Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-75 |
Sentence |
denotes |
Thrombosis in inflammatory bowel diseases: role of inherited thrombophilia. |
T2 |
76-87 |
Sentence |
denotes |
BACKGROUND: |
T3 |
88-196 |
Sentence |
denotes |
Inflammatory bowel diseases (IBD) are characterized by an increased risk for venous and arterial thrombosis. |
T4 |
197-381 |
Sentence |
denotes |
Although the pathogenetic mechanisms of this predisposition are unclear, a possible role of inherited risk factors for thrombosis in determining this predisposition has been suggested. |
T5 |
382-386 |
Sentence |
denotes |
AIM: |
T6 |
387-535 |
Sentence |
denotes |
To evaluate the role of factor V Leiden (G1691A) and G20210A prothrombin gene mutations in determining the occurrence of thrombosis in IBD patients. |
T7 |
536-557 |
Sentence |
denotes |
PATIENTS AND METHODS: |
T8 |
558-741 |
Sentence |
denotes |
Forty-seven IBD patients (30 ulcerative colitis and 17 Crohn's disease) with a positive history for thrombosis (9 at arterial sites and 38 at venous sites) were enrolled in the study. |
T9 |
742-857 |
Sentence |
denotes |
For each patient, two non-IBD subjects matched for sex and age, type, and site of thrombosis were used as controls. |
T10 |
858-1005 |
Sentence |
denotes |
Peripheral blood DNA specimens were amplified by PCR using appropriate primers and analyzed by restriction analysis on agarose gel electrophoresis. |
T11 |
1006-1073 |
Sentence |
denotes |
Statistical analysis was performed by means of Fisher's exact test. |
T12 |
1074-1082 |
Sentence |
denotes |
RESULTS: |
T13 |
1083-1289 |
Sentence |
denotes |
The total number of subjects with one or both mutations was significantly lower in IBD patients with thrombosis than in control subjects (12.8%vs 29.8%, respectively; p= 0.035, OR = 0.34, 95% CI 0.13-0.90). |
T14 |
1290-1454 |
Sentence |
denotes |
The total frequency of the mutated alleles was also significantly lower in IBD than in controls (7.4%vs 16.5%, respectively; p= 0.041, OR = 0.40, 95% CI 0.17-0.96). |
T15 |
1455-1684 |
Sentence |
denotes |
Prothrombotic mutations were particularly unfrequent in IBD patients with active disease at the time of thrombosis compared with patients with quiescent disease (8.0%vs 36.4%, respectively; p= 0.057, OR = 0.15, 95% CI 0.02-1.01). |
T16 |
1685-1697 |
Sentence |
denotes |
CONCLUSIONS: |
T17 |
1698-2020 |
Sentence |
denotes |
The major inherited risk factors for thrombosis are significantly less frequent in thrombotic IBD patients than in thrombotic non-IBD subjects, suggesting that acquired risk factors play the most relevant role in determining thromboembolic events observed in IBD patients, particularly during active phases of the disease. |
T1 |
0-75 |
Sentence |
denotes |
Thrombosis in inflammatory bowel diseases: role of inherited thrombophilia. |
T2 |
76-87 |
Sentence |
denotes |
BACKGROUND: |
T3 |
88-196 |
Sentence |
denotes |
Inflammatory bowel diseases (IBD) are characterized by an increased risk for venous and arterial thrombosis. |
T4 |
197-381 |
Sentence |
denotes |
Although the pathogenetic mechanisms of this predisposition are unclear, a possible role of inherited risk factors for thrombosis in determining this predisposition has been suggested. |
T5 |
382-386 |
Sentence |
denotes |
AIM: |
T6 |
387-535 |
Sentence |
denotes |
To evaluate the role of factor V Leiden (G1691A) and G20210A prothrombin gene mutations in determining the occurrence of thrombosis in IBD patients. |
T7 |
536-557 |
Sentence |
denotes |
PATIENTS AND METHODS: |
T8 |
558-741 |
Sentence |
denotes |
Forty-seven IBD patients (30 ulcerative colitis and 17 Crohn's disease) with a positive history for thrombosis (9 at arterial sites and 38 at venous sites) were enrolled in the study. |
T9 |
742-857 |
Sentence |
denotes |
For each patient, two non-IBD subjects matched for sex and age, type, and site of thrombosis were used as controls. |
T10 |
858-1005 |
Sentence |
denotes |
Peripheral blood DNA specimens were amplified by PCR using appropriate primers and analyzed by restriction analysis on agarose gel electrophoresis. |
T11 |
1006-1073 |
Sentence |
denotes |
Statistical analysis was performed by means of Fisher's exact test. |
T12 |
1074-1082 |
Sentence |
denotes |
RESULTS: |
T13 |
1083-1289 |
Sentence |
denotes |
The total number of subjects with one or both mutations was significantly lower in IBD patients with thrombosis than in control subjects (12.8%vs 29.8%, respectively; p= 0.035, OR = 0.34, 95% CI 0.13-0.90). |
T14 |
1290-1454 |
Sentence |
denotes |
The total frequency of the mutated alleles was also significantly lower in IBD than in controls (7.4%vs 16.5%, respectively; p= 0.041, OR = 0.40, 95% CI 0.17-0.96). |
T15 |
1455-1684 |
Sentence |
denotes |
Prothrombotic mutations were particularly unfrequent in IBD patients with active disease at the time of thrombosis compared with patients with quiescent disease (8.0%vs 36.4%, respectively; p= 0.057, OR = 0.15, 95% CI 0.02-1.01). |
T16 |
1685-1697 |
Sentence |
denotes |
CONCLUSIONS: |
T17 |
1698-2020 |
Sentence |
denotes |
The major inherited risk factors for thrombosis are significantly less frequent in thrombotic IBD patients than in thrombotic non-IBD subjects, suggesting that acquired risk factors play the most relevant role in determining thromboembolic events observed in IBD patients, particularly during active phases of the disease. |