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PMC:1617083 / 30782-32090 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T19091 0-3 DT denotes The
T19093 4-8 NN denotes tail
T19095 8-9 HYPH denotes -
T19094 9-17 NN denotes bleeding
T19092 18-23 NN denotes assay
T19097 24-27 VBZ denotes has
T19098 28-32 VBN denotes been
T19096 33-37 VBN denotes used
T19099 38-49 RB denotes extensively
T19100 50-52 IN denotes in
T19101 53-57 NNS denotes mice
T19102 58-60 TO denotes to
T19103 61-67 VB denotes assess
T19104 68-71 DT denotes the
T19105 72-78 NN denotes impact
T19106 79-81 IN denotes of
T19107 82-94 NNS denotes deficiencies
T19108 95-98 CC denotes and
T19109 99-103 RB denotes over
T19110 104-114 NN denotes expression
T19111 115-117 IN denotes of
T19112 118-126 NN denotes platelet
T19114 127-130 CC denotes and
T19115 131-142 NN denotes coagulation
T19113 143-151 NN denotes proteins
T19116 152-154 IN denotes in
T19117 155-159 NNS denotes mice
T19118 159-160 . denotes .
T19119 160-308 sentence denotes Sweeny et al [28] screened 25 strains of mice and found only the RIIS/J mice to have increased bleeding time due to reduced von Willebrand antigen.
T19120 161-167 NNP denotes Sweeny
T19122 168-170 FW denotes et
T19123 171-173 FW denotes al
T19124 174-175 -LRB- denotes [
T19125 175-177 CD denotes 28
T19126 177-178 -RRB- denotes ]
T19121 179-187 VBD denotes screened
T19127 188-190 CD denotes 25
T19128 191-198 NNS denotes strains
T19129 199-201 IN denotes of
T19130 202-206 NNS denotes mice
T19131 207-210 CC denotes and
T19132 211-216 VBN denotes found
T19133 217-221 RB denotes only
T19135 222-225 DT denotes the
T19136 226-230 NN denotes RIIS
T19138 230-231 HYPH denotes /
T19137 231-232 NN denotes J
T19134 233-237 NNS denotes mice
T19140 238-240 TO denotes to
T19139 241-245 VB denotes have
T19141 246-255 VBN denotes increased
T19143 256-264 NN denotes bleeding
T19142 265-269 NN denotes time
T19144 270-273 IN denotes due
T19145 274-276 IN denotes to
T19146 277-284 VBN denotes reduced
T19148 285-288 NNP denotes von
T19149 289-299 NNP denotes Willebrand
T19147 300-307 NN denotes antigen
T19150 307-308 . denotes .
T19151 308-530 sentence denotes Broze et al [29] evaluated mice with gene deletions of the coagulation pathway and found that while bleeding time was not increased, rebleeding persisted despite electrocautery of the tail in FVIII and FIX deficient mice.
T19152 309-314 NNP denotes Broze
T19154 315-317 FW denotes et
T19155 318-320 FW denotes al
T19156 321-322 -LRB- denotes [
T19157 322-324 CD denotes 29
T19158 324-325 -RRB- denotes ]
T19153 326-335 VBN denotes evaluated
T19159 336-340 NNS denotes mice
T19160 341-345 IN denotes with
T19161 346-350 NN denotes gene
T19162 351-360 NNS denotes deletions
T19163 361-363 IN denotes of
T19164 364-367 DT denotes the
T19166 368-379 NN denotes coagulation
T19165 380-387 NN denotes pathway
T19167 388-391 CC denotes and
T19168 392-397 VBD denotes found
T19169 398-402 IN denotes that
T19171 403-408 IN denotes while
T19173 409-417 NN denotes bleeding
T19174 418-422 NN denotes time
T19175 423-426 VBD denotes was
T19176 427-430 RB denotes not
T19172 431-440 VBN denotes increased
T19177 440-442 , denotes ,
T19178 442-452 NN denotes rebleeding
T19170 453-462 VBD denotes persisted
T19179 463-470 IN denotes despite
T19180 471-485 NN denotes electrocautery
T19181 486-488 IN denotes of
T19182 489-492 DT denotes the
T19183 493-497 NN denotes tail
T19184 498-500 IN denotes in
T19185 501-506 NN denotes FVIII
T19187 507-510 CC denotes and
T19188 511-514 NN denotes FIX
T19186 515-524 JJ denotes deficient
T19189 525-529 NNS denotes mice
T19190 529-530 . denotes .
T19191 530-678 sentence denotes This observation raised the possibility that rebleeding time may be a sensitive reporter of genetic influences on thrombus formation and stability.
