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PubMed:16128949 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1 0-75 Sentence denotes Thrombosis in inflammatory bowel diseases: role of inherited thrombophilia.
T1 0-75 Sentence denotes Thrombosis in inflammatory bowel diseases: role of inherited thrombophilia.
T2 76-87 Sentence denotes BACKGROUND:
T2 76-87 Sentence denotes BACKGROUND:
T3 88-196 Sentence denotes Inflammatory bowel diseases (IBD) are characterized by an increased risk for venous and arterial thrombosis.
T3 88-196 Sentence denotes Inflammatory bowel diseases (IBD) are characterized by an increased risk for venous and arterial thrombosis.
T4 197-381 Sentence denotes Although the pathogenetic mechanisms of this predisposition are unclear, a possible role of inherited risk factors for thrombosis in determining this predisposition has been suggested.
T4 197-381 Sentence denotes Although the pathogenetic mechanisms of this predisposition are unclear, a possible role of inherited risk factors for thrombosis in determining this predisposition has been suggested.
T5 382-386 Sentence denotes AIM:
T5 382-386 Sentence denotes AIM:
T6 387-535 Sentence denotes To evaluate the role of factor V Leiden (G1691A) and G20210A prothrombin gene mutations in determining the occurrence of thrombosis in IBD patients.
T6 387-535 Sentence denotes To evaluate the role of factor V Leiden (G1691A) and G20210A prothrombin gene mutations in determining the occurrence of thrombosis in IBD patients.
T7 536-557 Sentence denotes PATIENTS AND METHODS:
T7 536-557 Sentence denotes PATIENTS AND METHODS:
T8 558-741 Sentence denotes Forty-seven IBD patients (30 ulcerative colitis and 17 Crohn's disease) with a positive history for thrombosis (9 at arterial sites and 38 at venous sites) were enrolled in the study.
T8 558-741 Sentence denotes Forty-seven IBD patients (30 ulcerative colitis and 17 Crohn's disease) with a positive history for thrombosis (9 at arterial sites and 38 at venous sites) were enrolled in the study.
T9 742-857 Sentence denotes For each patient, two non-IBD subjects matched for sex and age, type, and site of thrombosis were used as controls.
T9 742-857 Sentence denotes For each patient, two non-IBD subjects matched for sex and age, type, and site of thrombosis were used as controls.
T10 858-1005 Sentence denotes Peripheral blood DNA specimens were amplified by PCR using appropriate primers and analyzed by restriction analysis on agarose gel electrophoresis.
T10 858-1005 Sentence denotes Peripheral blood DNA specimens were amplified by PCR using appropriate primers and analyzed by restriction analysis on agarose gel electrophoresis.
T11 1006-1073 Sentence denotes Statistical analysis was performed by means of Fisher's exact test.
T11 1006-1073 Sentence denotes Statistical analysis was performed by means of Fisher's exact test.
T12 1074-1082 Sentence denotes RESULTS:
T12 1074-1082 Sentence denotes RESULTS:
T13 1083-1289 Sentence denotes The total number of subjects with one or both mutations was significantly lower in IBD patients with thrombosis than in control subjects (12.8%vs 29.8%, respectively; p= 0.035, OR = 0.34, 95% CI 0.13-0.90).
T13 1083-1289 Sentence denotes The total number of subjects with one or both mutations was significantly lower in IBD patients with thrombosis than in control subjects (12.8%vs 29.8%, respectively; p= 0.035, OR = 0.34, 95% CI 0.13-0.90).
T14 1290-1454 Sentence denotes The total frequency of the mutated alleles was also significantly lower in IBD than in controls (7.4%vs 16.5%, respectively; p= 0.041, OR = 0.40, 95% CI 0.17-0.96).
T14 1290-1454 Sentence denotes The total frequency of the mutated alleles was also significantly lower in IBD than in controls (7.4%vs 16.5%, respectively; p= 0.041, OR = 0.40, 95% CI 0.17-0.96).
T15 1455-1684 Sentence denotes Prothrombotic mutations were particularly unfrequent in IBD patients with active disease at the time of thrombosis compared with patients with quiescent disease (8.0%vs 36.4%, respectively; p= 0.057, OR = 0.15, 95% CI 0.02-1.01).
T15 1455-1684 Sentence denotes Prothrombotic mutations were particularly unfrequent in IBD patients with active disease at the time of thrombosis compared with patients with quiescent disease (8.0%vs 36.4%, respectively; p= 0.057, OR = 0.15, 95% CI 0.02-1.01).
T16 1685-1697 Sentence denotes CONCLUSIONS:
T16 1685-1697 Sentence denotes CONCLUSIONS:
T17 1698-2020 Sentence denotes The major inherited risk factors for thrombosis are significantly less frequent in thrombotic IBD patients than in thrombotic non-IBD subjects, suggesting that acquired risk factors play the most relevant role in determining thromboembolic events observed in IBD patients, particularly during active phases of the disease.
T17 1698-2020 Sentence denotes The major inherited risk factors for thrombosis are significantly less frequent in thrombotic IBD patients than in thrombotic non-IBD subjects, suggesting that acquired risk factors play the most relevant role in determining thromboembolic events observed in IBD patients, particularly during active phases of the disease.