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PMC:1617083 / 78-2569 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1017 0-10 sentence denotes Background
T1018 0-10 NN denotes Background
T1019 10-155 sentence denotes Thrombosis is the fatal and disabling consequence of cardiovascular diseases, the leading cause of mortality and morbidity in Western countries.
T1020 11-21 NN denotes Thrombosis
T1021 22-24 VBZ denotes is
T1022 25-28 DT denotes the
T1024 29-34 JJ denotes fatal
T1025 35-38 CC denotes and
T1026 39-48 VBG denotes disabling
T1023 49-60 NN denotes consequence
T1027 61-63 IN denotes of
T1028 64-78 JJ denotes cardiovascular
T1029 79-87 NNS denotes diseases
T1030 87-89 , denotes ,
T1031 89-92 DT denotes the
T1033 93-100 VBG denotes leading
T1032 101-106 NN denotes cause
T1034 107-109 IN denotes of
T1035 110-119 NN denotes mortality
T1036 120-123 CC denotes and
T1037 124-133 NN denotes morbidity
T1038 134-136 IN denotes in
T1039 137-144 JJ denotes Western
T1040 145-154 NNS denotes countries
T1041 154-155 . denotes .
T1042 155-293 sentence denotes Two inbred mouse strains, C57BL/6J and A/J, have marked differences in susceptibility to obesity, atherosclerosis, and vessel remodeling.
T1043 156-159 CD denotes Two
T1045 160-166 JJ denotes inbred
T1046 167-172 NN denotes mouse
T1044 173-180 NNS denotes strains
T1048 180-182 , denotes ,
T1049 182-187 NN denotes C57BL
T1051 187-188 HYPH denotes /
T1050 188-190 NN denotes 6J
T1052 191-194 CC denotes and
T1053 195-196 NN denotes A
T1055 196-197 HYPH denotes /
T1054 197-198 NN denotes J
T1056 198-200 , denotes ,
T1047 200-204 VBP denotes have
T1057 205-211 JJ denotes marked
T1058 212-223 NNS denotes differences
T1059 224-226 IN denotes in
T1060 227-241 NN denotes susceptibility
T1061 242-244 IN denotes to
T1062 245-252 NN denotes obesity
T1063 252-254 , denotes ,
T1064 254-269 NN denotes atherosclerosis
T1065 269-271 , denotes ,
T1066 271-274 CC denotes and
T1067 275-281 NN denotes vessel
T1068 282-292 NN denotes remodeling
T1069 292-293 . denotes .
T1070 293-418 sentence denotes However, it is unclear how these diverse genetic backgrounds influence pathways known to regulate thrombosis and hemostasis.
T1071 294-301 RB denotes However
T1073 301-303 , denotes ,
T1074 303-305 PRP denotes it
T1072 306-308 VBZ denotes is
T1075 309-316 JJ denotes unclear
T1076 317-320 WRB denotes how
T1078 321-326 DT denotes these
T1080 327-334 JJ denotes diverse
T1081 335-342 JJ denotes genetic
T1079 343-354 NNS denotes backgrounds
T1077 355-364 VBP denotes influence
T1082 365-373 NNS denotes pathways
T1083 374-379 VBN denotes known
T1084 380-382 TO denotes to
T1085 383-391 VB denotes regulate
T1086 392-402 NN denotes thrombosis
T1087 403-406 CC denotes and
T1088 407-417 NN denotes hemostasis
T1089 417-418 . denotes .
T1090 418-601 sentence denotes The objective of this study was to evaluate thrombosis and hemostasis in these two inbred strains and determine the phenotypic response of A/J chromosomes in the C57BL/6J background.
T1091 419-422 DT denotes The
T1092 423-432 NN denotes objective
T1094 433-435 IN denotes of
T1095 436-440 DT denotes this
T1096 441-446 NN denotes study
T1093 447-450 VBD denotes was
T1097 451-453 TO denotes to
T1098 454-462 VB denotes evaluate
T1099 463-473 NN denotes thrombosis
T1100 474-477 CC denotes and
T1101 478-488 NN denotes hemostasis
T1102 489-491 IN denotes in
T1103 492-497 DT denotes these
T1105 498-501 CD denotes two
T1106 502-508 JJ denotes inbred
T1104 509-516 NNS denotes strains
T1107 517-520 CC denotes and
T1108 521-530 VB denotes determine
T1109 531-534 DT denotes the
T1111 535-545 JJ denotes phenotypic
T1110 546-554 NN denotes response
T1112 555-557 IN denotes of
T1113 558-559 NN denotes A
T1115 559-560 HYPH denotes /
T1114 560-561 NN denotes J
T1116 562-573 NNS denotes chromosomes
T1117 574-576 IN denotes in
T1118 577-580 DT denotes the
T1120 581-586 NN denotes C57BL
T1122 586-587 HYPH denotes /
T1121 587-589 NN denotes 6J
T1119 590-600 NN denotes background
T1123 600-601 . denotes .
T1124 601-610 sentence denotes Methods
T1125 603-610 NNS denotes Methods
T1126 610-693 sentence denotes A/J and C57Bl/6J mice were evaluated for differences in thrombosis and hemostasis.
T1127 611-612 NN denotes A
T1129 612-613 HYPH denotes /
T1128 613-614 NN denotes J
T1131 615-618 CC denotes and
T1132 619-624 NN denotes C57Bl
T1134 624-625 HYPH denotes /
T1133 625-627 NN denotes 6J
T1130 628-632 NNS denotes mice
T1136 633-637 VBD denotes were
T1135 638-647 VBN denotes evaluated
T1137 648-651 IN denotes for
T1138 652-663 NNS denotes differences
T1139 664-666 IN denotes in
T1140 667-677 NN denotes thrombosis
T1141 678-681 CC denotes and
T1142 682-692 NN denotes hemostasis
T1143 692-693 . denotes .