T19192 531-535 DT denotes This
T19193 536-547 NN denotes observation
T19194 548-554 VBD denotes raised
T19195 555-558 DT denotes the
T19196 559-570 NN denotes possibility
T19197 571-575 IN denotes that
T19199 576-586 NN denotes rebleeding
T19200 587-591 NN denotes time
T19201 592-595 MD denotes may
T19198 596-598 VB denotes be
T19202 599-600 DT denotes a
T19204 601-610 JJ denotes sensitive
T19203 611-619 NN denotes reporter
T19205 620-622 IN denotes of
T19206 623-630 JJ denotes genetic
T19207 631-641 NNS denotes influences
T19208 642-644 IN denotes on
T19209 645-653 NN denotes thrombus
T19210 654-663 NN denotes formation
T19211 664-667 CC denotes and
T19212 668-677 NN denotes stability
T19213 677-678 . denotes .
T19214 678-858 sentence denotes Mice that are deficient in factors required for normal platelet function, platelet glycoprotein Ib [30], and protease-activated receptor-4, [31] have increased tail bleeding time.
T19215 679-683 NNS denotes Mice
T19217 684-688 WDT denotes that
T19218 689-692 VBP denotes are
T19219 693-702 JJ denotes deficient
T19220 703-705 IN denotes in
T19221 706-713 NNS denotes factors
T19222 714-722 VBN denotes required
T19223 723-726 IN denotes for
T19224 727-733 JJ denotes normal
T19226 734-742 NN denotes platelet
T19225 743-751 NN denotes function
T19227 751-753 , denotes ,
T19228 753-761 NN denotes platelet
T19230 762-774 NN denotes glycoprotein
T19229 775-777 NN denotes Ib
T19231 778-779 -LRB- denotes [
T19232 779-781 CD denotes 30
T19233 781-782 -RRB- denotes ]
T19234 782-784 , denotes ,
T19235 784-787 CC denotes and
T19236 788-796 NN denotes protease
T19238 796-797 HYPH denotes -
T19237 797-806 VBN denotes activated
T19239 807-815 NN denotes receptor
T19240 815-816 HYPH denotes -
T19241 816-817 CD denotes 4
T19242 817-819 , denotes ,
T19243 819-820 -LRB- denotes [
T19244 820-822 CD denotes 31
T19245 822-823 -RRB- denotes ]
T19246 824-828 VBP denotes have
T19216 829-838 VBN denotes increased
T19247 839-843 NN denotes tail
T19248 844-852 NN denotes bleeding
T19249 853-857 NN denotes time
T19250 857-858 . denotes .
T19251 858-1129 sentence denotes The leptin deficiency with reduced platelet aggregation clearly shows a marked increase in bleeding time and the increased bleeding time in Plg-/- and uPA-/- mice suggests that Plg and uPA may exert an influence on platelet response to promote normal thrombus formation.
T19252 859-862 DT denotes The
T19254 863-869 NN denotes leptin
T19253 870-880 NN denotes deficiency
T19256 881-885 IN denotes with
T19257 886-893 VBN denotes reduced
T19259 894-902 NN denotes platelet
T19258 903-914 NN denotes aggregation
T19260 915-922 RB denotes clearly
T19255 923-928 VBZ denotes shows
T19261 929-930 DT denotes a
T19263 931-937 JJ denotes marked
T19262 938-946 NN denotes increase
T19264 947-949 IN denotes in
T19265 950-958 NN denotes bleeding
T19266 959-963 NN denotes time
T19267 964-967 CC denotes and
T19268 968-971 DT denotes the
T19270 972-981 VBN denotes increased
T19271 982-990 NN denotes bleeding
T19269 991-995 NN denotes time
T19273 996-998 IN denotes in
T19274 999-1002 NN denotes Plg
T19276 1002-1003 SYM denotes -
T19277 1003-1004 HYPH denotes /
T19278 1004-1005 SYM denotes -
T19279 1006-1009 CC denotes and
T19280 1010-1013 NN denotes uPA
T19281 1013-1014 SYM denotes -
T19282 1014-1015 HYPH denotes /
T19283 1015-1016 SYM denotes -
T19275 1017-1021 NNS denotes mice
T19272 1022-1030 VBZ denotes suggests
T19284 1031-1035 IN denotes that
T19286 1036-1039 NN denotes Plg
T19287 1040-1043 CC denotes and
T19288 1044-1047 NN denotes uPA
T19289 1048-1051 MD denotes may
T19285 1052-1057 VB denotes exert
T19290 1058-1060 DT denotes an
T19291 1061-1070 NN denotes influence
T19292 1071-1073 IN denotes on
T19293 1074-1082 NN denotes platelet
T19294 1083-1091 NN denotes response
T19295 1092-1094 TO denotes to
T19296 1095-1102 VB denotes promote
T19297 1103-1109 JJ denotes normal
T19299 1110-1118 NN denotes thrombus
T19298 1119-1128 NN denotes formation
T19300 1128-1129 . denotes .
