FirstAuthors:14898 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/FirstAuthors/sourceid/14898","sourcedb":"FirstAuthors","sourceid":"14898","text":"〈タイトル〉Hippoシグナル伝達系はがん細胞において宿主の腫瘍免疫を抑制する\r\n\r\n〈著 者〉諸石 寿朗\r\n〈著者所属〉米国California大学San Diego校Department of Pharmacology\r\n〈著者email〉tmoroishi@ucsd.edu（諸石寿朗）\r\n\r\n〈対象論文〉\r\nThe Hippo pathway kinases LATS1/2 suppress cancer immunity.\r\nToshiro Moroishi, Tomoko Hayashi, Wei-Wei Pan, Yu Fujita, Matthew V. Holt, Jun Qin, Dennis A. Carson, Kun-Liang Guan\r\nCell, 167, 1525-1539.e17 (2016)\r\n\r\n〈要 約〉\r\n　近年，Hippoシグナル伝達系は正常な細胞のがん化をふせぐシグナル伝達系として注目されているが，筆者らは，がん細胞においてHippoシグナル伝達系は宿主の腫瘍免疫を抑制することを発見した．Hippoシグナル伝達経路の中心となるキナーゼであるLATS1およびLATS2をがん細胞において欠損させると，宿主の腫瘍に対する免疫応答が増強されて腫瘍の増殖が強力に抑制された．さらに，LATS1およびLATS2を欠損させることによりがん細胞の免疫原性が向上し，がんに対するワクチンとしての効果が飛躍的に増強された．これらの結果から，Hippoシグナル伝達系は腫瘍に対する免疫原性を制御すること，また，LATS1およびLATS2はがん免疫療法において創薬の新たな標的になりうることが示唆された．\r\n\r\nはじめに\r\n　悪性腫瘍は細胞の形質転換，腫瘍の増大，転移といったいくつもの過程において細胞のシグナル伝達系を多様に変化させ，がん細胞と宿主の相互作用のなかで進行する．近年，Hippoシグナル伝達系はこれらのがん細胞の特性を制御するシグナル伝達系として注目されてきた1)．また，Hippoシグナル伝達系はがんの生物学にとどまらず，臓器の発生や大きさの制御，組織の再生，また，幹細胞の生物学においても重要な役割を担っている2)．\r\n　Hippoシグナル伝達経路の中心はMST1およびMST2，MAP4Kファミリーキナーゼ（MAP4K1〜MAP4K7），LATS1およびLATS2を含むキナーゼカスケードから構成される3)．Hippoシグナルがオンになると，上流のキナーゼであるMST1およびMST2またはMAP4Kファミリーキナーゼが下流のキナーゼであるLATS1およびLATS2をリン酸化し活性化する4)．活性化したLATS1およびLATS2はHippoシグナル伝達系において転写を制御する機能を担う転写因子YAPおよびTAZをリン酸化し，このリン酸化によりYAPおよびTAZは細胞質に局在し転写因子としては不活性化される．逆に，LATS1およびLATS2が不活性化した（Hippoシグナルがオフになった）場合には，YAPおよびTAZは脱リン酸化されて核に局在し転写因子として活性化する．すなわち，Hippoシグナル伝達系のおもな役割はLATS1およびLATS2の活性化と，それによる転写因子YAPおよびTAZの不活性化である．\r\n　これまでの研究において，Hippoシグナル伝達系は正常な細胞のがん化をふせぐシグナル伝達系として注目されてきた．たとえば，マウスの肝臓における上流のキナーゼMST1およびMST2の欠損，あるいは，下流の転写因子YAPの過剰な発現は，ともに肝臓がんの発がんを促進する5)．これらの研究は，発がんを抑制するシグナル伝達系としてのHippoシグナル伝達系の役割を確立させた．しかしながら，腫瘍は複雑な過程をへてがん細胞と宿主との相互作用のなかで悪性腫瘍へと進行する．これまでの研究においては，Hippoシグナル伝達系のがんの進行の過程，とくに，がん細胞と宿主の腫瘍に対する免疫応答との相互作用における役割は明らかにされていなかった．\r\n\r\n1．LATS1およびLATS2を欠損したがん細胞はin vitroにおいて足場に依存しない増殖が増強する\r\n　腫瘍免疫におけるHippoシグナル伝達系の役割について調べるため，同系マウスモデルを用いて3つの異なるがん種をそれぞれ3つの異なる遺伝的な背景をもつマウスに移植し腫瘍の増殖能を調べた．これらのがん細胞におけるHippoシグナル伝達系の応答について調べたところ，血清飢餓やストレスシグナルなどHippoシグナル伝達系に影響をおよぼす生理的な刺激に応じてYAPおよびTAZのリン酸化および細胞における局在が制御された．すなわち，これらのがん細胞においてHippoシグナル伝達系は正常に機能しており，これらの細胞のがんとしての特性はHippoシグナル伝達系のほかの変異によりもたらされると考えられた．\r\n　これらのがん細胞においてHippoシグナル伝達系を破綻させるため，CRISPR-Cas9系を利用した遺伝子編集技術を用いてLATS1およびLATS2を同時に欠損したがん細胞を作出した．すると，野生型のがん細胞においては生理的な刺激に応じてYAPおよびTAZのリン酸化および細胞における局在が制御されたのに対し，LATS1およびLATS2を欠損したがん細胞においてはYAPおよびTAZがつねに脱リン酸化して核に局在し恒常的に活性化した．これらのがん細胞のがんとしての性質を調べるため，in vitroにおける足場に依存しない増殖能について調べた．YAPおよびTAZによる転写の活性化は基本的に細胞の増殖を正に制御する方向にはたらくことが知られている．この知見と合致して，LATS1およびLATS2を欠損したがん細胞においてはがん細胞の足場に依存しない増殖能が増強された．以上の結果から，がん細胞におけるLATS1およびLATS2の欠損はYAPおよびTAZを恒常的に活性化させ，がん細胞のもつ足場に依存しない増殖能をさらに増強させることがわかった．\r\n\r\n2．LATS1およびLATS2を欠損したがん細胞はin vivoにおける腫瘍の増殖が強力に抑制される\r\n　野生型のがん細胞とLATS1およびLATS2を欠損したがん細胞をそれぞれ対応する遺伝的な背景をもつマウスに移植し腫瘍の増殖能について調べた．すると，すべてのがんモデルにおいて，LATS1およびLATS2の欠損はin vivoにおけるがん細胞の増殖を強力に抑制した．とくに，SCC7頭頸部扁平上皮がんモデルにおいては，野生型のSCC7細胞を移植したすべてのマウスは腫瘍を形成し，移植ののち20日ほどで死亡したのに対し，LATS1およびLATS2を欠損したSCC7細胞を移植したすべてのマウスはがん細胞を完全に拒絶し生存した．すなわち，LATS1およびLATS2の欠損はがん細胞の足場に依存しない増殖能を増強するにもかかわらず，生体における腫瘍の形成能を強力に抑制することが明らかにされた．これまで，Hippoシグナル伝達系はがんを抑制するシグナル伝達系と考えられていたため，これらの実験の結果はまったく予想外であった．\r\n\r\n3．がん細胞におけるLATS1およびLATS2の欠損は宿主の腫瘍に対する免疫応答を増強する\r\n　がん細胞におけるLATS1およびLATS2の欠損ががん細胞の増殖に対しin vitroとin vivoとでまったく逆の効果をもたらしたため，宿主のもつ要因がこのいっけん矛盾するようにみえる実験の結果に関与するのではないかと考えた．実際に，移植したがん細胞の組織切片を調べたところ，LATS1およびLATS2を欠損したがん細胞には多くの免疫細胞が浸潤していた．そこで，宿主の腫瘍に対する免疫応答をB16悪性黒色腫モデルにおいて調べたところ，LATS1およびLATS2を欠損したがん細胞を移植したマウスにおいては体液性免疫および細胞性免疫がともに増強されていた．さらに，獲得免疫系に異常のあるRAG-1ノックアウトマウスを宿主として，野生型のB16細胞あるいはLATS1およびLATS2を欠損するB16細胞を移植したところ，LATS1およびLATS2を欠損したB16細胞は野生型のB16細胞と同様に腫瘍を形成しすべてのマウスが死亡した．これらの結果から，がん細胞におけるLATS1およびLATS2の欠損が宿主の獲得免疫系を増強し，それによりがん細胞を破壊することが示唆された．そこで，LATS1およびLATS2を欠損したB16細胞を放射線を照射したうえでワクチンとしてマウスに投与し，そののち，獲得免疫系の成立をまってこのマウスに野生型のB16細胞を移植したところ，ワクチンを投与したマウスにおいては野生型のB16細胞からの腫瘍の形成が強力に抑制された．以上の結果から，がん細胞におけるLATS1およびLATS2の欠損は腫瘍の免疫原性を向上させ，宿主の獲得免疫系を増強しがん細胞を破壊することが明らかにされた．\r\n\r\n4．LATS1およびLATS2を欠損したがん細胞は宿主の核酸感知系を刺激し腫瘍免疫を惹起する\r\n　LATS1およびLATS2の欠損はYAPおよびTAZを恒常的に活性化させるため，YAPあるいはTAZの過剰な発現により同様の現象が観察されるかどうか調べた．その結果，活性型YAPあるいは活性型TAZを過剰に発現したB16細胞においても，LATS1およびLATS2を欠損したB16細胞と同様に，in vivoにおける腫瘍の形成能が抑制された．がん細胞におけるLATS1およびLATS2の欠損が宿主の腫瘍免疫を刺激する機構について調べるため，獲得免疫系の成立に重要な抗原の提示の過程をin vitroの実験系において精査したところ，LATS1およびLATS2を欠損したがん細胞が細胞外に分泌する小胞により抗原提示細胞である樹状細胞が活性化されることがつきとめられた．さらに，プロテオミクス解析により，LATS1およびLATS2を欠損したがん細胞の分泌する小胞には核酸が多く含まれることが示唆された．核酸には免疫応答を刺激する作用のあることが知られており6)，これらの結果から，LATS1およびLATS2を欠損したがん細胞は核酸を多く含む小胞を分泌することにより宿主の腫瘍に対する免疫応答を惹起するのではないかと仮説をたてた．\r\n　この仮説を検証するため，宿主の核酸感知系において必須な一連のタンパク質のノックアウトマウスを用い，宿主の核酸感知系の異常がLATS1およびLATS2を欠損したがん細胞の増殖におよぼす影響について調べた．その結果，エンドソームを介したToll様受容体-インターフェロン経路がはたらかないマウスにおいて，LATS1およびLATS2の欠損による腫瘍の抑制の効果が障害された．これらの結果から，LATS1およびLATS2を欠損したがん細胞は，核酸を多く含む小胞を分泌することにより宿主の核酸感知系を刺激し，Toll様受容体-インターフェロン経路を活性化することにより腫瘍免疫を増強することが明らかにされた（図1）．\r\n\r\nおわりに\r\n　これまで，Hippoシグナル伝達系は正常な細胞のがん化をふせぐ，がんを抑制するシグナル伝達系と考えられてきた．しかしながら，この研究においては，がん細胞においてHippoシグナル伝達系を障害することにより腫瘍の増殖が抑制されることが明らかにされた．この結果は，いっけんするとHippoシグナル伝達系ががんを抑制するシグナル伝達系とされてきたことと矛盾するように思える．\r\n　筆者らは，Hippoシグナル伝達系は細胞の増殖を負に制御することにより正常な細胞のがん化をふせぐと同時に細胞の免疫原性を抑制することを提唱する．これらの2つのHippoシグナル伝達系の特性は，組織における恒常性の維持に必要と考える（図2）．たとえば，正常な組織においてはHippoシグナル伝達系がYAPおよびTAZの過剰な活性化を抑制し恒常性が維持されているが，組織が損傷したのちの再生の過程など細胞の増殖が必要な状況においては，Hippoシグナル伝達系をオフにしYAPおよびTAZを活性化する必要がある．筆者らは，過去の研究において，YAPおよびTAZの活性化は細胞に自立的にHippoシグナル伝達系の負のフィードバック機構を惹起することを明らかにした7)．そのため，YAPおよびTAZの活性化は一過性であり，損傷の治癒が完了すると再度Hippoシグナル伝達系が機能し組織において恒常性が維持される．しかしながら，LATS1およびLATS2の欠損などにより細胞に自立的なHippoシグナル伝達系の負のフィードバック機構がはたらかなくなると，YAPおよびTAZが恒常的に活性化するため細胞の増殖が異常に亢進しがん化してしまう．しかしながら，この場合も，免疫系がHippoシグナル伝達系の障害を感知し腫瘍免疫を増強することにより，細胞に非自立的な機構によりがん細胞を排除することが可能になる．したがって，Hippoシグナル伝達系による細胞の増殖と免疫原性の抑制は，組織において恒常性を維持するというHippoシグナル伝達系の生理的な役割と矛盾しない．\r\n　近年，がん治療の新しい選択肢としてがん免疫療法が脚光をあびており，いくつかの免疫チェックポイント阻害剤は実際のがん患者を対象としてめざましい成績をあげている8)．しかしながら，個々の患者におけるがん免疫療法への応答性はさまざまで，がんの免疫原性をいかに向上させるかが今後の課題のひとつとなっている．この研究において，がん細胞においてLATS1およびLATS2を欠損させるとがん細胞の免疫原性が向上し，宿主の腫瘍免疫が増強されることによりがん細胞が破壊されることが明らかにされた．そこで，がん細胞においてLATS1およびLATS2を阻害する薬剤を開発することが，がん免疫療法の新たな治療の戦略になることが期待される．注目すべきことに，がんを抑制するシグナル伝達系としての重要性を示唆する多くの結果にもかかわらず，ヒトのがんにおいてHippoシグナル伝達系の遺伝子の変異は非常にまれである1,5)．したがって，LATS1およびLATS2の阻害剤を用いたがん免疫療法はヒトの多くのがん種に応用が可能であると考えられる．しかしながら，マウスとヒトの免疫系は多くの点で異なっており，今回の発見をいかにヒトに応用していくかが今後の課題である．\r\n\r\n〈文 献〉\r\n 1) Moroishi, T., Hansen, C. G. \u0026 Guan, K. L.: The emerging roles of YAP and TAZ in cancer. Nat. Rev. Cancer, 15, 73-79 (2015)\r\n 2) Hansen, C. G., Moroishi, T. \u0026 Guan, K. L.: YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol., 25, 499-513 (2015)\r\n 3) Meng, Z., Moroishi, T. \u0026 Guan, K. L.: Mechanisms of Hippo pathway regulation. Genes Dev., 30, 1-17 (2016)\r\n 4) Meng, Z., Moroishi, T., Mottier-Pavie, V. et al.: MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat. Commun., 6, 8357 (2015)\r\n 5) Harvey, K. F., Zhang, X. \u0026 Thomas, D. M.: The Hippo pathway and human cancer. Nat. Rev. Cancer, 13, 246-257 (2013)\r\n 6) Junt, T. \u0026 Barchet, W.: Translating nucleic acid-sensing pathways into therapies. Nat. Rev. Immunol., 15, 529-544 (2015)\r\n 7) Moroishi, T., Park, H. W., Qin, B. et al.: A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev., 29, 1271-1284 (2015)\r\n 8) Sharma, P. \u0026 Allison, J. P.: Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell, 161, 205-214 (2015)\r\n\r\n〈著者プロフィール〉\r\n諸石 寿朗（Toshiro Moroishi）\r\n略歴：2012年 九州大学大学院医学系学府博士課程 修了，同年 九州大学生体防御医学研究所 学術研究員を経て，2013年より米国California大学San Diego校 博士研究員．\r\n研究テーマ：Hippoシグナル伝達系の全貌の解明と腫瘍免疫．\r\n関心事：ドラックディスカバリー．\r\n\r\n〈図説明〉\r\n図1　がん細胞におけるHippoシグナル伝達系による腫瘍免疫の制御\r\n免疫原性の低いがん細胞は宿主の免疫系による監視を巧妙にすりぬけ増殖する．しかしながら，がん細胞においてLATS1およびLATS2を欠損させてHippoシグナル伝達系を障害すると，がん細胞が核酸を多く含む小胞を細胞外に分泌するようになり，これが宿主の核酸感知系を刺激し，Toll様受容体-インターフェロン経路が活性化される．これによりI型インターフェロンが分泌され，がん抗原提示やT細胞の活性化を含めた宿主の腫瘍に対する免疫応答を惹起する．\r\n図2　Hippoシグナル伝達系による組織における恒常性の維持の機構に関する仮説\r\nHippoシグナル伝達系はYAPおよびTAZを抑制することにより細胞の増殖を負に制御するとともに，細胞の免疫原性を抑制する．Hippoシグナル伝達系の負のフィードバック機構は組織において細胞に自立的に恒常性を維持する．一方で，LATS1およびLATS2の欠損などにより負のフィードバック機構がはたらかなくなり細胞ががん化した場合においても，免疫系がHippoシグナル伝達系の障害を感知し腫瘍免疫を惹起することにより，細胞に非自立的な機構によりがん細胞を排除することが可能になる．したがって，Hippoシグナル伝達系による細胞の増殖と免疫原性の抑制は，ともに組織における恒常性の維持に必須の役割を担う．\r\n","tracks":[{"project":"FA_Top107-forWeb","denotations":[{"id":"T1","span":{"begin":683,"end":688},"obj":"LATS2"},{"id":"T2","span":{"begin":508,"end":513},"obj":"LATS2"},{"id":"T3","span":{"begin":575,"end":580},"obj":"LATS2"},{"id":"T4","span":{"begin":1007,"end":1012},"obj":"LATS2"},{"id":"T5","span":{"begin":1108,"end":1113},"obj":"LATS2"},{"id":"T6","span":{"begin":1140,"end":1145},"obj":"LATS2"},{"id":"T7","span":{"begin":1247,"end":1252},"obj":"LATS2"},{"id":"T8","span":{"begin":1350,"end":1355},"obj":"LATS2"},{"id":"T9","span":{"begin":1718,"end":1723},"obj":"LATS2"},{"id":"T10","span":{"begin":2132,"end":2137},"obj":"LATS2"},{"id":"T11","span":{"begin":2226,"end":2231},"obj":"LATS2"},{"id":"T12","span":{"begin":2405,"end":2410},"obj":"LATS2"},{"id":"T13","span":{"begin":2471,"end":2476},"obj":"LATS2"},{"id":"T14","span":{"begin":2549,"end":2554},"obj":"LATS2"},{"id":"T15","span":{"begin":2609,"end":2614},"obj":"LATS2"},{"id":"T16","span":{"begin":2688,"end":2693},"obj":"LATS2"},{"id":"T17","span":{"begin":2808,"end":2813},"obj":"LATS2"},{"id":"T18","span":{"begin":2866,"end":2871},"obj":"LATS2"},{"id":"T19","span":{"begin":3022,"end":3027},"obj":"LATS2"},{"id":"T20","span":{"begin":3068,"end":3073},"obj":"LATS2"},{"id":"T21","span":{"begin":3200,"end":3205},"obj":"LATS2"},{"id":"T22","span":{"begin":3279,"end":3284},"obj":"LATS2"},{"id":"T23","span":{"begin":3388,"end":3393},"obj":"LATS2"},{"id":"T24","span":{"begin":3420,"end":3425},"obj":"LATS2"},{"id":"T25","span":{"begin":3493,"end":3498},"obj":"LATS2"},{"id":"T26","span":{"begin":3550,"end":3555},"obj":"LATS2"},{"id":"T27","span":{"begin":3701,"end":3706},"obj":"LATS2"},{"id":"T28","span":{"begin":3769,"end":3774},"obj":"LATS2"},{"id":"T29","span":{"begin":3816,"end":3821},"obj":"LATS2"},{"id":"T30","span":{"begin":3934,"end":3939},"obj":"LATS2"},{"id":"T31","span":{"begin":3994,"end":3999},"obj":"LATS2"},{"id":"T32","span":{"begin":4080,"end":4085},"obj":"LATS2"},{"id":"T33","span":{"begin":4164,"end":4169},"obj":"LATS2"},{"id":"T34","span":{"begin":4252,"end":4257},"obj":"LATS2"},{"id":"T35","span":{"begin":4390,"end":4395},"obj":"LATS2"},{"id":"T36","span":{"begin":4479,"end":4484},"obj":"LATS2"},{"id":"T37","span":{"begin":4522,"end":4527},"obj":"LATS2"},{"id":"T38","span":{"begin":5238,"end":5243},"obj":"LATS2"},{"id":"T39","span":{"begin":5673,"end":5678},"obj":"LATS2"},{"id":"T40","span":{"begin":5758,"end":5763},"obj":"LATS2"},{"id":"T41","span":{"begin":5910,"end":5915},"obj":"LATS2"},{"id":"T42","span":{"begin":7426,"end":7431},"obj":"LATS2"},{"id":"T43","span":{"begin":7750,"end":7755},"obj":"LATS2"},{"id":"T44","span":{"begin":7418,"end":7423},"obj":"LATS1"},{"id":"T45","span":{"begin":184,"end":189},"obj":"LATS1"},{"id":"T46","span":{"begin":500,"end":505},"obj":"LATS1"},{"id":"T47","span":{"begin":567,"end":572},"obj":"LATS1"},{"id":"T48","span":{"begin":675,"end":680},"obj":"LATS1"},{"id":"T49","span":{"begin":999,"end":1004},"obj":"LATS1"},{"id":"T50","span":{"begin":1100,"end":1105},"obj":"LATS1"},{"id":"T51","span":{"begin":1132,"end":1137},"obj":"LATS1"},{"id":"T52","span":{"begin":1239,"end":1244},"obj":"LATS1"},{"id":"T53","span":{"begin":1342,"end":1347},"obj":"LATS1"},{"id":"T54","span":{"begin":1710,"end":1715},"obj":"LATS1"},{"id":"T55","span":{"begin":2124,"end":2129},"obj":"LATS1"},{"id":"T56","span":{"begin":2218,"end":2223},"obj":"LATS1"},{"id":"T57","span":{"begin":2397,"end":2402},"obj":"LATS1"},{"id":"T58","span":{"begin":2463,"end":2468},"obj":"LATS1"},{"id":"T59","span":{"begin":2541,"end":2546},"obj":"LATS1"},{"id":"T60","span":{"begin":2601,"end":2606},"obj":"LATS1"},{"id":"T61","span":{"begin":2680,"end":2685},"obj":"LATS1"},{"id":"T62","span":{"begin":2800,"end":2805},"obj":"LATS1"},{"id":"T63","span":{"begin":2858,"end":2863},"obj":"LATS1"},{"id":"T64","span":{"begin":3014,"end":3019},"obj":"LATS1"},{"id":"T65","span":{"begin":3060,"end":3065},"obj":"LATS1"},{"id":"T66","span":{"begin":3192,"end":3197},"obj":"LATS1"},{"id":"T67","span":{"begin":3271,"end":3276},"obj":"LATS1"},{"id":"T68","span":{"begin":3380,"end":3385},"obj":"LATS1"},{"id":"T69","span":{"begin":3412,"end":3417},"obj":"LATS1"},{"id":"T70","span":{"begin":3485,"end":3490},"obj":"LATS1"},{"id":"T71","span":{"begin":3542,"end":3547},"obj":"LATS1"},{"id":"T72","span":{"begin":3693,"end":3698},"obj":"LATS1"},{"id":"T73","span":{"begin":3761,"end":3766},"obj":"LATS1"},{"id":"T74","span":{"begin":3808,"end":3813},"obj":"LATS1"},{"id":"T75","span":{"begin":3926,"end":3931},"obj":"LATS1"},{"id":"T76","span":{"begin":3986,"end":3991},"obj":"LATS1"},{"id":"T77","span":{"begin":4072,"end":4077},"obj":"LATS1"},{"id":"T78","span":{"begin":4156,"end":4161},"obj":"LATS1"},{"id":"T79","span":{"begin":4244,"end":4249},"obj":"LATS1"},{"id":"T80","span":{"begin":4382,"end":4387},"obj":"LATS1"},{"id":"T81","span":{"begin":4471,"end":4476},"obj":"LATS1"},{"id":"T82","span":{"begin":4514,"end":4519},"obj":"LATS1"},{"id":"T83","span":{"begin":5230,"end":5235},"obj":"LATS1"},{"id":"T84","span":{"begin":5665,"end":5670},"obj":"LATS1"},{"id":"T85","span":{"begin":5750,"end":5755},"obj":"LATS1"},{"id":"T86","span":{"begin":5902,"end":5907},"obj":"LATS1"},{"id":"T88","span":{"begin":7742,"end":7747},"obj":"LATS1"},{"id":"T89","span":{"begin":7501,"end":7509},"obj":"Toll-like