |
arg2Of |
comparable,are |
R78256 |
T34663 |
T42643 |
arg2Of |
observed,are |
R783 |
T780 |
T778 |
arg1Of |
analysis,a |
R78301 |
T2354 |
T3040 |
arg1Of |
subunit,S1 |
R78333 |
T23058 |
T22092 |
arg2Of |
Fig. 7,( |
R78342 |
T54865 |
T31567 |
arg3Of |
),( |
R784 |
T780 |
T779 |
arg1Of |
analysis,comparative |
R78404 |
T55295 |
T74940 |
arg1Of |
proteins,"," |
R78452 |
T49843 |
T77547 |
arg1Of |
hotspots,of |
R78471 |
T41188 |
T15094 |
arg3Of |
:,( |
R785 |
T780 |
T781 |
arg1Of |
analysis,of |
R78518 |
T55061 |
T79381 |
arg1Of |
cells,kidney |
R78533 |
T92849 |
T42940 |
arg1Of |
residues,had |
R78557 |
T98636 |
T79458 |
arg1Of |
dN/dS,thus |
R78580 |
T85214 |
T67973 |
arg1Of |
and,11 |
R786 |
T801 |
T781 |
arg2Of |
and,of |
R78609 |
T40164 |
T19897 |
arg1Of |
materials,have |
R78619 |
T64712 |
T33742 |
arg1Of |
bars,The |
R78626 |
T6494 |
T37727 |
arg1Of |
sites,other |
R78632 |
T90485 |
T23317 |
arg1Of |
exemplifies,firmly |
R787 |
T784 |
T782 |
arg1Of |
shields,viral |
R78728 |
T80844 |
T55852 |
arg1Of |
networks,wide-ranging |
R78741 |
T72666 |
T29179 |
arg1Of |
approach,structural |
R788 |
T784 |
T783 |
arg1Of |
shields,glycan |
R78811 |
T11708 |
T15706 |
arg1Of |
5X58,ID |
R78857 |
T76130 |
T2696 |
arg2Of |
site,occluded |
R78874 |
T10175 |
T52708 |
arg2Of |
spectrometry,from |
R789 |
T784 |
T785 |
arg1Of |
shields,from |
R78903 |
T15412 |
T29918 |
arg1Of |
domains,receptor-binding |
R7891 |
T4098 |
T21819 |
arg1Of |
Fig. 6,SI |
R78916 |
T28935 |
T59995 |
arg2Of |
behaviour,in |
R78991 |
T84232 |
T10378 |
arg1Of |
"lectins47,48",recognise |
R79 |
T84 |
T82 |
arg1Of |
density,high |
R790 |
T790 |
T785 |
arg2Of |
proteins,from |
R79004 |
T70221 |
T82660 |
arg1Of |
proteins,( |
R79007 |
T89747 |
T9896 |
arg1Of |
accretion,on |
R79050 |
T46103 |
T44946 |
arg2Of |
MERS,and |
R791 |
T790 |
T786 |
arg2Of |
proteins,characterized |
R79103 |
T93372 |
T10897 |
arg1Of |
accommodate,to |
R7917 |
T84232 |
T90164 |
arg2Of |
"lectins47,48",by |
R79187 |
T46270 |
T95681 |
arg1Of |
models,glycosylated |
R792 |
T790 |
T787 |
arg1Of |
proteins,class |
R79212 |
T17681 |
T12004 |
arg1Of |
candidates,MERS-CoV |
R79222 |
T92120 |
T41703 |
arg1Of |
analysed,then |
R7923 |
T89591 |
T30619 |
arg1Of |
shown,also |
R79248 |
T76353 |
T26368 |
arg1Of |
evolved,since |
R79260 |
T67674 |
T5187 |
arg1Of |
comparable,directly |
R79271 |
T74716 |
T40337 |
arg1Of |
is,surprising |
R79279 |
T12679 |
T68523 |
arg2Of |
CoVs,and |
R793 |
T790 |
T788 |
arg1Of |
proteins,I |
R79333 |
T27628 |
T33888 |
arg3Of |
),( |
R79355 |
T56514 |
T32151 |
arg1Of |
population,arises |
R7938 |
T26472 |
T57713 |
arg1Of |
subunit,the |
R79398 |
T36486 |
T71292 |
arg1Of |
all,of |
R794 |
T790 |
T789 |
arg1Of |
proteins,fusion |
R79407 |
T8708 |
T99300 |
arg1Of |
importance,of |
R79421 |
T73464 |
T48766 |
arg1Of |
library,the |
R79491 |
T70981 |
T34848 |
arg1Of |
due,to |
R795 |
T792 |
T791 |
arg1Of |
highlight,to |
R79506 |
T10901 |
T46398 |
arg2Of |
of,were |
R79509 |
T84653 |
T38543 |
arg2Of |
proteins,glycosylated |
R79558 |
T10907 |
T19441 |
arg1Of |
Hybrid,F |
R796 |
T784 |
T791 |
modOf |
shields,to |
R7964 |
T89667 |
T97762 |
arg2Of |
characterized,was |
R79677 |
T80082 |
T33781 |
arg1Of |
glycopeptides,which |
R797 |
T793 |
T792 |
arg2Of |
how,highlight |
R79721 |
T82634 |
T17084 |
arg2Of |
and,on |
R7973 |
T76361 |
T13147 |
arg1Of |
proteins,S |
R798 |
T796 |
T793 |
arg1Of |
influences,how |
R79815 |
T60225 |
T86262 |
arg1Of |
interactions,host-virus |
R79877 |
T39891 |
T4854 |
arg1Of |
core,the |
R799 |
T795 |
T794 |
arg1Of |
density,glycosylation |
R79922 |
T94055 |
T34101 |
arg1Of |
comparisons,pairwise |
R79979 |
T86129 |
T85155 |
arg1Of |
viruses,able |
R79993 |
T53746 |
T81728 |
arg2Of |
with,compared |
R8 |
T12 |
T10 |
arg1Of |
syndrome,acute |
R80 |
T84 |
T83 |
arg1Of |
density,glycan |
R800 |
T795 |
T796 |
arg1Of |
density,influences |
R80018 |
T81349 |
T82468 |
arg1Of |
glycosylation,viral |
R80062 |
T78881 |
T91114 |
arg1Of |
4O5N,"," |
R80086 |
T5616 |
T5660 |
arg1Of |
HAs,"," |
R80093 |
T14034 |
T48546 |
arg1Of |
processing,i.e. |
R801 |
T799 |
T796 |
arg2Of |
abundance,influences |
R802 |
T799 |
T797 |
arg1Of |
abundance,oligomannose-type |
R80207 |
T9415 |
T12417 |
arg1Of |
variability,the |
R80238 |
T56321 |
T97416 |
arg2Of |
cryo-EM,( |
R803 |
T799 |
T798 |
arg1Of |
abundance,glycan |
R8034 |
T91138 |
T68502 |
arg1Of |
residues,mannose |
R80363 |
T16712 |
T95489 |
arg1Of |
domains,the |
R80364 |
T93681 |
T55814 |
arg2Of |
HAs,and |
R80378 |
T26744 |
T42360 |
arg1Of |
viruses,other |
R8039 |
T47272 |
T70958 |
arg2Of |
fusion,including |
R804 |
T801 |
T800 |
arg1Of |
and,"," |
R80415 |
T33026 |
T15765 |
arg1Of |
glycans,N-linked |
R80462 |
T57392 |
T38584 |
arg1Of |
information,regarding |
R80497 |
T18714 |
T90485 |
arg1Of |
shield,exemplifies |
R805 |
T784 |
T801 |
arg1Of |
shields,and |
R80505 |
T68442 |
T66412 |
arg2Of |
domains,with |
R80519 |
T79677 |
T47791 |
arg1Of |
maps,variability |
R80551 |
T11708 |
T73014 |
arg2Of |
5X58,( |
R80559 |
T40134 |
T10289 |
arg1Of |
degrees,varying |
R806 |
T803 |
T801 |
arg2Of |
relationship,and |
R80635 |
T72666 |
T21412 |
arg1Of |
approach,plotted |
R80658 |
T18790 |
T44481 |
arg2Of |
glycans,by |
R807 |
T803 |
T802 |
arg1Of |
relationship,the |
R80710 |
T13436 |
T55600 |
arg1Of |
but,Indeed |
R80715 |
T19555 |
T95262 |
arg1Of |
importance,in |
R80721 |
T56273 |
T86558 |
arg1Of |
map,of |
R80771 |
T58053 |
T33696 |
arg1Of |
MSV000085152,for |
R808 |
T803 |
T804 |
arg1Of |
relationship,between |
R80868 |
T68699 |
T71503 |
arg2Of |
presented,are |
R80879 |
T60493 |
T54925 |
arg1Of |
using,analyses |
R809 |
