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PMC:1617083 / 2582-3933 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3130 0-6 NN denotes Family
T3131 7-14 NN denotes history
T3133 15-16 -LRB- denotes [
T3134 16-17 CD denotes 1
T3135 17-18 -RRB- denotes ]
T3132 19-21 VBZ denotes is
T3136 22-25 DT denotes the
T3138 26-35 JJS denotes strongest
T3139 36-40 NN denotes risk
T3137 41-47 NN denotes factor
T3140 48-51 IN denotes for
T3141 52-66 JJ denotes cardiovascular
T3142 67-75 NNS denotes diseases
T3143 76-77 -LRB- denotes (
T3144 77-80 NNS denotes CVD
T3145 80-81 -RRB- denotes )
T3146 81-82 . denotes .
T3147 82-215 sentence denotes While a number of genetic mutations have been identified, these account for only a small percentage of the CVD in human populations.
T3148 83-88 IN denotes While
T3150 89-90 DT denotes a
T3151 91-97 NN denotes number
T3152 98-100 IN denotes of
T3153 101-108 JJ denotes genetic
T3154 109-118 NNS denotes mutations
T3155 119-123 VBP denotes have
T3156 124-128 VBN denotes been
T3149 129-139 VBN denotes identified
T3158 139-141 , denotes ,
T3159 141-146 DT denotes these
T3157 147-154 VBP denotes account
T3160 155-158 IN denotes for
T3161 159-163 RB denotes only
T3163 164-165 DT denotes a
T3164 166-171 JJ denotes small
T3162 172-182 NN denotes percentage
T3165 183-185 IN denotes of
T3166 186-189 DT denotes the
T3167 190-193 NNS denotes CVD
T3168 194-196 IN denotes in
T3169 197-202 JJ denotes human
T3170 203-214 NNS denotes populations
T3171 214-215 . denotes .
T3172 215-460 sentence denotes Thrombus formation on fissured atherosclerotic plaques is the precipitating event in the transition from a stable or subclinical atherosclerotic disease and leads to acute myocardial infarction, ischemic stroke or peripheral arterial occlusion.
T3173 216-224 NN denotes Thrombus
T3174 225-234 NN denotes formation
T3176 235-237 IN denotes on
T3177 238-246 VBN denotes fissured
T3179 247-262 JJ denotes atherosclerotic
T3178 263-270 NNS denotes plaques
T3175 271-273 VBZ denotes is
T3180 274-277 DT denotes the
T3182 278-291 VBG denotes precipitating
T3181 292-297 NN denotes event
T3183 298-300 IN denotes in
T3184 301-304 DT denotes the
T3185 305-315 NN denotes transition
T3186 316-320 IN denotes from
T3187 321-322 DT denotes a
T3189 323-329 JJ denotes stable
T3190 330-332 CC denotes or
T3191 333-344 JJ denotes subclinical
T3192 345-360 JJ denotes atherosclerotic
T3188 361-368 NN denotes disease
T3193 369-372 CC denotes and
T3194 373-378 VBZ denotes leads
T3195 379-381 IN denotes to
T3196 382-387 JJ denotes acute
T3198 388-398 JJ denotes myocardial
T3197 399-409 NN denotes infarction
T3199 409-411 , denotes ,
T3200 411-419 JJ denotes ischemic
T3201 420-426 NN denotes stroke
T3202 427-429 CC denotes or
T3203 430-440 JJ denotes peripheral
T3204 441-449 JJ denotes arterial
T3205 450-459 NN denotes occlusion
T3206 459-460 . denotes .
T3207 460-585 sentence denotes Arterial and venous thrombosis are complex responses and are influenced by multiple genetic and environmental factors [2-5].
T3208 461-469 JJ denotes Arterial
T3210 470-473 CC denotes and
T3211 474-480 JJ denotes venous
T3209 481-491 NN denotes thrombosis
T3212 492-495 VBP denotes are
T3213 496-503 JJ denotes complex
T3214 504-513 NNS denotes responses
T3215 514-517 CC denotes and
T3216 518-521 VBP denotes are
T3217 522-532 VBN denotes influenced
T3218 533-535 IN denotes by
T3219 536-544 JJ denotes multiple
T3221 545-552 JJ denotes genetic
T3222 553-556 CC denotes and
T3223 557-570 JJ denotes environmental
T3220 571-578 NNS denotes factors
T3224 579-580 -LRB- denotes [
T3225 580-581 CD denotes 2
T3226 581-582 SYM denotes -
T3227 582-583 CD denotes 5
T3228 583-584 -RRB- denotes ]
T3229 584-585 . denotes .