receptor"},{"id":"T90","span":{"begin":4437,"end":4445},"obj":"Toll-like receptor"},{"id":"T91","span":{"begin":4570,"end":4578},"obj":"Toll-like receptor"},{"id":"T92","span":{"begin":4579,"end":4587},"obj":"interferon"},{"id":"T93","span":{"begin":4446,"end":4454},"obj":"interferon"},{"id":"T94","span":{"begin":7510,"end":7518},"obj":"interferon"},{"id":"T95","span":{"begin":7535,"end":7543},"obj":"interferon"},{"id":"T99","span":{"begin":189,"end":191},"obj":"LATS2"},{"id":"T100","span":{"begin":957,"end":961},"obj":"MST1"},{"id":"T101","span":{"begin":1061,"end":1065},"obj":"MST1"},{"id":"T102","span":{"begin":1469,"end":1473},"obj":"MST1"},{"id":"T104","span":{"begin":964,"end":968},"obj":"MST2"},{"id":"T105","span":{"begin":1068,"end":1072},"obj":"MST2"},{"id":"T106","span":{"begin":1476,"end":1480},"obj":"MST2"},{"id":"T107","span":{"begin":984,"end":990},"obj":"MAP4K1"},{"id":"T108","span":{"begin":991,"end":997},"obj":"MAP4K7"},{"id":"T109","span":{"begin":969,"end":974},"obj":"MAP4K"},{"id":"T112","span":{"begin":1075,"end":1080},"obj":"MAP4K"},{"id":"T113","span":{"begin":1203,"end":1206},"obj":"YAP"},{"id":"T114","span":{"begin":1178,"end":1181},"obj":"YAP"},{"id":"T115","span":{"begin":1282,"end":1285},"obj":"YAP"},{"id":"T116","span":{"begin":1370,"end":1373},"obj":"YAP"},{"id":"T117","span":{"begin":1496,"end":1499},"obj":"YAP"},{"id":"T118","span":{"begin":1938,"end":1941},"obj":"YAP"},{"id":"T119","span":{"begin":2182,"end":2185},"obj":"YAP"},{"id":"T120","span":{"begin":2245,"end":2248},"obj":"YAP"},{"id":"T121","span":{"begin":2335,"end":2338},"obj":"YAP"},{"id":"T122","span":{"begin":2480,"end":2483},"obj":"YAP"},{"id":"T123","span":{"begin":3825,"end":3828},"obj":"YAP"},{"id":"T124","span":{"begin":3848,"end":3851},"obj":"YAP"},{"id":"T125","span":{"begin":3894,"end":3897},"obj":"YAP"},{"id":"T126","span":{"begin":4970,"end":4973},"obj":"YAP"},{"id":"T127","span":{"begin":5054,"end":5057},"obj":"YAP"},{"id":"T128","span":{"begin":5090,"end":5093},"obj":"YAP"},{"id":"T129","span":{"begin":5157,"end":5160},"obj":"YAP"},{"id":"T130","span":{"begin":5293,"end":5296},"obj":"YAP"},{"id":"T134","span":{"begin":7642,"end":7645},"obj":"YAP"},{"id":"T135","span":{"begin":7648,"end":7651},"obj":"TAZ"},{"id":"T136","span":{"begin":1184,"end":1187},"obj":"TAZ"},{"id":"T137","span":{"begin":1209,"end":1212},"obj":"TAZ"},{"id":"T138","span":{"begin":1288,"end":1291},"obj":"TAZ"},{"id":"T139","span":{"begin":1376,"end":1379},"obj":"TAZ"},{"id":"T140","span":{"begin":1944,"end":1947},"obj":"TAZ"},{"id":"T141","span":{"begin":2188,"end":2191},"obj":"TAZ"},{"id":"T142","span":{"begin":2251,"end":2254},"obj":"TAZ"},{"id":"T143","span":{"begin":2341,"end":2344},"obj":"TAZ"},{"id":"T144","span":{"begin":2486,"end":2489},"obj":"TAZ"},{"id":"T145","span":{"begin":3831,"end":3834},"obj":"TAZ"},{"id":"T146","span":{"begin":3855,"end":3858},"obj":"TAZ"},{"id":"T147","span":{"begin":3904,"end":3907},"obj":"TAZ"},{"id":"T148","span":{"begin":4976,"end":4979},"obj":"TAZ"},{"id":"T149","span":{"begin":5060,"end":5063},"obj":"TAZ"},{"id":"T150","span":{"begin":5096,"end":5099},"obj":"TAZ"},{"id":"T151","span":{"begin":5163,"end":5166},"obj":"TAZ"},{"id":"T152","span":{"begin":5299,"end":5302},"obj":"TAZ"},{"id":"T153","span":{"begin":3346,"end":3351},"obj":"RAG-1"}],"attributes":[{"id":"A132","pred":"Main_UniprotID","subj":"T147","obj":"Q9EPK5"},{"id":"A84","pred":"Main_UniprotID","subj":"T84","obj":"Q8BYR2"},{"id":"A21","pred":"Main_UniprotID","subj":"T21","obj":"Q7TSJ6"},{"id":"A97","pred":"Main_UniprotID","subj":"T107","obj":"Q92918"},{"id":"A107","pred":"Main_UniprotID","subj":"T122","obj":"P46938"},{"id":"A22","pred":"Main_UniprotID","subj":"T22","obj":"Q7TSJ6"},{"id":"A86","pred":"Main_UniprotID","subj":"T86","obj":"Q8BYR2"},{"id":"A126","pred":"Main_UniprotID","subj":"T141","obj":"Q9EPK5"},{"id":"A1","pred":"Main_UniprotID","subj":"T1","obj":"Q7TSJ6"},{"id":"A2","pred":"Main_UniprotID","subj":"T2","obj":"Q7TSJ6"},{"id":"A8","pred":"Main_UniprotID","subj":"T8","obj":"Q7TSJ6"},{"id":"A73","pred":"Main_UniprotID","subj":"T73","obj":"Q8BYR2"},{"id":"A74","pred":"Main_UniprotID","subj":"T74","obj":"Q8BYR2"},{"id":"A112","pred":"Main_UniprotID","subj":"T127","obj":"P46938"},{"id":"A10","pred":"Main_UniprotID","subj":"T10","obj":"Q7TSJ6"},{"id":"A124","pred":"Main_UniprotID","subj":"T139","obj":"Q9EPK5"},{"id":"A52","pred":"Main_UniprotID","subj":"T52","obj":"Q8BYR2"},{"id":"A65","pred":"Main_UniprotID","subj":"T65","obj":"Q8BYR2"},{"id":"A81","pred":"Main_UniprotID","subj":"T81","obj":"Q8BYR2"},{"id":"A127","pred":"Main_UniprotID","subj":"T142","obj":"Q9EPK5"},{"id":"A51","pred":"Main_UniprotID","subj":"T51","obj":"Q8BYR2"},{"id":"A57","pred":"Main_UniprotID","subj":"T57","obj":"Q8BYR2"},{"id":"A92","pred":"Main_UniprotID","subj":"T102","obj":"Q13043"},{"id":"A46","pred":"Main_UniprotID","subj":"T46","obj":"Q8BYR2"},{"id":"A68","pred":"Main_UniprotID","subj":"T68","obj":"Q8BYR2"},{"id":"A77","pred":"Main_UniprotID","subj":"T77","obj":"Q8BYR2"},{"id":"A15","pred":"Main_UniprotID","subj":"T15","obj":"Q7TSJ6"},{"id":"A33","pred":"Main_UniprotID","subj":"T33","obj":"Q7TSJ6"},{"id":"A110","pred":"Main_UniprotID","subj":"T125","obj":"P46938"},{"id":"A12","pred":"Main_UniprotID","subj":"T12","obj":"Q7TSJ6"},{"id":"A34","pred":"Main_UniprotID","subj":"T34","obj":"Q7TSJ6"},{"id":"A39","pred":"Main_UniprotID","subj":"T39","obj":"Q7TSJ6"},{"id":"A62","pred":"Main_UniprotID","subj":"T62","obj":"Q8BYR2"},{"id":"A102","pred":"Main_UniprotID","subj":"T117","obj":"P46938"},{"id":"A58","pred":"Main_UniprotID","subj":"T58","obj":"Q8BYR2"},{"id":"A120","pred":"Main_UniprotID","subj":"T135","obj":"Q9EPK5"},{"id":"A16","pred":"Main_UniprotID","subj":"T16","obj":"Q7TSJ6"},{"id":"A88","pred":"Main_UniprotID","subj":"T88","obj":"Q8BYR2"},{"id":"A66","pred":"Main_UniprotID","subj":"T66","obj":"Q8BYR2"},{"id":"A90","pred":"Main_UniprotID","subj":"T100","obj":"Q13043"},{"id":"A104","pred":"Main_UniprotID","subj":"T119","obj":"P46938"},{"id":"A119","pred":"Main_UniprotID","subj":"T134","obj":"P46938"},{"id":"A37","pred":"Main_UniprotID","subj":"T37","obj":"Q7TSJ6"},{"id":"A60","pred":"Main_UniprotID","subj":"T60","obj":"Q8BYR2"},{"id":"A105","pred":"Main_UniprotID","subj":"T120","obj":"P46938"},{"id":"A23","pred":"Main_UniprotID","subj":"T23","obj":"Q7TSJ6"},{"id":"A41","pred":"Main_UniprotID","subj":"T41","obj":"Q7TSJ6"},{"id":"A96","pred":"Main_UniprotID","subj":"T106","obj":"Q13188"},{"id":"A125","pred":"Main_UniprotID","subj":"T140","obj":"Q9EPK5"},{"id":"A7","pred":"Main_UniprotID","subj":"T7","obj":"Q7TSJ6"},{"id":"A25","pred":"Main_UniprotID","subj":"T25","obj":"Q7TSJ6"},{"id":"A64","pred":"Main_UniprotID","subj":"T64","obj":"Q8BYR2"},{"id":"A122","pred":"Main_UniprotID","subj":"T137","obj":"Q9EPK5"},{"id":"A11","pred":"Main_UniprotID","subj":"T11","obj":"Q7TSJ6"},{"id":"A30","pred":"Main_UniprotID","subj":"T30","obj":"Q7TSJ6"},{"id":"A50","pred":"Main_UniprotID","subj":"T50","obj":"Q8BYR2"},{"id":"A115","pred":"Main_UniprotID","subj":"T130","obj":"P46938"},{"id":"A128","pred":"Main_UniprotID","subj":"T143","obj":"Q9EPK5"},{"id":"A94","pred":"Main_UniprotID","subj":"T104","obj":"Q13188"},{"id":"A133","pred":"Main_UniprotID","subj":"T148","obj":"Q9EPK5"},{"id":"A138","pred":"Main_UniprotID","subj":"T153","obj":"P15919"},{"id":"A67","pred":"Main_UniprotID","subj":"T67","obj":"Q8BYR2"},{"id":"A129","pred":"Main_UniprotID","subj":"T144","obj":"Q9EPK5"},{"id":"A35","pred":"Main_UniprotID","subj":"T35","obj":"Q7TSJ6"},{"id":"A53","pred":"Main_UniprotID","subj":"T53","obj":"Q8BYR2"},{"id":"A79","pred":"Main_UniprotID","subj":"T79","obj":"Q8BYR2"},{"id":"A99","pred":"Main_UniprotID","subj":"T114","obj":"P46938"},{"id":"A106","pred":"Main_UniprotID","subj":"T121","obj":"P46938"},{"id":"A114","pred":"Main_UniprotID","subj":"T129","obj":"P46938"},{"id":"A38","pred":"Main_UniprotID","subj":"T38","obj":"Q7TSJ6"},{"id":"A45","pred":"Main_UniprotID","subj":"T45","obj":"Q8BYR2"},{"id":"A4","pred":"Main_UniprotID","subj":"T4","obj":"Q7TSJ6"},{"id":"A75","pred":"Main_UniprotID","subj":"T75","obj":"Q8BYR2"},{"id":"A47","pred":"Main_UniprotID","subj":"T47","obj":"Q8BYR2"},{"id":"A59","pred":"Main_UniprotID","subj":"T59","obj":"Q8BYR2"},{"id":"A103","pred":"Main_UniprotID","subj":"T118","obj":"P46938"},{"id":"A42","pred":"Main_UniprotID","subj":"T42","obj":"Q7TSJ6"},{"id":"A48","pred":"Main_UniprotID","subj":"T48","obj":"Q8BYR2"},{"id":"A49","pred":"Main_UniprotID","subj":"T49","obj":"Q8BYR2"},{"id":"A76","pred":"Main_UniprotID","subj":"T76","obj":"Q8BYR2"},{"id":"A130","pred":"Main_UniprotID","subj":"T145","obj":"Q9EPK5"},{"id":"A43","pred":"Main_UniprotID","subj":"T43","obj":"Q7TSJ6"},{"id":"A54","pred":"Main_UniprotID","subj":"T54","obj":"Q8BYR2"},{"id":"A95","pred":"Main_UniprotID","subj":"T105","obj":"Q13188"},{"id":"A100","pred":"Main_UniprotID","subj":"T115","obj":"P46938"},{"id":"A18","pred":"Main_UniprotID","subj":"T18","obj":"Q7TSJ6"},{"id":"A36","pred":"Main_UniprotID","subj":"T36","obj":"Q7TSJ6"},{"id":"A83","pred":"Main_UniprotID","subj":"T83","obj":"Q8BYR2"},{"id":"A135","pred":"Main_UniprotID","subj":"T150","obj":"Q9EPK5"},{"id":"A137","pred":"Main_UniprotID","subj":"T152","obj":"Q9EPK5"},{"id":"A61","pred":"Main_UniprotID","subj":"T61","obj":"Q8BYR2"},{"id":"A89","pred":"Main_UniprotID","subj":"T99","obj":"Q7TSJ6"},{"id":"A14","pred":"Main_UniprotID","subj":"T14","obj":"Q7TSJ6"},{"id":"A80","pred":"Main_UniprotID","subj":"T80","obj":"Q8BYR2"},{"id":"A101","pred":"Main_UniprotID","subj":"T116","obj":"P46938"},{"id":"A71","pred":"Main_UniprotID","subj":"T71","obj":"Q8BYR2"},{"id":"A113","pred":"Main_UniprotID","subj":"T128","obj":"P46938"},{"id":"A85","pred":"Main_UniprotID","subj":"T85","obj":"Q8BYR2"},{"id":"A5","pred":"Main_UniprotID","subj":"T5","obj":"Q7TSJ6"},{"id":"A91","pred":"Main_UniprotID","subj":"T101","obj":"Q13043"},{"id":"A32","pred":"Main_UniprotID","subj":"T32","obj":"Q7TSJ6"},{"id":"A98","pred":"Main_UniprotID","subj":"T113","obj":"P46938"},{"id":"A136","pred":"Main_UniprotID","subj":"T151","obj":"Q9EPK5"},{"id":"A121","pred":"Main_UniprotID","subj":"T136","obj":"Q9EPK5"},{"id":"A55","pred":"Main_UniprotID","subj":"T55","obj":"Q8BYR2"},{"id":"A72","pred":"Main_UniprotID","subj":"T72","obj":"Q8BYR2"},{"id":"A78","pred":"Main_UniprotID","subj":"T78","obj":"Q8BYR2"},{"id":"A82","pred":"Main_UniprotID","subj":"T82","obj":"Q8BYR2"},{"id":"A131","pred":"Main_UniprotID","subj":"T146","obj":"Q9EPK5"},{"id":"A17","pred":"Main_UniprotID","subj":"T17","obj":"Q7TSJ6"},{"id":"A31","pred":"Main_UniprotID","subj":"T31","obj":"Q7TSJ6"},{"id":"A6","pred":"Main_UniprotID","subj":"T6","obj":"Q7TSJ6"},{"id":"A111","