T808 |
T804 |
arg2Of |
and,between |
R80940 |
T37894 |
T45576 |
arg1Of |
glycosylated,fully |
R80943 |
T54715 |
T56258 |
arg1Of |
glycans,only |
R80985 |
T30346 |
T31809 |
arg1Of |
sites,these |
R80995 |
T28404 |
T42537 |
arg1Of |
S.,SARS |
R81 |
T80 |
T85 |
arg1Of |
area,on |
R810 |
T807 |
T805 |
arg1Of |
shields,effective |
R81049 |
T32200 |
T51281 |
arg1Of |
antibodies,as |
R81060 |
T46492 |
T25102 |
arg2Of |
and,occluded |
R81081 |
T65172 |
T92413 |
arg2Of |
domain,of |
R811 |
T807 |
T806 |
arg1Of |
shields,glycan |
R81127 |
T55156 |
T13067 |
arg1Of |
vulnerabilities,permeating |
R81139 |
T27945 |
T36773 |
arg2Of |
residues,of |
R81143 |
T24662 |
T56739 |
arg2Of |
GPC,to |
R81181 |
T75003 |
T5230 |
arg1Of |
data,presented |
R81187 |
T16354 |
T90159 |
arg1Of |
models,of |
R81192 |
T6148 |
T3483 |
arg3Of |
using,performed |
R81193 |
T62134 |
T21392 |
arg3Of |
],[ |
R812 |
T807 |
T808 |
arg1Of |
shields,and |
R81263 |
T60433 |
T75361 |
arg2Of |
calculated,was |
R813 |
T811 |
T808 |
arg2Of |
ability,and |
R81334 |
T38368 |
T7627 |
arg1Of |
We,suggest |
R8136 |
T73292 |
T38605 |
arg1Of |
analysis,Site-specific |
R81378 |
T39985 |
T69288 |
arg2Of |
incorporated,can |
R814 |
T811 |
T809 |
arg1Of |
ability,viral |
R815 |
T811 |
T810 |
arg1Of |
ability,evasion |
R8157 |
T35201 |
T83864 |
arg1Of |
reflected,whereas |
R81574 |
T28124 |
T70489 |
arg1Of |
",","," |
R81587 |
T99824 |
T57545 |
arg1Of |
density,the |
R816 |
T816 |
T812 |
arg1Of |
underscore,Together |
R81612 |
T23755 |
T36496 |
arg1Of |
charts,The |
R81614 |
T95787 |
T84433 |
arg1Of |
number,of |
R81667 |
T63465 |
T63209 |
arg1Of |
virus,“evasion |
R81691 |
T56477 |
T73121 |
arg1Of |
is,whereas |
R817 |
T816 |
T813 |
arg1Of |
underscore,"," |
R81741 |
T86087 |
T48007 |
arg2Of |
mutations,of |
R818 |
T815 |
T814 |
arg1Of |
data,these |
R81839 |
T88004 |
T43617 |
arg1Of |
mutants,glycan-KO |
R81851 |
T74546 |
T11993 |
arg1Of |
investigated,also |
R81871 |
T15004 |
T27520 |
arg2Of |
region,in |
R81880 |
T31925 |
T4958 |
arg1Of |
",",respectively |
R81896 |
T65172 |
T48963 |
arg1Of |
domain,the |
R819 |
T815 |
T816 |
arg1Of |
data,underscore |
R81910 |
T34685 |
T91376 |
arg1Of |
and,larger |
R8195 |
T3893 |
T1991 |
arg2Of |
shown,"," |
R81995 |
T36825 |
T5712 |
arg3Of |
),( |
R82 |
T87 |
T85 |
arg2Of |
S,on |
R820 |
T818 |
T816 |
arg2Of |
importance,underscore |
R82082 |
T18688 |
T54076 |
arg1Of |
SARS,and |
R82084 |
T28675 |
T51290 |
arg2Of |
sensitive,are |
R82099 |
T67026 |
T21547 |
arg1Of |
domains,the |
R821 |
T818 |
T817 |
arg1Of |
importance,the |
R82101 |
T20315 |
T28124 |
arg1Of |
",","," |
R82156 |
T26744 |
T82055 |
arg1Of |
viruses,as |
R82172 |
T75679 |
T96992 |
arg1Of |
sequences,MERS |
R822 |
T818 |
T819 |
arg1Of |
importance,of |
R82201 |
T1830 |
T83757 |
arg1Of |
hinders,"," |
R8222 |
T3483 |
T62380 |
arg1Of |
performed,"," |
R82223 |
T60202 |
T35932 |
arg1Of |
Fig.,6 |
R82225 |
T94995 |
T43286 |
arg2Of |
it,penetrate |
R82299 |
T59290 |
T1830 |
arg1Of |
and,hinders |
R823 |
T820 |
T819 |
arg2Of |
glycosylation,of |
R82360 |
T43073 |
T91266 |
arg1Of |
overlaid,map |
R824 |
T818 |
T821 |
arg1Of |
importance,in |
R82405 |
T49535 |
T90485 |
arg2Of |
it,exemplifies |
R82423 |
T72666 |
T54019 |
arg1Of |
approach,a |
R82455 |
T72864 |
T60407 |
arg1Of |
S1,and |
R82494 |
T88882 |
T33407 |
arg1Of |
subject,likely |
R825 |
T824 |
T821 |
arg2Of |
evasion,in |
R8253 |
T16085 |
T80700 |
arg1Of |
resolutions,the |
R8259 |
T56838 |
T86817 |
arg2Of |
protease,"," |
R826 |
T824 |
T822 |
arg1Of |
evasion,viral |
R82627 |
T14376 |
T27441 |
arg1Of |
J.S.M.,is |
R827 |
T824 |
T823 |
arg1Of |
evasion,immune |
R82759 |
T12473 |
T49752 |
arg1Of |
reduced,( |
R82764 |
T22349 |
T84588 |
arg2Of |
viruses,to |
R82776 |
T96423 |
T16192 |
arg1Of |
spikes,using |
R828 |
T825 |
T826 |
arg1Of |
Results,and |
R82819 |
T43073 |
T51416 |
arg1Of |
overlaid,a |
R82820 |
T99241 |
T52952 |
arg2Of |
with,compared |
R82833 |
T78120 |
T15044 |
arg2Of |
2D-variability,and |
R82865 |
T98975 |
T16688 |
arg2Of |
majority,for |
R82869 |
T54925 |
T13544 |
arg1Of |
analyses,of |
R829 |
T827 |
T826 |
arg2Of |
discussion,and |
R8290 |
T10460 |
T78780 |
arg1Of |
and,MERS |
R82991 |
T77800 |
T64664 |
arg1Of |
analysis,revealed |
R83 |
T87 |
T86 |
arg1Of |
S,MERS |
R830 |
T829 |
T828 |
arg1Of |
processing,Glycan |
R8307 |
T80639 |
T14256 |
arg2Of |
diversity,with |
R83070 |
T12246 |
T16571 |
arg1Of |
sites,glycosylation |
R831 |
T829 |
T830 |
arg1Of |
processing,of |
R83158 |
T31427 |
T76296 |
arg1Of |
proteins,were |
R83184 |
T29760 |
T29294 |
arg2Of |
repeat,"," |
R832 |
T833 |
T830 |
arg2Of |
and,of |
R83234 |
T2995 |
T66016 |
arg2Of |
study,of |
R83267 |
T16354 |
T84875 |
arg3Of |
models,generated |
R83297 |
T10009 |
T95182 |
arg2Of |
studied,"," |
R833 |
T832 |
T831 |
arg1Of |
SARS,trimeric |
R83314 |
T54715 |
T89329 |
arg2Of |
glycans,isolated |
R8332 |
T30217 |
T24446 |
arg1Of |
modelling,of |
R83333 |
T67674 |
T16791 |
arg1Of |
comparable,between |
R8334 |
T99279 |
T92949 |
arg1Of |
J.S.M.,and |
R83350 |
T38232 |
T41652 |
arg2Of |
traces,as |
R83368 |
T82356 |
T87134 |
arg1Of |
diversity,in |
R834 |
T832 |
T833 |
arg1Of |
SARS,and |
R83407 |
T11968 |
T7451 |
arg2Of |
Interfaces,"," |
R83415 |
T95298 |
T56194 |
arg2Of |
copies,with |
R83418 |
T70221 |
T91777 |
arg1Of |
proteins,HKU1 |
R83430 |
T16169 |
T7534 |
arg2Of |
interpretability,limits |
R83497 |
T97319 |
T54253 |
arg1Of |
role,major |
R835 |
T836 |
T833 |
arg2Of |
proteins,and |
R83504 |
T32200 |
T53019 |
arg2Of |
antibodies,by |
R83516 |
T77334 |
T3264 |
arg1Of |
We,investigated |
R83519 |
T66745 |
T96535 |
arg2Of |
trimer,throughout |