T1144 693-846 sentence denotes A thrombus was induced in the carotid artery by application of the exposed carotid to ferric chloride and blood flow measured until the vessel occluded.
T1145 694-695 DT denotes A
T1146 696-704 NN denotes thrombus
T1148 705-708 VBD denotes was
T1147 709-716 VBN denotes induced
T1149 717-719 IN denotes in
T1150 720-723 DT denotes the
T1152 724-731 JJ denotes carotid
T1151 732-738 NN denotes artery
T1153 739-741 IN denotes by
T1154 742-753 NN denotes application
T1155 754-756 IN denotes of
T1156 757-760 DT denotes the
T1158 761-768 VBN denotes exposed
T1157 769-776 NN denotes carotid
T1159 777-779 IN denotes to
T1160 780-786 JJ denotes ferric
T1161 787-795 NN denotes chloride
T1162 796-799 CC denotes and
T1163 800-805 NN denotes blood
T1164 806-810 NN denotes flow
T1165 811-819 VBN denotes measured
T1166 820-825 IN denotes until
T1168 826-829 DT denotes the
T1169 830-836 NN denotes vessel
T1167 837-845 VBD denotes occluded
T1170 845-846 . denotes .
T1171 846-997 sentence denotes Bleeding and rebleeding times, as surrogate markers for thrombosis and hemostasis, were determined after clipping the tail and placing in warm saline.
T1172 847-855 NN denotes Bleeding
T1174 856-859 CC denotes and
T1175 860-870 NN denotes rebleeding
T1173 871-876 NNS denotes times
T1177 876-878 , denotes ,
T1178 878-880 IN denotes as
T1179 881-890 JJ denotes surrogate
T1180 891-898 NNS denotes markers
T1181 899-902 IN denotes for
T1182 903-913 NN denotes thrombosis
T1183 914-917 CC denotes and
T1184 918-928 NN denotes hemostasis
T1185 928-930 , denotes ,
T1186 930-934 VBD denotes were
T1176 935-945 VBN denotes determined
T1187 946-951 IN denotes after
T1188 952-960 VBG denotes clipping
T1189 961-964 DT denotes the
T1190 965-969 NN denotes tail
T1191 970-973 CC denotes and
T1192 974-981 VBG denotes placing
T1193 982-984 IN denotes in
T1194 985-989 JJ denotes warm
T1195 990-996 NN denotes saline
T1196 996-997 . denotes .
T1197 997-1138 sentence denotes Twenty-one chromosome substitution strains, A/J chromosomes in a C57BL/6J background, were screened for response to the tail bleeding assay.
T1198 998-1004 CD denotes Twenty
T1200 1004-1005 HYPH denotes -
T1199 1005-1008 CD denotes one
T1202 1009-1019 NN denotes chromosome
T1203 1020-1032 NN denotes substitution
T1201 1033-1040 NNS denotes strains
T1205 1040-1042 , denotes ,
T1206 1042-1043 NN denotes A
T1208 1043-1044 HYPH denotes /
T1207 1044-1045 NN denotes J
T1209 1046-1057 NNS denotes chromosomes
T1210 1058-1060 IN denotes in
T1211 1061-1062 DT denotes a
T1213 1063-1068 NN denotes C57BL
T1215 1068-1069 HYPH denotes /
T1214 1069-1071 NN denotes 6J
T1212 1072-1082 NN denotes background
T1216 1082-1084 , denotes ,
T1217 1084-1088 VBD denotes were
T1204 1089-1097 VBN denotes screened
T1218 1098-1101 IN denotes for
T1219 1102-1110 NN denotes response
T1220 1111-1113 IN denotes to
T1221 1114-1117 DT denotes the
T1223 1118-1122 NN denotes tail
T1224 1123-1131 NN denotes bleeding
T1222 1132-1137 NN denotes assay
T1225 1137-1138 . denotes .
T1226 1138-1147 sentence denotes Results
T1227 1140-1147 NNS denotes Results
T1228 1147-1237 sentence denotes Thrombus occlusion time was markedly decreased in the A/J mice compared to C57BL/6J mice.
T1229 1148-1156 NN denotes Thrombus
T1230 1157-1166 NN denotes occlusion
T1231 1167-1171 NN denotes time
T1233 1172-1175 VBD denotes was
T1234 1176-1184 RB denotes markedly
T1232 1185-1194 VBN denotes decreased
T1235 1195-1197 IN denotes in
T1236 1198-1201 DT denotes the
T1238 1202-1203 NN denotes A
T1240 1203-1204 HYPH denotes /
T1239 1204-1205 NN denotes J
T1237 1206-1210 NNS denotes mice
T1241 1211-1219 VBN denotes compared
T1242 1220-1222 IN denotes to
T1243 1223-1228 NN denotes C57BL
T1245 1228-1229 HYPH denotes /
T1244 1229-1231 NN denotes 6J
T1246 1232-1236 NNS denotes mice
T1247 1236-1237 . denotes .
T1248 1237-1374 sentence denotes Tail bleeding time was similar in the two strains, but rebleeding time was markedly increased in the A/J mice compared to C57BL/6J mice.