pred":"Main_UniprotID","subj":"T126","obj":"P46938"},{"id":"A108","pred":"Main_UniprotID","subj":"T123","obj":"P46938"},{"id":"A109","pred":"Main_UniprotID","subj":"T124","obj":"P46938"},{"id":"A134","pred":"Main_UniprotID","subj":"T149","obj":"Q9EPK5"},{"id":"A26","pred":"Main_UniprotID","subj":"T26","obj":"Q7TSJ6"},{"id":"A40","pred":"Main_UniprotID","subj":"T40","obj":"Q7TSJ6"},{"id":"A70","pred":"Main_UniprotID","subj":"T70","obj":"Q8BYR2"},{"id":"A123","pred":"Main_UniprotID","subj":"T138","obj":"Q9EPK5"},{"id":"A20","pred":"Main_UniprotID","subj":"T20","obj":"Q7TSJ6"},{"id":"A29","pred":"Main_UniprotID","subj":"T29","obj":"Q7TSJ6"},{"id":"A69","pred":"Main_UniprotID","subj":"T69","obj":"Q8BYR2"},{"id":"A24","pred":"Main_UniprotID","subj":"T24","obj":"Q7TSJ6"},{"id":"A9","pred":"Main_UniprotID","subj":"T9","obj":"Q7TSJ6"},{"id":"A56","pred":"Main_UniprotID","subj":"T56","obj":"Q8BYR2"},{"id":"A13","pred":"Main_UniprotID","subj":"T13","obj":"Q7TSJ6"},{"id":"A27","pred":"Main_UniprotID","subj":"T27","obj":"Q7TSJ6"},{"id":"A3","pred":"Main_UniprotID","subj":"T3","obj":"Q7TSJ6"},{"id":"A19","pred":"Main_UniprotID","subj":"T19","obj":"Q7TSJ6"},{"id":"A28","pred":"Main_UniprotID","subj":"T28","obj":"Q7TSJ6"},{"id":"A63","pred":"Main_UniprotID","subj":"T63","obj":"Q8BYR2"},{"id":"A44","pred":"Main_UniprotID","subj":"T44","obj":"Q8BYR2"},{"subj":"T1","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T2","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T3","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T4","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T5","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T6","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T7","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T8","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T9","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T10","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T11","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T12","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T13","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T14","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T15","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T16","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T17","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T18","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T19","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T20","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T21","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T22","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T23","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T24","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T25","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T26","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T27","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T28","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T29","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T30","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T31","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T32","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T33","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T34","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T35","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T36","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T37","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T38","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T39","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T40","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T41","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T42","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T43","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T44","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T45","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T46","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T47","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T48","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T49","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T50","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T51","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T52","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T53","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T54","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T55","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T56","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T57","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T58","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T59","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T60","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T61","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T62","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T63","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T64","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T65","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T66","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T67","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T68","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T69","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T70","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T71","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T72","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T73","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T74","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T75","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T76","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T77","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T78","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T79","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T80","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T81","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T82","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T83","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T84","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T85","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T86","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T88","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T89","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T90","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T91","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T92","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T93","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T94","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T95","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T99","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T100","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T101","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T102","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T104","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T105","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T106","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T107","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T108","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T109","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T112","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T113","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T114","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T115","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T116","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T117","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T118","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T119","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T120","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T121","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T122","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T123","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T124","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T125","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T126","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T127","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T128","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T129","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T130","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T134","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T135","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T136","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T137","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T138","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T139","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T140","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T141","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T142","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T143","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T144","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T145","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T146","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T147","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T148","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T149","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T150","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T151","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T152","pred":"source","obj":"FA_Top107-forWeb"},{"subj":"T153","pred":"source","obj":"FA_Top107-forWeb"}]},{"project":"FA_Top100-Disease","denotations":[{"id":"FirstAuthorDictionay_T1","span":{"begin":30,"end":32},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T101","span":{"begin":5779,"end":5781},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T105","span":{"begin":7335,"end":7337},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T107","span":{"begin":7358,"end":7360},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T109","span":{"begin":7410,"end":7412},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T11","span":{"begin":654,"end":656},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T111","span":{"begin":7456,"end":7458},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T113","span":{"begin":7549,"end":7551},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T115","span":{"begin":7570,"end":7572},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T117","span":{"begin":7822,"end":7824},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T13","span":{"begin":732,"end":736},"obj":"something"},{"id":"FirstAuthorDictionay_T16","span":{"begin":745,"end":747},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T18","span":{"begin":751,"end":753},"obj":"_FRAGMENT"},{"id":"FirstAuthorDictionay_T19","span":{"begin":787,"end":789},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T22","span":{"begin":1582,"end":1584},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T24","span":{"begin":1610,"end":1614},"obj":"something"},{"id":"FirstAuthorDictionay_T29","span":{"begin":1660,"end":1662},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T3","span":{"begin":433,"end":435},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T31","span":{"begin":1668,"end":1670},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T33","span":{"begin":1763,"end":1765},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T35","span":{"begin":1844,"end":1846},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T37","span":{"begin":2455,"end":2457},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T39","span":{"begin":2500,"end":2502},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T41","span":{"begin":2575,"end":2577},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