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PMC:523229 / 47901-49660 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T10586 0-4 NN denotes Lack
T10588 5-7 IN denotes of
T10589 8-14 NN denotes Bmpr1a
T10590 15-23 NN denotes function
T10591 24-26 IN denotes in
T10592 27-36 JJ denotes articular
T10593 37-46 NN denotes cartilage
T10587 47-54 VBZ denotes results
T10594 55-57 IN denotes in
T10595 58-64 JJ denotes severe
T10596 65-77 NN denotes fibrillation
T10597 78-80 IN denotes of
T10598 81-84 DT denotes the
T10600 85-94 JJ denotes articular
T10599 95-102 NN denotes surface
T10601 103-106 CC denotes and
T10602 107-111 NN denotes loss
T10603 112-114 IN denotes of
T10604 115-120 NN denotes joint
T10605 121-129 NN denotes mobility
T10606 129-130 . denotes .
T10607 130-293 sentence denotes The development of severe arthritis symptoms in Bmpr1a-deficient mice raises the possibility that defects in BMP signaling also contribute to human joint disease.
T10608 131-134 DT denotes The
T10609 135-146 NN denotes development
T10611 147-149 IN denotes of
T10612 150-156 JJ denotes severe
T10614 157-166 NN denotes arthritis
T10613 167-175 NNS denotes symptoms
T10615 176-178 IN denotes in
T10616 179-185 NN denotes Bmpr1a
T10618 185-186 HYPH denotes -
T10617 186-195 JJ denotes deficient
T10619 196-200 NNS denotes mice
T10610 201-207 VBZ denotes raises
T10620 208-211 DT denotes the
T10621 212-223 NN denotes possibility
T10622 224-228 IN denotes that
T10624 229-236 NNS denotes defects
T10625 237-239 IN denotes in
T10626 240-243 NN denotes BMP
T10627 244-253 NN denotes signaling
T10628 254-258 RB denotes also
T10623 259-269 VBP denotes contribute
T10629 270-272 IN denotes to
T10630 273-278 JJ denotes human
T10632 279-284 NN denotes joint
T10631 285-292 NN denotes disease
T10633 292-293 . denotes .
T10634 293-506 sentence denotes Osteoarthritis is known to have a significant genetic component, but it likely involves multiple genetic factors that have been difficult to identify (Spector et al. 1996; Felson et al. 1998; Hirsch et al. 1998).
T10635 294-308 NN denotes Osteoarthritis
T10637 309-311 VBZ denotes is
T10636 312-317 VBN denotes known
T10638 318-320 TO denotes to
T10639 321-325 VB denotes have
T10640 326-327 DT denotes a
T10642 328-339 JJ denotes significant
T10643 340-347 JJ denotes genetic
T10641 348-357 NN denotes component
T10644 357-359 , denotes ,
T10645 359-362 CC denotes but
T10646 363-365 PRP denotes it
T10648 366-372 RB denotes likely
T10647 373-381 VBZ denotes involves
T10649 382-390 JJ denotes multiple
T10651 391-398 JJ denotes genetic
T10650 399-406 NNS denotes factors
T10652 407-411 WDT denotes that
T10654 412-416 VBP denotes have
T10653 417-421 VBN denotes been
T10655 422-431 JJ denotes difficult
T10656 432-434 TO denotes to
T10657 435-443 VB denotes identify
T10658 444-445 -LRB- denotes (
T10659 445-452 NNP denotes Spector
T10660 453-455 FW denotes et
T10661 456-459 FW denotes al.
T10662 460-464 CD denotes 1996
T10663 464-465 : denotes ;
T10664 466-472 NNP denotes Felson
T10665 473-475 FW denotes et
T10666 476-479 FW denotes al.
T10667 480-484 CD denotes 1998
T10668 484-485 : denotes ;
T10669 486-492 NNP denotes Hirsch
T10670 493-495 FW denotes et
T10671 496-499 FW denotes al.
T10672 500-504 CD denotes 1998
T10673 504-505 -RRB- denotes )
T10674 505-506 . denotes .
T10675 506-732 sentence denotes Humans that are heterozygous for loss-of-function mutations in BMPR1A are known to be at risk for juvenile polyposis (Howe et al. 2001; Zhou et al. 2001), but the risk of osteoarthritis for these people has not been reported.