T3230 585-867 sentence denotes Polymorphisms and mutations in coagulation factors, fibrinolytic factors, platelet surface receptors, methylenetetrahydrofalate reductase, endothelial nitric oxide synthase, and antioxidant enzymes have been implicated as genetic determinants of susceptibility to thrombosis [6,7].
T3231 586-599 NNS denotes Polymorphisms
T3233 600-603 CC denotes and
T3234 604-613 NNS denotes mutations
T3235 614-616 IN denotes in
T3236 617-628 NN denotes coagulation
T3237 629-636 NNS denotes factors
T3238 636-638 , denotes ,
T3239 638-650 JJ denotes fibrinolytic
T3240 651-658 NNS denotes factors
T3241 658-660 , denotes ,
T3242 660-668 NN denotes platelet
T3243 669-676 NN denotes surface
T3244 677-686 NNS denotes receptors
T3245 686-688 , denotes ,
T3246 688-713 NN denotes methylenetetrahydrofalate
T3247 714-723 NN denotes reductase
T3248 723-725 , denotes ,
T3249 725-736 JJ denotes endothelial
T3251 737-743 JJ denotes nitric
T3252 744-749 NN denotes oxide
T3250 750-758 NN denotes synthase
T3253 758-760 , denotes ,
T3254 760-763 CC denotes and
T3255 764-775 JJ denotes antioxidant
T3256 776-783 NNS denotes enzymes
T3257 784-788 VBP denotes have
T3258 789-793 VBN denotes been
T3232 794-804 VBN denotes implicated
T3259 805-807 IN denotes as
T3260 808-815 JJ denotes genetic
T3261 816-828 NNS denotes determinants
T3262 829-831 IN denotes of
T3263 832-846 NN denotes susceptibility
T3264 847-849 IN denotes to
T3265 850-860 NN denotes thrombosis
T3266 861-862 -LRB- denotes [
T3268 862-863 CD denotes 6
T3269 863-864 , denotes ,
T3267 864-865 CD denotes 7
T3270 865-866 -RRB- denotes ]
T3271 866-867 . denotes .
T3272 867-961 sentence denotes Great strides have been made in the diagnosis and treatment of thrombosis in the last decade.
T3273 868-873 JJ denotes Great
T3274 874-881 NNS denotes strides
T3276 882-886 VBP denotes have
T3277 887-891 VBN denotes been
T3275 892-896 VBN denotes made
T3278 897-899 IN denotes in
T3279 900-903 DT denotes the
T3280 904-913 NN denotes diagnosis
T3281 914-917 CC denotes and
T3282 918-927 NN denotes treatment
T3283 928-930 IN denotes of
T3284 931-941 NN denotes thrombosis
T3285 942-944 IN denotes in
T3286 945-948 DT denotes the
T3288 949-953 JJ denotes last
T3287 954-960 NN denotes decade
T3289 960-961 . denotes .
T3290 961-1141 sentence denotes However, strategies to prevent thrombosis have lagged far behind due, in part, to the contribution of multiple, and as yet undefined, genetic factors that lead to thrombotic risk.
T3291 962-969 RB denotes However
T3293 969-971 , denotes ,
T3294 971-981 NNS denotes strategies
T3295 982-984 TO denotes to
T3296 985-992 VB denotes prevent
T3297 993-1003 NN denotes thrombosis
T3298 1004-1008 VBP denotes have
T3292 1009-1015 VBN denotes lagged
T3299 1016-1019 RB denotes far
T3300 1020-1026 RB denotes behind
T3301 1027-1030 IN denotes due
T3302 1030-1032 , denotes ,
T3303 1032-1034 IN denotes in
T3304 1035-1039 JJ denotes part
T3305 1039-1041 , denotes ,
T3306 1041-1043 IN denotes to
T3307 1044-1047 DT denotes the
T3308 1048-1060 NN denotes contribution
T3309 1061-1063 IN denotes of
T3310 1064-1072 JJ denotes multiple
T3312 1072-1074 , denotes ,
T3313 1074-1077 CC denotes and
T3314 1078-1080 RB denotes as
T3315 1081-1084 RB denotes yet
T3316 1085-1094 JJ denotes undefined
T3317 1094-1096 , denotes ,
T3318 1096-1103 JJ denotes genetic
T3311 1104-1111 NNS denotes factors
T3319 1112-1116 WDT denotes that
T3320 1117-1121 VBP denotes lead
T3321 1122-1124 IN denotes to
T3322 1125-1135 JJ denotes thrombotic
T3323 1136-1140 NN denotes risk
T3324 1140-1141 . denotes .
