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PMC:1564426 / 37363-38724 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T19066 4-6 VBZ denotes is
T19065 7-17 VBN denotes implicated
T19067 18-20 IN denotes in
T19068 21-24 DT denotes the
T19070 25-28 NN denotes Wnt
T19071 29-38 NN denotes signaling
T19069 39-46 NN denotes pathway
T19072 47-51 WDT denotes that
T19074 52-54 VBZ denotes is
T19073 55-63 VBN denotes involved
T19075 64-68 CC denotes both
T19076 69-71 IN denotes in
T19077 72-83 NN denotes development
T19078 84-87 CC denotes and
T19079 88-101 NN denotes tumorigenesis
T19080 101-102 . denotes .
T19081 102-320 sentence denotes Human germline mutations in APC cause FAP [4,5], which is characterized by hundreds of adenomatous colorectal polyps, with an almost inevitable progression to colorectal cancer in the third and fourth decades of life.
T19082 103-108 JJ denotes Human
T19084 109-117 NN denotes germline
T19083 118-127 NNS denotes mutations
T19086 128-130 IN denotes in
T19087 131-134 NN denotes APC
T19085 135-140 VBP denotes cause
T19088 141-144 NN denotes FAP
T19089 145-146 -LRB- denotes [
T19091 146-147 CD denotes 4
T19092 147-148 , denotes ,
T19090 148-149 CD denotes 5
T19093 149-150 -RRB- denotes ]
T19094 150-152 , denotes ,
T19095 152-157 WDT denotes which
T19097 158-160 VBZ denotes is
T19096 161-174 VBN denotes characterized
T19098 175-177 IN denotes by
T19099 178-186 NNS denotes hundreds
T19100 187-189 IN denotes of
T19101 190-201 JJ denotes adenomatous
T19103 202-212 JJ denotes colorectal
T19102 213-219 NNS denotes polyps
T19104 219-221 , denotes ,
T19105 221-225 IN denotes with
T19106 226-228 DT denotes an
T19108 229-235 RB denotes almost
T19109 236-246 JJ denotes inevitable
T19107 247-258 NN denotes progression
T19110 259-261 IN denotes to
T19111 262-272 JJ denotes colorectal
T19112 273-279 NN denotes cancer
T19113 280-282 IN denotes in
T19114 283-286 DT denotes the
T19116 287-292 JJ denotes third
T19117 293-296 CC denotes and
T19118 297-303 JJ denotes fourth
T19115 304-311 NNS denotes decades
T19119 312-314 IN denotes of
T19120 315-319 NN denotes life
T19121 319-320 . denotes .
T19122 320-412 sentence denotes The phenotypical features of FAP and its variant, Gardner's syndrome, can be very variable.
T19123 321-324 DT denotes The
T19125 325-337 JJ denotes phenotypical
T19124 338-346 NNS denotes features
T19127 347-349 IN denotes of
T19128 350-353 NN denotes FAP
T19129 354-357 CC denotes and
T19130 358-361 PRP$ denotes its
T19131 362-369 NN denotes variant
T19132 369-371 , denotes ,
T19133 371-378 NNP denotes Gardner
T19135 378-380 POS denotes 's
T19134 381-389 NN denotes syndrome
T19136 389-391 , denotes ,
T19137 391-394 MD denotes can
T19126 395-397 VB denotes be
T19138 398-402 RB denotes very
T19139 403-411 JJ denotes variable
T19140 411-412 . denotes .
T19141 412-699 sentence denotes As well as colorectal polyps, these individuals can develop extracolonic symptoms, among which are upper gastrointestinal tract polyps, congenital hypertrophy of the retinal pigment epithelium, desmoid tumors, disorders of the maxillary and skeletal bones, and dental abnormalities [6].