T1249 1238-1242 NN denotes Tail
T1250 1243-1251 NN denotes bleeding
T1251 1252-1256 NN denotes time
T1252 1257-1260 VBD denotes was
T1253 1261-1268 JJ denotes similar
T1254 1269-1271 IN denotes in
T1255 1272-1275 DT denotes the
T1257 1276-1279 CD denotes two
T1256 1280-1287 NNS denotes strains
T1258 1287-1289 , denotes ,
T1259 1289-1292 CC denotes but
T1260 1293-1303 NN denotes rebleeding
T1261 1304-1308 NN denotes time
T1263 1309-1312 VBD denotes was
T1264 1313-1321 RB denotes markedly
T1262 1322-1331 VBN denotes increased
T1265 1332-1334 IN denotes in
T1266 1335-1338 DT denotes the
T1268 1339-1340 NN denotes A
T1270 1340-1341 HYPH denotes /
T1269 1341-1342 NN denotes J
T1267 1343-1347 NNS denotes mice
T1271 1348-1356 VBN denotes compared
T1272 1357-1359 IN denotes to
T1273 1360-1365 NN denotes C57BL
T1275 1365-1366 HYPH denotes /
T1274 1366-1368 NN denotes 6J
T1276 1369-1373 NNS denotes mice
T1277 1373-1374 . denotes .
T1278 1374-1490 sentence denotes Coagulation times and tail morphology were similar, but tail collagen content was higher in A/J than C57BL/6J mice.
T1279 1375-1386 NN denotes Coagulation
T1280 1387-1392 NNS denotes times
T1282 1393-1396 CC denotes and
T1283 1397-1401 NN denotes tail
T1284 1402-1412 NN denotes morphology
T1281 1413-1417 VBD denotes were
T1285 1418-1425 JJ denotes similar
T1286 1425-1427 , denotes ,
T1287 1427-1430 CC denotes but
T1288 1431-1435 NN denotes tail
T1289 1436-1444 NN denotes collagen
T1290 1445-1452 NN denotes content
T1291 1453-1456 VBD denotes was
T1292 1457-1463 JJR denotes higher
T1293 1464-1466 IN denotes in
T1294 1467-1468 NN denotes A
T1296 1468-1469 HYPH denotes /
T1295 1469-1470 NN denotes J
T1297 1471-1475 IN denotes than
T1298 1476-1481 NN denotes C57BL
T1300 1481-1482 HYPH denotes /
T1299 1482-1484 NN denotes 6J
T1301 1485-1489 NNS denotes mice
T1302 1489-1490 . denotes .
T1303 1490-1652 sentence denotes Three chromosome substitution strains, B6-Chr5A/J, B6-Chr11A/J, and B6-Chr17A/J, were identified with increased rebleeding time, a phenotype similar to A/J mice.
T1304 1491-1496 CD denotes Three
T1306 1497-1507 NN denotes chromosome
T1307 1508-1520 NN denotes substitution
T1305 1521-1528 NNS denotes strains
T1309 1528-1530 , denotes ,
T1310 1530-1532 NN denotes B6
T1312 1532-1533 HYPH denotes -
T1311 1533-1538 NN denotes Chr5A
T1314 1538-1539 HYPH denotes /
T1313 1539-1540 NN denotes J
T1315 1540-1542 , denotes ,
T1316 1542-1544 NN denotes B6
T1318 1544-1545 HYPH denotes -
T1317 1545-1551 NN denotes Chr11A
T1320 1551-1552 HYPH denotes /
T1319 1552-1553 NN denotes J
T1321 1553-1555 , denotes ,
T1322 1555-1558 CC denotes and
T1323 1559-1561 NN denotes B6
T1325 1561-1562 HYPH denotes -
T1324 1562-1568 NN denotes Chr17A
T1327 1568-1569 HYPH denotes /
T1326 1569-1570 NN denotes J
T1328 1570-1572 , denotes ,
T1329 1572-1576 VBD denotes were
T1308 1577-1587 VBN denotes identified
T1330 1588-1592 IN denotes with
T1331 1593-1602 VBN denotes increased
T1333 1603-1613 NN denotes rebleeding
T1332 1614-1618 NN denotes time
T1334 1618-1620 , denotes ,
T1335 1620-1621 DT denotes a
T1336 1622-1631 NN denotes phenotype
T1337 1632-1639 JJ denotes similar
T1338 1640-1642 IN denotes to
T1339 1643-1644 NN denotes A
T1341 1644-1645 HYPH denotes /
T1340 1645-1646 NN denotes J
T1342 1647-1651 NNS denotes mice
T1343 1651-1652 . denotes .
T1344 1652-1902 sentence denotes Mice heterosomic for chromosomes 5 or 17 had rebleeding times similar to C57BL/6J mice, but when these two chromosome substitution strains, B6-Chr5A/J and B6-Chr17A/J, were crossed, the A/J phenotype was restored in these doubly heterosomic progeny.