R83562 |
T14383 |
T56235 |
arg1Of |
Env,HIV-1 |
R836 |
T836 |
T834 |
arg1Of |
proteins,MERS |
R83664 |
T52822 |
T32196 |
arg3Of |
visualize,In |
R83690 |
T1661 |
T98847 |
arg1Of |
glycans,these |
R837 |
T836 |
T835 |
arg1Of |
proteins,spike |
R8373 |
T14068 |
T36252 |
arg1Of |
exposed,and |
R83742 |
T45372 |
T9612 |
arg1Of |
tempting,"," |
R838 |
T838 |
T837 |
arg1Of |
generate,To |
R83861 |
T99799 |
T3017 |
arg1Of |
glycoproteins,11 |
R839 |
T849 |
T837 |
modOf |
used,To |
R83994 |
T30415 |
T52236 |
arg1Of |
compare,with |
R83995 |
T54061 |
T48581 |
arg1Of |
proteins,b |
R84 |
T80 |
T88 |
arg1Of |
area,that |
R840 |
T848 |
T838 |
arg1Of |
we,generate |
R84025 |
T82430 |
T89162 |
arg1Of |
combination,as |
R84039 |
T75213 |
T43420 |
arg1Of |
peptide,and |
R8406 |
T35287 |
T35247 |
arg1Of |
virus,simian |
R841 |
T841 |
T838 |
arg2Of |
mimic,generate |
R84135 |
T68027 |
T88612 |
arg1Of |
level,a |
R84142 |
T4934 |
T87263 |
arg2Of |
responses,by |
R842 |
T841 |
T839 |
arg1Of |
mimic,a |
R84232 |
T34718 |
T34663 |
arg3Of |
As,observed |
R84233 |
T43199 |
T13552 |
arg1Of |
diversity,genetic |
R8424 |
T15422 |
T85581 |
arg2Of |
surface,over |
R8425 |
T47125 |
T63067 |
arg1Of |
results,were |
R843 |
T841 |
T840 |
arg1Of |
mimic,soluble |
R84300 |
T99472 |
T76117 |
arg2Of |
constraints,to |
R84349 |
T5930 |
T8049 |
arg1Of |
infectivity,and |
R84393 |
T93319 |
T26621 |
arg1Of |
domains,central |
R844 |
T841 |
T842 |
arg1Of |
mimic,of |
R84419 |
T47125 |
T36239 |
arg1Of |
results,for |
R845 |
T846 |
T842 |
arg2Of |
proteins,of |
R84573 |
T63130 |
T65568 |
arg1Of |
surface,protein |
R84584 |
T44450 |
T90266 |
arg1Of |
coronaviruses,SARS |
R846 |
T846 |
T843 |
arg1Of |
proteins,the |
R84605 |
T66804 |
T66208 |
arg2Of |
surface,between |
R84616 |
T64768 |
T68800 |
arg1Of |
represent,"," |
R84660 |
T62826 |
T41174 |
arg1Of |
Fig. 2a,"," |
R84665 |
T28528 |
T60922 |
arg1Of |
measure,for |
R84672 |
T26990 |
T48789 |
arg2Of |
A,in |
R84689 |
T71248 |
T26853 |
arg2Of |
expressed,were |
R847 |
T846 |
T844 |
arg1Of |
proteins,viral |
R84719 |
T53941 |
T55209 |
arg1Of |
SOSIP.664,BG505 |
R84767 |
T4934 |
T84547 |
arg1Of |
responses,host |
R84776 |
T38543 |
T78070 |
arg1Of |
glycosylated,to |
R84782 |
T93319 |
T88882 |
arg1Of |
domains,subject |
R84789 |
T37597 |
T46398 |
arg1Of |
data,were |
R848 |
T846 |
T845 |
arg1Of |
proteins,S |
R84867 |
T1436 |
T1435 |
arg1Of |
regions,accessible |
R849 |
T849 |
T847 |
arg1Of |
used,"," |
R84962 |
T79747 |
T86418 |
arg1Of |
key,defined |
R84986 |
T91715 |
T8442 |
arg2Of |
glycoproteins,on |
R85 |
T80 |
T89 |
arg1Of |
area,results |
R850 |
T848 |
T849 |
arg1Of |
we,used |
R8502 |
T61005 |
T70489 |
arg2Of |
Env,"," |
R85023 |
T20998 |
T90752 |
arg1Of |
regions,oligomannose |
R85024 |
T31963 |
T11453 |
arg1Of |
interact,with |
R85033 |
T73114 |
T73791 |
arg1Of |
compare,to |
R85039 |
T47078 |
T36523 |
arg1Of |
possesses,with |
R85045 |
T79412 |
T18710 |
arg1Of |
is,"," |
R85062 |
T73464 |
T54010 |
arg2Of |
library,on |
R85070 |
T20304 |
T1345 |
arg1Of |
differences,( |
R85086 |
T14383 |
T33263 |
arg1Of |
Env,and |
R851 |
T854 |
T849 |
arg2Of |
and,used |
R85112 |
T10045 |
T37112 |
arg1Of |
known,also |
R85123 |
T55061 |
T85286 |
arg2Of |
cells,from |
R85159 |
T70541 |
T87732 |
arg2Of |
and,can |
R852 |
T853 |
T850 |
arg1Of |
SARS,the |
R85204 |
T83032 |
T5512 |
arg1Of |
is,"," |
R85216 |
T70602 |
T67118 |
arg1Of |
Assemblies,( |
R8522 |
T94502 |
T64033 |
arg2Of |
Fig. 5,( |
R85221 |
T20594 |
T55109 |
arg1Of |
residues,solvent-accessible |
R85227 |
T93591 |
T39186 |
arg2Of |
elevated,found |
R85283 |
T7777 |
T23472 |
arg1Of |
regions,in |
R853 |
T853 |
T851 |
arg1Of |
SARS,2P-stabilised |
R85307 |
T33538 |
T1666 |
arg1Of |
glycosylation,coronavirus |
R85323 |
T5319 |
T34520 |
arg3Of |
),( |
R85326 |
T98112 |
T74716 |
arg1Of |
domain,is |
R85329 |
T68396 |
T92120 |
arg1Of |
MS,analysed |
R85368 |
T65616 |
T83825 |
arg1Of |
circles,indicate |
R85372 |
T63927 |
T40801 |
arg1Of |
they,are |
R85394 |
T99530 |
T60926 |
arg2Of |
analysis,were |
R85398 |
T70323 |
T14482 |
arg1Of |
proteins,respective |
R854 |
T853 |
T852 |
arg1Of |
SARS,native-like |
R85433 |
T30294 |
T11420 |
arg1Of |
densities,shield |
R85434 |
T93687 |
T31999 |
arg1Of |
",",and |
R8545 |
T89747 |
T86415 |
arg1Of |
accretion,of |
R85450 |
T97622 |
T28690 |
arg2Of |
comparisons,disallow |
R85455 |
T99799 |
T4404 |
arg2Of |
glycoproteins,and |
R85461 |
T53941 |
T81241 |
arg1Of |
SOSIP.664,for |
R855 |
T853 |
T854 |
arg1Of |
SARS,and |
R85546 |
T68640 |
T24930 |
arg1Of |
proteins,S |
R85552 |
T84155 |
T77249 |
arg1Of |
functions,"," |
R85556 |
T19959 |
T53841 |
arg2Of |
remaining,while |
R8557 |
T39941 |
T78537 |
arg2Of |
genes,of |
R85584 |
T73691 |
T75651 |
arg2Of |
and,of |
R8559 |
T85741 |
T14842 |
arg2Of |
map,of |
R856 |
T858 |
T854 |
arg2Of |
antigens,and |
R85642 |
T83864 |
T58557 |
arg1Of |
whereas,"," |
R85655 |
T25121 |
T22092 |
arg1Of |
deletions,( |
R85691 |
T3445 |
T26714 |
arg2Of |
glycosylation,of |
R857 |
T858 |
T855 |
arg1Of |
antigens,MERS |
R85720 |
T98112 |
T56881 |
arg1Of |
domain,receptor-binding |
R858 |
T858 |
T856 |
arg1Of |
antigens,S |
R85815 |
T80844 |
T83936 |
arg1Of |
networks,that |
R85823 |
T69932 |
T90504 |
arg2Of |
define,serve |
R85836 |
T12203 |
T37340 |
arg2Of |
spike,targeting |
R859 |
T858 |
T857 |
arg1Of |
antigens,protein |
R85917 |
T12679 |
T70297 |
arg1Of |
CoVs,MERS |
R85973 |
T90304 |
T58601 |
arg2Of |
Fig. 8,( |
R86 |
T89 |
T90 |
arg1Of |
results,in |
R860 |
T868 |
T859 |
arg1Of |
described,"," |
R86027 |
T15871 |
T69209 |
arg1Of |
March,17 |
R8603 |
T77964 |
T99997 |
arg2Of |
understanding,to |