T19142 413-415 RB denotes As
T19144 416-420 RB denotes well
T19143 421-423 IN denotes as
T19146 424-434 JJ denotes colorectal
T19145 435-441 NNS denotes polyps
T19148 441-443 , denotes ,
T19149 443-448 DT denotes these
T19150 449-460 NNS denotes individuals
T19151 461-464 MD denotes can
T19147 465-472 VB denotes develop
T19152 473-485 JJ denotes extracolonic
T19153 486-494 NNS denotes symptoms
T19154 494-496 , denotes ,
T19155 496-501 IN denotes among
T19157 502-507 WDT denotes which
T19156 508-511 VBP denotes are
T19158 512-517 JJ denotes upper
T19160 518-534 JJ denotes gastrointestinal
T19159 535-540 NN denotes tract
T19161 541-547 NNS denotes polyps
T19162 547-549 , denotes ,
T19163 549-559 JJ denotes congenital
T19164 560-571 NN denotes hypertrophy
T19165 572-574 IN denotes of
T19166 575-578 DT denotes the
T19168 579-586 JJ denotes retinal
T19169 587-594 NN denotes pigment
T19167 595-605 NN denotes epithelium
T19170 605-607 , denotes ,
T19171 607-614 JJ denotes desmoid
T19172 615-621 NNS denotes tumors
T19173 621-623 , denotes ,
T19174 623-632 NNS denotes disorders
T19175 633-635 IN denotes of
T19176 636-639 DT denotes the
T19178 640-649 JJ denotes maxillary
T19179 650-653 CC denotes and
T19180 654-662 JJ denotes skeletal
T19177 663-668 NNS denotes bones
T19181 668-670 , denotes ,
T19182 670-673 CC denotes and
T19183 674-680 JJ denotes dental
T19184 681-694 NNS denotes abnormalities
T19185 695-696 -LRB- denotes [
T19186 696-697 CD denotes 6
T19187 697-698 -RRB- denotes ]
T19188 698-699 . denotes .
T19189 699-853 sentence denotes While the heterozygous knockout mice for Apc develop adenomatous polyps predominantly in small intestine, the homozygous embryos die before gastrulation.
T19190 700-705 IN denotes While
T19192 706-709 DT denotes the
T19194 710-722 JJ denotes heterozygous
T19195 723-731 NN denotes knockout
T19193 732-736 NNS denotes mice
T19196 737-740 IN denotes for
T19197 741-744 NN denotes Apc
T19191 745-752 VBP denotes develop
T19199 753-764 JJ denotes adenomatous
T19200 765-771 NNS denotes polyps
T19201 772-785 RB denotes predominantly
T19202 786-788 IN denotes in
T19203 789-794 JJ denotes small
T19204 795-804 NN denotes intestine
T19205 804-806 , denotes ,
T19206 806-809 DT denotes the
T19208 810-820 JJ denotes homozygous
T19207 821-828 NNS denotes embryos
T19198 829-832 VBP denotes die
T19209 833-839 IN denotes before
T19210 840-852 NN denotes gastrulation
T19211 852-853 . denotes .
T19212 853-1179 sentence denotes To gain more insights into the effects of Apc loss in tissues other than gastrointestinal tract during life of animals and to circumvent the embryonic lethality associated with Apc nullizygosity, we created a mouse strain carrying a conditional allele of Apc (ApcCKO) in which exon 14 of the Apc is flanked by loxP sequences.