T3325 1141-1351 sentence denotes Moreover, it remains unclear how genetic background influences the function of molecules and pathways known to regulate thrombus formation and lysis and, thereby, contributes to the risk of thrombotic disease.
T3326 1142-1150 RB denotes Moreover
T3328 1150-1152 , denotes ,
T3329 1152-1154 PRP denotes it
T3327 1155-1162 VBZ denotes remains
T3330 1163-1170 JJ denotes unclear
T3331 1171-1174 WRB denotes how
T3333 1175-1182 JJ denotes genetic
T3334 1183-1193 NN denotes background
T3332 1194-1204 VBZ denotes influences
T3335 1205-1208 DT denotes the
T3336 1209-1217 NN denotes function
T3337 1218-1220 IN denotes of
T3338 1221-1230 NNS denotes molecules
T3339 1231-1234 CC denotes and
T3340 1235-1243 NNS denotes pathways
T3341 1244-1249 VBN denotes known
T3342 1250-1252 TO denotes to
T3343 1253-1261 VB denotes regulate
T3344 1262-1270 NN denotes thrombus
T3345 1271-1280 NN denotes formation
T3346 1281-1284 CC denotes and
T3347 1285-1290 NN denotes lysis
T3348 1291-1294 CC denotes and
T3349 1294-1296 , denotes ,
T3350 1296-1303 RB denotes thereby
T3352 1303-1305 , denotes ,
T3351 1305-1316 VBZ denotes contributes
T3353 1317-1319 IN denotes to
T3354 1320-1323 DT denotes the
T3355 1324-1328 NN denotes risk
T3356 1329-1331 IN denotes of
T3357 1332-1342 JJ denotes thrombotic
T3358 1343-1350 NN denotes disease
T3359 1350-1351 . denotes .
R456 T3130 T3131 compound Family,history
R457 T3131 T3132 nsubj history,is
R458 T3133 T3134 punct [,1
R459 T3134 T3131 parataxis 1,history
R460 T3135 T3134 punct ],1
R461 T3136 T3137 det the,factor
R462 T3137 T3132 attr factor,is
R463 T3138 T3137 amod strongest,factor
R464 T3139 T3137 compound risk,factor
R465 T3140 T3137 prep for,factor
R466 T3141 T3142 amod cardiovascular,diseases
R467 T3142 T3140 pobj diseases,for
R468 T3143 T3142 punct (,diseases
R469 T3144 T3142 appos CVD,diseases
R470 T3145 T3132 punct ),is
R471 T3146 T3132 punct .,is
R472 T3148 T3149 mark While,identified
R473 T3149 T3157 advcl identified,account
R474 T3150 T3151 det a,number
R475 T3151 T3149 nsubjpass number,identified
R476 T3152 T3151 prep of,number
R477 T3153 T3154 amod genetic,mutations
R478 T3154 T3152 pobj mutations,of
R479 T3155 T3149 aux have,identified
R480 T3156 T3149 auxpass been,identified
R481 T3158 T3157 punct ", ",account
R482 T3159 T3157 nsubj these,account
R483 T3160 T3157 prep for,account
R484 T3161 T3162 advmod only,percentage
R485 T3162 T3160 pobj percentage,for
R486 T3163 T3162 det a,percentage
R487 T3164 T3162 amod small,percentage
R488 T3165 T3162 prep of,percentage
R489 T3166 T3167 det the,CVD
R490 T3167 T3165 pobj CVD,of
R491 T3168 T3167 prep in,CVD
R492 T3169 T3170 amod human,populations
R493 T3170 T3168 pobj populations,in
R494 T3171 T3157 punct .,account
R495 T3173 T3174 compound Thrombus,formation
R496 T3174 T3175 nsubj formation,is
R497 T3176 T3174 prep on,formation
R498 T3177 T3178 amod fissured,plaques
R499 T3178 T3176 pobj plaques,on
R500 T3179 T3178 amod atherosclerotic,plaques
R501 T3180 T3181 det the,event
R502 T3181 T3175 attr event,is
