| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-68 |
Sentence |
denotes |
The role of gamma/delta T cell receptor positive cells in pregnancy. |
| S2 |
69-241 |
Sentence |
denotes |
PROBLEM: Due to the lack of classical HLA antigens on the trophoblast, fetal antigens are possibly presented in a non major histocompatibility complex (MHC) restricted way. |
| S3 |
242-449 |
Sentence |
denotes |
Decidual gammadelta T cells, which significantly increase in number during pregnancy, might play a role in recognition of fetal antigens and also in determining the quality of the response to these antigens. |
| S4 |
450-563 |
Sentence |
denotes |
Our study was aimed at investigating the role of this cell population in progesterone-dependent immunomodulation. |
| S5 |
564-774 |
Sentence |
denotes |
METHOD OF STUDY: Peripheral lymphocytes from healthy pregnant women and from habitual aborters were tested by immunocytochemistry for the presence of gamma/delta T cell receptor (TCR) and progesterone receptor. |
| S6 |
775-1089 |
Sentence |
denotes |
To investigate the effect of treatment with a pan anti gamma/delta antibody, lymphocytes were incubated for 3 hr with the antibody, and then interleukin (IL)-10, IL-12 and progesterone-induced blocking factor (PIBF) expression (by immuno-cytochemistry) as well as natural killer (NK) cell activity were determined. |
| S7 |
1090-1289 |
Sentence |
denotes |
RESULTS: In peripheral blood of healthy pregnant women the percentage of gamma/delta TCR+ cells was significantly higher (P < 0.001) than in that of recurrent aborters or of non-pregnant individuals. |
| S8 |
1290-1385 |
Sentence |
denotes |
Ninety-seven percent of gamma/delta TCR+ pregnancy lymphocytes expressed progesterone receptor. |
| S9 |
1386-1539 |
Sentence |
denotes |
Binding of a specific antibody to the gamma/delta TCR inhibited PIBF- as well as IL-10 production, whereas it increased NK activity and IL-12 expression. |
| S10 |
1540-1663 |
Sentence |
denotes |
CONCLUSIONS: These data suggest the role of gamma/delta TCR-bearing lymphocytes in progesterone-dependent immunomodulation. |