T43","span":{"begin":2648,"end":2650},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T47","span":{"begin":2773,"end":2775},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T49","span":{"begin":2910,"end":2912},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T5","span":{"begin":457,"end":459},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T51","span":{"begin":3006,"end":3008},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T53","span":{"begin":3034,"end":3036},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T55","span":{"begin":3052,"end":3054},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T57","span":{"begin":3238,"end":3240},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T60","span":{"begin":3449,"end":3451},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T62","span":{"begin":3477,"end":3479},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T65","span":{"begin":3662,"end":3664},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T67","span":{"begin":3685,"end":3687},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T69","span":{"begin":3710,"end":3712},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T7","span":{"begin":532,"end":534},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T72","span":{"begin":3796,"end":3798},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T74","span":{"begin":3965,"end":3967},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T76","span":{"begin":3978,"end":3980},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T78","span":{"begin":4006,"end":4008},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T80","span":{"begin":4289,"end":4291},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T82","span":{"begin":4490,"end":4492},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T84","span":{"begin":4600,"end":4602},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T86","span":{"begin":4707,"end":4709},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T88","span":{"begin":4737,"end":4739},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T9","span":{"begin":548,"end":550},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T90","span":{"begin":5371,"end":5373},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T92","span":{"begin":5502,"end":5504},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T94","span":{"begin":5657,"end":5659},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T96","span":{"begin":5702,"end":5704},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T99","span":{"begin":5742,"end":5744},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T1","span":{"begin":1647,"end":1649},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T10","span":{"begin":1422,"end":1424},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T12","span":{"begin":1516,"end":1518},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T13","span":{"begin":1535,"end":1537},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T14","span":{"begin":1593,"end":1595},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T15","span":{"begin":1728,"end":1730},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T16","span":{"begin":1814,"end":1816},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T17","span":{"begin":1859,"end":1861},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T18","span":{"begin":1979,"end":1981},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T19","span":{"begin":2017,"end":2019},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T2","span":{"begin":19,"end":21},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T20","span":{"begin":2067,"end":2069},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T21","span":{"begin":2145,"end":2147},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T22","span":{"begin":2163,"end":2165},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T23","span":{"begin":2236,"end":2238},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T24","span":{"begin":2284,"end":2286},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T25","span":{"begin":2289,"end":2291},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T26","span":{"begin":2415,"end":2417},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T27","span":{"begin":2424,"end":2426},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T28","span":{"begin":2559,"end":2561},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T29","span":{"begin":2596,"end":2598},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T3","span":{"begin":402,"end":404},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T30","span":{"begin":2619,"end":2621},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T31","span":{"begin":2670,"end":2672},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T32","span":{"begin":2708,"end":2710},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T33","span":{"begin":2837,"end":2839},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T34","span":{"begin":2875,"end":2877},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T35","span":{"begin":2953,"end":2955},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T36","span":{"begin":3077,"end":3079},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T37","span":{"begin":3175,"end":3177},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T38","span":{"begin":3210,"end":3212},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T39","span":{"begin":3289,"end":3291},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T4","span":{"begin":514,"end":516},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T40","span":{"begin":3520,"end":3522},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T41","span":{"begin":3735,"end":3737},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T42","span":{"begin":3779,"end":3781},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T43","span":{"begin":4090,"end":4092},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T44","span":{"begin":4174,"end":4176},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T45","span":{"begin":4262,"end":4264},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T46","span":{"begin":4400,"end":4402},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T47","span":{"begin":4532,"end":4534},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T48","span":{"begin":4659,"end":4661},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T5","span":{"begin":591,"end":593},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T51","span":{"begin":4863,"end":4865},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T52","span":{"begin":5326,"end":5328},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T53","span":{"begin":5399,"end":5401},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T54","span":{"begin":5516,"end":5518},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T55","span":{"begin":5554,"end":5556},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T56","span":{"begin":5596,"end":5598},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T57","span":{"begin":5614,"end":5616},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T58","span":{"begin":5685,"end":5687},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T59","span":{"begin":5717,"end":5719},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T6","span":{"begin":605,"end":607},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T60","span":{"begin":5815,"end":5817},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T61","span":{"begin":5857,"end":5859},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T62","span":{"begin":5923,"end":5925},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T63","span":{"begin":5936,"end":5938},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T64","span":{"begin":7374,"end":7376},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T65","span":{"begin":7786,"end":7788},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T66","span":{"begin":7850,"end":7852},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T67","span":{"begin":1510,"end":1514},"obj":"http://purl.obolibrary.org/obo/MONDO_0002691"},{"id":"T68","span":{"begin":3252,"end":3257},"obj":"http://purl.obolibrary.org/obo/MONDO_0005105"},{"id":"T7","span":{"begin":689,"end":691},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T70","span":{"begin":2732,"end":2741},"obj":"http://purl.obolibrary.org/obo/MONDO_0010150"},{"id":"T8","span":{"begin":828,"end":830},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T9","span":{"begin":876,"end":878},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"T71","span":{"begin":745,"end":748},"obj":"something"}],"relations":[{"id":"R1","pred":"_lexicallyChainedTo","subj":"T71","obj":"FirstAuthorDictionay_T18"}],"attributes":[{"subj":"FirstAuthorDictionay_T1","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T101","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T105","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T107","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T109","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T11","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T111","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T113","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T115","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T117","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T13","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T16","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T18","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T19","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T22","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T24","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T29","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T3","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T31","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T33","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T35","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T37","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T39","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T41","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T43","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T47","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T49","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T5","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T51","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T53","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T55","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T57","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T60","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T62","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T65","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T67","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T69","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T7","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T72","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T74","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T76","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T78","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T80","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T82","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T84","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T86","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T88","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T9","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T90","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T92","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T94","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T96","pred":"source","obj":"FA_Top100-Disease"},{"subj":"FirstAuthorDictionay_T99","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T1","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T10