R86035 |
T64538 |
T35201 |
arg2Of |
notion,reflected |
R8606 |
T5495 |
T50640 |
arg2Of |
mutations,and |
R861 |
T862 |
T860 |
arg1Of |
and,the |
R86107 |
T32530 |
T45598 |
arg1Of |
are,also |
R86109 |
T53941 |
T54597 |
arg1Of |
SOSIP.664,but |
R86127 |
T40801 |
T88580 |
arg1Of |
are,) |
R86135 |
T46492 |
T30435 |
arg2Of |
and,targeted |
R86146 |
T51449 |
T69255 |
arg1Of |
proteins,viral |
R86174 |
T31427 |
T43119 |
arg1Of |
proteins,SARS |
R862 |
T861 |
T862 |
arg1Of |
design,and |
R86243 |
T49843 |
T5765 |
arg1Of |
hotspots,were |
R863 |
T863 |
T862 |
arg2Of |
structures,and |
R86331 |
T28685 |
T85420 |
arg1Of |
proteins,fusion |
R86375 |
T35196 |
T48789 |
arg1Of |
shown,in |
R864 |
T862 |
T864 |
arg1Of |
and,of |
R8642 |
T92271 |
T76290 |
arg1Of |
rate66,mutation |
R86433 |
T16112 |
T86019 |
arg1Of |
diversification,Fig. |
R86434 |
T57322 |
T64664 |
arg2Of |
and,revealed |
R86473 |
T20304 |
T58234 |
arg1Of |
differences,multiple |
R86475 |
T68027 |
T55069 |
arg1Of |
level,low |
R865 |
T858 |
T864 |
arg2Of |
antigens,of |
R866 |
T858 |
T865 |
arg1Of |
antigens,which |
R86604 |
T39562 |
T17578 |
arg1Of |
b,3D |
R86649 |
T54943 |
T82922 |
arg2Of |
coronavirus,on |
R86686 |
T71776 |
T7784 |
arg1Of |
interactions,that |
R867 |
T862 |
T866 |
arg1Of |
and,have |
R868 |
T868 |
T866 |
arg2Of |
described,have |
R86812 |
T73688 |
T36751 |
arg1Of |
effects,glycan |
R86836 |
T75679 |
T87940 |
arg2Of |
sequences,and |
R86859 |
T82693 |
T17765 |
arg1Of |
and,"," |
R86884 |
T75718 |
T49217 |
arg1Of |
mapping,3 |
R86898 |
T82356 |
T4452 |
arg1Of |
diversity,a |
R869 |
T862 |
T867 |
arg1Of |
and,been |
R86915 |
T13983 |
T78740 |
arg1Of |
arise,that |
R87 |
T92 |
T90 |
arg2Of |
formation,in |
R870 |
T868 |
T867 |
arg2Of |
described,been |
R87012 |
T82084 |
T26521 |
arg2Of |
S,on |
R87062 |
T18623 |
T56324 |
arg1Of |
processed,most |
R87066 |
T30265 |
T57197 |
arg1Of |
reproduced,directly |
R871 |
T873 |
T868 |
arg1Of |
al.41,described |
R87124 |
T15871 |
T93347 |
arg2Of |
March,of |
R8717 |
T58379 |
T16051 |
arg1Of |
target,main |
R87187 |
T84155 |
T82847 |
arg2Of |
functions,performing |
R872 |
T862 |
T868 |
arg2Of |
and,described |
R87205 |
T31709 |
T33845 |
arg2Of |
structure,hidden |
R87208 |
T64136 |
T33083 |
arg2Of |
dashed,( |
R8726 |
T11216 |
T96660 |
arg2Of |
reduced,and |
R87260 |
T49812 |
T85286 |
arg1Of |
particles,from |
R87289 |
T76130 |
T72556 |
arg1Of |
site,of |
R87294 |
T84080 |
T57322 |
arg2Of |
changes,and |
R873 |
T868 |
T869 |
arg1Of |
described,previously |
R874 |
T873 |
T870 |
arg2Of |
al.41,by |
R87433 |
T39300 |
T68800 |
arg2Of |
afucosylated,"," |
R87495 |
T89403 |
T32196 |
arg1Of |
used,In |
R875 |
T872 |
T871 |
arg1Of |
et,Pallesen |
R87502 |
T83803 |
T28189 |
arg1Of |
M9,; |
R87543 |
T99864 |
T9349 |
arg1Of |
5X59,ID |
R87571 |
T27441 |
T17945 |
arg1Of |
is,no |
R876 |
T873 |
T872 |
arg1Of |
al.41,et |
R87623 |
T3264 |
T62822 |
arg1Of |
investigated,then |
R87652 |
T64040 |
T17730 |
arg2Of |
and,across |
R87676 |
T7969 |
T86415 |
arg2Of |
glycans,of |
R877 |
T874 |
T875 |
arg1Of |
SARS,"," |
R87747 |
T28675 |
T51626 |
arg1Of |
sensitive,to |
R87779 |
T35349 |
T29813 |
arg1Of |
subunits,are |
R878 |
T876 |
T875 |
arg2Of |
MERS,"," |
R87857 |
T15804 |
T52826 |
arg1Of |
elicit,upon |
R87860 |
T15044 |
T29355 |
arg2Of |
and,to |
R87862 |
T51881 |
T26477 |
arg2Of |
least,Left |
R879 |
T875 |
T877 |
arg1Of |
",",and |
R87982 |
T92063 |
T24408 |
arg1Of |
glycans,N-linked |
R87987 |
T37597 |
T74879 |
arg1Of |
data,SARS |
R87991 |
T19328 |
T15548 |
arg2Of |
suggest,would |
R88 |
T92 |
T91 |
arg1Of |
formation,the |
R880 |
T880 |
T877 |
arg2Of |
genes,and |
R88002 |
T3180 |
T62295 |
arg1Of |
analysis,of |
R88051 |
T68681 |
T20175 |
arg1Of |
knock,out |
R881 |
T880 |
T878 |
arg1Of |
genes,HKU1 |
R88101 |
T24662 |
T26633 |
arg1Of |
GPC,the |
R88109 |
T12587 |
T55529 |
arg2Of |
environment,in |
R88141 |
T75209 |
T37067 |
arg2Of |
ectodomain52,visualized |
R882 |
T880 |
T879 |
arg1Of |
genes,S |
R88211 |
T13208 |
T66915 |
arg1Of |
",",and |
R883 |
T877 |
T881 |
arg1Of |
and,encode |
R88310 |
T52275 |
T53697 |
arg1Of |
reveal,in |
R8832 |
T91376 |
T14852 |
arg1Of |
larger,significantly |
R88347 |
T16712 |
T80363 |
arg1Of |
domains,receptor-binding |
R8839 |
T11220 |
T12255 |
arg1Of |
dynamics,glycan |
R88392 |
T30580 |
T18378 |
arg3Of |
),( |
R88399 |
T67621 |
T29228 |
arg2Of |
hand,on |
R884 |
T886 |
T881 |
arg2Of |
;,encode |
R88458 |
T3262 |
T11057 |
arg1Of |
glycoproteins,analysis |
R885 |
T885 |
T882 |
arg1Of |
sequons,many |
R88573 |
T92287 |
T83087 |
arg2Of |
exhibited,revealed |
R886 |
T885 |
T883 |
arg1Of |
sequons,N-linked |
R88638 |
T24985 |
T96776 |
arg2Of |
that,of |
R887 |
T885 |
T884 |
arg1Of |
sequons,glycan |
R88738 |
T13118 |
T53309 |
arg1Of |
synonymous,non-synonymous |
R88756 |
T66804 |
T69932 |
arg1Of |
surface,define |
R88765 |
T39891 |
T26493 |
arg2Of |
core,from |
R888 |
T885 |
T886 |
arg1Of |
sequons,; |
R88806 |
T3893 |
T21495 |
arg2Of |
shown,were |
R88808 |
T2410 |
T8985 |
arg1Of |
sites,the |
R88814 |
T13983 |
T11037 |
arg2Of |
arise,speculate |
R88830 |
T66936 |
T73735 |
arg1Of |
number,was |
R88839 |
T1670 |
T34347 |
arg1Of |
trimming,"," |
R88856 |
T65162 |
T41593 |
arg1Of |
titres,of |
R889 |
T890 |
T886 |
arg2Of |
and,; |
R88912 |
T26227 |
T23601 |
arg1Of |
abundance,the |
R88932 |
T52131 |
T92018 |
arg2Of |
N-glycans,released |
R88937 |
T99824 |
T1558 |
arg1Of |
density,glycan |
R88967 |
T48593 |
T79082 |
arg1Of |
interactions,extensive |
R88973 |
T33012 |
T69427 |
arg2Of |
Victoria,( |
R89 |
T92 |
T93 |
arg1Of |
formation,of |
R890 |
T887 |
T888 |
arg1Of |
23,"," |
R89049 |
T60437 |
