> top > docs > PMC:7361216 > annotations

PMC:7361216 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 2-7 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T2 209-212 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T3 237-243 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T4 384-387 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T5 414-427 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T6 549-562 Body_part denotes myelin sheath http://purl.org/sig/ont/fma/fma62983
T7 577-583 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T8 595-607 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T9 784-790 Body_part denotes lysine http://purl.org/sig/ont/fma/fma82758
T10 791-799 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T11 987-990 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T12 1015-1020 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T13 1047-1060 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T14 1168-1181 Body_part denotes myelin sheath http://purl.org/sig/ont/fma/fma62983
T15 1282-1297 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T16 1462-1469 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T17 1552-1567 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T18 1594-1609 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T19 1623-1630 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T20 1691-1703 Body_part denotes Carbohydrate http://purl.org/sig/ont/fma/fma82737
T21 1742-1750 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T22 1798-1805 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T23 1839-1852 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T24 2090-2103 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T25 2385-2388 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T26 2413-2419 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T27 2648-2660 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T28 2678-2691 Body_part denotes myelin sheath http://purl.org/sig/ont/fma/fma62983
T29 2707-2715 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T30 2762-2770 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T31 2800-2805 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T32 2813-2826 Body_part denotes myelin sheath http://purl.org/sig/ont/fma/fma62983
T33 2910-2925 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T34 3139-3145 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T35 3157-3169 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T36 3295-3298 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T37 3299-3307 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T38 3370-3382 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T39 3459-3478 Body_part denotes natural killer cell http://purl.org/sig/ont/fma/fma63147
T40 3474-3478 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T41 3539-3559 Body_part denotes natural killer cells http://purl.org/sig/ont/fma/fma63147
T42 3554-3559 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T43 3577-3583 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T44 3585-3591 Body_part denotes retina http://purl.org/sig/ont/fma/fma58301
T45 3593-3598 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T46 3600-3608 Body_part denotes prostate http://purl.org/sig/ont/fma/fma9600
T47 3756-3778 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T48 3779-3785 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T49 3962-3965 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T50 3990-3995 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T51 4021-4024 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T52 4161-4164 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T53 4272-4275 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T54 4293-4306 Body_part denotes sciatic nerve http://purl.org/sig/ont/fma/fma19034
T55 4307-4313 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T56 4455-4458 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T57 4527-4530 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T58 4531-4539 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T59 4574-4579 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T60 4647-4650 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T61 4661-4669 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T62 4837-4840 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T63 5043-5055 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T64 5143-5155 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T65 5323-5326 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T66 5420-5423 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T67 5433-5441 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T68 5447-5452 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T69 5487-5495 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T70 5719-5724 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 5742-5745 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T72 5757-5762 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T73 5800-5815 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T74 5810-5815 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 5958-5961 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T76 6096-6109 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T77 6370-6383 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T78 6457-6470 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T79 6585-6588 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T80 6672-6685 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T81 6699-6706 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T82 6726-6734 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T83 6860-6867 Body_part denotes mannose http://purl.org/sig/ont/fma/fma82801
T84 7118-7125 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 7198-7205 Body_part denotes mannose http://purl.org/sig/ont/fma/fma82801
T86 7382-7395 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T87 7431-7438 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 7541-7553 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T89 7697-7709 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T90 7848-7863 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T91 7941-7955 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T92 7996-8008 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T93 8097-8104 Body_part denotes mannose http://purl.org/sig/ont/fma/fma82801
T94 8145-8164 Body_part denotes cerebrospinal fluid http://purl.org/sig/ont/fma/fma20935
T95 8398-8405 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T96 8639-8642 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T97 9089-9092 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 237-243 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T2 414-427 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T3 549-562 Body_part denotes myelin sheath http://purl.obolibrary.org/obo/UBERON_0000347
T4 549-555 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T5 577-583 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T6 1015-1020 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T7 1047-1060 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T8 1168-1181 Body_part denotes myelin sheath http://purl.obolibrary.org/obo/UBERON_0000347
T9 1168-1174 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T10 2413-2419 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T11 2678-2691 Body_part denotes myelin sheath http://purl.obolibrary.org/obo/UBERON_0000347
T12 2678-2684 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T13 2813-2826 Body_part denotes myelin sheath http://purl.obolibrary.org/obo/UBERON_0000347
T14 2813-2819 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T15 3139-3145 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T16 3577-3583 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T17 3585-3591 Body_part denotes retina http://purl.obolibrary.org/obo/UBERON_0000966
T18 3593-3598 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T19 3619-3635 Body_part denotes proximal tubules http://purl.obolibrary.org/obo/UBERON_0004134
T20 3756-3778 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T21 3764-3778 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T22 3779-3785 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T23 3990-3995 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T24 4293-4306 Body_part denotes sciatic nerve http://purl.obolibrary.org/obo/UBERON_0001322
T25 4301-4306 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T26 4307-4313 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T27 5447-5452 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T28 8145-8164 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 40-58 Disease denotes neurologic disease http://purl.obolibrary.org/obo/MONDO_0005071
T2 356-374 Disease denotes neurologic disease http://purl.obolibrary.org/obo/MONDO_0005071
T3 388-409 Disease denotes monoclonal gammopathy http://purl.obolibrary.org/obo/MONDO_0004960
T4 1195-1205 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T5 1586-1593 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 1856-1863 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 2195-2213 Disease denotes neurologic disease http://purl.obolibrary.org/obo/MONDO_0005071
T8 2621-2639 Disease denotes neurologic disease http://purl.obolibrary.org/obo/MONDO_0005071
T9 3118-3128 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T10 3324-3345 Disease denotes monoclonal gammopathy http://purl.obolibrary.org/obo/MONDO_0004960
T11 4025-4035 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T12 4459-4480 Disease denotes monoclonal gammopathy http://purl.obolibrary.org/obo/MONDO_0004960
T13 6171-6181 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T14 6252-6258 Disease denotes ataxia http://purl.obolibrary.org/obo/MONDO_0000437
T15 6526-6534 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 6589-6599 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T17 6710-6718 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 7612-7620 Disease denotes COViD‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 8185-8203 Disease denotes multiple sclerosis http://purl.obolibrary.org/obo/MONDO_0005301
T20 8323-8343 Disease denotes inflammatory disease http://purl.obolibrary.org/obo/MONDO_0021166
T21 8629-8637 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 8643-8664 Disease denotes monoclonal gammopathy http://purl.obolibrary.org/obo/MONDO_0004960
T23 8972-8979 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 9097-9107 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T2 33-34 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 68-69 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 84-85 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 115-116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 349-350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 414-427 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T8 436-437 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 474-479 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T10 498-503 http://purl.obolibrary.org/obo/CLO_0003789 denotes HNK‐1
T11 528-529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 636-637 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 761-762 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 838-843 http://purl.obolibrary.org/obo/CLO_0003789 denotes HNK‐1
T15 1015-1020 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T16 1015-1020 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T17 1032-1042 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T18 1047-1060 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T19 1085-1086 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 1121-1122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 1240-1241 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 1512-1517 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T23 1648-1649 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 1680-1681 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 1729-1730 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 1807-1808 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T27 1890-1895 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T28 1915-1916 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 2188-2189 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 2257-2258 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 2310-2311 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 2558-2559 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 2580-2581 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 2614-2615 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 2646-2647 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 2787-2788 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 2868-2869 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 3102-3103 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T39 3176-3179 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T40 3321-3322 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 3357-3358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 3453-3458 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T43 3459-3478 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cell
T44 3482-3487 http://purl.obolibrary.org/obo/CLO_0003789 denotes HNK‐1
T45 3494-3499 http://purl.obolibrary.org/obo/CLO_0003789 denotes HNK‐1
T46 3539-3559 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cells
T47 3561-3576 http://purl.obolibrary.org/obo/UBERON_0002346 denotes neuroectodermal
T48 3585-3591 http://purl.obolibrary.org/obo/UBERON_0000966 denotes retina
T49 3593-3598 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T50 3593-3598 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T51 3619-3635 http://purl.obolibrary.org/obo/UBERON_0004134 denotes proximal tubules
T52 3669-3670 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 3756-3778 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T54 3756-3778 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T55 3756-3778 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T56 3990-3995 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T57 3990-3995 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T58 3999-4000 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 4001-4006 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T60 4040-4041 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 4301-4306 http://purl.obolibrary.org/obo/UBERON_0001021 denotes nerve
T62 4321-4326 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T63 4327-4335 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primates
