| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-60 |
Sentence |
denotes |
Proliferation index as a prognostic marker in breast cancer. |
| S2 |
61-72 |
Sentence |
denotes |
BACKGROUND: |
| S3 |
73-294 |
Sentence |
denotes |
The proliferative activity of tumors has been extensively investigated with different approaches, among which the use of the monoclonal antibody Ki-67 represents an easy and reliable means of assessing cell proliferation. |
| S4 |
295-427 |
Sentence |
denotes |
In this study, the proliferative activity of 129 primary breast cancers was investigated, and the results were related to prognosis. |
| S5 |
428-436 |
Sentence |
denotes |
METHODS: |
| S6 |
437-629 |
Sentence |
denotes |
Tumor samples, obtained from 129 patients who underwent surgery between January 1987 and December 1988, were processed for staining by an immunohistochemical procedure (avidin-biotin complex). |
| S7 |
630-697 |
Sentence |
denotes |
The median time of observation was 42 months (range, 31-55 months). |
| S8 |
698-823 |
Sentence |
denotes |
Life-table analysis (Mantel-Cox) was used to assess the probability of disease-free survival (DFS) and overall survival (OS). |
| S9 |
824-832 |
Sentence |
denotes |
RESULTS: |
| S10 |
833-1079 |
Sentence |
denotes |
Tumors with high Ki-67 proliferation indices (> 20%) were associated with a higher 4-year probability of relapse of disease (55.3% versus 79.1%; P = 0.003) and death (71% versus 95.6%; P = 0.00005) when compared with tumors with low Ki-67 values. |
| S11 |
1080-1289 |
Sentence |
denotes |
In addition, this proliferative parameter maintained its prognostic significance when the patients were stratified according to lymph node involvement, menopausal status, and nuclear estrogen receptor content. |
| S12 |
1290-1302 |
Sentence |
denotes |
CONCLUSIONS: |
| S13 |
1303-1458 |
Sentence |
denotes |
Tumor proliferative activity as evaluated by the monoclonal antibody Ki-67 seems to be an effective indicator of prognosis in breast cancer for DFS and OS. |