T19301 1129-1308 sentence denotes Overall, the marked increase in rebleeding times observed in certain mouse strains suggests genetic factors other than coagulation may play a role in the stability of a thrombus.
T19302 1130-1137 RB denotes Overall
T19304 1137-1139 , denotes ,
T19305 1139-1142 DT denotes the
T19307 1143-1149 JJ denotes marked
T19306 1150-1158 NN denotes increase
T19308 1159-1161 IN denotes in
T19309 1162-1172 NN denotes rebleeding
T19310 1173-1178 NNS denotes times
T19311 1179-1187 VBN denotes observed
T19312 1188-1190 IN denotes in
T19313 1191-1198 JJ denotes certain
T19315 1199-1204 NN denotes mouse
T19314 1205-1212 NNS denotes strains
T19303 1213-1221 VBZ denotes suggests
T19316 1222-1229 JJ denotes genetic
T19317 1230-1237 NNS denotes factors
T19319 1238-1243 JJ denotes other
T19320 1244-1248 IN denotes than
T19321 1249-1260 NN denotes coagulation
T19322 1261-1264 MD denotes may
T19318 1265-1269 VB denotes play
T19323 1270-1271 DT denotes a
T19324 1272-1276 NN denotes role
T19325 1277-1279 IN denotes in
T19326 1280-1283 DT denotes the
T19327 1284-1293 NN denotes stability
T19328 1294-1296 IN denotes of
T19329 1297-1298 DT denotes a
T19330 1299-1307 NN denotes thrombus
T19331 1307-1308 . denotes .
R5188 T19091 T19092 det The,assay
R5189 T19092 T19096 nsubjpass assay,used
R5191 T19093 T19094 compound tail,bleeding
R5192 T19094 T19092 compound bleeding,assay
R5193 T19095 T19094 punct -,bleeding
R5195 T19097 T19096 aux has,used
R5197 T19098 T19096 auxpass been,used
R5199 T19099 T19096 advmod extensively,used
R5200 T19100 T19096 prep in,used
R5201 T19101 T19100 pobj mice,in
R5202 T19102 T19103 aux to,assess
R5204 T19103 T19096 advcl assess,used
R5205 T19104 T19105 det the,impact
R5206 T19105 T19103 dobj impact,assess
R5208 T19106 T19105 prep of,impact
R5210 T19107 T19106 pobj deficiencies,of
R5211 T19108 T19107 cc and,deficiencies
R5212 T19109 T19110 advmod over,expression
R5214 T19110 T19107 conj expression,deficiencies
R5215 T19111 T19107 prep of,deficiencies
R5216 T19112 T19113 nmod platelet,proteins
R5218 T19113 T19111 pobj proteins,of
R5219 T19114 T19112 cc and,platelet
R5221 T19115 T19112 conj coagulation,platelet
R5222 T19116 T19107 prep in,deficiencies
R5223 T19117 T19116 pobj mice,in
R5225 T19118 T19096 punct .,used
R5226 T19120 T19121 nsubj Sweeny,screened
R5228 T19122 T19123 advmod et,al
R5229 T19123 T19120 advmod al,Sweeny
R5231 T19124 T19125 punct [,28
R5232 T19125 T19120 parataxis 28,Sweeny
R5233 T19126 T19125 punct ],28
R5235 T19127 T19128 nummod 25,strains
R5236 T19128 T19121 dobj strains,screened
R5238 T19129 T19128 prep of,strains
R5239 T19130 T19129 pobj mice,of
R5240 T19131 T19121 cc and,screened
R5242 T19132 T19121 conj found,screened
R5243 T19133 T19134 advmod only,mice
R5245 T19134 T19139 nsubj mice,have
R5246 T19135 T19134 det the,mice
R5247 T19136 T19137 compound RIIS,J
R5249 T19137 T19134 compound J,mice
R5250 T19138 T19137 punct /,J
R5251 T19139 T19132 ccomp have,found
R5252 T19140 T19139 aux to,have
R5253 T19141 T19142 amod increased,time
R5254 T19142 T19139 dobj time,have
R5256 T19143 T19142 compound bleeding,time
R5257 T19144 T19142 prep due,time
R5258 T19145 T19144 pcomp to,due
R5260 T19146 T19147 amod reduced,antigen
R5261 T19147 T19144 pobj antigen,due
R5263 T19148 T19149 compound von,Willebrand
R5264 T19149 T19147 compound Willebrand,antigen