T64 4347-4353 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T65 4572-4579 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T66 4993-4994 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 5005-5006 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T68 5035-5036 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 5071-5076 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T70 5124-5125 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T71 5141-5142 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 5162-5168 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T73 5198-5199 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 5239-5244 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T75 5447-5452 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T76 5447-5452 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T77 5460-5465 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T78 5703-5713 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T79 5717-5724 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T80 5736-5741 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T81 5755-5762 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T82 5780-5790 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T83 5800-5815 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T84 5926-5931 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T85 6114-6115 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 6260-6261 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 6387-6388 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 6476-6477 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 6621-6622 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 6829-6830 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91 6904-6905 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 7136-7138 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T93 7344-7345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 7400-7401 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 7450-7451 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 7478-7479 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 7531-7532 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 7730-7731 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 7959-7960 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 8037-8038 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 8216-8222 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T102 8396-8397 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 8465-8471 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T104 8557-8559 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T105 8689-8690 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T106 8891-8892 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 8980-8985 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T108 9014-9015 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 9032-9033 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 9194-9197 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T111 9455-9456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 250-257 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T2 267-279 Chemical denotes glycopolymer http://purl.obolibrary.org/obo/CHEBI_53590|http://purl.obolibrary.org/obo/CHEBI_61420
T4 447-460 Chemical denotes trisaccharide http://purl.obolibrary.org/obo/CHEBI_27150
T5 505-512 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T6 595-607 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T7 784-790 Chemical denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T9 844-857 Chemical denotes trisaccharide http://purl.obolibrary.org/obo/CHEBI_27150
T10 876-882 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T11 896-901 Chemical denotes sulfo http://purl.obolibrary.org/obo/CHEBI_29922
T12 1282-1297 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T13 1423-1434 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T14 1462-1469 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15 1552-1567 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T16 1594-1609 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T17 1623-1630 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T18 1731-1738 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T19 1798-1805 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 1839-1852 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T21 2090-2103 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T22 2426-2433 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T23 2443-2455 Chemical denotes glycopolymer http://purl.obolibrary.org/obo/CHEBI_53590|http://purl.obolibrary.org/obo/CHEBI_61420
T25 2648-2660 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T26 2910-2925 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T27 3157-3169 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T28 3370-3382 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T29 3417-3424 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T30 3500-3507 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T31 3681-3692 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T32 3688-3692 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T33 3851-3857 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T34 3871-3876 Chemical denotes sulfo http://purl.obolibrary.org/obo/CHEBI_29922
T35 4087-4094 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T36 4104-4113 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T37 4800-4807 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T38 4894-4901 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T39 5043-5055 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T40 5143-5155 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T41 5209-5216 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T42 6096-6109 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T43 6126-6133 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T44 6370-6383 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T45 6457-6470 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T46 6672-6685 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T47 6699-6706 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 6726-6734 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T49 6782-6789 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T50 6860-6867 Chemical denotes mannose http://purl.obolibrary.org/obo/CHEBI_37684
T51 6956-6963 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T52 7118-7125 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T53 7198-7205 Chemical denotes mannose http://purl.obolibrary.org/obo/CHEBI_37684
T54 7231-7238 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T55 7382-7395 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T56 7431-7438 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T57 7452-7459 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T58 7460-7468 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T59 7541-7553 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T60 7638-7649 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T61 7697-7709 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T62 7732-7739 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T63 7848-7863 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T64 7941-7955 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T65 7970-7977 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T66 7996-8008 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T67 8097-8104 Chemical denotes mannose http://purl.obolibrary.org/obo/CHEBI_37684
T68 8116-8123 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T69 8291-8298 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T70 8377-8384 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T71 8398-8405 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T72 8406-8413 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T73 8546-8553 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T74 8557-8559 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T1 51-58 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T2 367-374 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T3 1015-1020 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T4 1123-1133 http://purl.obolibrary.org/obo/IDO_0000450 denotes pathogenic
T5 1512-1517 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T6 1769-1784 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T7 1890-1895 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T8 2063-2078 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T9 2146-2153 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T10 2206-2213 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T11 2632-2639 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T12 3261-3268 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T13 3278-3288 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T14 3474-3478 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T15 3554-3559 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T16 3990-3995 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T17 4574-4579 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T18 4618-4625 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T19 4826-4836 http://purl.obolibrary.org/obo/IDO_0000450 denotes pathogenic
T20 4849-4856 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T21 5071-5076 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T22 5447-5452 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T23 5719-5724 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T24 5757-5762 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T25 5810-5815 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T26 6389-6396 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T27 6434-6442 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T28 7154-7159 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T29 7266-7271 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T30 8067-8074 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T31 8336-8343 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T32 8696-8703 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T33 8723-8731 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T34 8799-8806 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T35 8980-8985 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 267-279 Chemical denotes glycopolymer http://purl.obolibrary.org/obo/CHEBI_53590|http://purl.obolibrary.org/obo/CHEBI_61420
T3 447-460 Chemical denotes trisaccharide http://purl.obolibrary.org/obo/CHEBI_27150
T4 595-607 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T5 784-790 Chemical denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T7 844-857 Chemical denotes trisaccharide http://purl.obolibrary.org/obo/CHEBI_27150
T8 876-882 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T9 896-901 Chemical denotes sulfo http://purl.obolibrary.org/obo/CHEBI_29922
T10 963-968 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T11 1282-1297 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T12 1423-1434 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T13 1462-1469 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 1552-1567 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T15 1594-1609 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T16 1623-1630 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 1798-1805 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T18 1839-1852 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T19 2090-2103 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T20 2443-2455 Chemical denotes glycopolymer http://purl.obolibrary.org/obo/CHEBI_53590|http://purl.obolibrary.org/obo/CHEBI_61420
T22 2648-2660 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T23 2910-2925 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T24 3157-3169 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T25 3370-3382 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T26 3681-3692 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T27 3851-3857 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T28 3871-3876 Chemical denotes sulfo http://purl.obolibrary.org/obo/CHEBI_29922
T29 3938-3943 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T30 4231-4236 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T31 4416-4421 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T32 4775-4780 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T33 5043-5055 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T34 5143-5155 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T35 5284-5289 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T36 5683-5688 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T37 5981-5986 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T38 6096-6109 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T39 6370-6383 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T40 6457-6470 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T41 6672-6685 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T42 6699-6706 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 6726-6734 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T44 6782-6789 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T45 6860-6867 Chemical denotes mannose http://purl.obolibrary.org/obo/CHEBI_37684
T46 6956-6963 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T47 7118-7125 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 7198-7205 Chemical denotes mannose http://purl.obolibrary.org/obo/CHEBI_37684
T49 7231-7238 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T50 7382-7395 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T51 7431-7438 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T52 7503-7508 Chemical denotes PPSGG http://purl.obolibrary.org/obo/CHEBI_137080
T53 7541-7553 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T54 7638-7649 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T55 7697-7709 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T56 7848-7863 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T57 7941-7955 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T58 7996-8008 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T59 8097-8104 Chemical denotes mannose http://purl.obolibrary.org/obo/CHEBI_37684
T60 8116-8123 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T61 8377-8384 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T62 8398-8405 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T63 8546-8553 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T1 139-147 Species denotes CoViD‐19 NCBItxid:2697049
T2 474-479 Species denotes Human NCBItxid:9606
T3 1357-1365 Species denotes CoViD‐19 NCBItxid:2697049
T4 1586-1593 Species denotes COVID19 NCBItxid:2697049
T5 1856-1863 Species denotes COVID19 NCBItxid:2697049
T6 2985-2993 Species denotes CoViD‐19 NCBItxid:2697049
T7 3453-3458 Species denotes human NCBItxid:9606
T8 4001-4006 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T10 4321-4326 Species denotes human NCBItxid:9606
T11 4327-4335 Species denotes primates NCBItxid:9443
T12 5239-5244 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T14 5460-5465 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T16 5736-5741 Species denotes human NCBItxid:9606
T17 5926-5931 Species denotes human NCBItxid:9606
T18 6526-6534 Species denotes COVID‐19 NCBItxid:2697049
T19 6710-6718 Species denotes COVID‐19 NCBItxid:2697049
T20 6831-6849 Species denotes feline coronavirus NCBItxid:12663
T21 7612-7620 Species denotes COViD‐19 NCBItxid:2697049
T22 8629-8637 Species denotes COVID‐19 NCBItxid:2697049
T23 8972-8979 Species denotes COVID19 NCBItxid:2697049
T24 9141-9149 Species denotes CoVID‐19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes A sugar‐coated strategy to treat a rare neurologic disease provides a blueprint for a decoy glycan therapeutic and a potential vaccine for CoViD‐19
T2 148-316 Sentence denotes An Editorial Highlight for “Selective inhibition of anti‐MAG IgM autoantibody binding to myelin by an antigen specific glycopolymer”on https://doi.org/10.1111/jnc.15021
T3 317-325 Sentence denotes STEINMAN
T4 327-335 Sentence denotes Abstract
T5 336-344 Sentence denotes Abstract
T6 346-609 Sentence denotes In a rare neurologic disease known as IgM monoclonal gammopathy the immune system targets a sulfated trisaccharide known as the Human Natural Killer‐1 (HNK‐1) epitope that comprises a constituent of the myelin sheath known as MAG (myelin‐associated glycoprotein).