R503 T3182 T3181 amod precipitating,event
R504 T3183 T3181 prep in,event
R505 T3184 T3185 det the,transition
R506 T3185 T3183 pobj transition,in
R507 T3186 T3185 prep from,transition
R508 T3187 T3188 det a,disease
R509 T3188 T3186 pobj disease,from
R510 T3189 T3188 amod stable,disease
R511 T3190 T3189 cc or,stable
R512 T3191 T3189 conj subclinical,stable
R513 T3192 T3188 amod atherosclerotic,disease
R514 T3193 T3175 cc and,is
R515 T3194 T3175 conj leads,is
R516 T3195 T3194 prep to,leads
R517 T3196 T3197 amod acute,infarction
R518 T3197 T3195 pobj infarction,to
R519 T3198 T3197 amod myocardial,infarction
R520 T3199 T3197 punct ", ",infarction
R521 T3200 T3201 amod ischemic,stroke
R522 T3201 T3197 conj stroke,infarction
R523 T3202 T3201 cc or,stroke
R524 T3203 T3204 amod peripheral,arterial
R525 T3204 T3205 amod arterial,occlusion
R526 T3205 T3201 conj occlusion,stroke
R527 T3206 T3175 punct .,is
R528 T3208 T3209 amod Arterial,thrombosis
R529 T3209 T3212 nsubj thrombosis,are
R530 T3210 T3208 cc and,Arterial
R531 T3211 T3208 conj venous,Arterial
R532 T3213 T3214 amod complex,responses
R533 T3214 T3212 attr responses,are
R534 T3215 T3212 cc and,are
R535 T3216 T3217 auxpass are,influenced
R536 T3217 T3212 conj influenced,are
R537 T3218 T3217 agent by,influenced
R538 T3219 T3220 amod multiple,factors
R539 T3220 T3218 pobj factors,by
R540 T3221 T3220 amod genetic,factors
R541 T3222 T3221 cc and,genetic
R542 T3223 T3221 conj environmental,genetic
R543 T3224 T3225 punct [,2
R544 T3225 T3217 parataxis 2,influenced
R545 T3226 T3227 punct -,5
R546 T3227 T3225 prep 5,2
R547 T3228 T3225 punct ],2
R548 T3229 T3212 punct .,are
R549 T3231 T3232 nsubjpass Polymorphisms,implicated
R550 T3233 T3231 cc and,Polymorphisms
R551 T3234 T3231 conj mutations,Polymorphisms
R552 T3235 T3231 prep in,Polymorphisms
R553 T3236 T3237 compound coagulation,factors
R554 T3237 T3235 pobj factors,in
R555 T3238 T3237 punct ", ",factors
R556 T3239 T3240 amod fibrinolytic,factors
R557 T3240 T3237 conj factors,factors
R558 T3241 T3240 punct ", ",factors
R559 T3242 T3243 compound platelet,surface
R560 T3243 T3244 compound surface,receptors
R561 T3244 T3240 conj receptors,factors
R562 T3245 T3244 punct ", ",receptors
R563 T3246 T3247 compound methylenetetrahydrofalate,reductase
R564 T3247 T3244 conj reductase,receptors
R565 T3248 T3247 punct ", ",reductase
R566 T3249 T3250 amod endothelial,synthase
R567 T3250 T3247 conj synthase,reductase
R568 T3251 T3252 amod nitric,oxide
R569 T3252 T3250 compound oxide,synthase
R570 T3253 T3250 punct ", ",synthase
R571 T3254 T3250 cc and,synthase
R572 T3255 T3256 amod antioxidant,enzymes
R573 T3256 T3250 conj enzymes,synthase
R574 T3257 T3232 aux have,implicated
R575 T3258 T3232 auxpass been,implicated
R576 T3259 T3232 prep as,implicated
R577 T3260 T3261 amod genetic,determinants
R578 T3261 T3259 pobj determinants,as
R579 T3262 T3261 prep of,determinants
R580 T3263 T3262 pobj susceptibility,of
R581 T3264 T3263 prep to,susceptibility
R582 T3265 T3264 pobj thrombosis,to
R583 T3266 T3267 punct [,7
R584 T3267 T3232 parataxis 7,implicated