","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T12","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T13","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T14","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T15","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T16","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T17","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T18","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T19","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T2","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T20","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T21","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T22","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T23","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T24","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T25","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T26","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T27","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T28","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T29","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T3","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T30","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T31","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T32","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T33","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T34","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T35","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T36","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T37","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T38","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T39","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T4","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T40","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T41","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T42","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T43","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T44","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T45","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T46","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T47","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T48","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T5","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T51","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T52","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T53","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T54","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T55","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T56","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T57","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T58","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T59","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T6","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T60","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T61","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T62","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T63","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T64","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T65","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T66","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T67","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T68","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T7","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T70","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T8","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T9","pred":"source","obj":"FA_Top100-Disease"},{"subj":"T71","pred":"source","obj":"FA_Top100-Disease"}]},{"project":"FA_Top100Plus-GeneProtein","denotations":[{"id":"T96","span":{"begin":6,"end":15},"obj":"DEL"},{"id":"T48","span":{"begin":184,"end":189},"obj":"UniProtKB:Q8BYR2"},{"id":"T46","span":{"begin":184,"end":188},"obj":"UniProtKB:_FRAGMENT"},{"id":"T94","span":{"begin":190,"end":191},"obj":"UniProtKB:Q7TSJ6"},{"id":"T95","span":{"begin":383,"end":392},"obj":"DEL"},{"id":"T97","span":{"begin":441,"end":450},"obj":"DEL"},{"id":"T98","span":{"begin":474,"end":483},"obj":"DEL"},{"id":"T3","span":{"begin":500,"end":505},"obj":"UniProtKB:Q8BYR2"},{"id":"T49","span":{"begin":508,"end":513},"obj":"UniProtKB:Q7TSJ6"},{"id":"T4","span":{"begin":567,"end":572},"obj":"UniProtKB:Q8BYR2"},{"id":"T50","span":{"begin":575,"end":580},"obj":"UniProtKB:Q7TSJ6"},{"id":"T99","span":{"begin":641,"end":650},"obj":"DEL"},{"id":"T1","span":{"begin":675,"end":680},"obj":"UniProtKB:Q8BYR2"},{"id":"T51","span":{"begin":683,"end":688},"obj":"UniProtKB:Q7TSJ6"},{"id":"T100","span":{"begin":811,"end":820},"obj":"DEL"},{"id":"T101","span":{"begin":863,"end":872},"obj":"DEL"},{"id":"T102","span":{"begin":940,"end":949},"obj":"DEL"},{"id":"T139","span":{"begin":957,"end":961},"obj":"UniProtKB:Q13043"},{"id":"T143","span":{"begin":964,"end":968},"obj":"UniProtKB:Q13188"},{"id":"T146","span":{"begin":969,"end":983},"obj":"DEL"},{"id":"T148","span":{"begin":984,"end":990},"obj":"UniProtKB:Q92918"},{"id":"T153","span":{"begin":990,"end":991},"obj":"UniProtKB:Q8N4C8"},{"id":"T152","span":{"begin":990,"end":991},"obj":"UniProtKB:Q9Y4K4"},{"id":"T151","span":{"begin":990,"end":991},"obj":"UniProtKB:O95819"},{"id":"T150","span":{"begin":990,"end":991},"obj":"UniProtKB:Q8IVH8"},{"id":"T149","span":{"begin":990,"end":991},"obj":"UniProtKB:Q12851"},{"id":"T154","span":{"begin":991,"end":997},"obj":"UniProtKB:something"},{"id":"T5","span":{"begin":999,"end":1004},"obj":"UniProtKB:O95835"},{"id":"T52","span":{"begin":1007,"end":1012},"obj":"UniProtKB:Q9NRM7"},{"id":"T103","span":{"begin":1034,"end":1043},"obj":"DEL"},{"id":"T140","span":{"begin":1061,"end":1065},"obj":"UniProtKB:Q13043"},{"id":"T144","span":{"begin":1068,"end":1072},"obj":"UniProtKB:Q13188"},{"id":"T147","span":{"begin":1075,"end":1089},"obj":"DEL"},{"id":"T155","span":{"begin":1100,"end":1105},"obj":"UniProtKB:O95835"},{"id":"T156","span":{"begin":1108,"end":1113},"obj":"UniProtKB:Q9NRM7"},{"id":"T7","span":{"begin":1132,"end":1137},"obj":"PR:000009686"},{"id":"T54","span":{"begin":1140,"end":1145},"obj":"PR:000009687"},{"id":"T104","span":{"begin":1146,"end":1155},"obj":"DEL"},{"id":"T157","span":{"begin":1178,"end":1181},"obj":"PR:000017522"},{"id":"T179","span":{"begin":1184,"end":1187},"obj":"PR:000017466"},{"id":"T158","span":{"begin":1203,"end":1206},"obj":"PR:000017522"},{"id":"T180","span":{"begin":1209,"end":1212},"obj":"PR:000017466"},{"id":"T200","span":{"begin":1239,"end":1244},"obj":"PR:000009686"},{"id":"T201","span":{"begin":1247,"end":1252},"obj":"PR:000009687"},{"id":"T105","span":{"begin":1260,"end":1269},"obj":"DEL"},{"id":"T159","span":{"begin":1282,"end":1285},"obj":"PR:000017522"},{"id":"T181","span":{"begin":1288,"end":1291},"obj":"PR:000017466"},{"id":"T106","span":{"begin":1323,"end":1332},"obj":"DEL"},{"id":"T202","span":{"begin":1342,"end":1347},"obj":"PR:000009686"},{"id":"T203","span":{"begin":1350,"end":1355},"obj":"PR:000009687"},{"id":"T160","span":{"begin":1370,"end":1373},"obj":"PR:000017522"},{"id":"T182","span":{"begin":1376,"end":1379},"obj":"PR:000017466"},{"id":"T107","span":{"begin":1403,"end":1412},"obj":"DEL"},{"id":"T141","span":{"begin":1469,"end":1473},"obj":"UniProtKB:Q9JI11"},{"id":"T145","span":{"begin":1476,"end":1480},"obj":"UniProtKB:Q9JI10"},{"id":"T161","span":{"begin":1496,"end":1499},"obj":"UniProtKB:P46938"},{"id":"T108","span":{"begin":1553,"end":1562},"obj":"DEL"},{"id":"T109","span":{"begin":1634,"end":1643},"obj":"DEL"},{"id":"T10","span":{"begin":1710,"end":1715},"obj":"UniProtKB:Q8BYR2"},{"id":"T57","span":{"begin":1718,"end":1723},"obj":"UniProtKB:Q7TSJ6"},{"id":"T110","span":{"begin":1771,"end":1780},"obj":"DEL"},{"id":"T111","span":{"begin":1867,"end":1876},"obj":"DEL"},{"id":"T112","span":{"begin":1908,"end":1917},"obj":"DEL"},{"id":"T162","span":{"begin":1938,"end":1941},"obj":"UniProtKB:P46938"},{"id":"T183","span":{"begin":1944,"end":1947},"obj":"UniProtKB:Q9EPK5"},{"id":"T113","span":{"begin":1987,"end":1996},"obj":"DEL"},{"id":"T114","span":{"begin":2026,"end":2035},"obj":"DEL"},{"id":"T115","span":{"begin":2075,"end":2084},"obj":"DEL"},{"id":"T11","span":{"begin":2124,"end":2129},"obj":"UniProtKB:Q8BYR2"},{"id":"T58","span":{"begin":2132,"end":2137},"obj":"UniProtKB:Q7TSJ6"},{"id":"T204","span":{"begin":2182,"end":2185},"obj":"UniProtKB:P46938"},{"id":"T207","span":{"begin":2188,"end":2191},"obj":"UniProtKB:Q9EPK5"},{"id":"T12","span":{"begin":2218,"end":2223},"obj":"UniProtKB:Q8BYR2"},{"id":"T59","span":{"begin":2226,"end":2231},"obj":"UniProtKB:Q7TSJ6"},{"id":"T205","span":{"begin":2245,"end":2248},"obj":"UniProtKB:P46938"},{"id":"T208","span":{"begin":2251,"end":2254},"obj":"UniProtKB:Q9EPK5"},{"id":"T206","span":{"begin":2335,"end":2338},"obj":"UniProtKB:P46938"},{"id":"T209","span":{"begin":2341,"end":2344},"obj":"UniProtKB:Q9EPK5"},{"id":"T13","span":{"begin":2397,"end":2402},"obj":"UniProtKB:Q8BYR2"},{"id":"T60","span":{"begin":2405,"end":2410},"obj":"UniProtKB:Q7TSJ6"},{"id":"T14","span":{"begin":2463,"end":2468},"obj":"UniProtKB:Q8BYR2"},{"id":"T61","span":{"begin":2471,"end":2476},"obj":"UniProtKB:Q7TSJ6"},{"id":"T211","span":{"begin":2480,"end":2483},"obj":"UniProtKB:P46938"},{"id":"T210","span":{"begin":2486,"end":2489},"obj":"UniProtKB:Q9EPK5"},{"id":"T15","span":{"begin":2541,"end":2546},"obj":"UniProtKB:Q8BYR2"},{"id":"T62","span":{"begin":2549,"end":2554},"obj":"UniProtKB:Q7TSJ6"},{"id":"T16","span":{"begin":2601,"end":2606},"obj":"UniProtKB:Q8BYR2"},{"id":"T63","span":{"begin":2609,"end":2614},"obj":"UniProtKB:Q7TSJ6"},{"id":"T17","span":{"begin":2680,"end":2685},"obj":"UniProtKB:Q8BYR2"},{"id":"T64","span":{"begin":2688,"end":2693},"obj":"UniProtKB:Q7TSJ6"},{"id":"T18","span":{"begin":2800,"end":2805},"obj":"UniProtKB:Q8BYR2"},{"id":"T65","span":{"begin":2808,"end":2813},"obj":"UniProtKB:Q7TSJ6"},{"id":"T19","span":{"begin":2858,"end":2863},"obj":"UniProtKB:Q8BYR2"},{"id":"T66","span":{"begin":2866,"end":2871},"obj":"UniProtKB:Q7TSJ6"},{"id":"T116","span":{"begin":2940,"end":2949},"obj":"DEL"},{"id":"T20","span":{"begin":3014,"end":3019},"obj":"UniProtKB:Q8BYR2"},{"id":"T67","span":{"begin":3022,"end":3027},"obj":"UniProtKB:Q7TSJ6"},{"id":"T21","span":{"begin":3060,"end":3065},"obj":"UniProtKB:Q8BYR2"},{"id":"T68","span":{"begin":3068,"end":3073},"obj":"UniProtKB:Q7TSJ6"},{"id":"T22","span":{"begin":3192,"end":3197},"obj":"UniProtKB:Q8BYR2"},{"id":"T69","span":{"begin":3200,"end":3205},"obj":"UniProtKB:Q7TSJ6"},{"id":"T23","span":{"begin":3271,"end":3276},"obj":"UniProtKB:Q8BYR2"},{"id":"T70","span":{"begin":3279,"end":3284},"obj":"UniProtKB:Q7TSJ6"},{"id":"T212","span":{"begin":3346,"end":3351},"obj":"Gene