T7 610-1061 Sentence denotes This Editorial highlights a study by Aliu and colleagues in the current issue of the Journal of Neurochemistry, in which the investigators constructed a biodegradable poly‐l‐lysine backbone with multiple copies of this sulfated HNK‐1 trisaccharide. This decoy, poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside, known as PPSGG, removed anti‐MAG IgM autoantibodies from the blood, while not activating the immune system.
T8 1062-1206 Sentence denotes These findings provide a path for the selective removal of a pathogenic set of antibodies that target the myelin sheath resulting in neuropathy.
T9 1207-1525 Sentence denotes These findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor‐binding domain of CoViD‐19, which might inhibit viral adhesion to its receptor, the angiotensin‐converting enzyme‐2 (ACE2) protein, thereby impairing cellular uptake of the virus itself.
T10 1526-1690 Sentence denotes The deployment of complex polysaccharides that mimic actual COVID19 polysaccharides on the spike protein may also provide a feasible structural basis for a vaccine.
T11 1691-1806 Sentence denotes Carbohydrate mimics, if conjugated to a carrier or backbone, might provoke an immune response to the spike protein.
T12 1807-2037 Sentence denotes A vaccine that targets critical carbohydrates on COVID19, and then neutralizes the virus would recapitulate a successful strategy employed in other microbial vaccines, like the pneumococcal vaccines and the meningococcal vaccines.
T13 2038-2154 Sentence denotes These vaccines direct an immune response to complex carbohydrates and successfully prevent life‐threatening disease.
T14 2155-2275 Sentence denotes This paper provides lessons from a rare neurologic disease that may teach us strategies applicable to a global pandemic.
T15 2277-2716 Sentence denotes The present Editorial highlights a study by Aliu and colleagues, entitled “Selective inhibition of anti‐MAG IgM autoantibody binding to myelin by an antigen specific glycopolymer” published in the current issue of the Journal of Neurochemistry, in which the authors have developed a therapy directed to a highly specific target to treat a rare neurologic disease where a carbohydrate component of the myelin sheath is attacked by antibody.
T16 2717-2827 Sentence denotes The targeted therapy specifically blocks the antibody from binding to a particular sugar on the myelin sheath.
T17 2828-3084 Sentence denotes The authors' findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor‐binding domain of CoViD‐19, which might inhibit viral adhesion to its receptor and thus lead the way toward vaccines.
T18 3086-3101 Sentence denotes 1 INTRODUCTION
T19 3102-3252 Sentence denotes A demyelinating neuropathy targeting myelin‐associated glycoprotein (MAG) has an incidence of approximately one per 100,000 (Mygland & Monstad, 2001).
T20 3253-3489 Sentence denotes In this disease there is production of an IgM antibody resulting in a “monoclonal gammopathy” targeting a particular carbohydrate known as Cellular Differentiation antigen 57 (CD57) and also known as human natural killer cell‐1 (HNK‐1).
T21 3490-3652 Sentence denotes The HNK‐1 antigen is found on MAG, as well as on natural killer cells, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules (Pernick, 2019).
T22 3653-3786 Sentence denotes CD57 belongs to a family of sialic acid‐binding Ig‐like lectins (siglecs) found on both peripheral and central nervous system myelin.
T23 3787-4036 Sentence denotes In this issue investigators (Aliu et al, 2020) showed that poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside, known as PPSGG, removed anti‐MAG IgM autoantibodies from the blood in a mouse model of this IgM neuropathy.
T24 4037-4192 Sentence denotes In a previous study these investigators developed antigen‐specific molecules with nanomolar inhibitory potency for anti‐MAG IgM (Herrendorff et al., 2017).
T25 4193-4336 Sentence denotes Here the investigators also show that PPSGG blocked the binding of an anti‐MAG IgM from patients to sciatic nerve myelin of non‐human primates.
T26 4337-4422 Sentence denotes They also tested some of the pharmacokinetic and pharmacodynamic properties of PPSGG.
T27 4423-4595 Sentence denotes In patients suffering from this IgM monoclonal gammopathy, non‐specific strategies are used to diminish IgM antibody including targeting of all CD20 B cells with Rituximab.
T28 4596-4747 Sentence denotes On occasion flares of disease occur with increased IgM levels of antibody targeting MAG have followed therapy with Rituximab (Broglio and Luria, 2005).
T29 4748-4857 Sentence denotes The strategy employed with PPSGG is specific to the antigen that triggers the pathogenic IgM in this disease.
T30 4858-4937 Sentence denotes One can refer to such treatment as “antigen‐specific” immunotherapy (Figure 1).
T31 4938-5345 Sentence denotes FIGURE 1 The strategy employed by Aliu et al, provide a basis for a passive immune therapy with a decoy carbohydrate preventing the virus from docking on its receptor, and also provide a foundation for a carbohydrate‐based active immunization when coupled to a suitable carrier Investigations in the mouse model revealed that practical doses of PPSGG were able to sufficiently reduce IgM that binds to MAG.
T32 5346-5472 Sentence denotes Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model.
T33 5473-5622 Sentence denotes Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach.
T34 5623-5763 Sentence denotes In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells.
T35 5764-5829 Sentence denotes In addition, no activation of CD11b dendritic cells was observed.
T36 5830-5948 Sentence denotes These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials.
T37 5949-6041 Sentence denotes Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study.
T38 6042-6326 Sentence denotes Writing about these exquisite approaches to targeting carbohydrates for a potential antigen‐specific therapy for an inflammatory neuropathy characterized by sensory impairment, disturbance in gait, tremor, and ataxia (a form of incoordination following sensory loss) makes one wonder:
T39 6327-6504 Sentence denotes Could such an approach, targeting critical carbohydrates in a disease, have broader applicability to other diseases where complex carbohydrates play a key pathophysiologic role?
T40 6505-6719 Sentence denotes In these days of the COVID‐19 pandemic, the experiments described on monoclonal IgM neuropathy raise the issue that a similar strategy might be deployed to target the carbohydrates in the spike protein of COVID‐19.
T41 6720-6790 Sentence denotes Spike proteins in coronviruses are known to be camouflaged by glycans:
T42 6791-6939 Sentence denotes Mass spectrometry studies revealed in a feline coronavirus that high mannose and complex N‐Glycans accounted for a quarter of the mass of the spike.
T43 6940-7063 Sentence denotes Moreover, the N‐glycans are critical for providing the propeller like conformation of these structures (Yang et al., 2020).
T44 7064-7185 Sentence denotes In the so‐called receptor‐binding domain of the spike protein there are 22 glycan‐binding sites (Shahajan, Supekar et al.
T45 7186-7192 Sentence denotes 2020).
T46 7193-7316 Sentence denotes High mannose, hybrid and complex‐type glycans across the N‐glycosylation sites have been identified with mass spectrometry.
T47 7317-7525 Sentence denotes One could imagine building a therapeutic which might contain the carbohydrates, or a suitable mimic, of the spike protein coupled to a carrier molecule, much in a similar fashion to how PPSGG was constructed.
T48 7526-7677 Sentence denotes Such a “decoy” carbohydrate could block the binding and subsequent internalization of COViD‐19 to its receptor, angiotensin converting enzyme‐2 (ACE2).
T49 7678-7779 Sentence denotes In addition, spike carbohydrate clusters coupled to a carrier might proof to be an effective vaccine.
T50 7780-7912 Sentence denotes Both the pneumococcal vaccine and the meningococcal vaccines target polysaccharides in pneumococcus and meningococcus, respectively.
T51 7913-8033 Sentence denotes They couple the appropriate polysaccharide to a suitable carrier to achieve potent carbohydrate‐specific immunogenicity.
T52 8034-8253 Sentence denotes In a different neuroinflammatory disease antibodies to cryptic mannose containing glycans were observed in the cerebrospinal fluid of individuals with multiple sclerosis, and in its animal model EAE (Wang et al., 2014).
T53 8254-8344 Sentence denotes There again is some precedent for an antigen‐specific therapy for an inflammatory disease.