T10676 507-513 NNS denotes Humans
T10678 514-518 WDT denotes that
T10679 519-522 VBP denotes are
T10680 523-535 JJ denotes heterozygous
T10681 536-539 IN denotes for
T10682 540-544 NN denotes loss
T10684 544-545 HYPH denotes -
T10685 545-547 IN denotes of
T10686 547-548 HYPH denotes -
T10687 548-556 NN denotes function
T10683 557-566 NNS denotes mutations
T10688 567-569 IN denotes in
T10689 570-576 NN denotes BMPR1A
T10690 577-580 VBP denotes are
T10677 581-586 VBN denotes known
T10691 587-589 TO denotes to
T10692 590-592 VB denotes be
T10693 593-595 IN denotes at
T10694 596-600 NN denotes risk
T10695 601-604 IN denotes for
T10696 605-613 JJ denotes juvenile
T10697 614-623 NN denotes polyposis
T10698 624-625 -LRB- denotes (
T10699 625-629 NNP denotes Howe
T10700 630-632 FW denotes et
T10701 633-636 FW denotes al.
T10702 637-641 CD denotes 2001
T10703 641-642 : denotes ;
T10704 643-647 NNP denotes Zhou
T10705 648-650 FW denotes et
T10706 651-654 FW denotes al.
T10707 655-659 CD denotes 2001
T10708 659-660 -RRB- denotes )
T10709 660-662 , denotes ,
T10710 662-665 CC denotes but
T10711 666-669 DT denotes the
T10712 670-674 NN denotes risk
T10714 675-677 IN denotes of
T10715 678-692 NN denotes osteoarthritis
T10716 693-696 IN denotes for
T10717 697-702 DT denotes these
T10718 703-709 NNS denotes people
T10719 710-713 VBZ denotes has
T10720 714-717 RB denotes not
T10721 718-722 VBN denotes been
T10713 723-731 VBN denotes reported
T10722 731-732 . denotes .
T10723 732-889 sentence denotes However, the control mice used in this study were heterozygous for a null allele of Bmpr1a, and they showed little sign of osteoarthritis even late in life.
T10724 733-740 RB denotes However
T10726 740-742 , denotes ,
T10727 742-745 DT denotes the
T10729 746-753 NN denotes control
T10728 754-758 NNS denotes mice
T10730 759-763 VBN denotes used
T10731 764-766 IN denotes in
T10732 767-771 DT denotes this
T10733 772-777 NN denotes study
T10725 778-782 VBD denotes were
T10734 783-795 JJ denotes heterozygous
T10735 796-799 IN denotes for
T10736 800-801 DT denotes a
T10738 802-806 JJ denotes null
T10737 807-813 NN denotes allele
T10739 814-816 IN denotes of
T10740 817-823 NN denotes Bmpr1a
T10741 823-825 , denotes ,
T10742 825-828 CC denotes and
T10743 829-833 PRP denotes they
T10744 834-840 VBD denotes showed
T10745 841-847 JJ denotes little
T10746 848-852 NN denotes sign
T10747 853-855 IN denotes of
T10748 856-870 NN denotes osteoarthritis
T10749 871-875 RB denotes even
T10750 876-880 RB denotes late
T10751 881-883 IN denotes in
T10752 884-888 NN denotes life
T10753 888-889 . denotes .
T10754 889-1058 sentence denotes Several chromosome regions have been previously linked to arthritis phenotypes in humans using either association studies in populations or linkage studies in families.
T10755 890-897 JJ denotes Several
T10757 898-908 NN denotes chromosome
T10756 909-916 NNS denotes regions
T10759 917-921 VBP denotes have
T10760 922-926 VBN denotes been
T10761 927-937 RB denotes previously
T10758 938-944 VBN denotes linked
T10762 945-947 IN denotes to
T10763 948-957 NN denotes arthritis
T10764 958-968 NNS denotes phenotypes
T10765 969-971 IN denotes in
T10766 972-978 NNS denotes humans
T10767 979-984 VBG denotes using
T10768 985-991 CC denotes either
T10770 992-1003 NN denotes association
T10769 1004-1011 NNS denotes studies
T10771 1012-1014 IN denotes in
T10772 1015-1026 NNS denotes populations
T10773 1027-1029 CC denotes or
T10774 1030-1037 NN denotes linkage
T10775 1038-1045 NNS denotes studies
T10776 1046-1048 IN denotes in
T10777 1049-1057 NNS denotes families
T10778 1057-1058 . denotes .
