| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-85 |
Sentence |
denotes |
TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia. |
| S2 |
86-331 |
Sentence |
denotes |
The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1)] and inversions [inv14(q11;q32.1)] with TCR alpha/beta loci in T-cell leukemias, such as T-prolymphocytic (T-PLL). |
| S3 |
332-463 |
Sentence |
denotes |
It is also involved in T-acute and -chronic leukemias arising in cases of ataxia-telangiectasia (AT), an immunodeficiency syndrome. |
| S4 |
464-602 |
Sentence |
denotes |
Similar chromosomal rearrangements occur also in the clonally expanded T cells in AT patients before the appearance of the overt leukemia. |
| S5 |
603-744 |
Sentence |
denotes |
We have analyzed the expression of TCL1 mRNA and protein in peripheral blood lymphocytes (PBLs) from four AT cases and from healthy controls. |
| S6 |
745-942 |
Sentence |
denotes |
We found that the TCL1 gene was overexpressed in the PBLs of an AT patient with a large clonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases. |
| S7 |
943-1248 |
Sentence |
denotes |
Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the distal part of chromosome 14. |
| S8 |
1249-1413 |
Sentence |
denotes |
These data indicate that TCL1 is activated in preleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at 14q11. |
| S9 |
1414-1570 |
Sentence |
denotes |
Deregulation of TCL1 is the first event in the initiation of malignancy in these types of leukemias and represents a potential tool for clinical evaluation. |
