PubMed:25245883
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/25245883","sourcedb":"PubMed","sourceid":"25245883","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25245883","text":"Single nucleotide polymorphisms of vitamin D binding protein, vitamin D receptor and retinoid X receptor alpha genes and response to hepatitis B vaccination in renal replacement therapy patients.\nAIM: Vitamin D (VD) was recently associated with response to hepatitis B vaccination in chronic kidney disease. We investigated whether polymorphisms in VD binding protein (GC), VD receptor (VDR) and retinoid X receptor α (RXRA) genes were associated with response to hepatitis B vaccination in renal replacement therapy (RRT) patients.\nMETHOD: The study was carried out on 692 responders and 223 non-responders.\nRESULTS: After adjustment for gender, age at the RRT onset, RRT vintage, chronic glomerulonephritis as a cause of renal failure and mean serum parathyroid hormone level, VDR rs1544410 polymorphism was the only one significantly associated with response to hepatitis B vaccination: homozygotes AA (adjusted OR 1.50, 95% CI: 1.17-1.94, p = 0.002) had higher risk to be non-responders than GG homozygotes.\nDISCUSSION: The VDR rs1544410 AA genotype may play a negative role (but not as an independent factor) in determining response to hepatitis B vaccination in RRT patients.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":284,"end":306},"obj":"HP_0012622"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"25245883-5#8#17#geners1544410","span":{"begin":1032,"end":1041},"obj":"geners1544410"},{"id":"25245883-5#117#128#diseaseC0019163","span":{"begin":1141,"end":1152},"obj":"diseaseC0019163"}],"relations":[{"id":"8#17#geners1544410117#128#diseaseC0019163","pred":"associated_with","subj":"25245883-5#8#17#geners1544410","obj":"25245883-5#117#128#diseaseC0019163"}],"attributes":[{"subj":"25245883-5#8#17#geners1544410","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"25245883-5#117#128#diseaseC0019163","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"25245883-0#35#60#gene2638","span":{"begin":35,"end":60},"obj":"gene2638"},{"id":"25245883-0#62#80#gene7421","span":{"begin":62,"end":80},"obj":"gene7421"},{"id":"25245883-0#85#110#gene6256","span":{"begin":85,"end":110},"obj":"gene6256"},{"id":"25245883-0#133#144#diseaseC0019163","span":{"begin":133,"end":144},"obj":"diseaseC0019163"},{"id":"25245883-4#134#153#gene5741","span":{"begin":752,"end":771},"obj":"gene5741"},{"id":"25245883-4#105#118#diseaseC0035078","span":{"begin":723,"end":736},"obj":"diseaseC0035078"},{"id":"25245883-4#247#258#diseaseC0019163","span":{"begin":865,"end":876},"obj":"diseaseC0019163"}],"relations":[{"id":"35#60#gene2638133#144#diseaseC0019163","pred":"associated_with","subj":"25245883-0#35#60#gene2638","obj":"25245883-0#133#144#diseaseC0019163"},{"id":"62#80#gene7421133#144#diseaseC0019163","pred":"associated_with","subj":"25245883-0#62#80#gene7421","obj":"25245883-0#133#144#diseaseC0019163"},{"id":"85#110#gene6256133#144#diseaseC0019163","pred":"associated_with","subj":"25245883-0#85#110#gene6256","obj":"25245883-0#133#144#diseaseC0019163"},{"id":"134#153#gene5741105#118#diseaseC0035078","pred":"associated_with","subj":"25245883-4#134#153#gene5741","obj":"25245883-4#105#118#diseaseC0035078"},{"id":"134#153#gene5741247#258#diseaseC0019163","pred":"associated_with","subj":"25245883-4#134#153#gene5741","obj":"25245883-4#247#258#diseaseC0019163"}],"attributes":[{"subj":"25245883-0#35#60#gene2638","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25245883-0#62#80#gene7421","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25245883-0#85#110#gene6256","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25245883-0#133#144#diseaseC0019163","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25245883-4#134#153#gene5741","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25245883-4#105#118#diseaseC0035078","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25245883-4#247#258#diseaseC0019163","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#ec9793","default":true},{"id":"DisGeNET5_variant_disease","color":"#93a9ec"},{"id":"DisGeNET5_gene_disease","color":"#c3ec93"}]}]}}