T10779 1058-1428 sentence denotes It is interesting to note that several of these chromosome regions contain genes encoding different members of the BMP signaling pathway, including the BMP5 gene on human chromosome 6p12 (Loughlin et al. 2002), the MADH1 gene on human chromosome 4q26–4q31 (Leppavuori et al. 1999; Kent et al. 2002), and the BMPR2 receptor on human chromosome 2q33 (Wright et al. 1996).
T10780 1059-1061 PRP denotes It
T10781 1062-1064 VBZ denotes is
T10782 1065-1076 JJ denotes interesting
T10783 1077-1079 TO denotes to
T10784 1080-1084 VB denotes note
T10785 1085-1089 IN denotes that
T10787 1090-1097 JJ denotes several
T10788 1098-1100 IN denotes of
T10789 1101-1106 DT denotes these
T10791 1107-1117 NN denotes chromosome
T10790 1118-1125 NNS denotes regions
T10786 1126-1133 VBP denotes contain
T10792 1134-1139 NNS denotes genes
T10793 1140-1148 VBG denotes encoding
T10794 1149-1158 JJ denotes different
T10795 1159-1166 NNS denotes members
T10796 1167-1169 IN denotes of
T10797 1170-1173 DT denotes the
T10799 1174-1177 NN denotes BMP
T10800 1178-1187 NN denotes signaling
T10798 1188-1195 NN denotes pathway
T10801 1195-1197 , denotes ,
T10802 1197-1206 VBG denotes including
T10803 1207-1210 DT denotes the
T10805 1211-1215 NN denotes BMP5
T10804 1216-1220 NN denotes gene
T10806 1221-1223 IN denotes on
T10807 1224-1229 JJ denotes human
T10809 1230-1240 NN denotes chromosome
T10808 1241-1245 NN denotes 6p12
T10810 1246-1247 -LRB- denotes (
T10811 1247-1255 NNP denotes Loughlin
T10812 1256-1258 FW denotes et
T10813 1259-1262 FW denotes al.
T10814 1263-1267 CD denotes 2002
T10815 1267-1268 -RRB- denotes )
T10816 1268-1270 , denotes ,
T10817 1270-1273 DT denotes the
T10819 1274-1279 NN denotes MADH1
T10818 1280-1284 NN denotes gene
T10820 1285-1287 IN denotes on
T10821 1288-1293 JJ denotes human
T10823 1294-1304 NN denotes chromosome
T10822 1305-1309 NN denotes 4q26
T10824 1309-1310 SYM denotes –
T10825 1310-1314 NN denotes 4q31
T10826 1315-1316 -LRB- denotes (
T10827 1316-1326 NNP denotes Leppavuori
T10828 1327-1329 FW denotes et
T10829 1330-1333 FW denotes al.
T10830 1334-1338 CD denotes 1999
T10831 1338-1339 : denotes ;
T10832 1340-1344 NNP denotes Kent
T10833 1345-1347 FW denotes et
T10834 1348-1351 FW denotes al.
T10835 1352-1356 CD denotes 2002
T10836 1356-1357 -RRB- denotes )
T10837 1357-1359 , denotes ,
T10838 1359-1362 CC denotes and
T10839 1363-1366 DT denotes the
T10841 1367-1372 NN denotes BMPR2
T10840 1373-1381 NN denotes receptor
T10842 1382-1384 IN denotes on
T10843 1385-1390 JJ denotes human
T10845 1391-1401 NN denotes chromosome
T10844 1402-1406 NN denotes 2q33
T10846 1407-1408 -LRB- denotes (
T10847 1408-1414 NNP denotes Wright
T10848 1415-1417 FW denotes et
T10849 1418-1421 FW denotes al.
T10850 1422-1426 CD denotes 1996
T10851 1426-1427 -RRB- denotes )
T10852 1427-1428 . denotes .
T10853 1428-1581 sentence denotes The complex nature of human osteoarthritis suggests that interactions between multiple genes may be involved in modifying susceptibility to the disease.
