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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-146 Sentence denotes The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications.
T2 147-158 Sentence denotes BACKGROUND:
T3 159-610 Sentence denotes Despite the fact that insertions/deletions (INDELs) are the second most common type of genetic variations and variable number tandem repeats (VNTRs) represent a large portion of the human genome, they have received far less attention than single nucleotide polymorphisms (SNPs) and larger forms of structural variation like copy number variations (CNVs), especially in genome-wide association studies (GWAS) of complex diseases like polygenic obesity.
T4 611-966 Sentence denotes This is exemplified by the vast amount of review papers on the role of SNPs and CNVs in obesity, its related traits (like anthropometric measurements, biochemical variables, and eating behavior), and its related complications (like hypertension, hypertriglyceridemia, hypercholesterolemia, and insulin resistance-collectively known as metabolic syndrome).
T5 967-1116 Sentence denotes Hence, this paper reviews the types of INDELs and VNTRs that have been studied for association with obesity and its related traits and complications.
T6 1117-1317 Sentence denotes These INDELs and VNTRs could be found in the obesity loci or genes from the earliest GWAS and candidate gene association studies, like FTO, genes in the leptin-proopiomelanocortin pathway, and UCP2/3.
T7 1318-1552 Sentence denotes Given the important role of the brain serotonergic and dopaminergic reward system in obesity susceptibility, the association of INDELs and VNTRs in these neurotransmitters' metabolism and transport genes with obesity is also reviewed.
T8 1553-1718 Sentence denotes Next, the role of INS VNTR in obesity and its related traits is questionable, since recent large-scale studies failed to replicate the earlier positive associations.
T9 1719-1917 Sentence denotes As obesity results in chronic low-grade inflammation of the adipose tissue, the proinflammatory cytokine gene IL1RA and anti-inflammatory cytokine gene IL4 have VNTRs that are implicated in obesity.
T10 1918-2110 Sentence denotes A systemic proinflammatory state in combination with activation of the renin-angiotensin system and decreased nitric oxide bioavailability as found in obesity leads to endothelial dysfunction.
T11 2111-2216 Sentence denotes This explains why VNTR and INDEL in eNOS and ACE, respectively, could be predisposing factors of obesity.
T12 2217-2415 Sentence denotes Finally, two novel genes, DOCK5 and PER3, which are involved in the regulation of the Akt/MAPK pathway and circadian rhythm, respectively, have VNTRs and INDEL that might be associated with obesity.
T13 2416-2433 Sentence denotes SHORT CONCLUSION:
T14 2434-2647 Sentence denotes In conclusion, INDELs and VNTRs could have important functional consequences in the pathophysiology of obesity, and research on them should be continued to facilitate obesity prediction, prevention, and treatment.
T1 0-146 Sentence denotes The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications.
T2 147-158 Sentence denotes BACKGROUND:
T3 159-610 Sentence denotes Despite the fact that insertions/deletions (INDELs) are the second most common type of genetic variations and variable number tandem repeats (VNTRs) represent a large portion of the human genome, they have received far less attention than single nucleotide polymorphisms (SNPs) and larger forms of structural variation like copy number variations (CNVs), especially in genome-wide association studies (GWAS) of complex diseases like polygenic obesity.
T4 611-966 Sentence denotes This is exemplified by the vast amount of review papers on the role of SNPs and CNVs in obesity, its related traits (like anthropometric measurements, biochemical variables, and eating behavior), and its related complications (like hypertension, hypertriglyceridemia, hypercholesterolemia, and insulin resistance-collectively known as metabolic syndrome).
T5 967-1116 Sentence denotes Hence, this paper reviews the types of INDELs and VNTRs that have been studied for association with obesity and its related traits and complications.
T6 1117-1317 Sentence denotes These INDELs and VNTRs could be found in the obesity loci or genes from the earliest GWAS and candidate gene association studies, like FTO, genes in the leptin-proopiomelanocortin pathway, and UCP2/3.
T7 1318-1552 Sentence denotes Given the important role of the brain serotonergic and dopaminergic reward system in obesity susceptibility, the association of INDELs and VNTRs in these neurotransmitters' metabolism and transport genes with obesity is also reviewed.
T8 1553-1718 Sentence denotes Next, the role of INS VNTR in obesity and its related traits is questionable, since recent large-scale studies failed to replicate the earlier positive associations.
T9 1719-1917 Sentence denotes As obesity results in chronic low-grade inflammation of the adipose tissue, the proinflammatory cytokine gene IL1RA and anti-inflammatory cytokine gene IL4 have VNTRs that are implicated in obesity.
T10 1918-2110 Sentence denotes A systemic proinflammatory state in combination with activation of the renin-angiotensin system and decreased nitric oxide bioavailability as found in obesity leads to endothelial dysfunction.
T11 2111-2216 Sentence denotes This explains why VNTR and INDEL in eNOS and ACE, respectively, could be predisposing factors of obesity.
T12 2217-2415 Sentence denotes Finally, two novel genes, DOCK5 and PER3, which are involved in the regulation of the Akt/MAPK pathway and circadian rhythm, respectively, have VNTRs and INDEL that might be associated with obesity.
T13 2416-2433 Sentence denotes SHORT CONCLUSION:
T14 2434-2647 Sentence denotes In conclusion, INDELs and VNTRs could have important functional consequences in the pathophysiology of obesity, and research on them should be continued to facilitate obesity prediction, prevention, and treatment.

RDoCTask2SampleData

Id Subject Object Predicate Lexical cue
T1 2217-2415 Most Relevant Sentence for RDoC Construct Circadian Rhythms denotes Finally, two novel genes, DOCK5 and PER3, which are involved in the regulation of the Akt/MAPK pathway and circadian rhythm, respectively, have VNTRs and INDEL that might be associated with obesity.