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PMC:1564426 / 5734-6560 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2909 0-2 TO denotes To
T2910 3-9 VB denotes assess
T2912 10-13 DT denotes the
T2913 14-18 NN denotes role
T2914 19-21 IN denotes of
T2915 22-25 NN denotes Apc
T2916 26-28 IN denotes in
T2917 29-38 JJ denotes different
T2918 39-45 NNS denotes stages
T2919 46-48 IN denotes of
T2920 49-53 NN denotes life
T2921 54-68 RB denotes systematically
T2922 68-70 , denotes ,
T2923 70-72 PRP denotes we
T2911 73-82 VBD denotes generated
T2924 83-87 NNS denotes mice
T2925 88-98 VBG denotes containing
T2926 99-100 DT denotes a
T2928 101-112 JJ denotes conditional
T2929 113-121 NN denotes knockout
T2930 122-123 -LRB- denotes (
T2931 123-126 NN denotes CKO
T2932 126-127 -RRB- denotes )
T2933 128-134 JJ denotes mutant
T2927 135-141 NN denotes allele
T2934 142-144 IN denotes of
T2935 145-148 NN denotes Apc
T2936 149-150 -LRB- denotes (
T2937 150-156 NN denotes ApcCKO
T2938 156-157 -RRB- denotes )
T2939 157-158 . denotes .
T2940 158-353 sentence denotes These mice were mated with a strain carrying Cre recombinase under the control of the human Keratin 14 (K14) promoter, which is active in basal cells of epidermis and other stratified epithelia.
T2941 159-164 DT denotes These
T2942 165-169 NNS denotes mice
T2944 170-174 VBD denotes were
T2943 175-180 VBN denotes mated
T2945 181-185 IN denotes with
T2946 186-187 DT denotes a
T2947 188-194 NN denotes strain
T2948 195-203 VBG denotes carrying
T2949 204-207 NN denotes Cre
T2950 208-219 NN denotes recombinase
T2951 220-225 IN denotes under
T2952 226-229 DT denotes the
T2953 230-237 NN denotes control
T2954 238-240 IN denotes of
T2955 241-244 DT denotes the
T2957 245-250 JJ denotes human
T2958 251-258 NN denotes Keratin
T2959 259-261 CD denotes 14
T2960 262-263 -LRB- denotes (
T2961 263-266 NN denotes K14
T2962 266-267 -RRB- denotes )
T2956 268-276 NN denotes promoter
T2963 276-278 , denotes ,
T2964 278-283 WDT denotes which
T2965 284-286 VBZ denotes is
T2966 287-293 JJ denotes active
T2967 294-296 IN denotes in
T2968 297-302 JJ denotes basal
T2969 303-308 NNS denotes cells
T2970 309-311 IN denotes of
T2971 312-321 NN denotes epidermis
T2972 322-325 CC denotes and
T2973 326-331 JJ denotes other
T2975 332-342 JJ denotes stratified
T2974 343-352 NNS denotes epithelia
T2976 352-353 . denotes .
T2977 353-600 sentence denotes We report here that K14 promoter-driven loss of Apc resulted in aberrant development of several organs that require inductive epithelial–mesenchymal interactions, including hair follicle, teeth, and thymus, and resulted in neonatal death in mice.
T2978 354-356 PRP denotes We
T2979 357-363 VBP denotes report
T2980 364-368 RB denotes here
T2981 369-373 IN denotes that
T2983 374-377 NN denotes K14
T2984 378-386 NN denotes promoter
T2986 386-387 HYPH denotes -
T2985 387-393 VBN denotes driven
T2987 394-398 NN denotes loss
T2988 399-401 IN denotes of
T2989 402-405 NN denotes Apc
T2982 406-414 VBD denotes resulted
T2990 415-417 IN denotes in
T2991 418-426 JJ denotes aberrant
T2992 427-438 NN denotes development
T2993 439-441 IN denotes of
T2994 442-449 JJ denotes several
T2995 450-456 NNS denotes organs
T2996 457-461 WDT denotes that
T2997 462-469 VBP denotes require
T2998 470-479 JJ denotes inductive
T3000 480-490 JJ denotes epithelial
T3002 490-491 HYPH denotes –
T3001 491-502 JJ denotes mesenchymal
T2999 503-515 NNS denotes interactions
T3003 515-517 , denotes ,
T3004 517-526 VBG denotes including
T3005 527-531 NN denotes hair
T3006 532-540 NN denotes follicle
T3007 540-542 , denotes ,
T3008 542-547 NNS denotes teeth
T3009 547-549 , denotes ,
T3010 549-552 CC denotes and
T3011 553-559 NN denotes thymus
T3012 559-561 , denotes ,
T3013 561-564 CC denotes and
T3014 565-573 VBD denotes resulted
T3015 574-576 IN denotes in
T3016 577-585 JJ denotes neonatal
T3017 586-591 NN denotes death
T3018 592-594 IN denotes in
T3019 595-599 NNS denotes mice
T3020 599-600 . denotes .