T1345 1653-1657 NNS denotes Mice
T1347 1658-1669 JJ denotes heterosomic
T1348 1670-1673 IN denotes for
T1349 1674-1685 NNS denotes chromosomes
T1350 1686-1687 CD denotes 5
T1351 1688-1690 CC denotes or
T1352 1691-1693 CD denotes 17
T1346 1694-1697 VBD denotes had
T1353 1698-1708 NN denotes rebleeding
T1354 1709-1714 NNS denotes times
T1355 1715-1722 JJ denotes similar
T1356 1723-1725 IN denotes to
T1357 1726-1731 NN denotes C57BL
T1359 1731-1732 HYPH denotes /
T1358 1732-1734 NN denotes 6J
T1360 1735-1739 NNS denotes mice
T1361 1739-1741 , denotes ,
T1362 1741-1744 CC denotes but
T1363 1745-1749 IN denotes when
T1365 1750-1755 DT denotes these
T1367 1756-1759 CD denotes two
T1368 1760-1770 NN denotes chromosome
T1369 1771-1783 NN denotes substitution
T1366 1784-1791 NNS denotes strains
T1370 1791-1793 , denotes ,
T1371 1793-1795 NN denotes B6
T1373 1795-1796 HYPH denotes -
T1372 1796-1801 NN denotes Chr5A
T1375 1801-1802 HYPH denotes /
T1374 1802-1803 NN denotes J
T1376 1804-1807 CC denotes and
T1377 1808-1810 NN denotes B6
T1379 1810-1811 HYPH denotes -
T1378 1811-1817 NN denotes Chr17A
T1381 1817-1818 HYPH denotes /
T1380 1818-1819 NN denotes J
T1382 1819-1821 , denotes ,
T1383 1821-1825 VBD denotes were
T1364 1826-1833 VBN denotes crossed
T1385 1833-1835 , denotes ,
T1386 1835-1838 DT denotes the
T1388 1839-1840 NN denotes A
T1390 1840-1841 HYPH denotes /
T1389 1841-1842 NN denotes J
T1387 1843-1852 NN denotes phenotype
T1391 1853-1856 VBD denotes was
T1384 1857-1865 VBN denotes restored
T1392 1866-1868 IN denotes in
T1393 1869-1874 DT denotes these
T1395 1875-1881 RB denotes doubly
T1396 1882-1893 JJ denotes heterosomic
T1394 1894-1901 NN denotes progeny
T1397 1901-1902 . denotes .
T1398 1902-1914 sentence denotes Conclusion
T1399 1904-1914 NN denotes Conclusion
T1400 1914-2043 sentence denotes These results indicate that susceptibility to arterial thrombosis and haemostasis is remarkably different in C57BL/and A/J mice.
T1401 1915-1920 DT denotes These
T1402 1921-1928 NNS denotes results
T1403 1929-1937 VBP denotes indicate
T1404 1938-1942 IN denotes that
T1406 1943-1957 NN denotes susceptibility
T1407 1958-1960 IN denotes to
T1408 1961-1969 JJ denotes arterial
T1409 1970-1980 NN denotes thrombosis
T1410 1981-1984 CC denotes and
T1411 1985-1996 NN denotes haemostasis
T1405 1997-1999 VBZ denotes is
T1412 2000-2010 RB denotes remarkably
T1413 2011-2020 JJ denotes different
T1414 2021-2023 IN denotes in
T1415 2024-2029 NN denotes C57BL
T1417 2029-2030 HYPH denotes /
T1418 2030-2033 CC denotes and
T1419 2034-2035 NN denotes A
T1420 2035-2036 HYPH denotes /
T1416 2036-2037 NN denotes J
T1421 2038-2042 NNS denotes mice
T1422 2042-2043 . denotes .
T1423 2043-2279 sentence denotes Three A/J chromosome substitution strains were identified that expressed a phenotype similar to A/J for rebleeding, the C57Bl/6J background could modify the A/J phenotype, and the combination of two A/J QTL could restore the phenotype.
T1424 2044-2049 CD denotes Three
T1426 2050-2051 NN denotes A
T1428 2051-2052 HYPH denotes /
T1427 2052-2053 NN denotes J
T1429 2054-2064 NN denotes chromosome
T1430 2065-2077 NN denotes substitution
T1425 2078-2085 NNS denotes strains
T1432 2086-2090 VBD denotes were
T1431 2091-2101 VBN denotes identified
T1433 2102-2106 WDT denotes that
T1434 2107-2116 VBD denotes expressed
T1435 2117-2118 DT denotes a
T1436 2119-2128 NN denotes phenotype
T1437 2129-2136 JJ denotes similar
T1438 2137-2139 IN denotes to
T1439 2140-2141 NN denotes A
T1441 2141-2142 HYPH denotes /
T1440 2142-2143 NN denotes J
T1442 2144-2147 IN denotes for
T1443 2148-2158 VBG denotes rebleeding
T1444 2158-2160 , denotes ,
T1445 2160-2163 DT denotes the
T1447 2164-2169 NN denotes C57Bl
T1449 2169-2170 HYPH denotes /
T1448 2170-2172 NN denotes 6J
T1446 2173-2183 NN denotes background
T1451 2184-2189 MD denotes could
T1450 2190-2196 VB denotes modify
T1452 2197-2200 DT denotes the
T1454 2201-2202 NN denotes A
T1456 2202-2203 HYPH denotes /
T1455 2203-2204 NN denotes J
T1453 2205-2214 NN denotes phenotype
T1457 2214-2216 , denotes ,
T1458 2216-2219 CC denotes and
T1459 2220-2223 DT denotes the
T1460 2224-2235 NN denotes combination
T1462 2236-2238 IN denotes of
T1463 2239-2242 CD denotes two
T1465 2243-2244 NN denotes A
T1467 2244-2245 HYPH denotes /
T1466 2245-2246 NN denotes J
T1464 2247-2250 NN denotes QTL
T1468 2251-2256 MD denotes could
T1461 2257-2264 VB denotes restore
T1469 2265-2268 DT denotes the
T1470 2269-2278 NN denotes phenotype
T1471 2278-2279 . denotes .
T1472 2279-2491 sentence denotes The diverse genetic backgrounds and differences in response to vascular injury induced thrombosis and the tail bleeding assay, suggest the potential for identifying novel genetic determinants of thrombotic risk.