R585 T3268 T3267 nummod 6,7
R586 T3269 T3267 punct ",",7
R587 T3270 T3267 punct ],7
R588 T3271 T3232 punct .,implicated
R589 T3273 T3274 amod Great,strides
R590 T3274 T3275 nsubjpass strides,made
R591 T3276 T3275 aux have,made
R592 T3277 T3275 auxpass been,made
R593 T3278 T3275 prep in,made
R594 T3279 T3280 det the,diagnosis
R595 T3280 T3278 pobj diagnosis,in
R596 T3281 T3280 cc and,diagnosis
R597 T3282 T3280 conj treatment,diagnosis
R598 T3283 T3280 prep of,diagnosis
R599 T3284 T3283 pobj thrombosis,of
R600 T3285 T3275 prep in,made
R601 T3286 T3287 det the,decade
R602 T3287 T3285 pobj decade,in
R603 T3288 T3287 amod last,decade
R604 T3289 T3275 punct .,made
R605 T3291 T3292 advmod However,lagged
R606 T3293 T3292 punct ", ",lagged
R607 T3294 T3292 nsubj strategies,lagged
R608 T3295 T3296 aux to,prevent
R609 T3296 T3294 advcl prevent,strategies
R610 T3297 T3296 dobj thrombosis,prevent
R611 T3298 T3292 aux have,lagged
R612 T3299 T3300 advmod far,behind
R613 T3300 T3292 advmod behind,lagged
R614 T3301 T3292 prep due,lagged
R615 T3302 T3301 punct ", ",due
R616 T3303 T3301 prep in,due
R617 T3304 T3303 amod part,in
R618 T3305 T3301 punct ", ",due
R619 T3306 T3301 pcomp to,due
R620 T3307 T3308 det the,contribution
R621 T3308 T3301 pobj contribution,due
R622 T3309 T3308 prep of,contribution
R623 T3310 T3311 amod multiple,factors
R624 T3311 T3309 pobj factors,of
R625 T3312 T3310 punct ", ",multiple
R626 T3313 T3310 cc and,multiple
R627 T3314 T3315 advmod as,yet
R628 T3315 T3316 advmod yet,undefined
R629 T3316 T3310 conj undefined,multiple
R630 T3317 T3311 punct ", ",factors
R631 T3318 T3311 amod genetic,factors
R632 T3319 T3320 dep that,lead
R633 T3320 T3311 relcl lead,factors
R634 T3321 T3320 prep to,lead
R635 T3322 T3323 amod thrombotic,risk
R636 T3323 T3321 pobj risk,to
R637 T3324 T3292 punct .,lagged
R638 T3326 T3327 advmod Moreover,remains
R639 T3328 T3327 punct ", ",remains
R640 T3329 T3327 nsubj it,remains
R641 T3330 T3327 oprd unclear,remains
R642 T3331 T3332 advmod how,influences
R643 T3332 T3327 ccomp influences,remains
R644 T3333 T3334 amod genetic,background
R645 T3334 T3332 nsubj background,influences
R646 T3335 T3336 det the,function
R647 T3336 T3332 dobj function,influences
R648 T3337 T3336 prep of,function
R649 T3338 T3337 pobj molecules,of
R650 T3339 T3338 cc and,molecules
R651 T3340 T3338 conj pathways,molecules
R652 T3341 T3338 acl known,molecules
R653 T3342 T3343 aux to,regulate
R654 T3343 T3341 xcomp regulate,known
R655 T3344 T3345 compound thrombus,formation
R656 T3345 T3343 dobj formation,regulate
R657 T3346 T3345 cc and,formation
R658 T3347 T3345 conj lysis,formation
R659 T3348 T3332 cc and,influences
R660 T3349 T3332 punct ", ",influences
R661 T3350 T3351 advmod thereby,contributes
R662 T3351 T3332 conj contributes,influences
R663 T3352 T3351 punct ", ",contributes
R664 T3353 T3351 prep to,contributes
R665 T3354 T3355 det the,risk
R666 T3355 T3353 pobj risk,to
R667 T3356 T3355 prep of,risk
R668 T3357 T3358 amod thrombotic,disease
R669 T3358 T3356 pobj disease,of
R670 T3359 T3327 punct .,remains