T3021 600-826 sentence denotes We found that Apc plays a crucial role in determinations of cell fates during the embryonic development, possibly via temporal and tissue-specific regulation of β-catenin levels in the skin, its appendages, and in the thymus.
T3022 601-603 PRP denotes We
T3023 604-609 VBD denotes found
T3024 610-614 IN denotes that
T3026 615-618 NN denotes Apc
T3025 619-624 VBZ denotes plays
T3027 625-626 DT denotes a
T3029 627-634 JJ denotes crucial
T3028 635-639 NN denotes role
T3030 640-642 IN denotes in
T3031 643-657 NNS denotes determinations
T3032 658-660 IN denotes of
T3033 661-665 NN denotes cell
T3034 666-671 NNS denotes fates
T3035 672-678 IN denotes during
T3036 679-682 DT denotes the
T3038 683-692 JJ denotes embryonic
T3037 693-704 NN denotes development
T3039 704-706 , denotes ,
T3040 706-714 RB denotes possibly
T3041 715-718 IN denotes via
T3042 719-727 JJ denotes temporal
T3044 728-731 CC denotes and
T3045 732-738 NN denotes tissue
T3047 738-739 HYPH denotes -
T3046 739-747 JJ denotes specific
T3043 748-758 NN denotes regulation
T3048 759-761 IN denotes of
T3049 762-763 NN denotes β
T3051 763-764 HYPH denotes -
T3050 764-771 NN denotes catenin
T3052 772-778 NNS denotes levels
T3053 779-781 IN denotes in
T3054 782-785 DT denotes the
T3055 786-790 NN denotes skin
T3056 790-792 , denotes ,
T3057 792-795 PRP$ denotes its
T3058 796-806 NNS denotes appendages
T3059 806-808 , denotes ,
T3060 808-811 CC denotes and
T3061 812-814 IN denotes in
T3062 815-818 DT denotes the
T3063 819-825 NN denotes thymus
T3064 825-826 . denotes .
R709 T2923 T2911 nsubj we,generated
R710 T2924 T2911 dobj mice,generated
R711 T2925 T2924 acl containing,mice
R713 T2926 T2927 det a,allele
R715 T2927 T2925 dobj allele,containing
R716 T2928 T2929 amod conditional,knockout
R717 T2929 T2927 nmod knockout,allele
R718 T2930 T2929 punct (,knockout
R720 T2931 T2929 appos CKO,knockout
R721 T2932 T2927 punct ),allele
R723 T2933 T2927 amod mutant,allele
R724 T2934 T2927 prep of,allele
R725 T2935 T2934 pobj Apc,of
R727 T2936 T2927 punct (,allele
R728 T2937 T2927 appos ApcCKO,allele
R729 T2938 T2911 punct ),generated
R730 T2939 T2911 punct .,generated
R732 T2941 T2942 det These,mice
R734 T2942 T2943 nsubjpass mice,mated
R735 T2944 T2943 auxpass were,mated
R737 T2945 T2943 prep with,mated
R738 T2946 T2947 det a,strain
R739 T2947 T2945 pobj strain,with
R740 T2948 T2947 acl carrying,strain
R742 T2949 T2950 compound Cre,recombinase
R743 T2950 T2948 dobj recombinase,carrying
R745 T2951 T2950 prep under,recombinase
R747 T2952 T2953 det the,control
R748 T2953 T2951 pobj control,under
R749 T2954 T2953 prep of,control
R750 T2955 T2956 det the,promoter
R752 T2956 T2954 pobj promoter,of
R753 T2957 T2956 amod human,promoter
R754 T2958 T2956 nmod Keratin,promoter
R756 T2959 T2958 nummod 14,Keratin
R757 T2960 T2958 punct (,Keratin
R758 T2961 T2958 appos K14,Keratin
R759 T2962 T2956 punct ),promoter
R760 T2963 T2956 punct ", ",promoter
R761 T2964 T2965 dep which,is
R763 T2965 T2956 relcl is,promoter
R764 T2966 T2965 acomp active,is
R765 T2967 T2965 prep in,is
R767 T2968 T2969 amod basal,cells
R768 T2969 T2967 pobj cells,in
R769 T2970 T2969 prep of,cells
R771 T2971 T2970 pobj epidermis,of
R772 T2972 T2971 cc and,epidermis
R773 T2973 T2974 amod other,epithelia
R775 T2974 T2971 conj epithelia,epidermis
R776 T2975 T2974 amod stratified,epithelia
R777 T2976 T2943 punct .,mated