R5265 T19150 T19121 punct .,screened
R5267 T19152 T19153 nsubj Broze,evaluated
R5269 T19154 T19155 advmod et,al
R5270 T19155 T19152 advmod al,Broze
R5272 T19156 T19157 punct [,29
R5273 T19157 T19152 parataxis 29,Broze
R5275 T19158 T19157 punct ],29
R5276 T19159 T19153 dobj mice,evaluated
R5277 T19160 T19159 prep with,mice
R5279 T19161 T19162 compound gene,deletions
R5280 T19162 T19160 pobj deletions,with
R5281 T19163 T19162 prep of,deletions
R5283 T19164 T19165 det the,pathway
R5284 T19165 T19163 pobj pathway,of
R5285 T19166 T19165 compound coagulation,pathway
R5286 T19167 T19153 cc and,evaluated
R5288 T19168 T19153 conj found,evaluated
R5289 T19169 T19170 mark that,persisted
R5290 T19170 T19168 ccomp persisted,found
R5291 T19171 T19172 mark while,increased
R5293 T19172 T19170 advcl increased,persisted
R5294 T19173 T19174 compound bleeding,time
R5296 T19174 T19172 nsubjpass time,increased
R5297 T19175 T19172 auxpass was,increased
R5298 T19176 T19172 neg not,increased
R5300 T19177 T19170 punct ", ",persisted
R5301 T19178 T19170 nsubj rebleeding,persisted
R5303 T19179 T19170 prep despite,persisted
R5304 T19180 T19179 pobj electrocautery,despite
R5308 T19181 T19180 prep of,electrocautery
R5309 T19182 T19183 det the,tail
R5312 T19183 T19181 pobj tail,of
R5314 T19184 T19170 prep in,persisted
R5315 T19185 T19186 npadvmod FVIII,deficient
R5316 T19186 T19189 amod deficient,mice
R5318 T19187 T19185 cc and,FVIII
R5319 T19188 T19185 conj FIX,FVIII
R5320 T19189 T19184 pobj mice,in
R5322 T19190 T19153 punct .,evaluated
R5324 T19192 T19193 det This,observation
R5325 T19193 T19194 nsubj observation,raised
R5327 T19195 T19196 det the,possibility
R5329 T19196 T19194 dobj possibility,raised
R5330 T19197 T19198 mark that,be
R5331 T19198 T19196 acl be,possibility
R5333 T19199 T19200 compound rebleeding,time
R5334 T19200 T19198 nsubj time,be
R5335 T19201 T19198 aux may,be
R5337 T19202 T19203 det a,reporter
R5338 T19203 T19198 attr reporter,be
R5339 T19204 T19203 amod sensitive,reporter
R5341 T19205 T19203 prep of,reporter
R5342 T19206 T19207 amod genetic,influences
R5343 T19207 T19205 pobj influences,of
R5345 T19208 T19207 prep on,influences
R5346 T19209 T19210 compound thrombus,formation
R5347 T19210 T19208 pobj formation,on
R5349 T19211 T19210 cc and,formation
R5350 T19212 T19210 conj stability,formation
R5351 T19213 T19194 punct .,raised
R5353 T19215 T19216 nsubj Mice,increased
R5355 T19217 T19218 dep that,are
R5356 T19218 T19215 relcl are,Mice
R5357 T19219 T19218 acomp deficient,are
R5358 T19220 T19219 prep in,deficient
R5359 T19221 T19220 pobj factors,in
R5360 T19222 T19221 acl required,factors
R5362 T19223 T19222 prep for,required
R5363 T19224 T19225 amod normal,function
R5364 T19225 T19223 pobj function,for
R5366 T19226 T19225 compound platelet,function
R5367 T19227 T19225 punct ", ",function
R5368 T19228 T19229 compound platelet,Ib
R5370 T19229 T19225 conj Ib,function
R5371 T19230 T19229 compound glycoprotein,Ib
R5372 T19231 T19232 punct [,30
R5374 T19232 T19229 parataxis 30,Ib
R5376 T19233 T19232 punct ],30
R5377 T19234 T19229 punct ", ",Ib
R5378 T19235 T19229 cc and,Ib
R5379 T19236 T19237 npadvmod protease,activated
R5381 T19237 T19239 amod activated,receptor
R5382 T19238 T19237 punct -,activated
R5384 T19239 T19229 conj receptor,Ib
R5385 T19240 T19239 punct -,receptor