T54 8345-8496 Sentence denotes Injection of these oligomannose glycans coupled to a protein carrier reduced the clinical severity of paralysis in this animal model (Wang, Bhat et al.
T55 8497-8503 Sentence denotes 2014).
T56 8504-8638 Sentence denotes The success in parlaying the oligomannose glycans in MS and in its EAE model, could be emulated in strategies for therapy of COVID‐19.
T57 8639-8704 Sentence denotes IgM monoclonal gammopathy targeting MAG is indeed a rare disease.
T58 8705-8807 Sentence denotes Lessons from rare diseases often inform us of bold approaches for the treatment of widespread disease.
T59 8808-8986 Sentence denotes The pioneering work of Aliu and colleagues described in this issue, might serve as a guidepost for designing effective therapeutics to the glycan components of the COVID19 virus.
T60 8987-9159 Sentence denotes Such endeavors may produce a sweet ending to a tragedy including both the harsh clinical realities of IgM MAG neuropathy and to the horrors of the deadly CoVID‐19 pandemic.
T61 9161-9182 Sentence denotes CONFLICTS OF INTEREST
T62 9183-9233 Sentence denotes The author has no conflict of interest to declare.
T63 9235-9250 Sentence denotes ACKNOWLEDGMENTS
T64 9251-9298 Sentence denotes This work was supported by NIH 2U01AI101984‐06.
T65 9299-9357 Sentence denotes Editorial advice from Dr Jonathan Steinman is appreciated.
T66 9358-9486 Sentence denotes The figure was re‐drawn in BioRender (https://biorender.com/) by Marco Bazelmans on the basis of a draft provided by the author.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 237-243 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T2 414-427 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T3 549-562 Body_part denotes myelin sheath http://purl.obolibrary.org/obo/UBERON_0000347
T4 577-583 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T5 1015-1020 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 1047-1060 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T7 1168-1181 Body_part denotes myelin sheath http://purl.obolibrary.org/obo/UBERON_0000347
T8 2413-2419 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T9 2678-2691 Body_part denotes myelin sheath http://purl.obolibrary.org/obo/UBERON_0000347
T10 2813-2826 Body_part denotes myelin sheath http://purl.obolibrary.org/obo/UBERON_0000347
T11 3139-3145 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T12 3577-3583 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T13 3585-3591 Body_part denotes retina http://purl.obolibrary.org/obo/UBERON_0000966
T14 3593-3598 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T15 3619-3635 Body_part denotes proximal tubules http://purl.obolibrary.org/obo/UBERON_0004134
T16 3756-3778 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T17 3779-3785 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T18 3990-3995 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T19 4293-4306 Body_part denotes sciatic nerve http://purl.obolibrary.org/obo/UBERON_0001322
T20 4307-4313 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T21 5447-5452 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T22 8145-8164 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
4 40-58 Disease denotes neurologic disease MESH:D020271
3 86-98 Chemical denotes decoy glycan
5 139-147 Disease denotes CoViD‐19 MESH:C000657245
53 356-374 Disease denotes neurologic disease MESH:D020271
42 447-460 Chemical denotes trisaccharide MESH:D014312
33 498-503 Gene denotes HNK‐1 Gene:27087
34 572-575 Gene denotes MAG Gene:4099
35 577-607 Gene denotes myelin‐associated glycoprotein Gene:4099
43 777-790 Chemical denotes poly‐l‐lysine
36 838-843 Gene denotes HNK‐1 Gene:27087
44 844-857 Chemical denotes trisaccharide MESH:D014312
45 871-952 Chemical denotes poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside
46 963-968 Chemical denotes PPSGG
41 983-986 Gene denotes MAG Gene:4099
54 1195-1205 Disease denotes neuropathy MESH:D009422
47 1282-1297 Chemical denotes polysaccharides MESH:D011134
55 1357-1365 Disease denotes CoViD‐19 MESH:C000657245
37 1423-1454 Gene denotes angiotensin‐converting enzyme‐2 Gene:59272
38 1456-1460 Gene denotes ACE2 Gene:59272
48 1552-1567 Chemical denotes polysaccharides MESH:D011134
49 1586-1609 Chemical denotes COVID19 polysaccharides
39 1617-1622 Gene denotes spike Gene:43740568
50 1691-1703 Chemical denotes Carbohydrate MESH:D002241
40 1792-1797 Gene denotes spike Gene:43740568
51 1839-1852 Chemical denotes carbohydrates MESH:D002241
56 1856-1863 Disease denotes COVID19 MESH:C000657245
57 1984-1996 Disease denotes pneumococcal MESH:D011008
58 2014-2027 Disease denotes meningococcal MESH:D008589
52 2090-2103 Chemical denotes carbohydrates MESH:D002241
59 2195-2213 Disease denotes neurologic disease MESH:D020271
66 2381-2384 Gene denotes MAG Gene:4099
70 2621-2639 Disease denotes neurologic disease MESH:D020271
67 2648-2660 Chemical denotes carbohydrate MESH:D002241
68 2800-2805 Chemical denotes sugar MESH:D000073893
69 2910-2925 Chemical denotes polysaccharides MESH:D011134
71 2985-2993 Disease denotes CoViD‐19 MESH:C000657245
90 3104-3128 Disease denotes demyelinating neuropathy MESH:D003711
82 3139-3169 Gene denotes myelin‐associated glycoprotein Gene:4099
85 3171-3174 Gene denotes MAG Gene:4099
88 3370-3382 Chemical denotes carbohydrate MESH:D002241
87 3453-3458 Species denotes human Tax:9606
83 3482-3487 Gene denotes HNK‐1 Gene:27087
84 3494-3499 Gene denotes HNK‐1 Gene:27087
86 3520-3523 Gene denotes MAG Gene:4099
89 3681-3692 Chemical denotes sialic acid MESH:D019158
91 3756-3785 Disease denotes central nervous system myelin MESH:D020278
110 3846-3899 Chemical denotes poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)
111 3900-3927 Chemical denotes (1→3)‐β‐d‐galactopyranoside
112 3938-3943 Chemical denotes PPSGG
106 3958-3961 Gene denotes MAG Gene:17136
107 4001-4006 Species denotes mouse Tax:10090
115 4021-4035 Disease denotes IgM neuropathy MESH:D053306
105 4157-4160 Gene denotes MAG Gene:17136
113 4231-4236 Chemical denotes PPSGG
104 4268-4271 Gene denotes MAG Gene:4099
108 4281-4289 Species denotes patients Tax:9606
109 4321-4326 Species denotes human Tax:9606
114 4416-4421 Chemical denotes PPSGG
122 4426-4434 Species denotes patients Tax:9606
123 4585-4594 Chemical denotes Rituximab MESH:D000069283
121 4680-4683 Gene denotes MAG Gene:4099
124 4711-4720 Chemical denotes Rituximab MESH:D000069283
125 4775-4780 Chemical denotes PPSGG
128 5037-5055 Chemical denotes decoy carbohydrate
129 5143-5155 Chemical denotes carbohydrate MESH:D002241
146 5239-5244 Species denotes mouse Tax:10090
150 5284-5289 Chemical denotes PPSGG
145 5341-5344 Gene denotes MAG Gene:17136
144 5429-5432 Gene denotes MAG Gene:17136
147 5460-5465 Species denotes mouse Tax:10090
151 5683-5688 Chemical denotes PPSGG
149 5736-5741 Species denotes human Tax:9606
143 5751-5754 Gene denotes MAG Gene:4099
141 5794-5799 Gene denotes CD11b Gene:3684
148 5926-5931 Species denotes human Tax:9606
142 5972-5975 Gene denotes MAG Gene:4099
166 6096-6109 Chemical denotes carbohydrates MESH:D002241
170 6171-6181 Disease denotes neuropathy MESH:D009422
171 6199-6217 Disease denotes sensory impairment MESH:D012678
172 6240-6246 Disease denotes tremor MESH:D014202
173 6252-6258 Disease denotes ataxia MESH:D001259
174 6270-6284 Disease denotes incoordination MESH:D001259
167 6370-6383 Chemical denotes carbohydrates MESH:D002241
168 6457-6470 Chemical denotes carbohydrates MESH:D002241
175 6526-6534 Disease denotes COVID‐19 MESH:C000657245
176 6585-6599 Disease denotes IgM neuropathy MESH:D053306
169 6672-6685 Chemical denotes carbohydrates MESH:D002241
165 6693-6698 Gene denotes spike Gene:43740568
177 6710-6718 Disease denotes COVID‐19 MESH:C000657245
185 6720-6725 Gene denotes Spike Gene:43740568
188 6782-6789 Chemical denotes glycans MESH:D011134
187 6831-6849 Species denotes feline coronavirus Tax:12663
189 6860-6867 Chemical denotes mannose MESH:D008358
190 6880-6889 Chemical denotes N‐Glycans
186 6933-6938 Gene denotes spike Gene:43740568
191 6954-6963 Chemical denotes N‐glycans
212 7112-7117 Gene denotes spike Gene:43740568
217 7139-7145 Chemical denotes glycan MESH:D011134
218 7198-7205 Chemical denotes mannose MESH:D008358
219 7231-7238 Chemical denotes glycans MESH:D011134
220 7250-7251 Chemical denotes N MESH:D009584
221 7382-7395 Chemical denotes carbohydrates MESH:D002241
213 7425-7430 Gene denotes spike Gene:43740568
222 7503-7508 Chemical denotes PPSGG
223 7534-7553 Chemical denotes decoy” carbohydrate
228 7612-7620 Disease denotes COViD‐19 MESH:C000657245
214 7638-7669 Gene denotes angiotensin converting enzyme‐2 Gene:59272
215 7671-7675 Gene denotes ACE2 Gene:59272
216 7691-7696 Gene denotes spike Gene:43740568
224 7697-7709 Chemical denotes carbohydrate MESH:D002241
229 7789-7801 Disease denotes pneumococcal MESH:D011008
230 7818-7831 Disease denotes meningococcal MESH:D008589
225 7848-7863 Chemical denotes polysaccharides MESH:D011134
231 7867-7897 Disease denotes pneumococcus and meningococcus
226 7941-7955 Chemical denotes polysaccharide MESH:D011134
227 7996-8008 Chemical denotes carbohydrate MESH:D002241
246 8049-8074 Disease denotes neuroinflammatory disease MESH:D003141
241 8089-8096 Gene denotes cryptic Gene:55997
242 8097-8104 Chemical denotes mannose MESH:D008358
243 8116-8123 Chemical denotes glycans MESH:D011134
247 8185-8203 Disease denotes multiple sclerosis MESH:D009103
244 8364-8384 Chemical denotes oligomannose glycans
248 8447-8456 Disease denotes paralysis MESH:D010243
245 8533-8553 Chemical denotes oligomannose glycans
249 8629-8637 Disease denotes COVID‐19 MESH:C000657245
256 8675-8678 Gene denotes MAG Gene:4099
258 8831-8835 Chemical denotes Aliu
259 8947-8953 Chemical denotes glycan MESH:D011134