ID:19373"},{"id":"T24","span":{"begin":3380,"end":3385},"obj":"UniProtKB:Q8BYR2"},{"id":"T71","span":{"begin":3388,"end":3393},"obj":"UniProtKB:Q7TSJ6"},{"id":"T25","span":{"begin":3412,"end":3417},"obj":"UniProtKB:Q8BYR2"},{"id":"T72","span":{"begin":3420,"end":3425},"obj":"UniProtKB:Q7TSJ6"},{"id":"T26","span":{"begin":3485,"end":3490},"obj":"UniProtKB:Q8BYR2"},{"id":"T73","span":{"begin":3493,"end":3498},"obj":"UniProtKB:Q7TSJ6"},{"id":"T27","span":{"begin":3542,"end":3547},"obj":"UniProtKB:Q8BYR2"},{"id":"T74","span":{"begin":3550,"end":3555},"obj":"UniProtKB:Q7TSJ6"},{"id":"T28","span":{"begin":3693,"end":3698},"obj":"UniProtKB:Q8BYR2"},{"id":"T75","span":{"begin":3701,"end":3706},"obj":"UniProtKB:Q7TSJ6"},{"id":"T29","span":{"begin":3761,"end":3766},"obj":"UniProtKB:Q8BYR2"},{"id":"T76","span":{"begin":3769,"end":3774},"obj":"UniProtKB:Q7TSJ6"},{"id":"T30","span":{"begin":3808,"end":3813},"obj":"UniProtKB:Q8BYR2"},{"id":"T77","span":{"begin":3816,"end":3821},"obj":"UniProtKB:Q7TSJ6"},{"id":"T167","span":{"begin":3825,"end":3828},"obj":"UniProtKB:P46938"},{"id":"T188","span":{"begin":3831,"end":3834},"obj":"UniProtKB:Q9EPK5"},{"id":"T214","span":{"begin":3848,"end":3851},"obj":"UniProtKB:P46938"},{"id":"T216","span":{"begin":3855,"end":3858},"obj":"UniProtKB:Q9EPK5"},{"id":"T213","span":{"begin":3894,"end":3897},"obj":"UniProtKB:P46938"},{"id":"T215","span":{"begin":3904,"end":3907},"obj":"UniProtKB:Q9EPK5"},{"id":"T31","span":{"begin":3926,"end":3931},"obj":"UniProtKB:Q8BYR2"},{"id":"T78","span":{"begin":3934,"end":3939},"obj":"UniProtKB:Q7TSJ6"},{"id":"T32","span":{"begin":3986,"end":3991},"obj":"UniProtKB:Q8BYR2"},{"id":"T79","span":{"begin":3994,"end":3999},"obj":"UniProtKB:Q7TSJ6"},{"id":"T33","span":{"begin":4072,"end":4077},"obj":"UniProtKB:Q8BYR2"},{"id":"T80","span":{"begin":4080,"end":4085},"obj":"UniProtKB:Q7TSJ6"},{"id":"T34","span":{"begin":4156,"end":4161},"obj":"UniProtKB:Q8BYR2"},{"id":"T81","span":{"begin":4164,"end":4169},"obj":"UniProtKB:Q7TSJ6"},{"id":"T35","span":{"begin":4244,"end":4249},"obj":"PR:000009686"},{"id":"T82","span":{"begin":4252,"end":4257},"obj":"PR:000009687"},{"id":"T36","span":{"begin":4382,"end":4387},"obj":"UniProtKB:Q8BYR2"},{"id":"T83","span":{"begin":4390,"end":4395},"obj":"UniProtKB:Q7TSJ6"},{"id":"T217","span":{"begin":4437,"end":4445},"obj":"DEL"},{"id":"T220","span":{"begin":4446,"end":4454},"obj":"DEL"},{"id":"T37","span":{"begin":4471,"end":4476},"obj":"UniProtKB:Q8BYR2"},{"id":"T84","span":{"begin":4479,"end":4484},"obj":"UniProtKB:Q7TSJ6"},{"id":"T234","span":{"begin":4514,"end":4519},"obj":"UniProtKB:Q8BYR2"},{"id":"T235","span":{"begin":4522,"end":4527},"obj":"UniProtKB:Q7TSJ6"},{"id":"T218","span":{"begin":4570,"end":4578},"obj":"DEL"},{"id":"T221","span":{"begin":4579,"end":4587},"obj":"DEL"},{"id":"T117","span":{"begin":4640,"end":4649},"obj":"DEL"},{"id":"T118","span":{"begin":4715,"end":4724},"obj":"DEL"},{"id":"T119","span":{"begin":4772,"end":4781},"obj":"DEL"},{"id":"T120","span":{"begin":4827,"end":4836},"obj":"DEL"},{"id":"T121","span":{"begin":4901,"end":4910},"obj":"DEL"},{"id":"T122","span":{"begin":4957,"end":4966},"obj":"DEL"},{"id":"T170","span":{"begin":4970,"end":4973},"obj":"UniProtKB:P46938"},{"id":"T191","span":{"begin":4976,"end":4979},"obj":"UniProtKB:Q9EPK5"},{"id":"T123","span":{"begin":5037,"end":5046},"obj":"DEL"},{"id":"T226","span":{"begin":5054,"end":5057},"obj":"UniProtKB:P46938"},{"id":"T229","span":{"begin":5060,"end":5063},"obj":"UniProtKB:Q9EPK5"},{"id":"T227","span":{"begin":5090,"end":5093},"obj":"UniProtKB:P46938"},{"id":"T230","span":{"begin":5096,"end":5099},"obj":"UniProtKB:Q9EPK5"},{"id":"T124","span":{"begin":5111,"end":5120},"obj":"DEL"},{"id":"T228","span":{"begin":5157,"end":5160},"obj":"UniProtKB:P46938"},{"id":"T231","span":{"begin":5163,"end":5166},"obj":"UniProtKB:Q9EPK5"},{"id":"T125","span":{"begin":5191,"end":5200},"obj":"DEL"},{"id":"T39","span":{"begin":5230,"end":5235},"obj":"UniProtKB:Q8BYR2"},{"id":"T86","span":{"begin":5238,"end":5243},"obj":"UniProtKB:Q7TSJ6"},{"id":"T126","span":{"begin":5258,"end":5267},"obj":"DEL"},{"id":"T233","span":{"begin":5293,"end":5296},"obj":"UniProtKB:P46938"},{"id":"T232","span":{"begin":5299,"end":5302},"obj":"UniProtKB:Q9EPK5"},{"id":"T127","span":{"begin":5352,"end":5361},"obj":"DEL"},{"id":"T128","span":{"begin":5423,"end":5432},"obj":"DEL"},{"id":"T129","span":{"begin":5470,"end":5479},"obj":"DEL"},{"id":"T40","span":{"begin":5665,"end":5670},"obj":"UniProtKB:Q8BYR2"},{"id":"T87","span":{"begin":5673,"end":5678},"obj":"UniProtKB:Q7TSJ6"},{"id":"T41","span":{"begin":5750,"end":5755},"obj":"UniProtKB:O95835"},{"id":"T88","span":{"begin":5758,"end":5763},"obj":"UniProtKB:Q9NRM7"},{"id":"T130","span":{"begin":5863,"end":5872},"obj":"DEL"},{"id":"T42","span":{"begin":5902,"end":5907},"obj":"UniProtKB:O95835"},{"id":"T89","span":{"begin":5910,"end":5915},"obj":"UniProtKB:Q9NRM7"},{"id":"T132","span":{"begin":7343,"end":7352},"obj":"DEL"},{"id":"T44","span":{"begin":7418,"end":7423},"obj":"UniProtKB:Q8BYR2"},{"id":"T90","span":{"begin":7426,"end":7431},"obj":"UniProtKB:Q7TSJ6"},{"id":"T133","span":{"begin":7437,"end":7446},"obj":"DEL"},{"id":"T219","span":{"begin":7501,"end":7509},"obj":"DEL"},{"id":"T222","span":{"begin":7510,"end":7518},"obj":"DEL"},{"id":"T223","span":{"begin":7533,"end":7543},"obj":"DEL"},{"id":"T134","span":{"begin":7591,"end":7600},"obj":"DEL"},{"id":"T135","span":{"begin":7629,"end":7638},"obj":"DEL"},{"id":"T178","span":{"begin":7642,"end":7645},"obj":"UniProtKB:P46938"},{"id":"T199","span":{"begin":7648,"end":7651},"obj":"UniProtKB:Q9EPK5"},{"id":"T136","span":{"begin":7691,"end":7700},"obj":"DEL"},{"id":"T45","span":{"begin":7742,"end":7747},"obj":"UniProtKB:Q8BYR2"},{"id":"T91","span":{"begin":7750,"end":7755},"obj":"UniProtKB:Q7TSJ6"},{"id":"T137","span":{"begin":7803,"end":7812},"obj":"DEL"},{"id":"T138","span":{"begin":7874,"end":7883},"obj":"DEL"}],"attributes":[{"id":"A107","pred":"type","subj":"T110","obj":"Protein"},{"id":"A151","pred":"out_of_scope","subj":"T110","obj":"t"},{"id":"A373","pred":"type","subj":"T207","obj":"Protein"},{"id":"A374","pred":"original paper","subj":"T207","obj":"org_arg"},{"id":"A403","pred":"type","subj":"T221","obj":"Protein"},{"id":"A407","pred":"out_of_scope","subj":"T221","obj":"t"},{"id":"A438","pred":"type","subj":"T235","obj":"Protein"},{"id":"A26","pred":"type","subj":"T26","obj":"Protein"},{"id":"A111","pred":"type","subj":"T114","obj":"Protein"},{"id":"A112","pred":"type","subj":"T115","obj":"Protein"},{"id":"A155","pred":"out_of_scope","subj":"T114","obj":"t"},{"id":"A156","pred":"out_of_scope","subj":"T115","obj":"t"},{"id":"A221","pred":"type","subj":"T155","obj":"Protein"},{"id":"A222","pred":"original paper","subj":"T155","obj":"org_arg"},{"id":"A248","pred":"type","subj":"T178","obj":"Protein"},{"id":"A292","pred":"original paper","subj":"T178","obj":"org_arg"},{"id":"A103","pred":"type","subj":"T106","obj":"Protein"},{"id":"A123","pred":"type","subj":"T126","obj":"Protein"},{"id":"A147","pred":"out_of_scope","subj":"T106","obj":"t"},{"id":"A167","pred":"out_of_scope","subj":"T126","obj":"t"},{"id":"A225","pred":"species","subj":"T7","obj":"general"},{"id":"A7","pred":"type","subj":"T7","obj":"Protein"},{"id":"A223","pred":"type","subj":"T156","obj":"Protein"},{"id":"A224","pred":"original paper","subj":"T156","obj":"org_arg"},{"id":"A386","pred":"type","subj":"T214","obj":"Protein"},{"id":"A387","pred":"original paper","subj":"T214","obj":"org_arg"},{"id":"A10","pred":"type","subj":"T10","obj":"Protein"},{"id":"A15","pred":"type","subj":"T15","obj":"Protein"},{"id":"A215","pred":"type","subj":"T154","obj":"Protein"},{"id":"A216","pred":"original paper","subj":"T154","obj":"org_arg"},{"id":"A217","pred":"uncertain","subj":"T154","obj":"true"},{"id":"A218","pred":"not_found","subj":"T154","obj":"true"},{"id":"A404","pred":"type","subj":"T222","obj":"Protein"},{"id":"A408","pred":"out_of_scope","subj":"T222","obj":"t"},{"id":"A377","pred":"type","subj":"T209","obj":"Protein"},{"id":"A378","pred":"original paper","subj":"T209","obj":"org_arg"},{"id":"A71","pred":"type","subj":"T73","obj":"Protein"},{"id":"A134","pred":"type","subj":"T137","obj":"Protein"},{"id":"A178","pred":"out_of_scope","subj":"T137","obj":"t"},{"id":"A226","pred":"species","subj":"T54","obj":"general"},{"id":"A402","pred":"type","subj":"T220","obj":"Protein"},{"id":"A406","pred":"out_of_scope","subj":"T220","obj":"t"},{"id":"A52","pred":"type","subj":"T54","obj":"Protein"},{"id":"A76","pred":"type","subj":"T78","obj":"Protein"},{"id":"A129","pred":"type","subj":"T132","obj":"Protein"},{"id":"A173","pred":"out_of_scope","subj":"T132","obj":"t"},{"id":"A206","pred":"type","subj":"T151","obj":"Protein"},{"id":"A207","pred":"original paper","subj":"T151","obj":"org_arg"},{"id":"A208","pred":"EngName","subj":"T151","obj":"MAP4K4"},{"id":"A237","pred":"type","subj":"T167","obj":"Protein"},{"id":"A281","pred":"original paper","subj":"T167","obj":"org_arg"},{"id":"A390","pred":"type","subj":"T216","obj":"Protein"},{"id":"A391","pred":"original paper","subj":"T216","obj":"org_arg"},{"id":"A64","pred":"type","subj":"T66","obj":"Protein"},{"id":"A36","pred":"type","subj":"T36","obj":"Protein"},{"id":"A133","pred":"type","subj":"T136","obj":"Protein"},{"id":"A177","pred":"out_of_scope","subj":"T136","obj":"t"},{"id":"A305","pred":"type","subj":"T191","obj":"Protein"},{"id":"A347","pred":"original paper","subj":"T191","obj":"org_arg"},{"id":"A66","pred":"type","subj":"T68","obj":"Protein"},{"id":"A140","pred":"out_of_scope","subj":"T99","obj":"t"},{"id":"A28","pred":"type","subj":"T28","obj":"Protein"},{"id":"A56","pred":"type","subj":"T58","obj":"Protein"},{"id":"A96","pred":"type","subj":"T99","obj":"Protein"},{"id":"A109","pred":"type","subj":"T112","obj":"Protein"},{"id":"A135","pred":"type","subj":"T138","obj":"Protein"},{"id":"A141","pred":"out_of_scope","subj":"T100","obj":"t"},{"id":"A153","pred":"out_of_scope","subj":"T112","obj":"t"},{"id":"A179","pred":"out_of_scope","subj":"T138","obj":"t"},{"id":"A229","pred":"type","subj":"T159","obj":"Protein"},{"id":"A251","pred":"species","subj":"T159","obj":"general"},{"id":"A273","pred":"original paper","subj":"T159","obj":"org_arg"},{"id":"A44","pred":"type","subj":"T44","obj":"Protein"},{"id":"A57","pred":"type","subj":"T59","obj":"Protein"},{"id":"A97","pred":"type","subj":"T100","obj":"Protein"},{"id":"A194","pred":"type","subj":"T146","obj":"Protein"},{"id":"A196","pred":"out_of_scope","subj":"T146","obj":"t"},{"id":"A85","pred":"type","subj":"T87","obj":"Protein"},{"id":"A104","pred":"type","subj":"T107","obj":"Protein"},{"id":"A148","pred":"out_of_scope","subj":"T107","obj":"t"},{"id":"A220","pred":"original paper","subj":"T52","obj":"org_arg"},{"id":"A228","pred":"type","subj":"T158","obj":"Protein"},{"id":"A250","pred":"species","subj":"T158","obj":"general"},{"id":"A272","pred":"original paper","subj":"T158","obj":"org_arg"},{"id":"A3","pred":"type","subj":"T3","obj":"Protein"},{"id":"A379","pred":"type","subj":"T210","obj":"Protein"},{"id":"A380","pred":"original paper","subj":"T210","obj":"org_arg"},{"id":"A41","pred":"type","subj":"T41","obj":"Protein"},{"id":"A50","pred":"type","subj":"T52","obj":"Protein"},{"id":"A106","pred":"type","subj":"T109","obj":"Protein"},{"id":"A138","pred":"out_of_scope","subj":"T97","obj":"t"},{"id":"A150","pred":"out_of_scope","subj":"T109","obj":"t"},{"id":"A358","pred":"type","subj":"T201","obj":"Protein"},{"id":"A359","pred":"species","subj":"T201","obj":"general"},{"id":"A94","pred":"type","subj":"T97","obj":"Protein"},{"id":"A100","pred":"type","subj":"T103","obj":"Protein"},{"id":"A144","pred":"out_of_scope","subj":"T103","obj":"t"},{"id":"A190","pred":"type","subj":"T145","obj":"Protein"},{"id":"A193","pred":"original paper","subj":"T145","obj":"org_arg"},{"id":"A365","pred":"note","subj":"T145","obj":"refの5自体はhumanなのだが、レビューで\"マウス\"と明記しているので、生物種マウスのIDにしておく。"},{"id":"A69","pred":"type","subj":"T71","obj":"Protein"},{"id":"A108","pred":"type","subj":"T111","obj":"Protein"},{"id":"A152","pred":"out_of_scope","subj":"T111","obj":"t"},{"id":"A195","pred":"type","subj":"T147","obj":"Protein"},{"id":"A197","pred":"out_of_scope","subj":"T147","obj":"t"},{"id":"A46","pred":"type","subj":"T48","obj":"Protein"},{"id":"A119","pred":"type","subj":"T122","obj":"Protein"},{"id":"A136","pred":"out_of_scope","subj":"T95","obj":"t"},{"id":"A163","pred":"out_of_scope","subj":"T122","obj":"t"},{"id":"A189","pred":"type","subj":"T144","obj":"Protein"},{"id":"A192","pred":"original paper","subj":"T144","obj":"org_arg"},{"id":"A297","pred":"type","subj":"T183","obj":"Protein"},{"id":"A339","pred":"original paper","subj":"T183","obj":"org_arg"},{"id":"A425","pred":"type","subj":"T229","obj":"Protein"},{"id":"A426","pred":"original paper","subj":"T229","obj":"org_arg"},{"id":"A433","pred":"type","subj":"T233","obj":"Protein"},{"id":"A434","pred":"original paper","subj":"T233","obj":"org_arg"},{"id":"A68","pred":"type","subj":"T70","obj":"Protein"},{"id":"A74","pred":"type","subj":"T76","obj":"Protein"},{"id":"A92","pred":"type","subj":"T95","obj":"Protein"},{"id":"A115","pred":"type","subj":"T118","obj":"Protein"},{"id":"A12","pred":"type","subj":"T12","obj":"Protein"},{"id":"A124","pred":"type","subj":"T127","obj":"Protein"},{"id":"A159","pred":"out_of_scope","subj":"T118","obj":"t"},{"id":"A168","pred":"out_of_scope","subj":"T127","obj":"t"},{"id":"A21","pred":"type","subj":"T21","obj":"Protein"},{"id":"A231","pred":"type","subj":"T161","obj":"Protein"},{"id":"A275","pred":"original paper","subj":"T161","obj":"org_arg"},{"id":"A366","pred":"note","subj":"T161","obj":"refの5自体はhumanなのだが、レビューで\"マウス\"と明記しているので、生物種マウスのIDにしておく。"