T10854 1429-1432 DT denotes The
T10856 1433-1440 JJ denotes complex
T10855 1441-1447 NN denotes nature
T10858 1448-1450 IN denotes of
T10859 1451-1456 JJ denotes human
T10860 1457-1471 NN denotes osteoarthritis
T10857 1472-1480 VBZ denotes suggests
T10861 1481-1485 IN denotes that
T10863 1486-1498 NNS denotes interactions
T10864 1499-1506 IN denotes between
T10865 1507-1515 JJ denotes multiple
T10866 1516-1521 NNS denotes genes
T10867 1522-1525 MD denotes may
T10868 1526-1528 VB denotes be
T10862 1529-1537 VBN denotes involved
T10869 1538-1540 IN denotes in
T10870 1541-1550 VBG denotes modifying
T10871 1551-1565 NN denotes susceptibility
T10872 1566-1568 IN denotes to
T10873 1569-1572 DT denotes the
T10874 1573-1580 NN denotes disease
T10875 1580-1581 . denotes .
T10876 1581-1759 sentence denotes The inclusion of genetic markers near BMP signaling components may help identify additional osteoarthritis susceptibility loci and facilitate the search for causative mutations.
T10877 1582-1585 DT denotes The
T10878 1586-1595 NN denotes inclusion
T10880 1596-1598 IN denotes of
T10881 1599-1606 JJ denotes genetic
T10882 1607-1614 NNS denotes markers
T10883 1615-1619 IN denotes near
T10884 1620-1623 NN denotes BMP
T10886 1624-1633 NN denotes signaling
T10885 1634-1644 NNS denotes components
T10887 1645-1648 MD denotes may
T10879 1649-1653 VB denotes help
T10888 1654-1662 VB denotes identify
T10889 1663-1673 JJ denotes additional
T10891 1674-1688 NN denotes osteoarthritis
T10892 1689-1703 NN denotes susceptibility
T10890 1704-1708 NNS denotes loci
T10893 1709-1712 CC denotes and
T10894 1713-1723 VB denotes facilitate
T10895 1724-1727 DT denotes the
T10896 1728-1734 NN denotes search
T10897 1735-1738 IN denotes for
T10898 1739-1748 JJ denotes causative
T10899 1749-1758 NNS denotes mutations
T10900 1758-1759 . denotes .
R6818 T10586 T10587 nsubj Lack,results
R6820 T10588 T10586 prep of,Lack
R6821 T10589 T10590 compound Bmpr1a,function
R6822 T10590 T10588 pobj function,of
R6824 T10591 T10590 prep in,function
R6825 T10592 T10593 amod articular,cartilage
R6827 T10593 T10591 pobj cartilage,in
R6829 T10594 T10587 prep in,results
R6830 T10595 T10596 amod severe,fibrillation
R6831 T10596 T10594 pobj fibrillation,in
R6832 T10597 T10596 prep of,fibrillation
R6833 T10627 T10625 pobj signaling,in
R6834 T10598 T10599 det the,surface
R6835 T10628 T10623 advmod also,contribute
R6836 T10599 T10597 pobj surface,of
R6837 T10600 T10599 amod articular,surface
R6838 T10601 T10596 cc and,fibrillation
R6839 T10629 T10623 prep to,contribute
R6840 T10602 T10596 conj loss,fibrillation
R6841 T10603 T10602 prep of,loss
R6842 T10630 T10631 amod human,disease
R6843 T10604 T10605 compound joint,mobility
R6844 T10605 T10603 pobj mobility,of
R6845 T10606 T10587 punct .,results
R6846 T10631 T10629 pobj disease,to
R6847 T10608 T10609 det The,development
R6848 T10609 T10610 nsubj development,raises
R6849 T10632 T10631 compound joint,disease
R6850 T10633 T10610 punct .,raises
R6851 T10611 T10609 prep of,development
R6852 T10635 T10636 nsubjpass Osteoarthritis,known
R6853 T10612 T10613 amod severe,symptoms
R6854 T10613 T10611 pobj symptoms,of
R6855 T10614 T10613 compound arthritis,symptoms
R6856 T10615 T10609 prep in,development
R6857 T10637 T10636 auxpass is,known
R6858 T10616 T10617 npadvmod Bmpr1a,deficient