257 8972-8985 Species denotes COVID19 virus Tax:2697049
260 9089-9107 Disease denotes IgM MAG neuropathy MESH:D053306
261 9141-9149 Disease denotes CoVID‐19 MESH:C000657245

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1 205-208 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T2 572-575 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T3 577-607 Protein denotes myelin‐associated glycoprotein https://www.uniprot.org/uniprot/Q567S4|https://www.uniprot.org/uniprot/Q15489|https://www.uniprot.org/uniprot/P20917|https://www.uniprot.org/uniprot/P20916|https://www.uniprot.org/uniprot/P16880|https://www.uniprot.org/uniprot/P07723|https://www.uniprot.org/uniprot/P07722|https://www.uniprot.org/uniprot/P02685|https://www.uniprot.org/uniprot/F5GYC0|https://www.uniprot.org/uniprot/B7Z2E5|https://www.uniprot.org/uniprot/A0A087WPR1
T14 983-986 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T15 1423-1454 Protein denotes angiotensin‐converting enzyme‐2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T30 1456-1460 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T31 1617-1630 Protein denotes spike protein https://www.uniprot.org/uniprot/P31340
T32 1792-1805 Protein denotes spike protein https://www.uniprot.org/uniprot/P31340
T33 2381-2384 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T34 3139-3169 Protein denotes myelin‐associated glycoprotein https://www.uniprot.org/uniprot/Q567S4|https://www.uniprot.org/uniprot/Q15489|https://www.uniprot.org/uniprot/P20917|https://www.uniprot.org/uniprot/P20916|https://www.uniprot.org/uniprot/P16880|https://www.uniprot.org/uniprot/P07723|https://www.uniprot.org/uniprot/P07722|https://www.uniprot.org/uniprot/P02685|https://www.uniprot.org/uniprot/F5GYC0|https://www.uniprot.org/uniprot/B7Z2E5|https://www.uniprot.org/uniprot/A0A087WPR1
T45 3171-3174 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T46 3520-3523 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T47 3958-3961 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T48 4157-4160 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T49 4268-4271 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T50 4567-4571 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4
T57 4680-4683 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T58 5341-5344 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T59 5429-5432 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T60 5751-5754 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T61 5794-5799 Protein denotes CD11b https://www.uniprot.org/uniprot/Q8CA73|https://www.uniprot.org/uniprot/Q4VAK2|https://www.uniprot.org/uniprot/Q4VAK1|https://www.uniprot.org/uniprot/Q4VAK0|https://www.uniprot.org/uniprot/P11578|https://www.uniprot.org/uniprot/P11215|https://www.uniprot.org/uniprot/P05555
T68 5972-5975 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T69 6693-6706 Protein denotes spike protein https://www.uniprot.org/uniprot/P31340
T70 6720-6734 Protein denotes Spike proteins https://www.uniprot.org/uniprot/P31340
T71 7112-7125 Protein denotes spike protein https://www.uniprot.org/uniprot/P31340
T72 7425-7438 Protein denotes spike protein https://www.uniprot.org/uniprot/P31340
T73 7638-7669 Protein denotes angiotensin converting enzyme‐2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T88 7671-7675 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T89 8396-8405 Protein denotes a protein https://www.uniprot.org/uniprot/Q38365|https://www.uniprot.org/uniprot/P25244|https://www.uniprot.org/uniprot/P25243|https://www.uniprot.org/uniprot/P15966|https://www.uniprot.org/uniprot/P09676|https://www.uniprot.org/uniprot/P07394|https://www.uniprot.org/uniprot/P03632|https://www.uniprot.org/uniprot/P03610|https://www.uniprot.org/uniprot/O64306
T98 8675-8678 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4
T99 9093-9096 Protein denotes MAG https://www.uniprot.org/uniprot/Q567S4

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T1 2-7 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T2 209-212 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T3 237-243 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T4 384-387 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T5 414-427 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T6 549-562 Body_part denotes myelin sheath http://purl.org/sig/ont/fma/fma62983
T7 577-583 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T8 595-607 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T9 784-790 Body_part denotes lysine http://purl.org/sig/ont/fma/fma82758
T10 791-799 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T11 987-990 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T12 1015-1020 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T13 1047-1060 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T14 1168-1181 Body_part denotes myelin sheath http://purl.org/sig/ont/fma/fma62983
T15 1282-1297 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T16 1462-1469 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T17 1552-1567 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T18 1594-1609 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T19 1623-1630 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T20 1691-1703 Body_part denotes Carbohydrate http://purl.org/sig/ont/fma/fma82737
T21 1742-1750 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T22 1798-1805 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T23 1839-1852 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T24 2090-2103 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T25 2385-2388 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T26 2413-2419 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T27 2648-2660 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T28 2678-2691 Body_part denotes myelin sheath http://purl.org/sig/ont/fma/fma62983
T29 2707-2715 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T30 2762-2770 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T31 2800-2805 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T32 2813-2826 Body_part denotes myelin sheath http://purl.org/sig/ont/fma/fma62983
T33 2910-2925 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T34 3139-3145 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T35 3157-3169 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T36 3295-3298 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T37 3299-3307 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T38 3370-3382 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T39 3459-3478 Body_part denotes natural killer cell http://purl.org/sig/ont/fma/fma63147
T40 3474-3478 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T41 3539-3559 Body_part denotes natural killer cells http://purl.org/sig/ont/fma/fma63147
T42 3554-3559 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T43 3577-3583 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T44 3585-3591 Body_part denotes retina http://purl.org/sig/ont/fma/fma58301
T45 3593-3598 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T46 3600-3608 Body_part denotes prostate http://purl.org/sig/ont/fma/fma9600
T47 3756-3778 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T48 3779-3785 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T49 3962-3965 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T50 3990-3995 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T51 4021-4024 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T52 4161-4164 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T53 4272-4275 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T54 4293-4306 Body_part denotes sciatic nerve http://purl.org/sig/ont/fma/fma19034
T55 4307-4313 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T56 4455-4458 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T57 4527-4530 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T58 4531-4539 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T59 4574-4579 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T60 4647-4650 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T61 4661-4669 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T62 4837-4840 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T63 5043-5055 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T64 5143-5155 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T65 5323-5326 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T66 5420-5423 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T67 5433-5441 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T68 5447-5452 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T69 5487-5495 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T70 5719-5724 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 5742-5745 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T72 5757-5762 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T73 5800-5815 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T74 5810-5815 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 5958-5961 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T76 6096-6109 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T77 6370-6383 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T78 6457-6470 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T79 6585-6588 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T80 6672-6685 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T81 6699-6706 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T82 6726-6734 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T83 6860-6867 Body_part denotes mannose http://purl.org/sig/ont/fma/fma82801
T84 7118-7125 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 7198-7205 Body_part denotes mannose http://purl.org/sig/ont/fma/fma82801