T28667 |
arg1Of |
total,of |
R89054 |
T38777 |
T90908 |
arg1Of |
densities,the |
R89068 |
T20998 |
T77065 |
arg1Of |
regions,the |
R89069 |
T73605 |
T65049 |
arg2Of |
flexibility,maintaining |
R8907 |
T81413 |
T68523 |
arg1Of |
SARS,and |
R891 |
T889 |
T888 |
arg2Of |
23,"," |
R89109 |
T46398 |
T17171 |
arg1Of |
were,"," |
R89120 |
T2587 |
T7289 |
arg2Of |
https,( |
R892 |
T888 |
T890 |
arg1Of |
",",and |
R89282 |
T56245 |
T88998 |
arg2Of |
antibodies,as |
R893 |
T891 |
T890 |
arg2Of |
29,and |
R8931 |
T74143 |
T4164 |
arg1Of |
density,may |
R89372 |
T8652 |
T27352 |
arg1Of |
digested,with |
R894 |
T886 |
T892 |
arg1Of |
;,"," |
R89430 |
T75686 |
T84570 |
arg1Of |
proteins,SARS |
R89466 |
T67026 |
T68704 |
arg1Of |
domains,exist |
R895 |
T886 |
T893 |
arg1Of |
;,respectively |
R89512 |
T43620 |
T92642 |
arg3Of |
),( |
R89552 |
T29672 |
T9596 |
arg1Of |
datasets,of |
R896 |
T886 |
T894 |
arg1Of |
;,( |
R89667 |
T69025 |
T69927 |
arg1Of |
analysis,glycopeptides |
R897 |
T895 |
T894 |
arg2Of |
Fig. 1a,( |
R898 |
T896 |
T894 |
arg3Of |
),( |
R89891 |
T11216 |
T27277 |
arg1Of |
reduced,in |
R899 |
T899 |
T898 |
arg1Of |
sought,initially |
R89913 |
T91715 |
T27531 |
arg1Of |
glycoproteins,other |
R89979 |
T35120 |
T20638 |
arg2Of |
subjected,were |
R8999 |
T72680 |
T77073 |
arg1Of |
linked,Whether |
R9 |
T12 |
T11 |
arg1Of |
syndrome,respiratory |
R90 |
T96 |
T93 |
arg2Of |
clusters,of |
R900 |
T897 |
T899 |
arg1Of |
We,sought |
R90004 |
T95298 |
T46276 |
arg1Of |
copies,three |
R90040 |
T52825 |
T13519 |
arg1Of |
glycans,these |
R90057 |
T3893 |
T10706 |
arg1Of |
shown,however |
R90066 |
T34122 |
T47078 |
arg1Of |
SARS-CoV-2,possesses |
R90068 |
T75525 |
T91248 |
arg1Of |
“shield”,glycan |
R90078 |
T1566 |
T10659 |
arg2Of |
opposed,as |
R901 |
T902 |
T899 |
arg2Of |
assess,sought |
R90105 |
T40780 |
T42499 |
arg1Of |
clusters,on |
R90148 |
T63261 |
T5337 |
arg1Of |
leads,that |
R90166 |
T2961 |
T30445 |
arg1Of |
had,compared |
R90176 |
T45573 |
T3633 |
arg3Of |
),( |
R90190 |
T41193 |
T54555 |
arg1Of |
compositions,at |
R902 |
T902 |
T900 |
arg1Of |
assess,to |
R90220 |
T75525 |
T73077 |
arg1Of |
“shield”,the |
R90259 |
T42487 |
T3483 |
arg2Of |
evaluation,performed |
R903 |
T902 |
T901 |
arg1Of |
assess,quantitatively |
R90310 |
T39713 |
T72942 |
arg1Of |
they,can |
R90371 |
T10448 |
T68645 |
arg1Of |
are,"," |
R90378 |
T32345 |
T22228 |
arg1Of |
environment,host |
R904 |
T897 |
T902 |
arg1Of |
We,assess |
R90435 |
T65868 |
T23843 |
arg1Of |
terms,of |
R905 |
T904 |
T902 |
arg2Of |
composition,assess |
R9050 |
T71022 |
T87387 |
arg1Of |
S,and |
R90505 |
T75679 |
T21364 |
arg1Of |
sequences,gene |
R90521 |
T84653 |
T49065 |
arg1Of |
proteins,envelope |
R90522 |
T92910 |
T71146 |
arg2Of |
Residues,colored |
R90546 |
T16113 |
T79466 |
arg1Of |
panel,Left |
R90565 |
T37933 |
T36054 |
arg1Of |
and,which |
R90591 |
T31010 |
T95071 |
arg2Of |
correlation,observed |
R906 |
T904 |
T903 |
arg1Of |
composition,the |
R90671 |
T37762 |
T60903 |
arg1Of |
additions,site |
R907 |
T904 |
T905 |
arg1Of |
composition,of |
R90709 |
T64543 |
T25999 |
arg1Of |
zoonosis,the |
R90758 |
T57392 |
T29532 |
arg1Of |
information,can |
R90788 |
T94871 |
T71413 |
arg1Of |
shield,of |
R908 |
T907 |
T905 |
arg2Of |
carbohydrate,of |
R90800 |
T41923 |
T4404 |
arg1Of |
11,and |
R90824 |
T71146 |
T69312 |
arg1Of |
colored,and |
R90854 |
T19388 |
T37715 |
arg1Of |
al.51,et |
R90881 |
T86576 |
T2448 |
arg3Of |
),( |
R909 |
T907 |
T906 |
arg1Of |
carbohydrate,the |
R90965 |
T31709 |
T9264 |
arg2Of |
structure,reveal |
R91 |
T96 |
T94 |
arg1Of |
clusters,oligomannose-type |
R910 |
T908 |
T909 |
arg1Of |
structures,displayed |
R9103 |
T65772 |
T84841 |
arg1Of |
abundance,oligomannose |
R91092 |
T59844 |
T49747 |
arg2Of |
to,according |
R911 |
T904 |
T909 |
arg2Of |
composition,displayed |
R91100 |
T46492 |
T46892 |
arg1Of |
and,are |
R91132 |
T68778 |
T46258 |
arg1Of |
it,would |
R91159 |
T9382 |
T51534 |
arg1Of |
S,MERS |
R91171 |
T80516 |
T24089 |
arg1Of |
aid,to |
R912 |
T909 |
T910 |
arg1Of |
displayed,on |
R91207 |
T14194 |
T4820 |
arg1Of |
glycosylation,observed |
R91245 |
T39503 |
T1176 |
arg1Of |
this,may |
R91250 |
T76651 |
T27352 |
arg2Of |
assortment,with |
R913 |
T913 |
T910 |
arg2Of |
glycoproteins,on |
R91304 |
T24146 |
T7451 |
arg1Of |
Proteins,"," |
R91364 |
T5164 |
T67945 |
arg1Of |
modelling,is |
R914 |
T913 |
T911 |
arg1Of |
glycoproteins,the |
R91411 |
T48779 |
T11920 |
arg1Of |
indicated,"," |
R91435 |
T64790 |
T55283 |
arg1Of |
We,showed51 |
R915 |
T913 |
T912 |
arg1Of |
glycoproteins,S |
R91526 |
T41175 |
T50624 |
arg1Of |
strong”56,“evasion |
R91530 |
T88079 |
T71010 |
arg1Of |
5X58,PDB |
R91538 |
T79412 |
T82304 |
arg1Of |
is,However |
R91541 |
T10413 |
T32469 |
arg2Of |
and,of |
R91588 |
T50771 |
T66305 |
arg1Of |
it,is |
R916 |
T915 |
T914 |
arg2Of |
glycans,N-linked |
R91605 |
T65168 |
T64192 |
arg1Of |
content,oligomannose |
R91639 |
T41193 |
T88928 |
arg1Of |
compositions,of |
R91640 |
T84269 |
T82701 |
arg1Of |
efficacies,shielding |
R91669 |
T65417 |
T63529 |
arg1Of |
differ,"," |
R917 |
T915 |
T916 |
arg1Of |
glycans,were |
R91717 |
T49009 |
T70456 |
arg1Of |
structure,This |
R91721 |
T76130 |
T66548 |
arg1Of |
site,DPP4 |
R91746 |
T16458 |
T55752 |
arg1Of |
dataset52,the |
R9175 |
T47420 |
T12510 |
arg1Of |
number,the |
R91771 |
T68027 |
T38898 |
arg1Of |
level,contour |
R91789 |
T46654 |
T52603 |
arg1Of |
data,accompanying |
R918 |
T919 |
T916 |
arg2Of |
",",were |
R91807 |
T95182 |
T62794 |
arg1Of |
",",demonstrate |
R91821 |
T42577 |
T95262 |
arg2Of |
modulation,in |
R91856 |
T93400 |
T18456 |
arg1Of |
N-linked,Fig. |
R91860 |