T19213 854-856 TO denotes To
T19214 857-861 VB denotes gain
T19216 862-866 JJR denotes more
T19217 867-875 NNS denotes insights
T19218 876-880 IN denotes into
T19219 881-884 DT denotes the
T19220 885-892 NNS denotes effects
T19221 893-895 IN denotes of
T19222 896-899 NN denotes Apc
T19223 900-904 NN denotes loss
T19224 905-907 IN denotes in
T19225 908-915 NNS denotes tissues
T19226 916-921 JJ denotes other
T19227 922-926 IN denotes than
T19228 927-943 JJ denotes gastrointestinal
T19229 944-949 NN denotes tract
T19230 950-956 IN denotes during
T19231 957-961 NN denotes life
T19232 962-964 IN denotes of
T19233 965-972 NNS denotes animals
T19234 973-976 CC denotes and
T19235 977-979 TO denotes to
T19236 980-990 VB denotes circumvent
T19237 991-994 DT denotes the
T19239 995-1004 JJ denotes embryonic
T19238 1005-1014 NN denotes lethality
T19240 1015-1025 VBN denotes associated
T19241 1026-1030 IN denotes with
T19242 1031-1034 NN denotes Apc
T19243 1035-1048 NN denotes nullizygosity
T19244 1048-1050 , denotes ,
T19245 1050-1052 PRP denotes we
T19215 1053-1060 VBD denotes created
T19246 1061-1062 DT denotes a
T19248 1063-1068 NN denotes mouse
T19247 1069-1075 NN denotes strain
T19249 1076-1084 VBG denotes carrying
T19250 1085-1086 DT denotes a
T19252 1087-1098 JJ denotes conditional
T19251 1099-1105 NN denotes allele
T19253 1106-1108 IN denotes of
T19254 1109-1112 NN denotes Apc
T19255 1113-1114 -LRB- denotes (
T19256 1114-1120 NN denotes ApcCKO
T19257 1120-1121 -RRB- denotes )
T19258 1122-1124 IN denotes in
T19260 1125-1130 WDT denotes which
T19261 1131-1135 NN denotes exon
T19262 1136-1138 CD denotes 14
T19263 1139-1141 IN denotes of
T19264 1142-1145 DT denotes the
T19265 1146-1149 NN denotes Apc
T19266 1150-1152 VBZ denotes is
T19259 1153-1160 VBN denotes flanked
T19267 1161-1163 IN denotes by
T19268 1164-1168 NN denotes loxP
T19269 1169-1178 NNS denotes sequences
T19270 1178-1179 . denotes .
T19271 1179-1360 sentence denotes The homozygous mice for the conditional allele are viable and indistinguishable to the normal mice, allowing us to study the roles of Apc in a tissue- and temporal-specific manner.
T19272 1180-1183 DT denotes The
T19274 1184-1194 JJ denotes homozygous
T19273 1195-1199 NNS denotes mice
T19276 1200-1203 IN denotes for
T19277 1204-1207 DT denotes the
T19279 1208-1219 JJ denotes conditional
T19278 1220-1226 NN denotes allele
T19275 1227-1230 VBP denotes are
T19280 1231-1237 JJ denotes viable
T19281 1238-1241 CC denotes and
T19282 1242-1259 JJ denotes indistinguishable
T19283 1260-1262 IN denotes to
T19284 1263-1266 DT denotes the
T19286 1267-1273 JJ denotes normal
T19285 1274-1278 NNS denotes mice
T19287 1278-1280 , denotes ,
T19288 1280-1288 VBG denotes allowing
T19289 1289-1291 PRP denotes us
T19291 1292-1294 TO denotes to
T19290 1295-1300 VB denotes study
T19292 1301-1304 DT denotes the
T19293 1305-1310 NNS denotes roles
T19294 1311-1313 IN denotes of
T19295 1314-1317 NN denotes Apc
T19296 1318-1320 IN denotes in
T19297 1321-1322 DT denotes a
T19299 1323-1329 NN denotes tissue
T19301 1329-1330 HYPH denotes -
T19302 1331-1334 CC denotes and
T19303 1335-1343 JJ denotes temporal
T19304 1343-1344 HYPH denotes -
T19300 1344-1352 JJ denotes specific
T19298 1353-1359 NN denotes manner
T19305 1359-1360 . denotes .