T86 7382-7395 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T87 7431-7438 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 7541-7553 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T89 7697-7709 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T90 7848-7863 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T91 7941-7955 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T92 7996-8008 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T93 8097-8104 Body_part denotes mannose http://purl.org/sig/ont/fma/fma82801
T94 8145-8164 Body_part denotes cerebrospinal fluid http://purl.org/sig/ont/fma/fma20935
T95 8398-8405 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T96 8639-8642 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T97 9089-9092 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T1 1015-1020 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 1015-1020 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 3585-3591 http://purl.obolibrary.org/obo/MAT_0000142 denotes retina
T4 3593-3598 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T5 3600-3608 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T6 3619-3627 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T7 3756-3778 http://purl.obolibrary.org/obo/MAT_0000457 denotes central nervous system
T8 3764-3778 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system
T9 3990-3995 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T10 3990-3995 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T11 5447-5452 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T12 5447-5452 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T13 8145-8164 http://purl.obolibrary.org/obo/MAT_0000499 denotes cerebrospinal fluid

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T1 1498-1504 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T2 1769-1784 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T3 2063-2078 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T4 3756-3785 http://purl.obolibrary.org/obo/GO_0022010 denotes central nervous system myelin
T5 7252-7265 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 40-58 Disease denotes neurologic disease http://purl.obolibrary.org/obo/MONDO_0005071
T2 139-147 Disease denotes CoViD‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 356-374 Disease denotes neurologic disease http://purl.obolibrary.org/obo/MONDO_0005071
T4 388-409 Disease denotes monoclonal gammopathy http://purl.obolibrary.org/obo/MONDO_0004960
T5 1195-1205 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T6 1357-1365 Disease denotes CoViD‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 1586-1593 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 1856-1863 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T9 2195-2213 Disease denotes neurologic disease http://purl.obolibrary.org/obo/MONDO_0005071
T10 2621-2639 Disease denotes neurologic disease http://purl.obolibrary.org/obo/MONDO_0005071
T11 2985-2993 Disease denotes CoViD‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 3118-3128 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T13 3324-3345 Disease denotes monoclonal gammopathy http://purl.obolibrary.org/obo/MONDO_0004960
T14 4025-4035 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T15 4459-4480 Disease denotes monoclonal gammopathy http://purl.obolibrary.org/obo/MONDO_0004960
T16 6171-6181 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T17 6252-6258 Disease denotes ataxia http://purl.obolibrary.org/obo/MONDO_0000437
T18 6526-6534 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 6589-6599 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T20 6710-6718 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 7612-7620 Disease denotes COViD‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 8185-8203 Disease denotes multiple sclerosis http://purl.obolibrary.org/obo/MONDO_0005301
T23 8323-8343 Disease denotes inflammatory disease http://purl.obolibrary.org/obo/MONDO_0021166
T24 8629-8637 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 8643-8664 Disease denotes monoclonal gammopathy http://purl.obolibrary.org/obo/MONDO_0004960
T26 8972-8979 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 9097-9107 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T28 9141-9149 Disease denotes CoVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1195-1205 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T2 3104-3117 Phenotype denotes demyelinating http://purl.obolibrary.org/obo/HP_0011096
T3 3118-3128 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T4 4025-4035 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T5 4637-4657 Phenotype denotes increased IgM levels http://purl.obolibrary.org/obo/HP_0003496
T6 6171-6181 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T7 6199-6217 Phenotype denotes sensory impairment http://purl.obolibrary.org/obo/HP_0003474
T8 6219-6238 Phenotype denotes disturbance in gait http://purl.obolibrary.org/obo/HP_0001288
T9 6240-6246 Phenotype denotes tremor http://purl.obolibrary.org/obo/HP_0001337
T10 6252-6258 Phenotype denotes ataxia http://purl.obolibrary.org/obo/HP_0001251
T11 6270-6284 Phenotype denotes incoordination http://purl.obolibrary.org/obo/HP_0002311
T12 6295-6307 Phenotype denotes sensory loss http://purl.obolibrary.org/obo/HP_0003474
T13 6589-6599 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T14 8447-8456 Phenotype denotes paralysis http://purl.obolibrary.org/obo/HP_0003470
T15 9097-9107 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1195-1205 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T2 3104-3117 Phenotype denotes demyelinating http://purl.obolibrary.org/obo/HP_0011096
T3 3118-3128 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T4 4025-4035 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T5 4637-4657 Phenotype denotes increased IgM levels http://purl.obolibrary.org/obo/HP_0003496
T6 6171-6181 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T7 6199-6217 Phenotype denotes sensory impairment http://purl.obolibrary.org/obo/HP_0003474
T8 6219-6238 Phenotype denotes disturbance in gait http://purl.obolibrary.org/obo/HP_0001288
T9 6240-6246 Phenotype denotes tremor http://purl.obolibrary.org/obo/HP_0001337
T10 6252-6258 Phenotype denotes ataxia http://purl.obolibrary.org/obo/HP_0001251
T11 6270-6284 Phenotype denotes incoordination http://purl.obolibrary.org/obo/HP_0002311
T12 6295-6307 Phenotype denotes sensory loss http://purl.obolibrary.org/obo/HP_0003474
T13 6589-6599 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T14 8447-8456 Phenotype denotes paralysis http://purl.obolibrary.org/obo/HP_0003470
T15 9097-9107 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T1 1498-1504 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T2 1498-1504 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T3 1769-1784 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T4 2063-2078 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T5 3756-3785 http://purl.obolibrary.org/obo/GO_0022010 denotes central nervous system myelin
T6 7252-7265 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1498-1504 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T2 1498-1504 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T3 1769-1784 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T4 2063-2078 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T5 3756-3785 http://purl.obolibrary.org/obo/GO_0022010 denotes central nervous system myelin
T6 7250-7265 http://purl.obolibrary.org/obo/GO_0006487 denotes N‐glycosylation
T7 7252-7265 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 474-496 GlycoEpitope denotes Human Natural Killer‐1 http://www.glycoepitope.jp/epitopes/EP0001

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes A sugar‐coated strategy to treat a rare neurologic disease provides a blueprint for a decoy glycan therapeutic and a potential vaccine for CoViD‐19
T2 148-316 Sentence denotes An Editorial Highlight for “Selective inhibition of anti‐MAG IgM autoantibody binding to myelin by an antigen specific glycopolymer”on https://doi.org/10.1111/jnc.15021
T3 317-325 Sentence denotes STEINMAN
T4 327-335 Sentence denotes Abstract
T5 336-344 Sentence denotes Abstract
T6 346-609 Sentence denotes In a rare neurologic disease known as IgM monoclonal gammopathy the immune system targets a sulfated trisaccharide known as the Human Natural Killer‐1 (HNK‐1) epitope that comprises a constituent of the myelin sheath known as MAG (myelin‐associated glycoprotein).
T7 610-1061 Sentence denotes This Editorial highlights a study by Aliu and colleagues in the current issue of the Journal of Neurochemistry, in which the investigators constructed a biodegradable poly‐l‐lysine backbone with multiple copies of this sulfated HNK‐1 trisaccharide. This decoy, poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside, known as PPSGG, removed anti‐MAG IgM autoantibodies from the blood, while not activating the immune system.
T8 1062-1206 Sentence denotes These findings provide a path for the selective removal of a pathogenic set of antibodies that target the myelin sheath resulting in neuropathy.
T9 1207-1525 Sentence denotes These findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor‐binding domain of CoViD‐19, which might inhibit viral adhesion to its receptor, the angiotensin‐converting enzyme‐2 (ACE2) protein, thereby impairing cellular uptake of the virus itself.
T10 1526-1690 Sentence denotes The deployment of complex polysaccharides that mimic actual COVID19 polysaccharides on the spike protein may also provide a feasible structural basis for a vaccine.
T11 1691-1806 Sentence denotes Carbohydrate mimics, if conjugated to a carrier or backbone, might provoke an immune response to the spike protein.