R5386 T19241 T19239 nummod 4,receptor
R5388 T19242 T19222 punct ", ",required
R5389 T19243 T19244 punct [,31
R5390 T19244 T19222 parataxis 31,required
R5392 T19245 T19244 punct ],31
R5393 T19246 T19216 aux have,increased
R5394 T19247 T19248 compound tail,bleeding
R5396 T19248 T19249 compound bleeding,time
R5397 T19249 T19216 dobj time,increased
R5398 T19250 T19216 punct .,increased
R5400 T19252 T19253 det The,deficiency
R5401 T19253 T19255 nsubj deficiency,shows
R5403 T19254 T19253 compound leptin,deficiency
R5404 T19256 T19253 prep with,deficiency
R5406 T19257 T19258 amod reduced,aggregation
R5407 T19258 T19256 pobj aggregation,with
R5408 T19259 T19258 compound platelet,aggregation
R5409 T19260 T19255 advmod clearly,shows
R5410 T19261 T19262 det a,increase
R5411 T19262 T19255 dobj increase,shows
R5413 T19263 T19262 amod marked,increase
R5414 T19264 T19262 prep in,increase
R5415 T19265 T19266 compound bleeding,time
R5416 T19266 T19264 pobj time,in
R5418 T19267 T19255 cc and,shows
R5419 T19268 T19269 det the,time
R5422 T19269 T19272 nsubj time,suggests
R5423 T19270 T19269 amod increased,time
R5425 T19271 T19269 compound bleeding,time
R5426 T19272 T19255 conj suggests,shows
R5428 T19273 T19269 prep in,time
R5430 T19274 T19275 nmod Plg,mice
R5431 T19275 T19273 pobj mice,in
R5432 T19276 T19274 punct -,Plg
R5433 T19277 T19274 punct /,Plg
R5434 T19287 T19286 cc and,Plg
R5435 T19278 T19274 punct -,Plg
R5436 T19279 T19274 cc and,Plg
R5437 T19280 T19274 conj uPA,Plg
R5438 T19288 T19286 conj uPA,Plg
R5439 T19281 T19280 punct -,uPA
R5440 T19282 T19280 punct /,uPA
R5441 T19283 T19280 punct -,uPA
R5442 T19289 T19285 aux may,exert
R5443 T19284 T19285 mark that,exert
R5444 T19285 T19272 ccomp exert,suggests
R5445 T19286 T19285 nsubj Plg,exert
R5446 T19290 T19291 det an,influence
R5447 T19291 T19285 dobj influence,exert
R5448 T19292 T19291 prep on,influence
R5449 T19293 T19294 compound platelet,response
R5451 T19294 T19292 pobj response,on
R5454 T19295 T19296 aux to,promote
R5458 T19296 T19285 advcl promote,exert
R5462 T19297 T19298 amod normal,formation
R5466 T19298 T19296 dobj formation,promote
R5470 T19299 T19298 compound thrombus,formation
R5474 T19300 T19272 punct .,suggests
R5478 T19302 T19303 advmod Overall,suggests
R5483 T19304 T19303 punct ", ",suggests
R5486 T19305 T19306 det the,increase
R5490 T19306 T19303 nsubj increase,suggests
R5493 T19307 T19306 amod marked,increase
R5497 T19308 T19306 prep in,increase
R5501 T19309 T19310 compound rebleeding,times
R5504 T19310 T19308 pobj times,in
R5507 T19311 T19306 acl observed,increase
R5509 T19312 T19311 prep in,observed
R5515 T19313 T19314 amod certain,strains
R5518 T19314 T19312 pobj strains,in
R5521 T19315 T19314 compound mouse,strains
R5525 T19316 T19317 amod genetic,factors
R5528 T19317 T19318 nsubj factors,play
R5529 T19318 T19303 advcl play,suggests
R5531 T19319 T19317 amod other,factors
R5535 T19320 T19319 prep than,other
R5538 T19321 T19320 pobj coagulation,than
R5542 T19322 T19318 aux may,play
R5546 T19323 T19324 det a,role
R5550 T19324 T19318 dobj role,play
R5554 T19325 T19318 prep in,play
R5558 T19326 T19327 det the,stability
R5562 T19327 T19325 pobj stability,in
R5569 T19328 T19327 prep of,stability
R5574 T19329 T19330 det a,thrombus
R5578 T19330 T19328 pobj thrombus,of
R5581 T19331 T19303 punct .,suggests