| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-59 |
Sentence |
denotes |
Mice lacking the transcription factor CIITA--a second look. |
| S2 |
60-235 |
Sentence |
denotes |
We have generated a second line of mice lacking a transcription factor thought to be a critical regulator of MHC class II gene expression, CIITA (for class II transactivator). |
| S3 |
236-441 |
Sentence |
denotes |
Our and the previously published lines differ in the deletion that was engineered and by the fact that we removed the neomycin-resistance promoter and structural gene via the cre-loxP recombination system. |
| S4 |
442-495 |
Sentence |
denotes |
Characterization of our line led to two new findings. |
| S5 |
496-804 |
Sentence |
denotes |
First, a substantial number of cells can express class II molecules in the absence of CIITA, albeit at 5-fold reduced levels, most notably dendritic cells in s.c. lymph nodes; therefore, the CIITA gene cannot be an absolute 'master gene' controlling the expression of class II molecules, as had been thought. |
| S6 |
805-957 |
Sentence |
denotes |
Second, in contrast to recent results on human cell lines, CIITA is not critically involved in the IFN-gamma-induced up-regulation of MHC class I genes. |