T12 1807-2037 Sentence denotes A vaccine that targets critical carbohydrates on COVID19, and then neutralizes the virus would recapitulate a successful strategy employed in other microbial vaccines, like the pneumococcal vaccines and the meningococcal vaccines.
T13 2038-2154 Sentence denotes These vaccines direct an immune response to complex carbohydrates and successfully prevent life‐threatening disease.
T14 2155-2275 Sentence denotes This paper provides lessons from a rare neurologic disease that may teach us strategies applicable to a global pandemic.
T15 2277-2716 Sentence denotes The present Editorial highlights a study by Aliu and colleagues, entitled “Selective inhibition of anti‐MAG IgM autoantibody binding to myelin by an antigen specific glycopolymer” published in the current issue of the Journal of Neurochemistry, in which the authors have developed a therapy directed to a highly specific target to treat a rare neurologic disease where a carbohydrate component of the myelin sheath is attacked by antibody.
T16 2717-2827 Sentence denotes The targeted therapy specifically blocks the antibody from binding to a particular sugar on the myelin sheath.
T17 2828-3084 Sentence denotes The authors' findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor‐binding domain of CoViD‐19, which might inhibit viral adhesion to its receptor and thus lead the way toward vaccines.
T18 3086-3101 Sentence denotes 1 INTRODUCTION
T19 3102-3252 Sentence denotes A demyelinating neuropathy targeting myelin‐associated glycoprotein (MAG) has an incidence of approximately one per 100,000 (Mygland & Monstad, 2001).
T20 3253-3489 Sentence denotes In this disease there is production of an IgM antibody resulting in a “monoclonal gammopathy” targeting a particular carbohydrate known as Cellular Differentiation antigen 57 (CD57) and also known as human natural killer cell‐1 (HNK‐1).
T21 3490-3652 Sentence denotes The HNK‐1 antigen is found on MAG, as well as on natural killer cells, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules (Pernick, 2019).
T22 3653-3786 Sentence denotes CD57 belongs to a family of sialic acid‐binding Ig‐like lectins (siglecs) found on both peripheral and central nervous system myelin.
T23 3787-4036 Sentence denotes In this issue investigators (Aliu et al, 2020) showed that poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside, known as PPSGG, removed anti‐MAG IgM autoantibodies from the blood in a mouse model of this IgM neuropathy.
T24 4037-4192 Sentence denotes In a previous study these investigators developed antigen‐specific molecules with nanomolar inhibitory potency for anti‐MAG IgM (Herrendorff et al., 2017).
T25 4193-4336 Sentence denotes Here the investigators also show that PPSGG blocked the binding of an anti‐MAG IgM from patients to sciatic nerve myelin of non‐human primates.
T26 4337-4422 Sentence denotes They also tested some of the pharmacokinetic and pharmacodynamic properties of PPSGG.
T27 4423-4595 Sentence denotes In patients suffering from this IgM monoclonal gammopathy, non‐specific strategies are used to diminish IgM antibody including targeting of all CD20 B cells with Rituximab.
T28 4596-4747 Sentence denotes On occasion flares of disease occur with increased IgM levels of antibody targeting MAG have followed therapy with Rituximab (Broglio and Luria, 2005).
T29 4748-4857 Sentence denotes The strategy employed with PPSGG is specific to the antigen that triggers the pathogenic IgM in this disease.
T30 4858-4937 Sentence denotes One can refer to such treatment as “antigen‐specific” immunotherapy (Figure 1).
T31 4938-5345 Sentence denotes FIGURE 1 The strategy employed by Aliu et al, provide a basis for a passive immune therapy with a decoy carbohydrate preventing the virus from docking on its receptor, and also provide a foundation for a carbohydrate‐based active immunization when coupled to a suitable carrier Investigations in the mouse model revealed that practical doses of PPSGG were able to sufficiently reduce IgM that binds to MAG.
T32 5346-5472 Sentence denotes Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model.
T33 5473-5622 Sentence denotes Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach.
T34 5623-5763 Sentence denotes In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells.
T35 5764-5829 Sentence denotes In addition, no activation of CD11b dendritic cells was observed.
T36 5830-5948 Sentence denotes These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials.
T37 5949-6041 Sentence denotes Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study.
T38 6042-6326 Sentence denotes Writing about these exquisite approaches to targeting carbohydrates for a potential antigen‐specific therapy for an inflammatory neuropathy characterized by sensory impairment, disturbance in gait, tremor, and ataxia (a form of incoordination following sensory loss) makes one wonder:
T39 6327-6504 Sentence denotes Could such an approach, targeting critical carbohydrates in a disease, have broader applicability to other diseases where complex carbohydrates play a key pathophysiologic role?
T40 6505-6719 Sentence denotes In these days of the COVID‐19 pandemic, the experiments described on monoclonal IgM neuropathy raise the issue that a similar strategy might be deployed to target the carbohydrates in the spike protein of COVID‐19.
T41 6720-6790 Sentence denotes Spike proteins in coronviruses are known to be camouflaged by glycans:
T42 6791-6939 Sentence denotes Mass spectrometry studies revealed in a feline coronavirus that high mannose and complex N‐Glycans accounted for a quarter of the mass of the spike.
T43 6940-7063 Sentence denotes Moreover, the N‐glycans are critical for providing the propeller like conformation of these structures (Yang et al., 2020).
T44 7064-7185 Sentence denotes In the so‐called receptor‐binding domain of the spike protein there are 22 glycan‐binding sites (Shahajan, Supekar et al.
T45 7186-7192 Sentence denotes 2020).
T46 7193-7316 Sentence denotes High mannose, hybrid and complex‐type glycans across the N‐glycosylation sites have been identified with mass spectrometry.
T47 7317-7525 Sentence denotes One could imagine building a therapeutic which might contain the carbohydrates, or a suitable mimic, of the spike protein coupled to a carrier molecule, much in a similar fashion to how PPSGG was constructed.
T48 7526-7677 Sentence denotes Such a “decoy” carbohydrate could block the binding and subsequent internalization of COViD‐19 to its receptor, angiotensin converting enzyme‐2 (ACE2).
T49 7678-7779 Sentence denotes In addition, spike carbohydrate clusters coupled to a carrier might proof to be an effective vaccine.
T50 7780-7912 Sentence denotes Both the pneumococcal vaccine and the meningococcal vaccines target polysaccharides in pneumococcus and meningococcus, respectively.
T51 7913-8033 Sentence denotes They couple the appropriate polysaccharide to a suitable carrier to achieve potent carbohydrate‐specific immunogenicity.
T52 8034-8253 Sentence denotes In a different neuroinflammatory disease antibodies to cryptic mannose containing glycans were observed in the cerebrospinal fluid of individuals with multiple sclerosis, and in its animal model EAE (Wang et al., 2014).
T53 8254-8344 Sentence denotes There again is some precedent for an antigen‐specific therapy for an inflammatory disease.
T54 8345-8496 Sentence denotes Injection of these oligomannose glycans coupled to a protein carrier reduced the clinical severity of paralysis in this animal model (Wang, Bhat et al.
T55 8497-8503 Sentence denotes 2014).
T56 8504-8638 Sentence denotes The success in parlaying the oligomannose glycans in MS and in its EAE model, could be emulated in strategies for therapy of COVID‐19.
T57 8639-8704 Sentence denotes IgM monoclonal gammopathy targeting MAG is indeed a rare disease.
T58 8705-8807 Sentence denotes Lessons from rare diseases often inform us of bold approaches for the treatment of widespread disease.
T59 8808-8986 Sentence denotes The pioneering work of Aliu and colleagues described in this issue, might serve as a guidepost for designing effective therapeutics to the glycan components of the COVID19 virus.
T60 8987-9159 Sentence denotes Such endeavors may produce a sweet ending to a tragedy including both the harsh clinical realities of IgM MAG neuropathy and to the horrors of the deadly CoVID‐19 pandemic.
T61 9161-9182 Sentence denotes CONFLICTS OF INTEREST
T62 9183-9233 Sentence denotes The author has no conflict of interest to declare.
T63 9235-9250 Sentence denotes ACKNOWLEDGMENTS
T64 9251-9298 Sentence denotes This work was supported by NIH 2U01AI101984‐06.
T65 9299-9357 Sentence denotes Editorial advice from Dr Jonathan Steinman is appreciated.
T66 9358-9486 Sentence denotes The figure was re‐drawn in BioRender (https://biorender.com/) by Marco Bazelmans on the basis of a draft provided by the author.