T68738 |
T29834 |
arg1Of |
comparable,within |
R91871 |
T21302 |
T87387 |
arg2Of |
shields,and |
R91880 |
T13067 |
T40910 |
arg1Of |
permeating,through |
R919 |
T919 |
T917 |
arg1Of |
",",enzymatically |
R9199 |
T53051 |
T61501 |
arg2Of |
Env,"," |
R92 |
T96 |
T95 |
arg1Of |
clusters,glycan |
R920 |
T915 |
T918 |
arg2Of |
glycans,released |
R92098 |
T89662 |
T88210 |
arg1Of |
S,SARS |
R921 |
T918 |
T919 |
arg1Of |
released,"," |
R92116 |
T49864 |
T28659 |
arg1Of |
glycans,hybrid |
R92134 |
T75718 |
T97068 |
arg1Of |
mapping,of |
R92159 |
T27860 |
T47196 |
arg2Of |
events,by |
R92165 |
T99953 |
T34488 |
arg3Of |
),( |
R92167 |
T47096 |
T17293 |
arg2Of |
b,and |
R92191 |
T40164 |
T54231 |
arg1Of |
materials,been |
R92196 |
T19555 |
T59672 |
arg2Of |
importance,considered |
R922 |
T923 |
T919 |
arg2Of |
and,"," |
R9225 |
T5302 |
T90081 |
arg2Of |
clusters,exhibit |
R923 |
T923 |
T920 |
arg1Of |
and,fluorescently |
R92325 |
T40508 |
T59664 |
arg1Of |
sites,DPP4 |
R9235 |
T94571 |
T97123 |
arg2Of |
"procainamide24,45,53",with |
R92379 |
T92063 |
T21392 |
arg1Of |
glycans,[ |
R92380 |
T56273 |
T6423 |
arg1Of |
map,C3-symmetric |
R924 |
T915 |
T921 |
arg2Of |
glycans,labelled |
R92418 |
T41193 |
T52563 |
arg1Of |
compositions,the |
R92469 |
T43199 |
T65839 |
arg1Of |
diversity,and |
R925 |
T923 |
T922 |
arg1Of |
and,"," |
R92510 |
T29095 |
T96495 |
arg2Of |
group,of |
R92515 |
T24905 |
T80023 |
arg2Of |
area,"," |
R92524 |
T93138 |
T86575 |
arg1Of |
digested,with |
R92527 |
T65176 |
T50763 |
arg2Of |
n = 566,( |
R92531 |
T25884 |
T75654 |
arg1Of |
values,for |
R92599 |
T67026 |
T24397 |
arg1Of |
domains,receptor-binding |
R926 |
T921 |
T923 |
arg1Of |
labelled,and |
R92684 |
T49127 |
T15094 |
arg2Of |
ID,( |
R927 |
T924 |
T923 |
arg2Of |
subjected,and |
R92714 |
T15004 |
T14842 |
arg1Of |
region,of |
R92729 |
T29095 |
T19945 |
arg1Of |
group,each |
R92766 |
T1661 |
T90570 |
arg2Of |
glycans,of |
R928 |
T915 |
T924 |
arg2Of |
glycans,subjected |
R92800 |
T86925 |
T66610 |
arg1Of |
series,oligomannose-type |
R9284 |
T96751 |
T97449 |
arg3Of |
),( |
R929 |
T924 |
T925 |
arg1Of |
subjected,to |
R92973 |
T18965 |
T82634 |
arg1Of |
proteins,and |
R92976 |
T7550 |
T53210 |
arg1Of |
accumulation,the |
R93 |
T96 |
T97 |
arg1Of |
clusters,"," |
R930 |
T930 |
T925 |
arg2Of |
chromatography,to |
R93010 |
T89747 |
T82950 |
arg1Of |
accretion,the |
R93032 |
T52825 |
T42882 |
arg2Of |
glycans,underprocessed |
R93062 |
T55814 |
T25906 |
arg2Of |
and,where |
R93094 |
T13118 |
T78726 |
arg1Of |
synonymous,to |
R931 |
T930 |
T926 |
arg1Of |
chromatography,hydrophilic |
R93131 |
T90188 |
T57750 |
arg1Of |
map,of |
R93165 |
T80263 |
T56636 |
arg1Of |
development,the |
R932 |
T930 |
T927 |
arg1Of |
chromatography,interaction |
R93264 |
T92271 |
T95094 |
arg1Of |
rate66,high |
R93289 |
T84994 |
T23943 |
arg1Of |
processing,the |
R933 |
T930 |
T928 |
arg1Of |
chromatography,chromatography-ultra-performance |
R93381 |
T48265 |
T94495 |
arg1Of |
quantities,relative |
R934 |
T930 |
T929 |
arg1Of |
chromatography,liquid |
R93413 |
T40498 |
T97839 |
arg2Of |
lack,note |
R93473 |
T21025 |
T36644 |
arg2Of |
abundances,ascertained |
R935 |
T930 |
T931 |
arg1Of |
chromatography,( |
R93509 |
T81297 |
T32584 |
arg1Of |
surface,protein |
R93551 |
T10324 |
T58404 |
arg1Of |
ratios,i.e. |
R93589 |
T82683 |
T24919 |
arg1Of |
deposited,on |
R936 |
T932 |
T931 |
arg2Of |
HILIC-UPLC,( |
R9362 |
T61553 |
T17900 |
arg1Of |
trypsin,plus |
R93623 |
T13186 |
T78182 |
arg2Of |
coronaviruses,of |
R93652 |
T93319 |
T34460 |
arg1Of |
domains,the |
R9367 |
T86793 |
T61088 |
arg2Of |
epitopes,targeted |
R937 |
T933 |
T931 |
arg3Of |
),( |
R93793 |
T50573 |
T85872 |
arg1Of |
and,"," |
R938 |
T934 |
T935 |
arg1Of |
Treatment,with |
R93804 |
T93400 |
T81709 |
arg1Of |
N-linked,site-specific |
R93810 |
T74721 |
T38815 |
arg2Of |
application,on |
R93852 |
T46887 |
T7086 |
arg1Of |
sites,ACE2 |
R93854 |
T61083 |
T69286 |
arg2Of |
and,calculated |
R93881 |
T64712 |
T7069 |
arg1Of |
bars,correspond |
R93882 |
T70489 |
T1909 |
arg1Of |
",","," |
R939 |
T937 |
T935 |
arg2Of |
H,with |
R93979 |
T99864 |
T97449 |
arg2Of |
5X59,( |
R94 |
T96 |
T98 |
arg1Of |
clusters,which |
R940 |
T937 |
T936 |
arg1Of |
H,endoglycosidase |
R94025 |
T42122 |
T5756 |
arg1Of |
signal,intensity |
R94049 |
T40461 |
T21664 |
arg2Of |
chymotrypsin,"," |
R94067 |
T55295 |
T15659 |
arg1Of |
proteins,class |
R941 |
T937 |
T938 |
arg1Of |
H,( |
R942 |
T940 |
T938 |
arg2Of |
H,( |
R94202 |
T34645 |
T39600 |
arg1Of |
",","," |
R94234 |
T14034 |
T34347 |
arg2Of |
processing,"," |
R94248 |
T93591 |
T6773 |
arg1Of |
elevated,that |
R94251 |
T84232 |
T65100 |
arg1Of |
"lectins47,48",that |
R94261 |
T35489 |
T78652 |
arg1Of |
S,( |
R94272 |
T85155 |
T10448 |
arg2Of |
able,are |
R94280 |
T25542 |
T79412 |
arg1Of |
coverage,is |
R94295 |
T3010 |
T73014 |
arg3Of |
),( |
R943 |
T941 |
T938 |
arg3Of |
),( |
R94313 |
T13068 |
T77011 |
arg1Of |
functionality,receptor-binding |
R94318 |
T98636 |
T65839 |
arg2Of |
dN/dS,and |
R94357 |
T84155 |
T70958 |
arg1Of |
functions,including |
R94366 |
T75405 |
T78209 |
arg1Of |
differences,the |
R94377 |
T14361 |
T38180 |
arg1Of |
outbreak,viral |
R94385 |
T95787 |
T76751 |
arg1Of |
number,the |
R944 |
T940 |
T939 |
arg1Of |
H,Endo |
R94401 |
T46773 |
T30799 |
arg2Of |
sialylation,and |
R94455 |
T3102 |
T34718 |
arg2Of |
expected,As |
R94460 |
T30036 |
T8007 |
arg1Of |
availability,Code |
R94463 |
T62840 |
T73202 |
arg2Of |
end,To |
R945 |
T934 |
T942 |
arg1Of |
Treatment,revealed |
R94511 |
T37933 |
T54589 |
arg1Of |
and,underscores |
R94531 |
T78585 |
T78948 |
arg2Of |
2.82,with |
R94545 |