T1473 2280-2283 DT denotes The
T1475 2284-2291 JJ denotes diverse
T1476 2292-2299 JJ denotes genetic
T1474 2300-2311 NNS denotes backgrounds
T1478 2312-2315 CC denotes and
T1479 2316-2327 NNS denotes differences
T1480 2328-2330 IN denotes in
T1481 2331-2339 NN denotes response
T1482 2340-2342 IN denotes to
T1483 2343-2351 JJ denotes vascular
T1484 2352-2358 NN denotes injury
T1485 2359-2366 VBN denotes induced
T1486 2367-2377 NN denotes thrombosis
T1487 2378-2381 CC denotes and
T1488 2382-2385 DT denotes the
T1490 2386-2390 NN denotes tail
T1491 2391-2399 NN denotes bleeding
T1489 2400-2405 NN denotes assay
T1492 2405-2407 , denotes ,
T1477 2407-2414 VBP denotes suggest
T1493 2415-2418 DT denotes the
T1494 2419-2428 NN denotes potential
T1495 2429-2432 IN denotes for
T1496 2433-2444 VBG denotes identifying
T1497 2445-2450 JJ denotes novel
T1499 2451-2458 JJ denotes genetic
T1498 2459-2471 NNS denotes determinants
T1500 2472-2474 IN denotes of
T1501 2475-2485 JJ denotes thrombotic
T1502 2486-2490 NN denotes risk
T1503 2490-2491 . denotes .
R10 T1024 T1023 amod fatal,consequence
R100 T1120 T1121 compound C57BL,6J
R101 T1121 T1119 compound 6J,background
R102 T1122 T1121 punct /,6J
R103 T1123 T1093 punct .,was
R104 T1127 T1128 nmod A,J
R105 T1128 T1130 nmod J,mice
R106 T1129 T1128 punct /,J
R107 T1130 T1135 nsubjpass mice,evaluated
R108 T1131 T1128 cc and,J
R109 T1132 T1133 compound C57Bl,6J
R11 T1025 T1024 cc and,fatal
R110 T1133 T1128 conj 6J,J
R111 T1134 T1133 punct /,6J
R112 T1136 T1135 auxpass were,evaluated
R113 T1137 T1135 prep for,evaluated
R114 T1138 T1137 pobj differences,for
R115 T1139 T1138 prep in,differences
R116 T1140 T1139 pobj thrombosis,in
R117 T1141 T1140 cc and,thrombosis
R118 T1142 T1140 conj hemostasis,thrombosis
R119 T1143 T1135 punct .,evaluated
R12 T1026 T1024 conj disabling,fatal
R120 T1145 T1146 det A,thrombus
R121 T1146 T1147 nsubjpass thrombus,induced
R122 T1148 T1147 auxpass was,induced
R123 T1149 T1147 prep in,induced
R124 T1150 T1151 det the,artery
R125 T1151 T1149 pobj artery,in
R126 T1152 T1151 amod carotid,artery
R127 T1153 T1147 prep by,induced
R128 T1154 T1153 pobj application,by
R129 T1155 T1154 prep of,application
R13 T1027 T1023 prep of,consequence
R130 T1156 T1157 det the,carotid
R131 T1157 T1155 pobj carotid,of
R132 T1158 T1157 amod exposed,carotid
R133 T1159 T1154 prep to,application
R134 T1160 T1161 amod ferric,chloride
R135 T1161 T1159 pobj chloride,to
R136 T1162 T1147 cc and,induced
R137 T1163 T1164 compound blood,flow
R138 T1164 T1165 nsubj flow,measured
R139 T1165 T1147 conj measured,induced
R14 T1028 T1029 amod cardiovascular,diseases
R140 T1166 T1167 mark until,occluded
R141 T1167 T1165 advcl occluded,measured
R142 T1168 T1169 det the,vessel
R143 T1169 T1167 nsubj vessel,occluded
R144 T1170 T1165 punct .,measured
R145 T1172 T1173 nmod Bleeding,times
R146 T1173 T1176 nsubjpass times,determined
R147 T1174 T1172 cc and,Bleeding
R148 T1175 T1172 conj rebleeding,Bleeding
R149 T1177 T1173 punct ", ",times
R15 T1029 T1027 pobj diseases,of
R150 T1178 T1173 prep as,times
R151 T1179 T1180 amod surrogate,markers
R152 T1180 T1178 pobj markers,as
R153 T1181 T1180 prep for,markers
R154 T1182 T1181 pobj thrombosis,for
R155 T1183 T1182 cc and,thrombosis
R156 T1184 T1182 conj hemostasis,thrombosis
R157 T1185 T1176 punct ", ",determined
R158 T1186 T1176 auxpass were,determined
R159 T1187 T1176 prep after,determined
R16 T1030 T1029 punct ", ",diseases
R160 T1188 T1187 pcomp clipping,after
R161 T1189 T1190 det the,tail
R162 T1190 T1188 dobj tail,clipping
R163 T1191 T1188 cc and,clipping
R164 T1192 T1188 conj placing,clipping
R165 T1193 T1192 prep in,placing
R166 T1194 T1195 amod warm,saline
R167 T1195 T1193 pobj saline,in
R168 T1196 T1176 punct .,determined
R169 T1198 T1199 compound Twenty,one
R17 T1031 T1032 det the,cause
R170 T1199 T1201 nummod one,strains
R171 T1200 T1199 punct -,one
R172 T1201 T1204 nsubjpass strains,screened
R173 T1202 T1201 compound chromosome,strains
R174 T1203 T1201 compound substitution,strains
R175 T1205 T1201 punct ", ",strains
R176 T1206 T1207 compound A,J
R177 T1207 T1209 compound J,chromosomes
R178 T1208 T1207 punct /,J
R179 T1209 T1201 appos chromosomes,strains