LitCovid-sample-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 474-496 GlycoEpitope denotes Human Natural Killer‐1 http://www.glycoepitope.jp/epitopes/EP0001

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T1 6860-6867 http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname denotes mannose
T2 7198-7205 http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname denotes mannose
T3 8097-8104 http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname denotes mannose

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 86-98 Chemical denotes decoy glycan
4 40-58 Disease denotes neurologic disease MESH:D020271
5 139-147 Disease denotes CoViD‐19 MESH:C000657245
33 498-503 Gene denotes HNK‐1 Gene:27087
34 572-575 Gene denotes MAG Gene:4099
35 577-607 Gene denotes myelin‐associated glycoprotein Gene:4099
36 838-843 Gene denotes HNK‐1 Gene:27087
37 1423-1454 Gene denotes angiotensin‐converting enzyme‐2 Gene:59272
38 1456-1460 Gene denotes ACE2 Gene:59272
39 1617-1622 Gene denotes spike Gene:43740568
40 1792-1797 Gene denotes spike Gene:43740568
41 983-986 Gene denotes MAG Gene:4099
42 447-460 Chemical denotes trisaccharide MESH:D014312
43 777-790 Chemical denotes poly‐l‐lysine
44 844-857 Chemical denotes trisaccharide MESH:D014312
45 871-952 Chemical denotes poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside
46 963-968 Chemical denotes PPSGG
47 1282-1297 Chemical denotes polysaccharides MESH:D011134
48 1552-1567 Chemical denotes polysaccharides MESH:D011134
49 1586-1609 Chemical denotes COVID19 polysaccharides
50 1691-1703 Chemical denotes Carbohydrate MESH:D002241
51 1839-1852 Chemical denotes carbohydrates MESH:D002241
52 2090-2103 Chemical denotes carbohydrates MESH:D002241
53 356-374 Disease denotes neurologic disease MESH:D020271
54 1195-1205 Disease denotes neuropathy MESH:D009422
55 1357-1365 Disease denotes CoViD‐19 MESH:C000657245
56 1856-1863 Disease denotes COVID19 MESH:C000657245
57 1984-1996 Disease denotes pneumococcal MESH:D011008
58 2014-2027 Disease denotes meningococcal MESH:D008589
59 2195-2213 Disease denotes neurologic disease MESH:D020271
66 2381-2384 Gene denotes MAG Gene:4099
67 2648-2660 Chemical denotes carbohydrate MESH:D002241
68 2800-2805 Chemical denotes sugar MESH:D000073893
69 2910-2925 Chemical denotes polysaccharides MESH:D011134
70 2621-2639 Disease denotes neurologic disease MESH:D020271
71 2985-2993 Disease denotes CoViD‐19 MESH:C000657245
82 3139-3169 Gene denotes myelin‐associated glycoprotein Gene:4099
83 3482-3487 Gene denotes HNK‐1 Gene:27087
84 3494-3499 Gene denotes HNK‐1 Gene:27087
85 3171-3174 Gene denotes MAG Gene:4099
86 3520-3523 Gene denotes MAG Gene:4099
87 3453-3458 Species denotes human Tax:9606
88 3370-3382 Chemical denotes carbohydrate MESH:D002241
89 3681-3692 Chemical denotes sialic acid MESH:D019158
90 3104-3128 Disease denotes demyelinating neuropathy MESH:D003711
91 3756-3785 Disease denotes central nervous system myelin MESH:D020278
104 4268-4271 Gene denotes MAG Gene:4099
105 4157-4160 Gene denotes MAG Gene:17136
106 3958-3961 Gene denotes MAG Gene:17136
107 4001-4006 Species denotes mouse Tax:10090
108 4281-4289 Species denotes patients Tax:9606
109 4321-4326 Species denotes human Tax:9606
110 3846-3899 Chemical denotes poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)
111 3900-3927 Chemical denotes (1→3)‐β‐d‐galactopyranoside
112 3938-3943 Chemical denotes PPSGG
113 4231-4236 Chemical denotes PPSGG
114 4416-4421 Chemical denotes PPSGG
115 4021-4035 Disease denotes IgM neuropathy MESH:D053306
121 4680-4683 Gene denotes MAG Gene:4099
122 4426-4434 Species denotes patients Tax:9606
123 4585-4594 Chemical denotes Rituximab MESH:D000069283
124 4711-4720 Chemical denotes Rituximab MESH:D000069283
125 4775-4780 Chemical denotes PPSGG
128 5037-5055 Chemical denotes decoy carbohydrate
129 5143-5155 Chemical denotes carbohydrate MESH:D002241
141 5794-5799 Gene denotes CD11b Gene:3684
142 5972-5975 Gene denotes MAG Gene:4099
143 5751-5754 Gene denotes MAG Gene:4099
144 5429-5432 Gene denotes MAG Gene:17136
145 5341-5344 Gene denotes MAG Gene:17136
146 5239-5244 Species denotes mouse Tax:10090
147 5460-5465 Species denotes mouse Tax:10090
148 5926-5931 Species denotes human Tax:9606
149 5736-5741 Species denotes human Tax:9606
150 5284-5289 Chemical denotes PPSGG
151 5683-5688 Chemical denotes PPSGG
165 6693-6698 Gene denotes spike Gene:43740568
166 6096-6109 Chemical denotes carbohydrates MESH:D002241
167 6370-6383 Chemical denotes carbohydrates MESH:D002241
168 6457-6470 Chemical denotes carbohydrates MESH:D002241
169 6672-6685 Chemical denotes carbohydrates MESH:D002241
170 6171-6181 Disease denotes neuropathy MESH:D009422
171 6199-6217 Disease denotes sensory impairment MESH:D012678
172 6240-6246 Disease denotes tremor MESH:D014202
173 6252-6258 Disease denotes ataxia MESH:D001259
174 6270-6284 Disease denotes incoordination MESH:D001259
175 6526-6534 Disease denotes COVID‐19 MESH:C000657245
176 6585-6599 Disease denotes IgM neuropathy MESH:D053306
177 6710-6718 Disease denotes COVID‐19 MESH:C000657245
185 6720-6725 Gene denotes Spike Gene:43740568
186 6933-6938 Gene denotes spike Gene:43740568
187 6831-6849 Species denotes feline coronavirus Tax:12663
188 6782-6789 Chemical denotes glycans MESH:D011134
189 6860-6867 Chemical denotes mannose MESH:D008358
190 6880-6889 Chemical denotes N‐Glycans
191 6954-6963 Chemical denotes N‐glycans
212 7112-7117 Gene denotes spike Gene:43740568
213 7425-7430 Gene denotes spike Gene:43740568
214 7638-7669 Gene denotes angiotensin converting enzyme‐2 Gene:59272
215 7671-7675 Gene denotes ACE2 Gene:59272
216 7691-7696 Gene denotes spike Gene:43740568
217 7139-7145 Chemical denotes glycan MESH:D011134
218 7198-7205 Chemical denotes mannose MESH:D008358
219 7231-7238 Chemical denotes glycans MESH:D011134
220 7250-7251 Chemical denotes N MESH:D009584
221 7382-7395 Chemical denotes carbohydrates MESH:D002241
222 7503-7508 Chemical denotes PPSGG
223 7534-7553 Chemical denotes decoy” carbohydrate
224 7697-7709 Chemical denotes carbohydrate MESH:D002241
225 7848-7863 Chemical denotes polysaccharides MESH:D011134
226 7941-7955 Chemical denotes polysaccharide MESH:D011134
227 7996-8008 Chemical denotes carbohydrate MESH:D002241
228 7612-7620 Disease denotes COViD‐19 MESH:C000657245
229 7789-7801 Disease denotes pneumococcal MESH:D011008
230 7818-7831 Disease denotes meningococcal MESH:D008589
231 7867-7897 Disease denotes pneumococcus and meningococcus
241 8089-8096 Gene denotes cryptic Gene:55997
242 8097-8104 Chemical denotes mannose MESH:D008358
243 8116-8123 Chemical denotes glycans MESH:D011134
244 8364-8384 Chemical denotes oligomannose glycans
245 8533-8553 Chemical denotes oligomannose glycans
246 8049-8074 Disease denotes neuroinflammatory disease MESH:D003141
247 8185-8203 Disease denotes multiple sclerosis MESH:D009103
248 8447-8456 Disease denotes paralysis MESH:D010243
249 8629-8637 Disease denotes COVID‐19 MESH:C000657245
256 8675-8678 Gene denotes MAG Gene:4099
257 8972-8985 Species denotes COVID19 virus Tax:2697049
258 8831-8835 Chemical denotes Aliu
259 8947-8953 Chemical denotes glycan MESH:D011134
260 9089-9107 Disease denotes IgM MAG neuropathy MESH:D053306
261 9141-9149 Disease denotes CoVID‐19 MESH:C000657245