R6859 T10617 T10619 amod deficient,mice
R6860 T10618 T10617 punct -,deficient
R6861 T10619 T10615 pobj mice,in
R6862 T10620 T10621 det the,possibility
R6863 T10621 T10610 dobj possibility,raises
R6864 T10638 T10639 aux to,have
R6865 T10639 T10636 xcomp have,known
R6866 T10622 T10623 mark that,contribute
R6867 T10640 T10641 det a,component
R6868 T10623 T10621 acl contribute,possibility
R6869 T10624 T10623 nsubj defects,contribute
R6870 T10641 T10639 dobj component,have
R6871 T10625 T10624 prep in,defects
R6872 T10626 T10627 compound BMP,signaling
R6873 T10642 T10641 amod significant,component
R6874 T10643 T10641 amod genetic,component
R6875 T10644 T10636 punct ", ",known
R6876 T10645 T10636 cc but,known
R6877 T10733 T10731 pobj study,in
R6878 T10646 T10647 nsubj it,involves
R6879 T10734 T10725 acomp heterozygous,were
R6880 T10735 T10734 prep for,heterozygous
R6881 T10647 T10636 conj involves,known
R6882 T10736 T10737 det a,allele
R6883 T10737 T10735 pobj allele,for
R6884 T10738 T10737 amod null,allele
R6885 T10648 T10647 advmod likely,involves
R6886 T10739 T10737 prep of,allele
R6887 T10740 T10739 pobj Bmpr1a,of
R6888 T10741 T10725 punct ", ",were
R6889 T10649 T10650 amod multiple,factors
R6890 T10742 T10725 cc and,were
R6891 T10743 T10744 nsubj they,showed
R6892 T10744 T10725 conj showed,were
R6893 T10650 T10647 dobj factors,involves
R6894 T10745 T10746 amod little,sign
R6895 T10746 T10744 dobj sign,showed
R6896 T10651 T10650 amod genetic,factors
R6897 T10747 T10746 prep of,sign
R6898 T10748 T10747 pobj osteoarthritis,of
R6899 T10749 T10750 advmod even,late
R6900 T10652 T10653 dep that,been
R6901 T10750 T10744 advmod late,showed
R6902 T10751 T10750 prep in,late
R6903 T10752 T10751 pobj life,in
R6904 T10653 T10650 relcl been,factors
R6905 T10753 T10744 punct .,showed
R6906 T10654 T10653 aux have,been
R6907 T10755 T10756 amod Several,regions
R6908 T10756 T10758 nsubjpass regions,linked
R6909 T10757 T10756 compound chromosome,regions
R6910 T10655 T10653 acomp difficult,been
R6911 T10759 T10758 aux have,linked
R6912 T10760 T10758 auxpass been,linked
R6913 T10761 T10758 advmod previously,linked
R6914 T10762 T10758 prep to,linked
R6915 T10763 T10764 compound arthritis,phenotypes
R6916 T10656 T10657 aux to,identify
R6917 T10764 T10762 pobj phenotypes,to
R6918 T10765 T10758 prep in,linked
R6919 T10766 T10765 pobj humans,in
R6920 T10657 T10655 advcl identify,difficult
R6921 T10767 T10758 advcl using,linked
R6922 T10768 T10769 preconj either,studies
R6923 T10769 T10767 dobj studies,using
R6924 T10658 T10659 punct (,Spector
R6925 T10770 T10769 compound association,studies
R6926 T10771 T10769 prep in,studies
R6927 T10772 T10771 pobj populations,in
R6928 T10659 T10647 meta Spector,involves
R6929 T10773 T10769 cc or,studies
R6930 T10774 T10775 compound linkage,studies
R6931 T10775 T10769 conj studies,studies
R6932 T10660 T10659 nmod et,Spector
R6933 T10776 T10775 prep in,studies
R6934 T10777 T10776 pobj families,in
R6935 T10778 T10758 punct .,linked
R6936 T10661 T10659 nmod al.,Spector
R6937 T10780 T10781 nsubj It,is
R6938 T10662 T10659 nummod 1996,Spector
R6939 T10782 T10781 acomp interesting,is
R6940 T10663 T10659 punct ;,Spector
R6941 T10783 T10784 aux to,note
R6942 T10664 T10659 nmod Felson,Spector
R6943 T10784 T10781 xcomp note,is
R6944 T10665 T10659 nmod et,Spector
R6945 T10785 T10786 mark that,contain