R18 T1032 T1029 appos cause,diseases
R180 T1210 T1209 prep in,chromosomes
R181 T1211 T1212 det a,background
R182 T1212 T1210 pobj background,in
R183 T1213 T1214 compound C57BL,6J
R184 T1214 T1212 compound 6J,background
R185 T1215 T1214 punct /,6J
R186 T1216 T1204 punct ", ",screened
R187 T1217 T1204 auxpass were,screened
R188 T1218 T1204 prep for,screened
R189 T1219 T1218 pobj response,for
R19 T1033 T1032 amod leading,cause
R190 T1220 T1219 prep to,response
R191 T1221 T1222 det the,assay
R192 T1222 T1220 pobj assay,to
R193 T1223 T1224 compound tail,bleeding
R194 T1224 T1222 compound bleeding,assay
R195 T1225 T1204 punct .,screened
R196 T1229 T1230 compound Thrombus,occlusion
R197 T1230 T1231 compound occlusion,time
R198 T1231 T1232 nsubjpass time,decreased
R199 T1233 T1232 auxpass was,decreased
R20 T1034 T1032 prep of,cause
R200 T1234 T1232 advmod markedly,decreased
R201 T1235 T1232 prep in,decreased
R202 T1236 T1237 det the,mice
R203 T1237 T1235 pobj mice,in
R204 T1238 T1239 compound A,J
R205 T1239 T1237 compound J,mice
R206 T1240 T1239 punct /,J
R207 T1241 T1232 prep compared,decreased
R208 T1242 T1241 prep to,compared
R209 T1243 T1244 compound C57BL,6J
R21 T1035 T1034 pobj mortality,of
R210 T1244 T1246 compound 6J,mice
R211 T1245 T1244 punct /,6J
R212 T1246 T1242 pobj mice,to
R213 T1247 T1232 punct .,decreased
R214 T1249 T1250 compound Tail,bleeding
R215 T1250 T1251 compound bleeding,time
R216 T1251 T1252 nsubj time,was
R217 T1253 T1252 acomp similar,was
R218 T1254 T1252 prep in,was
R219 T1255 T1256 det the,strains
R22 T1036 T1035 cc and,mortality
R220 T1256 T1254 pobj strains,in
R221 T1257 T1256 nummod two,strains
R222 T1258 T1252 punct ", ",was
R223 T1259 T1252 cc but,was
R224 T1260 T1261 compound rebleeding,time
R225 T1261 T1262 nsubjpass time,increased
R226 T1262 T1252 conj increased,was
R227 T1263 T1262 auxpass was,increased
R228 T1264 T1262 advmod markedly,increased
R229 T1265 T1262 prep in,increased
R23 T1037 T1035 conj morbidity,mortality
R230 T1266 T1267 det the,mice
R231 T1267 T1265 pobj mice,in
R232 T1268 T1269 compound A,J
R233 T1269 T1267 compound J,mice
R234 T1270 T1269 punct /,J
R235 T1271 T1262 prep compared,increased
R236 T1272 T1271 prep to,compared
R237 T1273 T1274 compound C57BL,6J
R238 T1274 T1276 compound 6J,mice
R239 T1275 T1274 punct /,6J
R24 T1038 T1032 prep in,cause
R240 T1276 T1272 pobj mice,to
R241 T1277 T1262 punct .,increased
R242 T1279 T1280 compound Coagulation,times
R243 T1280 T1281 nsubj times,were
R244 T1282 T1280 cc and,times
R245 T1283 T1284 compound tail,morphology
R246 T1284 T1280 conj morphology,times
R247 T1285 T1281 acomp similar,were
R248 T1286 T1281 punct ", ",were
R249 T1287 T1281 cc but,were
R25 T1039 T1040 amod Western,countries
R250 T1288 T1289 compound tail,collagen
R251 T1289 T1290 compound collagen,content
R252 T1290 T1291 nsubj content,was
R253 T1291 T1281 conj was,were
R254 T1292 T1291 acomp higher,was
R255 T1293 T1291 prep in,was
R256 T1294 T1295 compound A,J
R257 T1295 T1293 pobj J,in
R258 T1296 T1295 punct /,J
R259 T1297 T1291 prep than,was
R26 T1040 T1038 pobj countries,in
R260 T1298 T1299 compound C57BL,6J
R261 T1299 T1297 pobj 6J,than
R262 T1300 T1299 punct /,6J
R263 T1301 T1291 dobj mice,was
R264 T1302 T1291 punct .,was
R265 T1304 T1305 nummod Three,strains
R266 T1305 T1308 nsubjpass strains,identified
R267 T1306 T1305 compound chromosome,strains
R268 T1307 T1305 compound substitution,strains
R269 T1309 T1305 punct ", ",strains
R27 T1041 T1021 punct .,is
R270 T1310 T1311 compound B6,Chr5A
R271 T1311 T1313 compound Chr5A,J
R272 T1312 T1311 punct -,Chr5A
R273 T1313 T1305 appos J,strains
R274 T1314 T1313 punct /,J
R275 T1315 T1313 punct ", ",J
R276 T1316 T1317 compound B6,Chr11A
R277 T1317 T1319 compound Chr11A,J
R278 T1318 T1317 punct -,Chr11A
R279 T1319 T1313 conj J,J
R28 T1043 T1044 nummod Two,strains
R280 T1320 T1319 punct /,J
R281 T1321 T1319 punct ", ",J
R282 T1322 T1319 cc and,J
R283 T1323 T1324 compound B6,Chr17A
R284 T1324 T1326 compound Chr17A,J
R285 T1325 T1324 punct -,Chr17A
R286 T1326 T1319 conj J,J
R287 T1327 T1326 punct /,J
R288 T1328 T1308 punct ", ",identified
R289 T1329 T1308 auxpass were,identified
R29 T1044 T1047 nsubj strains,have