R5655 T19066 T19065 auxpass is,implicated
R5656 T19067 T19065 prep in,implicated
R5657 T19068 T19069 det the,pathway
R5658 T19069 T19067 pobj pathway,in
R5659 T19070 T19069 compound Wnt,pathway
R5660 T19071 T19069 compound signaling,pathway
R5661 T19072 T19073 dep that,involved
R5662 T19073 T19069 relcl involved,pathway
R5663 T19074 T19073 auxpass is,involved
R5664 T19075 T19076 preconj both,in
R5665 T19076 T19073 prep in,involved
R5666 T19077 T19076 pobj development,in
R5667 T19078 T19077 cc and,development
R5668 T19079 T19077 conj tumorigenesis,development
R5669 T19080 T19065 punct .,implicated
R5670 T19082 T19083 amod Human,mutations
R5671 T19083 T19085 nsubj mutations,cause
R5672 T19084 T19083 compound germline,mutations
R5673 T19086 T19083 prep in,mutations
R5674 T19087 T19086 pobj APC,in
R5675 T19088 T19085 dobj FAP,cause
R5676 T19089 T19090 punct [,5
R5677 T19090 T19088 parataxis 5,FAP
R5678 T19091 T19090 nummod 4,5
R5679 T19092 T19090 punct ",",5
R5680 T19093 T19090 punct ],5
R5681 T19094 T19088 punct ", ",FAP
R5682 T19095 T19096 dep which,characterized
R5683 T19096 T19088 relcl characterized,FAP
R5684 T19097 T19096 auxpass is,characterized
R5685 T19098 T19096 agent by,characterized
R5686 T19099 T19098 pobj hundreds,by
R5687 T19100 T19099 prep of,hundreds
R5688 T19101 T19102 amod adenomatous,polyps
R5689 T19102 T19100 pobj polyps,of
R5690 T19103 T19102 amod colorectal,polyps
R5691 T19104 T19088 punct ", ",FAP
R5692 T19105 T19088 prep with,FAP
R5693 T19106 T19107 det an,progression
R5694 T19107 T19105 pobj progression,with
R5695 T19108 T19109 advmod almost,inevitable
R5696 T19109 T19107 amod inevitable,progression
R5697 T19110 T19107 prep to,progression
R5698 T19111 T19112 amod colorectal,cancer
R5699 T19112 T19110 pobj cancer,to
R5700 T19113 T19107 prep in,progression
R5701 T19114 T19115 det the,decades
R5702 T19115 T19113 pobj decades,in
R5703 T19116 T19115 amod third,decades
R5704 T19117 T19116 cc and,third
R5705 T19118 T19116 conj fourth,third
R5706 T19119 T19115 prep of,decades
R5707 T19120 T19119 pobj life,of
R5708 T19121 T19085 punct .,cause
R5709 T19123 T19124 det The,features
R5710 T19124 T19126 nsubj features,be
R5711 T19125 T19124 amod phenotypical,features
R5712 T19127 T19124 prep of,features
R5713 T19128 T19127 pobj FAP,of
R5714 T19129 T19128 cc and,FAP
R5715 T19130 T19131 poss its,variant
R5716 T19131 T19128 conj variant,FAP
R5717 T19132 T19131 punct ", ",variant
R5718 T19133 T19134 poss Gardner,syndrome
R5719 T19134 T19131 appos syndrome,variant
R5720 T19135 T19133 case 's,Gardner
R5721 T19136 T19126 punct ", ",be
R5722 T19137 T19126 aux can,be
R5723 T19138 T19139 advmod very,variable
R5724 T19139 T19126 acomp variable,be
R5725 T19140 T19126 punct .,be
R5726 T19142 T19143 advmod As,as
R5727 T19143 T19145 cc as,polyps
R5728 T19144 T19143 advmod well,as
R5729 T19145 T19147 dep polyps,develop
R5730 T19146 T19145 amod colorectal,polyps
