Epistemic_Statements  

CORD-19:0b8d789e2116efa9e813dd4763020174f3f26968 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue
T1 170-279 Epistemic_statement denotes The magnetically impregnated tumour cells could then be killed by exposing the tissue to a DC magnetic field.
T2 280-504 Epistemic_statement denotes This is a potentially complementary technique to PDT, as Prasad explained, 'If photodynamic drugs can be encapsulated within such nanoparticles, they can work as dual-killers, by the magnetic as well as photodynamic action.'
T3 505-627 Epistemic_statement denotes So, will PDT finally be associated with words such as 'routine' and 'successful', rather than 'promising' and 'potential'?
T4 913-1007 Epistemic_statement denotes 'If this approach can achieve either of these then that would represent significant progress.'
T5 1008-1151 Epistemic_statement denotes However, he cautioned that without in vivo data, it is not quite clear whether the nanoparticle approach will do everything the authors expect.
T6 1324-1470 Epistemic_statement denotes The Fgl2/fibroleukin protein is also triggered by corona virus in mice, which suggests a possible link to the human corona virus that causes SARS.
T7 1471-1616 Epistemic_statement denotes Almost 80,000 people become infected with hepatitis B virus each year in the USA, despite the fact that it is a vaccine-preventable disease [4] .
T8 1794-1896 Epistemic_statement denotes Chronic hepatitis B virus can often lead to severe complications and death after decades of infection.
T9 1897-2039 Epistemic_statement denotes Fgl2/fibroleukin is an immune coagulant, which can directly cleave prothrombin into thrombin and has the characteristics of a serine protease.
T10 2409-2594 Epistemic_statement denotes For example, an immune response to the virus causes the hepatocellular injury that is associated with hepatitis B virus, rather than direct hepatocellular necrosis induced by the virus.
T11 2743-2995 Epistemic_statement denotes Importantly, the pathways by which vascular thromboses and fibrin generation occurs in viral hepatitis might be mechanistically distinct from the classical pathways of coagulation, which are induced by bacterial lipopolysaccharide or mechanical trauma.
T12 2996-3171 Epistemic_statement denotes The link between Fgl2/fibroleukin and liver disease was identified when a protein with unique clotting ability was isolated from the livers of mice infected with corona virus.
T13 3327-3535 Epistemic_statement denotes Therefore, this new research has generated Fgl2/fibroleukin-deficient mice to further study and define the role of this protein in the initiation and localization of fibrin deposition in viral hepatitis [1] .
T14 4071-4312 Epistemic_statement denotes The study also shows that Fgl2/fibroleukin mRNA expression and protein production varies markedly in patients with chronic viral hepatitis B versus those with minimal chronic viral hepatitis B, being highly correlated with fibrin expression.
T15 4663-4770 Epistemic_statement denotes 'I am excited by this work and believe it will make a real difference to hepatitis patients', says Marsden.
T16 4771-4905 Epistemic_statement denotes The pharmacological blockade of Fgl2/fibroleukin could offer an important new treatment approach in hepatitis B virus-induced disease.
T17 5413-5528 Epistemic_statement denotes While the evidence is compelling, additional work is necessary to determine if this is a safe and effective target.
T18 5529-5715 Epistemic_statement denotes However, these observations lend significant support to arguments that targeting Fgl2/fibroleukin offers a novel method for intervention and treatment for patients with viral hepatitis.'
T19 5837-5947 Epistemic_statement denotes However, as Marsden is keen to stress, there is as yet no direct evidence to link Fgl2/fibroleukin and SARS. '
T20 5948-6084 Epistemic_statement denotes We are now examining patients with SARS for Fgl2 activity and the possible use of neutralizing antibodies for their treatment,' he says.
T21 6239-6498 Epistemic_statement denotes This research opens the way for initial thoughts of a hepatitis treatment by blocking a clotting protein and, if such inhibitors are generated that work in hepatitis patients, perhaps the same inhibitors have the potential to be used in the treatment of SARS.
T22 6499-6500 Epistemic_statement denotes '
T23 6501-6639 Epistemic_statement denotes Marine cyanobacteria are unusual in that they generate molecules in which sub-units of fatty acids are structurally linked to amino acids.
T24 7219-7377 Epistemic_statement denotes The team is also exploring novel 'tailoring' functions by which the cyanobacteria appear to modify the basic polyketide-peptide backbone of these metabolites.
T25 7782-7879 Epistemic_statement denotes Not surprisingly, it turns out that those novel functional groups have novel therapeutic actions.
T26 8259-8414 Epistemic_statement denotes The neurotoxins could turn out to be useful as tool compounds, says Gerwick, because they could act as biochemical inhibitors in the study of cell biology.
T27 8936-9163 Epistemic_statement denotes Although their best success to date has been with compounds isolated from sponges, says Gerwick, new research suggests that some of these might actually have been produced by cyanobacteria living symbiotically with the sponges.