T94939 |
T86648 |
arg1Of |
infection,or |
R94567 |
T89162 |
T27010 |
arg1Of |
as,as |
R9457 |
T28413 |
T9951 |
arg1Of |
targets,located |
R94598 |
T8574 |
T91452 |
arg1Of |
highlighted,"," |
R946 |
T944 |
T942 |
arg2Of |
population,revealed |
R94608 |
T61083 |
T3167 |
arg1Of |
and,"," |
R94625 |
T27050 |
T56676 |
arg1Of |
microscopy,cryo-electron |
R94627 |
T13646 |
T96398 |
arg1Of |
glycoprotein,each |
R94664 |
T11314 |
T15501 |
arg2Of |
Env,in |
R94669 |
T80082 |
T99831 |
arg1Of |
glycopeptides,"," |
R947 |
T944 |
T943 |
arg1Of |
population,a |
R94726 |
T79346 |
T67690 |
arg1Of |
route,a |
R94760 |
T65635 |
T5712 |
arg2Of |
lpf,( |
R94768 |
T7775 |
T35432 |
arg2Of |
residues,with |
R948 |
T944 |
T945 |
arg1Of |
population,( |
R94826 |
T80516 |
T31245 |
arg1Of |
aid,from |
R94853 |
T7534 |
T27520 |
arg1Of |
limits,in |
R949 |
T948 |
T945 |
arg2Of |
%,( |
R94942 |
T43233 |
T31301 |
arg1Of |
5X58,and |
R94953 |
T92859 |
T85418 |
arg3Of |
),( |
R95 |
T96 |
T99 |
arg1Of |
clusters,were |
R950 |
T957 |
T945 |
arg3Of |
),( |
R95052 |
T37067 |
T22530 |
arg1Of |
visualized,at |
R95057 |
T60790 |
T18721 |
arg1Of |
domains,the |
R951 |
T948 |
T946 |
arg1Of |
%,SARS |
R95102 |
T12246 |
T58601 |
arg1Of |
sites,( |
R95164 |
T77800 |
T37387 |
arg1Of |
analysis,from |
R952 |
T948 |
T947 |
arg1Of |
%,32.2 |
R95204 |
T52275 |
T93380 |
arg2Of |
reveal,and |
R95247 |
T78856 |
T96785 |
arg1Of |
research,vaccine |
R95251 |
T93319 |
T23715 |
arg1Of |
domains,are |
R95269 |
T84168 |
T46581 |
arg2Of |
glycans,of |
R953 |
T948 |
T949 |
arg1Of |
%,; |
R95337 |
T63927 |
T67674 |
arg1Of |
they,comparable |
R95340 |
T18771 |
T13320 |
arg1Of |
"62/972,886",( |
R95353 |
T29223 |
T90865 |
arg2Of |
glycans,by |
R95367 |
T72680 |
T99216 |
arg1Of |
linked,unknown |
R954 |
T952 |
T949 |
arg2Of |
%,; |
R95483 |
T99824 |
T44869 |
arg1Of |
density,in |
R95498 |
T51670 |
T64487 |
arg1Of |
glycosylated,fully |
R955 |
T952 |
T950 |
arg1Of |
%,MERS |
R95535 |
T97022 |
T63910 |
arg3Of |
),( |
R95558 |
T93082 |
T93681 |
arg2Of |
adding,HAs |
R956 |
T952 |
T951 |
arg1Of |
%,33.8 |
R95696 |
T2440 |
T81945 |
arg1Of |
glycoproteins,MERS |
R957 |
T948 |
T953 |
arg1Of |
%,"," |
R95719 |
T18666 |
T78058 |
arg1Of |
spectrometry,in-line |
R95749 |
T27449 |
T55010 |
arg2Of |
proteins,on |
R95788 |
T76109 |
T52952 |
arg1Of |
undergoing,compared |
R958 |
T956 |
T953 |
arg2Of |
%,"," |
R9580 |
T54076 |
T90081 |
arg1Of |
and,exhibit |
R95802 |
T10907 |
T6763 |
arg1Of |
Hybrid,Hybrid |
R95810 |
T65172 |
T24472 |
arg1Of |
domain,of |
R95827 |
T47420 |
T7804 |
arg1Of |
number,of |
R959 |
T956 |
T954 |
arg1Of |
%,HKU1 |
R95941 |
T20594 |
T87805 |
arg1Of |
residues,be |
R95989 |
T80657 |
T99370 |
arg1Of |
protein,exhibits |
R95997 |
T79677 |
T9355 |
arg1Of |
maps,3D |
R96 |
T100 |
T99 |
arg2Of |
absent,were |
R960 |
T956 |
T955 |
arg1Of |
%,25.0 |
R9602 |
T99144 |
T62580 |
arg1Of |
blue,light |
R96045 |
T68539 |
T1963 |
arg2Of |
glycans,implicated |
R96046 |
T1822 |
T98108 |
arg1Of |
is,"," |
R9606 |
T31709 |
T97881 |
arg1Of |
structure,of |
R96064 |
T83454 |
T45232 |
arg1Of |
pathogens,the |
R96070 |
T38606 |
T52914 |
arg1Of |
GPC,"," |
R96091 |
T76109 |
T71210 |
arg2Of |
undergoing,hypothesized |
R961 |
T944 |
T958 |
arg1Of |
population,of |
R96110 |
T99472 |
T38302 |
arg1Of |
constraints,functional |
R96137 |
T25443 |
T89667 |
arg2Of |
MERS,characterized |
R96156 |
T27449 |
T92344 |
arg1Of |
proteins,S |
R962 |
T961 |
T958 |
arg2Of |
glycans,of |
R96209 |
T72350 |
T71605 |
arg1Of |
consisting,of |
R96223 |
T86793 |
T94778 |
arg1Of |
epitopes,as |
R96288 |
T77242 |
T4847 |
arg1Of |
S,MERS |
R963 |
T961 |
T959 |
arg2Of |
glycans,underprocessed |
R96360 |
T26472 |
T58672 |
arg2Of |
subunit,on |
R964 |
T961 |
T960 |
arg1Of |
glycans,oligomannose-type |
R96485 |
T54715 |
T15304 |
arg1Of |
glycans,were |
R965 |
T961 |
T962 |
arg1Of |
glycans,( |
R96503 |
T27860 |
T30054 |
arg1Of |
events,spillover |
R96524 |
T30435 |
T59632 |
arg2Of |
targeted,unable |
R966 |
T963 |
T962 |
arg2Of |
Fig. 1b,( |
R96646 |
T37271 |
T44204 |
arg1Of |
MSV000084993,//massive.ucsd.edu |
R96677 |
T84994 |
T52429 |
arg1Of |
processing,glycan-influenced |
R967 |
T964 |
T962 |
arg3Of |
),( |
R96790 |
T11163 |
T6955 |
arg1Of |
cells,apart |
R96795 |
T2587 |
T59257 |
arg1Of |
https,: |
R96796 |
T55408 |
T45120 |
arg1Of |
ratio,of |
R96797 |
T64492 |
T50640 |
arg1Of |
",",and |
R96798 |
T11163 |
T61720 |
arg1Of |
cells,HEK293F |
R96799 |
T39465 |
T94895 |
arg1Of |
“shields”,respective |
R968 |
T966 |
T965 |
arg1Of |
observation,This |
R9682 |
T75209 |
T84496 |
arg1Of |
ectodomain52,S |
R96826 |
T29095 |
T83205 |
arg1Of |
group,glycan |
R969 |
T966 |
T967 |
arg1Of |
observation,of |
R96918 |
T17645 |
T70799 |
arg2Of |
sites,of |
R96920 |
T47272 |
T62341 |
arg1Of |
fusion,membrane |
R96993 |
T53941 |
T97382 |
arg1Of |
SOSIP.664,) |
R97 |
T96 |
T100 |
arg1Of |
clusters,absent |
R970 |
T972 |
T967 |
arg2Of |
glycans,of |
R97033 |
T81231 |
T40406 |
arg1Of |
considered,and |
R97035 |
T48849 |
T44931 |
arg1Of |
ecology,transmission |
R971 |
T972 |
T968 |
arg1Of |
glycans,both |
R97100 |
T74594 |
T74197 |
arg1Of |
structure,prefusion |
R97141 |
T81297 |
T83557 |
arg1Of |
surface,the |
R9715 |
T56838 |
T72210 |
arg1Of |
protease,alpha-lytic |
R97186 |
T11869 |
T1640 |
arg1Of |
sites,N-linked |
R97191 |
T11359 |
T98634 |
arg1Of |
consist,"," |
R972 |
T972 |
T969 |
arg1Of |
glycans,complex |
R97236 |
T21025 |
T11498 |
arg1Of |
abundances,were |
R97244 |
T87267 |
T99218 |
arg2Of |
glycans,from |
R97251 |
T93372 |
T85155 |
arg2Of |
accommodate,able |
R97277 |
T22031 |
T84609 |
arg1Of |
analysis,glycopeptide |
R97294 |