R6946 T10786 T10784 ccomp contain,note
R6947 T10787 T10786 nsubj several,contain
R6948 T10788 T10787 prep of,several
R6949 T10666 T10659 nmod al.,Spector
R6950 T10789 T10790 det these,regions
R6951 T10790 T10788 pobj regions,of
R6952 T10791 T10790 compound chromosome,regions
R6953 T10667 T10659 nummod 1998,Spector
R6954 T10792 T10786 dobj genes,contain
R6955 T10793 T10792 acl encoding,genes
R6956 T10668 T10659 punct ;,Spector
R6957 T10794 T10795 amod different,members
R6958 T10795 T10793 dobj members,encoding
R6959 T10669 T10659 nmod Hirsch,Spector
R6960 T10796 T10795 prep of,members
R6961 T10797 T10798 det the,pathway
R6962 T10798 T10796 pobj pathway,of
R6963 T10670 T10659 nmod et,Spector
R6964 T10799 T10800 compound BMP,signaling
R6965 T10800 T10798 compound signaling,pathway
R6966 T10801 T10792 punct ", ",genes
R6967 T10802 T10792 prep including,genes
R6968 T10803 T10804 det the,gene
R6969 T10804 T10802 pobj gene,including
R6970 T10671 T10659 nmod al.,Spector
R6971 T10805 T10804 compound BMP5,gene
R6972 T10806 T10804 prep on,gene
R6973 T10807 T10808 amod human,6p12
R6974 T10672 T10659 nummod 1998,Spector
R6975 T10808 T10806 pobj 6p12,on
R6976 T10809 T10808 compound chromosome,6p12
R6977 T10810 T10811 punct (,Loughlin
R6978 T10673 T10659 punct ),Spector
R6979 T10811 T10804 meta Loughlin,gene
R6980 T10812 T10811 nmod et,Loughlin
R6981 T10674 T10647 punct .,involves
R6982 T10813 T10811 nmod al.,Loughlin
R6983 T10814 T10811 nummod 2002,Loughlin
R6984 T10815 T10811 punct ),Loughlin
R6985 T10676 T10677 nsubjpass Humans,known
R6986 T10816 T10804 punct ", ",gene
R6987 T10817 T10818 det the,gene
R6988 T10818 T10804 conj gene,gene
R6989 T10819 T10818 compound MADH1,gene
R6990 T10820 T10818 prep on,gene
R6991 T10678 T10679 dep that,are
R6992 T10821 T10822 amod human,4q26
R6993 T10822 T10820 pobj 4q26,on
R6994 T10823 T10822 compound chromosome,4q26
R6995 T10824 T10825 punct –,4q31
R6996 T10679 T10676 relcl are,Humans
R6997 T10825 T10822 prep 4q31,4q26
R6998 T10680 T10679 acomp heterozygous,are
R6999 T10826 T10827 punct (,Leppavuori
R7000 T10827 T10818 meta Leppavuori,gene
R7001 T10828 T10827 nmod et,Leppavuori
R7002 T10829 T10827 nmod al.,Leppavuori
R7003 T10681 T10680 prep for,heterozygous
R7004 T10830 T10827 nummod 1999,Leppavuori
R7005 T10831 T10827 punct ;,Leppavuori
R7006 T10682 T10683 nmod loss,mutations
R7007 T10832 T10827 nmod Kent,Leppavuori
R7008 T10833 T10827 nmod et,Leppavuori
R7009 T10834 T10827 nmod al.,Leppavuori
R7010 T10683 T10681 pobj mutations,for
R7011 T10835 T10827 nummod 2002,Leppavuori
R7012 T10836 T10827 punct ),Leppavuori
R7013 T10837 T10818 punct ", ",gene
R7014 T10684 T10682 punct -,loss
R7015 T10838 T10818 cc and,gene
R7016 T10685 T10682 prep of,loss
R7017 T10686 T10685 punct -,of
R7018 T10687 T10685 pobj function,of
R7019 T10839 T10840 det the,receptor
R7020 T10688 T10683 prep in,mutations
R7021 T10840 T10818 conj receptor,gene
R7022 T10841 T10840 compound BMPR2,receptor
R7023 T10842 T10840 prep on,receptor
R7024 T10689 T10688 pobj BMPR1A,in
R7025 T10843 T10844 amod human,2q33
R7026 T10844 T10842 pobj 2q33,on
R7027 T10845 T10844 compound chromosome,2q33
R7028 T10690 T10677 auxpass are,known
R7029 T10846 T10847 punct (,Wright
R7030 T10847 T10840 meta Wright,receptor
R7031 T10848 T10847 nmod et,Wright
R7032 T10691 T10692 aux to,be