R290 T1330 T1308 prep with,identified
R291 T1331 T1332 amod increased,time
R292 T1332 T1330 pobj time,with
R293 T1333 T1332 compound rebleeding,time
R294 T1334 T1332 punct ", ",time
R295 T1335 T1336 det a,phenotype
R296 T1336 T1332 appos phenotype,time
R297 T1337 T1336 amod similar,phenotype
R298 T1338 T1337 prep to,similar
R299 T1339 T1340 compound A,J
R30 T1045 T1044 amod inbred,strains
R300 T1340 T1342 compound J,mice
R301 T1341 T1340 punct /,J
R302 T1342 T1338 pobj mice,to
R303 T1343 T1308 punct .,identified
R304 T1345 T1346 nsubj Mice,had
R305 T1347 T1345 amod heterosomic,Mice
R306 T1348 T1347 prep for,heterosomic
R307 T1349 T1350 nmod chromosomes,5
R308 T1350 T1348 pobj 5,for
R309 T1351 T1350 cc or,5
R31 T1046 T1044 compound mouse,strains
R310 T1352 T1350 conj 17,5
R311 T1353 T1354 compound rebleeding,times
R312 T1354 T1346 dobj times,had
R313 T1355 T1354 amod similar,times
R314 T1356 T1355 prep to,similar
R315 T1357 T1358 compound C57BL,6J
R316 T1358 T1360 compound 6J,mice
R317 T1359 T1358 punct /,6J
R318 T1360 T1356 pobj mice,to
R319 T1361 T1346 punct ", ",had
R32 T1048 T1044 punct ", ",strains
R320 T1362 T1346 cc but,had
R321 T1363 T1364 prep when,crossed
R322 T1364 T1384 advcl crossed,restored
R323 T1365 T1366 det these,strains
R324 T1366 T1364 nsubjpass strains,crossed
R325 T1367 T1366 nummod two,strains
R326 T1368 T1366 compound chromosome,strains
R327 T1369 T1366 compound substitution,strains
R328 T1370 T1366 punct ", ",strains
R329 T1371 T1372 compound B6,Chr5A
R33 T1049 T1050 compound C57BL,6J
R330 T1372 T1374 compound Chr5A,J
R331 T1373 T1372 punct -,Chr5A
R332 T1374 T1366 appos J,strains
R333 T1375 T1374 punct /,J
R334 T1376 T1374 cc and,J
R335 T1377 T1378 compound B6,Chr17A
R336 T1378 T1380 compound Chr17A,J
R337 T1379 T1378 punct -,Chr17A
R338 T1380 T1374 conj J,J
R339 T1381 T1380 punct /,J
R34 T1050 T1044 appos 6J,strains
R340 T1382 T1364 punct ", ",crossed
R341 T1383 T1364 auxpass were,crossed
R342 T1384 T1346 conj restored,had
R343 T1385 T1384 punct ", ",restored
R344 T1386 T1387 det the,phenotype
R345 T1387 T1384 nsubjpass phenotype,restored
R346 T1388 T1389 compound A,J
R347 T1389 T1387 compound J,phenotype
R348 T1390 T1389 punct /,J
R349 T1391 T1384 auxpass was,restored
R35 T1051 T1050 punct /,6J
R350 T1392 T1384 prep in,restored
R351 T1393 T1394 det these,progeny
R352 T1394 T1392 pobj progeny,in
R353 T1395 T1396 advmod doubly,heterosomic
R354 T1396 T1394 amod heterosomic,progeny
R355 T1397 T1384 punct .,restored
R356 T1401 T1402 det These,results
R357 T1402 T1403 nsubj results,indicate
R358 T1404 T1405 mark that,is
R359 T1405 T1403 ccomp is,indicate
R36 T1052 T1050 cc and,6J
R360 T1406 T1405 nsubj susceptibility,is
R361 T1407 T1406 prep to,susceptibility
R362 T1408 T1409 amod arterial,thrombosis
R363 T1409 T1407 pobj thrombosis,to
R364 T1410 T1409 cc and,thrombosis
R365 T1411 T1409 conj haemostasis,thrombosis
R366 T1412 T1413 advmod remarkably,different
R367 T1413 T1405 acomp different,is
R368 T1414 T1405 prep in,is
R369 T1415 T1416 nmod C57BL,J
R37 T1053 T1054 compound A,J
R370 T1416 T1421 compound J,mice
R371 T1417 T1415 punct /,C57BL
R372 T1418 T1415 cc and,C57BL
R373 T1419 T1415 conj A,C57BL
R374 T1420 T1419 punct /,A
R375 T1421 T1414 pobj mice,in
R376 T1422 T1403 punct .,indicate
R377 T1424 T1425 nummod Three,strains
R378 T1425 T1431 nsubjpass strains,identified
R379 T1426 T1427 compound A,J
R38 T1054 T1050 conj J,6J
R380 T1427 T1425 compound J,strains
R381 T1428 T1427 punct /,J
R382 T1429 T1425 compound chromosome,strains
R383 T1430 T1425 compound substitution,strains
R384 T1432 T1431 auxpass were,identified
R385 T1433 T1434 dep that,expressed
R386 T1434 T1431 ccomp expressed,identified
R387 T1435 T1436 det a,phenotype
R388 T1436 T1434 dobj phenotype,expressed
R389 T1437 T1436 amod similar,phenotype
R39 T1055 T1054 punct /,J
R390 T1438 T1437 prep to,similar
R391 T1439 T1440 compound A,J
R392 T1440 T1438 pobj J,to
R393 T1441 T1440 punct /,J
R394 T1442 T1431 prep for,identified
R395 T1443 T1442 pobj rebleeding,for
R396 T1444 T1431 punct ", ",identified
R397 T1445 T1446 det the,background
R398 T1446 T1450 nsubj background,modify
R399 T1447 T1448 compound C57Bl,6J
R40 T1056 T1047 punct ", ",have