},{"id":"A371","pred":"type","subj":"T206","obj":"Protein"},{"id":"A372","pred":"original paper","subj":"T206","obj":"org_arg"},{"id":"A27","pred":"type","subj":"T27","obj":"Protein"},{"id":"A313","pred":"type","subj":"T199","obj":"Protein"},{"id":"A355","pred":"original paper","subj":"T199","obj":"org_arg"},{"id":"A130","pred":"type","subj":"T133","obj":"Protein"},{"id":"A174","pred":"out_of_scope","subj":"T133","obj":"t"},{"id":"A294","pred":"type","subj":"T180","obj":"Protein"},{"id":"A315","pred":"species","subj":"T180","obj":"general"},{"id":"A336","pred":"original paper","subj":"T180","obj":"org_arg"},{"id":"A360","pred":"type","subj":"T202","obj":"Protein"},{"id":"A361","pred":"species","subj":"T202","obj":"general"},{"id":"A381","pred":"type","subj":"T211","obj":"Protein"},{"id":"A382","pred":"original paper","subj":"T211","obj":"org_arg"},{"id":"A232","pred":"type","subj":"T162","obj":"Protein"},{"id":"A276","pred":"original paper","subj":"T162","obj":"org_arg"},{"id":"A42","pred":"type","subj":"T42","obj":"Protein"},{"id":"A60","pred":"type","subj":"T62","obj":"Protein"},{"id":"A13","pred":"type","subj":"T13","obj":"Protein"},{"id":"A20","pred":"type","subj":"T20","obj":"Protein"},{"id":"A384","pred":"type","subj":"T213","obj":"Protein"},{"id":"A385","pred":"original paper","subj":"T213","obj":"org_arg"},{"id":"A431","pred":"type","subj":"T232","obj":"Protein"},{"id":"A432","pred":"original paper","subj":"T232","obj":"org_arg"},{"id":"A219","pred":"original paper","subj":"T5","obj":"org_arg"},{"id":"A31","pred":"type","subj":"T31","obj":"Protein"},{"id":"A362","pred":"type","subj":"T203","obj":"Protein"},{"id":"A363","pred":"species","subj":"T203","obj":"general"},{"id":"A5","pred":"type","subj":"T5","obj":"Protein"},{"id":"A79","pred":"type","subj":"T81","obj":"Protein"},{"id":"A142","pred":"out_of_scope","subj":"T101","obj":"t"},{"id":"A19","pred":"type","subj":"T19","obj":"Protein"},{"id":"A37","pred":"type","subj":"T37","obj":"Protein"},{"id":"A398","pred":"type","subj":"T219","obj":"Protein"},{"id":"A4","pred":"type","subj":"T4","obj":"Protein"},{"id":"A401","pred":"out_of_scope","subj":"T219","obj":"t"},{"id":"A58","pred":"type","subj":"T60","obj":"Protein"},{"id":"A98","pred":"type","subj":"T101","obj":"Protein"},{"id":"A230","pred":"type","subj":"T160","obj":"Protein"},{"id":"A24","pred":"type","subj":"T24","obj":"Protein"},{"id":"A252","pred":"species","subj":"T160","obj":"general"},{"id":"A274","pred":"original paper","subj":"T160","obj":"org_arg"},{"id":"A116","pred":"type","subj":"T119","obj":"Protein"},{"id":"A160","pred":"out_of_scope","subj":"T119","obj":"t"},{"id":"A35","pred":"type","subj":"T35","obj":"Protein"},{"id":"A392","pred":"species","subj":"T35","obj":"general"},{"id":"A198","pred":"type","subj":"T148","obj":"Protein"},{"id":"A199","pred":"original paper","subj":"T148","obj":"org_arg"},{"id":"A47","pred":"type","subj":"T49","obj":"Protein"},{"id":"A87","pred":"type","subj":"T89","obj":"Protein"},{"id":"A132","pred":"type","subj":"T135","obj":"Protein"},{"id":"A176","pred":"out_of_scope","subj":"T135","obj":"t"},{"id":"A84","pred":"type","subj":"T86","obj":"Protein"},{"id":"A105","pred":"type","subj":"T108","obj":"Protein"},{"id":"A149","pred":"out_of_scope","subj":"T108","obj":"t"},{"id":"A383","pred":"type","subj":"T212","obj":"Gene"},{"id":"A388","pred":"type","subj":"T215","obj":"Protein"},{"id":"A389","pred":"original paper","subj":"T215","obj":"org_arg"},{"id":"A419","pred":"type","subj":"T226","obj":"Protein"},{"id":"A420","pred":"original paper","subj":"T226","obj":"org_arg"},{"id":"A118","pred":"type","subj":"T121","obj":"Protein"},{"id":"A139","pred":"out_of_scope","subj":"T98","obj":"t"},{"id":"A162","pred":"out_of_scope","subj":"T121","obj":"t"},{"id":"A423","pred":"type","subj":"T228","obj":"Protein"},{"id":"A424","pred":"original paper","subj":"T228","obj":"org_arg"},{"id":"A427","pred":"type","subj":"T230","obj":"Protein"},{"id":"A428","pred":"original paper","subj":"T230","obj":"org_arg"},{"id":"A437","pred":"type","subj":"T234","obj":"Protein"},{"id":"A45","pred":"type","subj":"T45","obj":"Protein"},{"id":"A95","pred":"type","subj":"T98","obj":"Protein"},{"id":"A212","pred":"type","subj":"T153","obj":"Protein"},{"id":"A213","pred":"original paper","subj":"T153","obj":"org_arg"},{"id":"A214","pred":"EngName","subj":"T153","obj":"MAP4K6"},{"id":"A302","pred":"type","subj":"T188","obj":"Protein"},{"id":"A344","pred":"original paper","subj":"T188","obj":"org_arg"},{"id":"A396","pred":"type","subj":"T217","obj":"Protein"},{"id":"A399","pred":"out_of_scope","subj":"T217","obj":"t"},{"id":"A88","pred":"type","subj":"T90","obj":"Protein"},{"id":"A227","pred":"type","subj":"T157","obj":"Protein"},{"id":"A23","pred":"type","subj":"T23","obj":"Protein"},{"id":"A249","pred":"species","subj":"T157","obj":"general"},{"id":"A271","pred":"original paper","subj":"T157","obj":"org_arg"},{"id":"A77","pred":"type","subj":"T79","obj":"Protein"},{"id":"A203","pred":"type","subj":"T150","obj":"Protein"},{"id":"A204","pred":"original paper","subj":"T150","obj":"org_arg"},{"id":"A205","pred":"EngName","subj":"T150","obj":"MAP4K3"},{"id":"A209","pred":"type","subj":"T152","obj":"Protein"},{"id":"A210","pred":"original paper","subj":"T152","obj":"org_arg"},{"id":"A211","pred":"EngName","subj":"T152","obj":"MAP4K5"},{"id":"A39","pred":"type","subj":"T39","obj":"Protein"},{"id":"A59","pred":"type","subj":"T61","obj":"Protein"},{"id":"A143","pred":"out_of_scope","subj":"T102","obj":"t"},{"id":"A435","pred":"note","subj":"T94","obj":"LATS2"},{"id":"A436","pred":"EngName","subj":"T94","obj":"LATS2"},{"id":"A89","pred":"type","subj":"T91","obj":"Protein"},{"id":"A91","pred":"type","subj":"T94","obj":"Protein"},{"id":"A99","pred":"type","subj":"T102","obj":"Protein"},{"id":"A102","pred":"type","subj":"T105","obj":"Protein"},{"id":"A126","pred":"type","subj":"T129","obj":"Protein"},{"id":"A146","pred":"out_of_scope","subj":"T105","obj":"t"},{"id":"A170","pred":"out_of_scope","subj":"T129","obj":"t"},{"id":"A200","pred":"type","subj":"T149","obj":"Protein"},{"id":"A201","pred":"original paper","subj":"T149","obj":"org_arg"},{"id":"A202","pred":"EngName","subj":"T149","obj":"MAP4K2"},{"id":"A34","pred":"type","subj":"T34","obj":"Protein"},{"id":"A113","pred":"type","subj":"T116","obj":"Protein"},{"id":"A157","pred":"out_of_scope","subj":"T116","obj":"t"},{"id":"A405","pred":"type","subj":"T223","obj":"Protein"},{"id":"A409","pred":"out_of_scope","subj":"T223","obj":"t"},{"id":"A78","pred":"type","subj":"T80","obj":"Protein"},{"id":"A125","pred":"type","subj":"T128","obj":"Protein"},{"id":"A169","pred":"out_of_scope","subj":"T128","obj":"t"},{"id":"A63","pred":"type","subj":"T65","obj":"Protein"},{"id":"A72","pred":"type","subj":"T74","obj":"Protein"},{"id":"A127","pred":"type","subj":"T130","obj":"Protein"},{"id":"A16","pred":"type","subj":"T16","obj":"Protein"},{"id":"A171","pred":"out_of_scope","subj":"T130","obj":"t"},{"id":"A369","pred":"type","subj":"T205","obj":"Protein"},{"id":"A370","pred":"original paper","subj":"T205","obj":"org_arg"},{"id":"A70","pred":"type","subj":"T72","obj":"Protein"},{"id":"A65","pred":"type","subj":"T67","obj":"Protein"},{"id":"A117","pred":"type","subj":"T120","obj":"Protein"},{"id":"A131","pred":"type","subj":"T134","obj":"Protein"},{"id":"A161","pred":"out_of_scope","subj":"T120","obj":"t"},{"id":"A175","pred":"out_of_scope","subj":"T134","obj":"t"},{"id":"A81","pred":"type","subj":"T83","obj":"Protein"},{"id":"A120","pred":"type","subj":"T123","obj":"Protein"},{"id":"A122","pred":"type","subj":"T125","obj":"Protein"},{"id":"A164","pred":"out_of_scope","subj":"T123","obj":"t"},{"id":"A166","pred":"out_of_scope","subj":"T125","obj":"t"},{"id":"A181","pred":"type","subj":"T140","obj":"Protein"},{"id":"A185","pred":"original paper","subj":"T140","obj":"org_arg"},{"id":"A73","pred":"type","subj":"T75","obj":"Protein"},{"id":"A110","pred":"type","subj":"T113","obj":"Protein"},{"id":"A154","pred":"out_of_scope","subj":"T113","obj":"t"},{"id":"A33","pred":"type","subj":"T33","obj":"Protein"},{"id":"A367","pred":"type","subj":"T204","obj":"Protein"},{"id":"A368","pred":"original paper","subj":"T204","obj":"org_arg"},{"id":"A394","pred":"species","subj":"T82","obj":"general"},{"id":"A49","pred":"type","subj":"T51","obj":"Protein"},{"id":"A61","pred":"type","subj":"T63","obj":"Protein"},{"id":"A80","pred":"type","subj":"T82","obj":"Protein"},{"id":"A86","pred":"type","subj":"T88","obj":"Protein"},{"id":"A101","pred":"type","subj":"T104","obj":"Protein"},{"id":"A145","pred":"out_of_scope","subj":"T104","obj":"t"},{"id":"A40","pred":"type","subj":"T40","obj":"Protein"},{"id":"A18","pred":"type","subj":"T18","obj":"Protein"},{"id":"A182","pred":"type","subj":"T141","obj":"Protein"},{"id":"A186","pred":"original paper","subj":"T141","obj":"org_arg"},{"id":"A188","pred":"type","subj":"T143","obj":"Protein"},{"id":"A191","pred":"original paper","subj":"T143","obj":"org_arg"},{"id":"A364","pred":"note","subj":"T141","obj":"refの5自体はhumanなのだが、レビューで\"マウス\"と明記しているので、生物種マウスのIDにしておく。"},{"id":"A55","pred":"type","subj":"T57","obj":"Protein"},{"id":"A11","pred":"type","subj":"T11","obj":"Protein"},{"id":"A114","pred":"type","subj":"T117","obj":"Protein"},{"id":"A158","pred":"out_of_scope","subj":"T117","obj":"t"},{"id":"A22","pred":"type","subj":"T22","obj":"Protein"},{"id":"A25","pred":"type","subj":"T25","obj":"Protein"},{"id":"A82","pred":"type","subj":"T84","obj":"Protein"},{"id":"A1","pred":"type","subj":"T1","obj":"Protein"},{"id":"A137","pred":"out_of_scope","subj":"T96","obj":"t"},{"id":"A32","pred":"type","subj":"T32","obj":"Protein"},{"id":"A93","pred":"type","subj":"T96","obj":"Protein"},{"id":"A180","pred":"type","subj":"T139","obj":"Protein"},{"id":"A184","pred":"original paper","subj":"T139","obj":"org_arg"},{"id":"A356","pred":"type","subj":"T200","obj":"Protein"},{"id":"A357","pred":"species","subj":"T200","obj":"general"},{"id":"A48","pred":"type","subj":"T50","obj":"Protein"},{"id":"A240","pred":"type","subj":"T170","obj":"Protein"},{"id":"A284","pred":"original paper","subj":"T170","obj":"org_arg"},{"id":"A296","pred":"type","subj":"T182","obj":"Protein"},{"id":"A317","pred":"species","subj":"T182","obj":"general"},{"id":"A338","pred":"original paper","subj":"T182","obj":"org_arg"},{"id":"A375","pred":"type","subj":"T208","obj":"Protein"},{"id":"A376","pred":"original paper","subj":"T208","obj":"org_arg"},{"id":"A62","pred":"type","subj":"T64","obj":"Protein"},{"id":"A17","pred":"type","subj":"T17","obj":"Protein"},{"id":"A295","pred":"type","subj":"T181","obj":"Protein"},{"id":"A316","pred":"species","subj":"T181","obj":"general"},{"id":"A337","pred":"original paper","subj":"T181","obj":"org_arg"},{"id":"A421","pred":"type","subj":"T227","obj":"Protein"},{"id":"A422","pred":"original paper","subj":"T227","obj":"org_arg"},{"id":"A67","pred":"type","subj":"T69","obj":"Protein"},{"id":"A121","pred":"type","subj":"T124","obj":"Protein"},{"id":"A14","pred":"type","subj":"T14","obj":"Protein"},{"id":"A165","pred":"out_of_scope","subj":"T124","obj":"t"},{"id":"A30","pred":"type","subj":"T30","obj":"Protein"},{"id":"A397","pred":"type","subj":"T218","obj":"Protein"},{"id":"A400","pred":"out_of_scope","subj":"T218","obj":"t"},{"id":"A29","pred":"type","subj":"T29","obj":"Protein"},{"id":"A429","pred":"type","subj":"T231","obj":"Protein"},{"id":"A430","pred":"original