R5731 T19148 T19147 punct ", ",develop
R5732 T19149 T19150 det these,individuals
R5733 T19150 T19147 nsubj individuals,develop
R5734 T19151 T19147 aux can,develop
R5735 T19152 T19153 amod extracolonic,symptoms
R5736 T19153 T19147 dobj symptoms,develop
R5737 T19154 T19153 punct ", ",symptoms
R5738 T19155 T19156 prep among,are
R5739 T19156 T19153 relcl are,symptoms
R5740 T19157 T19155 pobj which,among
R5741 T19158 T19159 amod upper,tract
R5742 T19159 T19161 compound tract,polyps
R5743 T19160 T19159 amod gastrointestinal,tract
R5744 T19161 T19156 nsubj polyps,are
R5745 T19162 T19161 punct ", ",polyps
R5746 T19163 T19164 amod congenital,hypertrophy
R5747 T19164 T19161 conj hypertrophy,polyps
R5748 T19165 T19164 prep of,hypertrophy
R5749 T19166 T19167 det the,epithelium
R5750 T19167 T19165 pobj epithelium,of
R5751 T19168 T19167 amod retinal,epithelium
R5752 T19169 T19167 compound pigment,epithelium
R5753 T19170 T19164 punct ", ",hypertrophy
R5754 T19171 T19172 amod desmoid,tumors
R5755 T19172 T19164 conj tumors,hypertrophy
R5756 T19173 T19172 punct ", ",tumors
R5757 T19174 T19172 conj disorders,tumors
R5758 T19175 T19174 prep of,disorders
R5759 T19176 T19177 det the,bones
R5760 T19177 T19175 pobj bones,of
R5761 T19178 T19177 amod maxillary,bones
R5762 T19179 T19178 cc and,maxillary
R5763 T19180 T19178 conj skeletal,maxillary
R5764 T19181 T19174 punct ", ",disorders
R5765 T19182 T19174 cc and,disorders
R5766 T19183 T19184 amod dental,abnormalities
R5767 T19184 T19174 conj abnormalities,disorders
R5768 T19185 T19186 punct [,6
R5769 T19186 T19147 parataxis 6,develop
R5770 T19187 T19186 punct ],6
R5771 T19188 T19147 punct .,develop
R5772 T19190 T19191 mark While,develop
R5773 T19191 T19198 advcl develop,die
R5774 T19192 T19193 det the,mice
R5775 T19193 T19191 nsubj mice,develop
R5776 T19194 T19195 amod heterozygous,knockout
R5777 T19195 T19193 compound knockout,mice
R5778 T19196 T19193 prep for,mice
R5779 T19197 T19196 pobj Apc,for
R5780 T19199 T19200 amod adenomatous,polyps
R5781 T19200 T19191 dobj polyps,develop
R5782 T19201 T19202 advmod predominantly,in
R5783 T19202 T19191 prep in,develop
R5784 T19203 T19204 amod small,intestine
R5785 T19204 T19202 pobj intestine,in
R5786 T19205 T19198 punct ", ",die
R5787 T19206 T19207 det the,embryos
R5788 T19207 T19198 nsubj embryos,die
R5789 T19208 T19207 amod homozygous,embryos
R5790 T19209 T19198 prep before,die
R5791 T19210 T19209 pobj gastrulation,before
R5792 T19211 T19198 punct .,die
R5793 T19213 T19214 aux To,gain
R5794 T19214 T19215 advcl gain,created
R5795 T19216 T19217 amod more,insights
R5796 T19217 T19214 dobj insights,gain
R5797 T19218 T19217 prep into,insights
R5798 T19219 T19220 det the,effects
R5799 T19220 T19218 pobj effects,into
R5800 T19221 T19220 prep of,effects
R5801 T19222 T19223 compound Apc,loss
R5802 T19223 T19221 pobj loss,of
R5803 T19224 T19220 prep in,effects
R5804 T19225 T19224 pobj tissues,in
R5805 T19226 T19225 amod other,tissues
