| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-132 |
Sentence |
denotes |
Inducible binding to the c-fos serum response element during T cell activation is regulated by a phosphotyrosine-containing protein. |
| S2 |
133-283 |
Sentence |
denotes |
The proto-oncogene c-fos is an immediate-early gene, and one of the first genes transcribed after stimulation of most cells with a variety of ligands. |
| S3 |
284-426 |
Sentence |
denotes |
Fos expression may be a pivotal event in converting ligand-receptor interactions at the membrane into functional modulation of cell phenotype. |
| S4 |
427-625 |
Sentence |
denotes |
The serum response element (SRE) in the c-fos regulatory region participates in induction of transcription by various growth factors and by phorbol esters and subsequent squelching of transcription. |
| S5 |
626-788 |
Sentence |
denotes |
We show that an inducible protein complex (Band A) binds to SRE DNA within 10 min after mitogenic stimulation of human PBL-T, and becomes nondetectable by 60 min. |
| S6 |
789-857 |
Sentence |
denotes |
Band A contains the serum response factor plus additional factor(s). |
| S7 |
858-991 |
Sentence |
denotes |
A protein that is phosphorylated on a tyrosine residue in resting PBL-T suppresses binding of a component of Band A to the SRE motif. |
| S8 |
992-1134 |
Sentence |
denotes |
Upon stimulation of the cells, this protein no longer prevents binding of DNA by Band A, and suppression of binding is restored within 30 min. |
| S9 |
1135-1227 |
Sentence |
denotes |
The phosphorylated tyrosine residue itself is important for the protein-protein interaction. |