T18793 |
T22092 |
arg3Of |
),( |
R973 |
T969 |
T970 |
arg1Of |
complex,and |
R97315 |
T93669 |
T16192 |
arg2Of |
compositions,using |
R9733 |
T26227 |
T71479 |
arg1Of |
abundance,overall |
R97349 |
T86648 |
T2480 |
arg2Of |
or,following |
R974 |
T971 |
T970 |
arg2Of |
oligomannose-type,and |
R975 |
T972 |
T971 |
arg1Of |
glycans,oligomannose-type |
R97505 |
T72666 |
T34571 |
arg1Of |
approach,global |
R976 |
T966 |
T973 |
arg1Of |
observation,reveals |
R97609 |
T74721 |
T47877 |
arg1Of |
application,U.S. |
R97660 |
T46478 |
T75654 |
arg2Of |
domain,for |
R977 |
T982 |
T973 |
arg2Of |
processed,reveals |
R97730 |
T91020 |
T50998 |
arg1Of |
Man9GlcNAc2,to |
R97765 |
T11718 |
T88501 |
arg1Of |
higher,significantly |
R97784 |
T70902 |
T95182 |
arg1Of |
plays,"," |
R978 |
T982 |
T974 |
arg1Of |
processed,that |
R97807 |
T39600 |
T19879 |
arg1Of |
",","," |
R97812 |
T20910 |
T32211 |
arg2Of |
antibodies,elicit |
R97825 |
T3337 |
T52236 |
arg2Of |
shield51,with |
R97857 |
T86129 |
T93372 |
arg1Of |
viruses,accommodate |
R97861 |
T69025 |
T36917 |
arg1Of |
analysis,[ |
R97885 |
T23908 |
T70751 |
arg2Of |
request,upon |
R979 |
T976 |
T975 |
arg1Of |
majority,the |
R9791 |
T66354 |
T6297 |
arg1Of |
shielding,is |
R97915 |
T73292 |
T67434 |
arg1Of |
analysis,of |
R9793 |
T10907 |
T85300 |
arg2Of |
Hybrid,( |
R98 |
T100 |
T101 |
arg1Of |
absent,on |
R980 |
T976 |
T977 |
arg1Of |
majority,of |
R98007 |
T2696 |
T8376 |
arg1Of |
occluded,not |
R98030 |
T78031 |
T72214 |
arg2Of |
Fig. 3b,( |
R981 |
T979 |
T977 |
arg2Of |
glycans,of |
R98141 |
T28342 |
T39391 |
arg1Of |
and,"," |
R98154 |
T18104 |
T34570 |
arg1Of |
terms,of |
R98159 |
T8708 |
T77386 |
arg1Of |
importance,the |
R9817 |
T98975 |
T23520 |
arg1Of |
majority,of |
R9818 |
T9951 |
T30887 |
arg2Of |
located,are |
R98187 |
T72184 |
T26493 |
arg1Of |
extending,from |
R982 |
T979 |
T978 |
arg1Of |
glycans,N-linked |
R98202 |
T70460 |
T30751 |
arg1Of |
clustering,was |
R98204 |
T95495 |
T72291 |
arg3Of |
grey,colored |
R98228 |
T1949 |
T69745 |
arg1Of |
diversity,residue |
R98278 |
T8512 |
T97617 |
arg1Of |
coronaviruses,biomedically |
R98281 |
T51281 |
T32640 |
arg1Of |
as,such |
R98282 |
T15044 |
T80897 |
arg1Of |
and,is |
R98287 |
T61150 |
T11703 |
arg1Of |
A1,to |
R983 |
T976 |
T980 |
arg1Of |
majority,can |
R98318 |
T73857 |
T37469 |
arg1Of |
convolved,and |
R98364 |
T81349 |
T39330 |
arg2Of |
glycosylation,of |
R984 |
T982 |
T980 |
arg2Of |
processed,can |
R98488 |
T46357 |
T51205 |
arg2Of |
differences,observed |
R985 |
T976 |
T981 |
arg1Of |
majority,be |
R98501 |
T97014 |
T28787 |
arg2Of |
response,of |
R986 |
T982 |
T981 |
arg2Of |
processed,be |
R98678 |
T28342 |
T67259 |
arg2Of |
and,on |
R98692 |
T8049 |
T48803 |
arg2Of |
and,of |
R987 |
T976 |
T982 |
arg2Of |
majority,processed |
R98710 |
T93591 |
T90961 |
arg1Of |
elevated,at |
R98729 |
T15993 |
T46581 |
arg1Of |
presence,of |
R988 |
T982 |
T983 |
arg1Of |
processed,"," |
R98810 |
T51881 |
T18623 |
arg2Of |
least,processed |
R98814 |
T42839 |
T28589 |
arg2Of |
building,for |
R98825 |
T72037 |
T77577 |
arg2Of |
most,observed |
R98876 |
T40508 |
T52910 |
arg1Of |
sites,and |
R989 |
T982 |
T984 |
arg1Of |
processed,although |
R98907 |
T16113 |
T48820 |
arg1Of |
panel,a |
R98954 |
T35201 |
T59288 |
arg2Of |
reflected,is |
R98963 |
T80657 |
T67286 |
arg1Of |
protein,viral |
R98976 |
T58744 |
T19935 |
arg1Of |
quality,sufficient |
R98997 |
T38777 |
T13008 |
arg1Of |
densities,of |
R99 |
T103 |
T101 |
arg2Of |
and,on |
R990 |
T986 |
T984 |
arg2Of |
is,although |
R99001 |
T62794 |
T28846 |
arg1Of |
demonstrate,To |
R99054 |
T99144 |
T50978 |
arg2Of |
blue,in |
R9907 |
T3262 |
T30000 |
arg1Of |
glycoproteins,glycan |
R9909 |
T96185 |
T84923 |
arg1Of |
"GPC24,31,34,36,45,46",LASV |
R991 |
T985 |
T986 |
arg1Of |
there,is |
R99133 |
T43250 |
T30395 |
arg2Of |
results,captures |
R99138 |
T68424 |
T76564 |
arg1Of |
We,performed |
R99157 |
T67622 |
T92542 |
arg2Of |
values,of |
R99163 |
T84155 |
T29264 |
arg1Of |
functions,primary |
R99168 |
T63130 |
T89986 |
arg1Of |
surface,the |
R992 |
T988 |
T986 |
arg2Of |
processing,is |
R99203 |
T11359 |
T57335 |
arg1Of |
consist,For |
R99255 |
T29096 |
T93372 |
arg2Of |
modifications,accommodate |
R993 |
T988 |
T987 |
arg1Of |
processing,limited |
R99316 |
T69491 |
T68738 |
arg1Of |
estimates,comparable |
R99324 |
T93327 |
T21412 |
arg2Of |
this,plotted |
R99327 |
T17900 |
T82693 |
arg2Of |
plus,and |
R99353 |
T13646 |
T53031 |
arg1Of |
glycoprotein,respective |
R99358 |
T95681 |
T10473 |
arg1Of |
glycosylated,fully |
R99374 |
T44303 |
T9331 |
arg1Of |
diversity,amino-acid |
R994 |
T988 |
T989 |
arg1Of |
processing,at |
R99404 |
T24622 |
T81145 |
arg1Of |
codes,the |
R99409 |
T19064 |
T16401 |
arg1Of |
HIV,and |
R99431 |
T19047 |
T80136 |
arg1Of |
analysis,Comparative |
R99455 |
T82481 |
T35913 |
arg1Of |
subunit,the |
R99458 |
T32211 |
T66481 |
arg1Of |
elicit,Although |
R99470 |
T45372 |
T96797 |
arg1Of |
tempting,However |
R99471 |
T86172 |
T28589 |
arg1Of |
necessary,for |
R995 |
T991 |
T989 |
arg2Of |
sites,at |
R99511 |
T19047 |
T52944 |
arg1Of |
analysis,of |
R99542 |
T93291 |
T10413 |
arg1Of |
filtering,and |
R99568 |
T84080 |
T83739 |
arg1Of |
changes,in |
R996 |
T991 |
T990 |
arg1Of |
sites,specific |
R99635 |
T88912 |
T28846 |
modOf |
compared,To |
R99636 |
T65162 |
T39172 |
arg1Of |
titres,high |
R99688 |
T30346 |
T55641 |
arg2Of |
sites,of |
R997 |
T991 |
T992 |
arg1Of |
sites,across |
R998 |
T995 |
T992 |
arg2Of |
proteins,across |
R99827 |
T91843 |
T69590 |
arg1Of |
performed,As |
R99845 |
T10448 |
T73121 |
arg2Of |
are,whereas |
R999 |
T995 |
T993 |
arg1Of |
proteins,the |