R5806 T19227 T19226 prep than,other
R5807 T19228 T19229 amod gastrointestinal,tract
R5808 T19229 T19227 pobj tract,than
R5809 T19230 T19220 prep during,effects
R5810 T19231 T19230 pobj life,during
R5811 T19232 T19231 prep of,life
R5812 T19233 T19232 pobj animals,of
R5813 T19234 T19214 cc and,gain
R5814 T19235 T19236 aux to,circumvent
R5815 T19236 T19214 conj circumvent,gain
R5816 T19237 T19238 det the,lethality
R5817 T19238 T19236 dobj lethality,circumvent
R5818 T19239 T19238 amod embryonic,lethality
R5819 T19240 T19238 acl associated,lethality
R5820 T19241 T19240 prep with,associated
R5821 T19242 T19243 compound Apc,nullizygosity
R5822 T19243 T19241 pobj nullizygosity,with
R5823 T19244 T19215 punct ", ",created
R5824 T19245 T19215 nsubj we,created
R5825 T19246 T19247 det a,strain
R5826 T19247 T19215 dobj strain,created
R5827 T19248 T19247 compound mouse,strain
R5828 T19249 T19247 acl carrying,strain
R5829 T19250 T19251 det a,allele
R5830 T19251 T19249 dobj allele,carrying
R5831 T19252 T19251 amod conditional,allele
R5832 T19253 T19251 prep of,allele
R5833 T19254 T19253 pobj Apc,of
R5834 T19255 T19256 punct (,ApcCKO
R5835 T19256 T19251 parataxis ApcCKO,allele
R5836 T19257 T19256 punct ),ApcCKO
R5837 T19258 T19259 prep in,flanked
R5838 T19259 T19251 relcl flanked,allele
R5839 T19260 T19258 pobj which,in
R5840 T19261 T19259 nsubjpass exon,flanked
R5841 T19262 T19261 nummod 14,exon
R5842 T19263 T19261 prep of,exon
R5843 T19264 T19265 det the,Apc
R5844 T19265 T19263 pobj Apc,of
R5845 T19266 T19259 auxpass is,flanked
R5846 T19267 T19259 agent by,flanked
R5847 T19268 T19269 compound loxP,sequences
R5848 T19269 T19267 pobj sequences,by
R5849 T19270 T19215 punct .,created
R5850 T19272 T19273 det The,mice
R5851 T19273 T19275 nsubj mice,are
R5852 T19274 T19273 amod homozygous,mice
R5853 T19276 T19273 prep for,mice
R5854 T19277 T19278 det the,allele
R5855 T19278 T19276 pobj allele,for
R5856 T19279 T19278 amod conditional,allele
R5857 T19280 T19275 acomp viable,are
R5858 T19281 T19280 cc and,viable
R5859 T19282 T19280 conj indistinguishable,viable
R5860 T19283 T19282 prep to,indistinguishable
R5861 T19284 T19285 det the,mice
R5862 T19285 T19283 pobj mice,to
R5863 T19286 T19285 amod normal,mice
R5864 T19287 T19275 punct ", ",are
R5865 T19288 T19275 advcl allowing,are
R5866 T19289 T19290 nsubj us,study
R5867 T19290 T19288 ccomp study,allowing
R5868 T19291 T19290 aux to,study
R5869 T19292 T19293 det the,roles
R5870 T19293 T19290 dobj roles,study
R5871 T19294 T19293 prep of,roles
R5872 T19295 T19294 pobj Apc,of
R5873 T19296 T19290 prep in,study
R5874 T19297 T19298 det a,manner
R5875 T19298 T19296 pobj manner,in
R5876 T19299 T19300 npadvmod tissue,specific
R5877 T19300 T19298 amod specific,manner
R5878 T19301 T19299 punct -,tissue
R5879 T19302 T19299 cc and,tissue
R5880 T19303 T19299 conj temporal,tissue
R5881 T19304 T19300 punct -,specific
R5882 T19305 T19275 punct .,are