paper","subj":"T231","obj":"org_arg"},{"id":"A293","pred":"type","subj":"T179","obj":"Protein"},{"id":"A314","pred":"species","subj":"T179","obj":"general"},{"id":"A335","pred":"original paper","subj":"T179","obj":"org_arg"},{"id":"A75","pred":"type","subj":"T77","obj":"Protein"},{"subj":"T96","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T48","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T46","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T94","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T95","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T97","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T98","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T3","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T49","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T4","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T50","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T99","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T1","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T51","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T100","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T101","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T102","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T139","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T143","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T146","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T148","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T153","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T152","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T151","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T150","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T149","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T154","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T5","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T52","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T103","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T140","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T144","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T147","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T155","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T156","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T7","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T54","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T104","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T157","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T179","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T158","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T180","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T200","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T201","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T105","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T159","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T181","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T106","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T202","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T203","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T160","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T182","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T107","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T141","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T145","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T161","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T108","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T109","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T10","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T57","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T110","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T111","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T112","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T162","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T183","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T113","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T114","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T115","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T11","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T58","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T204","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T207","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T12","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T59","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T205","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T208","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T206","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T209","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T13","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T60","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T14","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T61","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T211","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T210","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T15","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T62","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T16","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T63","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T17","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T64","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T18","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T65","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T19","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T66","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T116","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T20","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T67","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T21","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T68","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T22","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T69","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T23","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T70","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T212","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T24","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T71","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T25","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T72","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T26","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T73","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T27","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T74","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T28","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T75","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T29","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T76","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T30","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T77","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T167","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T188","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T214","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T216","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T213","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T215","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T31","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T78","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T32","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T79","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T33","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T80","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T34","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T81","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T35","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T82","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T36","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T83","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T217","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T220","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T37","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T84","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T234","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T235","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T218","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T221","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T117","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T118","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T119","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T120","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T121","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T122","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T170","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T191","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T123","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T226","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T229","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T227","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T230","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T124","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T228","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T231","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T125","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T39","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T86","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T126","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T233","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T232","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T127","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T128","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T129","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T40","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T87","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T41","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T88","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T130","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T42","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T89","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T132","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T44","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T90","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T133","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T219","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T222","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T223","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T134","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T135","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T178","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T199","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T136","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T45","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T91","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T137","pred":"source","obj":"FA_Top100Plus-GeneProtein"},{"subj":"T138","pred":"source","obj":"FA_Top100Plus-GeneProtein"}],"namespaces":[{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"PR","uri":"http://purl.obolibrary.org/obo/PR_"},{"prefix":"Gene ID","uri":"https://www.ncbi.nlm.nih.gov/gene/"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"FA_Top107-forWeb","color":"#93ece6","default":true},{"id":"FA_Top100-Disease","color":"#eccc93"},{"id":"FA_Top100Plus-GeneProtein","color":"#b293ec"}]}]}}