| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-41 |
Sentence |
denotes |
Immunophenotype of intraductal carcinoma. |
| S2 |
42-248 |
Sentence |
denotes |
OBJECTIVE: Mammography and breast-conserving therapy have focused attention on the classification of intraductal carcinoma (IDC) and emphasized the prognostic importance of comedo versus noncomedo variants. |
| S3 |
249-396 |
Sentence |
denotes |
We used histochemical markers to define the immunophenotype of 43 IDCs with respect to comedo versus noncomedo status and patterns of angiogenesis. |
| S4 |
397-587 |
Sentence |
denotes |
RESULTS: Reactions in comedo carcinomas were significantly negative for estrogen receptor and progesterone receptor, and positive for p53 and HER-2/neu more often than the noncomedo variant. |
| S5 |
588-675 |
Sentence |
denotes |
All seven IDCs associated with Paget's disease showed positive reactions for HER-2/neu. |
| S6 |
676-887 |
Sentence |
denotes |
Basement membrane immunoreactivity for type IV collagen and laminin was discontinuous in most examples of IDC regardless of type, with a trend toward more intense staining in comedo than in noncomedo carcinomas. |
| S7 |
888-1008 |
Sentence |
denotes |
Periductal angiogenesis was not significantly related to the type of IDC but was more pronounced with comedo carcinomas. |
| S8 |
1009-1141 |
Sentence |
denotes |
CONCLUSIONS: These observations indicate that there are immunophenotypic correlates to the current structural classification of IDC. |
| S9 |
1142-1321 |
Sentence |
denotes |
The immunophenotype of IDC is helpful in subclassifying an IDC and could prove useful as a prognostic indicator for local control in patients treated by breast-conserving therapy. |