R400 T1448 T1446 compound 6J,background
R401 T1449 T1448 punct /,6J
R402 T1450 T1431 conj modify,identified
R403 T1451 T1450 aux could,modify
R404 T1452 T1453 det the,phenotype
R405 T1453 T1450 dobj phenotype,modify
R406 T1454 T1455 compound A,J
R407 T1455 T1453 compound J,phenotype
R408 T1456 T1455 punct /,J
R409 T1457 T1450 punct ", ",modify
R41 T1057 T1058 amod marked,differences
R410 T1458 T1450 cc and,modify
R411 T1459 T1460 det the,combination
R412 T1460 T1461 nsubj combination,restore
R413 T1461 T1450 conj restore,modify
R414 T1462 T1460 prep of,combination
R415 T1463 T1464 nummod two,QTL
R416 T1464 T1462 pobj QTL,of
R417 T1465 T1466 compound A,J
R418 T1466 T1464 compound J,QTL
R419 T1467 T1466 punct /,J
R42 T1058 T1047 dobj differences,have
R420 T1468 T1461 aux could,restore
R421 T1469 T1470 det the,phenotype
R422 T1470 T1461 dobj phenotype,restore
R423 T1471 T1461 punct .,restore
R424 T1473 T1474 det The,backgrounds
R425 T1474 T1477 nsubj backgrounds,suggest
R426 T1475 T1474 amod diverse,backgrounds
R427 T1476 T1474 amod genetic,backgrounds
R428 T1478 T1474 cc and,backgrounds
R429 T1479 T1474 conj differences,backgrounds
R43 T1059 T1058 prep in,differences
R430 T1480 T1479 prep in,differences
R431 T1481 T1480 pobj response,in
R432 T1482 T1481 prep to,response
R433 T1483 T1484 amod vascular,injury
R434 T1484 T1485 npadvmod injury,induced
R435 T1485 T1486 amod induced,thrombosis
R436 T1486 T1482 pobj thrombosis,to
R437 T1487 T1486 cc and,thrombosis
R438 T1488 T1489 det the,assay
R439 T1489 T1486 conj assay,thrombosis
R44 T1060 T1059 pobj susceptibility,in
R440 T1490 T1491 compound tail,bleeding
R441 T1491 T1489 compound bleeding,assay
R442 T1492 T1477 punct ", ",suggest
R443 T1493 T1494 det the,potential
R444 T1494 T1477 dobj potential,suggest
R445 T1495 T1494 prep for,potential
R446 T1496 T1495 pcomp identifying,for
R447 T1497 T1498 amod novel,determinants
R448 T1498 T1496 dobj determinants,identifying
R449 T1499 T1498 amod genetic,determinants
R45 T1061 T1060 prep to,susceptibility
R450 T1500 T1498 prep of,determinants
R451 T1501 T1502 amod thrombotic,risk
R452 T1502 T1500 pobj risk,of
R453 T1503 T1477 punct .,suggest
R46 T1062 T1061 pobj obesity,to
R47 T1063 T1062 punct ", ",obesity
R48 T1064 T1062 conj atherosclerosis,obesity
R49 T1065 T1064 punct ", ",atherosclerosis
R50 T1066 T1064 cc and,atherosclerosis
R51 T1067 T1068 compound vessel,remodeling
R52 T1068 T1064 conj remodeling,atherosclerosis
R53 T1069 T1047 punct .,have
R54 T1071 T1072 advmod However,is
R55 T1073 T1072 punct ", ",is
R56 T1074 T1072 nsubj it,is
R57 T1075 T1072 acomp unclear,is
R58 T1076 T1077 advmod how,influence
R59 T1077 T1072 ccomp influence,is
R60 T1078 T1079 det these,backgrounds
R61 T1079 T1077 nsubj backgrounds,influence
R62 T1080 T1079 amod diverse,backgrounds
R63 T1081 T1079 amod genetic,backgrounds
R64 T1082 T1077 dobj pathways,influence
R65 T1083 T1082 acl known,pathways
R66 T1084 T1085 aux to,regulate
R67 T1085 T1083 xcomp regulate,known
R68 T1086 T1085 dobj thrombosis,regulate
R69 T1087 T1086 cc and,thrombosis
R7 T1020 T1021 nsubj Thrombosis,is
R70 T1088 T1086 conj hemostasis,thrombosis
R71 T1089 T1072 punct .,is
R72 T1091 T1092 det The,objective
R73 T1092 T1093 nsubj objective,was
R74 T1094 T1092 prep of,objective
R75 T1095 T1096 det this,study
R76 T1096 T1094 pobj study,of
R77 T1097 T1098 aux to,evaluate
R78 T1098 T1093 xcomp evaluate,was
R79 T1099 T1098 dobj thrombosis,evaluate
R8 T1022 T1023 det the,consequence
R80 T1100 T1099 cc and,thrombosis
R81 T1101 T1099 conj hemostasis,thrombosis
R82 T1102 T1098 prep in,evaluate
R83 T1103 T1104 det these,strains
R84 T1104 T1102 pobj strains,in
R85 T1105 T1104 nummod two,strains
R86 T1106 T1104 amod inbred,strains
R87 T1107 T1098 cc and,evaluate
R88 T1108 T1098 conj determine,evaluate
R89 T1109 T1110 det the,response
R9 T1023 T1021 attr consequence,is
R90 T1110 T1108 dobj response,determine
R91 T1111 T1110 amod phenotypic,response
R92 T1112 T1110 prep of,response
R93 T1113 T1114 compound A,J
R94 T1114 T1116 compound J,chromosomes
R95 T1115 T1114 punct /,J
R96 T1116 T1112 pobj chromosomes,of
R97 T1117 T1108 prep in,determine
R98 T1118 T1119 det the,background
R99 T1119 T1117 pobj background,in