| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-113 |
Sentence |
denotes |
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. |
| S2 |
114-203 |
Sentence |
denotes |
Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. |
| S3 |
204-385 |
Sentence |
denotes |
They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear. |
| S4 |
386-523 |
Sentence |
denotes |
Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B (NF-kappa B) activation in mice and cultured cells. |
| S5 |
524-675 |
Sentence |
denotes |
This inhibition is mediated by induction of the I kappa B alpha inhibitory protein, which traps activated NF-kappa B in inactive cytoplasmic complexes. |
| S6 |
676-883 |
Sentence |
denotes |
Because NF-kappa B activates many immunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids. |