R7033 T10849 T10847 nmod al.,Wright
R7034 T10850 T10847 nummod 1996,Wright
R7035 T10851 T10847 punct ),Wright
R7036 T10692 T10677 xcomp be,known
R7037 T10852 T10781 punct .,is
R7038 T10854 T10855 det The,nature
R7039 T10693 T10692 prep at,be
R7040 T10855 T10857 nsubj nature,suggests
R7041 T10856 T10855 amod complex,nature
R7042 T10694 T10693 pobj risk,at
R7043 T10858 T10855 prep of,nature
R7044 T10695 T10694 prep for,risk
R7045 T10859 T10860 amod human,osteoarthritis
R7046 T10860 T10858 pobj osteoarthritis,of
R7047 T10861 T10862 mark that,involved
R7048 T10696 T10697 amod juvenile,polyposis
R7049 T10697 T10695 pobj polyposis,for
R7050 T10862 T10857 ccomp involved,suggests
R7051 T10698 T10699 punct (,Howe
R7052 T10863 T10862 nsubjpass interactions,involved
R7053 T10864 T10863 prep between,interactions
R7054 T10865 T10866 amod multiple,genes
R7055 T10699 T10677 meta Howe,known
R7056 T10866 T10864 pobj genes,between
R7057 T10867 T10862 aux may,involved
R7058 T10868 T10862 auxpass be,involved
R7059 T10700 T10699 nmod et,Howe
R7060 T10869 T10862 prep in,involved
R7061 T10870 T10869 pcomp modifying,in
R7062 T10701 T10699 nmod al.,Howe
R7063 T10871 T10870 dobj susceptibility,modifying
R7064 T10872 T10871 prep to,susceptibility
R7065 T10873 T10874 det the,disease
R7066 T10702 T10699 nummod 2001,Howe
R7067 T10874 T10872 pobj disease,to
R7068 T10875 T10857 punct .,suggests
R7069 T10877 T10878 det The,inclusion
R7070 T10878 T10879 nsubj inclusion,help
R7071 T10703 T10699 punct ;,Howe
R7072 T10880 T10878 prep of,inclusion
R7073 T10881 T10882 amod genetic,markers
R7074 T10704 T10699 nmod Zhou,Howe
R7075 T10882 T10880 pobj markers,of
R7076 T10883 T10882 prep near,markers
R7077 T10884 T10885 compound BMP,components
R7078 T10705 T10699 nmod et,Howe
R7079 T10885 T10883 pobj components,near
R7080 T10886 T10885 compound signaling,components
R7081 T10887 T10879 aux may,help
R7082 T10706 T10699 nmod al.,Howe
R7083 T10888 T10879 xcomp identify,help
R7084 T10889 T10890 amod additional,loci
R7085 T10890 T10888 dobj loci,identify
R7086 T10707 T10699 nummod 2001,Howe
R7087 T10891 T10892 compound osteoarthritis,susceptibility
R7088 T10892 T10890 compound susceptibility,loci
R7089 T10708 T10699 punct ),Howe
R7090 T10893 T10888 cc and,identify
R7091 T10894 T10888 conj facilitate,identify
R7092 T10895 T10896 det the,search
R7093 T10709 T10677 punct ", ",known
R7094 T10896 T10894 dobj search,facilitate
R7095 T10897 T10896 prep for,search
R7096 T10898 T10899 amod causative,mutations
R7097 T10710 T10677 cc but,known
R7098 T10899 T10897 pobj mutations,for
R7099 T10900 T10879 punct .,help
R7100 T10711 T10712 det the,risk
R7103 T10712 T10713 nsubjpass risk,reported
R7106 T10713 T10677 conj reported,known
R7109 T10714 T10712 prep of,risk
R7113 T10715 T10714 pobj osteoarthritis,of
R7116 T10716 T10712 prep for,risk
R7124 T10717 T10718 det these,people
R7128 T10718 T10716 pobj people,for
R7132 T10719 T10713 aux has,reported
R7136 T10720 T10713 neg not,reported
R7138 T10721 T10713 auxpass been,reported
R7142 T10722 T10713 punct .,reported
R7145 T10724 T10725 advmod However,were
R7150 T10726 T10725 punct ", ",were
R7154 T10727 T10728 det the,mice
R7155 T10728 T10725 nsubj mice,were
R7156 T10729 T10728 compound control,mice
R7158 T10730 T10728 acl used,mice
R7162 T10731 T10730 prep in,used
R7165 T10732 T10733 det this,study