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PubMed:17981284 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke.
T1 0-111 Sentence denotes Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke.
T2 112-123 Sentence denotes BACKGROUND:
T2 112-123 Sentence denotes BACKGROUND:
T3 124-214 Sentence denotes From initiation to plaque rupture, immune system components contribute to atherosclerosis.
T3 124-214 Sentence denotes From initiation to plaque rupture, immune system components contribute to atherosclerosis.
T4 215-522 Sentence denotes We investigated variation in inflammation-related genes - interleukin (IL)-1beta, IL-6, C-reactive protein (CRP), IL-10, IL-18, and the tumor necrosis factor (TNF) superfamily [lymphotoxin(LT)-alpha, TNF-alpha, LT-beta] - with respect to nonfatal incident myocardial infarction (MI) or ischemic stroke risk.
T4 215-522 Sentence denotes We investigated variation in inflammation-related genes - interleukin (IL)-1beta, IL-6, C-reactive protein (CRP), IL-10, IL-18, and the tumor necrosis factor (TNF) superfamily [lymphotoxin(LT)-alpha, TNF-alpha, LT-beta] - with respect to nonfatal incident myocardial infarction (MI) or ischemic stroke risk.
T5 523-543 Sentence denotes METHODS AND RESULTS:
T5 523-543 Sentence denotes METHODS AND RESULTS:
T6 544-665 Sentence denotes A population-based case-control study recruited postmenopausal and/or hypertensive Group Health members aged 30-79 years.
T6 544-665 Sentence denotes A population-based case-control study recruited postmenopausal and/or hypertensive Group Health members aged 30-79 years.
T7 666-804 Sentence denotes We chose a subset of single nucleotide polymorphisms (SNPs) to describe common gene-wide variation on the basis of linkage disequilibrium.
T7 666-804 Sentence denotes We chose a subset of single nucleotide polymorphisms (SNPs) to describe common gene-wide variation on the basis of linkage disequilibrium.
T8 805-951 Sentence denotes 36 SNPs, describing 38 common haplotypes for 5 genes and a 3-gene cluster, were genotyped among 856 MI cases, 368 stroke cases, and 2688 controls.
T8 805-951 Sentence denotes 36 SNPs, describing 38 common haplotypes for 5 genes and a 3-gene cluster, were genotyped among 856 MI cases, 368 stroke cases, and 2688 controls.
T9 952-1151 Sentence denotes Associations of SNPs or PHASE-inferred haplotypes and risk were estimated using logistic regression; significance of gene-level associations was assessed with global Wald tests and permutation tests.
T9 952-1151 Sentence denotes Associations of SNPs or PHASE-inferred haplotypes and risk were estimated using logistic regression; significance of gene-level associations was assessed with global Wald tests and permutation tests.
T10 1152-1274 Sentence denotes Gene-wide IL-18 variation was associated with higher MI risk and an IL-1B haplotype was associated with lower stroke risk.
T10 1152-1274 Sentence denotes Gene-wide IL-18 variation was associated with higher MI risk and an IL-1B haplotype was associated with lower stroke risk.
T11 1275-1388 Sentence denotes In secondary analyses of SNPs, we observed associations of several IL-1B polymorphisms with risk of MI or stroke.
T11 1275-1388 Sentence denotes In secondary analyses of SNPs, we observed associations of several IL-1B polymorphisms with risk of MI or stroke.
T12 1389-1484 Sentence denotes IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk.
T12 1389-1484 Sentence denotes IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk.
T13 1485-1497 Sentence denotes CONCLUSIONS:
T13 1485-1497 Sentence denotes CONCLUSIONS:
T14 1498-1759 Sentence denotes Our results support prior reports associating an IL-18 gene variant and MI risk, contribute additional evidence to reports of IL-1B and cardiovascular risk, and fail to confirm risk differences previously observed for CRP, IL-6, and TNF-alpha promoter variants.
T14 1498-1759 Sentence denotes Our results support prior reports associating an IL-18 gene variant and MI risk, contribute additional evidence to reports of IL-1B and cardiovascular risk, and fail to confirm risk differences previously observed for CRP, IL-6, and TNF-alpha promoter variants.