R779 T2978 T2979 nsubj We,report
R781 T2980 T2979 advmod here,report
R782 T2981 T2982 mark that,resulted
R783 T2982 T2979 ccomp resulted,report
R785 T2983 T2984 compound K14,promoter
R786 T2984 T2985 npadvmod promoter,driven
R787 T2985 T2987 amod driven,loss
R789 T2986 T2985 punct -,driven
R790 T2987 T2982 nsubj loss,resulted
R791 T2988 T2987 prep of,loss
R793 T2989 T2988 pobj Apc,of
R794 T2990 T2982 prep in,resulted
R796 T2991 T2992 amod aberrant,development
R797 T2992 T2990 pobj development,in
R798 T2993 T2992 prep of,development
R800 T2994 T2995 amod several,organs
R801 T2995 T2993 pobj organs,of
R802 T2996 T2997 dep that,require
R804 T2997 T2995 relcl require,organs
R805 T2998 T2999 amod inductive,interactions
R806 T2999 T2997 dobj interactions,require
R807 T3000 T3001 amod epithelial,mesenchymal
R808 T3001 T2999 amod mesenchymal,interactions
R809 T3002 T3001 punct –,mesenchymal
R810 T3003 T2995 punct ", ",organs
R812 T3004 T2995 prep including,organs
R813 T3005 T3006 compound hair,follicle
R814 T3006 T3004 pobj follicle,including
R816 T3007 T3006 punct ", ",follicle
R817 T3008 T3006 conj teeth,follicle
R818 T3009 T3008 punct ", ",teeth
R820 T3010 T3008 cc and,teeth
R821 T3011 T3008 conj thymus,teeth
R822 T3012 T2982 punct ", ",resulted
R824 T3013 T2982 cc and,resulted
R825 T3014 T2982 conj resulted,resulted
R828 T3015 T3014 prep in,resulted
R830 T3016 T3017 amod neonatal,death
R831 T3017 T3015 pobj death,in
R832 T3018 T3014 prep in,resulted
R834 T3019 T3018 pobj mice,in
R835 T3020 T2979 punct .,report
R837 T3022 T3023 nsubj We,found
R838 T3024 T3025 mark that,plays
R840 T3025 T3023 ccomp plays,found
R841 T3026 T3025 nsubj Apc,plays
R843 T3027 T3028 det a,role
R844 T3028 T3025 dobj role,plays
R848 T3029 T3028 amod crucial,role
R849 T3030 T3025 prep in,plays
R850 T3031 T3030 pobj determinations,in
R852 T3032 T3031 prep of,determinations
R853 T3033 T3034 compound cell,fates
R855 T3034 T3032 pobj fates,of
R856 T3035 T3025 prep during,plays
R858 T3036 T3037 det the,development
R859 T3037 T3035 pobj development,during
R860 T3038 T3037 amod embryonic,development
R861 T3039 T3025 punct ", ",plays
R862 T3040 T3041 advmod possibly,via
R863 T3041 T3025 prep via,plays
R865 T3042 T3043 amod temporal,regulation
R866 T3043 T3041 pobj regulation,via
R867 T3044 T3042 cc and,temporal
R868 T3045 T3046 npadvmod tissue,specific
R870 T3046 T3042 conj specific,temporal
R871 T3047 T3046 punct -,specific
R872 T3048 T3043 prep of,regulation
R874 T3049 T3050 compound β,catenin
R875 T3050 T3052 compound catenin,levels
R877 T3051 T3050 punct -,catenin
R878 T3052 T3048 pobj levels,of
R879 T3053 T3052 prep in,levels
R881 T3054 T3055 det the,skin
R882 T3055 T3053 pobj skin,in
R883 T3056 T3055 punct ", ",skin
R885 T3057 T3058 poss its,appendages
R886 T3058 T3055 appos appendages,skin
R887 T3059 T3053 punct ", ",in
R889 T3060 T3053 cc and,in
R890 T3061 T3053 conj in,in
R891 T3062 T3063 det the,thymus
R892 T2909 T2910 aux To,assess
R893 T3063 T3061 pobj thymus,in
R894 T3064 T3023 punct .,found
R895 T2910 T2911 advcl assess,generated
R896 T2912 T2913 det the,role
R897 T2913 T2910 dobj role,assess
R898 T2914 T2913 prep of,role
R899 T2915 T2914 pobj Apc,of
R900 T2916 T2913 prep in,role
R901 T2917 T2918 amod different,stages
R902 T2918 T2916 pobj stages,in
R903 T2919 T2918 prep of,stages
R904 T2920 T2919 pobj life,of
R905 T2921 T2910 advmod systematically,assess
R906 T2922 T2911 punct ", ",generated